                         SEQUENCE LISTING

<110>  Case Western Reserve University
 
<120>  COMPOSITIONS AND METHODS FOR TREATING HEART DISEASE AND/OR INJURY

<130>  CWR-023134WO ORD

<150>  61/948,396
<151>  2014-03-05

<160>  58    

<170>  PatentIn version 3.5

<210>  1
<211>  22
<212>  PRT
<213>  Xenopus

<400>  1

Asp Leu Ala Glu His Thr Glu His Leu Lys Ala Asn Asp Asn Leu Lys 
1               5                   10                  15      


Ser Gln Glu Tyr Glu Ser 
            20          


<210>  2
<211>  21
<212>  PRT
<213>  Green Anole

<400>  2

Asp His Thr Glu His Leu Lys Ala Asn Asp Asn Leu Lys Leu Ser Gln 
1               5                   10                  15      


Glu Tyr Glu Ser Ile 
            20      


<210>  3
<211>  24
<212>  PRT
<213>  Zebrafish

<400>  3

Glu Leu Ala Glu His Thr Glu Leu Leu Lys Ala Asn Asp Asn Leu Lys 
1               5                   10                  15      


Leu Ser Gln Glu Tyr Glu Ser Ile 
            20                  


<210>  4
<211>  24
<212>  PRT
<213>  Talapia

<400>  4

Glu Leu Ala Glu His Thr Glu Leu Leu Lys Ala Asn Asp Asn Leu Lys 
1               5                   10                  15      


Leu Ser Gln Glu Tyr Glu Ser Ile 
            20                  


<210>  5
<211>  24
<212>  PRT
<213>  Chicken

<400>  5

Glu Leu Ala Glu His Thr Glu His Leu Lys Ala Asn Asp Asn Leu Lys 
1               5                   10                  15      


Leu Ser Gln Glu Tyr Glu Ser Ile 
            20                  


<210>  6
<211>  24
<212>  PRT
<213>  Finch

<400>  6

Glu Leu Ala Glu His Thr Glu His Leu Lys Ala Asn Asp Asn Leu Lys 
1               5                   10                  15      


Leu Ser Gln Glu Tyr Glu Ser Ile 
            20                  


<210>  7
<211>  24
<212>  PRT
<213>  Platypus

<400>  7

Glu Leu Ala Glu His Thr Asp His Leu Lys Ala Asn Asp Asn Leu Lys 
1               5                   10                  15      


Leu Ser Gln Glu Tyr Glu Ser Ile 
            20                  


<210>  8
<211>  24
<212>  PRT
<213>  Tazmanian Devil

<400>  8

Glu Met Ala Glu His Thr Glu His Leu Lys Ala Asn Asp Asn Leu Lys 
1               5                   10                  15      


Leu Ser Gln Glu Tyr Glu Ser Ile 
            20                  


<210>  9
<211>  24
<212>  PRT
<213>  Ferret

<400>  9

Asp Met Ala Glu His Thr Glu Arg Leu Lys Ala Asn Asp Ser Leu Lys 
1               5                   10                  15      


Leu Ser Gln Glu Tyr Glu Ser Ile 
            20                  


<210>  10
<211>  24
<212>  PRT
<213>  Bush-Baby

<400>  10

Asp Met Ala Glu His Thr Glu Arg Leu Lys Ala Asn Asp Ser Leu Lys 
1               5                   10                  15      


Leu Ser Gln Glu Tyr Glu Ser Ile 
            20                  


<210>  11
<211>  24
<212>  PRT
<213>  Marmoset

<400>  11

Asp Met Ala Glu His Thr Glu Arg Leu Lys Ala Asn Asp Ser Leu Lys 
1               5                   10                  15      


Leu Ser Gln Glu Tyr Glu Ser Ile 
            20                  


<210>  12
<211>  24
<212>  PRT
<213>  Rat

<400>  12

Asp Met Ala Glu His Met Glu Arg Leu Lys Ala Asn Asp Ser Leu Lys 
1               5                   10                  15      


Leu Ser Gln Glu Tyr Glu Ser Ile 
            20                  


<210>  13
<211>  24
<212>  PRT
<213>  Mouse

<400>  13

Asp Met Ala Glu His Met Glu Arg Leu Lys Ala Asn Asp Ser Leu Lys 
1               5                   10                  15      


Leu Ser Gln Glu Tyr Glu Ser Ile 
            20                  


<210>  14
<211>  24
<212>  PRT
<213>  Dog

<400>  14

Asp Met Ala Glu His Thr Glu Arg Leu Lys Ala Asn Asp Ser Leu Lys 
1               5                   10                  15      


Leu Ser Gln Glu Tyr Glu Ser Ile 
            20                  


<210>  15
<211>  24
<212>  PRT
<213>  Pig

<400>  15

Asp Met Ala Glu His Thr Glu Arg Leu Lys Ala Asn Asp Ser Leu Lys 
1               5                   10                  15      


Leu Ser Gln Glu Tyr Glu Ser Ile 
            20                  


<210>  16
<211>  24
<212>  PRT
<213>  Cow

<400>  16

Asp Met Ala Glu His Thr Glu Arg Leu Lys Ala Asn Asp Ser Leu Lys 
1               5                   10                  15      


Leu Ser Gln Glu Tyr Glu Ser Ile 
            20                  


<210>  17
<211>  24
<212>  PRT
<213>  Sheep

<400>  17

Asp Met Ala Glu His Thr Glu Arg Leu Lys Ala Asn Asp Ser Leu Lys 
1               5                   10                  15      


Leu Ser Gln Glu Tyr Glu Ser Ile 
            20                  


<210>  18
<211>  24
<212>  PRT
<213>  Killer Whale

<400>  18

Asp Met Ala Glu His Thr Glu Arg Leu Lys Ala Asn Asp Ser Leu Lys 
1               5                   10                  15      


Leu Ser Gln Glu Tyr Glu Ser Ile 
            20                  


<210>  19
<211>  24
<212>  PRT
<213>  Squirrel Monkey

<400>  19

Asp Met Ala Glu His Thr Glu Arg Leu Lys Ala Asn Asp Ser Leu Lys 
1               5                   10                  15      


Leu Ser Gln Glu Tyr Glu Ser Ile 
            20                  


<210>  20
<211>  24
<212>  PRT
<213>  Baboon

<400>  20

Asp Met Ala Glu His Thr Glu Arg Leu Lys Ala Asn Asp Ser Leu Lys 
1               5                   10                  15      


Leu Ser Gln Glu Tyr Glu Ser Ile 
            20                  


<210>  21
<211>  24
<212>  PRT
<213>  Gorilla

<400>  21

Asp Met Ala Glu His Thr Glu Arg Leu Lys Ala Asn Asp Ser Leu Lys 
1               5                   10                  15      


Leu Ser Gln Glu Tyr Glu Ser Ile 
            20                  


<210>  22
<211>  24
<212>  PRT
<213>  Gibbon

<400>  22

Asp Met Ala Glu His Thr Glu Arg Leu Lys Ala Asn Asp Ser Leu Lys 
1               5                   10                  15      


Leu Ser Gln Glu Tyr Glu Ser Ile 
            20                  


<210>  23
<211>  24
<212>  PRT
<213>  Macque

<400>  23

Asp Met Ala Glu His Thr Glu Arg Leu Lys Ala Asn Asp Ser Leu Lys 
1               5                   10                  15      


Leu Ser Gln Glu Tyr Glu Ser Ile 
            20                  


<210>  24
<211>  24
<212>  PRT
<213>  Chimpanzee

<400>  24

Asp Met Ala Glu His Thr Glu Arg Leu Lys Ala Asn Asp Ser Leu Lys 
1               5                   10                  15      


Leu Ser Gln Glu Tyr Glu Ser Ile 
            20                  


<210>  25
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  25

Asp Met Ala Glu His Thr Glu Arg Leu Lys Ala Asn Asp Ser Leu Lys 
1               5                   10                  15      


Leu Ser Gln Glu Tyr Glu Ser Ile 
            20                  


<210>  26
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  26

Asp Leu Ala Asp Asn Ile Glu Arg Leu Lys Ala Asn Asp Gly Leu Lys 
1               5                   10                  15      


Phe Ser Gln Glu Tyr Glu Ser Ile 
            20                  


<210>  27
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  27

Glu Leu Ala Asp His Ile Glu Arg Leu Lys Ala Asn Asp Asn Leu Lys 
1               5                   10                  15      


Phe Ser Gln Glu Tyr Glu Ser Ile 
            20                  


<210>  28
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  28

Lys Leu Glu Glu Glu Ile Asn Arg Arg Met Ala Asp Asp Asn Lys Ile 
1               5                   10                  15      


Phe Arg Glu Glu Phe Asn Ala Leu 
            20                  


<210>  29
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  29

Asp Met Ala Glu His Thr Glu Arg Leu Lys 
1               5                   10  


<210>  30
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  30

Ala Asn Asp Ser 
1               


<210>  31
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  31

Leu Lys Leu Ser Gln Glu Tyr Glu Ser Ile 
1               5                   10  


<210>  32
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  X is T or M


<220>
<221>  Xaa
<222>  (3)..(3)
<223>  Xaa is T or M

<400>  32

Glu His Xaa Glu Arg Leu Lys Ala Asn Asp Ser Leu Lys Leu 
1               5                   10                  


<210>  33
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  33

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Cys Asp Leu Ala Glu His 
1               5                   10                  15      


Thr Glu His Leu Lys Ala Asn Asp Asn Leu Lys Ser Gln Glu Tyr Glu 
            20                  25                  30          


Ser 
    


<210>  34
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  34

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Cys Asp His Thr Glu His 
1               5                   10                  15      


Leu Lys Ala Asn Asp Asn Leu Lys Leu Ser Gln Glu Tyr Glu Ser Ile 
            20                  25                  30          


<210>  35
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  35

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Cys Glu Leu Ala Glu His 
1               5                   10                  15      


Thr Glu Leu Leu Lys Ala Asn Asp Asn Leu Lys Leu Ser Gln Glu Tyr 
            20                  25                  30          


Glu Ser Ile 
        35  


<210>  36
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  36

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Cys Glu Leu Ala Glu His 
1               5                   10                  15      


Thr Glu Leu Leu Lys Ala Asn Asp Asn Leu Lys Leu Ser Gln Glu Tyr 
            20                  25                  30          


Glu Ser Ile 
        35  


<210>  37
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  37

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Cys Glu Leu Ala Glu His 
1               5                   10                  15      


Thr Glu His Leu Lys Ala Asn Asp Asn Leu Lys Leu Ser Gln Glu Tyr 
            20                  25                  30          


Glu Ser Ile 
        35  


<210>  38
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  38

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Cys Glu Leu Ala Glu His 
1               5                   10                  15      


Thr Glu His Leu Lys Ala Asn Asp Asn Leu Lys Leu Ser Gln Glu Tyr 
            20                  25                  30          


Glu Ser Ile 
        35  


<210>  39
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  39

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Cys Glu Leu Ala Glu His 
1               5                   10                  15      


Thr Asp His Leu Lys Ala Asn Asp Asn Leu Lys Leu Ser Gln Glu Tyr 
            20                  25                  30          


Glu Ser Ile 
        35  


<210>  40
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  40

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Cys Glu Met Ala Glu His 
1               5                   10                  15      


Thr Glu His Leu Lys Ala Asn Asp Asn Leu Lys Leu Ser Gln Glu Tyr 
            20                  25                  30          


Glu Ser Ile 
        35  


<210>  41
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  41

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Cys Asp Met Ala Glu His 
1               5                   10                  15      


Thr Glu Arg Leu Lys Ala Asn Asp Ser Leu Lys Leu Ser Gln Glu Tyr 
            20                  25                  30          


Glu Ser Ile 
        35  


<210>  42
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  42

Asp Met Ala Glu His Thr Glu Arg Leu Lys Ala Asn Asp Ser Leu Lys 
1               5                   10                  15      


Leu Ser Gln Glu Tyr Glu Ser Ile Gly Arg Lys Lys Arg Arg Gln Arg 
            20                  25                  30          


Arg Arg Cys 
        35  


<210>  43
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  43

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Cys Asp Met Ala Glu His 
1               5                   10                  15      


Thr Glu Arg Leu Lys Ala Asn Asp Ser Leu Lys Leu Ser Gln Glu Tyr 
            20                  25                  30          


Glu Ser Ile 
        35  


<210>  44
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  44

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Cys Asp Met Ala Glu His 
1               5                   10                  15      


Met Glu Arg Leu Lys Ala Asn Asp Ser Leu Lys Leu Ser Gln Glu Tyr 
            20                  25                  30          


Glu Ser Ile 
        35  


<210>  45
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  45

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Cys Asp Met Ala Glu His 
1               5                   10                  15      


Met Glu Arg Leu Lys Ala Asn Asp Ser Leu Lys Leu Ser Gln Glu Tyr 
            20                  25                  30          


Glu Ser Ile 
        35  


<210>  46
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  46

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Cys Asp Met Ala Glu His 
1               5                   10                  15      


Thr Glu Arg Leu Lys Ala Asn Asp Ser Leu Lys Leu Ser Gln Glu Tyr 
            20                  25                  30          


Glu Ser Ile 
        35  


<210>  47
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  47

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Cys Asp Met Ala Glu His 
1               5                   10                  15      


Thr Glu Arg Leu Lys Ala Asn Asp Ser Leu Lys Leu Ser Gln Glu Tyr 
            20                  25                  30          


Glu Ser Ile 
        35  


<210>  48
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  48

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Cys Asp Met Ala Glu His 
1               5                   10                  15      


Thr Glu Arg Leu Lys Ala Asn Asp Ser Leu Lys Leu Ser Gln Glu Tyr 
            20                  25                  30          


Glu Ser Ile 
        35  


<210>  49
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  49

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Cys Asp Met Ala Glu His 
1               5                   10                  15      


Thr Glu Arg Leu Lys Ala Asn Asp Ser Leu Lys Leu Ser Gln Glu Tyr 
            20                  25                  30          


Glu Ser Ile 
        35  


<210>  50
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  50

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Cys Asp Met Ala Glu His 
1               5                   10                  15      


Thr Glu Arg Leu Lys Ala Asn Asp Ser Leu Lys Leu Ser Gln Glu Tyr 
            20                  25                  30          


Glu Ser Ile 
        35  


<210>  51
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  51

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Cys Asp Met Ala Glu His 
1               5                   10                  15      


Thr Glu Arg Leu Lys Ala Asn Asp Ser Leu Lys Leu Ser Gln Glu Tyr 
            20                  25                  30          


Glu Ser Ile 
        35  


<210>  52
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  52

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Cys Asp Met Ala Glu His 
1               5                   10                  15      


Thr Glu Arg Leu Lys Ala Asn Asp Ser Leu Lys Leu Ser Gln Glu Tyr 
            20                  25                  30          


Glu Ser Ile 
        35  


<210>  53
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  53

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Cys Asp Met Ala Glu His 
1               5                   10                  15      


Thr Glu Arg Leu Lys Ala Asn Asp Ser Leu Lys Leu Ser Gln Glu Tyr 
            20                  25                  30          


Glu Ser Ile 
        35  


<210>  54
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  54

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Cys Asp Met Ala Glu His 
1               5                   10                  15      


Thr Glu Arg Leu Lys Ala Asn Asp Ser Leu Lys Leu Ser Gln Glu Tyr 
            20                  25                  30          


Glu Ser Ile 
        35  


<210>  55
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  55

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Cys Asp Met Ala Glu His 
1               5                   10                  15      


Thr Glu Arg Leu Lys Ala Asn Asp Ser Leu Lys Leu Ser Gln Glu Tyr 
            20                  25                  30          


Glu Ser Ile 
        35  


<210>  56
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  56

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Cys Asp Met Ala Glu His 
1               5                   10                  15      


Thr Glu Arg Leu Lys Ala Asn Asp Ser Leu Lys Leu Ser Gln Glu Tyr 
            20                  25                  30          


Glu Ser Ile 
        35  


<210>  57
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  57

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Cys Glu Leu Ala Asp His 
1               5                   10                  15      


Ile Glu Arg Leu Lys Ala Asn Asp Asn Leu Lys Phe Ser Gln Glu Tyr 
            20                  25                  30          


Glu Ser Ile 
        35  


<210>  58
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  Xaa
<222>  (3)..(3)
<223>  Xaa is T or M

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be any naturally occurring amino acid

<400>  58

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Cys Glu His Xaa Glu Arg 
1               5                   10                  15      


Leu Lys Ala Asn Asp Ser Leu Lys Leu 
            20                  25  


