                         SEQUENCE LISTING

<110>  Morphogenesis, Inc.
 
<120>  DNA Vector Vaccines

<130>  MOR.203XC1PCT

<150>  US 61/948,980
<151>  2014-03-06

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  1656
<212>  DNA
<213>  Streptococcus pyogenes


<220>
<221>  CDS
<222>  (1)..(1656)

<400>  1
atg gct aaa aat acc acg aat aga cac tat tcg ctt aga aaa tta aaa     48
Met Ala Lys Asn Thr Thr Asn Arg His Tyr Ser Leu Arg Lys Leu Lys         
1               5                   10                  15              

aca gga acg gct tca gta gca gta gct ttg act gtt tta ggg aca gga     96
Thr Gly Thr Ala Ser Val Ala Val Ala Leu Thr Val Leu Gly Thr Gly         
            20                  25                  30                  

ctg gta gca ggg cag aca gta aaa gca agc caa aca gaa cca tct cag    144
Leu Val Ala Gly Gln Thr Val Lys Ala Ser Gln Thr Glu Pro Ser Gln         
        35                  40                  45                      

acc aat aac aga tta tat caa gaa aga caa cgt tta cag gat tta aaa    192
Thr Asn Asn Arg Leu Tyr Gln Glu Arg Gln Arg Leu Gln Asp Leu Lys         
    50                  55                  60                            

agt aag ttt caa gac ctg aaa aat cgt tca gag gga tac att cag caa    240
Ser Lys Phe Gln Asp Leu Lys Asn Arg Ser Glu Gly Tyr Ile Gln Gln           
65                  70                  75                  80            

tac tac gac gaa gaa aag aac agt gga agt aac tct aac tgg tac gca    288
Tyr Tyr Asp Glu Glu Lys Asn Ser Gly Ser Asn Ser Asn Trp Tyr Ala           
                85                  90                  95                

acc tac tta aaa gaa tta aat gac gaa ttt gaa caa gct tat aat gaa    336
Thr Tyr Leu Lys Glu Leu Asn Asp Glu Phe Glu Gln Ala Tyr Asn Glu           
            100                 105                 110                   

ctt agt ggt gat ggt gta aaa aaa tta gct gca agt ttg atg gaa gaa    384
Leu Ser Gly Asp Gly Val Lys Lys Leu Ala Ala Ser Leu Met Glu Glu           
        115                 120                 125                       

aga gtc gct tta aga gac gaa atc gat cag att aag aaa ata tca gaa    432
Arg Val Ala Leu Arg Asp Glu Ile Asp Gln Ile Lys Lys Ile Ser Glu           
    130                 135                 140                           

gaa tta aaa aat aag ctg aga gca aaa gaa gaa gaa tta aaa aat aaa    480
Glu Leu Lys Asn Lys Leu Arg Ala Lys Glu Glu Glu Leu Lys Asn Lys           
145                 150                 155                 160           

aaa gag gaa cgt gag ctt gag cat gct gcc tat gca gca gat gca aag    528
Lys Glu Glu Arg Glu Leu Glu His Ala Ala Tyr Ala Ala Asp Ala Lys           
                165                 170                 175               

aaa cat gaa gaa tat gtc aaa tcc atg tct ctc gta cta atg gat aaa    576
Lys His Glu Glu Tyr Val Lys Ser Met Ser Leu Val Leu Met Asp Lys           
            180                 185                 190                   

gaa gag gag cgt cat aaa cta gag caa tca tta gac acg gct aaa gct    624
Glu Glu Glu Arg His Lys Leu Glu Gln Ser Leu Asp Thr Ala Lys Ala           
        195                 200                 205                       

gag ctt gtt aaa aaa gag caa gag tta cag tta gtc aaa ggc aat cta    672
Glu Leu Val Lys Lys Glu Gln Glu Leu Gln Leu Val Lys Gly Asn Leu           
    210                 215                 220                           

gat caa aaa gaa aaa gaa cta gaa aat gaa gag cta gcg aaa gaa agt    720
Asp Gln Lys Glu Lys Glu Leu Glu Asn Glu Glu Leu Ala Lys Glu Ser           
225                 230                 235                 240           

gct att agt gat ttg act gag cag att act gct aag aag gct gaa gta    768
Ala Ile Ser Asp Leu Thr Glu Gln Ile Thr Ala Lys Lys Ala Glu Val           
                245                 250                 255               

gaa aaa tta act caa gat tta gct gct aag tct gct gaa att cag gaa    816
Glu Lys Leu Thr Gln Asp Leu Ala Ala Lys Ser Ala Glu Ile Gln Glu           
            260                 265                 270                   

aaa gaa gct gaa aaa gat cgc caa cag cat atg tac gaa gcg ttt atg    864
Lys Glu Ala Glu Lys Asp Arg Gln Gln His Met Tyr Glu Ala Phe Met           
        275                 280                 285                       

agc cag tac aaa gaa aaa gtt gag aaa caa gag caa gag ctt gct aag    912
Ser Gln Tyr Lys Glu Lys Val Glu Lys Gln Glu Gln Glu Leu Ala Lys           
    290                 295                 300                           

cta aaa caa ctt gaa acc atc aac aac aat cta tta ggt aat gct aag    960
Leu Lys Gln Leu Glu Thr Ile Asn Asn Asn Leu Leu Gly Asn Ala Lys           
305                 310                 315                 320           

gat atg ata gct aag ttg tct gct gaa aat gaa caa tta gca agc gac   1008
Asp Met Ile Ala Lys Leu Ser Ala Glu Asn Glu Gln Leu Ala Ser Asp           
                325                 330                 335               

aaa gca aaa ctt gaa gaa caa aac aag att tca gaa gcg agc cgt aaa   1056
Lys Ala Lys Leu Glu Glu Gln Asn Lys Ile Ser Glu Ala Ser Arg Lys           
            340                 345                 350                   

ggt ctt cgt cgt gac ttg gac gca tca cgt gaa gct aag aaa caa gtt   1104
Gly Leu Arg Arg Asp Leu Asp Ala Ser Arg Glu Ala Lys Lys Gln Val           
        355                 360                 365                       

gaa aaa gat tta gca aac ttg act gct gaa ctt gat aag gtt aaa gaa   1152
Glu Lys Asp Leu Ala Asn Leu Thr Ala Glu Leu Asp Lys Val Lys Glu           
    370                 375                 380                           

gat aaa caa att tca gac gca agc cgt aaa ggt ctt cgt cgt gac ttg   1200
Asp Lys Gln Ile Ser Asp Ala Ser Arg Lys Gly Leu Arg Arg Asp Leu           
385                 390                 395                 400           

gac gca tca cgt gaa gct aag aaa caa gtt gaa aaa gct tta gaa gaa   1248
Asp Ala Ser Arg Glu Ala Lys Lys Gln Val Glu Lys Ala Leu Glu Glu           
                405                 410                 415               

gca aac agc aaa tta gcg gct ctt gaa aaa ctt aac aaa gag ctt gaa   1296
Ala Asn Ser Lys Leu Ala Ala Leu Glu Lys Leu Asn Lys Glu Leu Glu           
            420                 425                 430                   

gaa agc aag aaa tta aca gaa aaa gaa aaa gct gag cta caa gcg aaa   1344
Glu Ser Lys Lys Leu Thr Glu Lys Glu Lys Ala Glu Leu Gln Ala Lys           
        435                 440                 445                       

ctt gaa gca gaa gca aaa gca ctc aaa gaa caa tta gcg aaa caa gct   1392
Leu Glu Ala Glu Ala Lys Ala Leu Lys Glu Gln Leu Ala Lys Gln Ala           
    450                 455                 460                           

gaa gaa ctt gca aaa cta aga gct gga aaa gca tca gac tca caa acc   1440
Glu Glu Leu Ala Lys Leu Arg Ala Gly Lys Ala Ser Asp Ser Gln Thr           
465                 470                 475                 480           

cct gat gca aaa cca gga aac aaa gtt gtt cca ggt aca ggt caa gca   1488
Pro Asp Ala Lys Pro Gly Asn Lys Val Val Pro Gly Thr Gly Gln Ala           
                485                 490                 495               

cca caa gca ggc aca aaa cct aac caa aac aaa gca cca atg aag gaa   1536
Pro Gln Ala Gly Thr Lys Pro Asn Gln Asn Lys Ala Pro Met Lys Glu           
            500                 505                 510                   

act aag aga cag tta cca tca aca ggt gaa gca gct aat cca ttc ttt   1584
Thr Lys Arg Gln Leu Pro Ser Thr Gly Glu Ala Ala Asn Pro Phe Phe           
        515                 520                 525                       

aca gcg gca gcc ctt act gtt atg gca aca gct gga gta gca gca gtt   1632
Thr Ala Ala Ala Leu Thr Val Met Ala Thr Ala Gly Val Ala Ala Val           
    530                 535                 540                           

gta aaa cgc aaa gaa gaa aac gaa                                   1656
Val Lys Arg Lys Glu Glu Asn Glu                                           
545                 550                                                   


<210>  2
<211>  552
<212>  PRT
<213>  Streptococcus pyogenes

<400>  2

Met Ala Lys Asn Thr Thr Asn Arg His Tyr Ser Leu Arg Lys Leu Lys 
1               5                   10                  15      


Thr Gly Thr Ala Ser Val Ala Val Ala Leu Thr Val Leu Gly Thr Gly 
            20                  25                  30          


Leu Val Ala Gly Gln Thr Val Lys Ala Ser Gln Thr Glu Pro Ser Gln 
        35                  40                  45              


Thr Asn Asn Arg Leu Tyr Gln Glu Arg Gln Arg Leu Gln Asp Leu Lys 
    50                  55                  60                  


Ser Lys Phe Gln Asp Leu Lys Asn Arg Ser Glu Gly Tyr Ile Gln Gln 
65                  70                  75                  80  


Tyr Tyr Asp Glu Glu Lys Asn Ser Gly Ser Asn Ser Asn Trp Tyr Ala 
                85                  90                  95      


Thr Tyr Leu Lys Glu Leu Asn Asp Glu Phe Glu Gln Ala Tyr Asn Glu 
            100                 105                 110         


Leu Ser Gly Asp Gly Val Lys Lys Leu Ala Ala Ser Leu Met Glu Glu 
        115                 120                 125             


Arg Val Ala Leu Arg Asp Glu Ile Asp Gln Ile Lys Lys Ile Ser Glu 
    130                 135                 140                 


Glu Leu Lys Asn Lys Leu Arg Ala Lys Glu Glu Glu Leu Lys Asn Lys 
145                 150                 155                 160 


Lys Glu Glu Arg Glu Leu Glu His Ala Ala Tyr Ala Ala Asp Ala Lys 
                165                 170                 175     


Lys His Glu Glu Tyr Val Lys Ser Met Ser Leu Val Leu Met Asp Lys 
            180                 185                 190         


Glu Glu Glu Arg His Lys Leu Glu Gln Ser Leu Asp Thr Ala Lys Ala 
        195                 200                 205             


Glu Leu Val Lys Lys Glu Gln Glu Leu Gln Leu Val Lys Gly Asn Leu 
    210                 215                 220                 


Asp Gln Lys Glu Lys Glu Leu Glu Asn Glu Glu Leu Ala Lys Glu Ser 
225                 230                 235                 240 


Ala Ile Ser Asp Leu Thr Glu Gln Ile Thr Ala Lys Lys Ala Glu Val 
                245                 250                 255     


Glu Lys Leu Thr Gln Asp Leu Ala Ala Lys Ser Ala Glu Ile Gln Glu 
            260                 265                 270         


Lys Glu Ala Glu Lys Asp Arg Gln Gln His Met Tyr Glu Ala Phe Met 
        275                 280                 285             


Ser Gln Tyr Lys Glu Lys Val Glu Lys Gln Glu Gln Glu Leu Ala Lys 
    290                 295                 300                 


Leu Lys Gln Leu Glu Thr Ile Asn Asn Asn Leu Leu Gly Asn Ala Lys 
305                 310                 315                 320 


Asp Met Ile Ala Lys Leu Ser Ala Glu Asn Glu Gln Leu Ala Ser Asp 
                325                 330                 335     


Lys Ala Lys Leu Glu Glu Gln Asn Lys Ile Ser Glu Ala Ser Arg Lys 
            340                 345                 350         


Gly Leu Arg Arg Asp Leu Asp Ala Ser Arg Glu Ala Lys Lys Gln Val 
        355                 360                 365             


Glu Lys Asp Leu Ala Asn Leu Thr Ala Glu Leu Asp Lys Val Lys Glu 
    370                 375                 380                 


Asp Lys Gln Ile Ser Asp Ala Ser Arg Lys Gly Leu Arg Arg Asp Leu 
385                 390                 395                 400 


Asp Ala Ser Arg Glu Ala Lys Lys Gln Val Glu Lys Ala Leu Glu Glu 
                405                 410                 415     


Ala Asn Ser Lys Leu Ala Ala Leu Glu Lys Leu Asn Lys Glu Leu Glu 
            420                 425                 430         


Glu Ser Lys Lys Leu Thr Glu Lys Glu Lys Ala Glu Leu Gln Ala Lys 
        435                 440                 445             


Leu Glu Ala Glu Ala Lys Ala Leu Lys Glu Gln Leu Ala Lys Gln Ala 
    450                 455                 460                 


Glu Glu Leu Ala Lys Leu Arg Ala Gly Lys Ala Ser Asp Ser Gln Thr 
465                 470                 475                 480 


Pro Asp Ala Lys Pro Gly Asn Lys Val Val Pro Gly Thr Gly Gln Ala 
                485                 490                 495     


Pro Gln Ala Gly Thr Lys Pro Asn Gln Asn Lys Ala Pro Met Lys Glu 
            500                 505                 510         


Thr Lys Arg Gln Leu Pro Ser Thr Gly Glu Ala Ala Asn Pro Phe Phe 
        515                 520                 525             


Thr Ala Ala Ala Leu Thr Val Met Ala Thr Ala Gly Val Ala Ala Val 
    530                 535                 540                 


Val Lys Arg Lys Glu Glu Asn Glu 
545                 550         


<210>  3
<211>  1653
<212>  DNA
<213>  Streptococcus pyogenes

<400>  3
atggctaaaa ataccacgaa tagacacgat tcgcttagaa aattaaaaac aggaacggct   60

tcagtagcag tagctttgac tgttttaggg acaggactgg tagcagggca gacagtaaaa  120

gcaaaccaaa cagaaccatc tcagaccaat aacagattat atcaagaaag acaacgttta  180

caggatttaa aaagtaaggt tcaagacctg aaaaatcgtt cagagggata cattcagcaa  240

tactacgacg aagaaaagaa cagtggaagt aactctaact ggtacgcaac ctacttaaaa  300

gaattaaatg acgaatttga acaagcttat aatgaactta gtggtgatgg tgtaaaaaaa  360

ttagctgcaa gtttgatgga agaaagagtc gctttaagag acgaaatcga tcagattaag  420

aaaatatcag aagaattaaa aaataagctg agagcaacag aagaagaatt aaaaaataaa  480

aaagaggaac gcgagcttga gcatgctgcc tatgcagtag atgcaaagaa acatgaagaa  540

tatgtcaaat ccatgtctct cgctctaatg gataaagaag agagcgctca tctactagag  600

caatcattag acacggctaa agctgagctt gttaaaaaag agcaagagtt acagttagtc  660

aaaggcaatc tagatcaaaa agaaaaagaa ctagaaaatg aagagctagc gaaagaaagt  720

gctattagtg atttgactga gcagattact gctaagaagg ctgaagtaga aaaattaact  780

caagatttag ctgctaagtc tgctgaaatt caggaaaaag aagctgaaaa agatcgccaa  840

cagcatatgt acgaagcgtt tatgagccag tacaaagaaa aagttgagaa acaagagcaa  900

gagcttgcta agctaaaaca acttgaaacc atcaacaaca atctattagg taatgctaag  960

gatatgatag ctaagttgtc tgctgaaaat gaacaattag caagcgacaa agcaaaactt 1020

gaagaacaaa acaagatttc agaagcgagc cgtaaaggtc ttcgtcgtga cttggacgca 1080

tcacgtgaag ctaagaaaca agttgaaaaa gatttagcaa acttgactgc tgaacttgat 1140

aaggttaaag aagataaaca aatttcagac gcaagccgta aaggtcttcg tcgtgacttg 1200

gacgcatcac gtgaagctaa gaaacaagtt gaaaaagctt tagaagaagc aaacagcaaa 1260

ttagcggctc ttgaaaaact taacaaagag cttgaagaaa gcaagaaatt aacagaaaaa 1320

gaaaaagctg agctacaagc gaaacttgaa gcagaagcaa aaacactcaa agaaaaatta 1380

gcgaaacaag ctgaagaact tgcaaaacta agagctggaa aagcatcaga ctcacaaacc 1440

cctgatgcaa aaccaggaaa caaagctgtt ccaggtaaag gtcaagcacc acaagcaggt 1500

acaaaaccta accaaaacaa agcaccaatg aaggaaacta agagacagtt accatcaaca 1560

ggtgaaacag ctaacccatt cttcacagcg gcagccctta ctgttatggc aacagctgga 1620

gtagcagttg tcaaacgcaa agaagaaaac taa                              1653


<210>  4
<211>  550
<212>  PRT
<213>  Streptococcus pyogenes

<400>  4

Met Ala Lys Asn Thr Thr Asn Arg His Asp Ser Leu Arg Lys Leu Lys 
1               5                   10                  15      


Thr Gly Thr Ala Ser Val Ala Val Ala Leu Thr Val Leu Gly Thr Gly 
            20                  25                  30          


Leu Val Ala Gly Gln Thr Val Lys Ala Asn Gln Thr Glu Pro Ser Gln 
        35                  40                  45              


Thr Asn Asn Arg Leu Tyr Gln Glu Arg Gln Arg Leu Gln Asp Leu Lys 
    50                  55                  60                  


Ser Lys Val Gln Asp Leu Lys Asn Arg Ser Glu Gly Tyr Ile Gln Gln 
65                  70                  75                  80  


Tyr Tyr Asp Glu Glu Lys Asn Ser Gly Ser Asn Ser Asn Trp Tyr Ala 
                85                  90                  95      


Thr Tyr Leu Lys Glu Leu Asn Asp Glu Phe Glu Gln Ala Tyr Asn Glu 
            100                 105                 110         


Leu Ser Gly Asp Gly Val Lys Lys Leu Ala Ala Ser Leu Met Glu Glu 
        115                 120                 125             


Arg Val Ala Leu Arg Asp Glu Ile Asp Gln Ile Lys Lys Ile Ser Glu 
    130                 135                 140                 


Glu Leu Lys Asn Lys Leu Arg Ala Thr Glu Glu Glu Leu Lys Asn Lys 
145                 150                 155                 160 


Lys Glu Glu Arg Glu Leu Glu His Ala Ala Tyr Ala Val Asp Ala Lys 
                165                 170                 175     


Lys His Glu Glu Tyr Val Lys Ser Met Ser Leu Ala Leu Met Asp Lys 
            180                 185                 190         


Glu Glu Ser Ala His Leu Leu Glu Gln Ser Leu Asp Thr Ala Lys Ala 
        195                 200                 205             


Glu Leu Val Lys Lys Glu Gln Glu Leu Gln Leu Val Lys Gly Asn Leu 
    210                 215                 220                 


Asp Gln Lys Glu Lys Glu Leu Glu Asn Glu Glu Leu Ala Lys Glu Ser 
225                 230                 235                 240 


Ala Ile Ser Asp Leu Thr Glu Gln Ile Thr Ala Lys Lys Ala Glu Val 
                245                 250                 255     


Glu Lys Leu Thr Gln Asp Leu Ala Ala Lys Ser Ala Glu Ile Gln Glu 
            260                 265                 270         


Lys Glu Ala Glu Lys Asp Arg Gln Gln His Met Tyr Glu Ala Phe Met 
        275                 280                 285             


Ser Gln Tyr Lys Glu Lys Val Glu Lys Gln Glu Gln Glu Leu Ala Lys 
    290                 295                 300                 


Leu Lys Gln Leu Glu Thr Ile Asn Asn Asn Leu Leu Gly Asn Ala Lys 
305                 310                 315                 320 


Asp Met Ile Ala Lys Leu Ser Ala Glu Asn Glu Gln Leu Ala Ser Asp 
                325                 330                 335     


Lys Ala Lys Leu Glu Glu Gln Asn Lys Ile Ser Glu Ala Ser Arg Lys 
            340                 345                 350         


Gly Leu Arg Arg Asp Leu Asp Ala Ser Arg Glu Ala Lys Lys Gln Val 
        355                 360                 365             


Glu Lys Asp Leu Ala Asn Leu Thr Ala Glu Leu Asp Lys Val Lys Glu 
    370                 375                 380                 


Asp Lys Gln Ile Ser Asp Ala Ser Arg Lys Gly Leu Arg Arg Asp Leu 
385                 390                 395                 400 


Asp Ala Ser Arg Glu Ala Lys Lys Gln Val Glu Lys Ala Leu Glu Glu 
                405                 410                 415     


Ala Asn Ser Lys Leu Ala Ala Leu Glu Lys Leu Asn Lys Glu Leu Glu 
            420                 425                 430         


Glu Ser Lys Lys Leu Thr Glu Lys Glu Lys Ala Glu Leu Gln Ala Lys 
        435                 440                 445             


Leu Glu Ala Glu Ala Lys Thr Leu Lys Glu Lys Leu Ala Lys Gln Ala 
    450                 455                 460                 


Glu Glu Leu Ala Lys Leu Arg Ala Gly Lys Ala Ser Asp Ser Gln Thr 
465                 470                 475                 480 


Pro Asp Ala Lys Pro Gly Asn Lys Ala Val Pro Gly Lys Gly Gln Ala 
                485                 490                 495     


Pro Gln Ala Gly Thr Lys Pro Asn Gln Asn Lys Ala Pro Met Lys Glu 
            500                 505                 510         


Thr Lys Arg Gln Leu Pro Ser Thr Gly Glu Thr Ala Asn Pro Phe Phe 
        515                 520                 525             


Thr Ala Ala Ala Leu Thr Val Met Ala Thr Ala Gly Val Ala Val Val 
    530                 535                 540                 


Lys Arg Lys Glu Glu Asn 
545                 550 
