                         SEQUENCE LISTING

<110>  Albert-Ludwigs-Universitt Freiburg
 
<120>  Mitochondrial preproteins as markers for Alzheimer's disease

<130>  U 7507-WO / LE

<150>  EP14158408.6
<151>  2014-03-07

<160>  80    

<170>  PatentIn version 3.5

<210>  1
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  1
cgtcaaggag aaaaaacccc ggattctagc atgagatcca gcttgtttaa gggaccacgt       60

g                                                                       61


<210>  2
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  2
cacgtggtcc cttaaacaag ctggatctca tgctagaatc cggggttttt tctccttgac       60

g                                                                       61


<210>  3
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  3
atctgaattc atgtctaaag gtgaagaatt attcac                                 36


<210>  4
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  4
atctgaattc tttgtacaat tcatccatac catg                                   34


<210>  5
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  5
atctgaattc atgtctaaag gtgaagaatt attcac                                 36


<210>  6
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  6
atctgaattc gtttgtacaa ttcatccata ccatg                                  35


<210>  7
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  7
atctactagt atggatgcag aattccgaca tgac                                   34


<210>  8
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  8
atctatcgat ttacgctatg acaacaccgc cc                                     32


<210>  9
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  9
gggcggccgc actagtgaga acctgtactt ccagtccgat gcagaattcc gacatgactc       60

agg                                                                     63


<210>  10
<211>  62
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  10
cggaattctg catcggactg gaagtacagg ttctcactag tgcggccgcc ctttagtgag       60

gg                                                                      62


<210>  11
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  11

Met Leu Ser Ala Leu Ala Arg Pro Ala Ser Ala Ala Leu Arg Arg Ser 
1               5                   10                  15      


Phe Ser Thr Cys 
            20  


<210>  12
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  12

Met Phe Ala Lys Thr Ala Ala Ala Asn Leu Thr Lys Lys Gly Glu Asp 
1               5                   10                  15      


Cys 
    


<210>  13
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  13

Met Leu Ser Leu Arg Gln Ser Ile Arg Phe Phe Lys Pro Ala Thr Arg 
1               5                   10                  15      


Thr Cys 
        


<210>  14
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  14

Cys Gly Lys Asn Phe Ser Ala Gly Gly His Lys Val Gly Leu Gly Phe 
1               5                   10                  15      


Glu Leu Glu Ala 
            20  


<210>  15
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  15

Met Leu Ser Leu Arg Gln Ser Ile Arg Phe Phe Lys Pro Ala Thr Arg 
1               5                   10                  15      


Thr Leu Cys Ser Ser Arg Tyr Leu Leu 
            20                  25  


<210>  16
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  16

Phe Thr Ser Ser Ala Leu Val Arg 
1               5               


<210>  17
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  17

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys 
            20                  25              


<210>  18
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  18

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val 
        35                  40  


<210>  19
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  19

Lys Val Lys Gly Leu Ile Asp Gly Asp His Ile Gly Asp Leu Val Tyr 
1               5                   10                  15      


Glu Phe Met Asp Ser Asn Ser Ala Ile Phe Arg Glu Gly Val Gly Ala 
            20                  25                  30          


Gly His Val His Val Ala Gln Val Glu Phe 
        35                  40          


<210>  20
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  presequence

<400>  20

Met Leu Ser Ala Leu Ala Arg Pro Ala Ser Ala Ala Leu Arg Arg Ser 
1               5                   10                  15      


Phe Ser Thr Ser Ala Gln Asn Asn 
            20                  


<210>  21
<211>  35
<212>  PRT
<213>  artificial

<220>
<223>  presequence

<400>  21

Met Phe Ser Lys Leu Ala His Leu Gln Arg Phe Ala Val Leu Ser Arg 
1               5                   10                  15      


Gly Val His Ser Ser Val Ala Ser Ala Thr Ser Val Ala Thr Lys Lys 
            20                  25                  30          


Thr Val Gln 
        35  


<210>  22
<211>  40
<212>  PRT
<213>  artificial

<220>
<223>  presequence

<400>  22

Met Gln Ala Ala Arg Met Ala Ala Ser Leu Gly Arg Gln Leu Leu Arg 
1               5                   10                  15      


Leu Gly Gly Gly Ser Ser Arg Leu Thr Ala Leu Leu Gly Gln Pro Arg 
            20                  25                  30          


Pro Gly Pro Ala Arg Arg Pro Tyr 
        35                  40  


<210>  23
<211>  33
<212>  PRT
<213>  artificial

<220>
<223>  presequence

<400>  23

Met Ala Ala Val Val Leu Ala Ala Thr Arg Leu Leu Arg Gly Ser Gly 
1               5                   10                  15      


Ser Trp Gly Cys Ser Arg Leu Arg Phe Gly Pro Pro Ala Tyr Arg Arg 
            20                  25                  30          


Phe 
    


<210>  24
<211>  22
<212>  PRT
<213>  artificial

<220>
<223>  presequence

<400>  24

Met Ala Leu Arg Leu Leu Arg Arg Ala Ala Arg Gly Ala Ala Ala Ala 
1               5                   10                  15      


Ala Leu Leu Arg Leu Lys 
            20          


<210>  25
<211>  29
<212>  PRT
<213>  artificial

<220>
<223>  presequence

<400>  25

Met Ser Thr Ala Ala Leu Ile Thr Leu Val Arg Ser Gly Gly Asn Gln 
1               5                   10                  15      


Val Arg Arg Arg Val Leu Leu Ser Ser Arg Leu Leu Gln 
            20                  25                  


<210>  26
<211>  28
<212>  PRT
<213>  artificial

<220>
<223>  presequence

<400>  26

Met Ala Ala Ser Ala Ala Arg Gly Ala Ala Ala Leu Arg Arg Ser Ile 
1               5                   10                  15      


Asn Gln Pro Val Ala Phe Val Arg Arg Ile Pro Trp 
            20                  25              


<210>  27
<211>  23
<212>  PRT
<213>  artificial

<220>
<223>  fragment of presequence

<400>  27

Met Leu Ser Ala Leu Ala Arg Pro Ala Ser Ala Ala Leu Arg Arg Ser 
1               5                   10                  15      


Phe Ser Thr Ser Ala Gln Asn 
            20              


<210>  28
<211>  22
<212>  PRT
<213>  artificial

<220>
<223>  fragment of presequence

<400>  28

Met Leu Ser Ala Leu Ala Arg Pro Ala Ser Ala Ala Leu Arg Arg Ser 
1               5                   10                  15      


Phe Ser Thr Ser Ala Gln 
            20          


<210>  29
<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  fragment of presequence

<400>  29

Met Leu Ser Ala Leu Ala Arg Pro Ala Ser Ala Ala Leu Arg Arg Ser 
1               5                   10                  15      


Phe Ser Thr Ser Ala 
            20      


<210>  30
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  fragment of presequence

<400>  30

Met Leu Ser Ala Leu Ala Arg Pro Ala Ser Ala Ala Leu Arg Arg Ser 
1               5                   10                  15      


Phe Ser Thr Ser 
            20  


<210>  31
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  fragment of presequence

<400>  31

Met Leu Ser Ala Leu Ala Arg Pro Ala Ser Ala Ala Leu Arg Arg Ser 
1               5                   10                  15      


Phe Ser Thr 
            


<210>  32
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  fragment of presequence

<400>  32

Met Leu Ser Ala Leu Ala Arg Pro Ala Ser Ala Ala Leu Arg Arg Ser 
1               5                   10                  15      


Phe Ser 
        


<210>  33
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of presequence

<400>  33

Met Leu Ser Ala Leu Ala Arg Pro Ala Ser Ala Ala Leu Arg Arg Ser 
1               5                   10                  15      


Phe 
    


<210>  34
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of presequence

<400>  34

Met Leu Ser Ala Leu Ala Arg Pro Ala Ser Ala Ala Leu Arg Arg Ser 
1               5                   10                  15      


<210>  35
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of presequence

<400>  35

Met Leu Ser Ala Leu Ala Arg Pro Ala Ser Ala Ala Leu Arg Arg 
1               5                   10                  15  


<210>  36
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of presequence

<400>  36

Met Leu Ser Ala Leu Ala Arg Pro Ala Ser Ala Ala Leu Arg 
1               5                   10                  


<210>  37
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of presequence

<400>  37

Met Leu Ser Ala Leu Ala Arg Pro Ala Ser Ala Ala Leu 
1               5                   10              


<210>  38
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of presequence

<400>  38

Met Leu Ser Ala Leu Ala Arg Pro Ala Ser Ala Ala 
1               5                   10          


<210>  39
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of presequence

<400>  39

Met Phe Ser Lys Leu Ala His Leu Gln Arg Phe Ala Val Leu Ser Arg 
1               5                   10                  15      


Gly Val His Ser Ser Val Ala Ser Ala Thr Ser Val Ala Thr Lys Lys 
            20                  25                  30          


Thr Val 
        


<210>  40
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of presequence

<400>  40

Met Phe Ser Lys Leu Ala His Leu Gln Arg Phe Ala Val Leu Ser Arg 
1               5                   10                  15      


Gly Val His Ser Ser Val Ala Ser Ala Thr Ser Val Ala Thr Lys 
            20                  25                  30      


<210>  41
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of presequence

<400>  41

Met Phe Ser Lys Leu Ala His Leu Gln Arg Phe Ala Val Leu Ser Arg 
1               5                   10                  15      


Gly Val His Ser Ser Val Ala Ser Ala Thr Ser Val 
            20                  25              


<210>  42
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of presequence

<400>  42

Met Phe Ser Lys Leu Ala His Leu Gln Arg Phe Ala Val Leu Ser Arg 
1               5                   10                  15      


Gly Val His Ser Ser Val Ala 
            20              


<210>  43
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of presequence

<400>  43

Met Phe Ser Lys Leu Ala His Leu Gln Arg Phe Ala Val Leu Ser Arg 
1               5                   10                  15      


<210>  44
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of presequence

<400>  44

Met Gln Ala Ala Arg Met Ala Ala Ser Leu Gly Arg Gln Leu Leu Arg 
1               5                   10                  15      


Leu Gly Gly Gly Ser Ser Arg Leu Thr Ala Leu Leu Gly Gln Pro Arg 
            20                  25                  30          


Pro Gly 
        


<210>  45
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of presequence

<400>  45

Met Gln Ala Ala Arg Met Ala Ala Ser Leu Gly Arg Gln Leu Leu Arg 
1               5                   10                  15      


Leu Gly Gly Gly Ser Ser Arg Leu Thr Ala Leu Leu Gly Gln Pro 
            20                  25                  30      


<210>  46
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of presequence

<400>  46

Met Gln Ala Ala Arg Met Ala Ala Ser Leu Gly Arg Gln Leu Leu Arg 
1               5                   10                  15      


Leu Gly Gly Gly Ser Ser Arg Leu Thr Ala Leu Leu 
            20                  25              


<210>  47
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of presequence

<400>  47

Met Gln Ala Ala Arg Met Ala Ala Ser Leu Gly Arg Gln Leu Leu Arg 
1               5                   10                  15      


Leu Gly Gly Gly Ser Ser Arg 
            20              


<210>  48
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of presequence

<400>  48

Met Gln Ala Ala Arg Met Ala Ala Ser Leu Gly Arg Gln Leu 
1               5                   10                  


<210>  49
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of presequence

<400>  49

Met Ala Ala Val Val Leu Ala Ala Thr Arg Leu Leu Arg Gly Ser Gly 
1               5                   10                  15      


Ser Trp Gly Cys Ser Arg Leu Arg Phe Gly Pro 
            20                  25          


<210>  50
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of presequence

<400>  50

Met Ala Ala Val Val Leu Ala Ala Thr Arg Leu Leu Arg Gly Ser Gly 
1               5                   10                  15      


Ser Trp Gly Cys Ser Arg Leu Arg Phe Gly 
            20                  25      


<210>  51
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of presequence

<400>  51

Met Ala Ala Val Val Leu Ala Ala Thr Arg Leu Leu Arg Gly Ser Gly 
1               5                   10                  15      


Ser Trp Gly Cys Ser Arg Leu Arg Phe 
            20                  25  


<210>  52
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of presequence

<400>  52

Met Ala Ala Val Val Leu Ala Ala Thr Arg Leu Leu Arg Gly Ser Gly 
1               5                   10                  15      


Ser Trp Gly Cys Ser Arg Leu Arg 
            20                  


<210>  53
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of presequence

<400>  53

Met Ala Ala Val Val Leu Ala Ala Thr Arg Leu Leu Arg Gly Ser Gly 
1               5                   10                  15      


Ser Trp Gly Cys Ser Arg Leu 
            20              


<210>  54
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of presequence

<400>  54

Met Ala Leu Arg Leu Leu Arg Arg Ala Ala Arg Gly Ala Ala Ala Ala 
1               5                   10                  15      


Ala Leu Leu Arg Leu 
            20      


<210>  55
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of presequence

<400>  55

Met Ala Leu Arg Leu Leu Arg Arg Ala Ala Arg Gly Ala Ala Ala Ala 
1               5                   10                  15      


Ala Leu Leu Arg 
            20  


<210>  56
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of presequence+

<400>  56

Met Ala Leu Arg Leu Leu Arg Arg Ala Ala Arg Gly Ala Ala Ala Ala 
1               5                   10                  15      


Ala Leu Leu 
            


<210>  57
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of presequence

<400>  57

Met Ala Leu Arg Leu Leu Arg Arg Ala Ala Arg Gly Ala Ala Ala Ala 
1               5                   10                  15      


Ala Leu 
        


<210>  58
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of presequence

<400>  58

Met Ala Leu Arg Leu Leu Arg Arg Ala Ala Arg Gly Ala Ala Ala Ala 
1               5                   10                  15      


Ala 
    


<210>  59
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of presequence

<400>  59

Met Ser Thr Ala Ala Leu Ile Thr Leu Val Arg Ser Gly Gly Asn Gln 
1               5                   10                  15      


Val Arg Arg Arg Val Leu Leu Ser Ser Arg 
            20                  25      


<210>  60
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of presequence

<400>  60

Met Ser Thr Ala Ala Leu Ile Thr Leu Val Arg Ser Gly Gly Asn Gln 
1               5                   10                  15      


Val Arg Arg Arg Val Leu Leu Ser 
            20                  


<210>  61
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of presequence

<400>  61

Met Ser Thr Ala Ala Leu Ile Thr Leu Val Arg Ser Gly Gly Asn Gln 
1               5                   10                  15      


Val Arg Arg Arg Val Leu 
            20          


<210>  62
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of presequence

<400>  62

Met Ser Thr Ala Ala Leu Ile Thr Leu Val Arg Ser Gly Gly Asn Gln 
1               5                   10                  15      


Val Arg Arg Arg 
            20  


<210>  63
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of presequence

<400>  63

Met Ser Thr Ala Ala Leu Ile Thr Leu Val Arg Ser Gly Gly Asn Gln 
1               5                   10                  15      


Val Arg Arg 
            


<210>  64
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of presequence

<400>  64

Met Ala Ala Ser Ala Ala Arg Gly Ala Ala Ala Leu Arg Arg Ser Ile 
1               5                   10                  15      


Asn Gln Pro Val Ala Phe Val 
            20              


<210>  65
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of presequence

<400>  65

Met Ala Ala Ser Ala Ala Arg Gly Ala Ala Ala Leu Arg Arg Ser Ile 
1               5                   10                  15      


Asn Gln Pro Val Ala Phe 
            20          


<210>  66
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of presequence

<400>  66

Met Ala Ala Ser Ala Ala Arg Gly Ala Ala Ala Leu Arg Arg Ser Ile 
1               5                   10                  15      


Asn 
    


<210>  67
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of presequence

<400>  67

Met Ala Ala Ser Ala Ala Arg Gly Ala Ala Ala Leu Arg Arg Ser Ile 
1               5                   10                  15      


<210>  68
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of presequence

<400>  68

Met Ala Ala Ser Ala Ala Arg Gly Ala Ala Ala Leu Arg Arg 
1               5                   10                  


<210>  69
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  presequence

<400>  69

Met Ala Ala Ala Ala Gln Ser Arg Val Val Arg Val Leu Ser Met Ser 
1               5                   10                  15      


Arg Ser Ala Ile Thr Ala Ile Ala Thr Ser Val Cys His Gly Pro Pro 
            20                  25                  30          


Cys Arg Gln 
        35  


<210>  70
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  presequence

<400>  70

Met Ala Arg Asn Val Val Tyr Pro Leu Tyr Arg Leu Gly Gly Pro Gln 
1               5                   10                  15      


Leu Arg Val Phe Arg Thr 
            20          


<210>  71
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of presequence

<400>  71

Met Ala Ala Ala Ala Gln Ser Arg Val Val Arg Val Leu Ser Met Ser 
1               5                   10                  15      


Arg Ser Ala Ile Thr Ala Ile Ala Thr Ser Val Cys His 
            20                  25                  


<210>  72
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of presequence

<400>  72

Met Ala Ala Ala Ala Gln Ser Arg Val Val Arg Val Leu Ser Met Ser 
1               5                   10                  15      


Arg Ser Ala Ile Thr Ala Ile Ala 
            20                  


<210>  73
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of presequence

<400>  73

Met Ala Ala Ala Ala Gln Ser Arg Val Val Arg Val Leu Ser Met Ser 
1               5                   10                  15      


Arg Ser Ala Ile 
            20  


<210>  74
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of presequence

<400>  74

Met Ala Ala Ala Ala Gln Ser Arg Val Val Arg Val Leu Ser Met Ser 
1               5                   10                  15      


Arg Ser 
        


<210>  75
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of presequence

<400>  75

Met Ala Ala Ala Ala Gln Ser Arg Val Val Arg Val Leu Ser Met Ser 
1               5                   10                  15      


<210>  76
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of presequence

<400>  76

Met Ala Arg Asn Val Val Tyr Pro Leu Tyr Arg Leu Gly Gly Pro Gln 
1               5                   10                  15      


Leu Arg Val Phe Arg 
            20      


<210>  77
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of presequence

<400>  77

Met Ala Arg Asn Val Val Tyr Pro Leu Tyr Arg Leu Gly Gly Pro Gln 
1               5                   10                  15      


Leu Arg Val Phe 
            20  


<210>  78
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of presequence

<400>  78

Met Ala Arg Asn Val Val Tyr Pro Leu Tyr Arg Leu Gly Gly Pro Gln 
1               5                   10                  15      


Leu Arg Val 
            


<210>  79
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of presequence

<400>  79

Met Ala Arg Asn Val Val Tyr Pro Leu Tyr Arg Leu Gly Gly Pro Gln 
1               5                   10                  15      


Leu Arg 
        


<210>  80
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of presequence

<400>  80

Met Ala Arg Asn Val Val Tyr Pro Leu Tyr Arg Leu Gly Gly Pro Gln 
1               5                   10                  15      


Leu 
    


