                         SEQUENCE LISTING

<110>  Houghton, Michael
       Hockman, Darren
       Law, John
 
<120>  E1E2 HCV VACCINES AND METHODS OF USE

<130>  UALB-017WO

<150>  US 61/823,712
<151>  2013-05-15

<150>  US 61/887,229
<151>  2013-10-04

<160>  53    

<170>  PatentIn version 3.5

<210>  1
<211>  746
<212>  PRT
<213>  Hepatitis C virus

<400>  1

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr 
            180                 185                 190         


Gln Val Arg Asn Ser Ser Gly Leu Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Ala Asp Ala Ile Leu His Thr Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ala Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ala Val Thr Pro Thr Val Ala Thr Arg Asp Gly Lys Leu Pro Thr Thr 
                245                 250                 255     


Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Ala Leu Val Val Ala Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Ile Met Asp Met Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Glu 
    370                 375                 380                 


Thr His Val Thr Gly Gly Ser Ala Gly Arg Thr Thr Ala Gly Leu Val 
385                 390                 395                 400 


Gly Leu Leu Thr Pro Gly Ala Lys Gln Asn Ile Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Ser Thr Ala Leu Asn Cys Asn Glu Ser 
            420                 425                 430         


Leu Asn Thr Gly Trp Leu Ala Gly Leu Phe Tyr Gln His Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Leu Ala Ser Cys Arg Arg Leu Thr Asp 
    450                 455                 460                 


Phe Ala Gln Gly Trp Gly Pro Ile Ser Tyr Ala Asn Gly Ser Gly Leu 
465                 470                 475                 480 


Asp Glu Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Lys Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Arg Ser Gly Ala Pro Thr Tyr Ser 
        515                 520                 525             


Trp Gly Ala Asn Asp Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly Phe 
545                 550                 555                 560 


Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Val Gly Asn 
                565                 570                 575     


Asn Thr Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Met 
        595                 600                 605             


Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Ile Asn Tyr 
    610                 615                 620                 


Thr Ile Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Glu Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Glu Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Val Gly Ser Ser Ile Ala Ser Trp Ala Ile Lys Trp Glu Tyr Val Val 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ser Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ser Gln Ala Glu Ala 
            740                 745     


<210>  2
<211>  746
<212>  PRT
<213>  Hepatitis C virus

<400>  2

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Val Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr 
            180                 185                 190         


Gln Val Arg Asn Ser Ser Gly Ile Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Thr Ala Asp Thr Ile Leu His Ser Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ala Ser Lys Cys Trp Val 
225                 230                 235                 240 


Ala Leu Ala Pro Thr Val Ala Thr Arg Asp Gly Lys Leu Pro Thr Thr 
                245                 250                 255     


Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ala Gln 
                325                 330                 335     


Leu Leu Arg Val Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Glu 
    370                 375                 380                 


Thr Tyr Thr Thr Gly Gly Ser Val Ala Gln Ala Ala Phe Gly Leu Thr 
385                 390                 395                 400 


Ser Leu Phe Arg Pro Gly Pro Lys Gln Asp Ile Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Ala Ser 
            420                 425                 430         


Leu Asp Thr Gly Trp Val Ala Gly Leu Phe Tyr Tyr His Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Arg Ser Leu Ala Asp 
    450                 455                 460                 


Phe Asp Gln Gly Trp Gly Pro Ile Ser Tyr Ala Asn Gly Ser Gly Pro 
465                 470                 475                 480 


Glu His Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Gln Asn Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asn Lys Leu Gly Val Pro Thr Tyr Ser 
        515                 520                 525             


Trp Gly Ser Asn Glu Thr Asp Val Leu Val Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Ser Gly Phe 
545                 550                 555                 560 


Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Ala Gly Asn 
                565                 570                 575     


Arg Thr Leu His Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Leu 
        595                 600                 605             


Val His Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Tyr 
    610                 615                 620                 


Thr Met Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Glu Val Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Asp Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Thr Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Val Gly Ser Ser Ile Val Ser Trp Ala Ile Lys Trp Glu Tyr Val Ile 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys Ser Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ser Gln Ala Glu Ala 
            740                 745     


<210>  3
<211>  746
<212>  PRT
<213>  Hepatitis C virus

<400>  3

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Ser Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Phe 
            180                 185                 190         


Gln Val Arg Asn Ser Ser Gly Leu Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Thr Ala Asp Thr Ile Leu His Ser Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Asp Asn Thr Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ala Val Ala Pro Thr Val Ala Thr Arg Asp Gly Arg Leu Pro Thr Thr 
                245                 250                 255     


Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ala Gln 
                325                 330                 335     


Leu Leu Arg Val Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Ser Val Asp Ala Glu 
    370                 375                 380                 


Thr Tyr Thr Ser Gly Gly Ser Val Ala Arg Ala Thr Ala Gly Phe Ala 
385                 390                 395                 400 


Gly Ile Phe Asn Pro Gly Ala Lys Gln Asp Ile Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Ala Ser 
            420                 425                 430         


Leu Asp Thr Gly Trp Val Ala Gly Leu Phe Tyr Tyr His Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Lys Pro Leu Ala His 
    450                 455                 460                 


Phe Ala Gln Gly Trp Gly Pro Ile Ser Tyr Ala Asn Gly Ser Gly Pro 
465                 470                 475                 480 


Asp His Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Gln Asn Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asn Lys Leu Gly Ala Pro Thr Tyr Asn 
        515                 520                 525             


Trp Gly Ser Asn Asp Thr Asp Val Phe Ile Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Gly Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Ser Gly Phe 
545                 550                 555                 560 


Thr Lys Val Cys Gly Ala Pro Pro Cys Thr Ile Gly Gly Val Gly Asn 
                565                 570                 575     


Asn Thr Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Val Thr Pro Arg Phe Leu 
        595                 600                 605             


Val His Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Tyr 
    610                 615                 620                 


Thr Leu Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Glu Val Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Asp Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Thr Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Val Gly Ser Ser Leu Val Ser Trp Ala Ile Lys Trp Glu Tyr Val Ile 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys Ser Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ser Gln Ala Glu Ala 
            740                 745     


<210>  4
<211>  746
<212>  PRT
<213>  Hepatitis C virus

<400>  4

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr 
            180                 185                 190         


Gln Val Arg Asn Ser Ser Gly Leu Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Thr Ala Asp Thr Ile Leu His Ser Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Thr Ser Lys Cys Trp Val 
225                 230                 235                 240 


Ala Val Ala Pro Thr Val Ala Thr Arg Asp Gly Lys Leu Pro Thr Thr 
                245                 250                 255     


Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Ala Leu Val Thr Ala Gln 
                325                 330                 335     


Leu Leu Arg Val Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Ala Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Leu Val Leu Leu Leu Phe Ala Gly Val Asp Ala Glu 
    370                 375                 380                 


Thr Tyr Thr Thr Gly Gly Ser Val Ala Arg Thr Thr Arg Gly Leu Ala 
385                 390                 395                 400 


Ser Leu Leu Gln Val Gly Pro Lys Gln Asp Ile Arg Leu Ile His Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Ala Ser 
            420                 425                 430         


Leu Asp Thr Gly Trp Leu Ala Gly Leu Leu Tyr Tyr His Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Arg Pro Leu Ala Asp 
    450                 455                 460                 


Phe Asp Gln Gly Trp Gly Pro Ile Ser Tyr Ala Asn Gly Ser Gly Pro 
465                 470                 475                 480 


Glu His Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Gln Thr Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asn Lys Leu Gly Val Pro Thr Tyr Thr 
        515                 520                 525             


Trp Gly Ser Asn Asp Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly Phe 
545                 550                 555                 560 


Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Val Gly Asn 
                565                 570                 575     


Asn Thr Leu His Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Leu 
        595                 600                 605             


Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Tyr 
    610                 615                 620                 


Thr Leu Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Gln Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Asp Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Thr Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Val Gly Ser Ser Ile Val Ser Trp Ala Ile Lys Trp Glu Tyr Val Ile 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys Ser Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ser Gln Ala Glu Ala 
            740                 745     


<210>  5
<211>  746
<212>  PRT
<213>  Hepatitis C virus

<400>  5

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr 
            180                 185                 190         


Gln Val Arg Asn Ser Ser Gly Leu Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Thr Ala Asp Thr Ile Leu His Ser Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Asp Asn Ala Ser Arg Cys Trp Val 
225                 230                 235                 240 


Pro Val Ala Pro Thr Val Ala Thr Arg Asp Gly Lys Leu Pro Thr Thr 
                245                 250                 255     


Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Ser 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Val Ala Leu Val Met Ala Gln 
                325                 330                 335     


Leu Leu Arg Val Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Gln 
    370                 375                 380                 


Thr Tyr Val Thr Gly Gly Ser Ala Ala Arg Gly Ala Ser Gly Leu Ala 
385                 390                 395                 400 


Asn Leu Phe Thr Pro Gly Ala Lys Gln Asp Ile Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Ala Ser 
            420                 425                 430         


Leu Asp Thr Gly Trp Val Ala Gly Leu Phe Tyr Tyr His Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Lys Pro Leu Ala Asp 
    450                 455                 460                 


Phe Asp Gln Gly Trp Gly Pro Ile Arg His Ala Asn Gly Ser Gly Pro 
465                 470                 475                 480 


Glu His Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile 
                485                 490                 495     


Val Ser Ala Gln Thr Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asn Arg Leu Gly Val Pro Thr Tyr Ser 
        515                 520                 525             


Trp Gly Thr Asn Asp Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Ser Gly Phe 
545                 550                 555                 560 


Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Val Gly Asn 
                565                 570                 575     


Asn Thr Leu His Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Leu 
        595                 600                 605             


Val His Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Tyr 
    610                 615                 620                 


Thr Leu Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Glu Val Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Asp Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Thr Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Val Gly Ser Ser Ile Val Ser Trp Ala Ile Lys Trp Glu Tyr Val Ile 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys Ser Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ser Gln Ala Glu Ala 
            740                 745     


<210>  6
<211>  746
<212>  PRT
<213>  Hepatitis C virus

<400>  6

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Thr 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Glu Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr 
            180                 185                 190         


Gln Val Arg Asn Ser Ser Gly Leu Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Thr Lys Asp Thr Ile Leu His Ser Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Val Ser Lys Cys Trp Val 
225                 230                 235                 240 


Pro Val Ala Leu Thr Val Ala Thr Arg Asp Gly Asn Leu Pro Thr Thr 
                245                 250                 255     


Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Met Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ser Ala Leu Val Val Ala Gln 
                325                 330                 335     


Leu Leu Arg Val Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Leu Ala Tyr Phe Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Ser Val Asp Ala Gly 
    370                 375                 380                 


Thr His Val Thr Gly Gly Ser Ala Ala His Asp Val Ser Ala Leu Ala 
385                 390                 395                 400 


Gly Phe Phe Arg Arg Gly Ala Lys Gln Asn Ile Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Val Asn Arg Thr Ala Leu Asn Cys Asn Ala Ser 
            420                 425                 430         


Leu Asp Thr Gly Trp Val Ala Gly Leu Leu Tyr Tyr His Arg Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Arg Pro Leu Ala Asp 
    450                 455                 460                 


Phe Asp Gln Gly Trp Gly Pro Ile Thr Asn Val Asp Gly Gly Gly Ser 
465                 470                 475                 480 


Glu Tyr Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile 
                485                 490                 495     


Glu Pro Ala Gln Asn Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Lys Val Gly Val Pro Thr Tyr Asn 
        515                 520                 525             


Trp Gly Glu Asn Asp Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Ser Gly Phe 
545                 550                 555                 560 


Val Lys Val Cys Gly Ala Pro Pro Cys Ile Ile Gly Gly Ala Gly Asn 
                565                 570                 575     


Lys Thr Leu His Cys Pro Thr Asp Cys Phe Arg Lys His Pro Asp Ala 
            580                 585                 590         


Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys Leu 
        595                 600                 605             


Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Tyr 
    610                 615                 620                 


Thr Leu Phe Lys Ile Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Val Ala Ala Cys Asn Trp Thr Tyr Gly Glu Arg Cys Asn Leu Asp Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Thr Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Val Gly Ser Ser Ile Val Ser Trp Ala Ile Lys Trp Glu Tyr Val Ile 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys Ser Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ser Gln Ala Glu Ala 
            740                 745     


<210>  7
<211>  746
<212>  PRT
<213>  Hepatitis C virus

<400>  7

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr 
            180                 185                 190         


Gln Val Arg Asn Ser Ser Gly Leu Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Thr Ala Asp Thr Ile Leu His Ser Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ala Ser Lys Cys Trp Val 
225                 230                 235                 240 


Ala Val Ala Pro Thr Val Ala Thr Arg Asp Gly Thr Leu Pro Thr Thr 
                245                 250                 255     


Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Gly Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Ile Val Ala Gln 
                325                 330                 335     


Leu Leu Arg Val Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Glu 
    370                 375                 380                 


Thr His Val Thr Gly Gly Ser Ala Ala Gln Val Thr Ser Arg Val Ala 
385                 390                 395                 400 


Gly Phe Phe Asn Pro Gly Pro Lys Gln Asn Val Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Ala Ser 
            420                 425                 430         


Leu Asp Thr Gly Trp Val Ala Gly Leu Phe Tyr His Tyr Asn Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Arg Pro Leu Ala Asp 
    450                 455                 460                 


Phe Asp Gln Gly Trp Gly Pro Ile Ser Tyr Ala Asn Gly Ser Gly Pro 
465                 470                 475                 480 


Glu His Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Gln Asn Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asn Arg Leu Gly Val Pro Thr Tyr Asn 
        515                 520                 525             


Trp Gly Ser Asn Asp Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Ser Gly Phe 
545                 550                 555                 560 


Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Val Gly Asn 
                565                 570                 575     


Asn Thr Leu His Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Leu 
        595                 600                 605             


Val His Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Tyr 
    610                 615                 620                 


Thr Leu Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Glu Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Asp Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Thr Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Val Gly Ser Ser Ile Val Ser Trp Ala Ile Lys Trp Glu Tyr Val Ile 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys Ser Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ser Gln Ala Glu Ala 
            740                 745     


<210>  8
<211>  746
<212>  PRT
<213>  Hepatitis C virus

<400>  8

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Ser Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr 
            180                 185                 190         


Gln Val Arg Asn Ser Ser Gly Ile Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Thr Ala Asp Thr Ile Leu His Ser Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ala Ser Lys Cys Trp Val 
225                 230                 235                 240 


Ala Leu Ala Pro Thr Val Ala Thr Arg Asp Gly Arg Leu Pro Thr Thr 
                245                 250                 255     


Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ala Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala His 
    370                 375                 380                 


Thr Arg Val Thr Gly Gly Ser Ala Ala Arg Ala Thr Ala Arg Leu Thr 
385                 390                 395                 400 


Thr Leu Phe Ser Pro Gly Ala Lys Gln Asp Ile Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Ala Ser 
            420                 425                 430         


Leu Asp Thr Gly Trp Val Ala Gly Leu Phe Tyr Tyr His Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Arg Pro Leu Ala Asp 
    450                 455                 460                 


Phe Asp Gln Gly Trp Gly Pro Ile Ser Tyr Ala Asn Gly Ser Gly Pro 
465                 470                 475                 480 


Glu His Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile 
                485                 490                 495     


Ile Pro Ala Lys Thr Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Arg Ser Gly Ala Pro Thr Phe Asn 
        515                 520                 525             


Trp Gly Asp Asn Asp Thr Asp Val Leu Val Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Ser Gly Tyr 
545                 550                 555                 560 


Thr Lys Val Cys Gly Ala Pro Pro Cys Ile Ile Gly Gly Val Gly Asn 
                565                 570                 575     


Asn Thr Leu His Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Leu 
        595                 600                 605             


Val His Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Tyr 
    610                 615                 620                 


Thr Leu Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Glu Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asn Leu Asp Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Thr Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Val Gly Ser Ser Ile Val Ser Trp Ala Ile Lys Trp Glu Tyr Val Ile 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ser Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ser Gln Val Glu Ala 
            740                 745     


<210>  9
<211>  746
<212>  PRT
<213>  Hepatitis C virus

<400>  9

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr 
            180                 185                 190         


Gln Val Arg Asn Ser Ser Gly Leu Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Thr Ala Asp Thr Ile Leu His Ser Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ala Ser Lys Cys Trp Val 
225                 230                 235                 240 


Ala Val Thr Pro Thr Val Ala Thr Arg Asp Gly Arg Leu Pro Ala Thr 
                245                 250                 255     


Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Ile Phe Leu Val Gly 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ala Gln 
                325                 330                 335     


Leu Leu Arg Val Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Gly 
    370                 375                 380                 


Thr His Val Thr Gly Gly Ser Ala Ala Lys Asp Thr Ser Gly Phe Thr 
385                 390                 395                 400 


Ser Leu Phe Arg Ile Gly Ala Arg Gln Asn Ile Gln Leu Ile Asn Ser 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Glu Ser 
            420                 425                 430         


Leu Asp Thr Gly Trp Val Ala Gly Leu Leu Tyr Tyr His Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Arg Ser Leu Ala Asp 
    450                 455                 460                 


Phe Asp Gln Gly Trp Gly Pro Ile Ser Tyr Ala Asn Gly Ser Gly Pro 
465                 470                 475                 480 


Glu His Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Gln Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Lys Ser Gly Ala Pro Thr Tyr Asn 
        515                 520                 525             


Trp Gly Cys Asn Glu Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Ser Gly Phe 
545                 550                 555                 560 


Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Val Gly Asn 
                565                 570                 575     


Asn Thr Leu His Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Leu 
        595                 600                 605             


Val His Tyr Ala Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Tyr 
    610                 615                 620                 


Thr Leu Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Asp Val Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asn Leu Asp Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Val Gly Ser Ser Ile Val Ser Trp Ala Ile Lys Trp Glu Tyr Val Ile 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys Ser Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ser Gln Ala Glu Ala 
            740                 745     


<210>  10
<211>  746
<212>  PRT
<213>  Hepatitis C virus

<400>  10

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr 
            180                 185                 190         


Gln Val Arg Asn Ser Ser Gly Leu Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Thr Ala Asp Thr Ile Leu His Ser Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ala Ser Lys Cys Trp Val 
225                 230                 235                 240 


Ala Val Thr Pro Thr Val Ala Thr Arg Asp Gly Arg Leu Pro Ala Thr 
                245                 250                 255     


Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Ile Phe Leu Val Gly 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ala Gln 
                325                 330                 335     


Leu Leu Arg Val Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Gly 
    370                 375                 380                 


Thr His Val Thr Gly Gly Ser Ala Ala Lys Asp Thr Ser Gly Phe Thr 
385                 390                 395                 400 


Ser Leu Phe Arg Ile Gly Ala Arg Gln Asn Ile Gln Leu Ile Asn Ser 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Glu Ser 
            420                 425                 430         


Leu Asp Thr Gly Trp Val Ala Gly Leu Leu Tyr Tyr His Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Arg Ser Leu Ala Asp 
    450                 455                 460                 


Phe Asp Gln Gly Trp Gly Pro Ile Ser Tyr Ala Asn Gly Ser Gly Pro 
465                 470                 475                 480 


Glu His Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Gln Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Lys Ser Gly Ala Pro Thr Tyr Asn 
        515                 520                 525             


Trp Gly Cys Asn Glu Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Ser Gly Phe 
545                 550                 555                 560 


Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Val Gly Asn 
                565                 570                 575     


Asn Thr Leu His Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Leu 
        595                 600                 605             


Val His Tyr Ala Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Tyr 
    610                 615                 620                 


Thr Leu Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Asp Val Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asn Leu Asp Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Val Gly Ser Ser Ile Val Ser Trp Ala Ile Lys Trp Glu Tyr Val Ile 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys Ser Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ser Gln Ala Glu Ala 
            740                 745     


<210>  11
<211>  746
<212>  PRT
<213>  Hepatitis C virus

<400>  11

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr 
            180                 185                 190         


Gln Val Arg Asn Ser Ser Gly Leu Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Thr Ala Asp Thr Ile Leu His Ser Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ala Ser Lys Cys Trp Val 
225                 230                 235                 240 


Ala Val Thr Pro Thr Val Ala Thr Arg Asp Gly Arg Leu Pro Ala Thr 
                245                 250                 255     


Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Ile Phe Leu Val Gly 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ala Gln 
                325                 330                 335     


Leu Leu Arg Val Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Gly 
    370                 375                 380                 


Thr His Val Thr Gly Gly Ser Ala Ala Lys Asp Thr Ser Gly Phe Thr 
385                 390                 395                 400 


Ser Leu Phe Arg Ile Gly Ala Arg Gln Asn Ile Gln Leu Ile Asn Ser 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Glu Ser 
            420                 425                 430         


Leu Asp Thr Gly Trp Val Ala Gly Leu Leu Tyr Tyr His Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Arg Ser Leu Ala Asp 
    450                 455                 460                 


Phe Asp Gln Gly Trp Gly Pro Ile Ser Tyr Ala Asn Gly Ser Gly Pro 
465                 470                 475                 480 


Glu His Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Gln Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Lys Ser Gly Ala Pro Thr Tyr Asn 
        515                 520                 525             


Trp Gly Cys Asn Glu Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Ser Gly Phe 
545                 550                 555                 560 


Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Val Gly Asn 
                565                 570                 575     


Asn Thr Leu His Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Leu 
        595                 600                 605             


Val His Tyr Ala Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Tyr 
    610                 615                 620                 


Thr Leu Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Asp Val Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asn Leu Asp Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Val Gly Ser Ser Ile Val Ser Trp Ala Ile Lys Trp Glu Tyr Val Ile 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys Ser Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ser Gln Ala Glu Ala 
            740                 745     


<210>  12
<211>  746
<212>  PRT
<213>  Hepatitis C virus

<400>  12

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr 
            180                 185                 190         


Gln Val Arg Asn Ser Ser Gly Leu Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Thr Ala Asp Ser Ile Leu His Ser Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ala Ser Lys Cys Trp Val 
225                 230                 235                 240 


Ala Val Ala Pro Thr Val Ala Thr Arg Asp Gly Lys Leu Pro Ala Thr 
                245                 250                 255     


Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Ser 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ser Gln 
                325                 330                 335     


Leu Leu Arg Val Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Glu 
    370                 375                 380                 


Thr His Thr Thr Gly Gly Ser Ala Ala Tyr Ala Thr Ser Gly Phe Val 
385                 390                 395                 400 


Gly Leu Phe Arg Gln Gly Ala Lys Gln Asn Ile Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Val Asn Arg Thr Ala Leu Asn Cys Asn Ala Ser 
            420                 425                 430         


Leu Asp Thr Gly Trp Val Ala Gly Leu Phe Tyr Tyr His Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Leu Ala Ser Cys Lys Pro Leu Ala Asn 
    450                 455                 460                 


Phe Asp Gln Gly Trp Gly Ser Ile Ser Tyr Thr Asn Gly Ser Gly Pro 
465                 470                 475                 480 


Glu His Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Gln Asn Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Ala Pro Thr Phe Asn 
        515                 520                 525             


Trp Gly Glu Asn Glu Ser Asp Val Phe Val Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Ser Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Ser Gly Phe 
545                 550                 555                 560 


Thr Lys Val Cys Gly Ala Pro Pro Cys Asn Ile Gly Gly Val Gly Asn 
                565                 570                 575     


Asn Thr Leu His Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Val Thr Pro Arg Cys Leu 
        595                 600                 605             


Val His Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Leu Asn Tyr 
    610                 615                 620                 


Ser Leu Phe Lys Val Arg Met Tyr Val Gly Gly Ile Glu His Arg Leu 
625                 630                 635                 640 


Glu Val Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asn Leu Asp Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Thr Thr Thr Gln Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Thr Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Val Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Val Gly Ser Ser Ile Val Ser Trp Ala Ile Lys Trp Glu Tyr Val Ile 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys Ser Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ser Gln Ala Glu Ala 
            740                 745     


<210>  13
<211>  746
<212>  PRT
<213>  Hepatitis C virus

<400>  13

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr 
            180                 185                 190         


Gln Val Arg Asn Ser Ser Gly Leu Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Thr Ala Asp Thr Ile Leu His Ser Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ala Ser Lys Cys Trp Val 
225                 230                 235                 240 


Ala Val Ala Pro Thr Val Ala Thr Arg Asp Gly Arg Leu Pro Thr Thr 
                245                 250                 255     


Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg His His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ala Gln 
                325                 330                 335     


Leu Leu Arg Val Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Thr 
    370                 375                 380                 


Thr His Thr Thr Gly Gly Ala Val Ala His Asn Thr Arg Met Phe Thr 
385                 390                 395                 400 


Ser Ile Phe Ser Leu Gly Pro Arg Gln Glu Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Ala Ser 
            420                 425                 430         


Leu Glu Thr Gly Trp Ile Ala Gly Leu Leu Tyr Ala Asn Arg Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Lys Pro Leu Ala Asp 
    450                 455                 460                 


Phe Asp Gln Gly Trp Gly Pro Ile Ser Tyr Ala Asn Gly Ser Gly Pro 
465                 470                 475                 480 


Glu His Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Gln Asn Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Thr Pro Thr Tyr Asp 
        515                 520                 525             


Trp Gly Ser Asn Asp Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Ala Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Ser Gly Tyr 
545                 550                 555                 560 


Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Val Ser Asn 
                565                 570                 575     


Asn Thr Leu His Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Leu 
        595                 600                 605             


Val His Tyr Ala Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Tyr 
    610                 615                 620                 


Thr Leu Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Glu Val Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asn Leu Asp Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Thr Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Val Gly Ser Ser Ile Val Ser Trp Ala Val Lys Trp Glu Tyr Val Ile 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys Ser Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ser Gln Ala Glu Ala 
            740                 745     


<210>  14
<211>  746
<212>  PRT
<213>  Hepatitis C virus

<400>  14

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Gln Pro Glu Gly Arg Ala Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Ile Pro Ala Ser Ala Tyr 
            180                 185                 190         


Glu Val Arg Asn Val Ser Gly Val Tyr His Val Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Ala Ser Ile Val Tyr Glu Ala Ala Asp Met Ile Met His Thr Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Asn Asn Ser Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ala Leu Thr Pro Thr Leu Ala Ala Arg Asn Ala Ser Val Pro Thr Thr 
                245                 250                 255     


Thr Ile Arg Arg His Val Asp Leu Leu Val Gly Ala Ala Ala Leu Cys 
            260                 265                 270         


Ser Ala Met Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Ala 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Glu Thr Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Val Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Ala Leu Val Val Ser Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Val Val Asp Met Val Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Leu Ala Tyr Tyr Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Ile Val Met Leu Leu Phe Ala Gly Val Asp Gly Gly 
    370                 375                 380                 


Thr Tyr Val Thr Gly Gly Thr Met Ala Lys Asn Thr Leu Gly Ile Thr 
385                 390                 395                 400 


Ser Leu Phe Ser Pro Gly Ser Ser Gln Lys Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Asn Thr Gly Phe Leu Ala Ala Leu Phe Tyr Val His Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Ser Pro Ile Asp Ala 
    450                 455                 460                 


Phe Ala Gln Gly Trp Gly Pro Ile Thr Tyr Asn Glu Ser His Ser Ser 
465                 470                 475                 480 


Asp Gln Arg Pro Tyr Cys Trp His Tyr Ala Pro Arg Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Ala Gln Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Arg Phe Gly Val Pro Thr Tyr Ser 
        515                 520                 525             


Trp Gly Glu Asn Glu Thr Asp Val Leu Leu Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Gln Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly Phe 
545                 550                 555                 560 


Thr Lys Thr Cys Gly Gly Pro Pro Cys Asn Ile Gly Gly Ile Gly Asn 
                565                 570                 575     


Lys Thr Leu Thr Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Thr Lys Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys Leu 
        595                 600                 605             


Val His Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Phe 
    610                 615                 620                 


Thr Ile Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Glu Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asn Leu Glu Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Glu Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Val Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Ile Gly Ser Ala Val Val Ser Phe Ala Ile Lys Trp Glu Tyr Val Leu 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ala Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ala Gln Ala Glu Ala 
            740                 745     


<210>  15
<211>  746
<212>  PRT
<213>  Hepatitis C virus

<400>  15

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Gln Pro Glu Gly Arg Ala Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Met Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Val Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Ile Pro Ala Ser Ala Tyr 
            180                 185                 190         


Glu Val Arg Asn Val Ser Gly Ile Tyr His Val Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Ala Asp Met Ile Met His Thr Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ser Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ala Leu Thr Pro Thr Leu Ala Ala Arg Asn Ala Ser Val Pro Thr Thr 
                245                 250                 255     


Ala Ile Arg Arg His Val Asp Leu Leu Val Gly Ala Ala Ala Phe Cys 
            260                 265                 270         


Ser Ala Met Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Ser 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Glu Thr Ile Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Val Ser Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ser Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Ile Val Asp Met Val Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Leu Ala Tyr Tyr Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Ile Val Met Leu Leu Phe Ala Gly Val Asp Gly Glu 
    370                 375                 380                 


Thr Arg Val Thr Gly Gly Gln Ile Ala Arg Asn Ala Tyr Ser Leu Thr 
385                 390                 395                 400 


Thr Leu Phe Ser Ser Gly Ser Ala Gln Asn Ile Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Asn Thr Gly Phe Leu Ala Ala Leu Phe Tyr Thr His Lys Phe Asn 
        435                 440                 445             


Ala Ser Gly Cys Pro Glu Arg Leu Ala Ser Cys Arg Pro Ile Asp Lys 
    450                 455                 460                 


Phe Asp Gln Gly Trp Gly Pro Ile Thr Tyr Ala Glu Gln Gly Gly Gln 
465                 470                 475                 480 


Asp Gln Arg Pro Tyr Cys Trp His Tyr Ala Pro Lys Pro Cys Gly Ile 
                485                 490                 495     


Val Ser Ala Ser Lys Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Arg Phe Gly Val Pro Thr Tyr Ser 
        515                 520                 525             


Trp Gly Glu Asn Glu Thr Asp Val Leu Leu Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Gln Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Gly Thr Gly Phe 
545                 550                 555                 560 


Thr Lys Thr Cys Gly Gly Pro Pro Cys Asn Ile Gly Gly Gly Gly Asn 
                565                 570                 575     


Asn Thr Leu Thr Cys Pro Thr Asp Cys Phe Arg Lys His Pro Ala Ala 
            580                 585                 590         


Thr Tyr Thr Lys Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys Leu 
        595                 600                 605             


Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Ala Asn Phe 
    610                 615                 620                 


Thr Ile Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Asp Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asn Leu Glu Asp 
                645                 650                 655     


Arg Asp Arg Leu Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Glu Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Ile Gly Ser Ala Val Val Ser Phe Ala Ile Lys Trp Asp Tyr Ile Val 
705                 710                 715                 720 


Ile Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ala Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ala Gln Ala Glu Ala 
            740                 745     


<210>  16
<211>  747
<212>  PRT
<213>  Hepatitis C virus

<400>  16

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Ile Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Ala Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Met Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Leu Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Gly Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala His 
            180                 185                 190         


Glu Val Arg Asn Ala Ser Gly Val Tyr His Val Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Ser Ser Ile Val Phe Glu Ala Ala Asp Leu Ile Met His Thr Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ser Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ala Leu Thr Pro Thr Leu Ala Ala Arg Asn Ala Thr Ile Pro Thr Thr 
                245                 250                 255     


Thr Ile Arg His His Val Asp Leu Leu Val Gly Ala Ala Ala Leu Cys 
            260                 265                 270         


Ser Ala Met Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Ser 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Ala Thr Leu Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Ala Ser Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ser Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Val Ile Asp Met Val Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Leu Ala Tyr Tyr Ser Met Ala Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Ile Val Met Leu Leu Phe Ala Gly Val Asp Gly His 
    370                 375                 380                 


Thr Leu Thr Thr Gly Gly His Ala Ala Arg Leu Thr Ser Gly Phe Ala 
385                 390                 395                 400 


Gly Leu Phe Thr Pro Gly Pro Ser Gln Arg Ile Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Gln Thr Gly Phe Leu Ala Ala Leu Phe Tyr Ala His Arg Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Arg Ser Ile Asp Lys 
    450                 455                 460                 


Phe Asp Gln Gly Trp Gly Pro Ile Thr Tyr Ala Glu Pro Thr Lys Asp 
465                 470                 475                 480 


Pro Asp Gln Arg Pro Tyr Cys Trp His Tyr Pro Pro Gln Gln Cys Gly 
                485                 490                 495     


Ile Val Pro Ala Ser Gln Val Cys Gly Pro Val Tyr Cys Phe Thr Pro 
            500                 505                 510         


Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Asn Pro Thr Tyr 
        515                 520                 525             


Ser Trp Gly Glu Asn Asp Thr Asp Val Leu Leu Leu Asn Asn Thr Arg 
    530                 535                 540                 


Pro Pro Gln Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly 
545                 550                 555                 560 


Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Asn Ile Gly Gly Val Gly 
                565                 570                 575     


Asn Asn Thr Leu Thr Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu 
            580                 585                 590         


Ala Thr Tyr Ser Lys Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys 
        595                 600                 605             


Met Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn 
    610                 615                 620                 


Phe Ser Ile Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg 
625                 630                 635                 640 


Leu Asn Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asn Leu Asp 
                645                 650                 655     


Asp Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Glu 
            660                 665                 670         


Trp Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr 
        675                 680                 685             


Gly Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr 
    690                 695                 700                 


Gly Ile Gly Ser Ala Val Val Ser Phe Ala Ile Lys Trp Glu Tyr Val 
705                 710                 715                 720 


Val Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ala Cys Leu 
                725                 730                 735     


Trp Met Met Leu Leu Ile Ala Gln Ala Glu Ala 
            740                 745         


<210>  17
<211>  746
<212>  PRT
<213>  Hepatitis C virus

<400>  17

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg His Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Ile Pro Ala Ser Ala Tyr 
            180                 185                 190         


Glu Val Arg Asn Val Ser Gly Val Tyr His Val Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Ala Asp Val Ile Met His Thr Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Gln Asp Gly Asn Thr Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ala Leu Thr Pro Thr Leu Ala Ala Arg Asn Ala Ser Val Pro Val Thr 
                245                 250                 255     


Ala Ile Arg Arg His Val Asp Leu Leu Val Gly Thr Ala Ala Phe Cys 
            260                 265                 270         


Ser Ala Met Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Pro Val Ser 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Gln Thr Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Ile Ser Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Ala Leu Val Val Ser Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Ile Val Asp Met Val Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Leu Ala Tyr Tyr Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Met Ile Val Leu Leu Leu Phe Ala Gly Val Asp Gly Thr 
    370                 375                 380                 


Thr His Thr Thr Gly Gly Ala Ala Ala Arg Ala Thr Gln Gly Phe Thr 
385                 390                 395                 400 


Ser Phe Phe Ser Leu Gly Pro Ser Gln Lys Ile Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Gln Thr Gly Phe Leu Ala Ala Leu Phe Tyr Thr Tyr Arg Phe Asn 
        435                 440                 445             


Ala Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Arg Pro Ile Asp Lys 
    450                 455                 460                 


Phe Asp Gln Gly Trp Gly Pro Ile Thr Tyr Ala Glu Pro Asp Ser Ser 
465                 470                 475                 480 


Asp Gln Arg Pro Tyr Cys Trp His Tyr Ala Pro Arg Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Ser Gln Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Arg Phe Gly Val Pro Thr Tyr Thr 
        515                 520                 525             


Trp Gly Glu Asn Glu Thr Asp Val Leu Leu Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly Phe 
545                 550                 555                 560 


Thr Lys Thr Cys Gly Gly Pro Pro Cys Asn Ile Gly Gly Ala Gly Asn 
                565                 570                 575     


Thr Thr Leu Thr Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Thr Lys Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys Leu 
        595                 600                 605             


Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Ala Val Asn Phe 
    610                 615                 620                 


Thr Ile Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Asn Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Glu Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Glu Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Ile Gly Ser Ala Val Ile Pro Phe Ala Ile Lys Trp Glu Tyr Val Leu 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ala Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ala Gln Ala Glu Ala 
            740                 745     


<210>  18
<211>  746
<212>  PRT
<213>  Hepatitis C virus

<400>  18

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Met Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Asn Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Thr Pro Ala Ser Ala Tyr 
            180                 185                 190         


Glu Val Arg Asn Val Ser Gly Ile Tyr His Val Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Ala Asp Ile Ile Met His Thr Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Lys Asn Ile Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ala Leu Thr Pro Thr Leu Ala Ala Arg Asn Ile Ser Val Pro Thr Ala 
                245                 250                 255     


Thr Ile Arg Arg His Val Asp Leu Leu Val Gly Thr Ala Ala Phe Cys 
            260                 265                 270         


Ser Ala Met Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Ser 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Trp His Glu Thr Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Leu Tyr Pro Gly His Val Ser Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Ala Leu Val Val Ser Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Val Val Asp Met Val Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Leu Ala Tyr Tyr Ser Met Ile Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Ile Val Met Leu Leu Phe Ala Gly Ala Asp Gly Thr 
    370                 375                 380                 


Thr His Val Thr Gly Gly Val Gln Ala His Gly Ala Tyr Gly Leu Ala 
385                 390                 395                 400 


Ser Leu Phe Asn Val Gly Pro His Gln Lys Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Thr 
            420                 425                 430         


Leu Gln Thr Gly Phe Leu Ala Ala Leu Phe Tyr Lys His Arg Phe Asn 
        435                 440                 445             


Ala Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Arg Pro Ile Asp Lys 
    450                 455                 460                 


Phe Ala Gln Gly Trp Gly Pro Ile Thr Tyr Ala Glu Pro Asp Arg Leu 
465                 470                 475                 480 


Asp Gln Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Leu Glu Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Arg Phe Gly Val Pro Thr Tyr Ser 
        515                 520                 525             


Trp Gly Glu Asn Glu Thr Asp Val Leu Leu Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Gln Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly Tyr 
545                 550                 555                 560 


Thr Lys Thr Cys Gly Gly Pro Pro Cys Asn Ile Gly Gly Val Gly Asn 
                565                 570                 575     


Asn Thr Leu Thr Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Thr Lys Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys Leu 
        595                 600                 605             


Val His Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Phe 
    610                 615                 620                 


Thr Ile Phe Lys Val Arg Met Tyr Val Gly Gly Ile Glu His Arg Leu 
625                 630                 635                 640 


Asp Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Glu Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Glu Trp 
            660                 665                 670         


Gln Ile Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Arg Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Ile Gly Ser Ala Val Val Ser Phe Ala Ile Lys Trp Glu Tyr Val Leu 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ala Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ala Gln Ala Glu Ala 
            740                 745     


<210>  19
<211>  746
<212>  PRT
<213>  Hepatitis C virus

<400>  19

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Ile Pro Ala Ser Ala Tyr 
            180                 185                 190         


Glu Val Arg Asn Val Ser Gly Ile Tyr His Val Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Ala Asp Val Ile Met His Ala Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Asn Asn Ser Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ala Leu Thr Pro Thr Leu Ala Ala Arg Asn Ala Ser Val Pro Thr Thr 
                245                 250                 255     


Thr Leu Arg Arg His Val Asp Leu Leu Val Gly Thr Ala Ala Phe Cys 
            260                 265                 270         


Ser Ala Met Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Ile Ser 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Glu Thr Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Val Ser Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Ala Leu Val Val Ser Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Val Met Asp Met Val Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Leu Ala Tyr Tyr Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Ile Val Met Leu Leu Phe Ala Gly Val Asp Gly His 
    370                 375                 380                 


Thr Arg Val Thr Gly Gly Val Gln Gly His Val Thr Ser Thr Leu Thr 
385                 390                 395                 400 


Ser Leu Phe Arg Pro Gly Ala Ser Gln Lys Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Lys Thr Gly Phe Leu Ala Ala Leu Phe Tyr Thr His Lys Phe Asn 
        435                 440                 445             


Ala Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Arg Ser Ile Asp Lys 
    450                 455                 460                 


Phe Asp Gln Gly Trp Gly Pro Ile Thr Tyr Ala Gln Pro Asp Asn Ser 
465                 470                 475                 480 


Asp Gln Arg Pro Tyr Cys Trp His Tyr Ala Pro Arg Gln Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Ser Gln Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Arg Phe Gly Ala Pro Thr Tyr Asn 
        515                 520                 525             


Trp Gly Asp Asn Glu Thr Asp Val Leu Leu Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro His Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly Phe 
545                 550                 555                 560 


Thr Lys Thr Cys Gly Gly Pro Pro Cys Asn Ile Arg Gly Val Gly Asn 
                565                 570                 575     


Asn Thr Leu Thr Cys Pro Thr Asp Cys Phe Arg Lys His Pro Asp Ala 
            580                 585                 590         


Thr Tyr Thr Lys Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys Leu 
        595                 600                 605             


Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Phe 
    610                 615                 620                 


Thr Ile Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Asp Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Glu Asp 
                645                 650                 655     


Arg Asp Arg Ala Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Glu Trp 
            660                 665                 670         


Gln Ile Leu Pro Cys Ser Tyr Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Ile Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Ile Gly Ser Ala Val Val Ser Ile Ala Ile Lys Trp Glu Tyr Val Val 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ala Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ala Gln Ala Glu Ala 
            740                 745     


<210>  20
<211>  746
<212>  PRT
<213>  Hepatitis C virus

<400>  20

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asp Glu Gly Met Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Asn Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Thr Pro Ala Ser Ala Tyr 
            180                 185                 190         


Glu Val Arg Asn Val Ser Gly Ile Tyr His Val Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Ala Asp Ile Ile Met His Thr Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Lys Asn Thr Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ala Leu Thr Pro Thr Leu Ala Ala Arg Asn Ile Ser Val Pro Thr Thr 
                245                 250                 255     


Thr Ile Arg Arg His Val Asp Leu Leu Val Gly Thr Ala Ala Phe Cys 
            260                 265                 270         


Ser Ala Met Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Ser 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Glu Thr Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Leu Tyr Pro Gly His Val Ser Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Ala Leu Val Val Ser Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Ile Val Asp Met Val Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Leu Ala Tyr Tyr Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Ile Val Met Leu Leu Phe Ala Gly Ala Asp Gly Thr 
    370                 375                 380                 


Thr His Val Thr Gly Gly Val Gln Ala His Gly Ala Tyr Gly Leu Ala 
385                 390                 395                 400 


Ser Leu Phe Asn Val Gly Pro His Gln Lys Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Thr 
            420                 425                 430         


Leu Gln Thr Gly Phe Leu Ala Ala Leu Phe Tyr Lys His Arg Phe Asn 
        435                 440                 445             


Ala Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Arg Pro Ile Asp Lys 
    450                 455                 460                 


Phe Ala Gln Gly Trp Gly Pro Ile Thr Tyr Ala Glu Pro Asp Arg Leu 
465                 470                 475                 480 


Asp Gln Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Leu Glu Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Arg Phe Gly Val Pro Thr Tyr Ser 
        515                 520                 525             


Trp Gly Glu Asn Glu Thr Asp Val Leu Leu Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Gln Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Asn Thr Gly Phe 
545                 550                 555                 560 


Thr Lys Thr Cys Gly Gly Pro Pro Cys Asn Ile Gly Gly Val Gly Asn 
                565                 570                 575     


Asn Thr Leu Thr Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Thr Lys Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys Leu 
        595                 600                 605             


Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Phe 
    610                 615                 620                 


Thr Val Phe Lys Val Arg Met Tyr Val Gly Gly Ile Glu His Arg Leu 
625                 630                 635                 640 


Asp Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Glu Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Glu Trp 
            660                 665                 670         


Gln Ile Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Arg Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Ile Gly Ser Ala Val Val Ser Phe Ala Ile Lys Trp Glu Tyr Ile Leu 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ala Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ala Gln Ala Glu Ala 
            740                 745     


<210>  21
<211>  746
<212>  PRT
<213>  Hepatitis C virus

<400>  21

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Gln Pro Glu Gly Arg Ala Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Ile Pro Ala Ser Ala Tyr 
            180                 185                 190         


Glu Val Arg Asn Val Ser Gly Val Tyr His Val Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Ala Asp Met Ile Met His Thr Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Asp Asn Ser Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ala Leu Thr Pro Thr Leu Ala Ala Arg Asn Ser Ser Val Pro Thr Thr 
                245                 250                 255     


Thr Ile Arg Arg His Val Asp Leu Leu Val Gly Ala Ala Ala Phe Cys 
            260                 265                 270         


Ser Ala Met Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Ile Ser 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg Tyr Glu Thr Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Leu Tyr Pro Gly His Val Ser Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ser Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Val Val Asp Met Val Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Leu Ala Tyr Tyr Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Ile Val Met Leu Leu Phe Ala Gly Val Asp Gly Asn 
    370                 375                 380                 


Thr Arg Val Ser Gly Gly Glu Ala Ala Lys Asn Thr Met Gly Phe Ala 
385                 390                 395                 400 


Ser Leu Phe Val Ser Gly Pro Ser Gln Lys Ile Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asp Asp Ser 
            420                 425                 430         


Leu His Thr Gly Phe Leu Ala Ala Leu Phe Tyr Ala His Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Ser Gly Arg Met Ala Ser Cys Arg Pro Ile Asp Glu 
    450                 455                 460                 


Phe Ala Gln Gly Trp Gly Pro Ile Thr His Gly Val Pro Asp Asn Leu 
465                 470                 475                 480 


Asp Gln Arg Pro Tyr Cys Trp His Tyr Ala Pro Arg Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Ser Gln Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Arg Phe Gly Ala Pro Thr Tyr Ser 
        515                 520                 525             


Trp Gly Glu Asn Glu Thr Asp Val Leu Leu Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Gln Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly Phe 
545                 550                 555                 560 


Thr Lys Thr Cys Gly Gly Pro Pro Cys Asn Ile Gly Gly Val Gly Asn 
                565                 570                 575     


Asn Thr Leu Thr Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Thr Lys Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys Met 
        595                 600                 605             


Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Phe 
    610                 615                 620                 


Thr Ile Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Asp Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asn Val Glu Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Glu Trp 
            660                 665                 670         


Gln Ile Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Val Gly Ser Val Val Val Ser Val Val Ile Arg Trp Glu Tyr Val Val 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ala Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ala Gln Ala Glu Ala 
            740                 745     


<210>  22
<211>  746
<212>  PRT
<213>  Hepatitis C virus

<400>  22

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Gln Pro Glu Gly Arg Ala Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Met Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Ile Pro Ala Ser Ala Tyr 
            180                 185                 190         


Glu Val Arg Asn Val Ser Gly Met Tyr His Val Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Ala Asp Met Ile Leu His Ala Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Asn Asn Ser Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ala Leu Thr Pro Thr Leu Ala Ala Arg Asn Ala Ser Val Pro Thr Thr 
                245                 250                 255     


Ala Ile Arg Arg His Val Asp Leu Leu Val Gly Ala Ala Ala Phe Cys 
            260                 265                 270         


Ser Ala Met Tyr Val Gly Asp Leu Cys Gly Ser Val Leu Leu Val Ser 
        275                 280                 285             


Gln Ile Phe Thr Phe Ser Pro Arg Arg His Glu Thr Met Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ser Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Ile Val Asp Met Val Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Leu Ala Tyr Tyr Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Ile Val Met Leu Leu Phe Ala Gly Val Asp Gly Gly 
    370                 375                 380                 


Thr Tyr Val Thr Gly Gly Glu Ala Gly Arg Arg Thr Ser Gly Phe Ala 
385                 390                 395                 400 


Ser Ile Phe Thr Pro Gly Ala Ser Gln Asn Ile Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu His Thr Gly Phe Ile Ala Ala Leu Phe Tyr His His Lys Phe Asn 
        435                 440                 445             


Ala Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Arg Pro Ile Gly Glu 
    450                 455                 460                 


Phe Ala Gln Gly Trp Gly Pro Ile Ser Tyr Thr Glu Pro Pro Ser Ser 
465                 470                 475                 480 


Asp Gln Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Ser Gln Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Ala Pro Thr Tyr Asn 
        515                 520                 525             


Trp Gly Asp Asn Asp Thr Asp Val Leu Leu Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Gln Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Gly Thr Gly Phe 
545                 550                 555                 560 


Thr Lys Thr Cys Gly Gly Pro Pro Cys Asn Ile Gly Gly Val Gly Asn 
                565                 570                 575     


Asn Thr Leu Thr Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Thr Lys Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys Ile 
        595                 600                 605             


Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Phe 
    610                 615                 620                 


Thr Ile Thr Lys Ile Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Thr Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Glu Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Glu Trp 
            660                 665                 670         


Gln Ile Met Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Ile Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Ile Gly Ser Ala Ala Val Ser Phe Ala Ile Arg Trp Glu Tyr Val Leu 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ala Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ala Gln Ala Glu Ala 
            740                 745     


<210>  23
<211>  746
<212>  PRT
<213>  Hepatitis C virus

<400>  23

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Gln Pro Glu Gly Arg Ala Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Met Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Ile Pro Ala Ser Ala Tyr 
            180                 185                 190         


Glu Val Arg Asn Val Ser Gly Met Tyr His Val Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Ala Asp Met Ile Leu His Ala Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Asn Asn Ser Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ala Leu Thr Pro Thr Leu Ala Ala Arg Asn Ala Ser Val Pro Thr Thr 
                245                 250                 255     


Ala Ile Arg Arg His Val Asp Leu Leu Val Gly Ala Ala Ala Phe Cys 
            260                 265                 270         


Ser Ala Met Tyr Val Gly Asp Leu Cys Gly Ser Val Leu Leu Val Ser 
        275                 280                 285             


Gln Ile Phe Thr Phe Ser Pro Arg Arg His Glu Thr Met Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ser Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Ile Val Asp Met Val Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Leu Ala Tyr Tyr Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Ile Val Met Leu Leu Phe Ala Gly Val Asp Gly Gly 
    370                 375                 380                 


Thr Tyr Val Thr Gly Gly Glu Ala Gly Arg Arg Thr Ser Gly Phe Ala 
385                 390                 395                 400 


Ser Ile Phe Thr Pro Gly Ala Ser Gln Asn Ile Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu His Thr Gly Phe Ile Ala Ala Leu Phe Tyr His His Lys Phe Asn 
        435                 440                 445             


Ala Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Arg Pro Ile Gly Glu 
    450                 455                 460                 


Phe Ala Gln Gly Trp Gly Pro Ile Ser Tyr Thr Glu Pro Pro Ser Ser 
465                 470                 475                 480 


Asp Gln Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Ser Gln Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Ala Pro Thr Tyr Asn 
        515                 520                 525             


Trp Gly Asp Asn Asp Thr Asp Val Leu Leu Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Gln Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Gly Thr Gly Phe 
545                 550                 555                 560 


Thr Lys Thr Cys Gly Gly Pro Pro Cys Asn Ile Gly Gly Val Gly Asn 
                565                 570                 575     


Asn Thr Leu Thr Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Thr Lys Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys Ile 
        595                 600                 605             


Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Phe 
    610                 615                 620                 


Thr Ile Thr Lys Ile Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Thr Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Glu Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Glu Trp 
            660                 665                 670         


Gln Ile Met Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Ile Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Ile Gly Ser Ala Ala Val Ser Phe Ala Ile Arg Trp Glu Tyr Val Leu 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ala Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ala Gln Ala Glu Ala 
            740                 745     


<210>  24
<211>  746
<212>  PRT
<213>  Hepatitis C virus

<400>  24

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Ala Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Thr Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Ile Pro Ala Ser Ala Tyr 
            180                 185                 190         


Glu Val Arg Asn Val Ser Gly Val Tyr His Val Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Thr Ala Asp Met Ile Met His Thr Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Asp Asn Phe Thr Arg Cys Trp Val 
225                 230                 235                 240 


Ala Leu Thr Pro Thr Leu Ala Ala Arg Asn Gly Ser Val Pro Thr Thr 
                245                 250                 255     


Ala Ile Arg Arg His Val Asp Leu Leu Val Gly Ala Ala Ala Phe Cys 
            260                 265                 270         


Ser Ala Met Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Ser 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Trp His Glu Thr Val Gln Glu Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Val Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ser Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Val Val Asp Met Val Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Leu Ala Tyr Tyr Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Ile Val Thr Leu Leu Phe Ala Gly Val Asp Gly Asn 
    370                 375                 380                 


Thr His Thr Ile Gly Gly Lys Gln Ala Gln Ala Thr Gly Gly Phe Val 
385                 390                 395                 400 


Ala Trp Leu Ala Arg Gly Pro Ser Gln Glu Ile Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Lys Thr Gly Phe Ile Ala Ala Leu Phe Tyr Ala His Arg Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Arg Pro Ile Asp Lys 
    450                 455                 460                 


Phe Ala Gln Gly Trp Gly Pro Ile Thr Tyr Ala Lys Pro Asp Ser Leu 
465                 470                 475                 480 


Asp Gln Arg Pro Tyr Cys Trp His Tyr Ala Pro Gln Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Ser Glu Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Arg Ser Gly Val Pro Thr Tyr Arg 
        515                 520                 525             


Trp Gly Glu Asn Glu Thr Asp Val Leu Leu Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Gln Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ala Thr Gly Phe 
545                 550                 555                 560 


Thr Lys Thr Cys Gly Gly Pro Pro Cys Lys Ile Gly Gly Leu Gly Asn 
                565                 570                 575     


Asn Thr Leu Thr Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Thr Lys Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys Ile 
        595                 600                 605             


Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Phe 
    610                 615                 620                 


Thr Ile Phe Lys Val Arg Met Tyr Val Gly Gly Ile Glu His Arg Leu 
625                 630                 635                 640 


Ser Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Glu Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Glu Trp 
            660                 665                 670         


Gln Ile Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Thr Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Val Gly Ser Val Leu Val Ser Phe Ala Ile Lys Trp Glu Tyr Ile Leu 
705                 710                 715                 720 


Leu Phe Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ala Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ala Gln Ala Glu Ala 
            740                 745     


<210>  25
<211>  746
<212>  PRT
<213>  Hepatitis C virus

<400>  25

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asn Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Cys Leu Leu Pro Arg Arg Gly Pro Arg Val Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Ser Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Arg Gly Pro Ser Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Val 
            180                 185                 190         


Glu Val Arg Asn Ser Ser Gly Ile Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ala Ser Val Val Tyr Glu Thr Asp Ser Leu Ile Ile His Leu Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ala Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ser Leu Ser Pro Thr Val Ala Ala Lys Asp Pro Gly Val Pro Val Asn 
                245                 250                 255     


Glu Ile Arg Arg His Val Asp Leu Ile Val Gly Ala Ala Ala Phe Cys 
            260                 265                 270         


Ser Ala Met Tyr Val Gly Asp Leu Cys Gly Ser Ile Phe Leu Val Gly 
        275                 280                 285             


Gln Leu Phe Thr Leu Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Val Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Gly Ala Leu Val Val Ala Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Val Leu Asp Met Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Pro Ala Tyr Tyr Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Thr 
    370                 375                 380                 


Thr Gln Val Thr Gly Gly Thr Ala Gly Arg Asn Ala Tyr Arg Leu Ala 
385                 390                 395                 400 


Ser Leu Phe Ser Thr Gly Pro Ser Gln Asn Ile Gln Leu Ile Asn Ser 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu His Thr Gly Trp Val Ala Ala Leu Phe Tyr Ser His Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Arg Pro Glu Arg Met Ala Ser Cys Arg Pro Leu Thr Ala 
    450                 455                 460                 


Phe Asp Gln Gly Trp Gly Pro Ile Thr Tyr Gly Gly Lys Ala Ser Asn 
465                 470                 475                 480 


Asp Gln Arg Pro Tyr Cys Trp His Tyr Ala Pro Arg Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Lys Glu Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Lys Tyr Gly Val Pro Thr Tyr Thr 
        515                 520                 525             


Trp Gly Glu Asn Glu Thr Asp Val Leu Leu Leu Asn Asn Ser Arg Pro 
    530                 535                 540                 


Pro Ile Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly Phe 
545                 550                 555                 560 


Thr Lys Thr Cys Gly Ala Pro Ala Cys Asn Val Gly Gly Ser Glu Thr 
                565                 570                 575     


Asn Thr Leu Ser Cys Pro Thr Asp Cys Phe Arg Arg His Pro Asp Ala 
            580                 585                 590         


Thr Tyr Ala Lys Cys Gly Ser Gly Pro Trp Leu Asn Pro Arg Cys Met 
        595                 600                 605             


Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Tyr 
    610                 615                 620                 


Thr Ile Phe Lys Ile Arg Met Phe Val Gly Gly Ile Glu His Arg Leu 
625                 630                 635                 640 


Thr Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Asp Asp 
                645                 650                 655     


Arg Asp Arg Ala Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Leu Ser Ser Val Val Thr Ser Trp Ala Ile Arg Trp Glu Tyr Val Val 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys Ala Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ser Gln Val Glu Ala 
            740                 745     


<210>  26
<211>  746
<212>  PRT
<213>  Hepatitis C virus

<400>  26

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Tyr 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Val 
            180                 185                 190         


Gly Val Arg Asn Ser Ser Gly Val Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ala Ser Val Val Tyr Glu Thr Asp Ser Leu Ile Ile His Leu Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Gly Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ser Leu Ser Pro Thr Val Ala Ala Lys Asp Pro Gly Val Pro Val Asn 
                245                 250                 255     


Glu Ile Arg Arg His Val Asp Leu Ile Ala Gly Ala Ala Ala Phe Cys 
            260                 265                 270         


Ser Ala Met Tyr Val Gly His Leu Cys Gly Ser Ile Phe Leu Val Gly 
        275                 280                 285             


Gln Leu Phe Thr Leu Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Val Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ala Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn Trp 
        355                 360                 365             


Thr Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Thr 
    370                 375                 380                 


Thr Ile Val Ser Gly Gly Ser Ala Gly Arg Ser Thr Ala Gly Leu Val 
385                 390                 395                 400 


Gly Leu Phe Ser Pro Gly Ala Arg Gln Asn Ile Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Thr 
            420                 425                 430         


Leu Gln Thr Gly Trp Val Ala Gly Leu Phe Tyr Thr Asn Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Leu Ala Ser Cys Arg Pro Leu Ala Asp 
    450                 455                 460                 


Phe Asp Gln Gly Trp Gly Pro Ile Ser Tyr Thr Asn Gly Ser Gly Pro 
465                 470                 475                 480 


Asp Gln Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Glu Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Arg Ser Gly Ala Pro Thr Tyr Asn 
        515                 520                 525             


Trp Gly Glu Asn Glu Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Arg Leu Gly Asn Trp Phe Gly Gly Thr Trp Met Asn Ser Thr Gly Phe 
545                 550                 555                 560 


Thr Lys Val Cys Gly Ala Pro Pro Cys Ala Ile Gly Gly Val Gly Asn 
                565                 570                 575     


Asn Thr Leu Tyr Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Leu 
        595                 600                 605             


Ile His Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Ile Asn Tyr 
    610                 615                 620                 


Thr Ile Phe Lys Ile Arg Met Phe Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Asp Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Asp Asp 
                645                 650                 655     


Arg Asp Arg Ala Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Leu Ser Ser Ala Val Thr Ser Trp Val Ile Lys Trp Glu Tyr Val Val 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys Ala Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ser Gln Val Glu Ala 
            740                 745     


<210>  27
<211>  746
<212>  PRT
<213>  Hepatitis C virus

<400>  27

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Val Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Ser Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Ser Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Val 
            180                 185                 190         


Gly Val Arg Asn Ser Ser Gly Val Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ala Ser Val Val Tyr Glu Thr Glu Asn Leu Ile Met His Leu Pro 
    210                 215                 220                 


Gly Cys Val Pro Tyr Val Arg Glu Gly Asn Ala Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ser Leu Ser Pro Thr Val Ala Ala Arg Asp Ser Arg Val Pro Val Ser 
                245                 250                 255     


Glu Val Arg Arg Arg Val Asp Ser Ile Val Gly Ala Ala Ala Phe Cys 
            260                 265                 270         


Ser Ala Met Tyr Val Gly Asp Leu Cys Gly Ser Ile Phe Leu Val Gly 
        275                 280                 285             


Gln Ile Phe Thr Phe Ser Pro Arg His His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Val Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Gly Ala Leu Val Val Ala Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Ile Val Asp Met Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Leu Ala Tyr Tyr Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Val Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Glu 
    370                 375                 380                 


Thr Arg Val Thr Gly Gly Ala Ala Gly His Thr Ala Phe Gly Phe Ala 
385                 390                 395                 400 


Ser Phe Leu Ala Pro Gly Ala Lys Gln Lys Ile Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Glu Ser 
            420                 425                 430         


Leu Asp Thr Gly Trp Leu Ala Gly Leu Leu Tyr Tyr His Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Gln Pro Leu Thr Ala 
    450                 455                 460                 


Phe Asp Gln Gly Trp Gly Pro Ile Thr His Glu Gly Asn Ala Ser Asp 
465                 470                 475                 480 


Asp Gln Arg Pro Tyr Cys Trp His Tyr Ala Leu Arg Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Lys Lys Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Arg Ala Gly Val Pro Thr Tyr Arg 
        515                 520                 525             


Trp Gly Ala Asn Glu Thr Asp Val Leu Leu Leu Asn Asn Ser Arg Pro 
    530                 535                 540                 


Pro Met Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Ser Gly Phe 
545                 550                 555                 560 


Thr Lys Thr Cys Gly Ala Pro Ala Cys Asn Ile Gly Gly Ser Gly Asn 
                565                 570                 575     


Asn Thr Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys His Pro Asp Ala 
            580                 585                 590         


Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys Leu 
        595                 600                 605             


Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn Tyr 
    610                 615                 620                 


Thr Ile Phe Lys Ile Arg Met Phe Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Asp Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Asp Asp 
                645                 650                 655     


Arg Asp Arg Ala Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Leu Ser Ser Ala Val Thr Ser Trp Val Ile Lys Trp Glu Tyr Val Val 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys Ala Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ser Gln Val Glu Ala 
            740                 745     


<210>  28
<211>  752
<212>  PRT
<213>  Hepatitis C virus

<400>  28

Met Ser Thr Leu Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Ile 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Val Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Ser Glu Gly Arg Ser Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Ala Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Phe Ser Cys Leu Ile His Pro Ala Ala Ser Leu 
            180                 185                 190         


Glu Trp Arg Asn Thr Ser Gly Leu Tyr Val Leu Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Asp Asp Val Ile Leu His Thr Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Gln Asp Gly Asn Thr Ser Thr Cys Trp Thr 
225                 230                 235                 240 


Pro Val Thr Pro Thr Val Ala Val Arg Tyr Val Gly Ala Thr Thr Ala 
                245                 250                 255     


Ser Ile Arg Ser His Val Asp Leu Leu Val Gly Ala Ala Thr Met Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Met Cys Gly Ala Val Phe Leu Val Gly 
        275                 280                 285             


Gln Ala Phe Thr Phe Arg Pro Arg Arg His Gln Thr Val Gln Thr Cys 
    290                 295                 300                 


Asn Cys Ser Leu Tyr Pro Gly His Leu Ser Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Ala Val Gly Met Val Val Ala His 
                325                 330                 335     


Val Leu Arg Leu Pro Gln Thr Leu Phe Asp Ile Met Ala Gly Ala His 
            340                 345                 350         


Trp Gly Ile Leu Ala Gly Leu Ala Tyr Tyr Ser Met Gln Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Ala Ile Ile Met Val Met Phe Ser Gly Val Asp Ala His 
    370                 375                 380                 


Thr Tyr Thr Thr Gly Gly Thr Ala Ser Arg His Thr Gln Ala Phe Ala 
385                 390                 395                 400 


Gly Leu Phe Asp Ile Gly Pro Gln Gln Lys Leu Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Ser Thr Ala Leu Asn Cys Asn Glu Ser 
            420                 425                 430         


Ile Asn Thr Gly Phe Ile Ala Gly Leu Phe Tyr Tyr His Lys Phe Asn 
        435                 440                 445             


Ser Thr Gly Cys Pro Gln Arg Leu Ser Ser Cys Lys Pro Ile Thr Phe 
    450                 455                 460                 


Phe Arg Gln Gly Trp Gly Pro Leu Thr Asp Ala Asn Ile Thr Gly Pro 
465                 470                 475                 480 


Ser Asp Asp Arg Pro Tyr Cys Trp His Tyr Ala Pro Arg Pro Cys Asp 
                485                 490                 495     


Ile Val Pro Ala Ser Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro 
            500                 505                 510         


Ser Pro Val Val Val Gly Thr Thr Asp Ala Arg Gly Val Pro Thr Tyr 
        515                 520                 525             


Thr Trp Gly Glu Asn Glu Lys Asp Val Phe Leu Leu Lys Ser Gln Arg 
    530                 535                 540                 


Pro Pro Ser Gly Arg Trp Phe Gly Cys Ser Trp Met Asn Ser Thr Gly 
545                 550                 555                 560 


Phe Leu Lys Thr Cys Gly Ala Pro Pro Cys Asn Ile Tyr Gly Gly Glu 
                565                 570                 575     


Gly Asn Pro His Asn Glu Ser Asp Leu Phe Cys Pro Thr Asp Cys Phe 
            580                 585                 590         


Arg Lys His Pro Glu Thr Thr Tyr Ser Arg Cys Gly Ala Gly Pro Trp 
        595                 600                 605             


Leu Thr Pro Arg Cys Met Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr 
    610                 615                 620                 


Pro Cys Thr Val Asp Phe Arg Leu Phe Lys Val Arg Met Phe Val Gly 
625                 630                 635                 640 


Gly Phe Glu His Arg Phe Thr Ala Ala Cys Asn Trp Thr Arg Gly Glu 
                645                 650                 655     


Arg Cys Asp Ile Glu Asp Arg Asp Arg Ser Glu Gln His Pro Leu Leu 
            660                 665                 670         


His Ser Thr Thr Glu Leu Ala Ile Leu Pro Cys Ser Phe Thr Pro Met 
        675                 680                 685             


Pro Ala Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp 
    690                 695                 700                 


Val Gln Tyr Leu Tyr Gly Val Gly Ser Gly Met Val Gly Trp Ala Leu 
705                 710                 715                 720 


Lys Trp Glu Phe Val Ile Leu Val Phe Leu Leu Leu Ala Asp Ala Arg 
                725                 730                 735     


Val Cys Val Ala Leu Trp Leu Met Leu Met Ile Ser Gln Thr Glu Ala 
            740                 745                 750         


<210>  29
<211>  752
<212>  PRT
<213>  Hepatitis C virus

<400>  29

Met Ser Thr Leu Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Ile 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Val Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Ser Glu Gly Arg Ser Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Gln Asn Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Ala Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Phe Ser Cys Leu Ile His Pro Ala Ala Ser Leu 
            180                 185                 190         


Glu Trp Arg Asn Thr Ser Gly Leu Tyr Val Leu Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Asp Asp Val Ile Leu His Thr Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Gln Asp Gly Asn Thr Ser Thr Cys Trp Thr 
225                 230                 235                 240 


Pro Val Thr Pro Thr Val Ala Val Arg Tyr Val Gly Ala Thr Thr Ala 
                245                 250                 255     


Ser Ile Arg Ser His Val Asp Leu Leu Val Gly Ala Ala Thr Met Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Met Cys Gly Ala Val Phe Leu Val Gly 
        275                 280                 285             


Gln Ala Phe Thr Phe Arg Pro Arg Arg His Gln Thr Val Gln Thr Cys 
    290                 295                 300                 


Asn Cys Ser Leu Tyr Pro Gly His Leu Ser Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Ala Val Gly Met Val Val Ser His 
                325                 330                 335     


Val Leu Arg Leu Pro Gln Thr Leu Phe Asp Ile Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Ile Leu Ala Gly Leu Ala Tyr Tyr Ser Met Gln Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Ala Val Ile Met Val Met Phe Ser Gly Val Asp Ala Glu 
    370                 375                 380                 


Thr Tyr Ile Thr Gly Gly Ser Ala Ala His Gly Val Ser Thr Leu Thr 
385                 390                 395                 400 


Ser Leu Phe Ser Ser Gly Pro Gln Gln Lys Leu Gln Leu Val Lys Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Ser Thr Ala Leu Asn Cys Asn Glu Ser 
            420                 425                 430         


Ile Asn Thr Gly Phe Ile Ala Gly Leu Phe Tyr Tyr His Lys Phe Asn 
        435                 440                 445             


Ser Thr Gly Cys Pro Gln Arg Leu Ser Ser Cys Lys Pro Ile Thr Phe 
    450                 455                 460                 


Phe Arg Gln Gly Trp Gly Ser Leu Thr Asp Ala Asn Val Thr Gly Ala 
465                 470                 475                 480 


Ser Ala Asp Lys Pro Tyr Cys Trp His Tyr Ala Pro Arg Pro Cys Asp 
                485                 490                 495     


Val Val Pro Ala Leu Asn Val Cys Gly Pro Val Tyr Cys Phe Thr Pro 
            500                 505                 510         


Ser Pro Val Val Val Gly Thr Thr Asp Arg Lys Gly Val Pro Thr Tyr 
        515                 520                 525             


Asn Trp Gly Glu Asn Glu Ser Asp Val Phe Leu Leu Glu Ser Leu Arg 
    530                 535                 540                 


Pro Pro Ser Gly Arg Trp Phe Gly Cys Ala Trp Met Asn Ser Thr Gly 
545                 550                 555                 560 


Phe Leu Lys Thr Cys Gly Ala Pro Pro Cys Asn Ile Tyr Gly Gly Gly 
                565                 570                 575     


Gly Asn Pro Asn Asn Glu Ser His Leu Phe Cys Pro Thr Asp Cys Phe 
            580                 585                 590         


Arg Lys His Pro Asp Ala Thr Tyr Ser Arg Cys Gly Ala Gly Pro Trp 
        595                 600                 605             


Leu Thr Pro Arg Cys Met Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr 
    610                 615                 620                 


Pro Cys Thr Val Asn Phe Thr Leu Phe Lys Val Arg Met Phe Val Gly 
625                 630                 635                 640 


Gly Phe Glu His Arg Phe Thr Ala Ala Cys Asn Trp Thr Arg Gly Glu 
                645                 650                 655     


Arg Cys Asn Ile Glu Asp Arg Asp Arg Ser Glu Gln His Pro Leu Leu 
            660                 665                 670         


His Ser Thr Thr Glu Leu Ala Ile Leu Pro Cys Ser Phe Thr Pro Met 
        675                 680                 685             


Pro Ala Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp 
    690                 695                 700                 


Val Gln Tyr Leu Tyr Gly Val Gly Ser Gly Met Val Gly Trp Ala Leu 
705                 710                 715                 720 


Lys Trp Glu Phe Val Ile Leu Ile Phe Leu Leu Leu Ala Asp Ala Arg 
                725                 730                 735     


Val Cys Val Ala Leu Trp Leu Met Leu Met Ile Ser Gln Ala Glu Ala 
            740                 745                 750         


<210>  30
<211>  752
<212>  PRT
<213>  Hepatitis C virus

<400>  30

Met Ser Thr Leu Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Ile 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Val Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Cys Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Arg Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Gln Ser Gly Gly Arg Ser Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Ala Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Phe Ser Cys Leu Ile His Pro Ala Ala Ser Leu 
            180                 185                 190         


Glu Trp Arg Asn Thr Ser Gly Leu Tyr Val Leu Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Asp Asp Val Ile Leu His Thr Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Gln Asn Asp Asn Ile Ser Thr Cys Trp Thr 
225                 230                 235                 240 


Pro Val Thr Pro Thr Val Ala Val Arg Tyr Val Gly Ala Thr Thr Ala 
                245                 250                 255     


Ser Ile Arg Ser His Val Asp Leu Leu Val Gly Ala Ala Thr Met Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Met Cys Gly Ala Val Phe Leu Val Gly 
        275                 280                 285             


Gln Ala Phe Thr Phe Arg Pro Arg Arg His Gln Thr Val Gln Thr Cys 
    290                 295                 300                 


Asn Cys Ser Leu Tyr Pro Gly His Leu Ser Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Phe Pro Ala Leu Gly Met Ala Val Ala His 
                325                 330                 335     


Val Leu Arg Val Pro Gln Thr Leu Phe Asp Ile Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Ile Leu Ala Gly Leu Ala Tyr Tyr Ser Met Gln Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Ala Ile Ile Met Val Met Phe Ser Gly Val Asp Ala Val 
    370                 375                 380                 


Thr Tyr Thr Thr Gly Gly Ser Ala Ala His Ala Thr Arg Gly Leu Thr 
385                 390                 395                 400 


Ser Leu Phe Ser Val Gly Ala Gln Gln Lys Leu Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Ser Thr Ala Leu Asn Cys Asn Glu Ser 
            420                 425                 430         


Ile Asn Thr Gly Phe Ile Ala Gly Leu Phe Tyr Tyr His Arg Phe Asn 
        435                 440                 445             


Ser Thr Gly Cys Pro Gln Arg Leu Ser Ser Cys Lys Pro Ile Thr Phe 
    450                 455                 460                 


Phe Lys Gln Gly Trp Gly Pro Leu Thr Asp Ala Asn Ile Ser Gly Pro 
465                 470                 475                 480 


Ser Asp Asp Lys Pro Tyr Cys Trp His Tyr Ala Pro Arg Pro Cys Lys 
                485                 490                 495     


Val Val Pro Ala Ser Gly Val Cys Gly Pro Val Tyr Cys Phe Thr Pro 
            500                 505                 510         


Ser Pro Val Val Val Gly Thr Thr Asp Ala Lys Gly Val Pro Thr Tyr 
        515                 520                 525             


Thr Trp Gly Ala Asn Asp Thr Asp Val Phe Leu Leu Glu Ser Leu Arg 
    530                 535                 540                 


Pro Pro Gly Gly Arg Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly 
545                 550                 555                 560 


Phe Val Lys Thr Cys Gly Ala Ser Pro Cys Asp Ile Tyr Gly Gly Gly 
                565                 570                 575     


Gly Asn Ser Gly Asn Glu Ser Asp Leu Phe Cys Pro Thr Asp Cys Phe 
            580                 585                 590         


Arg Lys His Pro Glu Ala Thr Tyr Ser Arg Cys Gly Ala Gly Pro Trp 
        595                 600                 605             


Leu Thr Pro Arg Cys Met Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr 
    610                 615                 620                 


Pro Cys Thr Val Asn Phe Thr Leu Phe Lys Val Arg Met Phe Val Gly 
625                 630                 635                 640 


Gly Phe Glu His Arg Phe Thr Ala Ala Cys Asn Trp Thr Arg Gly Glu 
                645                 650                 655     


Arg Cys Asp Ile Glu Asp Arg Asp Arg Ser Glu Gln His Pro Leu Leu 
            660                 665                 670         


His Ser Thr Thr Glu Leu Ala Ile Leu Pro Cys Ser Phe Thr Pro Met 
        675                 680                 685             


Pro Ala Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp 
    690                 695                 700                 


Val Gln Tyr Leu Tyr Gly Val Gly Ser Gly Met Val Gly Trp Ala Leu 
705                 710                 715                 720 


Lys Trp Glu Phe Val Ile Leu Ile Phe Leu Leu Leu Ala Asp Arg Arg 
                725                 730                 735     


Val Cys Val Ala Leu Trp Leu Met Leu Met Ile Thr Gln Ala Glu Ala 
            740                 745                 750         


<210>  31
<211>  752
<212>  PRT
<213>  Hepatitis C virus

<400>  31

Met Ser Thr Leu Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Val 
1               5                   10                  15      


Cys Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Val Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Ser Glu Gly Arg Ser Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Ala Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Phe Ser Cys Leu Ile His Pro Ala Ala Ser Leu 
            180                 185                 190         


Glu Trp Arg Asn Val Ser Gly Leu Tyr Ile Leu Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Asp Asp Val Ile Leu His Thr Pro 
    210                 215                 220                 


Gly Cys Ile Pro Cys Val Gln Asp Gly Asn Thr Ser Thr Cys Trp Thr 
225                 230                 235                 240 


Ala Leu Thr Pro Thr Val Ala Val Arg Tyr Val Gly Ala Thr Thr Ala 
                245                 250                 255     


Ser Ile Arg Ser His Val Asp Leu Leu Val Gly Ala Ala Thr Met Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Met Cys Gly Ala Val Phe Leu Val Gly 
        275                 280                 285             


Gln Ala Phe Thr Phe Arg Pro Arg Arg His Gln Thr Val Gln Thr Cys 
    290                 295                 300                 


Asn Cys Ser Leu Tyr Pro Gly His Leu Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Ala Val Gly Met Val Val Ala His 
                325                 330                 335     


Val Leu Arg Leu Pro Gln Thr Leu Phe Asp Ile Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Ile Leu Ala Gly Leu Ala Tyr Tyr Ser Met Gln Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Ile Ile Ile Met Val Met Phe Ser Gly Val Asp Ala Thr 
    370                 375                 380                 


Thr His Val Thr Gly Gly Thr Ala Gly Leu Thr Ala Phe Arg Leu Thr 
385                 390                 395                 400 


Gly Leu Phe Thr Val Gly Pro Gln Gln Lys Leu Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Asn Thr Gly Phe Ile Ala Gly Leu Phe Arg Phe His Lys Phe Asn 
        435                 440                 445             


Ser Thr Gly Cys Pro Glu Met Leu Ser Ser Cys Lys Pro Ile Thr Ser 
    450                 455                 460                 


Phe Lys Gln Gly Trp Gly Pro Leu Thr Asp Ala Asn Ile Thr Ile Pro 
465                 470                 475                 480 


Ser Asp Asp Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Ser Cys Glu 
                485                 490                 495     


Val Val Pro Ala Leu Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro 
            500                 505                 510         


Ser Pro Val Val Val Gly Thr Thr Asp Ala Lys Gly Val Pro Thr Tyr 
        515                 520                 525             


Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Lys Ser Leu Arg 
    530                 535                 540                 


Pro Pro Gly Gly Arg Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly 
545                 550                 555                 560 


Phe Val Gln Thr Cys Gly Ala Pro Pro Cys Asn Ile Tyr Gly Gly Gly 
                565                 570                 575     


Gly Asp Leu Lys Asn Glu Ser Asp Leu Phe Cys Pro Thr Asp Cys Phe 
            580                 585                 590         


Arg Lys His Pro Glu Ala Thr Tyr Ser Arg Cys Gly Ala Gly Pro Trp 
        595                 600                 605             


Leu Thr Pro Arg Cys Met Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr 
    610                 615                 620                 


Pro Cys Thr Val Asn Phe Thr Leu Phe Lys Val Arg Met Phe Val Gly 
625                 630                 635                 640 


Gly Phe Glu His Arg Phe Thr Ala Ala Cys Asn Trp Thr Arg Gly Glu 
                645                 650                 655     


Arg Cys Asp Ile Glu Asp Arg Asp Arg Ser Glu Leu His Pro Leu Leu 
            660                 665                 670         


His Ser Thr Thr Glu Leu Ala Ile Leu Pro Cys Ser Phe Thr Pro Met 
        675                 680                 685             


Pro Ala Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp 
    690                 695                 700                 


Val Gln Tyr Leu Tyr Gly Val Gly Ser Gly Met Val Gly Trp Ala Val 
705                 710                 715                 720 


Lys Trp Glu Phe Val Ile Leu Val Phe Leu Leu Leu Ala Asp Ala Arg 
                725                 730                 735     


Val Cys Val Ala Leu Trp Leu Met Leu Met Ile Ser Gln Ala Glu Ala 
            740                 745                 750         


<210>  32
<211>  752
<212>  PRT
<213>  Hepatitis C virus

<400>  32

Met Ser Thr Leu Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Ile 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Val Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Ser Glu Gly Arg Ser Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Ala Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Phe Ser Cys Leu Ile His Pro Ala Ala Ser Leu 
            180                 185                 190         


Gln Trp Arg Asn Thr Ser Gly Leu Tyr Val Leu Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Asp Asp Val Ile Leu His Thr Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Gln Asp Gly Asn Thr Ser Thr Cys Trp Thr 
225                 230                 235                 240 


Pro Val Thr Pro Thr Val Ala Val Arg Tyr Val Gly Ala Thr Thr Ala 
                245                 250                 255     


Ser Ile Arg Ser His Val Asp Leu Leu Val Gly Ala Ala Thr Met Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Met Cys Gly Ala Val Phe Leu Val Gly 
        275                 280                 285             


Gln Ala Phe Thr Phe Arg Pro Arg Arg His Gln Thr Val Gln Thr Cys 
    290                 295                 300                 


Asn Cys Ser Leu Tyr Pro Gly His Leu Ser Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Ala Ala Gly Met Val Val Ala His 
                325                 330                 335     


Ile Leu Arg Leu Pro Gln Thr Leu Phe Asp Ile Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Ile Leu Ala Gly Leu Ala Tyr Tyr Ser Met Gln Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Ala Ile Ile Met Val Met Phe Ser Gly Val Asp Ala Thr 
    370                 375                 380                 


Thr Tyr Thr Ser Gly Gly Ser Val Ala Gln Gln Ala Arg Gly Leu Ala 
385                 390                 395                 400 


Asp Leu Phe Ser Val Gly Ala Lys Gln Asn Leu Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Ser Thr Ala Leu Asn Cys Asp Asp Ser 
            420                 425                 430         


Ile Asn Thr Gly Phe Ile Ala Gly Leu Phe Tyr Tyr His Lys Phe Asn 
        435                 440                 445             


Ser Thr Gly Cys Pro Gln Arg Leu Ser Asp Cys Lys Pro Ile Thr Phe 
    450                 455                 460                 


Phe Lys Gln Gly Trp Gly Pro Leu Thr Asp Ala Asn Ile Thr Gly Pro 
465                 470                 475                 480 


Ser Asp Asp Lys Pro Tyr Cys Trp His Tyr Ala Pro Arg Arg Cys Gly 
                485                 490                 495     


Val Val Pro Ala Ser Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro 
            500                 505                 510         


Ser Pro Val Val Val Gly Thr Thr Asp Ala Lys Gly Val Pro Thr Tyr 
        515                 520                 525             


Thr Trp Gly Ala Asn Glu Thr Asp Val Phe Leu Leu Glu Ser Leu Arg 
    530                 535                 540                 


Pro Pro Ser Gly Arg Trp Phe Gly Cys Ala Trp Met Asn Ser Thr Gly 
545                 550                 555                 560 


Phe Leu Lys Thr Cys Gly Ala Pro Pro Cys Asn Ile Tyr Gly Gly Gly 
                565                 570                 575     


Gly Asn Pro His Asn Glu Ser Asp Leu Phe Cys Pro Thr Asp Cys Phe 
            580                 585                 590         


Arg Lys His Pro Glu Ala Thr Tyr Ser Arg Cys Gly Ala Gly Pro Trp 
        595                 600                 605             


Leu Thr Pro Arg Cys Met Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr 
    610                 615                 620                 


Pro Cys Thr Val Asn Phe Thr Leu Phe Lys Met Arg Thr Phe Val Gly 
625                 630                 635                 640 


Gly Phe Glu His Arg Phe Thr Ala Ala Cys Asn Trp Thr Arg Gly Glu 
                645                 650                 655     


Arg Cys Asp Ile Glu Asp Arg Asp Arg Ser Glu Gln His Pro Leu Leu 
            660                 665                 670         


His Ser Thr Thr Glu Leu Ala Ile Leu Pro Cys Ser Phe Thr Pro Met 
        675                 680                 685             


Pro Ala Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp 
    690                 695                 700                 


Val Gln Tyr Leu Tyr Gly Val Gly Ser Gly Met Val Gly Trp Ala Leu 
705                 710                 715                 720 


Lys Trp Glu Phe Val Ile Leu Val Phe Leu Leu Leu Ala Asp Ala Arg 
                725                 730                 735     


Val Cys Val Ala Leu Trp Leu Met Leu Met Ile Ser Gln Ala Glu Ala 
            740                 745                 750         


<210>  33
<211>  752
<212>  PRT
<213>  Hepatitis C virus

<400>  33

Met Ser Thr Leu Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Ile 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Val Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Ser Glu Gly Arg Ser Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Ala Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Phe Ser Cys Leu Ile His Pro Ala Ala Ser Leu 
            180                 185                 190         


Gln Trp Arg Asn Thr Ser Gly Leu Tyr Val Leu Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Asp Asp Val Ile Leu His Thr Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Gln Asp Gly Asn Thr Ser Thr Cys Trp Thr 
225                 230                 235                 240 


Pro Val Thr Pro Thr Val Ala Val Arg Tyr Val Gly Ala Thr Thr Ala 
                245                 250                 255     


Ser Ile Arg Ser His Val Asp Leu Leu Val Gly Ala Ala Thr Met Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Met Cys Gly Ala Val Phe Leu Val Gly 
        275                 280                 285             


Gln Ala Phe Thr Phe Arg Pro Arg Arg His Gln Thr Val Gln Thr Cys 
    290                 295                 300                 


Asn Cys Ser Leu Tyr Pro Gly His Leu Ser Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Ala Ala Gly Met Val Val Ala His 
                325                 330                 335     


Ile Leu Arg Leu Pro Gln Thr Leu Phe Asp Ile Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Ile Leu Ala Gly Leu Ala Tyr Tyr Ser Met Gln Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Ala Ile Ile Met Val Met Phe Ser Gly Val Asp Ala Thr 
    370                 375                 380                 


Thr Tyr Thr Ser Gly Gly Ser Val Ala Gln Gln Ala Arg Gly Leu Ala 
385                 390                 395                 400 


Asp Leu Phe Ser Val Gly Ala Lys Gln Asn Leu Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Ser Thr Ala Leu Asn Cys Asp Asp Ser 
            420                 425                 430         


Ile Asn Thr Gly Phe Ile Ala Gly Leu Phe Tyr Tyr His Lys Phe Asn 
        435                 440                 445             


Ser Thr Gly Cys Pro Gln Arg Leu Ser Asp Cys Lys Pro Ile Thr Phe 
    450                 455                 460                 


Phe Lys Gln Gly Trp Gly Pro Leu Thr Asp Ala Asn Ile Thr Gly Pro 
465                 470                 475                 480 


Ser Asp Asp Lys Pro Tyr Cys Trp His Tyr Ala Pro Arg Arg Cys Gly 
                485                 490                 495     


Val Val Pro Ala Ser Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro 
            500                 505                 510         


Ser Pro Val Val Val Gly Thr Thr Asp Ala Lys Gly Val Pro Thr Tyr 
        515                 520                 525             


Thr Trp Gly Ala Asn Glu Thr Asp Val Phe Leu Leu Glu Ser Leu Arg 
    530                 535                 540                 


Pro Pro Ser Gly Arg Trp Phe Gly Cys Ala Trp Met Asn Ser Thr Gly 
545                 550                 555                 560 


Phe Leu Lys Thr Cys Gly Ala Pro Pro Cys Asn Ile Tyr Gly Gly Gly 
                565                 570                 575     


Gly Asn Pro His Asn Glu Ser Asp Leu Phe Cys Pro Thr Asp Cys Phe 
            580                 585                 590         


Arg Lys His Pro Glu Ala Thr Tyr Ser Arg Cys Gly Ala Gly Pro Trp 
        595                 600                 605             


Leu Thr Pro Arg Cys Met Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr 
    610                 615                 620                 


Pro Cys Thr Val Asn Phe Thr Leu Phe Lys Met Arg Thr Phe Val Gly 
625                 630                 635                 640 


Gly Phe Glu His Arg Phe Thr Ala Ala Cys Asn Trp Thr Arg Gly Glu 
                645                 650                 655     


Arg Cys Asp Ile Glu Asp Arg Asp Arg Ser Glu Gln His Pro Leu Leu 
            660                 665                 670         


His Ser Thr Thr Glu Leu Ala Ile Leu Pro Cys Ser Phe Thr Pro Met 
        675                 680                 685             


Pro Ala Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp 
    690                 695                 700                 


Val Gln Tyr Leu Tyr Gly Val Gly Ser Gly Met Val Gly Trp Ala Leu 
705                 710                 715                 720 


Lys Trp Glu Phe Val Ile Leu Val Phe Leu Leu Leu Ala Asp Ala Arg 
                725                 730                 735     


Val Cys Val Ala Leu Trp Leu Met Leu Met Ile Ser Gln Ala Glu Ala 
            740                 745                 750         


<210>  34
<211>  752
<212>  PRT
<213>  Hepatitis C virus

<400>  34

Met Ser Thr Leu Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Ile 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Val Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Cys Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Ser Glu Gly Arg Ser Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Ala Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Phe Ser Cys Leu Val His Pro Ala Ala Ser Leu 
            180                 185                 190         


Glu Trp Arg Asn Thr Ser Gly Leu Tyr Val Leu Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Asp Asp Val Ile Leu His Thr Pro 
    210                 215                 220                 


Gly Cys Ile Pro Cys Val Gln Asp Gly Asn Lys Ser Thr Cys Trp Thr 
225                 230                 235                 240 


Ser Val Thr Pro Thr Val Ala Val Lys Tyr Val Gly Ala Thr Thr Ala 
                245                 250                 255     


Ser Ile Arg Ser His Val Asp Leu Leu Val Gly Ala Ala Thr Met Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Met Cys Gly Ala Val Phe Leu Val Gly 
        275                 280                 285             


Gln Ala Phe Thr Phe Arg Pro Arg Arg His Gln Thr Val Gln Thr Cys 
    290                 295                 300                 


Asn Cys Ser Leu Tyr Pro Gly His Leu Ser Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Ala Val Gly Met Val Val Ala His 
                325                 330                 335     


Val Leu Arg Leu Pro Gln Thr Leu Phe Asp Ile Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Ile Leu Ala Gly Leu Ala Tyr Tyr Ser Met Gln Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Ala Ile Ile Met Val Met Phe Ser Gly Val Asp Ala Thr 
    370                 375                 380                 


Thr Tyr Thr Thr Gly Gly Asn Ala Ala Arg Gly Ala Ser Gly Ile Val 
385                 390                 395                 400 


Ser Leu Phe Thr Pro Gly Ala Lys Gln Asn Leu Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Ile Asn Thr Gly Phe Ile Ala Gly Leu Ile Tyr Tyr His Lys Phe Asn 
        435                 440                 445             


Ser Thr Gly Cys Pro Gln Arg Leu Ser Ser Cys Lys Pro Ile Thr Phe 
    450                 455                 460                 


Phe Arg Gln Gly Trp Gly Ser Leu Thr Asp Ala Asn Ile Thr Gly Pro 
465                 470                 475                 480 


Ser Asp Asp Lys Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys Asp 
                485                 490                 495     


Thr Ile Arg Ala Ser Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro 
            500                 505                 510         


Ser Pro Val Val Val Gly Thr Thr Asp Ala Lys Gly Ala Pro Thr Tyr 
        515                 520                 525             


Asn Trp Gly Ala Asn Glu Thr Asp Met Phe Leu Leu Gln Ser Leu Arg 
    530                 535                 540                 


Pro Pro Ser Gly Arg Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly 
545                 550                 555                 560 


Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Asn Ile Tyr Gly Gly Gly 
                565                 570                 575     


Gly Asn Leu Asn Asn Glu Ser Asp Leu Phe Cys Pro Thr Asp Cys Phe 
            580                 585                 590         


Arg Lys His Pro Glu Ala Thr Tyr Ser Arg Cys Gly Ala Gly Pro Trp 
        595                 600                 605             


Leu Thr Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr 
    610                 615                 620                 


Pro Cys Thr Val Asn Phe Thr Leu Phe Arg Met Arg Thr Phe Val Gly 
625                 630                 635                 640 


Gly Phe Glu His Arg Phe Thr Ala Ala Cys Asn Trp Thr Arg Gly Glu 
                645                 650                 655     


Arg Cys Asn Ile Glu Asp Arg Asp Arg Ser Glu Gln His Pro Leu Leu 
            660                 665                 670         


His Ser Thr Thr Glu Leu Ala Ile Leu Pro Cys Ser Phe Thr Pro Met 
        675                 680                 685             


Pro Ala Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp 
    690                 695                 700                 


Val Gln Tyr Leu Tyr Gly Ile Gly Ser Gly Val Val Gly Trp Ala Leu 
705                 710                 715                 720 


Lys Trp Glu Phe Val Ile Leu Val Phe Leu Leu Leu Ala Asp Ala Arg 
                725                 730                 735     


Val Cys Val Ala Leu Trp Leu Met Leu Met Ile Ser Gln Ala Glu Ala 
            740                 745                 750         


<210>  35
<211>  752
<212>  PRT
<213>  Hepatitis C virus

<400>  35

Met Ser Thr Leu Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Ile 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Val Ile Tyr Val 
            20                  25                  30          


Gly Val Tyr Val Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Lys Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Ser Glu Gly Arg Ser Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Asn Trp Ala Pro Asn Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Ala Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Phe Ser Cys Leu Ile His Pro Ala Ala Ser Leu 
            180                 185                 190         


Glu Trp Arg Asn Thr Ser Gly Leu Tyr Val Leu Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Asp Asp Val Ile Leu His Thr Pro 
    210                 215                 220                 


Gly Cys Ile Pro Cys Val Gln Asp Gly Asn Thr Ser Thr Cys Trp Thr 
225                 230                 235                 240 


Pro Val Thr Pro Thr Val Ala Val Arg Tyr Val Gly Ala Thr Thr Ala 
                245                 250                 255     


Ser Ile Arg Ser His Val Asp Leu Leu Val Gly Ala Gly Thr Met Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Met Cys Gly Pro Val Phe Leu Val Gly 
        275                 280                 285             


Gln Ala Phe Thr Phe Arg Pro Arg Arg His Arg Thr Val Gln Thr Cys 
    290                 295                 300                 


Asn Cys Ser Leu Tyr Pro Gly His Leu Ser Gly Gln Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Ala Val Gly Met Val Val Ala His 
                325                 330                 335     


Ile Leu Arg Leu Pro Gln Thr Leu Phe Asp Val Val Ala Gly Ala His 
            340                 345                 350         


Trp Gly Ile Ile Ala Gly Leu Ala Tyr Tyr Ser Met Gln Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Ala Ile Ile Met Val Met Phe Ser Gly Val Asp Ala Ser 
    370                 375                 380                 


Thr His Val Thr Ala Gly Gln Ala Ala Arg Asn Ala Tyr Gly Ile Thr 
385                 390                 395                 400 


Ser Leu Phe Ser Val Gly Ala Lys Gln Asn Leu Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Glu Ser 
            420                 425                 430         


Ile Asn Thr Gly Phe Ile Ala Gly Leu Phe Tyr Tyr His Lys Phe Asn 
        435                 440                 445             


Ser Thr Gly Cys Pro Gln Arg Leu Ser Ser Cys Lys Pro Ile Thr Phe 
    450                 455                 460                 


Phe Lys Gln Gly Trp Gly Pro Leu Thr Asp Ala Asn Ile Thr Gly Pro 
465                 470                 475                 480 


Ser Asp Asp Lys Pro Tyr Cys Trp His Tyr Ala Pro Arg Pro Cys Gly 
                485                 490                 495     


Ile Val Pro Ala Leu Asn Val Cys Gly Pro Val Tyr Cys Phe Thr Pro 
            500                 505                 510         


Ser Pro Val Val Val Gly Thr Thr Asp Ala Lys Gly Ala Pro Thr Tyr 
        515                 520                 525             


Thr Trp Gly Ala Asn Lys Thr Asp Val Phe Leu Leu Glu Ser Leu Arg 
    530                 535                 540                 


Pro Pro Ser Gly Arg Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly 
545                 550                 555                 560 


Phe Val Lys Thr Cys Gly Ala Pro Pro Cys Asn Ile Tyr Gly Asp Gly 
                565                 570                 575     


Arg Asp Ala Gln Asn Glu Ser Asp Leu Phe Cys Pro Thr Asp Cys Phe 
            580                 585                 590         


Arg Lys His Pro Glu Ala Thr Tyr Ser Arg Cys Gly Ala Gly Pro Trp 
        595                 600                 605             


Leu Thr Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr 
    610                 615                 620                 


Pro Cys Thr Val Asn Phe Thr Leu Phe Lys Val Arg Met Phe Val Gly 
625                 630                 635                 640 


Gly Phe Glu His Arg Phe Thr Ala Ala Cys Asn Trp Thr Arg Gly Glu 
                645                 650                 655     


Arg Cys Asp Ile Glu Asp Arg Asp Arg Ser Glu Gln His Pro Leu Leu 
            660                 665                 670         


His Ser Thr Thr Glu Leu Ala Ile Leu Pro Cys Ser Phe Thr Pro Met 
        675                 680                 685             


Pro Ala Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp 
    690                 695                 700                 


Val Gln Tyr Leu Tyr Gly Ile Gly Ser Gly Met Val Gly Trp Ala Leu 
705                 710                 715                 720 


Lys Trp Glu Phe Val Ile Leu Ile Phe Leu Leu Leu Ala Asp Ala Arg 
                725                 730                 735     


Val Cys Val Ala Leu Trp Leu Ile Leu Thr Ile Ser Gln Ala Glu Ala 
            740                 745                 750         


<210>  36
<211>  754
<212>  PRT
<213>  Hepatitis C virus

<400>  36

Met Ser Thr Leu Pro Lys Pro Lys Arg Gln Thr Lys Arg Asn Thr Leu 
1               5                   10                  15      


Arg Arg Pro Lys Asn Val Lys Phe Pro Ala Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Glu Val Tyr Val Leu Pro Arg Arg Gly Pro Gln Leu Gly Val Arg Glu 
        35                  40                  45              


Val Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Thr Pro Lys Ala Arg Pro Arg Glu Gly Arg Ser Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Pro Pro Arg Gly Ser Arg Pro Ser Trp Gly Gln Asn Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Ile Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Ala Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Phe Ser Cys Leu Thr Cys Pro Ala Ser Ser Leu 
            180                 185                 190         


Glu Tyr Arg Asn Ala Ser Gly Leu Tyr Leu Leu Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Arg Ser Ile Val Tyr Glu Ala Asp Asp Val Ile Leu His Leu Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Glu Thr Asp Asn Asn Asn Thr Ser Cys Trp 
225                 230                 235                 240 


Thr Pro Ile Ser Pro Thr Val Ala Val Lys His Pro Gly Val Thr Thr 
                245                 250                 255     


Ala Ser Ile Arg Asn His Val Asn Met Leu Val Ala Pro Pro Thr Leu 
            260                 265                 270         


Cys Ser Ala Leu Tyr Val Glu Asp Ala Phe Gly Ala Val Ser Leu Val 
        275                 280                 285             


Gly Gln Ala Phe Thr Phe Arg Pro Arg Gln His Lys Thr Val Gln Thr 
    290                 295                 300                 


Cys Asn Cys Ser Ile Tyr Pro Gly His Val Ser Gly His Arg Met Ala 
305                 310                 315                 320 


Trp Asp Met Met Met Asn Trp Ser Pro Ala Ile Gly Leu Val Ile Ser 
                325                 330                 335     


His Leu Met Arg Leu Pro Gln Thr Phe Phe Asp Leu Val Val Gly Ala 
            340                 345                 350         


His Trp Gly Val Met Ala Gly Leu Ala Tyr Phe Ser Met Gln Gly Asn 
        355                 360                 365             


Trp Ala Lys Val Val Ile Val Leu Ile Met Phe Ser Gly Val Asp Ala 
    370                 375                 380                 


Thr Thr His Thr Thr Gly Gly Ser Ala Ala Gln Ala Thr Ala Gly Phe 
385                 390                 395                 400 


Thr Ser Phe Phe Thr Arg Gly Pro Ser Gln Asn Leu Gln Leu Val Asn 
                405                 410                 415     


Ser Asn Gly Ser Trp His Ile Asn Ser Thr Ala Leu Asn Cys Asn Asp 
            420                 425                 430         


Ser Leu Asn Thr Gly Phe Ile Ala Gly Leu Phe Tyr Tyr His Lys Phe 
        435                 440                 445             


Asn Ser Ser Gly Cys Pro Glu Arg Met Ser Ser Cys Lys Pro Ile Thr 
    450                 455                 460                 


Tyr Phe Asn Gln Gly Trp Gly Pro Leu Thr Asp Ala Asn Ile Asn Gly 
465                 470                 475                 480 


Pro Ser Glu Asp Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys 
                485                 490                 495     


Asn Ile Thr Lys Pro Leu Asn Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Ile Lys Gly Leu Pro Thr 
        515                 520                 525             


Tyr Arg Phe Gly Val Asn Glu Ser Asp Val Phe Leu Leu Thr Ser Leu 
    530                 535                 540                 


Arg Pro Pro Gln Gly Arg Trp Phe Gly Cys Val Trp Met Asn Ser Thr 
545                 550                 555                 560 


Gly Phe Val Lys Thr Cys Gly Ala Pro Pro Cys Asn Ile Tyr Gly Gly 
                565                 570                 575     


Met Lys Asp Ile Glu Ala Asn Gln Thr His Leu Lys Cys Pro Thr Asp 
            580                 585                 590         


Cys Phe Arg Lys His His Asp Ala Thr Phe Thr Arg Cys Gly Ser Gly 
        595                 600                 605             


Pro Trp Leu Thr Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp 
    610                 615                 620                 


His Tyr Pro Cys Thr Val Asn Phe Ser Ile Phe Lys Val Arg Met Phe 
625                 630                 635                 640 


Val Gly Gly His Glu His Arg Phe Ser Ala Ala Cys Asn Trp Thr Arg 
                645                 650                 655     


Gly Glu Arg Cys Asp Leu Glu Asp Arg Asp Arg Ser Glu Gln Gln Pro 
            660                 665                 670         


Leu Leu His Ser Thr Thr Asp Ser Leu Ile Leu Pro Cys Ser Phe Thr 
        675                 680                 685             


Pro Met Arg Arg Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile 
    690                 695                 700                 


Val Asp Val Gln Tyr Leu Tyr Gly Val Gly Ser Ala Val Val Gly Trp 
705                 710                 715                 720 


Ala Leu Lys Trp Glu Phe Val Val Leu Val Phe Leu Leu Leu Ala Asp 
                725                 730                 735     


Ala Arg Val Cys Val Ala Leu Trp Met Met Leu Leu Ile Ser Gln Ala 
            740                 745                 750         


Glu Ala 
        


<210>  37
<211>  751
<212>  PRT
<213>  Hepatitis C virus

<400>  37

Met Ser Thr Leu Pro Lys Pro Gln Arg Ile Thr Lys Arg Asn Ile Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Val Leu Pro Arg Arg Gly Pro Lys Leu Gly Val Arg Ala 
        35                  40                  45              


Val Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Ser Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Arg Ala Arg Arg Thr Glu Gly Arg Ser Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Ala Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Leu Thr Pro Thr Ala Gly Leu 
            180                 185                 190         


Glu Tyr Arg Asn Ala Ser Gly Leu Tyr Thr Val Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Gly Ser Ile Val Tyr Glu Ala Gly Asp Val Ile Leu His Leu Pro 
    210                 215                 220                 


Gly Cys Ile Pro Cys Val Arg Leu Asn Asn Ala Ser Lys Cys Trp Thr 
225                 230                 235                 240 


Pro Val Ser Pro Thr Val Ala Val Ser Arg Pro Gly Ala Ala Thr Ala 
                245                 250                 255     


Ser Leu Arg Thr His Val Asp Met Met Val Gly Ala Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ala Leu Phe Leu Val Gly 
        275                 280                 285             


Gln Gly Phe Ser Trp Arg His Arg Gln His Trp Thr Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Leu Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Ala Met Thr Leu Ile Val Ser Gln 
                325                 330                 335     


Val Leu Arg Leu Pro Gln Thr Met Phe Asp Leu Val Ile Gly Ala His 
            340                 345                 350         


Trp Gly Val Met Ala Gly Val Ala Tyr Tyr Ser Met Gln Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Phe Leu Val Leu Cys Leu Phe Ser Gly Val Asp Ala Ser 
    370                 375                 380                 


Thr Thr Ile Thr Gly Gly Val Ala Ala Ser Gly Ala Phe Thr Ile Thr 
385                 390                 395                 400 


Ser Leu Phe Ser Thr Gly Ala Lys Gln Pro Leu His Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Asn Thr Gly Phe Ile Ala Gly Leu Leu Tyr Tyr His Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Val Glu Arg Met Ser Ala Cys Ser Pro Leu Asp Arg 
    450                 455                 460                 


Phe Ala Gln Gly Trp Gly Pro Leu Gly Pro Ala Asn Ile Ser Gly Pro 
465                 470                 475                 480 


Ser Ser Glu Lys Pro Tyr Cys Trp His Tyr Ala Pro Arg Pro Cys Asp 
                485                 490                 495     


Thr Val Pro Ala Gln Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro 
            500                 505                 510         


Ser Pro Val Val Val Gly Ala Thr Asp Lys Arg Gly Ala Pro Thr Tyr 
        515                 520                 525             


Thr Trp Gly Glu Asn Glu Ser Asp Val Phe Leu Leu Glu Ser Ala Arg 
    530                 535                 540                 


Pro Pro Thr Glu Pro Trp Phe Gly Cys Thr Trp Met Asn Gly Ser Gly 
545                 550                 555                 560 


Tyr Val Lys Thr Cys Gly Ala Pro Pro Cys His Ile Tyr Gly Gly Arg 
                565                 570                 575     


Glu Gly Lys Ser Asn Asn Ser Leu Val Cys Pro Thr Asp Cys Phe Arg 
            580                 585                 590         


Lys His Pro Asp Ala Thr Tyr Asn Arg Cys Gly Ala Gly Pro Trp Leu 
        595                 600                 605             


Thr Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro 
    610                 615                 620                 


Cys Thr Val Asn Tyr Thr Ile Phe Lys Val Arg Met Phe Val Gly Gly 
625                 630                 635                 640 


Leu Glu His Arg Phe Asn Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg 
                645                 650                 655     


Cys Asn Leu Glu Asp Arg Asp Arg Ser Glu Met Tyr Pro Leu Leu His 
            660                 665                 670         


Ser Thr Thr Glu Gln Ala Ile Leu Pro Cys Ser Phe Val Pro Ile Pro 
        675                 680                 685             


Ala Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp Val 
    690                 695                 700                 


Gln Tyr Leu Tyr Gly Ile Ser Ser Gly Leu Val Gly Trp Ala Ile Lys 
705                 710                 715                 720 


Trp Glu Phe Val Ile Leu Ile Phe Leu Leu Leu Ala Asp Ala Arg Val 
                725                 730                 735     


Cys Val Val Leu Trp Met Met Met Leu Ile Ser Gln Ala Glu Ala 
            740                 745                 750     


<210>  38
<211>  745
<212>  PRT
<213>  Hepatitis C virus


<220>
<221>  misc_feature
<222>  (198)..(198)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (217)..(217)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (223)..(223)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (235)..(235)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (242)..(242)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (268)..(268)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (297)..(297)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (313)..(313)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (329)..(329)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (344)..(344)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (379)..(379)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (390)..(390)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (392)..(392)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (394)..(394)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (396)..(396)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (402)..(404)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (406)..(406)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (411)..(411)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (423)..(423)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (430)..(430)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (441)..(441)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (443)..(445)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (473)..(474)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (479)..(479)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (527)..(527)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (530)..(530)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (569)..(569)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (579)..(579)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (590)..(590)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (607)..(607)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (625)..(625)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (709)..(709)
<223>  Xaa can be any naturally occurring amino acid

<400>  38

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr 
            180                 185                 190         


Gln Val Arg Asn Ser Xaa Gly Leu Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Xaa Asp Ala Ile Leu His Xaa Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Xaa Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ala Xaa Thr Pro Thr Val Ala Thr Arg Asp Gly Lys Leu Pro Thr Thr 
                245                 250                 255     


Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Xaa Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Xaa His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Tyr Pro Gly His Ile Xaa Gly His Arg Met Ala Trp Asp 
305                 310                 315                 320 


Met Met Met Asn Trp Ser Pro Thr Xaa Ala Leu Val Val Ala Gln Leu 
                325                 330                 335     


Leu Arg Ile Pro Gln Ala Ile Xaa Asp Met Ile Ala Gly Ala His Trp 
            340                 345                 350         


Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn Trp Ala 
        355                 360                 365             


Lys Val Leu Val Val Leu Leu Leu Phe Ala Xaa Val Asp Ala Glu Thr 
    370                 375                 380                 


His Val Thr Gly Gly Xaa Ala Xaa Arg Xaa Thr Xaa Gly Leu Val Gly 
385                 390                 395                 400 


Leu Xaa Xaa Xaa Gly Xaa Lys Gln Asx Ile Xaa Leu Ile Asn Thr Asn 
                405                 410                 415     


Gly Ser Trp His Ile Asn Xaa Thr Ala Leu Asn Cys Asn Xaa Ser Leu 
            420                 425                 430         


Asn Thr Gly Trp Leu Ala Gly Leu Xaa Tyr Xaa Xaa Xaa Phe Asn Ser 
        435                 440                 445             


Ser Gly Cys Pro Glu Arg Leu Ala Ser Cys Arg Arg Leu Thr Asp Phe 
    450                 455                 460                 


Ala Gln Gly Trp Gly Pro Ile Ser Xaa Xaa Asn Gly Ser Gly Xaa Asp 
465                 470                 475                 480 


Glu Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys Gly Ile Val 
                485                 490                 495     


Pro Ala Lys Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser Pro 
            500                 505                 510         


Val Val Val Gly Thr Thr Asp Arg Ser Gly Ala Pro Thr Tyr Xaa Trp 
        515                 520                 525             


Gly Xaa Asn Asp Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro Pro 
    530                 535                 540                 


Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly Phe Thr 
545                 550                 555                 560 


Lys Val Cys Gly Ala Pro Pro Cys Xaa Ile Gly Gly Val Gly Asn Asn 
                565                 570                 575     


Thr Leu Xaa Cys Pro Thr Asp Cys Phe Arg Lys His Pro Xaa Ala Thr 
            580                 585                 590         


Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Xaa Val 
        595                 600                 605             


Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Ile Asn Tyr Thr 
    610                 615                 620                 


Xaa Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu Glu 
625                 630                 635                 640 


Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asx Leu Glu Asp Arg 
                645                 650                 655     


Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp Gln 
            660                 665                 670         


Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly Leu 
        675                 680                 685             


Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly Val 
    690                 695                 700                 


Gly Ser Ser Ile Xaa Ser Trp Ala Ile Lys Trp Glu Tyr Val Val Leu 
705                 710                 715                 720 


Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ser Cys Leu Trp Met 
                725                 730                 735     


Met Leu Leu Ile Ser Gln Ala Glu Ala 
            740                 745 


<210>  39
<211>  746
<212>  PRT
<213>  Hepatitis C virus

<400>  39

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr 
            180                 185                 190         


Gln Val Arg Asn Ser Thr Gly Leu Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Asp Asp Ala Ile Leu His Ala Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ile Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ala Met Thr Pro Thr Val Ala Thr Arg Asp Gly Lys Leu Pro Thr Thr 
                245                 250                 255     


Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Gly Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Leu His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Leu Tyr Pro Gly His Ile Ser Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ala Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Ser Val Asp Ala Glu 
    370                 375                 380                 


Thr His Val Thr Gly Gly Asn Ala Ala Arg Ser Thr Ser Gly Leu Val 
385                 390                 395                 400 


Gly Leu Phe Ser Ala Gly Pro Lys Gln Asp Ile Arg Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Asn Thr Gly Trp Leu Ala Gly Leu Leu Tyr Arg Tyr Asn Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Leu Ala Ser Cys Arg Arg Leu Thr Asp 
    450                 455                 460                 


Phe Ala Gln Gly Trp Gly Pro Ile Ser His Val Asn Gly Ser Gly Pro 
465                 470                 475                 480 


Asp Glu Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Lys Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Arg Ser Gly Ala Pro Thr Tyr Asn 
        515                 520                 525             


Trp Gly Glu Asn Asp Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly Phe 
545                 550                 555                 560 


Thr Lys Val Cys Gly Ala Pro Pro Cys Ala Ile Gly Gly Val Gly Asn 
                565                 570                 575     


Asn Thr Leu Arg Cys Pro Thr Asp Cys Phe Arg Lys His Pro Asp Ala 
            580                 585                 590         


Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Leu 
        595                 600                 605             


Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Ile Asn Tyr 
    610                 615                 620                 


Thr Val Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Glu Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asn Leu Glu Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Val Gly Ser Ser Ile Val Ser Trp Ala Ile Lys Trp Glu Tyr Val Val 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ser Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ser Gln Ala Glu Ala 
            740                 745     


<210>  40
<211>  750
<212>  PRT
<213>  Hepatitis C virus

<400>  40

Met Ser Thr Asn Pro Lys Pro Gln Arg Leu Thr Lys Arg Asn Thr Val 
1               5                   10                  15      


Arg Arg Pro Gln Asn Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Gly 
        35                  40                  45              


Thr Arg Lys Ser Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Arg 
    50                  55                  60                  


Ile Pro Lys Ala Ala Ser Ser Gln Gly Lys Ala Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Thr Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Met Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Leu Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr 
            180                 185                 190         


Glu Val Arg Asn Ser Ser Gly Val Tyr His Leu Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ala Ser Ile Val Tyr Glu Thr Asp Asn Ala Ile Leu His Glu Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Thr Ser Arg Cys Trp Glu 
225                 230                 235                 240 


Pro Val Ala Pro Thr Leu Ala Val Arg Tyr Arg Gly Ala Leu Thr Asp 
                245                 250                 255     


Asp Leu Arg Thr His Ile Asp Leu Val Val Ala Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Ile Cys Gly Ala Ile Phe Ile Ala Ser 
        275                 280                 285             


Gln Ala Val Leu Trp Lys Pro Gly Gly Gly Arg Ile Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Val Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Gln Asn Trp Ala Pro Ala Leu Ser Met Val Ala Ala Tyr 
                325                 330                 335     


Ala Val Arg Val Pro Gly Val Ile Ile Thr Thr Val Ala Gly Gly His 
            340                 345                 350         


Trp Gly Val Leu Phe Gly Leu Ala Tyr Phe Gly Met Ala Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Ile Leu Ile Met Leu Leu Met Ser Gly Val Asp Ala Glu 
    370                 375                 380                 


Thr Met Ala Val Gly Ala Arg Ala Ala His Thr Thr Gly Ala Leu Val 
385                 390                 395                 400 


Ser Leu Leu Asn Pro Gly Pro Ser Gln Arg Leu Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Gln Thr Gly Phe Ile Ala Ala Leu Phe Tyr Thr His Arg Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Lys Pro Leu Ser Asp 
    450                 455                 460                 


Phe Asp Gln Gly Trp Gly Pro Leu Trp Tyr Asn Ser Thr Glu Arg Pro 
465                 470                 475                 480 


Ser Asp Gln Arg Pro Tyr Cys Trp His Tyr Ala Pro Ser Pro Cys Gly 
                485                 490                 495     


Ile Val Pro Ala Lys Asp Val Cys Gly Pro Val Tyr Cys Phe Thr Pro 
            500                 505                 510         


Ser Pro Val Val Val Gly Thr Thr Asp Arg Arg Gly Val Pro Thr Tyr 
        515                 520                 525             


Thr Trp Gly Glu Asn Glu Ser Asp Val Phe Leu Leu Asn Ser Thr Arg 
    530                 535                 540                 


Pro Pro Gln Gly Ser Trp Phe Gly Cys Ser Trp Met Asn Thr Thr Gly 
545                 550                 555                 560 


Phe Thr Lys Thr Cys Gly Gly Pro Pro Cys Lys Ile Arg Pro Gln Gly 
                565                 570                 575     


Ala Gln Ser Asn Thr Ser Leu Thr Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Arg Ala Thr Tyr Ser Ala Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Met Val His Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Phe Thr Ile His Lys Val Arg Leu Tyr Ile Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Asp Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys 
                645                 650                 655     


Asp Leu Glu Asp Arg Asp Arg Val Asp Met Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Leu Ala Ile Leu Pro Cys Ser Phe Val Pro Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp Ala Gln 
    690                 695                 700                 


Tyr Leu Tyr Gly Leu Ser Pro Ala Ile Ile Ser Trp Ala Ile Arg Trp 
705                 710                 715                 720 


Glu Trp Val Val Leu Val Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Met Met Leu Met Ala Gln Ala Glu Ala 
            740                 745                 750 


<210>  41
<211>  750
<212>  PRT
<213>  Hepatitis C virus

<400>  41

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Glu Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Thr 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ala Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Arg Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Ser Gly Ala Ala Arg Ala Val Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Phe Pro Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Val Pro Val Ser Ala Ala 
            180                 185                 190         


Gln Val Lys Asn Thr Ser Ser Ser Tyr Met Val Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Asp Ser Ile Thr Trp Gln Leu Glu Ala Ala Val Leu His Val Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Arg Val Gly Asn Thr Ser Arg Cys Trp Val 
225                 230                 235                 240 


Pro Val Ser Pro Asn Met Ala Val Arg Gln Pro Gly Ala Leu Thr Gln 
                245                 250                 255     


Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Phe Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala Ala 
        275                 280                 285             


Gln Val Phe Ile Val Ser Pro Gln Tyr His Trp Phe Val Gln Glu Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Val Met Arg Val Pro Glu Val Ile Ile Asp Ile Val Ser Gly Ala His 
            340                 345                 350         


Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Ile Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala Gly 
    370                 375                 380                 


Thr Thr Thr Val Gly Gly Ala Val Ala Arg Ser Thr Asn Val Ile Ala 
385                 390                 395                 400 


Gly Val Phe Ser His Gly Pro Gln Gln Asn Ile Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Asn Thr Gly Phe Leu Ala Ala Leu Phe Tyr Thr Asn Arg Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Gly Arg Leu Ser Ala Cys Arg Asn Ile Glu Ala 
    450                 455                 460                 


Phe Arg Ile Gly Trp Gly Thr Leu Gln Tyr Glu Asp Asn Val Thr Asn 
465                 470                 475                 480 


Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys 
                485                 490                 495     


Gly Val Val Pro Ala Arg Ser Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Arg Gly Val Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Gln Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Thr 
545                 550                 555                 560 


Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Thr Arg Ala Asp 
                565                 570                 575     


Phe Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Ala Thr Tyr Ile Lys Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Lys Cys Leu Val His Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Phe Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Asp Leu Glu Asp Arg Asp Arg Ser Gln Leu Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Ile Leu Pro Cys Thr Tyr Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Tyr Met Tyr Gly Leu Ser Pro Ala Ile Thr Lys Tyr Val Val Arg Trp 
705                 710                 715                 720 


Glu Trp Val Val Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala 
            740                 745                 750 


<210>  42
<211>  749
<212>  PRT
<213>  Hepatitis C virus

<400>  42

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Thr Pro Val Ser Ala Ala 
            180                 185                 190         


Gln Val Lys Asn Thr Ser Asp Ile Tyr Met Val Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Asp Ser Ile Thr Trp Gln Leu Gln Ala Ala Ala Leu His Val Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Arg Val Gly Asn Thr Ser Arg Cys Trp Ile 
225                 230                 235                 240 


Pro Val Ser Pro Asn Val Ala Val Arg Gln Pro Gly Ala Leu Thr Gln 
                245                 250                 255     


Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala Ala 
        275                 280                 285             


Gln Met Phe Ile Ile Ser Pro Gln His His Trp Phe Val Gln Glu Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Thr Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Val Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Gly Gly Ala His 
            340                 345                 350         


Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Val Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala His 
    370                 375                 380                 


Thr Arg Thr Gly Ser Ser Val Gly Tyr Ala Thr Ser Gly Ile Val Gly 
385                 390                 395                 400 


Leu Phe Thr Ser Gly Pro Lys Gln Asn Ile Gln Leu Ile Asn Thr Asn 
                405                 410                 415     


Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser Leu 
            420                 425                 430         


Asn Thr Gly Phe Ile Val Ser Leu Phe Tyr Ala Arg Asn Phe Asn Ser 
        435                 440                 445             


Thr Gly Cys Pro Glu Arg Leu Ser Ala Cys Arg Gly Ile Glu Gly Phe 
    450                 455                 460                 


Arg Ile Gly Trp Gly Thr Leu Gln Tyr Glu Asp Asn Val Thr Asn Pro 
465                 470                 475                 480 


Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Gln Cys Gly 
                485                 490                 495     


Ile Val Pro Ala Gly Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro 
            500                 505                 510         


Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Val Pro Thr Tyr 
        515                 520                 525             


Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr Arg 
    530                 535                 540                 


Pro Pro Val Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly 
545                 550                 555                 560 


Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Ala Asp Phe 
                565                 570                 575     


Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys His 
            580                 585                 590         


Pro Glu Ala Thr Tyr Ile Lys Cys Gly Ser Gly Pro Trp Leu Thr Pro 
        595                 600                 605             


Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr 
    610                 615                 620                 


Val Asn Tyr Ser Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val Glu 
625                 630                 635                 640 


His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys Asn 
                645                 650                 655     


Leu Glu Asp Arg Asp Arg Ser Gln Leu Thr Pro Leu Leu His Ser Thr 
            660                 665                 670         


Thr Glu Trp Ala Ile Leu Pro Cys Thr Tyr Ser Asp Leu Pro Ala Leu 
        675                 680                 685             


Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln Tyr 
    690                 695                 700                 


Met Tyr Gly Leu Ser Pro Ala Leu Thr Lys Tyr Val Val Arg Trp Glu 
705                 710                 715                 720 


Trp Val Val Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ala 
                725                 730                 735     


Cys Val Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala 
            740                 745                 


<210>  43
<211>  749
<212>  PRT
<213>  Hepatitis C virus


<220>
<221>  misc_feature
<222>  (386)..(386)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (392)..(394)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (398)..(399)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (444)..(444)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (496)..(496)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (525)..(525)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (538)..(538)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (712)..(712)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (722)..(722)
<223>  Xaa can be any naturally occurring amino acid

<400>  43

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys His Arg Arg Ser Thr Gly Lys Ser Trp Gly Thr Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Thr Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Ile Pro Val Ser Ala Ala 
            180                 185                 190         


Gln Val Lys Asn Thr Ser Ser Gly Tyr Met Val Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Asp Ser Ile Thr Trp Gln Leu Glu Ala Ala Val Leu His Val Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Lys Val Gly Asn Thr Ser Arg Cys Trp Ile 
225                 230                 235                 240 


Pro Val Ser Pro Asn Val Ala Val Gln Arg Pro Gly Ala Leu Thr Gln 
                245                 250                 255     


Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Phe Cys Gly Gly Val Met Leu Ala Ala 
        275                 280                 285             


Gln Met Phe Ile Val Ser Pro Gln His His Trp Phe Val Gln Glu Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly Thr Ile Ser Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Met Ala Tyr 
                325                 330                 335     


Val Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Val Val Ile Leu Leu Leu Thr Ala Gly Val Asp Ala His 
    370                 375                 380                 


Thr Xaa Ile Gly Ser Ala Val Xaa Xaa Xaa Thr Ser Gly Xaa Xaa Gly 
385                 390                 395                 400 


Leu Phe Tyr Arg Gly Ala Gln Gln Asn Ile Gln Leu Ile Asn Thr Asn 
                405                 410                 415     


Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser Leu 
            420                 425                 430         


Asn Thr Gly Phe Leu Ala Ser Leu Phe Tyr Ala Xaa Arg Phe Asn Ser 
        435                 440                 445             


Ser Gly Cys Pro Glu Arg Leu Ser Val Cys Arg Asn Ile Glu Ala Phe 
    450                 455                 460                 


Arg Ile Gly Trp Gly Thr Leu Gln Tyr Glu Asp Asn Val Thr Asn Pro 
465                 470                 475                 480 


Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Xaa 
                485                 490                 495     


Ile Val Pro Ala Gly Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro 
            500                 505                 510         


Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Xaa Pro Thr Tyr 
        515                 520                 525             


Thr Trp Gly Glu Asn Glu Thr Asp Val Xaa Leu Leu Asn Ser Thr Arg 
    530                 535                 540                 


Pro Pro Gln Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly 
545                 550                 555                 560 


Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Thr Arg Ala Asp Phe 
                565                 570                 575     


Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys His 
            580                 585                 590         


Pro Glu Ala Thr Tyr Ile Lys Cys Gly Ser Gly Pro Trp Leu Thr Pro 
        595                 600                 605             


Arg Cys Met Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr 
    610                 615                 620                 


Val Asn Tyr Ser Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val Glu 
625                 630                 635                 640 


His Arg Leu Met Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys Asp 
                645                 650                 655     


Leu Glu Asp Arg Asp Arg Ser Gln Leu Ser Pro Leu Leu His Ser Thr 
            660                 665                 670         


Thr Glu Trp Ala Ile Leu Pro Cys Ser Tyr Ser Asp Leu Pro Ala Leu 
        675                 680                 685             


Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln Tyr 
    690                 695                 700                 


Met Tyr Gly Leu Ser Pro Ala Xaa Thr Lys Tyr Val Val Arg Trp Glu 
705                 710                 715                 720 


Trp Xaa Val Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ala 
                725                 730                 735     


Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala 
            740                 745                 


<210>  44
<211>  750
<212>  PRT
<213>  Hepatitis C virus

<400>  44

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Ser 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Val Pro Val Ser Ala Val 
            180                 185                 190         


Gln Val Lys Asn Ile Ser Asp Ser Tyr Met Val Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Asp Ser Ile Thr Trp Gln Leu Gln Ala Ala Val Leu His Val Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Lys Met Gly Asn Ile Ser Arg Cys Trp Ile 
225                 230                 235                 240 


Pro Val Ser Pro Asn Val Ala Val Gln Arg Pro Gly Ala Leu Thr Gln 
                245                 250                 255     


Gly Leu Arg Ala His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala Ala 
        275                 280                 285             


Gln Met Phe Ile Val Ser Pro Gln His His His Phe Val Gln Glu Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly Ala Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Ser Gly Ala His 
            340                 345                 350         


Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Val Val Ile Leu Leu Leu Thr Ala Gly Val Asp Ala His 
    370                 375                 380                 


Thr Arg Ser Ile Ala Gly Ser Val Ala His Ala Thr Ser Gly Leu Ala 
385                 390                 395                 400 


Gly Leu Phe Thr Ser Gly Ala Lys Gln Asn Ile Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Asn Thr Gly Phe Ile Ala Ser Leu Phe Tyr Thr Tyr Arg Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Leu Ser Ala Cys Arg Gly Ile Gln Ala 
    450                 455                 460                 


Phe Arg Ile Gly Trp Gly Thr Leu Arg Tyr Glu Asp Asn Val Thr Asn 
465                 470                 475                 480 


Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Gln Cys 
                485                 490                 495     


Gly Ile Val Ser Ala Arg Ser Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Val Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Ile Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Gly Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Thr 
545                 550                 555                 560 


Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Ala Asp 
                565                 570                 575     


Phe Asn Ala Ser Met Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Ala Thr Tyr Ile Lys Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Ile Asn Tyr Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Pro Cys 
                645                 650                 655     


Asn Leu Glu Asp Arg Asp Arg Ser Gln Leu Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Ile Leu Pro Cys Ser Tyr Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Tyr Met Tyr Gly Leu Ser Pro Ala Leu Thr Lys Tyr Ile Val Arg Trp 
705                 710                 715                 720 


Glu Trp Val Val Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala 
            740                 745                 750 


<210>  45
<211>  750
<212>  PRT
<213>  Hepatitis C virus


<220>
<221>  misc_feature
<222>  (458)..(458)
<223>  Xaa can be any naturally occurring amino acid

<400>  45

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Val Thr Val Pro Val Ser Ala Val 
            180                 185                 190         


Gln Val Lys Asn Thr Ser Glu Thr Tyr Met Val Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Asp Ser Ile Thr Trp Gln Leu Gln Ala Ala Val Leu His Val Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Arg Thr Gly Asn Thr Ser Arg Cys Trp Ile 
225                 230                 235                 240 


Pro Val Ser Pro Asn Val Ala Val Gln Gln Pro Gly Ala Leu Thr Gln 
                245                 250                 255     


Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Val Leu Ala Ala 
        275                 280                 285             


Gln Leu Phe Ile Val Ser Pro Arg Arg His Trp Phe Val Gln Glu Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly Ala Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Thr Thr Met Val Leu Ala Tyr 
                325                 330                 335     


Ala Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Ser Gly Ala His 
            340                 345                 350         


Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Ala Val Ile Leu Leu Leu Thr Ala Gly Val Glu Ala Arg 
    370                 375                 380                 


Thr His Thr Thr Gly Ser Val Ala Gly Arg Thr Thr Ser Gly Phe Ala 
385                 390                 395                 400 


Gly Ile Phe Thr Ser Gly Pro Lys Gln Asn Ile Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Asn Thr Gly Phe Met Ala Ala Leu Phe Tyr Thr Lys Asn Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Leu Ser Xaa Cys Arg Asn Ile Glu Ala 
    450                 455                 460                 


Phe Arg Ile Gly Trp Gly Thr Leu Gln Tyr Glu Asp Asp Val Thr Asn 
465                 470                 475                 480 


Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Gln Cys 
                485                 490                 495     


Gly Ile Phe Pro Ala Gly Ser Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asn Lys Leu Gly Val Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Ile Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Arg Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Thr 
545                 550                 555                 560 


Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Ala Asp 
                565                 570                 575     


Phe Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Glu Ala Thr Tyr Ile Lys Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Tyr Ser Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Thr Ala Ala Cys Asn Phe Ser Arg Gly Asp Arg Cys 
                645                 650                 655     


Asn Leu Glu Asp Arg Asp Arg Ser Gln Leu Thr Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Ile Leu Pro Cys Ser Tyr Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Tyr Met Tyr Gly Leu Thr Pro Ala Leu Thr Lys Tyr Val Val Arg Trp 
705                 710                 715                 720 


Glu Trp Val Val Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala 
            740                 745                 750 


<210>  46
<211>  751
<212>  PRT
<213>  Hepatitis C virus

<400>  46

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Gln Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Thr 
        35                  40                  45              


Ala Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Arg Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Ile Pro Ala Ser Ala Val 
            180                 185                 190         


Glu Val Lys Asn Thr Ser Thr Gly Tyr Met Val Thr Asn Asp Cys Ala 
        195                 200                 205             


Asn Ser Ser Ile Thr Trp Gln Leu His Ala Ala Val Leu His Val Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Arg Val Asp Asn Asn Thr Ser Arg Cys Trp 
225                 230                 235                 240 


Ile Pro Val Ser Pro Asn Ile Ala Val Gln Arg Pro Gly Ala Leu Thr 
                245                 250                 255     


Gln Gly Leu Arg Ser His Ile Asp Ile Val Val Met Ser Ala Thr Leu 
            260                 265                 270         


Cys Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala 
        275                 280                 285             


Ala Gln Met Phe Val Val Ser Pro Glu His His Trp Phe Val Gln Glu 
    290                 295                 300                 


Cys Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala 
305                 310                 315                 320 


Trp Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala 
                325                 330                 335     


Tyr Ala Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Gly Gly Ala 
            340                 345                 350         


His Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala 
        355                 360                 365             


Trp Ala Lys Val Val Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala 
    370                 375                 380                 


Tyr Thr His Thr Val Gly Gly Ala Ala Ala Ser Thr Ala Asn Ser Ile 
385                 390                 395                 400 


Ala Gly Leu Leu Ser Arg Gly Pro Arg Gln Asn Leu Gln Leu Ile Asn 
                405                 410                 415     


Ser Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys His Asp 
            420                 425                 430         


Ser Leu Gln Thr Gly Phe Ile Thr Ala Leu Phe Tyr Ala Arg His Phe 
        435                 440                 445             


Asn Ser Ser Gly Cys Pro Glu Arg Leu Ala Ala Cys Arg Asn Ile Glu 
    450                 455                 460                 


Ala Phe Arg Val Gly Trp Gly Ala Leu Gln Tyr Glu Asp Asn Val Thr 
465                 470                 475                 480 


Asn Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Gln 
                485                 490                 495     


Cys Gly Ile Val Pro Ala Arg Ser Val Cys Gly Pro Val Tyr Cys Phe 
            500                 505                 510         


Thr Pro Ser Pro Val Val Val Gly Thr Thr Asp Lys Leu Gly Val Pro 
        515                 520                 525             


Thr Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser 
    530                 535                 540                 


Thr Arg Pro Pro Gln Gly Pro Trp Phe Gly Cys Thr Trp Met Asn Ser 
545                 550                 555                 560 


Thr Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Thr Arg Ala 
                565                 570                 575     


Asp Phe Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg 
            580                 585                 590         


Lys His Pro Asp Ala Thr Tyr Asn Lys Cys Gly Ser Gly Pro Trp Leu 
        595                 600                 605             


Thr Pro Arg Cys Leu Ile Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro 
    610                 615                 620                 


Cys Thr Val Asn Tyr Thr Thr Phe Lys Ile Arg Met Tyr Val Gly Gly 
625                 630                 635                 640 


Val Glu His Arg Leu Met Ala Ala Cys Asn Phe Thr Arg Gly Asp Ser 
                645                 650                 655     


Cys Asp Leu Ser Gln Arg Asp Arg Gly Gln Leu Ser Pro Leu Leu His 
            660                 665                 670         


Ser Thr Thr Glu Trp Ala Ile Leu Pro Cys Ser Phe Ser Asp Leu Pro 
        675                 680                 685             


Ala Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val 
    690                 695                 700                 


Gln Tyr Met Tyr Gly Leu Ser Pro Ala Leu Thr Lys Tyr Ile Val Arg 
705                 710                 715                 720 


Trp Glu Trp Val Val Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val 
                725                 730                 735     


Cys Ala Cys Ile Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala 
            740                 745                 750     


<210>  47
<211>  750
<212>  PRT
<213>  Hepatitis C virus

<400>  47

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Thr Pro Val Ser Ala Ala 
            180                 185                 190         


Glu Val Lys Asn Ile Ser Thr Gly Tyr Met Val Thr Asn Asp Cys Thr 
        195                 200                 205             


Asn Asp Ser Ile Thr Trp Gln Leu Gln Ala Ala Val Leu His Val Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Lys Val Gly Asn Thr Ser Arg Cys Trp Ile 
225                 230                 235                 240 


Pro Val Ser Pro Asn Val Ala Val Gln Gln Pro Gly Ala Leu Thr Gln 
                245                 250                 255     


Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala Ala 
        275                 280                 285             


Gln Met Phe Ile Val Ser Pro Gln His His Trp Phe Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Gly Gly Ala His 
            340                 345                 350         


Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Val Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala Gln 
    370                 375                 380                 


Thr His Thr Val Gly Gly Ser Thr Ala His Asn Ala Arg Thr Leu Thr 
385                 390                 395                 400 


Gly Met Phe Ser Leu Gly Ala Arg Gln Lys Ile Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu His Thr Gly Phe Leu Ala Ser Leu Phe Tyr Thr His Ser Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ser Ala Cys Arg Ser Ile Glu Ala 
    450                 455                 460                 


Phe Arg Val Gly Trp Gly Ala Leu Gln Tyr Glu Asp Asn Val Thr Asn 
465                 470                 475                 480 


Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Gln Cys 
                485                 490                 495     


Gly Val Val Ser Ala Ser Ser Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Ala Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Gln Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Thr 
545                 550                 555                 560 


Gly Tyr Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Ala Asp 
                565                 570                 575     


Phe Asn Ala Ser Met Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Thr Thr Tyr Ile Lys Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Ile Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Tyr Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Asn Leu Glu Asp Arg Asp Arg Ser Gln Leu Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Ile Leu Pro Cys Thr Tyr Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Phe Met Tyr Gly Leu Ser Pro Ala Leu Thr Lys Tyr Ile Val Arg Trp 
705                 710                 715                 720 


Glu Trp Val Val Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala 
            740                 745                 750 


<210>  48
<211>  750
<212>  PRT
<213>  Hepatitis C virus

<400>  48

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Thr Pro Val Ser Ala Ala 
            180                 185                 190         


Glu Val Lys Asn Ile Ser Thr Gly Tyr Met Val Thr Asn Asp Cys Thr 
        195                 200                 205             


Asn Asp Ser Ile Thr Trp Gln Leu Gln Ala Ala Val Leu His Val Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Lys Val Gly Asn Ala Ser Gln Cys Trp Ile 
225                 230                 235                 240 


Pro Val Ser Pro Asn Val Ala Val Gln Arg Pro Gly Ala Leu Thr Gln 
                245                 250                 255     


Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala Ala 
        275                 280                 285             


Gln Met Phe Ile Val Ser Pro Gln His His Trp Phe Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Ser Gly Ala His 
            340                 345                 350         


Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Val Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala Arg 
    370                 375                 380                 


Thr His Thr Val Gly Gly Ser Ala Ala Gln Thr Thr Gly Arg Leu Thr 
385                 390                 395                 400 


Ser Leu Phe Asp Met Gly Pro Arg Gln Lys Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu His Thr Gly Phe Ile Ala Ser Leu Phe Tyr Thr His Ser Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ser Ala Cys Arg Ser Ile Glu Ala 
    450                 455                 460                 


Phe Arg Val Gly Trp Gly Ala Leu Gln Tyr Glu Asp Asn Val Thr Asn 
465                 470                 475                 480 


Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Gln Cys 
                485                 490                 495     


Gly Val Val Ser Ala Lys Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Ala Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Leu Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Ser 
545                 550                 555                 560 


Gly Tyr Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Thr Arg Ala Asp 
                565                 570                 575     


Phe Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Thr Thr Tyr Leu Lys Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Ile Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Tyr Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Asn Leu Glu Asp Arg Asp Arg Ser Gln Leu Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Ile Leu Pro Cys Ser Tyr Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Phe Met Tyr Gly Leu Ser Pro Ala Leu Thr Lys Tyr Ile Val Arg Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala 
            740                 745                 750 


<210>  49
<211>  750
<212>  PRT
<213>  Hepatitis C virus

<400>  49

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Thr Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Leu Gly Arg Val Ile Asp Thr Ile Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Val Thr Val Pro Val Ser Ala Val 
            180                 185                 190         


Glu Val Arg Asn Ile Ser Ser Ser Tyr Tyr Ala Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Asn Ser Ile Thr Trp Gln Leu Thr Asp Ala Val Leu His Leu Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Asn Asp Asn Gly Thr Leu His Cys Trp Ile 
225                 230                 235                 240 


Gln Val Thr Pro Asn Val Ala Val Lys His Arg Gly Ala Leu Thr Arg 
                245                 250                 255     


Ser Leu Arg Thr His Val Asp Met Ile Val Met Ala Ala Thr Ala Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Val Cys Gly Ala Val Met Ile Leu Ser 
        275                 280                 285             


Gln Ala Phe Met Val Ser Pro Gln Arg His Asn Phe Thr Gln Glu Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Gln Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Leu Ser Trp Ser Pro Thr Leu Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Ala Arg Val Pro Glu Leu Val Leu Glu Ile Ile Phe Gly Gly His 
            340                 345                 350         


Trp Gly Val Val Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Ile Ala Ile Leu Leu Leu Val Ala Gly Val Asp Ala Thr 
    370                 375                 380                 


Thr Tyr Ser Ser Gly Gln Glu Ala Gly Arg Thr Val Ala Gly Phe Ala 
385                 390                 395                 400 


Gly Leu Phe Thr Thr Gly Ala Lys Gln Asn Leu Tyr Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Gln Thr Gly Phe Leu Ala Ser Leu Phe Tyr Thr His Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Leu Ser Ser Cys Arg Gly Leu Asp Asp 
    450                 455                 460                 


Phe Arg Ile Gly Trp Gly Thr Leu Glu Tyr Glu Thr Asn Val Thr Asn 
465                 470                 475                 480 


Asp Gly Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys 
                485                 490                 495     


Gly Ile Val Pro Ala Arg Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Lys Gln Gly Val Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Arg Gly Ala Trp Phe Gly Cys Thr Trp Met Asn Gly Thr 
545                 550                 555                 560 


Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Lys Asp 
                565                 570                 575     


Tyr Asn Ser Thr Ile Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Ala Thr Tyr Leu Lys Cys Gly Ala Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Phe Thr Ile Phe Lys Ala Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Phe Ser Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Arg Leu Glu Asp Arg Asp Arg Gly Gln Gln Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Val Leu Pro Cys Ser Phe Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Tyr Leu Tyr Gly Leu Ser Pro Ala Leu Thr Arg Tyr Ile Val Lys Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Ile Leu Gly Gln Ala Glu Ala 
            740                 745                 750 


<210>  50
<211>  750
<212>  PRT
<213>  Hepatitis C virus

<400>  50

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Thr Trp Gly Pro Ser Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Leu Gly Arg Val Ile Asp Thr Ile Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Tyr Ala Thr Arg Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Val Thr Val Pro Val Ser Ser Val 
            180                 185                 190         


Glu Ile Arg Asn Ile Ser Thr Ser Tyr Tyr Ala Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Asn Ser Ile Thr Trp Gln Leu Thr Asn Ala Val Leu His Leu Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Asn Asp Asn Gly Thr Leu Arg Cys Trp Ile 
225                 230                 235                 240 


Gln Val Thr Pro Asn Val Ala Val Lys His Arg Gly Ala Leu Thr His 
                245                 250                 255     


Asn Leu Arg Ala His Val Asp Val Ile Val Met Ala Ala Thr Val Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Val Cys Gly Ala Val Met Ile Val Ser 
        275                 280                 285             


Gln Ala Leu Ile Val Ser Pro Glu Arg His Asn Phe Thr Gln Glu Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Gln Gly His Ile Thr Gly Gln Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Leu Asn Trp Ser Pro Thr Leu Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Ala Arg Val Pro Glu Leu Val Leu Glu Ile Val Phe Gly Gly His 
            340                 345                 350         


Trp Gly Val Val Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Ile Ala Ile Leu Leu Leu Val Ala Gly Val Asp Ala Thr 
    370                 375                 380                 


Thr Tyr Ser Thr Gly Ala Thr Val Gly Arg Thr Val Gly Ser Phe Ala 
385                 390                 395                 400 


Gly Leu Phe Lys Leu Gly Ala Gln Gln Asn Val Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu His Thr Gly Phe Met Ala Ala Leu Phe Tyr Ala Asn Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Leu Ser Ser Cys Arg Gly Leu Asp Asp 
    450                 455                 460                 


Phe Arg Ile Gly Trp Gly Thr Leu Glu Tyr Glu Thr Asn Val Thr Asn 
465                 470                 475                 480 


Val Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys 
                485                 490                 495     


Gly Ile Val Pro Ala Gln Ser Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Gln Gly Val Pro Thr 
        515                 520                 525             


Tyr Asn Trp Gly Asp Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Arg Gly Ala Trp Phe Gly Cys Thr Trp Met Asn Gly Thr 
545                 550                 555                 560 


Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Lys Asp 
                565                 570                 575     


Phe Asn Ser Thr Leu Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Ala Thr Tyr Val Lys Cys Gly Ala Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Ile Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Phe Thr Ile Phe Lys Val Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Phe Ser Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Arg Leu Glu Asp Arg Asp Arg Gly Gln Gln Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Val Leu Pro Cys Ser Phe Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Tyr Leu Tyr Gly Leu Ser Pro Ala Val Thr Lys Tyr Ile Val Lys Trp 
705                 710                 715                 720 


Glu Trp Val Val Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Ile Leu Gly Gln Ala Glu Ala 
            740                 745                 750 


<210>  51
<211>  750
<212>  PRT
<213>  Hepatitis C virus

<400>  51

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro His Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Ile Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Ile Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Val Thr Val Pro Val Ser Ala Val 
            180                 185                 190         


Glu Val Arg Asn Ile Ser Ser Ser Tyr Tyr Ala Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Asn Ser Ile Thr Trp Gln Leu Glu Asn Ala Val Leu His Leu Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Asn Asp Asn Gly Thr Leu Arg Cys Trp Thr 
225                 230                 235                 240 


Gln Val Thr Pro Asn Val Ala Val Lys His Arg Gly Ala Leu Thr Gln 
                245                 250                 255     


Asn Leu Arg Thr His Val Asp Val Ile Val Val Ala Ala Thr Val Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Val Cys Gly Ala Val Met Ile Ala Ser 
        275                 280                 285             


Gln Ala Leu Ile Val Ser Pro Ala Arg His Asn Phe Thr Gln Glu Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Gln Gly Arg Ile Thr Gly His His Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Leu Asn Trp Ser Pro Thr Ile Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Ala Arg Ile Pro Glu Leu Val Leu Glu Val Ile Phe Gly Gly His 
            340                 345                 350         


Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Ile Val Ile Leu Leu Leu Val Ala Gly Val Asp Ala Arg 
    370                 375                 380                 


His His Thr Thr Gly Leu Gln Ala Gly Lys Thr Leu Ala Arg Val Thr 
385                 390                 395                 400 


Ser Leu Phe Ser Ile Gly Ala Lys Gln Asn Ile Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Gln Thr Gly Phe Ile Ala Ser Leu Phe Tyr Val Asn Asn Ile Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ser Ser Cys Arg Glu Leu Asp Asp 
    450                 455                 460                 


Phe Arg Ile Gly Trp Gly Thr Leu Glu Tyr Glu Thr Asn Val Thr Asn 
465                 470                 475                 480 


Asp Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys 
                485                 490                 495     


Gly Ile Val Pro Ala Arg Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Ile Val Val Gly Thr Thr Asp Lys Gln Gly Val Pro Thr 
        515                 520                 525             


Tyr Ser Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Arg Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Gly Thr 
545                 550                 555                 560 


Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Arg Asp 
                565                 570                 575     


Tyr Asn Ser Thr Leu Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Thr Thr Tyr Leu Lys Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Lys Cys Leu Val Glu Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Phe Thr Ile Phe Lys Val Arg Met Tyr Val Gly Ala Val 
625                 630                 635                 640 


Glu His Arg Phe Ser Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Arg Leu Glu Asp Arg Asp Arg Gly Gln Gln Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Val Leu Pro Cys Ser Phe Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Tyr Leu Tyr Gly Leu Ser Pro Ala Ile Thr Arg Tyr Ile Val Lys Trp 
705                 710                 715                 720 


Glu Trp Val Val Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Ile Leu Gly Gln Ala Glu Ala 
            740                 745                 750 


<210>  52
<211>  750
<212>  PRT
<213>  Hepatitis C virus

<400>  52

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Thr Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Leu Gly Arg Val Ile Asp Thr Ile Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Cys Thr Val Pro Val Ser Ala Val 
            180                 185                 190         


Glu Val Arg Asn Ile Ser Thr Ser Tyr Tyr Ala Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Thr Ser Ile Thr Trp Gln Leu Thr Asn Ala Val Leu His Leu Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Asn Asp Asn Gly Thr Leu Arg Cys Trp Ile 
225                 230                 235                 240 


Gln Val Thr Pro Asn Val Ala Val Lys His Arg Gly Ala Leu Thr His 
                245                 250                 255     


Asn Leu Arg Thr His Val Asp Val Ile Val Met Ala Ala Thr Val Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Ile Cys Gly Ala Val Met Ile Val Ser 
        275                 280                 285             


Gln Ala Phe Ile Ile Ser Pro Glu Arg His Asn Phe Thr Gln Glu Cys 
    290                 295                 300                 


Asn Cys Ser Met Tyr Gln Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Leu Asn Trp Ser Pro Thr Leu Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Ala Arg Val Pro Glu Leu Val Leu Glu Val Ile Phe Gly Gly His 
            340                 345                 350         


Trp Gly Val Val Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Ile Ala Ile Leu Leu Leu Val Ala Gly Val Asp Ala Asn 
    370                 375                 380                 


Thr Tyr Ser Ser Gly Val Thr Val Gly His Thr Thr Ser Thr Phe Ala 
385                 390                 395                 400 


Asn Ile Phe Ser Val Gly Pro Ser Gln Lys Ile Asn Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Gln Thr Gly Phe Leu Ala Ser Leu Phe Tyr Val Arg Asn Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Arg Glu Arg Leu Ser Ser Cys Arg Arg Leu Asp Asp 
    450                 455                 460                 


Phe Arg Ile Gly Trp Gly Thr Leu Glu Tyr Glu Thr Asn Val Thr Asn 
465                 470                 475                 480 


Asp Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys 
                485                 490                 495     


Gly Ile Val Ser Ala Arg Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Gln Gly Val Pro Thr 
        515                 520                 525             


Tyr Ser Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Arg Gly Ala Trp Phe Gly Cys Thr Trp Met Asn Gly Thr 
545                 550                 555                 560 


Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Arg Asp 
                565                 570                 575     


Tyr Asn Ser Thr Leu Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Thr Thr Tyr Leu Lys Cys Gly Ala Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Lys Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Phe Thr Ile Phe Lys Val Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Ser Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Gly Leu Glu Asp Arg Asp Arg Gly Gln Gln Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Val Leu Pro Cys Ser Phe Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Tyr Leu Tyr Gly Leu Ser Pro Ala Ile Thr Arg Tyr Ile Val Lys Trp 
705                 710                 715                 720 


Glu Trp Val Val Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Ile Leu Gly Gln Ala Glu Ala 
            740                 745                 750 


<210>  53
<211>  750
<212>  PRT
<213>  Hepatitis C virus


<220>
<221>  misc_feature
<222>  (203)..(203)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (295)..(295)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (343)..(343)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (401)..(401)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (426)..(426)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (626)..(626)
<223>  Xaa can be any naturally occurring amino acid

<400>  53

Met Ser Thr Asp Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Ala Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Pro Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Thr Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Ile Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Val 
            180                 185                 190         


Glu Val Arg Asn Ile Ser Ser Gly Tyr Tyr Xaa Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Ser Ser Ile Thr Trp Gln Leu Thr Asn Ala Val Leu His Leu Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Asn Asp Asn Gly Thr Leu Arg Cys Trp Ile 
225                 230                 235                 240 


Gln Val Thr Pro Asn Val Ala Val Lys Tyr Arg Gly Ala Leu Thr His 
                245                 250                 255     


Asn Leu Arg Thr His Val Asp Met Ile Val Met Ala Ala Thr Val Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Val Cys Gly Ala Val Met Ile Val Ser 
        275                 280                 285             


Gln Ala Phe Ile Met Ser Xaa Glu Arg His Asn Phe Thr Gln Glu Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Gln Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Leu Gly Trp Ser Pro Thr Leu Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Ala Arg Val Pro Glu Xaa Val Leu Glu Val Val Phe Gly Gly His 
            340                 345                 350         


Trp Gly Val Val Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Ile Ala Ile Leu Leu Leu Val Ala Gly Val Asp Ala Gly 
    370                 375                 380                 


Thr Tyr Ser Ser Gly Ala Thr Ile Gly Gln Gly Thr Arg Gly Leu Val 
385                 390                 395                 400 


Xaa Leu Phe Ser Ala Gly Pro Ser Gln Lys Ile Ser Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Xaa Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Gln Thr Gly Phe Ile Ala Ser Leu Phe Tyr Ala Lys Ser Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Leu Ser Ser Cys Arg Gly Leu Asp Asp 
    450                 455                 460                 


Phe Arg Ile Gly Trp Gly Thr Leu Glu Tyr Glu Asn Asn Val Thr Asn 
465                 470                 475                 480 


Asp Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys 
                485                 490                 495     


Gly Ile Val Pro Ala Arg Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Lys Gln Gly Val Pro Thr 
        515                 520                 525             


Tyr Ser Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Gln Gly Ala Trp Phe Gly Cys Thr Trp Met Asn Gly Thr 
545                 550                 555                 560 


Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Arg Asp 
                565                 570                 575     


His Thr Ser Thr Leu Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Thr Thr Tyr Leu Lys Cys Gly Ala Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Lys Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Xaa Asn Phe Thr Ile Phe Lys Val Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Phe Ser Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Arg Leu Glu Asp Arg Asp Arg Gly Gln Gln Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Val Leu Pro Cys Ser Phe Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Tyr Leu Tyr Gly Leu Ser Pro Ala Ile Thr Lys Tyr Ile Val Lys Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Ile Leu Gly Gln Ala Glu Ala 
            740                 745                 750 


