                         SEQUENCE LISTING

<110>  The University of North Carolina at Chapel Hill
       Rathmell, W. Kimryn
       Brooks, Samira
       Parker, Joel
       Brannon, A. Rose
 
<120>  METHODS AND COMPOSITIONS FOR PROGNOSTIC RISK ANALYSIS OF CLEAR 
       CELL RENAL CELL CARCINOMA

<130>  421/333 PCT

<150>  US 61/946,160
<151>  2014-02-28

<150>  US 61/952,319
<151>  2014-03-13

<160>  68    

<170>  PatentIn version 3.5

<210>  1
<211>  4903
<212>  DNA
<213>  Homo sapiens

<400>  1
atataggcgg ggtctccccg ccgcaggggc tgggatgctg ggggctgctg aagccgccat       60

cttggattcc gcggtagcgg aggcggcggt caggcgccgc ttctggggag tggcctttct      120

tttcccctcc ctcccggttc ggtggcggcg gctcctccca ctgggggggg gggtggcgcg      180

gcggcggtgg catctgcggc catggcggcg actactgcca accccgaaat gacatcagat      240

gtaccatcac tgggtccagc cattgcctct ggaaactctg gacctggaat tcaaggtgga      300

ggagccattg tccagagggc tattaagcgg cgaccagggc tggattttga tgatgatgga      360

gaagggaaca gtaaattttt gaggtgtgat gatgatcaga tgtctaacga taaggagcgg      420

tttgccaggt cggatgatga gcagagctct gcggataaag agagacttgc cagggaaaat      480

cacagtgaaa ttgaacggcg gcgacggaac aagatgacag cctacatcac agaactgtca      540

gatatggtac ccacctgtag tgccctggct cgaaaaccag acaagctaac catcttacgc      600

atggcagttt ctcacatgaa gtccttgcgg ggaactggca acacatccac tgatggctcc      660

tataagccgt ctttcctcac tgatcaggaa ctgaaacatt tgatcttgga ggcagcagat      720

ggctttctgt ttattgtctc atgtgagaca ggcagggtgg tgtatgtgtc tgactccgtg      780

actcctgttt tgaaccagcc acagtctgaa tggtttggca gcacactcta tgatcaggtg      840

cacccagatg atgtggataa acttcgtgag cagctttcca cttcagaaaa tgccctgaca      900

gggcgtatcc tggatctaaa gactggaaca gtgaaaaagg aaggtcagca gtcttccatg      960

agaatgtgta tgggctcaag gagatcgttt atttgccgaa tgaggtgtgg cagtagctct     1020

gtggacccag tttctgtgaa taggctgagc tttgtgagga acagatgcag gaatggactt     1080

ggctctgtaa aggatgggga acctcacttc gtggtggtcc actgcacagg ctacatcaag     1140

gcctggcccc cagcaggtgt ttccctccca gatgatgacc cagaggctgg ccagggaagc     1200

aagttttgcc tagtggccat tggcagattg caggtaacta gttctcccaa ctgtacagac     1260

atgagtaatg tttgtcaacc aacagagttc atctcccgac acaacattga gggtatcttc     1320

acttttgtgg atcaccgctg tgtggctact gttggctacc agccacagga actcttagga     1380

aagaatattg tagaattctg tcatcctgaa gaccagcagc ttctaagaga cagcttccaa     1440

caggtagtga aattaaaagg ccaagtgctg tctgtcatgt tccggttccg gtctaagaac     1500

caagaatggc tctggatgag aaccagctcc tttactttcc agaaccctta ctcagatgaa     1560

attgagtaca tcatctgtac caacaccaat gtgaagaact ctagccaaga accacggcct     1620

acactctcca acacaatcca gaggccacaa ctaggtccca cagctaattt acccctggag     1680

atgggctcag gacagctggc acccaggcag cagcaacagc aaacagaatt ggacatggta     1740

ccaggaagag atggactggc cagctacaat cattcccagg tggttcagcc tgtgacaacc     1800

acaggaccag aacacagcaa gccccttgag aagtcagatg gtttatttgc ccaggataga     1860

gatccaagat tttcagaaat ctatcacaac atcaatgcgg atcagagtaa aggcatctcc     1920

tccagcactg tccctgccac ccaacagcta ttctcccagg gcaacacatt ccctcctacc     1980

ccccggccgg cagagaattt caggaatagt ggcctagccc ctcctgtaac cattgtccag     2040

ccatcagctt ctgcaggaca gatgttggcc cagatttccc gccactccaa ccccacccaa     2100

ggagcaaccc caacttggac ccctactacc cgctcaggct tttctgccca gcaggtggct     2160

acccaggcta ctgctaagac tcgtacttcc cagtttggtg tgggcagctt tcagactcca     2220

tcctccttca gctccatgtc cctccctggt gccccaactg catcgcctgg tgctgctgcc     2280

taccctagtc tcaccaatcg tggatctaac tttgctcctg agactggaca gactgcagga     2340

caattccaga cacggacagc agagggtgtg ggtgtctggc cacagtggca gggccagcag     2400

cctcatcatc gttcaagttc tagtgagcaa catgttcaac aaccgccagc acagcaacct     2460

ggccagcctg aggtcttcca ggagatgctg tccatgctgg gagatcagag caacagctac     2520

aacaatgaag aattccctga tctaactatg tttcccccct tttcagaata gaactattgg     2580

ggtgaggata aggggtgggg gagaaaaaat cactgtttgt ttttaaaaag caaatctttc     2640

tgtaaacaga ataaaagttc ctctcccttc ccttccctca cccctgacat gtaccccctt     2700

tcccttctgg ctgttcccct gctctgttgc ctctctaagg taacatttat agaagaaatg     2760

gaatgaatct ccaaggcttt taggactgtc tgaaaatttg aggctgggtg aagttaaaac     2820

acctttcctt atgtctcctg acctgaaatt gtatagtgtt gatttgtgct gagatcaaga     2880

ggcaggttag aagaacctga catccactgt ttgccttgga tagtatggct tgtttttgga     2940

aagaaattct gaagagagtg gaggagagga gaaatgtcct catatttgag gaccatgaaa     3000

cattgtaggt atatatgggg ctttagcaag tttgagcata ggctcttttt gctgcctgtg     3060

agcagtccct ctggaaagaa acatgtgagt aagtgagaga gagtgtgtgt gtatgtgtgt     3120

gtgtgtgtgt gtgcgcacac atgcttctgt atttcactct ttctccctat tagggagtta     3180

tgcaaaattt gtccccgatt ttacctttgt ctttctgtgt acttttcaaa gagtcctaag     3240

gagttaaatc ttccaggtat tttccactta gtattgcagc caaagaatat ttaaataaac     3300

gtctttgctg cgcttgcatc catgcccagc caatatacaa ctgtaaagca aatatagaaa     3360

gtcggctgtt gatacgattg tctgttatcg aacacattca gtgataaagc tgggttactg     3420

ctgcttttgg tgctctcacc ttatctggaa gatctgcaaa cattacctaa ataggctggc     3480

aagataaaca ctttctggaa cccgagactt ggccataaag ataatgctgc atttttctgt     3540

cagaatcaca tatgatgtgt gttctgtaga ggttatttct gcatggaaac tcaacttctt     3600

ggattagccg tcccagtgaa aatcctcatt gttggagtgt aaaccaaata cgaagccctc     3660

ttgcaaagta gcctctttca tcccatactc aaaataccca gtttagcaag caactgagat     3720

ttaagtctct ctggccctaa gaggtttttc ctctttgctc cctccaatct tgagattggg     3780

ttttgcttta gagtgcaagt atcataattc cgtatgatag atggggcctg gacacccatc     3840

tcaacagggt cacttggtaa ttaacaatag ccatataaat gcggatacag gttactaccc     3900

tcacccttta ccttcctcag gtaacagtcg tagataccag cttttttttt ttttttttta     3960

aattggcttt ggccagtagc taaagtgcaa gactgaatta atgagaagat atattaaatg     4020

tagtcatagg ggactgagga gcaagggtgg ccttgaagag gccaaaggaa tgtccatttg     4080

ctgagtttcc cttccttatg tctccagtct ggtgccaggt agtggagtaa aaaaggagac     4140

agtttatttt tttattctat gtgcacactt acagtataca tatatattta tatcacaatt     4200

tacgaaacca aaaagttgag tttccaatgg aacccttgtt ttttaataat cgacttttta     4260

aatgtgatca ggactataat attgtacagt tattataggg cttttgggga aggggaggat     4320

agcgagaaga tgctctgggg gttttgtttt tgcttttcct tcagggtttt atttttgact     4380

gttttgtttt cttgttggcc atttctgtat tgctggcatc tgtgctaagc tttacagtgg     4440

caaaaataat gacatgtagc aaagattttc aaacaaaata ttttttcctt ttgtaaaatt     4500

tcttgtgttg tgtgatcttg attgcggctt tatcattcct ttccagttca taaacaacag     4560

gcacccacaa ccagaggaat ctatagttta agctccagac atacaaacat aaggcacatt     4620

gtgtctttaa tttcaggaat cagaaatcat agggttctga tcacattgca cgcctccccc     4680

ctcacttgtc ctcctgatcc tgacacattc tgagtaacat cagcaggaat gctctgacca     4740

tgaggtgggg gttttggggt gggcgttgcc tgggttcttg ggagagaggg gaagagtcgg     4800

gacttgaaaa ccactagggc acatctggat gccttccccc agtatgtcct tttctggatt     4860

aaaatgagtg aaatttaaac tgttcaaaaa aaaaaaaaaa aaa                       4903


<210>  2
<211>  789
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Ala Thr Thr Ala Asn Pro Glu Met Thr Ser Asp Val Pro Ser 
1               5                   10                  15      


Leu Gly Pro Ala Ile Ala Ser Gly Asn Ser Gly Pro Gly Ile Gln Gly 
            20                  25                  30          


Gly Gly Ala Ile Val Gln Arg Ala Ile Lys Arg Arg Pro Gly Leu Asp 
        35                  40                  45              


Phe Asp Asp Asp Gly Glu Gly Asn Ser Lys Phe Leu Arg Cys Asp Asp 
    50                  55                  60                  


Asp Gln Met Ser Asn Asp Lys Glu Arg Phe Ala Arg Ser Asp Asp Glu 
65                  70                  75                  80  


Gln Ser Ser Ala Asp Lys Glu Arg Leu Ala Arg Glu Asn His Ser Glu 
                85                  90                  95      


Ile Glu Arg Arg Arg Arg Asn Lys Met Thr Ala Tyr Ile Thr Glu Leu 
            100                 105                 110         


Ser Asp Met Val Pro Thr Cys Ser Ala Leu Ala Arg Lys Pro Asp Lys 
        115                 120                 125             


Leu Thr Ile Leu Arg Met Ala Val Ser His Met Lys Ser Leu Arg Gly 
    130                 135                 140                 


Thr Gly Asn Thr Ser Thr Asp Gly Ser Tyr Lys Pro Ser Phe Leu Thr 
145                 150                 155                 160 


Asp Gln Glu Leu Lys His Leu Ile Leu Glu Ala Ala Asp Gly Phe Leu 
                165                 170                 175     


Phe Ile Val Ser Cys Glu Thr Gly Arg Val Val Tyr Val Ser Asp Ser 
            180                 185                 190         


Val Thr Pro Val Leu Asn Gln Pro Gln Ser Glu Trp Phe Gly Ser Thr 
        195                 200                 205             


Leu Tyr Asp Gln Val His Pro Asp Asp Val Asp Lys Leu Arg Glu Gln 
    210                 215                 220                 


Leu Ser Thr Ser Glu Asn Ala Leu Thr Gly Arg Ile Leu Asp Leu Lys 
225                 230                 235                 240 


Thr Gly Thr Val Lys Lys Glu Gly Gln Gln Ser Ser Met Arg Met Cys 
                245                 250                 255     


Met Gly Ser Arg Arg Ser Phe Ile Cys Arg Met Arg Cys Gly Ser Ser 
            260                 265                 270         


Ser Val Asp Pro Val Ser Val Asn Arg Leu Ser Phe Val Arg Asn Arg 
        275                 280                 285             


Cys Arg Asn Gly Leu Gly Ser Val Lys Asp Gly Glu Pro His Phe Val 
    290                 295                 300                 


Val Val His Cys Thr Gly Tyr Ile Lys Ala Trp Pro Pro Ala Gly Val 
305                 310                 315                 320 


Ser Leu Pro Asp Asp Asp Pro Glu Ala Gly Gln Gly Ser Lys Phe Cys 
                325                 330                 335     


Leu Val Ala Ile Gly Arg Leu Gln Val Thr Ser Ser Pro Asn Cys Thr 
            340                 345                 350         


Asp Met Ser Asn Val Cys Gln Pro Thr Glu Phe Ile Ser Arg His Asn 
        355                 360                 365             


Ile Glu Gly Ile Phe Thr Phe Val Asp His Arg Cys Val Ala Thr Val 
    370                 375                 380                 


Gly Tyr Gln Pro Gln Glu Leu Leu Gly Lys Asn Ile Val Glu Phe Cys 
385                 390                 395                 400 


His Pro Glu Asp Gln Gln Leu Leu Arg Asp Ser Phe Gln Gln Val Val 
                405                 410                 415     


Lys Leu Lys Gly Gln Val Leu Ser Val Met Phe Arg Phe Arg Ser Lys 
            420                 425                 430         


Asn Gln Glu Trp Leu Trp Met Arg Thr Ser Ser Phe Thr Phe Gln Asn 
        435                 440                 445             


Pro Tyr Ser Asp Glu Ile Glu Tyr Ile Ile Cys Thr Asn Thr Asn Val 
    450                 455                 460                 


Lys Asn Ser Ser Gln Glu Pro Arg Pro Thr Leu Ser Asn Thr Ile Gln 
465                 470                 475                 480 


Arg Pro Gln Leu Gly Pro Thr Ala Asn Leu Pro Leu Glu Met Gly Ser 
                485                 490                 495     


Gly Gln Leu Ala Pro Arg Gln Gln Gln Gln Gln Thr Glu Leu Asp Met 
            500                 505                 510         


Val Pro Gly Arg Asp Gly Leu Ala Ser Tyr Asn His Ser Gln Val Val 
        515                 520                 525             


Gln Pro Val Thr Thr Thr Gly Pro Glu His Ser Lys Pro Leu Glu Lys 
    530                 535                 540                 


Ser Asp Gly Leu Phe Ala Gln Asp Arg Asp Pro Arg Phe Ser Glu Ile 
545                 550                 555                 560 


Tyr His Asn Ile Asn Ala Asp Gln Ser Lys Gly Ile Ser Ser Ser Thr 
                565                 570                 575     


Val Pro Ala Thr Gln Gln Leu Phe Ser Gln Gly Asn Thr Phe Pro Pro 
            580                 585                 590         


Thr Pro Arg Pro Ala Glu Asn Phe Arg Asn Ser Gly Leu Ala Pro Pro 
        595                 600                 605             


Val Thr Ile Val Gln Pro Ser Ala Ser Ala Gly Gln Met Leu Ala Gln 
    610                 615                 620                 


Ile Ser Arg His Ser Asn Pro Thr Gln Gly Ala Thr Pro Thr Trp Thr 
625                 630                 635                 640 


Pro Thr Thr Arg Ser Gly Phe Ser Ala Gln Gln Val Ala Thr Gln Ala 
                645                 650                 655     


Thr Ala Lys Thr Arg Thr Ser Gln Phe Gly Val Gly Ser Phe Gln Thr 
            660                 665                 670         


Pro Ser Ser Phe Ser Ser Met Ser Leu Pro Gly Ala Pro Thr Ala Ser 
        675                 680                 685             


Pro Gly Ala Ala Ala Tyr Pro Ser Leu Thr Asn Arg Gly Ser Asn Phe 
    690                 695                 700                 


Ala Pro Glu Thr Gly Gln Thr Ala Gly Gln Phe Gln Thr Arg Thr Ala 
705                 710                 715                 720 


Glu Gly Val Gly Val Trp Pro Gln Trp Gln Gly Gln Gln Pro His His 
                725                 730                 735     


Arg Ser Ser Ser Ser Glu Gln His Val Gln Gln Pro Pro Ala Gln Gln 
            740                 745                 750         


Pro Gly Gln Pro Glu Val Phe Gln Glu Met Leu Ser Met Leu Gly Asp 
        755                 760                 765             


Gln Ser Asn Ser Tyr Asn Asn Glu Glu Phe Pro Asp Leu Thr Met Phe 
    770                 775                 780                 


Pro Pro Phe Ser Glu 
785                 


<210>  3
<211>  3505
<212>  DNA
<213>  Homo sapiens

<400>  3
cgtcaggggc aggggaggga cggcgcaggc gcagaaaagg gggcggcgga ctcggcttgt       60

tgtgttgctg cctgagtgcc ggagacggtc ctgctgctgc cgcagtcctg ccagctgtcc      120

gacaatgtcg tcccacctag tcgagccgcc gccgcccctg cacaacaaca acaacaactg      180

cgaggaaaat gagcagtctc tgcccccgcc ggccggcctc aacagttcct gggtggagct      240

acccatgaac agcagcaatg gcaatgataa tggcaatggg aaaaatgggg ggctggaaca      300

cgtaccatcc tcatcctcca tccacaatgg agacatggag aagattcttt tggatgcaca      360

acatgaatca ggacagagta gttccagagg cagttctcac tgtgacagcc cttcgccaca      420

agaagatggg cagatcatgt ttgatgtgga aatgcacacc agcagggacc atagctctca      480

gtcagaagaa gaagttgtag aaggagagaa ggaagtcgag gctttgaaga aaagtgcgga      540

ctgggtatca gactggtcca gtagacccga aaacattcca cccaaggagt tccacttcag      600

acaccctaaa cgttctgtgt ctttaagcat gaggaaaagt ggagccatga agaaaggggg      660

tattttctcc gcagaatttc tgaaggtgtt cattccatct ctcttccttt ctcatgtttt      720

ggctttgggg ctaggcatct atattggaaa gcgactgagc acaccctctg ccagcaccta      780

ctgagggaaa ggaaaagccc ctggaaatgc gtgtgacctg tgaagtggtg tattgtcaca      840

gtagcttatt tgaacttgag accattgtaa gcatgaccca acctaccacc ctgtttttac      900

atatccaatt ccagtaactc tcaaattcaa tattttattc aaactctgtt gaggcatttt      960

actaacctta tacccttttt ggcctgaaga cattttagaa tttcctaaca gagtttactg     1020

ttgtttagaa atttgcaagg gcttcttttc cgcaaatgcc accagcagat tataattttg     1080

tcagcaatgc tattatctct aattagtgcc accagactag acctgtatca ttcatggtat     1140

aaattttact cttgcaacat aactaccatc tctctcttaa aacgagatca ggttagcaaa     1200

tgatgtaaaa gaagctttat tgtctagttg ttttttttcc cccaagacaa aggcaagttt     1260

ccctaagttt gagttgatag ttattaaaaa gaaaacaaaa caaaaaaaaa aggcaaggca     1320

caacaaaaaa atatcctggg caataaaaaa aatattttaa accagctttg gagccacttt     1380

tttgtctaag cctcctaata gcgtctttta atttatagga ggcaaactgt ataaatgata     1440

ggtatgaaat agaataagaa gtaaaataca tcagcagatt ttcatactag tatgttgtaa     1500

tgctgtcttt tctatggtgt agaatctttc tttctgataa ggaacgtctc aggcttagaa     1560

atatatgaaa ttgctttttg agatttttgc gtgtgtgttt gatatttttt acgataatta     1620

gctgcatgtg aatttttcat gaccttcttt acatttttta ttttttattt ctttattttt     1680

ttttctctaa gaagaggctt tggaatgagt tccaatttgt gatgttaata caggcttctt     1740

gttttaggaa gcatcaccta tactctgaag cctttaaact ctgaagagaa ttgtttcaga     1800

gttattccaa gcacttgtgc aacttggaaa aacagacttg ggttgtggga acagttgaca     1860

gcgttctgaa aagatgccat ttgtttcctt ctgatctctc actgaataat gtttactgta     1920

cagtcttccc aaggtgattc ctgcgactgc aggcactggt cattttctca tgtagctgtc     1980

ttttcagtta tggtaaactc ttaaagttca gaacactcaa cagattcctt cagtgatata     2040

cttgttcgtt catttctaaa atgtgaagct ttaggaccaa attgttagaa agcatcagga     2100

tgaccagtta tctcgagtag attttcttgg atttcagaac atctagcatg actctgaagg     2160

ataccacatg ttttatatat aaataattac tgtttatgat atagacattg atattgacta     2220

tttagagaac cgttgttaat tttaaaacta gcaatctata aagtgcacca ggtcaacttg     2280

aataaaaaca ctatgacaga caggtttgcc agtttgcaga aactaactct tttctcacat     2340

caacatttgt aaaattgatg tgttatagtg gaaaataaca tatagattaa acaaaatttt     2400

tatctttttt caagaatata gctggctatc tttaagaaag atgatatatc ctagttttga     2460

aagtaatttt cttttttctt tctagcattt gatgtctaaa taattttgga catctttttc     2520

ctagaccatg tttctgtctt actcttaaac ctggtaacac ttgatttgcc ttctataacc     2580

tatttatttc aagtgttcat atttgaattt ctttgggaag aaagtaaatc tgatggctca     2640

ctgatttttg aaaagcctga ataaaattgg aaagactgga aagttaggag aactgactag     2700

ctaaactgct acagtatgca atttctatta caattggtat tacagggggg aaaagtaaaa     2760

ttacacttta cctgaaagtg acttcttaca gctagtgcat tgtgctcttt ccaagttcag     2820

cagcagttct atcagtggtg ccactgaaac tgggtatatt tatgatttct ttcagcgtta     2880

aaaagaaaca tagtgttgcc ctttttctta aagcatcagt gaaattatgg aaaattactt     2940

aaaacgtgaa tacatcatca cagtagaatt tattatgaga gcatgtagta tgtatctgta     3000

gccctaacac atgggatgaa cgttttactg ctacacccag atttgtgttg aacgaaaaca     3060

ttgtggtttg gaaaggagaa ttcaacaatt aatagttgaa attgtgaggt taatgtttaa     3120

aaagctttac acctgtttac aatttgggga caaaaaggca ggcttcattt ttcatatgtt     3180

tgatgaaaac tggctcaaga tgtttgtaaa tagaatcaag agcaaaactg cacaaacttg     3240

cacattggaa agtgcaacaa gttcccgtga ttgcagtaaa aatatttact attctaaaaa     3300

aatgagaatt gaagacttag ccagtcagat aagttttttc atgaacccgt tgtggaaatt     3360

attggaatta actgagccaa agtgattatg cattcttcat ctattttagt tagcactttg     3420

tatcgttata tacagtttac aatacatgta taacttgtag ctataaacat tttgtgccat     3480

taaagctctc acaaaacttt aaaaa                                           3505


<210>  4
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ser Ser His Leu Val Glu Pro Pro Pro Pro Leu His Asn Asn Asn 
1               5                   10                  15      


Asn Asn Cys Glu Glu Asn Glu Gln Ser Leu Pro Pro Pro Ala Gly Leu 
            20                  25                  30          


Asn Ser Ser Trp Val Glu Leu Pro Met Asn Ser Ser Asn Gly Asn Asp 
        35                  40                  45              


Asn Gly Asn Gly Lys Asn Gly Gly Leu Glu His Val Pro Ser Ser Ser 
    50                  55                  60                  


Ser Ile His Asn Gly Asp Met Glu Lys Ile Leu Leu Asp Ala Gln His 
65                  70                  75                  80  


Glu Ser Gly Gln Ser Ser Ser Arg Gly Ser Ser His Cys Asp Ser Pro 
                85                  90                  95      


Ser Pro Gln Glu Asp Gly Gln Ile Met Phe Asp Val Glu Met His Thr 
            100                 105                 110         


Ser Arg Asp His Ser Ser Gln Ser Glu Glu Glu Val Val Glu Gly Glu 
        115                 120                 125             


Lys Glu Val Glu Ala Leu Lys Lys Ser Ala Asp Trp Val Ser Asp Trp 
    130                 135                 140                 


Ser Ser Arg Pro Glu Asn Ile Pro Pro Lys Glu Phe His Phe Arg His 
145                 150                 155                 160 


Pro Lys Arg Ser Val Ser Leu Ser Met Arg Lys Ser Gly Ala Met Lys 
                165                 170                 175     


Lys Gly Gly Ile Phe Ser Ala Glu Phe Leu Lys Val Phe Ile Pro Ser 
            180                 185                 190         


Leu Phe Leu Ser His Val Leu Ala Leu Gly Leu Gly Ile Tyr Ile Gly 
        195                 200                 205             


Lys Arg Leu Ser Thr Pro Ser Ala Ser Thr Tyr 
    210                 215                 


<210>  5
<211>  984
<212>  DNA
<213>  Homo sapiens

<400>  5
actagttgat gacgcaccca tggcgcctgg ttgtctagac gagccggtgt accgactccc       60

cggtggatga taactatgag tgcaaaagca agacgcgcac tttcctgtca cctcgccctt      120

tcaccccctc gggaagatca aagtgtcttt agcccaagca tggccttgag cgacttcatc      180

acacctgcat gaggtcacaa gcagtcacta gcgcaggggg gtgaggcgag ttctgggtga      240

aagaaacggg gcggggctga ggccaaggaa gaggttggac tgtgtctcgc atgctcctga      300

cgcagaaggt tttgaacctt ttttcacctc gtctgaaatg gctgcctccc agtgtctctg      360

ctgctcaaaa tttctcttcc agagacagaa cctcgcctgt ttcctcacaa acccacactg      420

tggcagcctt gttaatgcag atggccatgg tgaagtgtgg acagattgga ataatatgtc      480

caagtttttc cagtatggat ggcgatgcac cactaatgag aatacctatt caaaccgtac      540

cctgatgggc aactggaacc aggaaagata tgacctgagg aatatcgtgc agcccaaacc      600

cttgccttcc cagtttggac actactttga aacaacatat gatacaagct acaacaacaa      660

aatgccactt tcaacacata gatttaagcg agagcctcac tggttcccag gacatcaacc      720

tgaactggat cctccccgat acaaatgcac agaaaagtca acttacatga atagctattc      780

aaagccttaa attgggcatc actcaggatg tgtataagat cttaatattg actagtttca      840

catccaggtt tctaagaaat gataagatac ttcacttttc cagagtgaaa tgtaggaggg      900

agcacattct aagtacagct aaaaatttag ctcactgtaa cacagtttca ctctctgaat      960

aaataaagca aaaaacacag taaa                                             984


<210>  6
<211>  150
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Ala Ser Gln Cys Leu Cys Cys Ser Lys Phe Leu Phe Gln Arg 
1               5                   10                  15      


Gln Asn Leu Ala Cys Phe Leu Thr Asn Pro His Cys Gly Ser Leu Val 
            20                  25                  30          


Asn Ala Asp Gly His Gly Glu Val Trp Thr Asp Trp Asn Asn Met Ser 
        35                  40                  45              


Lys Phe Phe Gln Tyr Gly Trp Arg Cys Thr Thr Asn Glu Asn Thr Tyr 
    50                  55                  60                  


Ser Asn Arg Thr Leu Met Gly Asn Trp Asn Gln Glu Arg Tyr Asp Leu 
65                  70                  75                  80  


Arg Asn Ile Val Gln Pro Lys Pro Leu Pro Ser Gln Phe Gly His Tyr 
                85                  90                  95      


Phe Glu Thr Thr Tyr Asp Thr Ser Tyr Asn Asn Lys Met Pro Leu Ser 
            100                 105                 110         


Thr His Arg Phe Lys Arg Glu Pro His Trp Phe Pro Gly His Gln Pro 
        115                 120                 125             


Glu Leu Asp Pro Pro Arg Tyr Lys Cys Thr Glu Lys Ser Thr Tyr Met 
    130                 135                 140                 


Asn Ser Tyr Ser Lys Pro 
145                 150 


<210>  7
<211>  3220
<212>  DNA
<213>  Homo sapiens

<400>  7
cacgaggccg tctccccggc ccagcccggc cgctcgccct gtccggtctc tccccggccc       60

cttgattctc cgcgtcttcc tcgcaggcca gcctaagctc agcctgcatt gcgccctccc      120

ggcctagggt gtcgctgtac cggcctccga gctccacata gacaagtccg gacctcgggc      180

gggggcagga gacggagctg agcggcgggg ggcagtgtcg cctcggtcta gggacggcgg      240

cggagtcggt ggtccctgcg cgatggccac ctcggtgttg tgctgcctgc ggtgctgcag      300

agacgggggg actggccaca tccctctgaa ggagatgccg gccgtgcagc tggacacgca      360

gcacatggga acagatgttg ttattgtaaa gaatggaaga agaatatgtg gaacaggagg      420

ttgtttagcc agcgcacctt tacatcaaaa caaaagctat tttgaattca aaatccagtc      480

cacaggaatc tggggtattg gtgttgcaac tcagaaggtt aacttgaatc agattcctct      540

tggccgagat atgcacagtc tggtgatgag aaatgatgga gccctttacc acaacaatga      600

agagaaaaat aggctgccag caaacagtct tccgcaggaa ggagatgtgg tgggtattac      660

ttatgaccat gtcgaattaa atgtatactt gaatggaaaa aacatgcatt gtccagcatc      720

aggtatacga gggacagtgt atccagttgt ttatgttgat gacagtgcaa ttttggattg      780

ccagttcagt gagttttatc atacgcctcc acctggtttt gaaaaaatat tatttgaaca      840

gcaaatcttc tgaatgtatt tgtttttaaa acttgtattt ctgcactgtt aaaaaatgtt      900

catcatttaa taaaacttta cctggcctat agatgaaaat atattcttaa aaatatgctt      960

gttgatgctg tctaaggaac caatgtattc agtataccac cctgaagttg tgatttaaaa     1020

tactttatgt tttgtgaaat gaaaataagc atttgggcag tttatttaat tcttatttaa     1080

ataaatagaa ttatgggttt aattaacagt ataacatgac tatatataca tatatattta     1140

aagggaattc tttcttacat aatatatttg ttttgataga gatgtagagt tgggtgggtg     1200

tttttgtcac tctgaagttt agacctcatt aaatatttga catctacagt tggataattt     1260

tgccgcttag tgtccttttt tatatacaat ataacaaagt gagagaaatt tatattactg     1320

gcaatttcat ttttggcagt ctatttctgt atcatgtacc gcttttctta aaacttaaat     1380

tgcttatttt gttgtgtaat gtcattgctt ttgatttgct ttgtgaaagg agataaacgt     1440

ttcagtaatt gtcagagcat tttgttgcct caggctgtgt tacctcaatt tcagagtaag     1500

tagtggttga ttagtaatgt agtatacact ggcagacatc tagaatagta tgatgcttta     1560

catttaaatg aggttattct tttaaggact tttatttgta tgttttctgt aaggaataat     1620

aaaataattg taattaagga atataccata ctatattaaa cacattcttc ctattttgtt     1680

agttatacac taaattcaca tcacccgtga ttatttcagt tcagagataa gtgaatcctc     1740

ttcatgaccc tgagtctttg cctggttctt aagaatcact gtcctttagt taacgccctg     1800

tgacctgaac caatcactct atacatcttt agatacgttg tctgttttca aatgagcatg     1860

gcaaggatgc atacatttcc ctcctttatc aactagaaac agtacattgt tcaggaaaac     1920

atgagtgtta gaattagaaa gagatccaaa ttgtagtttt gctgctcatc ctattttctc     1980

ctctccaagt ctcagattcc catttataaa aggagcaatc atactgacat aagattctat     2040

gattaaataa ggtaatacat atataacacc ttaataatca taggcacttg cgccaggcgc     2100

ggtggctcac acctgtaatc ccagcacttt gggaggctga ggcgggagga tcacaaggtc     2160

aggagatcga gaccatcgtg gctaacatgg tgaaaccctg gctctactaa aaaaatacaa     2220

aaaaaattag ccaggtgtgg tggcgggcgc ctgtagttct agctactctg gaggctgagg     2280

caggagaatg gcttgaaccc gggagacggc gcttgcagtg agccgagatt gccccactgc     2340

actccagcct aggcaacaga gtgagactct gtctcaaaaa aaattaaaat aaaataaaat     2400

aaaaatcata ggcacttagt aagtgtagtt tcctggatgg taaagtatca gggaaagtgg     2460

ttttctttct tttttttttt ttctcgtttt ttttttgaga cagagtctca ccttgtcacc     2520

caggctagag tgcagtggca cgatcttggc tcactgcaac ctctgcttcc caggtttaag     2580

cgattctctt gcctcagcct cccgagtagg tgggactaca ggtgcccgcc accacgcccg     2640

tgtaattttt gtatttttag tagagatggg gtttcaccat gttgtccagg ctggtctcaa     2700

actcctgacc tcatgatcca cctccctcag cctcccaaag tgctggaatt ataggcgtaa     2760

gccaccacac ccagccagaa agtggttctc atgatgcttc tcagaccggc aacatcagca     2820

tcactggaac ttgttaaaaa tggacactct cagaacccac accagaccca ccaaatcagt     2880

ttgagaactg ccattcagta gagaattatt tgcctactgt aaattttcta aggatttatg     2940

atgggctatt tttgacccat aggctcagag aatcctgcaa aatccttttt tattgtttat     3000

tctgcagaca aaaatgtgac aatatgcttt gaaaacatag atatacttga gtaacattta     3060

tttacataaa tcccaaattc tacctctgaa ggtatatgaa atttaactat gtatgtatta     3120

tgcattttgt ctggctttct atcataattt taatttgtaa agaatgtgct tacttgggaa     3180

agcaaattaa agtgactact gtttgctatc aaaaaaaaaa                           3220


<210>  8
<211>  196
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Thr Ser Val Leu Cys Cys Leu Arg Cys Cys Arg Asp Gly Gly 
1               5                   10                  15      


Thr Gly His Ile Pro Leu Lys Glu Met Pro Ala Val Gln Leu Asp Thr 
            20                  25                  30          


Gln His Met Gly Thr Asp Val Val Ile Val Lys Asn Gly Arg Arg Ile 
        35                  40                  45              


Cys Gly Thr Gly Gly Cys Leu Ala Ser Ala Pro Leu His Gln Asn Lys 
    50                  55                  60                  


Ser Tyr Phe Glu Phe Lys Ile Gln Ser Thr Gly Ile Trp Gly Ile Gly 
65                  70                  75                  80  


Val Ala Thr Gln Lys Val Asn Leu Asn Gln Ile Pro Leu Gly Arg Asp 
                85                  90                  95      


Met His Ser Leu Val Met Arg Asn Asp Gly Ala Leu Tyr His Asn Asn 
            100                 105                 110         


Glu Glu Lys Asn Arg Leu Pro Ala Asn Ser Leu Pro Gln Glu Gly Asp 
        115                 120                 125             


Val Val Gly Ile Thr Tyr Asp His Val Glu Leu Asn Val Tyr Leu Asn 
    130                 135                 140                 


Gly Lys Asn Met His Cys Pro Ala Ser Gly Ile Arg Gly Thr Val Tyr 
145                 150                 155                 160 


Pro Val Val Tyr Val Asp Asp Ser Ala Ile Leu Asp Cys Gln Phe Ser 
                165                 170                 175     


Glu Phe Tyr His Thr Pro Pro Pro Gly Phe Glu Lys Ile Leu Phe Glu 
            180                 185                 190         


Gln Gln Ile Phe 
        195     


<210>  9
<211>  1448
<212>  DNA
<213>  Homo sapiens

<400>  9
agtgagaggc cgggggtgtg gtagagagaa ggagccggcc gggtacttag gaccgcgcca       60

gcctctgagc ccggcctcct tcgcactttc gagtgcgcgt ttgctgcccg ccgcagcccg      120

ggcgttgaag gtagtaaagc ggccacccgg ccgcatcatg gtgaccccct gtcccaccag      180

cccctcgagc cccgccgccc gagcggggag gcgggacaac gaccagaacc ttcgcgcccc      240

ggtgaagaag agcaggcgtc cgcgcctccg gaggaagcag ccgctgcatc ccctgaaccc      300

gtgcccgctc ccgggagact ccggcatttg cgacctgttc gagtccccca gctccggctc      360

agacggcgca gagagcccct ctgcggcgcg gggtggtagc cccctgcccg gcccggccca      420

gcccgtggcg cagctagatc tacagacctt ccgcgactac ggccagagct gctacgcctt      480

ccgcaaggcg caggagagcc acttccaccc gcgggaggcg ctggcacggc agccacaagt      540

gacggcggaa tcccgctgta agctgctcag ctggctgatc ccggtgcacc gccaattcgg      600

cctctccttc gagtcgctgt gcctgacggt gaacactctg gaccgcttcc tcaccaccac      660

gccggtggct gcagactgct tccagctgct tggggtcacc tccttgctca tcgcttgcaa      720

acaggtggag gtgcacccgc cgcgcgtgaa gcagcttctg gccctctgct gcggcgcctt      780

ctcccggcag cagctctgca acctcgagtg catcgtgctg cacaagctgc acttcaccct      840

gggtgcgccc accattagct tcttcctgga gcatttcacg cacgctcgcg tggaggcggg      900

gcaggctgag gcctccgaag ctctggaagc gcaagccctg gcgcgggggg tggcagagct      960

gagtctggcc gactatgcct tcaccagcta ctccccttcc ctcctggcga tctgctgcct     1020

ggcgctggcg gaccgcatgc tgcgggtctc gcggcccgtg gacttgcgac tgggagacca     1080

cccggaggcg gcgctggagg actgtatggg caagttgcag ctgctggtgg ccataaacag     1140

tacttccttg actcacatgc tgcccgttca gatctgcgag aagtgcagcc tgcccccgag     1200

ctcgaaataa aacagatcct tcgtttcctt ttagtccctg gcccggctgc tggacctctc     1260

ccgtagcctc agaagagtgc agtactggtc cacagagaag gcttcaggac ctgcttggtc     1320

agctgcaggt tgtaaatagt gtacgatact agcatctggt attttattta ttttgcagcg     1380

agcacatgag gaagctgagt ctttcaccaa taaacagttg tggtttgtct aaaaaaaaaa     1440

aaaaaaaa                                                              1448


<210>  10
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Val Thr Pro Cys Pro Thr Ser Pro Ser Ser Pro Ala Ala Arg Ala 
1               5                   10                  15      


Gly Arg Arg Asp Asn Asp Gln Asn Leu Arg Ala Pro Val Lys Lys Ser 
            20                  25                  30          


Arg Arg Pro Arg Leu Arg Arg Lys Gln Pro Leu His Pro Leu Asn Pro 
        35                  40                  45              


Cys Pro Leu Pro Gly Asp Ser Gly Ile Cys Asp Leu Phe Glu Ser Pro 
    50                  55                  60                  


Ser Ser Gly Ser Asp Gly Ala Glu Ser Pro Ser Ala Ala Arg Gly Gly 
65                  70                  75                  80  


Ser Pro Leu Pro Gly Pro Ala Gln Pro Val Ala Gln Leu Asp Leu Gln 
                85                  90                  95      


Thr Phe Arg Asp Tyr Gly Gln Ser Cys Tyr Ala Phe Arg Lys Ala Gln 
            100                 105                 110         


Glu Ser His Phe His Pro Arg Glu Ala Leu Ala Arg Gln Pro Gln Val 
        115                 120                 125             


Thr Ala Glu Ser Arg Cys Lys Leu Leu Ser Trp Leu Ile Pro Val His 
    130                 135                 140                 


Arg Gln Phe Gly Leu Ser Phe Glu Ser Leu Cys Leu Thr Val Asn Thr 
145                 150                 155                 160 


Leu Asp Arg Phe Leu Thr Thr Thr Pro Val Ala Ala Asp Cys Phe Gln 
                165                 170                 175     


Leu Leu Gly Val Thr Ser Leu Leu Ile Ala Cys Lys Gln Val Glu Val 
            180                 185                 190         


His Pro Pro Arg Val Lys Gln Leu Leu Ala Leu Cys Cys Gly Ala Phe 
        195                 200                 205             


Ser Arg Gln Gln Leu Cys Asn Leu Glu Cys Ile Val Leu His Lys Leu 
    210                 215                 220                 


His Phe Thr Leu Gly Ala Pro Thr Ile Ser Phe Phe Leu Glu His Phe 
225                 230                 235                 240 


Thr His Ala Arg Val Glu Ala Gly Gln Ala Glu Ala Ser Glu Ala Leu 
                245                 250                 255     


Glu Ala Gln Ala Leu Ala Arg Gly Val Ala Glu Leu Ser Leu Ala Asp 
            260                 265                 270         


Tyr Ala Phe Thr Ser Tyr Ser Pro Ser Leu Leu Ala Ile Cys Cys Leu 
        275                 280                 285             


Ala Leu Ala Asp Arg Met Leu Arg Val Ser Arg Pro Val Asp Leu Arg 
    290                 295                 300                 


Leu Gly Asp His Pro Glu Ala Ala Leu Glu Asp Cys Met Gly Lys Leu 
305                 310                 315                 320 


Gln Leu Leu Val Ala Ile Asn Ser Thr Ser Leu Thr His Met Leu Pro 
                325                 330                 335     


Val Gln Ile Cys Glu Lys Cys Ser Leu Pro Pro Ser Ser Lys 
            340                 345                 350 


<210>  11
<211>  4134
<212>  DNA
<213>  Homo sapiens

<400>  11
aggcctccct cgccagcggg gtgtggctcc cctccaaaga cggtcggctg acaggctcca       60

cagagctcca ctcacgctca gccctggacg gacaggcagt ccaacggaac agaaacatcc      120

ctcagcccac aggcacgatc tgttcctcct gggaagatgc agaggctcat gatgctcctc      180

gccacatcgg gcgcctgcct gggcctgctg gcagtggcag cagtggcagc agcaggtgct      240

aaccctgccc aacgggacac ccacagcctg ctgcccaccc accggcgcca aaagagagat      300

tggatttgga accagatgca cattgatgaa gagaaaaaca cctcacttcc ccatcatgta      360

ggcaagatca agtcaagcgt gagtcgcaag aatgccaagt acctgctcaa aggagaatat      420

gtgggcaagg tcttccgggt cgatgcagag acaggagacg tgttcgccat tgagaggctg      480

gaccgggaga atatctcaga gtaccacctc actgctgtca ttgtggacaa ggacactggc      540

gaaaacctgg agactccttc cagcttcacc atcaaagttc atgacgtgaa cgacaactgg      600

cctgtgttca cgcatcggtt gttcaatgcg tccgtgcctg agtcgtcggc tgtggggacc      660

tcagtcatct ctgtgacagc agtggatgca gacgacccca ctgtgggaga ccacgcctct      720

gtcatgtacc aaatcctgaa ggggaaagag tattttgcca tcgataattc tggacgtatt      780

atcacaataa cgaaaagctt ggaccgagag aagcaggcca ggtatgagat cgtggtggaa      840

gcgcgagatg cccagggcct ccggggggac tcgggcacgg ccaccgtgct ggtcactctg      900

caagacatca atgacaactt ccccttcttc acccagacca agtacacatt tgtcgtgcct      960

gaagacaccc gtgtgggcac ctctgtgggc tctctgtttg ttgaggaccc agatgagccc     1020

cagaaccgga tgaccaagta cagcatcttg cggggcgact accaggacgc tttcaccatt     1080

gagacaaacc ccgcccacaa cgagggcatc atcaagccca tgaagcctct ggattatgaa     1140

tacatccagc aatacagctt catcgtcgag gccacagacc ccaccatcga cctccgatac     1200

atgagccctc ccgcgggaaa cagagcccag gtcattatca acatcacaga tgtggacgag     1260

ccccccattt tccagcagcc tttctaccac ttccagctga aggaaaacca gaagaagcct     1320

ctgattggca cagtgctggc catggaccct gatgcggcta ggcatagcat tggatactcc     1380

atccgcagga ccagtgacaa gggccagttc ttccgagtca caaaaaaggg ggacatttac     1440

aatgagaaag aactggacag agaagtctac ccctggtata acctgactgt ggaggccaaa     1500

gaactggatt ccactggaac ccccacagga aaagaatcca ttgtgcaagt ccacattgaa     1560

gttttggatg agaatgacaa tgccccggag tttgccaagc cctaccagcc caaagtgtgt     1620

gagaacgctg tccatggcca gctggtcctg cagatctccg caatagacaa ggacataaca     1680

ccacgaaacg tgaagttcaa attcatcttg aatactgaga acaactttac cctcacggat     1740

aatcacgata acacggccaa catcacagtc aagtatgggc agtttgaccg ggagcatacc     1800

aaggtccact tcctacccgt ggtcatctca gacaatggga tgccaagtcg cacgggcacc     1860

agcacgctga ccgtggccgt gtgcaagtgc aacgagcagg gcgagttcac cttctgcgag     1920

gatatggccg cccaggtggg cgtgagcatc caggcagtgg tagccatctt actctgcatc     1980

ctcaccatca cagtgatcac cctgctcatc ttcctgcggc ggcggctccg gaagcaggcc     2040

cgcgcgcacg gcaagagcgt gccggagatc cacgagcagc tggtcaccta cgacgaggag     2100

ggcggcggcg agatggacac caccagctac gatgtgtcgg tgctcaactc ggtgcgccgc     2160

ggcggggcca agcccccgcg gcccgcgctg gacgcccggc cttccctcta tgcgcaggtg     2220

cagaagccac cgaggcacgc gcctggggca cacggagggc ccggggagat ggcagccatg     2280

atcgaggtga agaaggacga ggcggaccac gacggcgacg gcccccccta cgacacgctg     2340

cacatctacg gctacgaggg ctccgagtcc atagccgagt ccctcagctc cctgggcacc     2400

gactcatccg actctgacgt ggattacgac ttccttaacg actggggacc caggtttaag     2460

atgctggctg agctgtacgg ctcggacccc cgggaggagc tgctgtatta ggcggccgag     2520

gtcactctgg gcctggggac ccaaaccccc tgcagcccag gccagtcaga cgccaggcac     2580

cacagcctcc aaaaatggca gtgactcccc agcccagcac cccttcctcg tgggtcccag     2640

agacctcatc agccttggga tagcaaactc caggttcctg aaatatccag gaatatatgt     2700

cagtgatgac tattctcaaa tgctggcaaa tccaggctgg tgttctgtct gggctcagac     2760

atccacataa ccctgtcacc cacagaccgc cgtctaactc aaagacttcc tctggctccc     2820

caaggctgca aagcaaaaca gactgtgttt aactgctgca gggtcttttt ctagggtccc     2880

tgaacgccct ggtaaggctg gtgaggtcct ggtgcctatc tgcctggagg caaaggcctg     2940

gacagcttga cttgtggggc aggattctct gcagcccatt cccaagggag actgaccatc     3000

atgccctctc tcgggagccc tagccctgct ccaactccat actccactcc aagtgcccca     3060

ccactcccca acccctctcc aggcctgtca agagggagga aggggcccca tggcagctcc     3120

tgaccttggg tcctgaagtg acctcactgg cctgccatgc cagtaactgt gctgtactga     3180

gcactgaacc acattcaggg aaatggctta ttaaactttg aagcaactgt gaattcattc     3240

tggaggggca gtggagatca ggagtgacag atcacagggt gagggccacc tccacaccca     3300

ccccctctgg agaaggcctg gaagagctga gaccttgctt tgagactcct cagcacccct     3360

ccagttttgc ctgagaaggg gcagatgttc ccggagcaga agacgtctcc ccttctctgc     3420

ctcacctggt cgccaatcca tgctctcttt cttttctctg tctactcctt atcccttggt     3480

ttagaggaac ccaagatgtg gcctttagca aaactggaca atgtccaaac ccactcatga     3540

ctgcatgacg gagccgagcc atgtgtcttt acacctcgct gttgtcacat ctcagggaac     3600

tgaccctcag gcacaccttg cagaaggcaa ggccctgccc tgcccaacct ctgtggtcac     3660

ccatgcatct tccactggaa cgtttcactg caaacacacc ttggagaagt ggcatcagtc     3720

aacagagagg ggcagggaag gagacaccaa gctcaccctt cgtcatggac cgaggttccc     3780

actctgggca aagcccctca cactgcaagg gattgtagat aacactgact tgtttgtttt     3840

aaccaataac tagcttctta taatgatttt tttactaatg atacttacaa gtttctagct     3900

ctcacagaca tatagaataa gggtttttgc ataataagca ggttgttatt taggttaaca     3960

atattaattc aggtttttta gttggaaaaa caattcctgt aaccttctat tttctataat     4020

tgtagtaatt gctctacaga taatgtctat atattggcca aactggtgca tgacaagtac     4080

tgtatttttt tatacctaaa taaagaaaaa tctttagcct gggcaacaaa aaaa           4134


<210>  12
<211>  784
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Gln Arg Leu Met Met Leu Leu Ala Thr Ser Gly Ala Cys Leu Gly 
1               5                   10                  15      


Leu Leu Ala Val Ala Ala Val Ala Ala Ala Gly Ala Asn Pro Ala Gln 
            20                  25                  30          


Arg Asp Thr His Ser Leu Leu Pro Thr His Arg Arg Gln Lys Arg Asp 
        35                  40                  45              


Trp Ile Trp Asn Gln Met His Ile Asp Glu Glu Lys Asn Thr Ser Leu 
    50                  55                  60                  


Pro His His Val Gly Lys Ile Lys Ser Ser Val Ser Arg Lys Asn Ala 
65                  70                  75                  80  


Lys Tyr Leu Leu Lys Gly Glu Tyr Val Gly Lys Val Phe Arg Val Asp 
                85                  90                  95      


Ala Glu Thr Gly Asp Val Phe Ala Ile Glu Arg Leu Asp Arg Glu Asn 
            100                 105                 110         


Ile Ser Glu Tyr His Leu Thr Ala Val Ile Val Asp Lys Asp Thr Gly 
        115                 120                 125             


Glu Asn Leu Glu Thr Pro Ser Ser Phe Thr Ile Lys Val His Asp Val 
    130                 135                 140                 


Asn Asp Asn Trp Pro Val Phe Thr His Arg Leu Phe Asn Ala Ser Val 
145                 150                 155                 160 


Pro Glu Ser Ser Ala Val Gly Thr Ser Val Ile Ser Val Thr Ala Val 
                165                 170                 175     


Asp Ala Asp Asp Pro Thr Val Gly Asp His Ala Ser Val Met Tyr Gln 
            180                 185                 190         


Ile Leu Lys Gly Lys Glu Tyr Phe Ala Ile Asp Asn Ser Gly Arg Ile 
        195                 200                 205             


Ile Thr Ile Thr Lys Ser Leu Asp Arg Glu Lys Gln Ala Arg Tyr Glu 
    210                 215                 220                 


Ile Val Val Glu Ala Arg Asp Ala Gln Gly Leu Arg Gly Asp Ser Gly 
225                 230                 235                 240 


Thr Ala Thr Val Leu Val Thr Leu Gln Asp Ile Asn Asp Asn Phe Pro 
                245                 250                 255     


Phe Phe Thr Gln Thr Lys Tyr Thr Phe Val Val Pro Glu Asp Thr Arg 
            260                 265                 270         


Val Gly Thr Ser Val Gly Ser Leu Phe Val Glu Asp Pro Asp Glu Pro 
        275                 280                 285             


Gln Asn Arg Met Thr Lys Tyr Ser Ile Leu Arg Gly Asp Tyr Gln Asp 
    290                 295                 300                 


Ala Phe Thr Ile Glu Thr Asn Pro Ala His Asn Glu Gly Ile Ile Lys 
305                 310                 315                 320 


Pro Met Lys Pro Leu Asp Tyr Glu Tyr Ile Gln Gln Tyr Ser Phe Ile 
                325                 330                 335     


Val Glu Ala Thr Asp Pro Thr Ile Asp Leu Arg Tyr Met Ser Pro Pro 
            340                 345                 350         


Ala Gly Asn Arg Ala Gln Val Ile Ile Asn Ile Thr Asp Val Asp Glu 
        355                 360                 365             


Pro Pro Ile Phe Gln Gln Pro Phe Tyr His Phe Gln Leu Lys Glu Asn 
    370                 375                 380                 


Gln Lys Lys Pro Leu Ile Gly Thr Val Leu Ala Met Asp Pro Asp Ala 
385                 390                 395                 400 


Ala Arg His Ser Ile Gly Tyr Ser Ile Arg Arg Thr Ser Asp Lys Gly 
                405                 410                 415     


Gln Phe Phe Arg Val Thr Lys Lys Gly Asp Ile Tyr Asn Glu Lys Glu 
            420                 425                 430         


Leu Asp Arg Glu Val Tyr Pro Trp Tyr Asn Leu Thr Val Glu Ala Lys 
        435                 440                 445             


Glu Leu Asp Ser Thr Gly Thr Pro Thr Gly Lys Glu Ser Ile Val Gln 
    450                 455                 460                 


Val His Ile Glu Val Leu Asp Glu Asn Asp Asn Ala Pro Glu Phe Ala 
465                 470                 475                 480 


Lys Pro Tyr Gln Pro Lys Val Cys Glu Asn Ala Val His Gly Gln Leu 
                485                 490                 495     


Val Leu Gln Ile Ser Ala Ile Asp Lys Asp Ile Thr Pro Arg Asn Val 
            500                 505                 510         


Lys Phe Lys Phe Ile Leu Asn Thr Glu Asn Asn Phe Thr Leu Thr Asp 
        515                 520                 525             


Asn His Asp Asn Thr Ala Asn Ile Thr Val Lys Tyr Gly Gln Phe Asp 
    530                 535                 540                 


Arg Glu His Thr Lys Val His Phe Leu Pro Val Val Ile Ser Asp Asn 
545                 550                 555                 560 


Gly Met Pro Ser Arg Thr Gly Thr Ser Thr Leu Thr Val Ala Val Cys 
                565                 570                 575     


Lys Cys Asn Glu Gln Gly Glu Phe Thr Phe Cys Glu Asp Met Ala Ala 
            580                 585                 590         


Gln Val Gly Val Ser Ile Gln Ala Val Val Ala Ile Leu Leu Cys Ile 
        595                 600                 605             


Leu Thr Ile Thr Val Ile Thr Leu Leu Ile Phe Leu Arg Arg Arg Leu 
    610                 615                 620                 


Arg Lys Gln Ala Arg Ala His Gly Lys Ser Val Pro Glu Ile His Glu 
625                 630                 635                 640 


Gln Leu Val Thr Tyr Asp Glu Glu Gly Gly Gly Glu Met Asp Thr Thr 
                645                 650                 655     


Ser Tyr Asp Val Ser Val Leu Asn Ser Val Arg Arg Gly Gly Ala Lys 
            660                 665                 670         


Pro Pro Arg Pro Ala Leu Asp Ala Arg Pro Ser Leu Tyr Ala Gln Val 
        675                 680                 685             


Gln Lys Pro Pro Arg His Ala Pro Gly Ala His Gly Gly Pro Gly Glu 
    690                 695                 700                 


Met Ala Ala Met Ile Glu Val Lys Lys Asp Glu Ala Asp His Asp Gly 
705                 710                 715                 720 


Asp Gly Pro Pro Tyr Asp Thr Leu His Ile Tyr Gly Tyr Glu Gly Ser 
                725                 730                 735     


Glu Ser Ile Ala Glu Ser Leu Ser Ser Leu Gly Thr Asp Ser Ser Asp 
            740                 745                 750         


Ser Asp Val Asp Tyr Asp Phe Leu Asn Asp Trp Gly Pro Arg Phe Lys 
        755                 760                 765             


Met Leu Ala Glu Leu Tyr Gly Ser Asp Pro Arg Glu Glu Leu Leu Tyr 
    770                 775                 780                 


<210>  13
<211>  5177
<212>  DNA
<213>  Homo sapiens

<400>  13
gggcgccgtc cgcctgaggg gctgcagatc ccggctaccg cgagcgccgt ggctggcttg       60

gctgttccat gtggctccgg cggggatgga ggactcggtg gcggcggcgg ctgctgctgc      120

ggcggcgacg gaggagcggc tatgagaagg gaacggggcc agactcagcc cgacagcggg      180

attagagccc tccagaatac ccatcatata gcccctgagg tggcatggtg atgtctccat      240

gagggaaccc cttcccactc atcctgtcac gtatatcata gtgttcttga ctgggccatt      300

catctaagat gggatttacc ctgtgaaaca gggagaagac ttatggaccc caagcatcat      360

ttcgagttgt agttgagttt ttaaaagaca tacatgcaaa gttcctttgc tttggaccct      420

ctgcattatt aaagctgctg tattgctaac ccagaactgc tccagtgtct tgactgatca      480

tcatggcttc agtttggaag agactgcagc gtgtgggaaa acatgcatcc aagttccagt      540

ttgtggcctc ctaccaggag ctcatggttg agtgtacgaa gaaatggcaa ccagataaac      600

tggtggtagt ttggaccaga agaagccgaa ggaagtcttc taaggcacat agctggcaac      660

ctggaataaa aaatccctat cgtggtgttg ttgtgtggcc tgttcctgaa aacattgaaa      720

tcactgtaac actttttaag gatcctcatg cggaagaatt tgaagacaaa gagtggacat      780

ttgtcataga aaatgaatcc ccttctggtc gaaggaaagc tcttgctact agcagcatca      840

atatgaaaca gtatgcaagc cctatgccaa ctcagactga tgtcaagtta aaattcaagc      900

cattatctaa aaaagttgta tctgccgctc ttcagttttc attatcttgc atttttctga      960

gggaaggaaa agccacagat gaagacatgc aaagtttggc tagtttgatg agtatgaagc     1020

aggctgacat tggcaattta gatgacttcg aagaagataa tgaagatgat gatgagaaca     1080

gagtgaacca agaagaaaag gcagctaaaa ttacagaaat tgtaaaccag ttgaatgctc     1140

tgagcagctt agatgaagat caagatgact gcataaagca agcaaatatg cgttcagcta     1200

aatcagccag ttcctctgaa gagcttatca acaaacttaa ctttttggat gaagcagaaa     1260

aggacttggc caccgtgaat tcaaatccat ttgatgatcc tgatgctgca gaattaaatc     1320

catttggaga tcctgactca gaagaaccta tcactgaaac agcttcacct agaaaaacag     1380

aagactcttt ttataataac agctataatc cctttaaaga ggtgcagact ccacagtatt     1440

tgaacccatt cgatgagcca gaagcatttg tgaccataaa ggattctcct ccccagtcta     1500

caaaaagaaa aaatataaga cctgtggata tgagcaagta cctctatgct gatagttcta     1560

aaactgaaga agaagaattg gatgaatcaa atccttttta tgaacctaaa tcaactcctc     1620

ctccaaataa tttggtaaat cctgttcaag aactagaaac tgaaaggcga gtgaaaagaa     1680

aggccccggc tccaccagtc ctctcaccaa aaacaggagt attaaatgaa aacacagttt     1740

ctgcaggaaa agatctctct acttctccta agccaagccc tataccaagt cctgttttgg     1800

ggcgaaagcc aaatgctagt cagtctttgc ttgtatggtg taaagaagtt acaaagaact     1860

accgaggagt aaaaatcacc aattttacta catcgtggag aaatggttta tctttttgtg     1920

caatattaca ccactttaga ccagatttaa ttgactacaa gtctctgaat cctcaagata     1980

ttaaagagaa caacaaaaag gcatacgatg gatttgccag cataggaatt tcccgattat     2040

tggaaccttc tgatatggta ttattagcaa ttcctgataa actgactgtt atgacttatc     2100

tctatcaaat aagggcacat ttcagtggcc aagaactaaa tgtcgttcag atagaggaaa     2160

acagcagtaa aagcacatat aaagttggaa actatgaaac agatacaaac agttctgttg     2220

atcaagaaaa attctatgca gagcttagtg atctgaagcg ggagcctgaa ctacaacagc     2280

ctatcagcgg agcagtagac ttcttatcac aggatgactc tgtatttgta aatgatagcg     2340

gggttggaga gtcagaaagt gagcatcaaa ctcctgatga tcaccttagt ccaagcacag     2400

cctcccctta ctgtcgcagg actaaaagtg acacagaacc ccagaagtct cagcagagct     2460

ctggaaggac ttcaggatct gatgaccctg gaatatgttc caatacagat tcaacccaag     2520

cacaggtttt gttaggcaaa aagagactat tgaaagctga gactttagaa ttgagtgact     2580

tatatgttag tgataagaag aaggatatgt ctccaccctt tatttgtgag gagacagatg     2640

aacaaaagct tcaaactcta gacatcggta gtaacttgga gaaagaaaaa ttagagaatt     2700

ccagatcctt agaatgcaga tcagatccag aatctcctat caaaaaaaca agtttatctc     2760

ctacttctaa acttggatac tcatatagta gagatctaga ccttgctaag aaaaaacatg     2820

cttccctgag gcagacggag tctgatccag atgctgatag aaccacttta aatcatgcag     2880

atcattcatc aaaaatagtc cagcatcgat tgttatctag acaagaagaa cttaaggaaa     2940

gagcaagagt tctgcttgag caagcaagaa gagatgcagc cttaaaggcg gggaataagc     3000

acaataccaa cacagccacc ccattctgca acaggcagct aagtgatcag caagatgaag     3060

agcgacgtcg gcagctgaga gagagagctc gtcagctaat agcagaagct cgatctggag     3120

tgaagatgtc agaacttccc agctatggtg aaatggctgc agaaaagttg aaagaaaggt     3180

caaaggcatc tggagatgaa aatgataata ttgagataga tactaacgag gagatccctg     3240

aaggctttgt tgtaggaggt ggagatgaac ttactaactt agaaaatgac cttgatactc     3300

ccgaacaaaa cagtaagttg gtggacttga agctgaagaa gctcctagaa gttcagccac     3360

aggtggcaaa ttcaccctcc agtgctgccc agaaagctgt aactgagagc tcagagcagg     3420

acatgaaaag tggcacagaa gatctccgga ctgaacgatt acaaaaaaca acagaacgtt     3480

ttagaaatcc tgttgtgttc agcaaagatt ctacagtcag aaaaactcaa cttcagtctt     3540

tcagccaata tattgagaat agaccagaga tgaaaaggca gagatcaata caggaagata     3600

caaagaaagg aaatgaggag aaggcagcga taactgaaac tcagaggaag ccatcagaag     3660

atgaagtgct taataaaggg ttcaaagaca ccagtcagta tgtagtagga gaattggcag     3720

cactagagaa tgagcaaaag caaattgaca cccgtgccgc gctggtggag aagcgccttc     3780

gctatctcat ggacacagga aggaacacag aagaagaaga agctatgatg caggaatggt     3840

ttatgttagt taataagaaa aatgccttaa taaggagaat gaatcagctc tctcttctgg     3900

aaaaagaaca tgatttagaa cgacggtatg agctgctgaa ccgggaattg agggcaatgc     3960

tagccattga agactggcag aagaccgagg cccagaagcg acgcgaacag cttctgctag     4020

atgagctggt ggccctggtg aacaagcgcg atgcgctcgt cagggacctg gacgcgcagg     4080

agaagcaggc cgaagaagaa gatgagcatt tggagcgaac tctggagcaa aacaaaggca     4140

agatggccaa gaaagaggag aaatgtgttc ttcagtagcc atcagatcag aaagaatctc     4200

tcccaacatt ttagagtctt gcttcccaaa ccagaaaaag tcagactcat tgttgattta     4260

aaacttttaa cattttgttt ggctggattg tactacttta cctctacttt accaccacca     4320

cccttttcct ccctcctttc caaataatat acagaactcc aaaatagctt catttaagga     4380

tttttttgtg agttaacaat ttccttgaaa tcctgtgaaa tagatttgca cagacacctt     4440

gtgagtgatt ggtattggag gtgttcaaga aactgttcga aaaagaacaa aaacacttcc     4500

ctcgttattt tctctcattt tttgatgaga ggaaaatttg aaacattatt cttgttgttg     4560

ttggtaatag cataatgaca gtgggagggg tacaagggga taagaaaaat gtcatgattt     4620

ttttccggtc ctgccacatg taacacttac tctgttacct aaattttata gttagatcat     4680

atccaatcta cttattaaac tgtgttctat ttaccagtgg agtttttctg cagtggttgc     4740

gtttcactgt aaggataatg gagttcctct cctctgcttt cctcagagga tggtccttta     4800

acatagccag aaacaagccc tgtggtttga aggtgagctg tgaggatggg actaattgat     4860

atgcaccagt ttacaaagac agtcttatca tccgagaata caccatcttt ttctctggat     4920

aattatttct tacatcatgc ttgattccta cattttgttg ggtctcaaca ttggctcacg     4980

aatgctgtta atatttattc tgtattgata aaaagtctgt cttgccacta caagtaaatc     5040

ccccatttaa tattttcttc tttagcatag cactgtcatt ttttgtgaaa atggttatgt     5100

ttatttatta caatactgag tcatatataa attttcaata aaagcagaaa ctttcttacc     5160

ttaaaaaaaa aaaaaaa                                                    5177


<210>  14
<211>  1231
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Ser Val Trp Lys Arg Leu Gln Arg Val Gly Lys His Ala Ser 
1               5                   10                  15      


Lys Phe Gln Phe Val Ala Ser Tyr Gln Glu Leu Met Val Glu Cys Thr 
            20                  25                  30          


Lys Lys Trp Gln Pro Asp Lys Leu Val Val Val Trp Thr Arg Arg Ser 
        35                  40                  45              


Arg Arg Lys Ser Ser Lys Ala His Ser Trp Gln Pro Gly Ile Lys Asn 
    50                  55                  60                  


Pro Tyr Arg Gly Val Val Val Trp Pro Val Pro Glu Asn Ile Glu Ile 
65                  70                  75                  80  


Thr Val Thr Leu Phe Lys Asp Pro His Ala Glu Glu Phe Glu Asp Lys 
                85                  90                  95      


Glu Trp Thr Phe Val Ile Glu Asn Glu Ser Pro Ser Gly Arg Arg Lys 
            100                 105                 110         


Ala Leu Ala Thr Ser Ser Ile Asn Met Lys Gln Tyr Ala Ser Pro Met 
        115                 120                 125             


Pro Thr Gln Thr Asp Val Lys Leu Lys Phe Lys Pro Leu Ser Lys Lys 
    130                 135                 140                 


Val Val Ser Ala Ala Leu Gln Phe Ser Leu Ser Cys Ile Phe Leu Arg 
145                 150                 155                 160 


Glu Gly Lys Ala Thr Asp Glu Asp Met Gln Ser Leu Ala Ser Leu Met 
                165                 170                 175     


Ser Met Lys Gln Ala Asp Ile Gly Asn Leu Asp Asp Phe Glu Glu Asp 
            180                 185                 190         


Asn Glu Asp Asp Asp Glu Asn Arg Val Asn Gln Glu Glu Lys Ala Ala 
        195                 200                 205             


Lys Ile Thr Glu Ile Val Asn Gln Leu Asn Ala Leu Ser Ser Leu Asp 
    210                 215                 220                 


Glu Asp Gln Asp Asp Cys Ile Lys Gln Ala Asn Met Arg Ser Ala Lys 
225                 230                 235                 240 


Ser Ala Ser Ser Ser Glu Glu Leu Ile Asn Lys Leu Asn Phe Leu Asp 
                245                 250                 255     


Glu Ala Glu Lys Asp Leu Ala Thr Val Asn Ser Asn Pro Phe Asp Asp 
            260                 265                 270         


Pro Asp Ala Ala Glu Leu Asn Pro Phe Gly Asp Pro Asp Ser Glu Glu 
        275                 280                 285             


Pro Ile Thr Glu Thr Ala Ser Pro Arg Lys Thr Glu Asp Ser Phe Tyr 
    290                 295                 300                 


Asn Asn Ser Tyr Asn Pro Phe Lys Glu Val Gln Thr Pro Gln Tyr Leu 
305                 310                 315                 320 


Asn Pro Phe Asp Glu Pro Glu Ala Phe Val Thr Ile Lys Asp Ser Pro 
                325                 330                 335     


Pro Gln Ser Thr Lys Arg Lys Asn Ile Arg Pro Val Asp Met Ser Lys 
            340                 345                 350         


Tyr Leu Tyr Ala Asp Ser Ser Lys Thr Glu Glu Glu Glu Leu Asp Glu 
        355                 360                 365             


Ser Asn Pro Phe Tyr Glu Pro Lys Ser Thr Pro Pro Pro Asn Asn Leu 
    370                 375                 380                 


Val Asn Pro Val Gln Glu Leu Glu Thr Glu Arg Arg Val Lys Arg Lys 
385                 390                 395                 400 


Ala Pro Ala Pro Pro Val Leu Ser Pro Lys Thr Gly Val Leu Asn Glu 
                405                 410                 415     


Asn Thr Val Ser Ala Gly Lys Asp Leu Ser Thr Ser Pro Lys Pro Ser 
            420                 425                 430         


Pro Ile Pro Ser Pro Val Leu Gly Arg Lys Pro Asn Ala Ser Gln Ser 
        435                 440                 445             


Leu Leu Val Trp Cys Lys Glu Val Thr Lys Asn Tyr Arg Gly Val Lys 
    450                 455                 460                 


Ile Thr Asn Phe Thr Thr Ser Trp Arg Asn Gly Leu Ser Phe Cys Ala 
465                 470                 475                 480 


Ile Leu His His Phe Arg Pro Asp Leu Ile Asp Tyr Lys Ser Leu Asn 
                485                 490                 495     


Pro Gln Asp Ile Lys Glu Asn Asn Lys Lys Ala Tyr Asp Gly Phe Ala 
            500                 505                 510         


Ser Ile Gly Ile Ser Arg Leu Leu Glu Pro Ser Asp Met Val Leu Leu 
        515                 520                 525             


Ala Ile Pro Asp Lys Leu Thr Val Met Thr Tyr Leu Tyr Gln Ile Arg 
    530                 535                 540                 


Ala His Phe Ser Gly Gln Glu Leu Asn Val Val Gln Ile Glu Glu Asn 
545                 550                 555                 560 


Ser Ser Lys Ser Thr Tyr Lys Val Gly Asn Tyr Glu Thr Asp Thr Asn 
                565                 570                 575     


Ser Ser Val Asp Gln Glu Lys Phe Tyr Ala Glu Leu Ser Asp Leu Lys 
            580                 585                 590         


Arg Glu Pro Glu Leu Gln Gln Pro Ile Ser Gly Ala Val Asp Phe Leu 
        595                 600                 605             


Ser Gln Asp Asp Ser Val Phe Val Asn Asp Ser Gly Val Gly Glu Ser 
    610                 615                 620                 


Glu Ser Glu His Gln Thr Pro Asp Asp His Leu Ser Pro Ser Thr Ala 
625                 630                 635                 640 


Ser Pro Tyr Cys Arg Arg Thr Lys Ser Asp Thr Glu Pro Gln Lys Ser 
                645                 650                 655     


Gln Gln Ser Ser Gly Arg Thr Ser Gly Ser Asp Asp Pro Gly Ile Cys 
            660                 665                 670         


Ser Asn Thr Asp Ser Thr Gln Ala Gln Val Leu Leu Gly Lys Lys Arg 
        675                 680                 685             


Leu Leu Lys Ala Glu Thr Leu Glu Leu Ser Asp Leu Tyr Val Ser Asp 
    690                 695                 700                 


Lys Lys Lys Asp Met Ser Pro Pro Phe Ile Cys Glu Glu Thr Asp Glu 
705                 710                 715                 720 


Gln Lys Leu Gln Thr Leu Asp Ile Gly Ser Asn Leu Glu Lys Glu Lys 
                725                 730                 735     


Leu Glu Asn Ser Arg Ser Leu Glu Cys Arg Ser Asp Pro Glu Ser Pro 
            740                 745                 750         


Ile Lys Lys Thr Ser Leu Ser Pro Thr Ser Lys Leu Gly Tyr Ser Tyr 
        755                 760                 765             


Ser Arg Asp Leu Asp Leu Ala Lys Lys Lys His Ala Ser Leu Arg Gln 
    770                 775                 780                 


Thr Glu Ser Asp Pro Asp Ala Asp Arg Thr Thr Leu Asn His Ala Asp 
785                 790                 795                 800 


His Ser Ser Lys Ile Val Gln His Arg Leu Leu Ser Arg Gln Glu Glu 
                805                 810                 815     


Leu Lys Glu Arg Ala Arg Val Leu Leu Glu Gln Ala Arg Arg Asp Ala 
            820                 825                 830         


Ala Leu Lys Ala Gly Asn Lys His Asn Thr Asn Thr Ala Thr Pro Phe 
        835                 840                 845             


Cys Asn Arg Gln Leu Ser Asp Gln Gln Asp Glu Glu Arg Arg Arg Gln 
    850                 855                 860                 


Leu Arg Glu Arg Ala Arg Gln Leu Ile Ala Glu Ala Arg Ser Gly Val 
865                 870                 875                 880 


Lys Met Ser Glu Leu Pro Ser Tyr Gly Glu Met Ala Ala Glu Lys Leu 
                885                 890                 895     


Lys Glu Arg Ser Lys Ala Ser Gly Asp Glu Asn Asp Asn Ile Glu Ile 
            900                 905                 910         


Asp Thr Asn Glu Glu Ile Pro Glu Gly Phe Val Val Gly Gly Gly Asp 
        915                 920                 925             


Glu Leu Thr Asn Leu Glu Asn Asp Leu Asp Thr Pro Glu Gln Asn Ser 
    930                 935                 940                 


Lys Leu Val Asp Leu Lys Leu Lys Lys Leu Leu Glu Val Gln Pro Gln 
945                 950                 955                 960 


Val Ala Asn Ser Pro Ser Ser Ala Ala Gln Lys Ala Val Thr Glu Ser 
                965                 970                 975     


Ser Glu Gln Asp Met Lys Ser Gly Thr Glu Asp Leu Arg Thr Glu Arg 
            980                 985                 990         


Leu Gln Lys Thr Thr Glu Arg Phe  Arg Asn Pro Val Val  Phe Ser Lys 
        995                 1000                 1005             


Asp Ser  Thr Val Arg Lys Thr  Gln Leu Gln Ser Phe  Ser Gln Tyr 
    1010                 1015                 1020             


Ile Glu  Asn Arg Pro Glu Met  Lys Arg Gln Arg Ser  Ile Gln Glu 
    1025                 1030                 1035             


Asp Thr  Lys Lys Gly Asn Glu  Glu Lys Ala Ala Ile  Thr Glu Thr 
    1040                 1045                 1050             


Gln Arg  Lys Pro Ser Glu Asp  Glu Val Leu Asn Lys  Gly Phe Lys 
    1055                 1060                 1065             


Asp Thr  Ser Gln Tyr Val Val  Gly Glu Leu Ala Ala  Leu Glu Asn 
    1070                 1075                 1080             


Glu Gln  Lys Gln Ile Asp Thr  Arg Ala Ala Leu Val  Glu Lys Arg 
    1085                 1090                 1095             


Leu Arg  Tyr Leu Met Asp Thr  Gly Arg Asn Thr Glu  Glu Glu Glu 
    1100                 1105                 1110             


Ala Met  Met Gln Glu Trp Phe  Met Leu Val Asn Lys  Lys Asn Ala 
    1115                 1120                 1125             


Leu Ile  Arg Arg Met Asn Gln  Leu Ser Leu Leu Glu  Lys Glu His 
    1130                 1135                 1140             


Asp Leu  Glu Arg Arg Tyr Glu  Leu Leu Asn Arg Glu  Leu Arg Ala 
    1145                 1150                 1155             


Met Leu  Ala Ile Glu Asp Trp  Gln Lys Thr Glu Ala  Gln Lys Arg 
    1160                 1165                 1170             


Arg Glu  Gln Leu Leu Leu Asp  Glu Leu Val Ala Leu  Val Asn Lys 
    1175                 1180                 1185             


Arg Asp  Ala Leu Val Arg Asp  Leu Asp Ala Gln Glu  Lys Gln Ala 
    1190                 1195                 1200             


Glu Glu  Glu Asp Glu His Leu  Glu Arg Thr Leu Glu  Gln Asn Lys 
    1205                 1210                 1215             


Gly Lys  Met Ala Lys Lys Glu  Glu Lys Cys Val Leu  Gln 
    1220                 1225                 1230     


<210>  15
<211>  5184
<212>  DNA
<213>  Homo sapiens

<400>  15
gctttacact cgcgagcgga ccgccacacg ggtccggtgc ccgctgcgct tccgccccag       60

cgctcctgag gcggccgtac aatcctcggc agtgtcctga gactgtatgg tcagctcagc      120

ccggcctccg actccttccg actcccagca ttcgagccac tttttttttt ctttgaaaac      180

tcagaaaagt gactcctttt ccagggaaaa aggaacttgg gttcccttct ctccgtcctc      240

ttttcgggtc tgacagcctc cacccactcc ttccccggac cccgcctccg cgcgcaggtt      300

cctcccagtc acctttctcc acccccgccc ccgcacctag cccgccgcgc gccaccttcc      360

acctgactgc gcggggcgct cgggacctgc gcgcacctcg gaccttcacc acccgcccgg      420

gccgcgggga gcggacgagg gccacagccc cccacccgcc agggagccca ggtgctcggc      480

gtctgaacgt ctcaaagggc cacagcgaca atgacagctg acaaggagaa gaaaaggagt      540

agctcggaga ggaggaagga gaagtcccgg gatgctgcgc ggtgccggcg gagcaaggag      600

acggaggtgt tctatgagct ggcccatgag ctgcctctgc cccacagtgt gagctcccat      660

ctggacaagg cctccatcat gcgactggca atcagcttcc tgcgaacaca caagctcctc      720

tcctcagttt gctctgaaaa cgagtccgaa gccgaagctg accagcagat ggacaacttg      780

tacctgaaag ccttggaggg tttcattgcc gtggtgaccc aagatggcga catgatcttt      840

ctgtcagaaa acatcagcaa gttcatggga cttacacagg tggagctaac aggacatagt      900

atctttgact tcactcatcc ctgcgaccat gaggagattc gtgagaacct gagtctcaaa      960

aatggctctg gttttgggaa aaaaagcaaa gacatgtcca cagagcggga cttcttcatg     1020

aggatgaagt gcacggtcac caacagaggc cgtactgtca acctcaagtc agccacctgg     1080

aaggtcttgc actgcacggg ccaggtgaaa gtctacaaca actgccctcc tcacaatagt     1140

ctgtgtggct acaaggagcc cctgctgtcc tgcctcatca tcatgtgtga accaatccag     1200

cacccatccc acatggacat ccccctggat agcaagacct tcctgagccg ccacagcatg     1260

gacatgaagt tcacctactg tgatgacaga atcacagaac tgattggtta ccaccctgag     1320

gagctgcttg gccgctcagc ctatgaattc taccatgcgc tagactccga gaacatgacc     1380

aagagtcacc agaacttgtg caccaagggt caggtagtaa gtggccagta ccggatgctc     1440

gcaaagcatg ggggctacgt gtggctggag acccagggga cggtcatcta caaccctcgc     1500

aacctgcagc cccagtgcat catgtgtgtc aactacgtcc tgagtgagat tgagaagaat     1560

gacgtggtgt tctccatgga ccagactgaa tccctgttca agccccacct gatggccatg     1620

aacagcatct ttgatagcag tggcaagggg gctgtgtctg agaagagtaa cttcctattc     1680

accaagctaa aggaggagcc cgaggagctg gcccagctgg ctcccacccc aggagacgcc     1740

atcatctctc tggatttcgg gaatcagaac ttcgaggagt cctcagccta tggcaaggcc     1800

atcctgcccc cgagccagcc atgggccacg gagttgagga gccacagcac ccagagcgag     1860

gctgggagcc tgcctgcctt caccgtgccc caggcagctg ccccgggcag caccaccccc     1920

agtgccacca gcagcagcag cagctgctcc acgcccaata gccctgaaga ctattacaca     1980

tctttggata acgacctgaa gattgaagtg attgagaagc tcttcgccat ggacacagag     2040

gccaaggacc aatgcagtac ccagacggat ttcaatgagc tggacttgga gacactggca     2100

ccctatatcc ccatggacgg ggaagacttc cagctaagcc ccatctgccc cgaggagcgg     2160

ctcttggcgg agaacccaca gtccaccccc cagcactgct tcagtgccat gacaaacatc     2220

ttccagccac tggcccctgt agccccgcac agtcccttcc tcctggacaa gtttcagcag     2280

cagctggaga gcaagaagac agagcccgag caccggccca tgtcctccat cttctttgat     2340

gccggaagca aagcatccct gccaccgtgc tgtggccagg ccagcacccc tctctcttcc     2400

atggggggca gatccaatac ccagtggccc ccagatccac cattacattt tgggcccaca     2460

aagtgggccg tcggggatca gcgcacagag ttcttgggag cagcgccgtt ggggccccct     2520

gtctctccac cccatgtctc caccttcaag acaaggtctg caaagggttt tggggctcga     2580

ggcccagacg tgctgagtcc ggccatggta gccctctcca acaagctgaa gctgaagcga     2640

cagctggagt atgaagagca agccttccag gacctgagcg ggggggaccc acctggtggc     2700

agcacctcac atttgatgtg gaaacggatg aagaacctca ggggtgggag ctgccctttg     2760

atgccggaca agccactgag cgcaaatgta cccaatgata agttcaccca aaaccccatg     2820

aggggcctgg gccatcccct gagacatctg ccgctgccac agcctccatc tgccatcagt     2880

cccggggaga acagcaagag caggttcccc ccacagtgct acgccaccca gtaccaggac     2940

tacagcctgt cgtcagccca caaggtgtca ggcatggcaa gccggctgct cgggccctca     3000

tttgagtcct acctgctgcc cgaactgacc agatatgact gtgaggtgaa cgtgcccgtg     3060

ctgggaagct ccacgctcct gcaaggaggg gacctcctca gagccctgga ccaggccacc     3120

tgagccaggc cttctacctg ggcagcacct ctgccgacgc cgtcccacca gcttcactct     3180

ctccgtctgt ttttgcaact aggtatttct aacgccagca cactatttac aagatggact     3240

tacctggcag acttgcccag gtcaccaagc agtggccttt ttctgagatg ctcactttat     3300

tatccctatt tttaaagtac acaattgttt tacctgttct gaaatgttct taaattttgt     3360

aggatttttt tcctccccac cttcaatgac ttctaattta tattatccat aggtttctct     3420

ccctccttct ccttctcaca cacaactgtc catactaaca agtttggtgc atgtctgttc     3480

ttctgtaggg agaagcttta gcttcatttt actaaaaaga ttcctcgtta ttgttgttgc     3540

caaagagaaa caaaaatgat tttgctttcc aagcttggtt tgtggcgtct ccctcgcaga     3600

gcccttctcg tttctttttt aaactaatca ccatattgta aatttcaggg tttttttttt     3660

tttgtttaag ctgactcttt gctctaattt tggaaaaaaa gaaatgtgaa gggtcaactc     3720

caacgtatgt ggttatctgt gaaagttgca cagcgtggct tttcctaaac tggtgttttt     3780

cccccgcatt tggtggattt tttattatta ttcaaaaaca taactgagtt ttttaaaaga     3840

ggagaaaatt tatatctggg ttaagtgttt atcatatata tgggtacttt gtaatatcta     3900

aaaacttaga aacggaaatg gaatcctgct cacaaaatca ctttaagatc ttttcgaagc     3960

tgttaatttt tcttagtgtt gtggacactg cagacttgtc cagtgctccc acggcctgta     4020

cggacactgt ggaaggcctc cctctgtcgg ctttttgcca tctgtgatat gccataggtg     4080

tgacaatccg agcagtggag tcattcagcg ggagcactgc gcgctatccc ctcacattct     4140

ctatgtacta tgtatgtatg tattattatt attgctgcca agagggtctg atggcacgtt     4200

gtggggtcgg ggggtggggc ggggaagtgc tctaactttt cttaaggttt tgttgctagc     4260

ccttcaagtg cactgagcta tgtgactcgg atggtctttc acacggcaca tttggacatt     4320

tccagaacta ccatgagatg gtttagacgg gaattcatgc aaatgagggg tcaaaaatgg     4380

tatagtgacc ccgtccacgt cctccaagct cacgaccttg gagccccgtg gagctggact     4440

gaggaggagg ctgcacagcg ggagagcagc tggtccagac cagccctgca gcccccactc     4500

agccggcagc cagatggccc cgcaaggcct ccagggatgg cccctagcca caggccctgg     4560

ctgaggtctc tgggtcggtc agtgacatgt aggtaggaag cactgaaaat agtgttccca     4620

gagcactttg caactccctg ggtaagaggg acgacacctc tggtttttca ataccaatta     4680

catggaactt ttctgtaatg ggtacaatga agaagtttct aaaaacacac acaaagcaca     4740

ttgggccaac tatttagtaa gcccggatag acttattgcc aaaaacaaaa aatagctttc     4800

aaaagaaatt taagttctat gagaaattcc ttagtcatgg tgttgcgtaa atcatatttt     4860

agctgcacgg cattacccca cacagggtgg cagaacttga agggttactg acgtgtaaat     4920

gctggtattt gatttcctgt gtgtgttgcc ctggcattaa gggcatttta cccttgcagt     4980

tttactaaaa cactgaaaaa tattccaagc ttcatattaa ccctacctgt caacgtaacg     5040

atttcatgaa cgttattata ttgtcgaatt cctactgaca acattataac tgtatgggag     5100

cttaacttta taaggaaatg tattttgaca ctggtatctt attaaagtat tctgatccta     5160

ccactgaaaa aaaaaaaaaa aaaa                                            5184


<210>  16
<211>  870
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Thr Ala Asp Lys Glu Lys Lys Arg Ser Ser Ser Glu Arg Arg Lys 
1               5                   10                  15      


Glu Lys Ser Arg Asp Ala Ala Arg Cys Arg Arg Ser Lys Glu Thr Glu 
            20                  25                  30          


Val Phe Tyr Glu Leu Ala His Glu Leu Pro Leu Pro His Ser Val Ser 
        35                  40                  45              


Ser His Leu Asp Lys Ala Ser Ile Met Arg Leu Ala Ile Ser Phe Leu 
    50                  55                  60                  


Arg Thr His Lys Leu Leu Ser Ser Val Cys Ser Glu Asn Glu Ser Glu 
65                  70                  75                  80  


Ala Glu Ala Asp Gln Gln Met Asp Asn Leu Tyr Leu Lys Ala Leu Glu 
                85                  90                  95      


Gly Phe Ile Ala Val Val Thr Gln Asp Gly Asp Met Ile Phe Leu Ser 
            100                 105                 110         


Glu Asn Ile Ser Lys Phe Met Gly Leu Thr Gln Val Glu Leu Thr Gly 
        115                 120                 125             


His Ser Ile Phe Asp Phe Thr His Pro Cys Asp His Glu Glu Ile Arg 
    130                 135                 140                 


Glu Asn Leu Ser Leu Lys Asn Gly Ser Gly Phe Gly Lys Lys Ser Lys 
145                 150                 155                 160 


Asp Met Ser Thr Glu Arg Asp Phe Phe Met Arg Met Lys Cys Thr Val 
                165                 170                 175     


Thr Asn Arg Gly Arg Thr Val Asn Leu Lys Ser Ala Thr Trp Lys Val 
            180                 185                 190         


Leu His Cys Thr Gly Gln Val Lys Val Tyr Asn Asn Cys Pro Pro His 
        195                 200                 205             


Asn Ser Leu Cys Gly Tyr Lys Glu Pro Leu Leu Ser Cys Leu Ile Ile 
    210                 215                 220                 


Met Cys Glu Pro Ile Gln His Pro Ser His Met Asp Ile Pro Leu Asp 
225                 230                 235                 240 


Ser Lys Thr Phe Leu Ser Arg His Ser Met Asp Met Lys Phe Thr Tyr 
                245                 250                 255     


Cys Asp Asp Arg Ile Thr Glu Leu Ile Gly Tyr His Pro Glu Glu Leu 
            260                 265                 270         


Leu Gly Arg Ser Ala Tyr Glu Phe Tyr His Ala Leu Asp Ser Glu Asn 
        275                 280                 285             


Met Thr Lys Ser His Gln Asn Leu Cys Thr Lys Gly Gln Val Val Ser 
    290                 295                 300                 


Gly Gln Tyr Arg Met Leu Ala Lys His Gly Gly Tyr Val Trp Leu Glu 
305                 310                 315                 320 


Thr Gln Gly Thr Val Ile Tyr Asn Pro Arg Asn Leu Gln Pro Gln Cys 
                325                 330                 335     


Ile Met Cys Val Asn Tyr Val Leu Ser Glu Ile Glu Lys Asn Asp Val 
            340                 345                 350         


Val Phe Ser Met Asp Gln Thr Glu Ser Leu Phe Lys Pro His Leu Met 
        355                 360                 365             


Ala Met Asn Ser Ile Phe Asp Ser Ser Gly Lys Gly Ala Val Ser Glu 
    370                 375                 380                 


Lys Ser Asn Phe Leu Phe Thr Lys Leu Lys Glu Glu Pro Glu Glu Leu 
385                 390                 395                 400 


Ala Gln Leu Ala Pro Thr Pro Gly Asp Ala Ile Ile Ser Leu Asp Phe 
                405                 410                 415     


Gly Asn Gln Asn Phe Glu Glu Ser Ser Ala Tyr Gly Lys Ala Ile Leu 
            420                 425                 430         


Pro Pro Ser Gln Pro Trp Ala Thr Glu Leu Arg Ser His Ser Thr Gln 
        435                 440                 445             


Ser Glu Ala Gly Ser Leu Pro Ala Phe Thr Val Pro Gln Ala Ala Ala 
    450                 455                 460                 


Pro Gly Ser Thr Thr Pro Ser Ala Thr Ser Ser Ser Ser Ser Cys Ser 
465                 470                 475                 480 


Thr Pro Asn Ser Pro Glu Asp Tyr Tyr Thr Ser Leu Asp Asn Asp Leu 
                485                 490                 495     


Lys Ile Glu Val Ile Glu Lys Leu Phe Ala Met Asp Thr Glu Ala Lys 
            500                 505                 510         


Asp Gln Cys Ser Thr Gln Thr Asp Phe Asn Glu Leu Asp Leu Glu Thr 
        515                 520                 525             


Leu Ala Pro Tyr Ile Pro Met Asp Gly Glu Asp Phe Gln Leu Ser Pro 
    530                 535                 540                 


Ile Cys Pro Glu Glu Arg Leu Leu Ala Glu Asn Pro Gln Ser Thr Pro 
545                 550                 555                 560 


Gln His Cys Phe Ser Ala Met Thr Asn Ile Phe Gln Pro Leu Ala Pro 
                565                 570                 575     


Val Ala Pro His Ser Pro Phe Leu Leu Asp Lys Phe Gln Gln Gln Leu 
            580                 585                 590         


Glu Ser Lys Lys Thr Glu Pro Glu His Arg Pro Met Ser Ser Ile Phe 
        595                 600                 605             


Phe Asp Ala Gly Ser Lys Ala Ser Leu Pro Pro Cys Cys Gly Gln Ala 
    610                 615                 620                 


Ser Thr Pro Leu Ser Ser Met Gly Gly Arg Ser Asn Thr Gln Trp Pro 
625                 630                 635                 640 


Pro Asp Pro Pro Leu His Phe Gly Pro Thr Lys Trp Ala Val Gly Asp 
                645                 650                 655     


Gln Arg Thr Glu Phe Leu Gly Ala Ala Pro Leu Gly Pro Pro Val Ser 
            660                 665                 670         


Pro Pro His Val Ser Thr Phe Lys Thr Arg Ser Ala Lys Gly Phe Gly 
        675                 680                 685             


Ala Arg Gly Pro Asp Val Leu Ser Pro Ala Met Val Ala Leu Ser Asn 
    690                 695                 700                 


Lys Leu Lys Leu Lys Arg Gln Leu Glu Tyr Glu Glu Gln Ala Phe Gln 
705                 710                 715                 720 


Asp Leu Ser Gly Gly Asp Pro Pro Gly Gly Ser Thr Ser His Leu Met 
                725                 730                 735     


Trp Lys Arg Met Lys Asn Leu Arg Gly Gly Ser Cys Pro Leu Met Pro 
            740                 745                 750         


Asp Lys Pro Leu Ser Ala Asn Val Pro Asn Asp Lys Phe Thr Gln Asn 
        755                 760                 765             


Pro Met Arg Gly Leu Gly His Pro Leu Arg His Leu Pro Leu Pro Gln 
    770                 775                 780                 


Pro Pro Ser Ala Ile Ser Pro Gly Glu Asn Ser Lys Ser Arg Phe Pro 
785                 790                 795                 800 


Pro Gln Cys Tyr Ala Thr Gln Tyr Gln Asp Tyr Ser Leu Ser Ser Ala 
                805                 810                 815     


His Lys Val Ser Gly Met Ala Ser Arg Leu Leu Gly Pro Ser Phe Glu 
            820                 825                 830         


Ser Tyr Leu Leu Pro Glu Leu Thr Arg Tyr Asp Cys Glu Val Asn Val 
        835                 840                 845             


Pro Val Leu Gly Ser Ser Thr Leu Leu Gln Gly Gly Asp Leu Leu Arg 
    850                 855                 860                 


Ala Leu Asp Gln Ala Thr 
865                 870 


<210>  17
<211>  1208
<212>  DNA
<213>  Homo sapiens

<400>  17
aaagcgagag tgagtgggac cggaggggcg gggcatcata tgggcggggc tgaggcgagg       60

ccccggcggc catcttgagc cccgcctttt acttcggccc gcttcttctg gtcactccgc      120

caccgtagaa tcgcctacca tttggtgcaa gcaaaaagca atcagcaatt ggacaggaaa      180

agaatggcat tgaagcagat ttccagcaac aagtgctttg ggggattgca gaaagttttt      240

gaacatgaca gtgttgaact aaactgcaaa atgaaatttg ctgtctactt accaccaaag      300

gcagaaacag gaaagtgccc tgcactgtat tggctctcag gtttaacttg cacagagcaa      360

aattttatat caaaatctgg ttatcatcag tctgcttcag aacatggtct tgttgtcatt      420

gctccagata ccagccctcg tggctgcaat attaaaggtg aagatgagag ctgggacttt      480

ggcactggtg ctggatttta tgttgatgcc actgaagatc cttggaaaac caactacaga      540

atgtactctt atgtcacaga ggagcttccc caactcataa atgccaattt tccagtggat      600

ccccaaagga tgtctatttt tggccactcc atgggaggtc atggagctct gatctgtgct      660

ttgaaaaatc ctggaaaata caaatctgtg tcagcatttg ctccaatttg caaccctgta      720

ctctgtccct ggggcaaaaa agcctttagt ggatatttgg gaacagatca aagtaaatgg      780

aaggcttatg atgctaccca ccttgtgaaa tcctatccag gatctcagct ggacatacta      840

attgatcaag ggaaagatga ccagtttctt ttagatggac agttactccc tgataacttc      900

atagctgcct gtacagaaaa gaaaatcccc gttgtttttc gattgcaaga gggttatgat      960

catagctact acttcattgc aacctttatt actgaccaca tcagacatca tgctaaatac     1020

ctgaatgcat gaaaaaactc caaataagag aatctcttca ggattataaa agttgtaaaa     1080

tgcaactgta ttgctgagca aaaaaaaaaa aaattcaaaa cattggattt tatagtgcta     1140

aaagggcttt attctatagt tgaatcacct ctgaataaag atataaaacc taaaaaaaaa     1200

aaaaaaaa                                                              1208


<210>  18
<211>  282
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ala Leu Lys Gln Ile Ser Ser Asn Lys Cys Phe Gly Gly Leu Gln 
1               5                   10                  15      


Lys Val Phe Glu His Asp Ser Val Glu Leu Asn Cys Lys Met Lys Phe 
            20                  25                  30          


Ala Val Tyr Leu Pro Pro Lys Ala Glu Thr Gly Lys Cys Pro Ala Leu 
        35                  40                  45              


Tyr Trp Leu Ser Gly Leu Thr Cys Thr Glu Gln Asn Phe Ile Ser Lys 
    50                  55                  60                  


Ser Gly Tyr His Gln Ser Ala Ser Glu His Gly Leu Val Val Ile Ala 
65                  70                  75                  80  


Pro Asp Thr Ser Pro Arg Gly Cys Asn Ile Lys Gly Glu Asp Glu Ser 
                85                  90                  95      


Trp Asp Phe Gly Thr Gly Ala Gly Phe Tyr Val Asp Ala Thr Glu Asp 
            100                 105                 110         


Pro Trp Lys Thr Asn Tyr Arg Met Tyr Ser Tyr Val Thr Glu Glu Leu 
        115                 120                 125             


Pro Gln Leu Ile Asn Ala Asn Phe Pro Val Asp Pro Gln Arg Met Ser 
    130                 135                 140                 


Ile Phe Gly His Ser Met Gly Gly His Gly Ala Leu Ile Cys Ala Leu 
145                 150                 155                 160 


Lys Asn Pro Gly Lys Tyr Lys Ser Val Ser Ala Phe Ala Pro Ile Cys 
                165                 170                 175     


Asn Pro Val Leu Cys Pro Trp Gly Lys Lys Ala Phe Ser Gly Tyr Leu 
            180                 185                 190         


Gly Thr Asp Gln Ser Lys Trp Lys Ala Tyr Asp Ala Thr His Leu Val 
        195                 200                 205             


Lys Ser Tyr Pro Gly Ser Gln Leu Asp Ile Leu Ile Asp Gln Gly Lys 
    210                 215                 220                 


Asp Asp Gln Phe Leu Leu Asp Gly Gln Leu Leu Pro Asp Asn Phe Ile 
225                 230                 235                 240 


Ala Ala Cys Thr Glu Lys Lys Ile Pro Val Val Phe Arg Leu Gln Glu 
                245                 250                 255     


Gly Tyr Asp His Ser Tyr Tyr Phe Ile Ala Thr Phe Ile Thr Asp His 
            260                 265                 270         


Ile Arg His His Ala Lys Tyr Leu Asn Ala 
        275                 280         


<210>  19
<211>  2359
<212>  DNA
<213>  Homo sapiens

<400>  19
tgttggccta ctggaaaaaa aaaataaatt atttttgtta aggcaagcat tggtgtgttc       60

tttaacttgc tacttggaga cctagtgtcc agtctggaca gaatgcacag agaccagcct      120

cacctggaat gcagccagac tcgatgtccc tcagcacaca cagctcctgg ccacagactg      180

cccatagaac tgtctgcacc caaaccccat ggccttttca tgcacggaga caggcctctg      240

gatgtgcagc cttgccaccc cctgccccaa tcctccctga gagctcctgc gtcagtgccc      300

tgggctggtg agggagaagc ctgtctgcac ctgcctaatt ccagctcctc caggaagcaa      360

gggcttgttt gtcagagctg cagggttggc cactcggtgg ggaggagtca gccaggatta      420

gagagcctgc ccctaatccg gcctgctggg gtttacaagg atcagagctg ctgataatga      480

acctcattaa gggggagcag gagcctcaat ccgatttggt cttctctttg acatcttcac      540

tctgctcaga tggcctgggt gctatgtgga gcaggtggga tgccaaggcc actcctgcta      600

tggggcagct ggggctgggg agggatggca gtctccctgc atgtttccct cgacctcttt      660

agctgcagcg ccttgctggg ctcctgggtt ggactccctc tctgtgcccc tgctccaggc      720

acccattggc tccatcctcc tggttgtgct ctgcaccccc tgctcccttg ggctggccct      780

ggctgggggc ctgagagaca gacaggaacc cacaatcagg aggcaaccct ggcctgcaag      840

aggaagacag aggctcccag ggccggtgcc ctgtgtgccc actgcaccaa ggccgctgaa      900

taagcctgcc cttcaccccc taagggctcc ttgcccaatg ccaagtgctg gggatttctg      960

tcagcaagcc ctgtggctcc agtgacggta tttctaaagc caaacttagt tacctagaat     1020

tagcgccatg ttggaaacac tgtcgcagca gcccgggctg cacagtgtgt agcccagcct     1080

ccaggtccac ggagtggtgt ggacctccca cctcacagct gcctctggca gccaagcctc     1140

ttttcgcccg gccccagccc ctctggttga taaacgggtg ggcctcctca gcagcgtggc     1200

tgcctttcac cttgatttcc ccagggctct cggcaacatc gataaaccag cctcgcccac     1260

cagctgggcc ctcccccacc cagtctgcca ggctgggagc tggagcttgc tgagtcttga     1320

atgcccttct agatggcttc tctagaggct ctcctggcaa gagagggtcc caaggggagc     1380

cctgcaaagc aaaggctcct tgtctggggc gggatagaga atctcgcctc tgtctggtgt     1440

gttacctact gggggcacag gaacaatttc ctcaaggaga cagtggcatg gagctttgaa     1500

agacgagtag gtgttagcaa ggaaataagg aggaacgggg gttacgggca gaggagaaag     1560

cacatgccaa gtcagcaaag aaaagtagaa ttcgaaaact ttttaaaaat attactaagg     1620

attttcacaa tgctgcactg ggctagaaac tgaagctaaa acagatacgt ggtccctgct     1680

gctatggggc ttccgttcta gaggcaagga caggttgtga tgagggttct gaaggataga     1740

gaccaagcag ggagggtgtt gaggaggctt ctgcgagacc tgaaggatgg gaagccagga     1800

agtgggaggg gtgggggtcc aggctggagg ggcccaatgt aggtgtagag ggactacagc     1860

cctgaggggc tgctccatgc ggcattcttg gaggtccaag aggggcagcg ccaccttggg     1920

ccaggctcct ctccagcagc cttggtatgg ggtgggggtg ggaagacccc tgatgcagcc     1980

tgtcctctgg gtgtgggggt ggaggagagg gctccagggg acccagccag ccttgaccct     2040

ggaggaaagt caggtgggct cggagagagc cctcaaattt gggccctggg tcagggtggg     2100

gtcaagtcca gccttgaaga gaatggactc tggaatctga cgtctgggtt tgaatccagc     2160

ttccaacact cactggctgt gtgactttgg gcaagataac ttatcccctt gtccccatgt     2220

gtcattggag ataaactacc cacctaccag attgttgtac tatgctgggc aaacactaag     2280

tgcttaataa tggtagccca ctgctcaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2340

aaaaaaaaaa aaaaaaaaa                                                  2359


<210>  20
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  20

Met His Arg Asp Gln Pro His Leu Glu Cys Ser Gln Thr Arg Cys Pro 
1               5                   10                  15      


Ser Ala His Thr Ala Pro Gly His Arg Leu Pro Ile Glu Leu Ser Ala 
            20                  25                  30          


Pro Lys Pro His Gly Leu Phe Met His Gly Asp Arg Pro Leu Asp Val 
        35                  40                  45              


Gln Pro Cys His Pro Leu Pro Gln Ser Ser Leu Arg Ala Pro Ala Ser 
    50                  55                  60                  


Val Pro Trp Ala Gly Glu Gly Glu Ala Cys Leu His Leu Pro Asn Ser 
65                  70                  75                  80  


Ser Ser Ser Arg Lys Gln Gly Leu Val Cys Gln Ser Cys Arg Val Gly 
                85                  90                  95      


His Ser Val Gly Arg Ser Gln Pro Gly Leu Glu Ser Leu Pro Leu Ile 
            100                 105                 110         


Arg Pro Ala Gly Val Tyr Lys Asp Gln Ser Cys 
        115                 120             


<210>  21
<211>  3665
<212>  DNA
<213>  Homo sapiens

<400>  21
tttcaaacag cggaacaaac tgaaagctcc ggtgccagac cccacccccg gccccggccc       60

gggaccccct cccctcccgg gatcccccgg ggttcccacc ccgcccgcac cgccggggac      120

ccggccggtc cggcgcgagc ccccgtccgg ggccctggct cggcccccag gttggaggag      180

cccggagccc gccttcggag ctacggccta acggcggcgg cgactgcagt ctggagggtc      240

cacacttgtg attctcaatg gagagtgaaa acgcagattc ataatgaaaa ctagcccccg      300

tcggccactg attctcaaaa gacggaggct gccccttcct gttcaaaatg ccccaagtga      360

aacatcagag gaggaaccta agagatcccc tgcccaacag gagtctaatc aagcagaggc      420

ctccaaggaa gtggcagagt ccaactcttg caagtttcca gctgggatca agattattaa      480

ccaccccacc atgcccaaca cgcaagtagt ggccatcccc aacaatgcta atattcacag      540

catcatcaca gcactgactg ccaagggaaa agagagtggc agtagtgggc ccaacaaatt      600

catcctcatc agctgtgggg gagccccaac tcagcctcca ggactccggc ctcaaaccca      660

aaccagctat gatgccaaaa ggacagaagt gaccctggag accttgggac caaaacctgc      720

agctagggat gtgaatcttc ctagaccacc tggagccctt tgcgagcaga aacgggagac      780

ctgtgcagat ggtgaggcag caggctgcac tatcaacaat agcctatcca acatccagtg      840

gcttcgaaag atgagttctg atggactggg ctcccgcagc atcaagcaag agatggagga      900

aaaggagaat tgtcacctgg agcagcgaca ggttaaggtt gaggagcctt cgagaccatc      960

agcgtcctgg cagaactctg tgtctgagcg gccaccctac tcttacatgg ccatgataca     1020

attcgccatc aacagcactg agaggaagcg catgactttg aaagacatct atacgtggat     1080

tgaggaccac tttccctact ttaagcacat tgccaagcca ggctggaaga actccatccg     1140

ccacaacctt tccctgcacg acatgtttgt ccgggagacg tctgccaatg gcaaggtctc     1200

cttctggacc attcacccca gtgccaaccg ctacttgaca ttggaccagg tgtttaagcc     1260

actggaccca gggtctccac aattgcccga gcacttggaa tcacagcaga aacgaccgaa     1320

tccagagctc cgccggaaca tgaccatcaa aaccgaactc cccctgggcg cacggcggaa     1380

gatgaagcca ctgctaccac gggtcagctc atacctggta cctatccagt tcccggtgaa     1440

ccagtcactg gtgttgcagc cctcggtgaa ggtgccattg cccctggcgg cttccctcat     1500

gagctcagag cttgcccgcc atagcaagcg agtccgcatt gcccccaagg tttttgggga     1560

acaggtggtg tttggttaca tgagtaagtt ctttagtggc gatctgcgag attttggtac     1620

acccatcacc agcttgttta attttatctt tctttgttta tcagtgctgc tagctgagga     1680

ggggatagct cctctttctt ctgcaggacc agggaaagag gagaaactcc tgtttggaga     1740

agggttttct cctttgcttc cagttcagac tatcaaggag gaagaaatcc agcctgggga     1800

ggaaatgcca cacttagcga gacccatcaa agtggagagc cctcccttgg aagagtggcc     1860

ctccccggcc ccatctttca aagaggaatc atctcactcc tgggaggatt cgtcccaatc     1920

tcccacccca agacccaaga agtcctacag tgggcttagg tccccaaccc ggtgtgtctc     1980

ggaaatgctt gtgattcaac acagggagag gagggagagg agccggtctc ggaggaaaca     2040

gcatctactg cctccctgtg tggatgagcc ggagctgctc ttctcagagg ggcccagtac     2100

ttcccgctgg gccgcagagc tcccgttccc agcagactcc tctgaccctg cctcccagct     2160

cagctactcc caggaagtgg gaggaccttt taagacaccc attaaggaaa cgctgcccat     2220

ctcctccacc ccgagcaaat ctgtcctccc cagaacccct gaatcctgga ggctcacgcc     2280

cccagccaaa gtagggggac tggatttcag cccagtacaa acctcccagg gtgcctctga     2340

ccccttgcct gaccccctgg ggctgatgga tctcagcacc actcccttgc aaagtgctcc     2400

cccccttgaa tcaccgcaaa ggctcctcag ttcagaaccc ttagacctca tctccgtccc     2460

ctttggcaac tcttctccct cagatataga cgtccccaag ccaggctccc cggagccaca     2520

ggtttctggc cttgcagcca atcgttctct gacagaaggc ctggtcctgg acacaatgaa     2580

tgacagcctc agcaagatcc tgctggacat cagctttcct ggcctggacg aggacccact     2640

gggccctgac aacatcaact ggtcccagtt tattcctgag ctacagtaga gccctgccct     2700

tgcccctgtg ctcaagctgt ccaccatccc gggcactcca aggctcagtg caccccaagc     2760

ctctgagtga ggacagcagg cagggactgt tctgctcctc atagctccct gctgcctgat     2820

tatgcaaaag tagcagtcac accctagcca ctgctgggac cttgtgttcc ccaagagtat     2880

ctgattcctc tgctgtccct gccaggagct gaagggtggg aacaacaaag gcaatggtga     2940

aaagagatta ggaacccccc agcctgtttc cattctctgc ccagcagtct cttaccttcc     3000

ctgatctttg cagggtggtc cgtgtaaata gtataaattc tccaaattat cctctaatta     3060

taaatgtaag cttatttcct tagatcatta tccagagact gccagaaggt gggtaggatg     3120

acctggggtt tcaattgact tctgttcctt gcttttagtt ttgatagaag ggaagacctg     3180

cagtgcacgg tttcttccag gctgaggtac ctggatcttg ggttcttcac tgcagggacc     3240

cagacaagtg gatctgcttg ccagagtcct ttttgcccct ccctgccacc tccccgtgtt     3300

tccaagtcag ctttcctgca agaagaaatc ctggttaaaa aagtcttttg tattgggtca     3360

ggagttgaat ttggggtggg aggatggatg caactgaagc agagtgtggg tgcccagatg     3420

tgcgctatta gatgtttctc tgataatgtc cccaatcata ccagggagac tggcattgac     3480

gagaactcag gtggaggctt gagaaggccg aaagggcccc tgacctgcct ggcttcctta     3540

gcttgcccct cagctttgca aagagccacc ctaggcccca gctgaccgca tgggtgtgag     3600

ccagcttgag aacactaact actcaataaa agcgaaggtg gacatgaaaa aaaaaaaaaa     3660

aaaaa                                                                 3665


<210>  22
<211>  801
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Lys Thr Ser Pro Arg Arg Pro Leu Ile Leu Lys Arg Arg Arg Leu 
1               5                   10                  15      


Pro Leu Pro Val Gln Asn Ala Pro Ser Glu Thr Ser Glu Glu Glu Pro 
            20                  25                  30          


Lys Arg Ser Pro Ala Gln Gln Glu Ser Asn Gln Ala Glu Ala Ser Lys 
        35                  40                  45              


Glu Val Ala Glu Ser Asn Ser Cys Lys Phe Pro Ala Gly Ile Lys Ile 
    50                  55                  60                  


Ile Asn His Pro Thr Met Pro Asn Thr Gln Val Val Ala Ile Pro Asn 
65                  70                  75                  80  


Asn Ala Asn Ile His Ser Ile Ile Thr Ala Leu Thr Ala Lys Gly Lys 
                85                  90                  95      


Glu Ser Gly Ser Ser Gly Pro Asn Lys Phe Ile Leu Ile Ser Cys Gly 
            100                 105                 110         


Gly Ala Pro Thr Gln Pro Pro Gly Leu Arg Pro Gln Thr Gln Thr Ser 
        115                 120                 125             


Tyr Asp Ala Lys Arg Thr Glu Val Thr Leu Glu Thr Leu Gly Pro Lys 
    130                 135                 140                 


Pro Ala Ala Arg Asp Val Asn Leu Pro Arg Pro Pro Gly Ala Leu Cys 
145                 150                 155                 160 


Glu Gln Lys Arg Glu Thr Cys Ala Asp Gly Glu Ala Ala Gly Cys Thr 
                165                 170                 175     


Ile Asn Asn Ser Leu Ser Asn Ile Gln Trp Leu Arg Lys Met Ser Ser 
            180                 185                 190         


Asp Gly Leu Gly Ser Arg Ser Ile Lys Gln Glu Met Glu Glu Lys Glu 
        195                 200                 205             


Asn Cys His Leu Glu Gln Arg Gln Val Lys Val Glu Glu Pro Ser Arg 
    210                 215                 220                 


Pro Ser Ala Ser Trp Gln Asn Ser Val Ser Glu Arg Pro Pro Tyr Ser 
225                 230                 235                 240 


Tyr Met Ala Met Ile Gln Phe Ala Ile Asn Ser Thr Glu Arg Lys Arg 
                245                 250                 255     


Met Thr Leu Lys Asp Ile Tyr Thr Trp Ile Glu Asp His Phe Pro Tyr 
            260                 265                 270         


Phe Lys His Ile Ala Lys Pro Gly Trp Lys Asn Ser Ile Arg His Asn 
        275                 280                 285             


Leu Ser Leu His Asp Met Phe Val Arg Glu Thr Ser Ala Asn Gly Lys 
    290                 295                 300                 


Val Ser Phe Trp Thr Ile His Pro Ser Ala Asn Arg Tyr Leu Thr Leu 
305                 310                 315                 320 


Asp Gln Val Phe Lys Pro Leu Asp Pro Gly Ser Pro Gln Leu Pro Glu 
                325                 330                 335     


His Leu Glu Ser Gln Gln Lys Arg Pro Asn Pro Glu Leu Arg Arg Asn 
            340                 345                 350         


Met Thr Ile Lys Thr Glu Leu Pro Leu Gly Ala Arg Arg Lys Met Lys 
        355                 360                 365             


Pro Leu Leu Pro Arg Val Ser Ser Tyr Leu Val Pro Ile Gln Phe Pro 
    370                 375                 380                 


Val Asn Gln Ser Leu Val Leu Gln Pro Ser Val Lys Val Pro Leu Pro 
385                 390                 395                 400 


Leu Ala Ala Ser Leu Met Ser Ser Glu Leu Ala Arg His Ser Lys Arg 
                405                 410                 415     


Val Arg Ile Ala Pro Lys Val Phe Gly Glu Gln Val Val Phe Gly Tyr 
            420                 425                 430         


Met Ser Lys Phe Phe Ser Gly Asp Leu Arg Asp Phe Gly Thr Pro Ile 
        435                 440                 445             


Thr Ser Leu Phe Asn Phe Ile Phe Leu Cys Leu Ser Val Leu Leu Ala 
    450                 455                 460                 


Glu Glu Gly Ile Ala Pro Leu Ser Ser Ala Gly Pro Gly Lys Glu Glu 
465                 470                 475                 480 


Lys Leu Leu Phe Gly Glu Gly Phe Ser Pro Leu Leu Pro Val Gln Thr 
                485                 490                 495     


Ile Lys Glu Glu Glu Ile Gln Pro Gly Glu Glu Met Pro His Leu Ala 
            500                 505                 510         


Arg Pro Ile Lys Val Glu Ser Pro Pro Leu Glu Glu Trp Pro Ser Pro 
        515                 520                 525             


Ala Pro Ser Phe Lys Glu Glu Ser Ser His Ser Trp Glu Asp Ser Ser 
    530                 535                 540                 


Gln Ser Pro Thr Pro Arg Pro Lys Lys Ser Tyr Ser Gly Leu Arg Ser 
545                 550                 555                 560 


Pro Thr Arg Cys Val Ser Glu Met Leu Val Ile Gln His Arg Glu Arg 
                565                 570                 575     


Arg Glu Arg Ser Arg Ser Arg Arg Lys Gln His Leu Leu Pro Pro Cys 
            580                 585                 590         


Val Asp Glu Pro Glu Leu Leu Phe Ser Glu Gly Pro Ser Thr Ser Arg 
        595                 600                 605             


Trp Ala Ala Glu Leu Pro Phe Pro Ala Asp Ser Ser Asp Pro Ala Ser 
    610                 615                 620                 


Gln Leu Ser Tyr Ser Gln Glu Val Gly Gly Pro Phe Lys Thr Pro Ile 
625                 630                 635                 640 


Lys Glu Thr Leu Pro Ile Ser Ser Thr Pro Ser Lys Ser Val Leu Pro 
                645                 650                 655     


Arg Thr Pro Glu Ser Trp Arg Leu Thr Pro Pro Ala Lys Val Gly Gly 
            660                 665                 670         


Leu Asp Phe Ser Pro Val Gln Thr Ser Gln Gly Ala Ser Asp Pro Leu 
        675                 680                 685             


Pro Asp Pro Leu Gly Leu Met Asp Leu Ser Thr Thr Pro Leu Gln Ser 
    690                 695                 700                 


Ala Pro Pro Leu Glu Ser Pro Gln Arg Leu Leu Ser Ser Glu Pro Leu 
705                 710                 715                 720 


Asp Leu Ile Ser Val Pro Phe Gly Asn Ser Ser Pro Ser Asp Ile Asp 
                725                 730                 735     


Val Pro Lys Pro Gly Ser Pro Glu Pro Gln Val Ser Gly Leu Ala Ala 
            740                 745                 750         


Asn Arg Ser Leu Thr Glu Gly Leu Val Leu Asp Thr Met Asn Asp Ser 
        755                 760                 765             


Leu Ser Lys Ile Leu Leu Asp Ile Ser Phe Pro Gly Leu Asp Glu Asp 
    770                 775                 780                 


Pro Leu Gly Pro Asp Asn Ile Asn Trp Ser Gln Phe Ile Pro Glu Leu 
785                 790                 795                 800 


Gln 
    


<210>  23
<211>  4350
<212>  DNA
<213>  Homo sapiens

<400>  23
agttgaggga ttgacacaaa tggtcaggcg gcggcggcgg agaaggaggc ggaggcgcag       60

gggggagccg agcccgctgg gctgcggaga gttgcgctct ctacggggcc gcggccacta      120

gcgcggcgcc gccagccggg agccagcgag ccgagggcca ggaaggcggg acacgacccc      180

ggcgcgccct agccacccgg gttctccccg ccgcccgcgc ttcatgaatc gcaagtttcc      240

gcggcggcgg cggctgcggt acgcagaaca ggagccgggg gagcgggccg aaagcggctt      300

gggctcgacg gagggcaccc gcgcagaggt ctccctggcc gcagggggag ccgccgccgg      360

ccgtgcccct ggcagcccca gcggagcggc gccaagagag gagccgagaa agtatggctg      420

aggaggaggc gcctaagaag tcccgggccg ccggcggtgg cgcgagctgg gaactttgtg      480

ccggggcgct ctcggcccgg ctggcggagg agggcagcgg ggacgccggt ggccgccgcc      540

gcccgccagt tgacccccgg cgattggcgc gccagctgct gctgctgctt tggctgctgg      600

aggctccgct gctgctgggg gtccgggccc aggcggcggg ccaggggcca ggccaggggc      660

ccgggccggg gcagcaaccg ccgccgccgc ctcagcagca acagagcggg cagcagtaca      720

acggcgagcg gggcatctcc gtcccggacc acggctattg ccagcccatc tccatcccgc      780

tgtgcacgga catcgcgtac aaccagacca tcatgcccaa cctgctgggc cacacgaacc      840

aggaggacgc gggcctggag gtgcaccagt tctaccctct agtgaaagtg cagtgttccg      900

ctgagctcaa gttcttcctg tgctccatgt acgcgcccgt gtgcaccgtg ctagagcagg      960

cgctgccgcc ctgccgctcc ctgtgcgagc gcgcgcgcca gggctgcgag gcgctcatga     1020

acaagttcgg cttccagtgg ccagacacgc tcaagtgtga gaagttcccg gtgcacggcg     1080

ccggcgagct gtgcgtgggc cagaacacgt ccgacaaggg caccccgacg ccctcgctgc     1140

ttccagagtt ctggaccagc aaccctcagc acggcggcgg agggcaccgt ggcggcttcc     1200

cggggggcgc cggcgcgtcg gagcgaggca agttctcctg cccgcgcgcc ctcaaggtgc     1260

cctcctacct caactaccac ttcctggggg agaaggactg cggcgcacct tgtgagccga     1320

ccaaggtgta tgggctcatg tacttcgggc ccgaggagct gcgcttctcg cgcacctgga     1380

ttggcatttg gtcagtgctg tgctgcgcct ccacgctctt cacggtgctt acgtacctgg     1440

tggacatgcg gcgcttcagc tacccggagc ggcccatcat cttcttgtcc ggctgttaca     1500

cggccgtggc cgtggcctac atcgccggct tcctcctgga agaccgagtg gtgtgtaatg     1560

acaagttcgc cgaggacggg gcacgcactg tggcgcaggg caccaagaag gagggctgca     1620

ccatcctctt catgatgctc tacttcttca gcatggccag ctccatctgg tgggtgatcc     1680

tgtcgctcac ctggttcctg gcggctggca tgaagtgggg ccacgaggcc atcgaagcca     1740

actcacagta ttttcacctg gccgcctggg ctgtgccggc catcaagacc atcaccatcc     1800

tggcgctggg ccaggtggac ggcgatgtgc tgagcggagt gtgcttcgtg gggcttaaca     1860

acgtggacgc gctgcgtggc ttcgtgctgg cgcccctctt cgtgtacctg tttatcggca     1920

cgtcctttct gctggccggc tttgtgtcgc tcttccgcat ccgcaccatc atgaagcacg     1980

atggcaccaa gaccgagaag ctggagaagc tcatggtgcg cattggcgtc ttcagcgtgc     2040

tgtacactgt gccagccacc atcgtcatcg cctgctactt ctacgagcag gccttccggg     2100

accagtggga acgcagctgg gtggcccaga gctgcaagag ctacgctatc ccctgccctc     2160

acctccaggc gggcggaggc gccccgccgc acccgcccat gagcccggac ttcacggtct     2220

tcatgattaa gtaccttatg acgctgatcg tgggcatcac gtcgggcttc tggatctggt     2280

ccggcaagac cctcaactcc tggaggaagt tctacacgag gctcaccaac agcaaacaag     2340

gggagactac agtctgagac ccggggctca gcccatgccc aggcctcggc cggggcgcag     2400

cgatccccca aagccagcgc cgtggagttc gtgccaatcc tgacatctcg aggtttcctc     2460

actagacaac tctctttcgc aggctccttt gaacaactca gctcctgcaa aagcttccgt     2520

ccctgaggca aaaggacacg agggcccgac tgccagaggg aggatggaca gacctcttgc     2580

cctcacactc tggtaccagg actgttcgct tttatgattg taaatagcct gtgtaagatt     2640

tttgtaagta tatttgtatt taaatgacga ccgatcacgc gtttttcttt ttcaaaagtt     2700

tttaattatt tagggcggtt taaccatttg aggcttttcc ttcttgccct tttcggagta     2760

ttgcaaagga gctaaaactg gtgtgcaacc gcacagcgct cctggtcgtc ctcgcgcgcc     2820

tctccctacc acgggtgctc gggacggctg ggcgccagct ccggggcgag ttcagcactg     2880

cggggtgcga ctagggctgc gctgccaggg tcacttcccg cctcctcctt ttgccccctc     2940

cccctccttc tgtcccctcc ctttctttcc tggcttgagg taggggctct taaggtacag     3000

aactccacaa accttccaaa tctggaggag ggcccccata cattacaatt cctcccttgc     3060

tcggcggtgg attgcgaagg cccgtccctt cgacttcctg aagctggatt tttaactgtc     3120

cagaactttc ctccaacttc atgggggccc acgggtgtgg gcgctggcag tctcagcctc     3180

cctccacggt caccttcaac gcccagacac tcccttctcc caccttagtt ggttacaggg     3240

tgagtgagat aaccaatgcc aaactttttg aagtctaatt tttgaggggt gagctcattt     3300

cattctctag tgtctaaaac ctggtatggg tttggccagc gtcatggaaa gatgtggtta     3360

ctgagatttg ggaagaagca tgaagctttg tgtgggttgg aagagactga agatatgggt     3420

tataaaatgt taattctaat tgcatacgga tgcctggcaa ccttgccttt gagaatgaga     3480

cagcctgcgc ttagatttta ccggtctgta aaatggaaat gttgaggtca cctggaaagc     3540

tttgttaagg agttgatgtt tgctttcctt aacaagacag caaaacgtaa acagaaattg     3600

aaaacttgaa ggatatttca gtgtcatgga cttcctcaaa atgaagtgct attttcttat     3660

ttttaatcaa ataactagac atatatcaga aactttaaaa tgtaaaagtt gtacactttc     3720

aacattttat tacgattatt attcagcagc acattctgag gggggaacaa ttcacaccac     3780

caataataac ctggtaagat ttcaggaggt aaagaaggtg gaataattga cggggagata     3840

gcgcctgaaa taaacaaaat atgggcatgc atgctaaagg gaaaatgtgt gcaggtctac     3900

tgcattaaat cctgtgtgct cctcttttgg atttacagaa atgtgtcaaa tgtaaatctt     3960

tcaaagccat ttaaaaatat tcactttagt tctctgtgaa gaagaggaga aaagcaatcc     4020

tcctgattgt attgttttaa actttaagaa tttatcaaaa tgccggtact taggacctaa     4080

atttatctat gtctgtcata cgctaaaatg atattggtct ttgaatttgg tatacattta     4140

ttctgttcac tatcacaaaa tcatctatat ttatagagga atagaagttt atatatatat     4200

aataccatat ttttaatttc acaaataaaa aattcaaagt tttgtacaaa attatatgga     4260

ttttgtgcct gaaaataata gagcttgagc tgtctgaact attttacatt ttatggtgtc     4320

tcatagccaa tcccacagtg taaaaattca                                      4350


<210>  24
<211>  647
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ala Glu Glu Glu Ala Pro Lys Lys Ser Arg Ala Ala Gly Gly Gly 
1               5                   10                  15      


Ala Ser Trp Glu Leu Cys Ala Gly Ala Leu Ser Ala Arg Leu Ala Glu 
            20                  25                  30          


Glu Gly Ser Gly Asp Ala Gly Gly Arg Arg Arg Pro Pro Val Asp Pro 
        35                  40                  45              


Arg Arg Leu Ala Arg Gln Leu Leu Leu Leu Leu Trp Leu Leu Glu Ala 
    50                  55                  60                  


Pro Leu Leu Leu Gly Val Arg Ala Gln Ala Ala Gly Gln Gly Pro Gly 
65                  70                  75                  80  


Gln Gly Pro Gly Pro Gly Gln Gln Pro Pro Pro Pro Pro Gln Gln Gln 
                85                  90                  95      


Gln Ser Gly Gln Gln Tyr Asn Gly Glu Arg Gly Ile Ser Val Pro Asp 
            100                 105                 110         


His Gly Tyr Cys Gln Pro Ile Ser Ile Pro Leu Cys Thr Asp Ile Ala 
        115                 120                 125             


Tyr Asn Gln Thr Ile Met Pro Asn Leu Leu Gly His Thr Asn Gln Glu 
    130                 135                 140                 


Asp Ala Gly Leu Glu Val His Gln Phe Tyr Pro Leu Val Lys Val Gln 
145                 150                 155                 160 


Cys Ser Ala Glu Leu Lys Phe Phe Leu Cys Ser Met Tyr Ala Pro Val 
                165                 170                 175     


Cys Thr Val Leu Glu Gln Ala Leu Pro Pro Cys Arg Ser Leu Cys Glu 
            180                 185                 190         


Arg Ala Arg Gln Gly Cys Glu Ala Leu Met Asn Lys Phe Gly Phe Gln 
        195                 200                 205             


Trp Pro Asp Thr Leu Lys Cys Glu Lys Phe Pro Val His Gly Ala Gly 
    210                 215                 220                 


Glu Leu Cys Val Gly Gln Asn Thr Ser Asp Lys Gly Thr Pro Thr Pro 
225                 230                 235                 240 


Ser Leu Leu Pro Glu Phe Trp Thr Ser Asn Pro Gln His Gly Gly Gly 
                245                 250                 255     


Gly His Arg Gly Gly Phe Pro Gly Gly Ala Gly Ala Ser Glu Arg Gly 
            260                 265                 270         


Lys Phe Ser Cys Pro Arg Ala Leu Lys Val Pro Ser Tyr Leu Asn Tyr 
        275                 280                 285             


His Phe Leu Gly Glu Lys Asp Cys Gly Ala Pro Cys Glu Pro Thr Lys 
    290                 295                 300                 


Val Tyr Gly Leu Met Tyr Phe Gly Pro Glu Glu Leu Arg Phe Ser Arg 
305                 310                 315                 320 


Thr Trp Ile Gly Ile Trp Ser Val Leu Cys Cys Ala Ser Thr Leu Phe 
                325                 330                 335     


Thr Val Leu Thr Tyr Leu Val Asp Met Arg Arg Phe Ser Tyr Pro Glu 
            340                 345                 350         


Arg Pro Ile Ile Phe Leu Ser Gly Cys Tyr Thr Ala Val Ala Val Ala 
        355                 360                 365             


Tyr Ile Ala Gly Phe Leu Leu Glu Asp Arg Val Val Cys Asn Asp Lys 
    370                 375                 380                 


Phe Ala Glu Asp Gly Ala Arg Thr Val Ala Gln Gly Thr Lys Lys Glu 
385                 390                 395                 400 


Gly Cys Thr Ile Leu Phe Met Met Leu Tyr Phe Phe Ser Met Ala Ser 
                405                 410                 415     


Ser Ile Trp Trp Val Ile Leu Ser Leu Thr Trp Phe Leu Ala Ala Gly 
            420                 425                 430         


Met Lys Trp Gly His Glu Ala Ile Glu Ala Asn Ser Gln Tyr Phe His 
        435                 440                 445             


Leu Ala Ala Trp Ala Val Pro Ala Ile Lys Thr Ile Thr Ile Leu Ala 
    450                 455                 460                 


Leu Gly Gln Val Asp Gly Asp Val Leu Ser Gly Val Cys Phe Val Gly 
465                 470                 475                 480 


Leu Asn Asn Val Asp Ala Leu Arg Gly Phe Val Leu Ala Pro Leu Phe 
                485                 490                 495     


Val Tyr Leu Phe Ile Gly Thr Ser Phe Leu Leu Ala Gly Phe Val Ser 
            500                 505                 510         


Leu Phe Arg Ile Arg Thr Ile Met Lys His Asp Gly Thr Lys Thr Glu 
        515                 520                 525             


Lys Leu Glu Lys Leu Met Val Arg Ile Gly Val Phe Ser Val Leu Tyr 
    530                 535                 540                 


Thr Val Pro Ala Thr Ile Val Ile Ala Cys Tyr Phe Tyr Glu Gln Ala 
545                 550                 555                 560 


Phe Arg Asp Gln Trp Glu Arg Ser Trp Val Ala Gln Ser Cys Lys Ser 
                565                 570                 575     


Tyr Ala Ile Pro Cys Pro His Leu Gln Ala Gly Gly Gly Ala Pro Pro 
            580                 585                 590         


His Pro Pro Met Ser Pro Asp Phe Thr Val Phe Met Ile Lys Tyr Leu 
        595                 600                 605             


Met Thr Leu Ile Val Gly Ile Thr Ser Gly Phe Trp Ile Trp Ser Gly 
    610                 615                 620                 


Lys Thr Leu Asn Ser Trp Arg Lys Phe Tyr Thr Arg Leu Thr Asn Ser 
625                 630                 635                 640 


Lys Gln Gly Glu Thr Thr Val 
                645         


<210>  25
<211>  5408
<212>  DNA
<213>  Homo sapiens

<400>  25
gttggctgga gagtttgtga aaagttgtga gccgagcagg aggaagtagg gagagaggag       60

ttgggctgtg ccggaggccg aggaccgaga gggctcaggt gacccctgga aagcctgggt      120

ggctggaaag gagcctagcg cctgcatgaa aggaagaacc tgctgggaag tacctgagct      180

cgagctgtgg gttccgccgc ccttcccctg cgtggtggct tggtggccgc gtctgcgcct      240

cagccctgag aatccggatg gcggtgaggt ggacttgggc aggcaagagc tgcctgctgc      300

tggcgttttt aacagtggcc tatatcttcg tggagctctt ggtctctact tttcatgcct      360

ccgcaggagc cggccgtgcc agggagctgg ggtcaagaag gctctcagac ctccagaaaa      420

atacggagga tttgtctcga ccgctttata agaagccccc tgcagattcc cgtgcacttg      480

gggagtgggg gaaagccagc aaactccagc tcaacgagga tgaactgaag cagcaagaag      540

aactcattga gagatacgcc atcaatattt acctcagtga caggatttcc ctgcatcgac      600

acatagagga taaaagaatg tatgagtgta agtcccagaa gttcaactat aggacacttc      660

ctaccacctc tgttatcatt gctttctata acgaagcctg gtcgactttg ctccgtacca      720

ttcacagtgt tttagaaact tctcctgcag ttcttttgaa agagatcatc ttggtggatg      780

acttgagtga cagagtttat ttgaagacac aacttgaaac ttacatcagc aatcttgata      840

gagtacgctt gattaggacc aataagcgag aggggctggt tagggcccgt ctgattgggg      900

ccactttcgc cactggggac gtcctcactt tcctggattg tcactgtgag tgtaattccg      960

gttggctgga accgcttttg gaaaggattg ggagagatga aacagcagtt gtgtgtcctg     1020

ttatagacac aattgattgg aatacttttg aattctatat gcagataggg gagcccatga     1080

ttggtgggtt tgactggcgt ttaacatttc agtggcattc tgtccccaaa caggaaaggg     1140

acaggcggat atcaagaatt gaccccatca gatcacctac catggctgga ggactgtttg     1200

ctgtcagcaa gaaatatttt cagtaccttg gaacgtatga cacaggaatg gaagtgtggg     1260

gaggtgaaaa ccttgagctg tcttttaggg tgtggcagtg tggtggcaaa ttggagatcc     1320

acccgtgttc ccacgtgggc catgtgttcc ccaagcgggc accatatgct cgccccaatt     1380

tcctacagaa tactgctcgg gcagcagaag tttggatgga tgaatacaaa gagcacttct     1440

acaatagaaa ccctccagca agaaaagaag cttatggtga tatttctgaa agaaaattac     1500

tacgagagcg gttgagatgc aagagctttg actggtattt gaaaaacgtt tttcctaatt     1560

tacatgttcc agaggataga ccaggctggc atggggctat tcgcagtaga gggatctcgt     1620

ctgaatgttt agattataat tctcctgaca acaaccccac aggtgctaac ctttcactgt     1680

ttggatgcca tggtcaagga ggcaatcaat tctttgaata tacttcaaac aaagaaataa     1740

ggtttaattc tgtgacagag ttatgtgcag aggtacctga gcaaaaaaat tatgtgggaa     1800

tgcaaaattg tcccaaagat gggttccctg taccagcaaa cattatttgg cattttaaag     1860

aagatggaac tatttttcac ccacactcag gactgtgtct tagtgcttat cggacaccgg     1920

agggccgacc tgatgtacaa atgagaactt gtgatgctct agataaaaat caaatttgga     1980

gttttgagaa atagagcaca acagcacttt cgtcatgagc tgacagtagt gtcaagaaag     2040

tcaaagagcc ttaagagcct cagtgaagat tgtattttat tttatcaaaa gccacctagc     2100

agtcatctgt ggagcactgg aaagctgggg ttcattttgg tatatcacac tgaaactggg     2160

tacccagagt gctgctgttt aatatttcac aatgccttac ttattggttg ttttatataa     2220

gagttttgtc aatatggtct cttcttaaaa gaagttgact atgaattgaa acacacaaaa     2280

catttaagtg ccagacttaa tattaaagaa tgtaaaggtc caagtaaaat gaggtatgat     2340

ttatgttgat gtgtaagttc accgcacatc ccacttttta acaaaactca tgaatgtgca     2400

gtttgagcca ttgctatttt gattacatag aatttgtatt tcttttttag ccagcacatt     2460

aaattttaga ttttattttt taatctaatt tttttctaat caaaaagaaa attgagctta     2520

aggcaaaagg cctggtttta gagatatgtg taattggaag agggcatttg tttgagtgtg     2580

agtttggagg cctttttaac atgcagacat acccatattt aaatgaaatg gggagatatt     2640

tacattccgt actttgtaaa cttgagctat tggacttcac tgatgtatat attaatacct     2700

cagattcctc tgattttgta agctgtcttc tctgtgaacg tgtttgtgtg tgtagggcat     2760

tttctgattg cacttcctta agttatgaat gtactagaaa gggactcatc cagaatacta     2820

tgcctccctt tgttaatgct taatcattta aagtaaacac aattgaagcc tctctgaagt     2880

taaacccaac tatgtttatt aaaatgtgtg aaactgaaag tgggctaggt tctaccaagg     2940

ctgtggaact ctcctacgag ttctgctgat caggaaattt aagaatttat cttaaaaatg     3000

caaggaaaaa agactgcctt ggcaattgtg aatggtgctt tcaatctcct agcaccgagc     3060

ctggcactta ggcagctttc agtaagtggg tgaatgaatg actgaatgaa tgaatgaatg     3120

gctcagctga ggaatgtaac tttggtcaag ttattatgat gtgtttgggc ttagttttct     3180

cattggtaaa atgtgggtgc tggattggat cttaaagatc ccttccagct ctgaaatgct     3240

gattgtacag tatattcttc ccagattgac tcactgtgca atctttacaa tactttttat     3300

cttttcactt ttgacatagg taatgttgtt gagcagttga gcaatgttca gtccagttgt     3360

gaagctggag aagagaaatg ggttttaaaa attaagtgag gggaggccgg gtgcggtggc     3420

tcacgcatgt aatcccagca ctttgggagg ccaaggcagg tggatcacga ggtcaggaga     3480

tccagaccat cctggctaac atggtgaaac ctcgtctcta ctaaaaatac aaaaaattag     3540

ccagctgtgg tggcgggcgc ctgtagtccc agctactcag gaggctgagg caggagaatg     3600

gcgtgaacct gtgaggcaga gcttacagtg agccgagatc gtgccactgc actccagcct     3660

gggcgacaga gcaagactct gtctcaaaaa aaaaaaataa taataaaata agtgagctga     3720

actcacctga agtggtttac ttctgtgggt taagaagttc tagtcagtgt tcatagtcgt     3780

ttcgttttga taattgttga accaattttg tttttaaaac ctttagactc tgaaagtaat     3840

attttgacta agaatgtaaa tatttccaaa ctaaattact cgggaagtaa acgctttttt     3900

taaaagtatt tttactggtt ttataccaat attatatgca gaaatcacag gatgaattta     3960

gaattaaatc tcaattagtt cactttggcc tagatttatg aaaaatgcat gcctcgtaaa     4020

gagtccactg tattcacgag taaagttgct tttagtgttc acttgatgac ttggagagta     4080

ggaattttgc aaaatctgaa tttaaggaaa ttctttagga taaccatttc aaaaaataaa     4140

attgctatgc aatcttgaat attttctctt ttgcctcgta aaatgaaaat gcattcacag     4200

tttctgtaaa ttatttagca gccttaaagt ttatcaaaaa attgtccaga ttccacgtgc     4260

agcatgcttg gccctgcatt taatttaaga aggattaata ataatgctct gaatttttcg     4320

aaagggattc tcctaaaccc acccacttct cttgcccagg ctgcttttta aaaatatttt     4380

tttatttttt acttattttt aaattttctc tttttattta tttttggttt tcttgttagc     4440

cacctgttat atgggagaac gaaaattgtt atattttgaa agtacttatt acattatttt     4500

tattttagta tcttgatgct cctgtcaaaa gggaaatgag gcttttaaaa ataaagtacc     4560

ttaattcttt attgactttt tgccctaaat tgctaggtgt gacccagcaa tcttttagga     4620

agagatttta cagtggtgct ttatttatat caataatcca gtatagttag gctgttcatt     4680

cctcataata gagtacataa cagaaaagtg ggactttcac attttcatat ttaggcacgt     4740

tccaatttaa ttccaaaaat actctgtaat tctacatcta aaaaaaccga ttccctaatt     4800

cgaatttatt ggtaccaaag ctctctttgg ctatagacaa ttaagagttg accttttaag     4860

ttaatgtata tgcttaaaaa cagttttagg aaaatatttg gtagacaaag agtttcaact     4920

ttaaatgttc actatgtcat ttagtgtcca actttacgga taggttgact atctaaatag     4980

gcatttttag tcattaaaaa aaatctagtc accaggagga tccctataac tcaaaataac     5040

ttgtttgtaa aagaaaattt gtttacttac ccattagtaa gttcctgcat attcattata     5100

agatggcaaa tcaaactttt ctaggatgaa gacagcttat ttttaagttg tatagtctta     5160

gttggtttag ggtctcaatt ttaattaata aaatacttgg tttttatttg cttgtccttt     5220

tgaattcctg ttttaataat tttaaaatga gcacaaagaa cgttgaagtt cagattaatc     5280

tcttctgaat gatgtttttt tcctctgtga tgagttgttt ctgacttttt tccttttgta     5340

tttgtaatgt tgattaagat gtaaaataaa aagtgtgcct gattattttt gcaaaaaaaa     5400

aaaaaaaa                                                              5408


<210>  26
<211>  578
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ala Val Arg Trp Thr Trp Ala Gly Lys Ser Cys Leu Leu Leu Ala 
1               5                   10                  15      


Phe Leu Thr Val Ala Tyr Ile Phe Val Glu Leu Leu Val Ser Thr Phe 
            20                  25                  30          


His Ala Ser Ala Gly Ala Gly Arg Ala Arg Glu Leu Gly Ser Arg Arg 
        35                  40                  45              


Leu Ser Asp Leu Gln Lys Asn Thr Glu Asp Leu Ser Arg Pro Leu Tyr 
    50                  55                  60                  


Lys Lys Pro Pro Ala Asp Ser Arg Ala Leu Gly Glu Trp Gly Lys Ala 
65                  70                  75                  80  


Ser Lys Leu Gln Leu Asn Glu Asp Glu Leu Lys Gln Gln Glu Glu Leu 
                85                  90                  95      


Ile Glu Arg Tyr Ala Ile Asn Ile Tyr Leu Ser Asp Arg Ile Ser Leu 
            100                 105                 110         


His Arg His Ile Glu Asp Lys Arg Met Tyr Glu Cys Lys Ser Gln Lys 
        115                 120                 125             


Phe Asn Tyr Arg Thr Leu Pro Thr Thr Ser Val Ile Ile Ala Phe Tyr 
    130                 135                 140                 


Asn Glu Ala Trp Ser Thr Leu Leu Arg Thr Ile His Ser Val Leu Glu 
145                 150                 155                 160 


Thr Ser Pro Ala Val Leu Leu Lys Glu Ile Ile Leu Val Asp Asp Leu 
                165                 170                 175     


Ser Asp Arg Val Tyr Leu Lys Thr Gln Leu Glu Thr Tyr Ile Ser Asn 
            180                 185                 190         


Leu Asp Arg Val Arg Leu Ile Arg Thr Asn Lys Arg Glu Gly Leu Val 
        195                 200                 205             


Arg Ala Arg Leu Ile Gly Ala Thr Phe Ala Thr Gly Asp Val Leu Thr 
    210                 215                 220                 


Phe Leu Asp Cys His Cys Glu Cys Asn Ser Gly Trp Leu Glu Pro Leu 
225                 230                 235                 240 


Leu Glu Arg Ile Gly Arg Asp Glu Thr Ala Val Val Cys Pro Val Ile 
                245                 250                 255     


Asp Thr Ile Asp Trp Asn Thr Phe Glu Phe Tyr Met Gln Ile Gly Glu 
            260                 265                 270         


Pro Met Ile Gly Gly Phe Asp Trp Arg Leu Thr Phe Gln Trp His Ser 
        275                 280                 285             


Val Pro Lys Gln Glu Arg Asp Arg Arg Ile Ser Arg Ile Asp Pro Ile 
    290                 295                 300                 


Arg Ser Pro Thr Met Ala Gly Gly Leu Phe Ala Val Ser Lys Lys Tyr 
305                 310                 315                 320 


Phe Gln Tyr Leu Gly Thr Tyr Asp Thr Gly Met Glu Val Trp Gly Gly 
                325                 330                 335     


Glu Asn Leu Glu Leu Ser Phe Arg Val Trp Gln Cys Gly Gly Lys Leu 
            340                 345                 350         


Glu Ile His Pro Cys Ser His Val Gly His Val Phe Pro Lys Arg Ala 
        355                 360                 365             


Pro Tyr Ala Arg Pro Asn Phe Leu Gln Asn Thr Ala Arg Ala Ala Glu 
    370                 375                 380                 


Val Trp Met Asp Glu Tyr Lys Glu His Phe Tyr Asn Arg Asn Pro Pro 
385                 390                 395                 400 


Ala Arg Lys Glu Ala Tyr Gly Asp Ile Ser Glu Arg Lys Leu Leu Arg 
                405                 410                 415     


Glu Arg Leu Arg Cys Lys Ser Phe Asp Trp Tyr Leu Lys Asn Val Phe 
            420                 425                 430         


Pro Asn Leu His Val Pro Glu Asp Arg Pro Gly Trp His Gly Ala Ile 
        435                 440                 445             


Arg Ser Arg Gly Ile Ser Ser Glu Cys Leu Asp Tyr Asn Ser Pro Asp 
    450                 455                 460                 


Asn Asn Pro Thr Gly Ala Asn Leu Ser Leu Phe Gly Cys His Gly Gln 
465                 470                 475                 480 


Gly Gly Asn Gln Phe Phe Glu Tyr Thr Ser Asn Lys Glu Ile Arg Phe 
                485                 490                 495     


Asn Ser Val Thr Glu Leu Cys Ala Glu Val Pro Glu Gln Lys Asn Tyr 
            500                 505                 510         


Val Gly Met Gln Asn Cys Pro Lys Asp Gly Phe Pro Val Pro Ala Asn 
        515                 520                 525             


Ile Ile Trp His Phe Lys Glu Asp Gly Thr Ile Phe His Pro His Ser 
    530                 535                 540                 


Gly Leu Cys Leu Ser Ala Tyr Arg Thr Pro Glu Gly Arg Pro Asp Val 
545                 550                 555                 560 


Gln Met Arg Thr Cys Asp Ala Leu Asp Lys Asn Gln Ile Trp Ser Phe 
                565                 570                 575     


Glu Lys 
        


<210>  27
<211>  5966
<212>  DNA
<213>  Homo sapiens

<400>  27
gttggagcgg ggccggcgcc gcagccgctt ctgctggctg agctgctgcc gccgccgggc       60

ggacgggcgg acgcgcggag ctgggggcgg cgcggcgggg ccggcggggc gcggcggggc      120

tgaccggccc cgatgaggcg gaaggagaag cggctcctgc aggcggtggc gctggtgctg      180

gcggccctgg tcctcctgcc caacgtgggg ctttgggcgc tgtaccgcga gcggcagccc      240

gacggcaccc ctgggggatc gggggcggcg gtggcgccgg cggcgggaca gggctcacac      300

agtcgacaaa agaaaacgtt tttcttggga gatgggcaga agctgaagga ctggcatgac      360

aaggaggcca tccggaggga cgctcagcgc gtaggaaatg gagaacaagg aagaccttac      420

cccatgaccg atgctgagag agtggatcag gcataccgag aaaatggatt taacatctac      480

gtcagtgata aaatctcctt gaatcgctct ctcccagata tccggcaccc aaactgcaac      540

agcaagcgct acctggagac acttcccaac acaagcatca tcatcccctt ccacaacgag      600

ggctggtcct ccctcctccg caccgtccac agtgtgctca atcgctcgcc tccagagctg      660

gtcgccgaga ttgtactggt cgacgacttc agtgatcgag agcacctgaa gaagcctctt      720

gaagactaca tggccctttt ccccagtgtg aggattcttc gaaccaagaa acgggaaggg      780

ctgataagga cccgaatgct gggggcctca gtggcaactg gggatgtcat cacattcttg      840

gattcacact gtgaagccaa tgtcaactgg cttcccccct tgcttgaccg cattgctcgg      900

aaccgcaaga ccattgtgtg cccgatgatt gatgtaattg accatgacga ctttcggtac      960

gagacacagg caggggatgc catgcgggga gcctttgact gggagatgta ctacaagcgg     1020

atcccgatcc ctccagaact gcagaaagct gaccccagcg acccatttga gtctcccgtg     1080

atggccggtg gactgttcgc cgtggatcgg aagtggttct gggaactcgg cgggtatgac     1140

ccaggcttgg agatctgggg aggggagcag tatgaaatct ccttcaaggt gtggatgtgt     1200

gggggccgca tggaggacat cccctgctcc agggtgggcc atatctacag gaagtatgtg     1260

ccctacaagg tcccggccgg agtcagcctg gcccggaacc ttaagcgggt ggccgaagtg     1320

tggatggatg agtacgcaga gtacatttac cagcgccggc ctgaataccg ccacctctcc     1380

gctggggatg tcgcagtcca gaaaaagctc cgcagctccc ttaactgcaa gagtttcaag     1440

tggtttatga cgaagatagc ctgggacctg cccaaattct acccacccgt ggagcccccg     1500

gctgcagctt ggggggagat ccgaaatgtg ggcacagggc tgtgtgcaga cacaaagcac     1560

ggggccttgg gctccccact aaggctagag ggctgcgtcc gaggccgtgg ggaggctgcc     1620

tggaacaaca tgcaggtatt caccttcacc tggagagagg acatccggcc tggagacccc     1680

cagcacacca agaagttctg ctttgatgcc atttcccaca ccagccctgt cacgctgtac     1740

gactgccaca gcatgaaggg caaccagctg tggaaatacc gcaaagacaa gaccctgtac     1800

caccctgtca gtggcagctg catggactgc agtgaaagtg accataggat cttcatgaac     1860

acctgcaacc catcctctct cacccagcag tggctgtttg aacacaccaa ctcaacagtc     1920

ttggaaaaat tcaataggaa ctgagccctc atgtcccctt ggcaggcccc ccagggtctg     1980

gcactcactg cagacttcct ctttcaaggg aggcagggcc cctgtgggca ctaggtgtaa     2040

aaggtgctgg ccaaatggtt cagggtgaag agggctcttg attcaggggc tggggtctgc     2100

ctggtccttg agcccctgag ttgtgggggt agggtgaaga gcatatccca caagaggccc     2160

cacagggagc agagactgct ttaatccctg ctgacatcac ggaaaagcaa cagagccttt     2220

tcaactttgt cactatgtcc ccttgaacat tatgtgggag aacaccaagg tagcctaggc     2280

cacccaaaag tgagtcctgc gaggttgccc agccctcaga tggctctcct acatgatggt     2340

gctttagaaa caaaggtaaa atttgcctgt ttggggcagc ttttagtatc gatgccactc     2400

atctgcagca gaagagaaag aagtcctctt ggggcttttt agtttctgcc gtcctggggg     2460

gaacattgca gttactgcac agcttctgtt ctctgtcaca accccaggtg atttggtccg     2520

gtcaaaggcc atacttgggg ccctaagagt gttcagtatt gaatgctgat cagctgccag     2580

gtgaggagtc agaagaggga gcccccctag acatttcttt gcagctatgg acatgcggga     2640

tatctccccc tgctctctgg gtatttgaaa tgtcaatttt agcactctcc aggcacaagg     2700

acagcccagc accagcttta cagggcagtg tttcagatgg ccctgagccc acggaaaagg     2760

ccaggtagac ctccaaacta gaaatgctgg ctgatttgcc ctgatccatg cttccatttc     2820

cctgtctctc ttccccaggc aattactggc ctcaaaagag gaacagaggt gctgcgaggt     2880

gctcacctca cagagtctgg aggcctccag gatcaactgt gggcaaagtg cctgcctctg     2940

acctcatcat ggttctagtt ctcatacaga actccagaat ttttaaagaa ctctataatt     3000

ggattgcaaa ctaggatgct acataggatt ctggtattcc acatccaata tggatttcta     3060

gaatgctgtg attaaaggag ccagccaggt gtaatacagt caaggcagcc cccagcctag     3120

agacaatctg tgaaatccaa agttggtggt gttgggaaag cagggggaca tgtgtccctc     3180

agctcagcag aggctgtggt acaacatggt ccttggtgaa gacctgcacc cctggaacct     3240

cccaccatca tcacaactgt agtctcattt gcagtggaga aaagaacccg acgtcccaca     3300

gccagatata cacccagctc catgccagcc cttcatgttt accttttgct ttgttaatta     3360

catgtcagac tcctagaggg cctccagact aataggaagc atttctgtaa ccaacctgcc     3420

acccactgat tcagaaatgg aaatcacatt ccacaatcta tggcttccac cagctagccc     3480

aggaaatact tgaaatcagc attccaatta gtgttgagtc tcttgattgt gtcatttacc     3540

aattaaataa ctgagaccta agtctgggaa cagagccacg aatctgcctt tgagatgctg     3600

gcagatctca aggccatcaa ttattggggg agggagggac aaacactccc aatcatccac     3660

cagtcagact gaatgtgtag ctggcgagga attacttcca cttctggccc agcacaagcc     3720

ctgctttggc cacctgtctg caagagaggc ggcccctgtg cttgcaacgc ttacgtgttg     3780

atcccagtgt ccttttccaa atgagtgctg tagctttaga agtggccctc tatagaaaga     3840

agtcaaaaga tgaggcccct tctagaatct aggataacaa gagtgttgac agtttgagga     3900

gtcgaattga gattcatcat caaagagcaa tgcagcgtcg ttaaaataaa aactgtgcct     3960

tttaaaaaga aaaatgcaaa tatagagcaa atccctaaac ttgaaccatt tcctagtgcc     4020

ttgctagaca aacataaagg ggcagggttg tggggagggg aacgtttttg gtggtgtgtg     4080

cagttcctac tggatgagtg tgtgtttctt aatgtctcat ttcaagcagg agatgttggg     4140

tctggagcaa gatctgagac tgagatgtcc cccaagggtg acaggtcaga tttatttcag     4200

tcagtgcaag tcacactcca aactaaaggc tgggcagtgc gtttagtctg tggcctagaa     4260

gacctcatca gcccccgaga ggaggccttg cattacctca ctgggacctg tttgggggcc     4320

atccctgcgg tccaccctct gaacccccag catgtttgtc ctgtttctca ccattgggtt     4380

aaggggtgcc gagcactagc tagacttcca catagtccca ccccaagtgg gcggcagtgt     4440

tcctggcatg accaggattc ctgtgaaagc aggagcagca gcaagccgtc ccgggcctgc     4500

ctttcccatc ctttggttct cctttccagt ctgggttcac accctgaaaa gggatgggtg     4560

tgtcctctga gcactctggc atttgtcatt gctgagccca tatcagtagg tcctgggact     4620

tgacaaagta tgtgggaggg gaaggaagga cagaacttga ctggctccat ttcatggacc     4680

aactgatcaa ttgccagtac taagccactc attgttatgg cttccttttt gaaaaccacc     4740

tgtctcaagg attcaggttt ctgctcacat ccccagctga tgctcaataa aactcagcca     4800

ggagcatatg gagatgctga cagccaggta atgggtgaga ctgtggggtc ccttttcctc     4860

taaagccttt actctgagga taaggtcaca aagtagggtg tgacttgaaa gtatcgtgac     4920

catgtggccc accagcagcc tttccaaagg ggaactccag agacatttca taatgcaaac     4980

agcactgttg ctttaagaac aaggcctttg gaggtggcta aacttgcacg cacgtgtgtg     5040

aaaagccatc ccatcttctg cctccagttg gagctttcag ctgttaaaac agtcagaaac     5100

tattgattct tccctttagg aaaaaatgct caggcagaac ggggtacatc cacaggagga     5160

atcggacgag aggatgtgac attcggtcca ggagagaaag agcagtttct gttaaagatg     5220

taacaaatgg atttccaaag tctacatgac attcactttt caaacttccc accagttgaa     5280

tttctttttt tccttaagaa acaggtgatg tcttggaaaa cagctcctta tgtctctctg     5340

tgcatctcca ttttcctagt ctctggagtc tcaaaaagag tggcaaagca ctttacagta     5400

gtaactgagg aatcagagtc tctgcttcag cgatatctag tttgtacagt tgggtgatct     5460

tttgtaattc ctaggaggta atgcattttt aatgttttct gaagctttgt aagtgtgaga     5520

gagggacaag aagtgcagtt ctgttctgga attccttatt gctttcaacg gacactcttt     5580

gtgaaaaatc caagtaatat tttagttcaa acttgatctt gagccaaggc ccactgccac     5640

ctctgggatg ggagtcggac ctacatacca agtgacaagt tcaccttaac atctgcttcc     5700

agaatggctt tgattcagcc gtgccaggca acagaacagg gtcagactcc tgctctgtta     5760

ttggcttgaa gactaggatc ccaaaggggt tggaggcagg gaatatttga aaattcagac     5820

tggaattcca ggccaaaagc tcaagaccac cagcctctcc tcctgcctgg aaaaataagc     5880

ctttgtgaaa gactgattta ccatgtacaa ttgtgattgt gaacgttgtt gagtaaacct     5940

ccagactttc tctaaaaaaa aaaaaa                                          5966


<210>  28
<211>  603
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Arg Arg Lys Glu Lys Arg Leu Leu Gln Ala Val Ala Leu Val Leu 
1               5                   10                  15      


Ala Ala Leu Val Leu Leu Pro Asn Val Gly Leu Trp Ala Leu Tyr Arg 
            20                  25                  30          


Glu Arg Gln Pro Asp Gly Thr Pro Gly Gly Ser Gly Ala Ala Val Ala 
        35                  40                  45              


Pro Ala Ala Gly Gln Gly Ser His Ser Arg Gln Lys Lys Thr Phe Phe 
    50                  55                  60                  


Leu Gly Asp Gly Gln Lys Leu Lys Asp Trp His Asp Lys Glu Ala Ile 
65                  70                  75                  80  


Arg Arg Asp Ala Gln Arg Val Gly Asn Gly Glu Gln Gly Arg Pro Tyr 
                85                  90                  95      


Pro Met Thr Asp Ala Glu Arg Val Asp Gln Ala Tyr Arg Glu Asn Gly 
            100                 105                 110         


Phe Asn Ile Tyr Val Ser Asp Lys Ile Ser Leu Asn Arg Ser Leu Pro 
        115                 120                 125             


Asp Ile Arg His Pro Asn Cys Asn Ser Lys Arg Tyr Leu Glu Thr Leu 
    130                 135                 140                 


Pro Asn Thr Ser Ile Ile Ile Pro Phe His Asn Glu Gly Trp Ser Ser 
145                 150                 155                 160 


Leu Leu Arg Thr Val His Ser Val Leu Asn Arg Ser Pro Pro Glu Leu 
                165                 170                 175     


Val Ala Glu Ile Val Leu Val Asp Asp Phe Ser Asp Arg Glu His Leu 
            180                 185                 190         


Lys Lys Pro Leu Glu Asp Tyr Met Ala Leu Phe Pro Ser Val Arg Ile 
        195                 200                 205             


Leu Arg Thr Lys Lys Arg Glu Gly Leu Ile Arg Thr Arg Met Leu Gly 
    210                 215                 220                 


Ala Ser Val Ala Thr Gly Asp Val Ile Thr Phe Leu Asp Ser His Cys 
225                 230                 235                 240 


Glu Ala Asn Val Asn Trp Leu Pro Pro Leu Leu Asp Arg Ile Ala Arg 
                245                 250                 255     


Asn Arg Lys Thr Ile Val Cys Pro Met Ile Asp Val Ile Asp His Asp 
            260                 265                 270         


Asp Phe Arg Tyr Glu Thr Gln Ala Gly Asp Ala Met Arg Gly Ala Phe 
        275                 280                 285             


Asp Trp Glu Met Tyr Tyr Lys Arg Ile Pro Ile Pro Pro Glu Leu Gln 
    290                 295                 300                 


Lys Ala Asp Pro Ser Asp Pro Phe Glu Ser Pro Val Met Ala Gly Gly 
305                 310                 315                 320 


Leu Phe Ala Val Asp Arg Lys Trp Phe Trp Glu Leu Gly Gly Tyr Asp 
                325                 330                 335     


Pro Gly Leu Glu Ile Trp Gly Gly Glu Gln Tyr Glu Ile Ser Phe Lys 
            340                 345                 350         


Val Trp Met Cys Gly Gly Arg Met Glu Asp Ile Pro Cys Ser Arg Val 
        355                 360                 365             


Gly His Ile Tyr Arg Lys Tyr Val Pro Tyr Lys Val Pro Ala Gly Val 
    370                 375                 380                 


Ser Leu Ala Arg Asn Leu Lys Arg Val Ala Glu Val Trp Met Asp Glu 
385                 390                 395                 400 


Tyr Ala Glu Tyr Ile Tyr Gln Arg Arg Pro Glu Tyr Arg His Leu Ser 
                405                 410                 415     


Ala Gly Asp Val Ala Val Gln Lys Lys Leu Arg Ser Ser Leu Asn Cys 
            420                 425                 430         


Lys Ser Phe Lys Trp Phe Met Thr Lys Ile Ala Trp Asp Leu Pro Lys 
        435                 440                 445             


Phe Tyr Pro Pro Val Glu Pro Pro Ala Ala Ala Trp Gly Glu Ile Arg 
    450                 455                 460                 


Asn Val Gly Thr Gly Leu Cys Ala Asp Thr Lys His Gly Ala Leu Gly 
465                 470                 475                 480 


Ser Pro Leu Arg Leu Glu Gly Cys Val Arg Gly Arg Gly Glu Ala Ala 
                485                 490                 495     


Trp Asn Asn Met Gln Val Phe Thr Phe Thr Trp Arg Glu Asp Ile Arg 
            500                 505                 510         


Pro Gly Asp Pro Gln His Thr Lys Lys Phe Cys Phe Asp Ala Ile Ser 
        515                 520                 525             


His Thr Ser Pro Val Thr Leu Tyr Asp Cys His Ser Met Lys Gly Asn 
    530                 535                 540                 


Gln Leu Trp Lys Tyr Arg Lys Asp Lys Thr Leu Tyr His Pro Val Ser 
545                 550                 555                 560 


Gly Ser Cys Met Asp Cys Ser Glu Ser Asp His Arg Ile Phe Met Asn 
                565                 570                 575     


Thr Cys Asn Pro Ser Ser Leu Thr Gln Gln Trp Leu Phe Glu His Thr 
            580                 585                 590         


Asn Ser Thr Val Leu Glu Lys Phe Asn Arg Asn 
        595                 600             


<210>  29
<211>  2838
<212>  DNA
<213>  Homo sapiens

<400>  29
gggtgggcgg gcggctgctc cggtccaggg gtggaggtcg gggccctgac ccgacgcagc       60

caggcggaag cgcggctgcc attggaggct gcttttacct gcgcggggcc cggggcgcaa      120

agtccgaggc gccgggggga ggaggcggcg gacggcagcg caggtgggcc cgcgctctcg      180

gccctgcaag atgcccctga agctgcgggg gaagaagaag gccaagtcca aggagaccgc      240

cgggctggtg gagggcgagc cgacgggcgc gggcggcggg agcctctcag cgtcccgggc      300

tcccgcacgc aggctggtct tccacgcgca gctggcgcac ggtagtgcca cgggccgagt      360

ggagggcttc tccagcatcc aggagctcta cgcccagatc gcgggcgcgt ttgaaatctc      420

gccgtcggag atcttatatt gcactttaaa cacacctaaa attgacatgg aaagactctt      480

aggaggacaa ctaggactag aagatttcat atttgcccat gtgaaaggaa tcgaaaaaga      540

agtgaatgtg tataaatctg aggattcact tggtctcacc attacagata atggtgttgg      600

ctatgctttt ataaagagaa ttaaagatgg tggtgttatt gactcagtta aaacaatctg      660

tgttggggat catattgaat ccataaatgg agaaaatatt gttgggtggc gtcactatga      720

tgttgctaag aagttaaagg aattaaaaaa ggaggaactc tttactatga agttaataga      780

acctaagaag gcatttgaaa tagagctgag gtcaaaggct ggaaagtcat caggagaaaa      840

aattggttgt ggaagggcaa cacttcgcct gagatcaaaa ggtcctgcca ccgtggaaga      900

aatgccttct gaaaccaaag caaaggcaat tgaaaagatt gatgatgttc ttgagttgta      960

catgggaatt cgagatattg atttagccac cacaatgttt gaagctggaa aggacaaagt     1020

aaatccagat gaatttgctg tggcacttga cgaaactctt ggagactttg cgttcccaga     1080

cgaatttgtc tttgatgttt ggggagtcat tggtgatgcc aaacgaagag gattatgatg     1140

tgtacactcc atctctgaag aaacaaccca tcgttctttt ttttctcttt tttaaaaagt     1200

cctataagat ctgtttttgg acacctttac taactctggt ttaatttcat gtgtatggaa     1260

tatattcttt gaaatataat tttggtaatt ttgatttctg ggcacttttt aacattgctg     1320

atgtagtatg cttaagagaa atgacctaaa taaggatcaa ttgtaatatt cattcaaaag     1380

gtttttaaaa gtaagtttta aggagtattt ctcgacagat gattttcttc tccattaata     1440

cccatgcttt gtttttcaca tataaataga tgatttcaat agctttgtag ttttttttca     1500

aaatcttaat gtaaactagg attggagtat gatttacctc atagtatctt cactgtgtta     1560

tcctagtttg aacaggatat gttcaggaaa tgaaaggtga attatgcccc ttattggtct     1620

agaagcattg gttttttttt gatcctctga gtaagggaag gaagattcct gtggcatgtt     1680

gatttctatg gccaactttc tctctttgta aaacaaagat tgattgattt tcttgtatgc     1740

ttctttatac atgctcttaa aacttgtggt tgaaatctgt gctgtgtgtg tgtgtctctg     1800

catgtgtaaa agaagggtaa aaaagagatg ggtagggtag aactacttgc atttgatttt     1860

tttttcagtc cttaaaacat tatttctttt tttcactcat agccactttt atgttacctt     1920

ttataagcac tccagggaag attttatatt tttttgtaga gtttttggaa agatatttac     1980

tcaaaataac tatgctttag aacttttttt tttttttttt ttttggttaa acagcagcac     2040

tttttagttc cctaaacttt agaagaaatg ctatcagaaa tagatttcct tccagtggaa     2100

agaaaggagg aagggagaat tgagaaaata tattagtcta ttattttaga gttctaatac     2160

actctaaatt atagagaaaa ttgagagtaa atgactgtct tatcactctt atttgacatt     2220

tcgtaggtgt aagagaaatg gaaatgaatg gtttcaacaa agatcattta atacagcaga     2280

gcatggcatg accaagcatc tttgtaaagt gttagatgga aaatgctgtg tgctgccatg     2340

gtaatcagaa ataataacct gttagggatg tattctagga aatcagaagt agttctcttt     2400

tcttgctgga ttattgctta gataactctt gttttctggt aaaactttag ttgtattgcc     2460

atccactcct ttttcaaatg agtttaatgc cataaagctg atattctttg tccgattaat     2520

ttgaaatctg cacagaagct gttttagtca ttaatgtgta acaaaagtag cttatagaat     2580

atggactgcc ttattgctgt tgcttatcat ttgaaaataa aatccagctc aggttgtaac     2640

ttgttggtac ttgtttagtg agttcgtttt ggaggttctg aaatacctat taattcttaa     2700

tattacctct cttggaaaga cacaaaaaaa gagctgttat ttttaggcat aagatgactt     2760

aggaggccca tagaaacgtt ctcgtttaaa caacaacaac aaaataaatt tatcagcact     2820

agaaaaaaaa aaaaaaaa                                                   2838


<210>  30
<211>  315
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Pro Leu Lys Leu Arg Gly Lys Lys Lys Ala Lys Ser Lys Glu Thr 
1               5                   10                  15      


Ala Gly Leu Val Glu Gly Glu Pro Thr Gly Ala Gly Gly Gly Ser Leu 
            20                  25                  30          


Ser Ala Ser Arg Ala Pro Ala Arg Arg Leu Val Phe His Ala Gln Leu 
        35                  40                  45              


Ala His Gly Ser Ala Thr Gly Arg Val Glu Gly Phe Ser Ser Ile Gln 
    50                  55                  60                  


Glu Leu Tyr Ala Gln Ile Ala Gly Ala Phe Glu Ile Ser Pro Ser Glu 
65                  70                  75                  80  


Ile Leu Tyr Cys Thr Leu Asn Thr Pro Lys Ile Asp Met Glu Arg Leu 
                85                  90                  95      


Leu Gly Gly Gln Leu Gly Leu Glu Asp Phe Ile Phe Ala His Val Lys 
            100                 105                 110         


Gly Ile Glu Lys Glu Val Asn Val Tyr Lys Ser Glu Asp Ser Leu Gly 
        115                 120                 125             


Leu Thr Ile Thr Asp Asn Gly Val Gly Tyr Ala Phe Ile Lys Arg Ile 
    130                 135                 140                 


Lys Asp Gly Gly Val Ile Asp Ser Val Lys Thr Ile Cys Val Gly Asp 
145                 150                 155                 160 


His Ile Glu Ser Ile Asn Gly Glu Asn Ile Val Gly Trp Arg His Tyr 
                165                 170                 175     


Asp Val Ala Lys Lys Leu Lys Glu Leu Lys Lys Glu Glu Leu Phe Thr 
            180                 185                 190         


Met Lys Leu Ile Glu Pro Lys Lys Ala Phe Glu Ile Glu Leu Arg Ser 
        195                 200                 205             


Lys Ala Gly Lys Ser Ser Gly Glu Lys Ile Gly Cys Gly Arg Ala Thr 
    210                 215                 220                 


Leu Arg Leu Arg Ser Lys Gly Pro Ala Thr Val Glu Glu Met Pro Ser 
225                 230                 235                 240 


Glu Thr Lys Ala Lys Ala Ile Glu Lys Ile Asp Asp Val Leu Glu Leu 
                245                 250                 255     


Tyr Met Gly Ile Arg Asp Ile Asp Leu Ala Thr Thr Met Phe Glu Ala 
            260                 265                 270         


Gly Lys Asp Lys Val Asn Pro Asp Glu Phe Ala Val Ala Leu Asp Glu 
        275                 280                 285             


Thr Leu Gly Asp Phe Ala Phe Pro Asp Glu Phe Val Phe Asp Val Trp 
    290                 295                 300                 


Gly Val Ile Gly Asp Ala Lys Arg Arg Gly Leu 
305                 310                 315 


<210>  31
<211>  2240
<212>  DNA
<213>  Homo sapiens

<400>  31
gtccttcggt gtctgggtgt ggtgagtaga ggtgtgtgtc acaaagtaca gaccattgtg       60

tgtgacaaag cccatcgtgt gtctgtgtgt gtctttatcc acgtggatgg acgtctcttt      120

cttgctctgc cccaagacac accctagccc ctccttattc tcaaaagggg gagctgggga      180

gcctccccct accctggggc ctcccctgcc cctccccgcc ctgcctggcc gtcaccactc      240

cccagagggc acagggctct gctgtgcctc agagcaaaag tcccagagcc agcagagcag      300

gctgacgacc tgcaagccac agtggctgcc ctgtgcgtgc tgcgaggtgg gggaccctgg      360

gcaggaagct ggctgagccc caagaccccg ggggccatgg gcggggatct ggtgcttggc      420

ctgggggcct tgagacgccg aaagcgcttg ctggagcagg agaagtctct ggccggctgg      480

gcactggtgc tggcaggaac tggcattgga ctcatggtgc tgcatgcaga gatgctgtgg      540

ttcggggggt gctcgtgggc gctctacctg ttcctggtta aatgcacgat cagcatttcc      600

accttcttac tcctctgcct catcgtggcc tttcatgcca aagaggtcca gctgttcatg      660

accgacaacg ggctgcggga ctggcgcgtg gcgctgaccg ggcggcaggc ggcgcagatc      720

gtgctggagc tggtggtgtg tgggctgcac ccggcgcccg tgcggggccc gccgtgcgtg      780

caggatttag gggcgccgct gacctccccg cagccctggc cgggattcct gggccaaggg      840

gaagcgctgc tgtccctggc catgctgctg cgtctctacc tggtgccccg cgccgtgctc      900

ctgcgcagcg gcgtcctgct caacgcttcc taccgcagca tcggcgctct caatcaagtc      960

cgcttccgcc actggttcgt ggccaagctt tacatgaaca cgcaccctgg ccgcctgctg     1020

ctcggcctca cgcttggcct ctggctgacc accgcctggg tgctgtccgt ggccgagagg     1080

caggctgtta atgccactgg gcacctttca gacacacttt ggctgatccc catcacattc     1140

ctgaccatcg gctatggtga cgtggtgccg ggcaccatgt ggggcaagat cgtctgcctg     1200

tgcactggag tcatgggtgt ctgctgcaca gccctgctgg tggccgtggt ggcccggaag     1260

ctggagttta acaaggcaga gaagcacgtg cacaacttca tgatggatat ccagtatacc     1320

aaagagatga aggagtccgc tgcccgagtg ctacaagaag cctggatgtt ctacaaacat     1380

actcgcagga aggagtctca tgctgcccgc aggcatcagc gcaagctgct ggccgccatc     1440

aacgcgttcc gccaggtgcg gctgaaacac cggaagctcc gggaacaagt gaactccatg     1500

gtggacatct ccaagatgca catgatcctg tatgacctgc agcagaatct gagcagctca     1560

caccgggccc tggagaaaca gattgacacg ctggcgggga agctggatgc cctgactgag     1620

ctgcttagca ctgccctggg gccgaggcag cttccagaac ccagccagca gtccaagtag     1680

ctggacccac gaggaggaac caggctactt tccccagtac tgaggtggtg gacatcgtct     1740

ctgccactcc tgacccagcc ctgaacaaag cacctcaagt gcaaggacca aagggggccc     1800

tggcttggag tgggttggct tgctgatggc tgctggaggg gacgctggct aaagtgggta     1860

ggccttggcc cacctgaggc cccaggtggg aacatggtca cccccactct gcataccctc     1920

atcaaaaaca ctctcactat gctgctatgg acgacctcca gctctcagtt acaagtgcag     1980

gcgactggag gcaggactcc tgggtccctg ggaaagaggg tactaggggc ccggatccag     2040

gattctggga ggcttcagtt accgctggcc gagctgaaga actgggtatg aggctggggc     2100

ggggctggag gtggcgcccc ctggtgggac aacaaagagg acaccatttt tccagagctg     2160

cagagagcac ctggtgggga ggaagaagtg taactcacca gcctctgctc ttatctttgt     2220

aataaatgtt aaagccagaa                                                 2240


<210>  32
<211>  427
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Gly Gly Asp Leu Val Leu Gly Leu Gly Ala Leu Arg Arg Arg Lys 
1               5                   10                  15      


Arg Leu Leu Glu Gln Glu Lys Ser Leu Ala Gly Trp Ala Leu Val Leu 
            20                  25                  30          


Ala Gly Thr Gly Ile Gly Leu Met Val Leu His Ala Glu Met Leu Trp 
        35                  40                  45              


Phe Gly Gly Cys Ser Trp Ala Leu Tyr Leu Phe Leu Val Lys Cys Thr 
    50                  55                  60                  


Ile Ser Ile Ser Thr Phe Leu Leu Leu Cys Leu Ile Val Ala Phe His 
65                  70                  75                  80  


Ala Lys Glu Val Gln Leu Phe Met Thr Asp Asn Gly Leu Arg Asp Trp 
                85                  90                  95      


Arg Val Ala Leu Thr Gly Arg Gln Ala Ala Gln Ile Val Leu Glu Leu 
            100                 105                 110         


Val Val Cys Gly Leu His Pro Ala Pro Val Arg Gly Pro Pro Cys Val 
        115                 120                 125             


Gln Asp Leu Gly Ala Pro Leu Thr Ser Pro Gln Pro Trp Pro Gly Phe 
    130                 135                 140                 


Leu Gly Gln Gly Glu Ala Leu Leu Ser Leu Ala Met Leu Leu Arg Leu 
145                 150                 155                 160 


Tyr Leu Val Pro Arg Ala Val Leu Leu Arg Ser Gly Val Leu Leu Asn 
                165                 170                 175     


Ala Ser Tyr Arg Ser Ile Gly Ala Leu Asn Gln Val Arg Phe Arg His 
            180                 185                 190         


Trp Phe Val Ala Lys Leu Tyr Met Asn Thr His Pro Gly Arg Leu Leu 
        195                 200                 205             


Leu Gly Leu Thr Leu Gly Leu Trp Leu Thr Thr Ala Trp Val Leu Ser 
    210                 215                 220                 


Val Ala Glu Arg Gln Ala Val Asn Ala Thr Gly His Leu Ser Asp Thr 
225                 230                 235                 240 


Leu Trp Leu Ile Pro Ile Thr Phe Leu Thr Ile Gly Tyr Gly Asp Val 
                245                 250                 255     


Val Pro Gly Thr Met Trp Gly Lys Ile Val Cys Leu Cys Thr Gly Val 
            260                 265                 270         


Met Gly Val Cys Cys Thr Ala Leu Leu Val Ala Val Val Ala Arg Lys 
        275                 280                 285             


Leu Glu Phe Asn Lys Ala Glu Lys His Val His Asn Phe Met Met Asp 
    290                 295                 300                 


Ile Gln Tyr Thr Lys Glu Met Lys Glu Ser Ala Ala Arg Val Leu Gln 
305                 310                 315                 320 


Glu Ala Trp Met Phe Tyr Lys His Thr Arg Arg Lys Glu Ser His Ala 
                325                 330                 335     


Ala Arg Arg His Gln Arg Lys Leu Leu Ala Ala Ile Asn Ala Phe Arg 
            340                 345                 350         


Gln Val Arg Leu Lys His Arg Lys Leu Arg Glu Gln Val Asn Ser Met 
        355                 360                 365             


Val Asp Ile Ser Lys Met His Met Ile Leu Tyr Asp Leu Gln Gln Asn 
    370                 375                 380                 


Leu Ser Ser Ser His Arg Ala Leu Glu Lys Gln Ile Asp Thr Leu Ala 
385                 390                 395                 400 


Gly Lys Leu Asp Ala Leu Thr Glu Leu Leu Ser Thr Ala Leu Gly Pro 
                405                 410                 415     


Arg Gln Leu Pro Glu Pro Ser Gln Gln Ser Lys 
            420                 425         


<210>  33
<211>  2721
<212>  DNA
<213>  Homo sapiens

<400>  33
gcgcacttcc gggtgttgtc tggccgccgt agcgcgtctt gggtctcccg gctgccgctg       60

ctgccgccgc cgcctcgggt cgtggagcca ggagcgacgt caccgccatg gcaggcatca      120

aagctttgat tagtttgtcc tttggaggag caatcggact gatgtttttg atgcttggat      180

gtgcccttcc aatatacaac aaatactggc ccctctttgt tctatttttt tacatccttt      240

cacctattcc atactgcata gcaagaagat tagtggatga tacagatgct atgagtaacg      300

cttgtaagga acttgccatc tttcttacaa cgggcattgt cgtgtcagct tttggactcc      360

ctattgtatt tgccagagca catctgattg agtggggagc ttgtgcactt gttctcacag      420

gaaacacagt catctttgca actatactag gctttttctt ggtctttgga agcaatgacg      480

acttcagctg gcagcagtgg tgaaaagaaa ttactgaact attgtcaaat ggacttcctg      540

tcatttgttg gccattcacg cacacaggag atggggcagt taatgctgaa tggtatagca      600

agcctcttgg gggtatttta ggtgctccct tctcactttt attgtaagca tactattttc      660

acagagactt gctgaaggat taaaaggatt ttctcttttg gaaaagcttg actgatttca      720

cacttatcta tagtatgctt tttgtggtgt cctgctgaat ttaaatattt atgtgttttt      780

cctgttaggt tgattttttt tggaatcaat atgcaatgtt aaacactttt ttaatgtaat      840

catttgcatt ggttaggaat tcagaattcc gccggctcta ttactggtca agtacatctt      900

ttctcttaaa attatttagc ctccattatt acaaaaaatt ataaaaataa gttttcagtc      960

agtcaggatg acatcactcc caatgttatg cagacataca gacggttggc atacgttata     1020

gactgtatac tcagtgcaaa tatagctgca tttatacctc agaggggcca agtgttaatg     1080

cccatgccct ccgttaaggg ttgttggttt tactggtaga cagatgtttt gtggattgaa     1140

aattatttta tggaattgct acagaggagt gcttttcttc tcaattgtta gaagaattta     1200

tgttaaactt taaggtaagg gtgtaaaaac atttttgaga taaggttttt atttatgttt     1260

attattgtta gagtgagttg caatgtggga agaaatgaca ttgaaattcc agtttttgaa     1320

tcctgtttct atttataagt gaaatttgtg atctcctatc aacctttcat gttttaccct     1380

gttaaaatgg acatacatgg aaccactact gatgagggac agttgtatgt ttgcatcata     1440

tatgccagaa aaccttcctc tgcttcctcc ttttgactta tttggtatgt tgtatatatt     1500

acataaaata acttttcaaa tatagtttaa taacacttag aagtgtttac ttacctggaa     1560

aataattgct atgccgtaca ttcagagtgc cccctcccct gcaaggcctt gccatgatta     1620

acaagtaact tgttagtctt acagataatt catgcattaa cagtttaaga tttagaccat     1680

ggtaatagta gttcttattc tctaaggtta tatcatatgt aatttaaaag tatttttaag     1740

acaagtttcc tgtatacctc tgaactgttt tgattttgag ttcatcatga tagatctgct     1800

gtttccttat aaaaggcatt tgttgtgtga gttaatgcaa agtagccaag tccagctata     1860

tagcagcttc agaaacatac ctgaccaaaa aattcccagt aaccaggcat gatcaattta     1920

tagtggtcgt ttacatctaa taattatcag gacttttttc aggagtgggt tataaaaaca     1980

ttcaagttgg tctgacagta ttttgttaag gatatttgtt tgtatgttta ttcagtatac     2040

ttacataaaa attatttcgc catcagccaa aactcagtaa tcatgacagc tgtctgttgt     2100

tttatgaagt ttatttctca agaaaatggg aataaatttg ggatttgttc agctttttta     2160

ctaaagatgc ctaaagccac aggttttatt gcctaactta agccatgact tttagatatg     2220

agatgacggg aagcaggacg aaatatcggc gtgtggctgg agccttccca ctggaggctg     2280

aaagtggctt gtggtattat aatgttcaga tttcaagagg aaggtgcagg tacacatgag     2340

ttagagagct ggtgagacag ttgggaactc tttgtgcttg tgatctactg gacttttttt     2400

tgcaggaagt gcattctctg gtccttccct attttctgtt ctggatgtca gtgcagtgca     2460

ctgctactgt tttatccact tggccacaga ctttttctaa cagctgcgta ttatttctat     2520

atactaattg cattggcagc attgtgtctt tgaccttgta tactagcttg acatagtgct     2580

gtctctgatt tctaggctag ttacttgaga tatgaatttt ccatagaata tgcactgata     2640

caacattacc attcttctat ggaaagaaaa cttttgatga tgaaacaata aagattttaa     2700

atatctattt taaaaaaaaa a                                               2721


<210>  34
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Ala Gly Ile Lys Ala Leu Ile Ser Leu Ser Phe Gly Gly Ala Ile 
1               5                   10                  15      


Gly Leu Met Phe Leu Met Leu Gly Cys Ala Leu Pro Ile Tyr Asn Lys 
            20                  25                  30          


Tyr Trp Pro Leu Phe Val Leu Phe Phe Tyr Ile Leu Ser Pro Ile Pro 
        35                  40                  45              


Tyr Cys Ile Ala Arg Arg Leu Val Asp Asp Thr Asp Ala Met Ser Asn 
    50                  55                  60                  


Ala Cys Lys Glu Leu Ala Ile Phe Leu Thr Thr Gly Ile Val Val Ser 
65                  70                  75                  80  


Ala Phe Gly Leu Pro Ile Val Phe Ala Arg Ala His Leu Ile Glu Trp 
                85                  90                  95      


Gly Ala Cys Ala Leu Val Leu Thr Gly Asn Thr Val Ile Phe Ala Thr 
            100                 105                 110         


Ile Leu Gly Phe Phe Leu Val Phe Gly Ser Asn Asp Asp Phe Ser Trp 
        115                 120                 125             


Gln Gln Trp 
    130     


<210>  35
<211>  2611
<212>  DNA
<213>  Homo sapiens

<400>  35
gcgcgtccgg gctcccgggg ctggtaatat agcggctcgc cgaggcgctg gtgcacgggg       60

gcagcgcgca gcaggccggc gggcaggcgg gcgggctggc tggcaggcag gactgggatc      120

gaggcccaga aaacggagca gcgggcacca gggaggcctg gaacggggcg agcgccatga      180

gcaacaaatg cgacgtggtc gtggtggggg gcggcatctc aggtatggca gcagccaaac      240

ttctgcatga ctctggactg aatgtggttg ttctggaagc ccgggaccgt gtgggaggca      300

ggacttacac tcttaggaac caaaaggtta aatatgtgga ccttggagga tcctatgttg      360

gaccaaccca gaatcgtatc ttgagattag ccaaggagct aggattggag acctacaaag      420

tgaatgaggt tgagcgtctg atccaccatg taaagggcaa atcatacccc ttcagggggc      480

cattcccacc tgtatggaat ccaattacct acttagatca taacaacttt tggaggacaa      540

tggatgacat ggggcgagag attccgagtg atgccccatg gaaggctccc cttgcagaag      600

agtgggacaa catgacaatg aaggagctac tggacaagct ctgctggact gaatctgcaa      660

agcagcttgc cactctcttt gtgaacctgt gtgtcactgc agagacccat gaggtctctg      720

ctctctggtt cctgtggtat gtgaagcagt gtggaggcac aacaagaatc atctcgacaa      780

caaatggagg acaggagagg aaatttgtgg gcggatctgg tcaagtgagt gagcggataa      840

tggacctcct tggagaccga gtgaagctgg agaggcctgt gatctacatt gaccagacaa      900

gagaaaatgt ccttgtggag accctaaacc atgagatgta tgaggctaaa tatgtgatta      960

gtgctattcc tcctactctg ggcatgaaga ttcacttcaa tccccctctg ccaatgatga     1020

gaaaccagat gatcactcgt gtgcctttgg gttcagtcat caagtgtata gtttattata     1080

aagagccttt ctggaggaaa aaggattact gtggaaccat gattattgat ggagaagaag     1140

ctccagttgc ctacacgttg gatgatacca aacctgaagg caactatgct gccataatgg     1200

gatttatcct ggcccacaaa gccagaaaac tggcacgtct taccaaagag gaaaggttga     1260

agaaactttg tgaactctat gccaaggttc tgggttccct agaagctctg gagccagtgc     1320

attatgaaga aaagaactgg tgtgaggagc agtactctgg gggctgctac acaacttatt     1380

tcccccctgg gatcctgact caatatggaa gggttctacg ccagccagtg gacaggattt     1440

actttgcagg caccgagact gccacacact ggagcggcta catggagggg gctgtagagg     1500

ccggggagag agcagcccga gagatcctgc atgccatggg gaagattcca gaggatgaaa     1560

tctggcagtc agaaccagag tctgtggatg tccctgcaca gcccatcacc accacctttt     1620

tggagagaca tttgccctcc gtgccaggcc tgctcaggct gattggattg accaccatct     1680

tttcagcaac ggctcttggc ttcctggccc acaaaagggg gctacttgtg agagtctaaa     1740

gagagagggt gtctgtaatc acactctctt cttactgtat ttgggatatg agtttgggga     1800

aagagttgca gtaaagttcc atgaagacaa atagtgtgga gtgaggcggg gagcatgaag     1860

ataaatccaa ctctgactgt aaaatacatg gtatctcttt ctccgttgtg gcccctgctt     1920

agtgtccctt acctggctta gcgttctgtt tcaccagttt ccaagtttat tgccctcaaa     1980

atctttagaa tagttaaatt ggcttgttta aggttcttgc tgccccacaa cacaccttgc     2040

ccatgcacaa ggaatgaatt ttttcctacc attatggctt tgtgcttgtt cttcctctta     2100

cctgtaatag cctcaccttc cctagttctt tgcattcgtc cttagaatac tgtattgtta     2160

cagctgaaag acagtaaaga ccatttagtc ctcaccttct gttttagagt tgagcaaact     2220

gaagcccaca gaggtggaac ttaattacct aagagccaca ataagccact ggtatctggg     2280

ggactagaac acaaatccaa cgcttttccc acctctttgg atgttttccc caattatcct     2340

ccttcactcc ctgtcatagt taccgatggt gtcccgttgt gtgggtttac tctgtgctaa     2400

gttgtcttac acttctcaaa tgctactcag tatatagcct taagtcttac tgttttgtgc     2460

ggtgtgtctc cagctgattt taactttttt gatggtagaa attttatctc ttcttccttt     2520

tgtatcctcc attgtatctt catacaaagg acagtacaca cttgggtaat taaaaataaa     2580

agttgattga ccataaaaaa aaaaaaaaaa a                                    2611


<210>  36
<211>  520
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Ser Asn Lys Cys Asp Val Val Val Val Gly Gly Gly Ile Ser Gly 
1               5                   10                  15      


Met Ala Ala Ala Lys Leu Leu His Asp Ser Gly Leu Asn Val Val Val 
            20                  25                  30          


Leu Glu Ala Arg Asp Arg Val Gly Gly Arg Thr Tyr Thr Leu Arg Asn 
        35                  40                  45              


Gln Lys Val Lys Tyr Val Asp Leu Gly Gly Ser Tyr Val Gly Pro Thr 
    50                  55                  60                  


Gln Asn Arg Ile Leu Arg Leu Ala Lys Glu Leu Gly Leu Glu Thr Tyr 
65                  70                  75                  80  


Lys Val Asn Glu Val Glu Arg Leu Ile His His Val Lys Gly Lys Ser 
                85                  90                  95      


Tyr Pro Phe Arg Gly Pro Phe Pro Pro Val Trp Asn Pro Ile Thr Tyr 
            100                 105                 110         


Leu Asp His Asn Asn Phe Trp Arg Thr Met Asp Asp Met Gly Arg Glu 
        115                 120                 125             


Ile Pro Ser Asp Ala Pro Trp Lys Ala Pro Leu Ala Glu Glu Trp Asp 
    130                 135                 140                 


Asn Met Thr Met Lys Glu Leu Leu Asp Lys Leu Cys Trp Thr Glu Ser 
145                 150                 155                 160 


Ala Lys Gln Leu Ala Thr Leu Phe Val Asn Leu Cys Val Thr Ala Glu 
                165                 170                 175     


Thr His Glu Val Ser Ala Leu Trp Phe Leu Trp Tyr Val Lys Gln Cys 
            180                 185                 190         


Gly Gly Thr Thr Arg Ile Ile Ser Thr Thr Asn Gly Gly Gln Glu Arg 
        195                 200                 205             


Lys Phe Val Gly Gly Ser Gly Gln Val Ser Glu Arg Ile Met Asp Leu 
    210                 215                 220                 


Leu Gly Asp Arg Val Lys Leu Glu Arg Pro Val Ile Tyr Ile Asp Gln 
225                 230                 235                 240 


Thr Arg Glu Asn Val Leu Val Glu Thr Leu Asn His Glu Met Tyr Glu 
                245                 250                 255     


Ala Lys Tyr Val Ile Ser Ala Ile Pro Pro Thr Leu Gly Met Lys Ile 
            260                 265                 270         


His Phe Asn Pro Pro Leu Pro Met Met Arg Asn Gln Met Ile Thr Arg 
        275                 280                 285             


Val Pro Leu Gly Ser Val Ile Lys Cys Ile Val Tyr Tyr Lys Glu Pro 
    290                 295                 300                 


Phe Trp Arg Lys Lys Asp Tyr Cys Gly Thr Met Ile Ile Asp Gly Glu 
305                 310                 315                 320 


Glu Ala Pro Val Ala Tyr Thr Leu Asp Asp Thr Lys Pro Glu Gly Asn 
                325                 330                 335     


Tyr Ala Ala Ile Met Gly Phe Ile Leu Ala His Lys Ala Arg Lys Leu 
            340                 345                 350         


Ala Arg Leu Thr Lys Glu Glu Arg Leu Lys Lys Leu Cys Glu Leu Tyr 
        355                 360                 365             


Ala Lys Val Leu Gly Ser Leu Glu Ala Leu Glu Pro Val His Tyr Glu 
    370                 375                 380                 


Glu Lys Asn Trp Cys Glu Glu Gln Tyr Ser Gly Gly Cys Tyr Thr Thr 
385                 390                 395                 400 


Tyr Phe Pro Pro Gly Ile Leu Thr Gln Tyr Gly Arg Val Leu Arg Gln 
                405                 410                 415     


Pro Val Asp Arg Ile Tyr Phe Ala Gly Thr Glu Thr Ala Thr His Trp 
            420                 425                 430         


Ser Gly Tyr Met Glu Gly Ala Val Glu Ala Gly Glu Arg Ala Ala Arg 
        435                 440                 445             


Glu Ile Leu His Ala Met Gly Lys Ile Pro Glu Asp Glu Ile Trp Gln 
    450                 455                 460                 


Ser Glu Pro Glu Ser Val Asp Val Pro Ala Gln Pro Ile Thr Thr Thr 
465                 470                 475                 480 


Phe Leu Glu Arg His Leu Pro Ser Val Pro Gly Leu Leu Arg Leu Ile 
                485                 490                 495     


Gly Leu Thr Thr Ile Phe Ser Ala Thr Ala Leu Gly Phe Leu Ala His 
            500                 505                 510         


Lys Arg Gly Leu Leu Val Arg Val 
        515                 520 


<210>  37
<211>  6762
<212>  DNA
<213>  Homo sapiens

<400>  37
ggacggccga gcggcagggc gctcgcgcgc gcccactagt ggccggagga gaaggctccc       60

gcggaggccg cgctgcccgc cccctcccct ggggaggctc gcgttcccgc tgctcgcgcc      120

tgcgccgccc gccggcctca ggaacgcgcc ctcttcgccg gcgcgcgccc tcgcagtcac      180

cgccacccac cagctccggc accaacagca gcgccgctgc caccgcccac cttctgccgc      240

cgccaccaca gccaccttct cctcctccgc tgtcctctcc cgtcctcgcc tctgtcgact      300

atcaggtgaa ctttgaacca ggatggctga gccccgccag gagttcgaag tgatggaaga      360

tcacgctggg acgtacgggt tgggggacag gaaagatcag gggggctaca ccatgcacca      420

agaccaagag ggtgacacgg acgctggcct gaaagaatct cccctgcaga cccccactga      480

ggacggatct gaggaaccgg gctctgaaac ctctgatgct aagagcactc caacagcgga      540

agatgtgaca gcacccttag tggatgaggg agctcccggc aagcaggctg ccgcgcagcc      600

ccacacggag atcccagaag gaaccacagc tgaagaagca ggcattggag acacccccag      660

cctggaagac gaagctgctg gtcacgtgac ccaagagcct gaaagtggta aggtggtcca      720

ggaaggcttc ctccgagagc caggcccccc aggtctgagc caccagctca tgtccggcat      780

gcctggggct cccctcctgc ctgagggccc cagagaggcc acacgccaac cttcggggac      840

aggacctgag gacacagagg gcggccgcca cgcccctgag ctgctcaagc accagcttct      900

aggagacctg caccaggagg ggccgccgct gaagggggca gggggcaaag agaggccggg      960

gagcaaggag gaggtggatg aagaccgcga cgtcgatgag tcctcccccc aagactcccc     1020

tccctccaag gcctccccag cccaagatgg gcggcctccc cagacagccg ccagagaagc     1080

caccagcatc ccaggcttcc cagcggaggg tgccatcccc ctccctgtgg atttcctctc     1140

caaagtttcc acagagatcc cagcctcaga gcccgacggg cccagtgtag ggcgggccaa     1200

agggcaggat gcccccctgg agttcacgtt tcacgtggaa atcacaccca acgtgcagaa     1260

ggagcaggcg cactcggagg agcatttggg aagggctgca tttccagggg cccctggaga     1320

ggggccagag gcccggggcc cctctttggg agaggacaca aaagaggctg accttccaga     1380

gccctctgaa aagcagcctg ctgctgctcc gcgggggaag cccgtcagcc gggtccctca     1440

actcaaagct cgcatggtca gtaaaagcaa agacgggact ggaagcgatg acaaaaaagc     1500

caagacatcc acacgttcct ctgctaaaac cttgaaaaat aggccttgcc ttagccccaa     1560

acaccccact cctggtagct cagaccctct gatccaaccc tccagccctg ctgtgtgccc     1620

agagccacct tcctctccta aatacgtctc ttctgtcact tcccgaactg gcagttctgg     1680

agcaaaggag atgaaactca agggggctga tggtaaaacg aagatcgcca caccgcgggg     1740

agcagcccct ccaggccaga agggccaggc caacgccacc aggattccag caaaaacccc     1800

gcccgctcca aagacaccac ccagctctgg tgaacctcca aaatcagggg atcgcagcgg     1860

ctacagcagc cccggctccc caggcactcc cggcagccgc tcccgcaccc cgtcccttcc     1920

aaccccaccc acccgggagc ccaagaaggt ggcagtggtc cgtactccac ccaagtcgcc     1980

gtcttccgcc aagagccgcc tgcagacagc ccccgtgccc atgccagacc tgaagaatgt     2040

caagtccaag atcggctcca ctgagaacct gaagcaccag ccgggaggcg ggaaggtgca     2100

gataattaat aagaagctgg atcttagcaa cgtccagtcc aagtgtggct caaaggataa     2160

tatcaaacac gtcccgggag gcggcagtgt gcaaatagtc tacaaaccag ttgacctgag     2220

caaggtgacc tccaagtgtg gctcattagg caacatccat cataaaccag gaggtggcca     2280

ggtggaagta aaatctgaga agcttgactt caaggacaga gtccagtcga agattgggtc     2340

cctggacaat atcacccacg tccctggcgg aggaaataaa aagattgaaa cccacaagct     2400

gaccttccgc gagaacgcca aagccaagac agaccacggg gcggagatcg tgtacaagtc     2460

gccagtggtg tctggggaca cgtctccacg gcatctcagc aatgtctcct ccaccggcag     2520

catcgacatg gtagactcgc cccagctcgc cacgctagct gacgaggtgt ctgcctccct     2580

ggccaagcag ggtttgtgat caggcccctg gggcggtcaa taattgtgga gaggagagaa     2640

tgagagagtg tggaaaaaaa aagaataatg acccggcccc cgccctctgc ccccagctgc     2700

tcctcgcagt tcggttaatt ggttaatcac ttaacctgct tttgtcactc ggctttggct     2760

cgggacttca aaatcagtga tgggagtaag agcaaatttc atctttccaa attgatgggt     2820

gggctagtaa taaaatattt aaaaaaaaac attcaaaaac atggccacat ccaacatttc     2880

ctcaggcaat tccttttgat tcttttttct tccccctcca tgtagaagag ggagaaggag     2940

aggctctgaa agctgcttct gggggatttc aagggactgg gggtgccaac cacctctggc     3000

cctgttgtgg gggtgtcaca gaggcagtgg cagcaacaaa ggatttgaaa cttggtgtgt     3060

tcgtggagcc acaggcagac gatgtcaacc ttgtgtgagt gtgacggggg ttggggtggg     3120

gcgggaggcc acgggggagg ccgaggcagg ggctgggcag aggggagagg aagcacaaga     3180

agtgggagtg ggagaggaag ccacgtgctg gagagtagac atccccctcc ttgccgctgg     3240

gagagccaag gcctatgcca cctgcagcgt ctgagcggcc gcctgtcctt ggtggccggg     3300

ggtgggggcc tgctgtgggt cagtgtgcca ccctctgcag ggcagcctgt gggagaaggg     3360

acagcgggta aaaagagaag gcaagctggc aggagggtgg cacttcgtgg atgacctcct     3420

tagaaaagac tgaccttgat gtcttgagag cgctggcctc ttcctccctc cctgcagggt     3480

agggggcctg agttgagggg cttccctctg ctccacagaa accctgtttt attgagttct     3540

gaaggttgga actgctgcca tgattttggc cactttgcag acctgggact ttagggctaa     3600

ccagttctct ttgtaaggac ttgtgcctct tgggagacgt ccacccgttt ccaagcctgg     3660

gccactggca tctctggagt gtgtgggggt ctgggaggca ggtcccgagc cccctgtcct     3720

tcccacggcc actgcagtca ccccgtctgc gccgctgtgc tgttgtctgc cgtgagagcc     3780

caatcactgc ctatacccct catcacacgt cacaatgtcc cgaattccca gcctcaccac     3840

cccttctcag taatgaccct ggttggttgc aggaggtacc tactccatac tgagggtgaa     3900

attaagggaa ggcaaagtcc aggcacaaga gtgggacccc agcctctcac tctcagttcc     3960

actcatccaa ctgggaccct caccacgaat ctcatgatct gattcggttc cctgtctcct     4020

cctcccgtca cagatgtgag ccagggcact gctcagctgt gaccctaggt gtttctgcct     4080

tgttgacatg gagagagccc tttcccctga gaaggcctgg ccccttcctg tgctgagccc     4140

acagcagcag gctgggtgtc ttggttgtca gtggtggcac caggatggaa gggcaaggca     4200

cccagggcag gcccacagtc ccgctgtccc ccacttgcac cctagcttgt agctgccaac     4260

ctcccagaca gcccagcccg ctgctcagct ccacatgcat agtatcagcc ctccacaccc     4320

gacaaagggg aacacacccc cttggaaatg gttcttttcc cccagtccca gctggaagcc     4380

atgctgtctg ttctgctgga gcagctgaac atatacatag atgttgccct gccctcccca     4440

tctgcaccct gttgagttgt agttggattt gtctgtttat gcttggattc accagagtga     4500

ctatgatagt gaaaagaaaa aaaaaaaaaa aaaaggacgc atgtatcttg aaatgcttgt     4560

aaagaggttt ctaacccacc ctcacgaggt gtctctcacc cccacactgg gactcgtgtg     4620

gcctgtgtgg tgccaccctg ctggggcctc ccaagttttg aaaggctttc ctcagcacct     4680

gggacccaac agagaccagc ttctagcagc taaggaggcc gttcagctgt gacgaaggcc     4740

tgaagcacag gattaggact gaagcgatga tgtccccttc cctacttccc cttggggctc     4800

cctgtgtcag ggcacagact aggtcttgtg gctggtctgg cttgcggcgc gaggatggtt     4860

ctctctggtc atagcccgaa gtctcatggc agtcccaaag gaggcttaca actcctgcat     4920

cacaagaaaa aggaagccac tgccagctgg ggggatctgc agctcccaga agctccgtga     4980

gcctcagcca cccctcagac tgggttcctc tccaagctcg ccctctggag gggcagcgca     5040

gcctcccacc aagggccctg cgaccacagc agggattggg atgaattgcc tgtcctggat     5100

ctgctctaga ggcccaagct gcctgcctga ggaaggatga cttgacaagt caggagacac     5160

tgttcccaaa gccttgacca gagcacctca gcccgctgac cttgcacaaa ctccatctgc     5220

tgccatgaga aaagggaagc cgcctttgca aaacattgct gcctaaagaa actcagcagc     5280

ctcaggccca attctgccac ttctggtttg ggtacagtta aaggcaaccc tgagggactt     5340

ggcagtagaa atccagggcc tcccctgggg ctggcagctt cgtgtgcagc tagagcttta     5400

cctgaaagga agtctctggg cccagaactc tccaccaaga gcctccctgc cgttcgctga     5460

gtcccagcaa ttctcctaag ttgaagggat ctgagaagga gaaggaaatg tggggtagat     5520

ttggtggtgg ttagagatat gcccccctca ttactgccaa cagtttcggc tgcatttctt     5580

cacgcacctc ggttcctctt cctgaagttc ttgtgccctg ctcttcagca ccatgggcct     5640

tcttatacgg aaggctctgg gatctccccc ttgtggggca ggctcttggg gccagcctaa     5700

gatcatggtt tagggtgatc agtgctggca gataaattga aaaggcacgc tggcttgtga     5760

tcttaaatga ggacaatccc cccagggctg ggcactcctc ccctcccctc acttctccca     5820

cctgcagagc cagtgtcctt gggtgggcta gataggatat actgtatgcc ggctccttca     5880

agctgctgac tcactttatc aatagttcca tttaaattga cttcagtggt gagactgtat     5940

cctgtttgct attgcttgtt gtgctatggg gggagggggg aggaatgtgt aagatagtta     6000

acatgggcaa agggagatct tggggtgcag cacttaaact gcctcgtaac ccttttcatg     6060

atttcaacca catttgctag agggagggag cagccacgga gttagaggcc cttggggttt     6120

ctcttttcca ctgacaggct ttcccaggca gctggctagt tcattccctc cccagccagg     6180

tgcaggcgta ggaatatgga catctggttg ctttggcctg ctgccctctt tcaggggtcc     6240

taagcccaca atcatgcctc cctaagacct tggcatcctt ccctctaagc cgttggcacc     6300

tctgtgccac ctctcacact ggctccagac acacagcctg tgcttttgga gctgagatca     6360

ctcgcttcac cctcctcatc tttgttctcc aagtaaagcc acgaggtcgg ggcgagggca     6420

gaggtgatca cctgcgtgtc ccatctacag acctgcagct tcataaaact tctgatttct     6480

cttcagcttt gaaaagggtt accctgggca ctggcctaga gcctcacctc ctaatagact     6540

tagccccatg agtttgccat gttgagcagg actatttctg gcacttgcaa gtcccatgat     6600

ttcttcggta attctgaggg tggggggagg gacatgaaat catcttagct tagctttctg     6660

tctgtgaatg tctatatagt gtattgtgtg ttttaacaaa tgatttacac tgactgttgc     6720

tgtaaaagtg aatttggaaa taaagttatt actctgatta aa                        6762


<210>  38
<211>  758
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    50                  55                  60                  


Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr Ala Pro Leu Val 
65                  70                  75                  80  


Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln Pro His Thr Glu 
                85                  90                  95      


Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro 
            100                 105                 110         


Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Glu Pro Glu Ser 
        115                 120                 125             


Gly Lys Val Val Gln Glu Gly Phe Leu Arg Glu Pro Gly Pro Pro Gly 
    130                 135                 140                 


Leu Ser His Gln Leu Met Ser Gly Met Pro Gly Ala Pro Leu Leu Pro 
145                 150                 155                 160 


Glu Gly Pro Arg Glu Ala Thr Arg Gln Pro Ser Gly Thr Gly Pro Glu 
                165                 170                 175     


Asp Thr Glu Gly Gly Arg His Ala Pro Glu Leu Leu Lys His Gln Leu 
            180                 185                 190         


Leu Gly Asp Leu His Gln Glu Gly Pro Pro Leu Lys Gly Ala Gly Gly 
        195                 200                 205             


Lys Glu Arg Pro Gly Ser Lys Glu Glu Val Asp Glu Asp Arg Asp Val 
    210                 215                 220                 


Asp Glu Ser Ser Pro Gln Asp Ser Pro Pro Ser Lys Ala Ser Pro Ala 
225                 230                 235                 240 


Gln Asp Gly Arg Pro Pro Gln Thr Ala Ala Arg Glu Ala Thr Ser Ile 
                245                 250                 255     


Pro Gly Phe Pro Ala Glu Gly Ala Ile Pro Leu Pro Val Asp Phe Leu 
            260                 265                 270         


Ser Lys Val Ser Thr Glu Ile Pro Ala Ser Glu Pro Asp Gly Pro Ser 
        275                 280                 285             


Val Gly Arg Ala Lys Gly Gln Asp Ala Pro Leu Glu Phe Thr Phe His 
    290                 295                 300                 


Val Glu Ile Thr Pro Asn Val Gln Lys Glu Gln Ala His Ser Glu Glu 
305                 310                 315                 320 


His Leu Gly Arg Ala Ala Phe Pro Gly Ala Pro Gly Glu Gly Pro Glu 
                325                 330                 335     


Ala Arg Gly Pro Ser Leu Gly Glu Asp Thr Lys Glu Ala Asp Leu Pro 
            340                 345                 350         


Glu Pro Ser Glu Lys Gln Pro Ala Ala Ala Pro Arg Gly Lys Pro Val 
        355                 360                 365             


Ser Arg Val Pro Gln Leu Lys Ala Arg Met Val Ser Lys Ser Lys Asp 
    370                 375                 380                 


Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys Thr Ser Thr Arg Ser Ser 
385                 390                 395                 400 


Ala Lys Thr Leu Lys Asn Arg Pro Cys Leu Ser Pro Lys His Pro Thr 
                405                 410                 415     


Pro Gly Ser Ser Asp Pro Leu Ile Gln Pro Ser Ser Pro Ala Val Cys 
            420                 425                 430         


Pro Glu Pro Pro Ser Ser Pro Lys Tyr Val Ser Ser Val Thr Ser Arg 
        435                 440                 445             


Thr Gly Ser Ser Gly Ala Lys Glu Met Lys Leu Lys Gly Ala Asp Gly 
    450                 455                 460                 


Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro Gly Gln Lys 
465                 470                 475                 480 


Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro Pro Ala Pro 
                485                 490                 495     


Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly Asp Arg Ser 
            500                 505                 510         


Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser Arg Ser Arg 
        515                 520                 525             


Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys Lys Val Ala 
    530                 535                 540                 


Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys Ser Arg Leu 
545                 550                 555                 560 


Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val Lys Ser Lys 
                565                 570                 575     


Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys Val 
            580                 585                 590         


Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln Ser Lys Cys 
        595                 600                 605             


Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly Ser Val Gln 
    610                 615                 620                 


Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys Cys Gly 
625                 630                 635                 640 


Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val Glu Val 
                645                 650                 655     


Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys Ile Gly 
            660                 665                 670         


Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys Lys Ile 
        675                 680                 685             


Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp 
    690                 695                 700                 


His Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser Gly Asp Thr 
705                 710                 715                 720 


Ser Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly Ser Ile Asp Met 
                725                 730                 735     


Val Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu Val Ser Ala Ser 
            740                 745                 750         


Leu Ala Lys Gln Gly Leu 
        755             


<210>  39
<211>  3039
<212>  DNA
<213>  Homo sapiens

<400>  39
ggtccctggg ctcccgctcg ccgccgctgc cgctcctcgt tctgctcctc actccccagc       60

ggctggaggc cggtaccggc gggcaggagg cgcccgagga tgtgctgctg gccgctgctc      120

ctgctgtggg ggctgctccc cgggacggcg gcggggggct cgggccgaac ctatccgcac      180

cggaccctcc tggactcgga gggcaagtac tggctgggct ggagccagcg gggcagccag      240

atcgccttcc gcctccaggt gcgcactgca ggctacgtgg gcttcggctt ctcgcccacc      300

ggggccatgg cgtccgccga catcgtcgtg ggcggggtgg cccacgggcg gccctacctc      360

caggattatt ttacaaatgc aaatagagag ttgaaaaaag atgctcagca agattaccat      420

ctagaatatg ccatggaaaa tagcacacac acaataattg aatttaccag agagctgcat      480

acatgtgaca taaatgacaa gagtataacg gatagcactg tgagagtgat ctgggcctac      540

caccatgaag atgcaggaga agctggtccc aagtaccatg actccaatag gggcaccaag      600

agtttgcggt tattgaatcc tgagaaaact agtgtgctat ctacagcctt accatacttt      660

gatctggtaa atcaggacgt ccccatccca aacaaagata caacatattg gtgccaaatg      720

tttaagattc ctgtgttcca agaaaagcat catgtaataa aggttgagcc agtgatacag      780

agaggccatg agagtctggt gcaccacatc ctgctctatc agtgcagcaa caactttaac      840

gacagcgttc tggagtccgg ccacgagtgc tatcacccca acatgcccga tgcattcctc      900

acctgtgaaa ctgtgatttt tgcctgggct attggtggag agggcttttc ttatccacct      960

catgttggat tatcccttgg cactccatta gatccgcatt atgtgctcct agaagtccat     1020

tatgataatc ccacttatga ggaaggctta atagataatt ctggactgag gttattttac     1080

acaatggata taaggaaata tgatgctggg gtgattgagg ctggcctctg ggtgagcctc     1140

ttccatacca tccctccagg gatgcctgag ttccagtctg agggtcactg cactttggag     1200

tgcctggaag aggctctgga agccgaaaag ccaagtggaa ttcatgtgtt tgctgttctt     1260

ctccatgctc acctggctgg cagaggcatc aggctgcgtc attttcgaaa agggaaggaa     1320

atgaaattac ttgcctatga tgatgatttt gacttcaatt tccaggagtt tcagtatcta     1380

aaggaagaac aaacaatctt accaggagat aacctaatta ctgagtgtcg ctacaacacg     1440

aaagatagag ctgagatgac ttggggagga ctaagcacca ggagtgaaat gtgtctctca     1500

taccttcttt attacccaag aattaatctt actcgatgtg caagtattcc agacattatg     1560

gaacaacttc agttcattgg ggttaaggag atctacagac cagtcacgac ctggcctttc     1620

attatcaaaa gtcccaagca atataaaaac ctttctttca tggatgctat gaataagttt     1680

aaatggacta aaaaggaagg tctctccttc aacaagctgg tcctcagcct gccagtgaat     1740

gtgagatgtt ccaagacaga caatgctgag tggtcgattc aaggaatgac agcattacct     1800

ccagatatag aaagacccta taaagcagaa cctttggtgt gtggcacgtc ttcttcctct     1860

tccctgcaca gagatttctc catcaacttg cttgtttgcc ttctgctact cagctgcacg     1920

ctgagcacca agagcttgtg atcaaaattc tgttggactt gacaatgttt tctatgatct     1980

gaacctgtca tttgaagtac aggttaaaga ctgtgtccac tttgggcatg aagagtgtgg     2040

agacttttct tccccatttt ccctccctcc tttttccttt ccatgttaca tgagagacat     2100

caatcaggtt ctcttctctt tcttagaaat atctgatgtt atatatacat ggtcaataaa     2160

ataaaactgg cctgacttaa gataaccatt ttaaaaaatt gggctgtcat gtgggaataa     2220

aagaattctt tctttcctac tacattctgt tttatttaaa tactcattgt tgctatttca     2280

ctttttgact tgacttttat atttctttaa aaaattcctt ccttttaaaa aatataaaag     2340

ggactactgt tcattccagt tttcttcttc tttgttgttc ttctagtgtg acttttcaag     2400

tgtaacagcc attcttcctg actttaatat tgtccagttc tggtcttttc tgtgaattac     2460

cactgggccc cttacctcaa tgctttttgt tgatgcccac tctggttccc ttgtttatct     2520

gagtctgttg gtaccccaaa tgaccccaca cccatcttaa agtacttttt ttcaccttcc     2580

ctgtttagta ctggccagat gagttttttc tagagctctg tcactatctg aaaagaaaga     2640

ggctatggga aacatagaaa tggtatgtat taataactga tcataggctg aggagaaaaa     2700

atgtagctgg ctgcaaaccc agtgctgtga ggtgacttat atgaggttcc agatcaaaga     2760

caggccgtgt gagccagtcc aggagggtgt aagttctgaa tggttccttg ctgactttgg     2820

gtgacacatg taccacatac tggctcagtt taagtcatgg ttctattgta gatttatttt     2880

tatattagtt aataaatgac tttaaattgt caccaattga aaatcttgtc actcttttgg     2940

ttttctttat atagctcagc caaatcttgt tttatgtcct gtcctcatct cttaagctaa     3000

atctgtttgg atcatattaa taaactaaat gaaattaca                            3039


<210>  40
<211>  613
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Cys Cys Trp Pro Leu Leu Leu Leu Trp Gly Leu Leu Pro Gly Thr 
1               5                   10                  15      


Ala Ala Gly Gly Ser Gly Arg Thr Tyr Pro His Arg Thr Leu Leu Asp 
            20                  25                  30          


Ser Glu Gly Lys Tyr Trp Leu Gly Trp Ser Gln Arg Gly Ser Gln Ile 
        35                  40                  45              


Ala Phe Arg Leu Gln Val Arg Thr Ala Gly Tyr Val Gly Phe Gly Phe 
    50                  55                  60                  


Ser Pro Thr Gly Ala Met Ala Ser Ala Asp Ile Val Val Gly Gly Val 
65                  70                  75                  80  


Ala His Gly Arg Pro Tyr Leu Gln Asp Tyr Phe Thr Asn Ala Asn Arg 
                85                  90                  95      


Glu Leu Lys Lys Asp Ala Gln Gln Asp Tyr His Leu Glu Tyr Ala Met 
            100                 105                 110         


Glu Asn Ser Thr His Thr Ile Ile Glu Phe Thr Arg Glu Leu His Thr 
        115                 120                 125             


Cys Asp Ile Asn Asp Lys Ser Ile Thr Asp Ser Thr Val Arg Val Ile 
    130                 135                 140                 


Trp Ala Tyr His His Glu Asp Ala Gly Glu Ala Gly Pro Lys Tyr His 
145                 150                 155                 160 


Asp Ser Asn Arg Gly Thr Lys Ser Leu Arg Leu Leu Asn Pro Glu Lys 
                165                 170                 175     


Thr Ser Val Leu Ser Thr Ala Leu Pro Tyr Phe Asp Leu Val Asn Gln 
            180                 185                 190         


Asp Val Pro Ile Pro Asn Lys Asp Thr Thr Tyr Trp Cys Gln Met Phe 
        195                 200                 205             


Lys Ile Pro Val Phe Gln Glu Lys His His Val Ile Lys Val Glu Pro 
    210                 215                 220                 


Val Ile Gln Arg Gly His Glu Ser Leu Val His His Ile Leu Leu Tyr 
225                 230                 235                 240 


Gln Cys Ser Asn Asn Phe Asn Asp Ser Val Leu Glu Ser Gly His Glu 
                245                 250                 255     


Cys Tyr His Pro Asn Met Pro Asp Ala Phe Leu Thr Cys Glu Thr Val 
            260                 265                 270         


Ile Phe Ala Trp Ala Ile Gly Gly Glu Gly Phe Ser Tyr Pro Pro His 
        275                 280                 285             


Val Gly Leu Ser Leu Gly Thr Pro Leu Asp Pro His Tyr Val Leu Leu 
    290                 295                 300                 


Glu Val His Tyr Asp Asn Pro Thr Tyr Glu Glu Gly Leu Ile Asp Asn 
305                 310                 315                 320 


Ser Gly Leu Arg Leu Phe Tyr Thr Met Asp Ile Arg Lys Tyr Asp Ala 
                325                 330                 335     


Gly Val Ile Glu Ala Gly Leu Trp Val Ser Leu Phe His Thr Ile Pro 
            340                 345                 350         


Pro Gly Met Pro Glu Phe Gln Ser Glu Gly His Cys Thr Leu Glu Cys 
        355                 360                 365             


Leu Glu Glu Ala Leu Glu Ala Glu Lys Pro Ser Gly Ile His Val Phe 
    370                 375                 380                 


Ala Val Leu Leu His Ala His Leu Ala Gly Arg Gly Ile Arg Leu Arg 
385                 390                 395                 400 


His Phe Arg Lys Gly Lys Glu Met Lys Leu Leu Ala Tyr Asp Asp Asp 
                405                 410                 415     


Phe Asp Phe Asn Phe Gln Glu Phe Gln Tyr Leu Lys Glu Glu Gln Thr 
            420                 425                 430         


Ile Leu Pro Gly Asp Asn Leu Ile Thr Glu Cys Arg Tyr Asn Thr Lys 
        435                 440                 445             


Asp Arg Ala Glu Met Thr Trp Gly Gly Leu Ser Thr Arg Ser Glu Met 
    450                 455                 460                 


Cys Leu Ser Tyr Leu Leu Tyr Tyr Pro Arg Ile Asn Leu Thr Arg Cys 
465                 470                 475                 480 


Ala Ser Ile Pro Asp Ile Met Glu Gln Leu Gln Phe Ile Gly Val Lys 
                485                 490                 495     


Glu Ile Tyr Arg Pro Val Thr Thr Trp Pro Phe Ile Ile Lys Ser Pro 
            500                 505                 510         


Lys Gln Tyr Lys Asn Leu Ser Phe Met Asp Ala Met Asn Lys Phe Lys 
        515                 520                 525             


Trp Thr Lys Lys Glu Gly Leu Ser Phe Asn Lys Leu Val Leu Ser Leu 
    530                 535                 540                 


Pro Val Asn Val Arg Cys Ser Lys Thr Asp Asn Ala Glu Trp Ser Ile 
545                 550                 555                 560 


Gln Gly Met Thr Ala Leu Pro Pro Asp Ile Glu Arg Pro Tyr Lys Ala 
                565                 570                 575     


Glu Pro Leu Val Cys Gly Thr Ser Ser Ser Ser Ser Leu His Arg Asp 
            580                 585                 590         


Phe Ser Ile Asn Leu Leu Val Cys Leu Leu Leu Leu Ser Cys Thr Leu 
        595                 600                 605             


Ser Thr Lys Ser Leu 
    610             


<210>  41
<211>  5895
<212>  DNA
<213>  Homo sapiens

<400>  41
gcagttggtg aaactcctct gtctcccgct catcttttca ttgctcgttc ccctccttcc       60

cgcagacacc cggacctccc ctgggcgcca gctccgcggc tccaacgggt ccagaaacaa      120

gccggatttt ttttttttct tcctggaaat tggctttggt gtgtgttgcc ctacctccct      180

cctccccctc ccacccacag cccccccccg gccttttttt tttttttttt tttttttgag      240

acatggcccg ggcagtggct cctggaagag gaacaagtgt gggaaaaggg agaggaagcc      300

ggagctaaat gacaggatgc aggcgacttg agacacaaaa agagaagcgt tcctctcgga      360

tccaggcatt gcctcgctgc tttcttttct ccaagacggg ctgaggattg tacagctcta      420

ggcggagttg gggctcttcg gatcgcttag attctcctct ttgctgcatt tccccccacg      480

tcctcgttct cccgcgtctg cctgcggacc cggagaaggg agaatggaga gggggctgcc      540

gctcctctgc gccgtgctcg ccctcgtcct cgccccggcc ggcgcttttc gcaacgataa      600

atgtggcgat actataaaaa ttgaaagccc cgggtacctt acatctcctg gttatcctca      660

ttcttatcac ccaagtgaaa aatgcgaatg gctgattcag gctccggacc cataccagag      720

aattatgatc aacttcaacc ctcacttcga tttggaggac agagactgca agtatgacta      780

cgtggaagtc ttcgatggag aaaatgaaaa tggacatttt aggggaaagt tctgtggaaa      840

gatagcccct cctcctgttg tgtcttcagg gccatttctt tttatcaaat ttgtctctga      900

ctacgaaaca catggtgcag gattttccat acgttatgaa attttcaaga gaggtcctga      960

atgttcccag aactacacaa cacctagtgg agtgataaag tcccccggat tccctgaaaa     1020

atatcccaac agccttgaat gcacttatat tgtctttgcg ccaaagatgt cagagattat     1080

cctggaattt gaaagctttg acctggagcc tgactcaaat cctccagggg ggatgttctg     1140

tcgctacgac cggctagaaa tctgggatgg attccctgat gttggccctc acattgggcg     1200

ttactgtgga cagaaaacac caggtcgaat ccgatcctca tcgggcattc tctccatggt     1260

tttttacacc gacagcgcga tagcaaaaga aggtttctca gcaaactaca gtgtcttgca     1320

gagcagtgtc tcagaagatt tcaaatgtat ggaagctctg ggcatggaat caggagaaat     1380

tcattctgac cagatcacag cttcttccca gtatagcacc aactggtctg cagagcgctc     1440

ccgcctgaac taccctgaga atgggtggac tcccggagag gattcctacc gagagtggat     1500

acaggtagac ttgggccttc tgcgctttgt cacggctgtc gggacacagg gcgccatttc     1560

aaaagaaacc aagaagaaat attatgtcaa gacttacaag atcgacgtta gctccaacgg     1620

ggaagactgg atcaccataa aagaaggaaa caaacctgtt ctctttcagg gaaacaccaa     1680

ccccacagat gttgtggttg cagtattccc caaaccactg ataactcgat ttgtccgaat     1740

caagcctgca acttgggaaa ctggcatatc tatgagattt gaagtatacg gttgcaagat     1800

aacagattat ccttgctctg gaatgttggg tatggtgtct ggacttattt ctgactccca     1860

gatcacatca tccaaccaag gggacagaaa ctggatgcct gaaaacatcc gcctggtaac     1920

cagtcgctct ggctgggcac ttccacccgc acctcattcc tacatcaatg agtggctcca     1980

aatagacctg ggggaggaga agatcgtgag gggcatcatc attcagggtg ggaagcaccg     2040

agagaacaag gtgttcatga ggaagttcaa gatcgggtac agcaacaacg gctcggactg     2100

gaagatgatc atggatgaca gcaaacgcaa ggcgaagtct tttgagggca acaacaacta     2160

tgatacacct gagctgcgga cttttccagc tctctccacg cgattcatca ggatctaccc     2220

cgagagagcc actcatggcg gactggggct cagaatggag ctgctgggct gtgaagtgga     2280

agcccctaca gctggaccga ccactcccaa cgggaacttg gtggatgaat gtgatgacga     2340

ccaggccaac tgccacagtg gaacaggtga tgacttccag ctcacaggtg gcaccactgt     2400

gctggccaca gaaaagccca cggtcataga cagcaccata caatcagagt ttccaacata     2460

tggttttaac tgtgaatttg gctggggctc tcacaagacc ttctgccact gggaacatga     2520

caatcacgtg cagctcaagt ggagtgtgtt gaccagcaag acgggaccca ttcaggatca     2580

cacaggagat ggcaacttca tctattccca agctgacgaa aatcagaagg gcaaagtggc     2640

tcgcctggtg agccctgtgg tttattccca gaactctgcc cactgcatga ccttctggta     2700

tcacatgtct gggtcccacg tcggcacact cagggtcaaa ctgcgctacc agaagccaga     2760

ggagtacgat cagctggtct ggatggccat tggacaccaa ggtgaccact ggaaggaagg     2820

gcgtgtcttg ctccacaagt ctctgaaact ttatcaggtg attttcgagg gcgaaatcgg     2880

aaaaggaaac cttggtggga ttgctgtgga tgacattagt attaataacc acatttcaca     2940

agaagattgt gcaaaaccag cagacctgga taaaaagaac ccagaaatta aaattgatga     3000

aacagggagc acgccaggat acgaaggtga aggagaaggt gacaagaaca tctccaggaa     3060

gccaggcaat gtgttgaaga ccttagaccc catcctcatc accatcatag ccatgagtgc     3120

cctgggggtc ctcctggggg ctgtctgtgg ggtcgtgctg tactgtgcct gttggcataa     3180

tgggatgtca gaaagaaact tgtctgccct ggagaactat aactttgaac ttgtggatgg     3240

tgtgaagttg aaaaaagaca aactgaatac acagagtact tattcggagg catgaaggca     3300

gacagagatg aaaagacagt caaaggacgg aagtggaagg acgggagtga gctggggagc     3360

tgttgatctt tcactataca ggctgggaag tgtgttgatg accactgagc caggcttttc     3420

tcaggagctt caatgagtat ggccgacaga catggacaag gagctgtgtt caccatcgga     3480

ctcatgtgca gtcagctttt ttcctgttgg tttcatttga ataatcagat gctggtgttg     3540

agaccaagta tgattgacat aatcattcat ttcgacccct cctgcccctc tctctctctc     3600

tcctctcccc tttgtggatt ctttttggaa actgagcgaa atccaagatg ctggcaccaa     3660

gcgtattccg tgtggccctt tggatggaca tgctacctga aacccagtgc ccagaatata     3720

ctagaatcac cgcatttcag tggactcctg aagttgtact tgtgtataat tgcccgcgtc     3780

gtgcataggc aaagaaggat taggctgttt tctttttaaa gtactgtagc ctcagtactg     3840

gtgtagtgtg tcagctctgt ttacgaagca atactgtcca gttttcttgc tgtttttccg     3900

gtgttgtact aaacctcgtg cttgtgaact ccatacagaa aacggtgcca tccctgaaca     3960

cggctggcca ctgggtatac tgctgacaac cgcaacaaca aaaacacaaa tccttggcac     4020

tggctagtct atgtcctctc aagtgccttt ttgtttgtac tggttcattg tgttacatta     4080

acgacccact ctgcttcttg ctggtgaaag ccctgctctt taatcaaact ctggtggccc     4140

actgactaag aagaaagttt attttcgtgt gagatgccag cccctccggg caggcaaggg     4200

ctctgaagat ttggcaacgt ggcttaattg ttctgctttt tctgtagttc aatttcatgt     4260

ttcttgaccc ttttgtataa agctacaata ttctctctta ttgttctttc atatggaatg     4320

tattttcaaa tgtaaactct cttctctttc tctctcctat ctctctgtct tttttctctc     4380

ttagaattgg aggatttgcc attgtccagg aaagaaactt gcagctttaa cctgctggga     4440

atggcaaacg attttactag actttatgtt taaaaataaa taaataaggg aaattcctaa     4500

ctttgccctc caaagtctaa ctttggtttt cttgttaact ggttaaagtg acagtatctt     4560

ttttccttat ctattctatt caaaatgacc tttgatagaa atgttggcat ttagtagaaa     4620

tagtgataag ttgaggaaag aaataataca aattggcttt caagtgagac ccaaaggaag     4680

aactggataa aatcttccaa atccaaaagc atgagatttt tctatccaaa tatgcaaaaa     4740

tgacccaaga gaactttctt attttgctac tgagtcacac aagggaagtg gaaggaagaa     4800

cagttaattt aagaatgaaa ctataaatcc tgatgcctgg gggtcaagta ttttaagata     4860

agagggggaa aaacacataa agtcaaacaa atgttttaaa aattcataac agcaaccttg     4920

aaaaaataga cttaaatgaa tgcttctaga aacttccagc ggctcacaaa gaataagcct     4980

gccttagggc tggcaacatc taagcctcta acagcacagg gaagcaaata tcttaccagg     5040

cagcctatga attaacccaa agaagctttg gttggttttg gtggattttt atcatgccat     5100

gttggacatg agatttttta gatcttcctt cccacattgc tagacgtctc actcaaagac     5160

atttgttggg agtcacattt gcatcataga cgagacagtc cattcatctt agttaaattg     5220

gattgagaat gccttttgtt tccaggaaaa tattgatcac catgaaagaa gaatagtttt     5280

ttgtccccag agacattcat ttagttgata taatcctacc agaaggaaag cactaagaaa     5340

cactcgtttg ttgtttttaa aggcaacaga cttaaagttg tcctcagcca aggaaaaatg     5400

atactgcaac tttaaaattt aaagtatctt gcactgataa atatatttaa aaattatatg     5460

tttataaagt tattaatttg taaaggcagt gttacaaaat gttcagttta tattgtttta     5520

gattgttttg taatttttaa aggtgtaaaa taacatattt tttctttatg gaaatctata     5580

aaactttctg tagtaaaatg ttttcatttt actggtatat tattgcttca tgttttgtac     5640

catcataaga ttttgtgcag atttttttta cagaaattat tattttctat gacaatatga     5700

cacttgtaaa ttgttgtttc aaaatgaaca gcgaagcctt aactttaaat gacatttgta     5760

ttctcagaca ctgagtagca taaaaaccac atagaactga actgtaactt aaattccaaa     5820

ctatgactac tacattccaa agaaacagtt gaattaaaca ttttcataaa atatcccaca     5880

aaaaaaaaaa aaaaa                                                      5895


<210>  42
<211>  923
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Glu Arg Gly Leu Pro Leu Leu Cys Ala Val Leu Ala Leu Val Leu 
1               5                   10                  15      


Ala Pro Ala Gly Ala Phe Arg Asn Asp Lys Cys Gly Asp Thr Ile Lys 
            20                  25                  30          


Ile Glu Ser Pro Gly Tyr Leu Thr Ser Pro Gly Tyr Pro His Ser Tyr 
        35                  40                  45              


His Pro Ser Glu Lys Cys Glu Trp Leu Ile Gln Ala Pro Asp Pro Tyr 
    50                  55                  60                  


Gln Arg Ile Met Ile Asn Phe Asn Pro His Phe Asp Leu Glu Asp Arg 
65                  70                  75                  80  


Asp Cys Lys Tyr Asp Tyr Val Glu Val Phe Asp Gly Glu Asn Glu Asn 
                85                  90                  95      


Gly His Phe Arg Gly Lys Phe Cys Gly Lys Ile Ala Pro Pro Pro Val 
            100                 105                 110         


Val Ser Ser Gly Pro Phe Leu Phe Ile Lys Phe Val Ser Asp Tyr Glu 
        115                 120                 125             


Thr His Gly Ala Gly Phe Ser Ile Arg Tyr Glu Ile Phe Lys Arg Gly 
    130                 135                 140                 


Pro Glu Cys Ser Gln Asn Tyr Thr Thr Pro Ser Gly Val Ile Lys Ser 
145                 150                 155                 160 


Pro Gly Phe Pro Glu Lys Tyr Pro Asn Ser Leu Glu Cys Thr Tyr Ile 
                165                 170                 175     


Val Phe Ala Pro Lys Met Ser Glu Ile Ile Leu Glu Phe Glu Ser Phe 
            180                 185                 190         


Asp Leu Glu Pro Asp Ser Asn Pro Pro Gly Gly Met Phe Cys Arg Tyr 
        195                 200                 205             


Asp Arg Leu Glu Ile Trp Asp Gly Phe Pro Asp Val Gly Pro His Ile 
    210                 215                 220                 


Gly Arg Tyr Cys Gly Gln Lys Thr Pro Gly Arg Ile Arg Ser Ser Ser 
225                 230                 235                 240 


Gly Ile Leu Ser Met Val Phe Tyr Thr Asp Ser Ala Ile Ala Lys Glu 
                245                 250                 255     


Gly Phe Ser Ala Asn Tyr Ser Val Leu Gln Ser Ser Val Ser Glu Asp 
            260                 265                 270         


Phe Lys Cys Met Glu Ala Leu Gly Met Glu Ser Gly Glu Ile His Ser 
        275                 280                 285             


Asp Gln Ile Thr Ala Ser Ser Gln Tyr Ser Thr Asn Trp Ser Ala Glu 
    290                 295                 300                 


Arg Ser Arg Leu Asn Tyr Pro Glu Asn Gly Trp Thr Pro Gly Glu Asp 
305                 310                 315                 320 


Ser Tyr Arg Glu Trp Ile Gln Val Asp Leu Gly Leu Leu Arg Phe Val 
                325                 330                 335     


Thr Ala Val Gly Thr Gln Gly Ala Ile Ser Lys Glu Thr Lys Lys Lys 
            340                 345                 350         


Tyr Tyr Val Lys Thr Tyr Lys Ile Asp Val Ser Ser Asn Gly Glu Asp 
        355                 360                 365             


Trp Ile Thr Ile Lys Glu Gly Asn Lys Pro Val Leu Phe Gln Gly Asn 
    370                 375                 380                 


Thr Asn Pro Thr Asp Val Val Val Ala Val Phe Pro Lys Pro Leu Ile 
385                 390                 395                 400 


Thr Arg Phe Val Arg Ile Lys Pro Ala Thr Trp Glu Thr Gly Ile Ser 
                405                 410                 415     


Met Arg Phe Glu Val Tyr Gly Cys Lys Ile Thr Asp Tyr Pro Cys Ser 
            420                 425                 430         


Gly Met Leu Gly Met Val Ser Gly Leu Ile Ser Asp Ser Gln Ile Thr 
        435                 440                 445             


Ser Ser Asn Gln Gly Asp Arg Asn Trp Met Pro Glu Asn Ile Arg Leu 
    450                 455                 460                 


Val Thr Ser Arg Ser Gly Trp Ala Leu Pro Pro Ala Pro His Ser Tyr 
465                 470                 475                 480 


Ile Asn Glu Trp Leu Gln Ile Asp Leu Gly Glu Glu Lys Ile Val Arg 
                485                 490                 495     


Gly Ile Ile Ile Gln Gly Gly Lys His Arg Glu Asn Lys Val Phe Met 
            500                 505                 510         


Arg Lys Phe Lys Ile Gly Tyr Ser Asn Asn Gly Ser Asp Trp Lys Met 
        515                 520                 525             


Ile Met Asp Asp Ser Lys Arg Lys Ala Lys Ser Phe Glu Gly Asn Asn 
    530                 535                 540                 


Asn Tyr Asp Thr Pro Glu Leu Arg Thr Phe Pro Ala Leu Ser Thr Arg 
545                 550                 555                 560 


Phe Ile Arg Ile Tyr Pro Glu Arg Ala Thr His Gly Gly Leu Gly Leu 
                565                 570                 575     


Arg Met Glu Leu Leu Gly Cys Glu Val Glu Ala Pro Thr Ala Gly Pro 
            580                 585                 590         


Thr Thr Pro Asn Gly Asn Leu Val Asp Glu Cys Asp Asp Asp Gln Ala 
        595                 600                 605             


Asn Cys His Ser Gly Thr Gly Asp Asp Phe Gln Leu Thr Gly Gly Thr 
    610                 615                 620                 


Thr Val Leu Ala Thr Glu Lys Pro Thr Val Ile Asp Ser Thr Ile Gln 
625                 630                 635                 640 


Ser Glu Phe Pro Thr Tyr Gly Phe Asn Cys Glu Phe Gly Trp Gly Ser 
                645                 650                 655     


His Lys Thr Phe Cys His Trp Glu His Asp Asn His Val Gln Leu Lys 
            660                 665                 670         


Trp Ser Val Leu Thr Ser Lys Thr Gly Pro Ile Gln Asp His Thr Gly 
        675                 680                 685             


Asp Gly Asn Phe Ile Tyr Ser Gln Ala Asp Glu Asn Gln Lys Gly Lys 
    690                 695                 700                 


Val Ala Arg Leu Val Ser Pro Val Val Tyr Ser Gln Asn Ser Ala His 
705                 710                 715                 720 


Cys Met Thr Phe Trp Tyr His Met Ser Gly Ser His Val Gly Thr Leu 
                725                 730                 735     


Arg Val Lys Leu Arg Tyr Gln Lys Pro Glu Glu Tyr Asp Gln Leu Val 
            740                 745                 750         


Trp Met Ala Ile Gly His Gln Gly Asp His Trp Lys Glu Gly Arg Val 
        755                 760                 765             


Leu Leu His Lys Ser Leu Lys Leu Tyr Gln Val Ile Phe Glu Gly Glu 
    770                 775                 780                 


Ile Gly Lys Gly Asn Leu Gly Gly Ile Ala Val Asp Asp Ile Ser Ile 
785                 790                 795                 800 


Asn Asn His Ile Ser Gln Glu Asp Cys Ala Lys Pro Ala Asp Leu Asp 
                805                 810                 815     


Lys Lys Asn Pro Glu Ile Lys Ile Asp Glu Thr Gly Ser Thr Pro Gly 
            820                 825                 830         


Tyr Glu Gly Glu Gly Glu Gly Asp Lys Asn Ile Ser Arg Lys Pro Gly 
        835                 840                 845             


Asn Val Leu Lys Thr Leu Asp Pro Ile Leu Ile Thr Ile Ile Ala Met 
    850                 855                 860                 


Ser Ala Leu Gly Val Leu Leu Gly Ala Val Cys Gly Val Val Leu Tyr 
865                 870                 875                 880 


Cys Ala Cys Trp His Asn Gly Met Ser Glu Arg Asn Leu Ser Ala Leu 
                885                 890                 895     


Glu Asn Tyr Asn Phe Glu Leu Val Asp Gly Val Lys Leu Lys Lys Asp 
            900                 905                 910         


Lys Leu Asn Thr Gln Ser Thr Tyr Ser Glu Ala 
        915                 920             


<210>  43
<211>  3997
<212>  DNA
<213>  Homo sapiens

<400>  43
tctcaggggc cgcggccggg gctggagaac gctgctgctc cgctcgcctg ccccgctaga       60

ttcggcgctg cccgccccct gcagcctgtg ctgcagctgc cggccaccgg agggggcgaa      120

caaacaaacg tcaacctgtt gtttgtcccg tcaccattta tcagctcagc accacaagga      180

agtgcggcac ccacacgcgc tcggaaagtt cagcatgcag gaagtttggg gagagctcgg      240

cgattagcac agcgacccgg gccagcgcag ggcgagcgca ggcggcgaga gcgcagggcg      300

gcgcggcgtc ggtcccggga gcagaacccg gctttttctt ggagcgacgc tgtctctagt      360

cgctgatccc aaatgcaccg gctcatcttt gtctacactc taatctgcgc aaacttttgc      420

agctgtcggg acacttctgc aaccccgcag agcgcatcca tcaaagcttt gcgcaacgcc      480

aacctcaggc gagatgagag caatcacctc acagacttgt accgaagaga tgagaccatc      540

caggtgaaag gaaacggcta cgtgcagagt cctagattcc cgaacagcta ccccaggaac      600

ctgctcctga catggcggct tcactctcag gagaatacac ggatacagct agtgtttgac      660

aatcagtttg gattagagga agcagaaaat gatatctgta ggtatgattt tgtggaagtt      720

gaagatatat ccgaaaccag taccattatt agaggacgat ggtgtggaca caaggaagtt      780

cctccaagga taaaatcaag aacgaaccaa attaaaatca cattcaagtc cgatgactac      840

tttgtggcta aacctggatt caagatttat tattctttgc tggaagattt ccaacccgca      900

gcagcttcag agaccaactg ggaatctgtc acaagctcta tttcaggggt atcctataac      960

tctccatcag taacggatcc cactctgatt gcggatgctc tggacaaaaa aattgcagaa     1020

tttgatacag tggaagatct gctcaagtac ttcaatccag agtcatggca agaagatctt     1080

gagaatatgt atctggacac ccctcggtat cgaggcaggt cataccatga ccggaagtca     1140

aaagttgacc tggataggct caatgatgat gccaagcgtt acagttgcac tcccaggaat     1200

tactcggtca atataagaga agagctgaag ttggccaatg tggtcttctt tccacgttgc     1260

ctcctcgtgc agcgctgtgg aggaaattgt ggctgtggaa ctgtcaactg gaggtcctgc     1320

acatgcaatt cagggaaaac cgtgaaaaag tatcatgagg tattacagtt tgagcctggc     1380

cacatcaaga ggaggggtag agctaagacc atggctctag ttgacatcca gttggatcac     1440

catgaacgat gtgattgtat ctgcagctca agaccacctc gataagagaa tgtgcacatc     1500

cttacattaa gcctgaaaga acctttagtt taaggagggt gagataagag acccttttcc     1560

taccagcaac caaacttact actagcctgc aatgcaatga acacaagtgg ttgctgagtc     1620

tcagccttgc tttgttaatg ccatggcaag tagaaaggta tatcatcaac ttctatacct     1680

aagaatatag gattgcattt aataatagtg tttgaggtta tatatgcaca aacacacaca     1740

gaaatatatt catgtctatg tgtatataga tcaaatgttt tttttggtat atataaccag     1800

gtacaccaga gcttacatat gtttgagtta gactcttaaa atcctttgcc aaaataaggg     1860

atggtcaaat atatgaaaca tgtctttaga aaatttagga gataaattta tttttaaatt     1920

ttgaaacaca aaacaatttt gaatcttgct ctcttaaaga aagcatcttg tatattaaaa     1980

atcaaaagat gaggctttct tacatataca tcttagttga ttattaaaaa aggaaaaata     2040

tggtttccag agaaaaggcc aatacctaag cattttttcc atgagaagca ctgcatactt     2100

acctatgtgg actataataa cctgtctcca aaaccatgcc ataataatat aagtgcttta     2160

gaaattaaat cattgtgttt tttatgcatt ttgctgaggc atgcttattc atttaacacc     2220

tatctcaaaa acttacttag aaggtttttt attatagtcc tacaaaagac aatgtataag     2280

ctgtaacaga attttgaatt gtttttcttt gcaaaacccc tccacaaaag caaatccttt     2340

caagaatggc atgggcattc tgtatgaacc tttccagatg gtgttcagtg aaagatgtgg     2400

gtagttgaga acttaaaaag tgaacattga aacatcgacg taactggaaa ttaggtggga     2460

tatttgatag gatccatatc taataatgga ttcgaactct ccaaactaca ccaattaatt     2520

taatgtatct tgcttttgtg ttcccgtctt tttgaaatat agacatggat ttataatggc     2580

attttatatt tggcaggcca tcatagatta tttacaacct aaaagctttt gtgtatcaaa     2640

aaaatcacat tttattaatg taaatttcta atcgtatact tgctcactgt tctgatttcc     2700

tgtttctgaa ccaagtaaaa tcagtcctag aggctatggt tcttaatcta tggagcttgc     2760

tttaagaagc cagttgtcaa ttgtggtaac acaagtttgg ccctgctgtc ctactgttta     2820

atagaaaact gttttacatt ggttaatggt atttagagta attttttctc tctgcctcct     2880

ttgtgtctgt tttaaaggag actaactcca ggagtaggaa atgattcatc atcctccaaa     2940

gcaagaggct taagagagaa acaccgaaat tcagatagct cagggactgc taacagagaa     3000

ctacattttt cttattgcct tgaaagttaa aaggaaagca gatttcttca gtgactttgt     3060

ggtcctacta actacaacca gtttgggtga cagggctggt aaagtcccag tgttagatga     3120

gtgacctaaa tatacttaga tttctaagta tggtgctctc aggtccaagt tcaactattc     3180

ttaagcagtg caattcttcc cagttatttg agatgaaaga tctctgctta ttgaagatgt     3240

accttctaaa actttcctaa aagtgtctga tgtttttact caagagggga gtggtaaaat     3300

taaatactct attgttcaat tctctaaaat cccagaacac aatcagaaat agctcaggca     3360

gacactaata attaagaacg ctcttcctct tcataactgc tttgcaagtt tcctgtgaaa     3420

acatcagttt cctgtaccaa agtcaaaatg aacgttacat cactctaacc tgaacagctc     3480

acaatgtagc tgtaaatata aaaaatgaga gtgttctacc cagttttcaa taaaccttcc     3540

aggctgcaat aaccagcaag gttttcagtt aaagccctat ctgcactttt tatttattag     3600

ctgaaatgta agcaggcata ttcactcact tttctttgcc tttcctgaga gttttattaa     3660

aacttctccc ttggttacct gttatctttt gcacttctaa catgtagcca ataaatctat     3720

ttgatagcca tcaaaggaat aaaaagctgg ccgtacaaat tacatttcaa aacaaaccct     3780

aataaatcca catttccgca tggctcattc acctggaata atgcctttta ttgaatatgt     3840

tcttataggg caaaacactt tcataagtag agttttttat gttttttgtc atatcggtaa     3900

catgcagctt tttcctctca tagcattttc tatagcgaat gtaatatgcc tcttatcttc     3960

atgaaaaata aatattgctt ttgaacaaaa ctaaaaa                              3997


<210>  44
<211>  370
<212>  PRT
<213>  Homo sapiens

<400>  44

Met His Arg Leu Ile Phe Val Tyr Thr Leu Ile Cys Ala Asn Phe Cys 
1               5                   10                  15      


Ser Cys Arg Asp Thr Ser Ala Thr Pro Gln Ser Ala Ser Ile Lys Ala 
            20                  25                  30          


Leu Arg Asn Ala Asn Leu Arg Arg Asp Glu Ser Asn His Leu Thr Asp 
        35                  40                  45              


Leu Tyr Arg Arg Asp Glu Thr Ile Gln Val Lys Gly Asn Gly Tyr Val 
    50                  55                  60                  


Gln Ser Pro Arg Phe Pro Asn Ser Tyr Pro Arg Asn Leu Leu Leu Thr 
65                  70                  75                  80  


Trp Arg Leu His Ser Gln Glu Asn Thr Arg Ile Gln Leu Val Phe Asp 
                85                  90                  95      


Asn Gln Phe Gly Leu Glu Glu Ala Glu Asn Asp Ile Cys Arg Tyr Asp 
            100                 105                 110         


Phe Val Glu Val Glu Asp Ile Ser Glu Thr Ser Thr Ile Ile Arg Gly 
        115                 120                 125             


Arg Trp Cys Gly His Lys Glu Val Pro Pro Arg Ile Lys Ser Arg Thr 
    130                 135                 140                 


Asn Gln Ile Lys Ile Thr Phe Lys Ser Asp Asp Tyr Phe Val Ala Lys 
145                 150                 155                 160 


Pro Gly Phe Lys Ile Tyr Tyr Ser Leu Leu Glu Asp Phe Gln Pro Ala 
                165                 170                 175     


Ala Ala Ser Glu Thr Asn Trp Glu Ser Val Thr Ser Ser Ile Ser Gly 
            180                 185                 190         


Val Ser Tyr Asn Ser Pro Ser Val Thr Asp Pro Thr Leu Ile Ala Asp 
        195                 200                 205             


Ala Leu Asp Lys Lys Ile Ala Glu Phe Asp Thr Val Glu Asp Leu Leu 
    210                 215                 220                 


Lys Tyr Phe Asn Pro Glu Ser Trp Gln Glu Asp Leu Glu Asn Met Tyr 
225                 230                 235                 240 


Leu Asp Thr Pro Arg Tyr Arg Gly Arg Ser Tyr His Asp Arg Lys Ser 
                245                 250                 255     


Lys Val Asp Leu Asp Arg Leu Asn Asp Asp Ala Lys Arg Tyr Ser Cys 
            260                 265                 270         


Thr Pro Arg Asn Tyr Ser Val Asn Ile Arg Glu Glu Leu Lys Leu Ala 
        275                 280                 285             


Asn Val Val Phe Phe Pro Arg Cys Leu Leu Val Gln Arg Cys Gly Gly 
    290                 295                 300                 


Asn Cys Gly Cys Gly Thr Val Asn Trp Arg Ser Cys Thr Cys Asn Ser 
305                 310                 315                 320 


Gly Lys Thr Val Lys Lys Tyr His Glu Val Leu Gln Phe Glu Pro Gly 
                325                 330                 335     


His Ile Lys Arg Arg Gly Arg Ala Lys Thr Met Ala Leu Val Asp Ile 
            340                 345                 350         


Gln Leu Asp His His Glu Arg Cys Asp Cys Ile Cys Ser Ser Arg Pro 
        355                 360                 365             


Pro Arg 
    370 


<210>  45
<211>  1620
<212>  DNA
<213>  Homo sapiens

<400>  45
agtccggggc ggcgcctgga ggcggagccg cccgctgggc taaatggggc agaggccggg       60

aggggtgggg gttccccgcg ccgcagccat ggagcagctt cgcgccgccg cccgtctgca      120

gattgttctg ggccacctcg gccgcccctc ggccggggct gtcgtagctc atcccacttc      180

agggactatt tcctctgcca gtttccatcc tcaacaattc cagtatactc tggataataa      240

cgttctaacc ctggaacaga gaaaatttta tgaagaaaat gggtttctag taatcaaaaa      300

tcttgtacct gatgccgata ttcaacgctt tcggaatgag tttgaaaaaa tctgcagaaa      360

ggaggtgaaa ccattaggat taacagtaat gagagatgtg accatttcga aatccgaata      420

tgctccaagt gagaagatga tcacgaaggt ccaggatttc caggaagata aggagctctt      480

cagatactgc actctccccg agattctgaa atatgtggag tgcttcactg gacctaatat      540

tatggccatg cacacaatgt tgataaacaa acctccagat tctggcaaga agacgtcccg      600

tcaccccctg caccaggacc tgcactattt ccccttcagg cccagcgatc tcatcgtttg      660

cgcctggacg gcgatggagc acatcagccg gaacaacggc tgtctggttg tgctcccagg      720

cacacacaag ggctccctga agccccacga ttaccccaag tgggaggggg gagttaacaa      780

aatgttccac gggatccagg actacgagga aaacaaggcc cgggtgcacc tggtgatgga      840

gaagggcgac actgttttct tccatccttt gctcatccac ggatctggtc agaataaaac      900

ccagggattc cggaaggcaa tttcctgcca tttcgccagt gccgattgcc actacattga      960

cgtgaagggc accagtcaag aaaacatcga gaaggaagtt gtaggaatag cacataaatt     1020

ctttggagct gaaaatagcg tgaacttgaa ggatatttgg atgtttcgag ctcgacttgt     1080

gaaaggagaa agaaccaatc tttgaaatag ccatctgcta taactctttc aacagaaaac     1140

caaaaccaaa cgaaatgtct aaggaaaatg ttttcttaat gagatgatgt aaccttttct     1200

atcacttgtt aaaagcagaa aacatgtatc aggtacttaa ttgcatagag ttagttttgc     1260

agcacaatgg tgttgcttta atggaaaaaa aaaacagtaa aagtgaaata ttactgtttt     1320

aaggaaaact aatttagggt ggcagccaat aaaggtggtt ggtgtctaat ttaagtgtta     1380

aatcaatttc tttcattcag ttagctcttt acccaagaag aagtgaatga tttggagctt     1440

agggtatgtt ttgtatcccc tttctgataa acccattccc taccaatttt atgtcataag     1500

agattttttt cccccaaatc tagaacaatg tataatacat tcacatctag tcaagggcat     1560

aggaacggtg tcatggagtc caaataaagt ggatattcct gctcggacaa aaaaaaaaaa     1620


<210>  46
<211>  338
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Glu Gln Leu Arg Ala Ala Ala Arg Leu Gln Ile Val Leu Gly His 
1               5                   10                  15      


Leu Gly Arg Pro Ser Ala Gly Ala Val Val Ala His Pro Thr Ser Gly 
            20                  25                  30          


Thr Ile Ser Ser Ala Ser Phe His Pro Gln Gln Phe Gln Tyr Thr Leu 
        35                  40                  45              


Asp Asn Asn Val Leu Thr Leu Glu Gln Arg Lys Phe Tyr Glu Glu Asn 
    50                  55                  60                  


Gly Phe Leu Val Ile Lys Asn Leu Val Pro Asp Ala Asp Ile Gln Arg 
65                  70                  75                  80  


Phe Arg Asn Glu Phe Glu Lys Ile Cys Arg Lys Glu Val Lys Pro Leu 
                85                  90                  95      


Gly Leu Thr Val Met Arg Asp Val Thr Ile Ser Lys Ser Glu Tyr Ala 
            100                 105                 110         


Pro Ser Glu Lys Met Ile Thr Lys Val Gln Asp Phe Gln Glu Asp Lys 
        115                 120                 125             


Glu Leu Phe Arg Tyr Cys Thr Leu Pro Glu Ile Leu Lys Tyr Val Glu 
    130                 135                 140                 


Cys Phe Thr Gly Pro Asn Ile Met Ala Met His Thr Met Leu Ile Asn 
145                 150                 155                 160 


Lys Pro Pro Asp Ser Gly Lys Lys Thr Ser Arg His Pro Leu His Gln 
                165                 170                 175     


Asp Leu His Tyr Phe Pro Phe Arg Pro Ser Asp Leu Ile Val Cys Ala 
            180                 185                 190         


Trp Thr Ala Met Glu His Ile Ser Arg Asn Asn Gly Cys Leu Val Val 
        195                 200                 205             


Leu Pro Gly Thr His Lys Gly Ser Leu Lys Pro His Asp Tyr Pro Lys 
    210                 215                 220                 


Trp Glu Gly Gly Val Asn Lys Met Phe His Gly Ile Gln Asp Tyr Glu 
225                 230                 235                 240 


Glu Asn Lys Ala Arg Val His Leu Val Met Glu Lys Gly Asp Thr Val 
                245                 250                 255     


Phe Phe His Pro Leu Leu Ile His Gly Ser Gly Gln Asn Lys Thr Gln 
            260                 265                 270         


Gly Phe Arg Lys Ala Ile Ser Cys His Phe Ala Ser Ala Asp Cys His 
        275                 280                 285             


Tyr Ile Asp Val Lys Gly Thr Ser Gln Glu Asn Ile Glu Lys Glu Val 
    290                 295                 300                 


Val Gly Ile Ala His Lys Phe Phe Gly Ala Glu Asn Ser Val Asn Leu 
305                 310                 315                 320 


Lys Asp Ile Trp Met Phe Arg Ala Arg Leu Val Lys Gly Glu Arg Thr 
                325                 330                 335     


Asn Leu 
        


<210>  47
<211>  9369
<212>  DNA
<213>  Homo sapiens

<400>  47
ctgtgggtag gcggcggcgg cggcggctac gcggagcggc aggcggtgga gcgaggccgc       60

gcgcgccgaa gatggctgag aagcagaagc acgacgggcg ggtgaagatc ggacactacg      120

tgctgggcga cacgctgggc gtcggcacct tcggcaaagt gaagattgga gaacatcaat      180

taacaggcca taaagtggca gttaaaatct taaatagaca gaagattcgc agtttagatg      240

ttgttggaaa aataaaacga gaaattcaaa atctaaaact ctttcgtcat cctcatatta      300

tcaaactata ccaggtgatc agcactccaa cagatttttt tatggtaatg gaatatgtgt      360

ctggaggtga attatttgac tacatctgta agcatggacg ggttgaagag atggaagcca      420

ggcggctctt tcagcagatt ctgtctgctg tggattactg tcataggcat atggttgttc      480

atcgagacct gaaaccagag aatgtcctgt tggatgcaca catgaatgcc aagatagccg      540

atttcggatt atctaatatg atgtcagatg gtgaatttct gagaactagt tgcggatctc      600

caaattatgc agcacctgaa gtcatctcag gcagattgta tgcaggtcct gaagttgata      660

tctggagctg tggtgttatc ttgtatgctc ttctttgtgg caccctccca tttgatgatg      720

agcatgtacc tacgttattt aagaagatcc gagggggtgt cttttatatc ccagaatatc      780

tcaatcgttc tgtcgccact ctcctgatgc atatgctgca ggttgaccca ctgaaacgag      840

caactatcaa agacataaga gagcatgaat ggtttaaaca agatttgccc agttacttat      900

ttcctgaaga cccttcctat gatgctaacg tcattgatga tgaggctgtg aaagaagtgt      960

gtgaaaaatt tgaatgtaca gaatcagaag taatgaacag tttatatagt ggtgaccctc     1020

aagaccagct tgcagtggct tatcatctta tcattgacaa tcggagaata atgaaccaag     1080

ccagtgagtt ctacctcgcc tctagtcctc catctggttc ttttatggat gatagtgcca     1140

tgcatattcc cccaggcctg aaacctcatc cagaaaggat gccacctctt atagcagaca     1200

gccccaaagc aagatgtcca ttggatgcac tgaatacgac taagcccaaa tctttagctg     1260

tgaaaaaagc caagtggcat cttggaatcc gaagtcagag caaaccgtat gacattatgg     1320

ctgaagttta ccgagctatg aagcagctgg attttgaatg gaaggtagtg aatgcatacc     1380

atcttcgtgt aagaagaaaa aatccagtga ctggcaatta cgtgaaaatg agcttacaac     1440

tttacctggt tgataacagg agctatcttt tggactttaa aagcattgat gatgaagtag     1500

tggagcagag atctggttcc tcaacacctc agcgttcctg ttctgctgct ggcttacaca     1560

gaccaagatc aagttttgat tccacaactg cagagagcca ttcactttct ggctctctca     1620

ctggctcttt gaccggaagc acattgtctt cagtttcacc tcgcctgggc agtcacacca     1680

tggatttttt tgaaatgtgt gccagtctga ttactacttt agcccgttga tctgtctcta     1740

gtttctttct gttattgcac tatgaaaatc agttatattc tttaaatttt tatcttactt     1800

ttggataata tccactgcaa tactaattga gaaacatgaa ttatttccag gggcacacaa     1860

tgctattgaa attactgaaa acaaaatatc tgacatctta tttacttgta gaaatctgta     1920

attctattgt gcctatgata aattcacata ggcaatatct ttaataggtt aatatcaatg     1980

aagattttta attacaataa tgagttcact acagacgatt aacacaccac actggcgaac     2040

catctcaatg taagggtggt ttggcaacac ctccttgctt tgctgtttgg tgtaggtaaa     2100

tctagtttac ttcctaaatt tcagtaggct ttatgctgtg tttatgcccc caatttattt     2160

taacaaaaga agattaaaaa gtaaaagaac cacgagtaag atattattta aatgttgaaa     2220

tcttaaaaac ctgcctccaa gatttcagaa gccaagtttt tctaacagta tttgtacaaa     2280

tactgcctag tgtattcaac agaaggactg tggtcatgta acaggtaacc acaattttca     2340

ggtttcttaa aaacagctgt aactaactca ggatttttat cttgagattt ccctgaataa     2400

tatatttatc ttaagagcct tcaagtttca aattaatatt ggaacatctg gaattgcaac     2460

aacttttgtc ttttacataa acttacgtca tttaaaaaat gtcttcaaaa tctacctttc     2520

tcaaattctt tttgcctcta tttatttttg catttcacca acagtgataa aatagttaaa     2580

tgaaacaaag caaagtatca acagtccctt aaatgagaat ccttatcttt gatctttatt     2640

ttctgtgtta ggtgttaggg tcctggtgca gctcataatg ctaattcttc attggaagcc     2700

actcccttca cctcacctca cctagtcact attgtctttg ttcattgttt gatcctgagt     2760

ggttgattga tatagctttg aatcttttct agtccaagtt tgaaaacact gttctggccc     2820

taagggctgg ctatgacctt tactgttgaa cctgataggg cagggaagct ttgaacatca     2880

agaaaaaatt tttatcttaa ataaataaat atatatattc acacaccagt gcttttaagc     2940

aaaaaccagt ttttttgttt gtttgttttg ctttgtgcag gttttcttta agattaaaaa     3000

aacacaaact atagcagggt agataatagt ttattgatta tattttgttt tagtaaaagt     3060

atttaatttt aaattctgtg taatttatct aatttgtatt tattcatttg ttatttttat     3120

gttgtaatta acacttattt acctggatta ccctaaaaaa attaagctct tgaaaacaaa     3180

aaaatgacat taccttgaca ggcttctctt tgccaaaagt aatgtatgtt ctgccaagaa     3240

gcaaatgaga atgttagact aagtttctcc tgtgttagtg gaaaacaagt gtgtctatct     3300

ttaaatattc tttgaatcag gagtttgcgt tgtgtcacat catatggctt tgcagatctt     3360

ttaaaaactg atgttaaata acttataagt ccaacttctt aatatcaaga taaatgaata     3420

gttcaccaat ttgggaagga gggcgggttg caatttgaga tagtttaagg tttaattatt     3480

gaaagactgc catcttgtgg caccaaaagg taatttttac atgattattt gtatagtgat     3540

aagcagtcct gctgtgttag cctggtccat tatagatatg gcatagtttt gggttctcta     3600

aatgggtcca tacctctttt gggaaaaaac agggccacct cataatattt gcctgattat     3660

gaatggaatt accttagaaa taaggaacta atcagattac ttaaccccaa tgacaaaatc     3720

cacaaaaatt ttgaaggcag agaaacagaa ggaatccagt gatgttttag ctccattagt     3780

ctaataggtc agatattaaa aaattgttca tatcaaaatt accttatatg gattattgcc     3840

atgttttttg agagttaatt atttactgtt ttctaattct tgccagtatt tatgaacagc     3900

tgtagcttga tatttaccta ctgaatttta ggagaactaa tggtcacagt ttgggttctt     3960

ttatgtgtat gtttttaaaa cagctatttt gtgaatctag gtggttggtt tttagaagat     4020

ttcaggagat gcagtccagc acaattagag ctggaacatt gttacagcag gctttttgtt     4080

gctcatgggc agatagaggg aaagaatcag ttgttagccc caaatttcca catttcagtg     4140

ttgtaaactc tgaatgtgat aggtagatgt gggctaagaa taatttcctc cagtgaagac     4200

acgggagaag agcttctatt atgaggttat agataaggcc ttagttatat catggaaatg     4260

gactccatgt agttctagaa ctgcatttcc caaagtatat cctgtgagat gctccacaga     4320

aaaaatgatt gcatggacta agtttgaaaa atgttgcatg ctactcttcc cctcgaagat     4380

gacagtggat gtcagcatta aagactttga caggtctttc tgtgaaaaaa agaaagccac     4440

ataactttgt tgaactttgc ccaaattaat ttttcatttt aaaaaactta atagcccatg     4500

aaaagcaaat ttgggaaata cattttttag gaaaatactg tcccagaatg ccataattag     4560

ggtagttaat aattaacact tccatttctc ttactggttg ttgggagaat ctgattgaaa     4620

attagaatta ctttgtttta acttgcagac atgttcatcg tgagtgaatg ctggattaaa     4680

tagaattttc tgtgtctgca acttgtttca tgacaccttg gttttcttaa tcatcttgta     4740

ttattatttg agtgcaacat tattcttatg catgggtgac tgaaaaacct gaaacaagat     4800

tacttgttaa aaaaaagtct aagagactaa tgactcatgc ttatggctca gtgggtaatg     4860

aatcagtgtc actgattctt acttttaaaa tgtgtagtca gtgaacattt tctaaatact     4920

tttctttggg ataccatatg aagatctaat tccttatgtt tcagtgtagg aacagctacc     4980

ttctcaaata gaatatgcag ggagggaagt aggcaaacca tttacaagtt gggtttttgt     5040

tttgattaac ctgttaagag acacttttgt aatctctagt gtttacattc ctttatacta     5100

gctatctata aagagaatcc agaaggctaa attaatcaga aataattata tttctatgtc     5160

agggtattgg ctatatgtag catgaacaat tctccatttt ctgcaaatgg gtttttcagg     5220

acagttttat aattctgagt ttgctttttc ttattcccta gacagtttgt actcagggaa     5280

tacaaattga tttttactgt taaatgagac atagtttaga aaaaatcata agcaactatt     5340

gtagattttt gatctgtttg gatttatctg tagcattgaa taatgtgcag tgtactgagt     5400

taatgtaggc acctcacttt ggatttataa aatgtaaaaa cctggaacat gcctgccaca     5460

gacaccactt tgtctattca ccgggtacta atttacatcc tattaatggt tgtaaaagct     5520

gagtgtctaa atgctagaca tgttcacaat tttgtctgtt tttgtttatt tgtttttaag     5580

acccaaacct tttcaatctt gcatttattt acttggttct cctgtgtcac cctgtggctt     5640

tttaaatagg gaatgtaatt tattttaata gtagttctca aagactctat taaaaactct     5700

ggacgaggga tatgtgcaat ctgttggtaa gtcacatcct atgtttggcc tcatttttat     5760

aactcctaaa atgagaaagg tagattttaa cacttctaag gtacctttga gctttaaagt     5820

tcttttctgc ttttccatat gatttgtgtt agtgttcact ttttatatat ttagagtttt     5880

tatatgagtg tgaatgtttc tgttttgatt tggtgaggca tgtcagaggt atatacttga     5940

atatttttct aaatacagct gctggaggaa tgcaaatggc aaaaatcatc cagaaaacca     6000

aacacggtga aacatcacat ccatttggca tgaagcaaag cattacaaat ttggagtgat     6060

gaaagtgttc catatatttt ttatagtgat ttttcgatct agagaccctt catattgttt     6120

acttactatt acgataactt tgagaggtaa ccagagaaag catttttgcc atttccagat     6180

gaggaagcag gaccagaaag ctcttcataa agctttaaca ccatacaagt atccagcagt     6240

gatcaattgc tctttatagg aaaccacctt tcctctgggg aagaacagtc tgaattaata     6300

aaacatcaga gtggttgagt agtaaaaata aacacagatg tattgctttc aagtcttaga     6360

gtgacataaa gtagtcttaa ataaatagtt cttagtttat tttaagcagt tgattgtact     6420

aacgagatgt aattatctga agtatttatg attagcatat tggtttttat aagtatttct     6480

gagttattga gggtgcttaa aaatgctgaa gaaactttaa aacatgattc ttcttataat     6540

tttatgtgat tcttatagca caatcatttt tgaaaaagga aaactaggct gggtgtagtg     6600

gctcatgcct ataatcccag cactttggga ggccaaagtg ggtggatcac ccgagttcag     6660

gagttcgaga ccagtctggc caacatggtg aaacctcgtc tctactaaaa ataccaaaat     6720

tatccggtgt ggtgacaggc tgcttgtaat cccagctact cgggaggctg aggcacggga     6780

atctcttgaa cctgggaggc agagattgca ataagccaag atcatgccac tgcatgccag     6840

cctgggtgac agcacaagac tgtctcaaaa aaaaacaaaa aaaggaaaaa gaaaactagc     6900

cccagtccct gtctaaattg ttatagtttt tgactattat ctgaattagt cttatccaaa     6960

tttcatatgc agattgattt ttcattttgt atgtatatta catgatataa ctattttcat     7020

agaatatatt tctaatttac aaacactgaa ttattagctt gatagagttt ctcccaaacc     7080

ttataaaact ttgaaatgta cttatgtttg agctttaaaa attataaaaa cttcatttaa     7140

acaagttgct ggcatcatta ctagcctttc cacctataat tatgatgcat ttgatgccac     7200

tgaacagtaa tagcacaaag aacaggtcac acagtctaga ctggattgag ttttaattaa     7260

acttcttcat ccatagcctg ataagaatca ggctgggtct agaagagtta tcagactgta     7320

ggcctgtatt aattttgcaa gctaatgtta atgtttactg ccagccttgc atagcaatgc     7380

cagtttgcag ttgtgactat gatgtgactt ttggtaaaaa tggtttatat ctaaagtagt     7440

ttagatttta tggaagtggc tcttgattgt ttggacaagc agggtaggta aatttcaatt     7500

acgtttgaag tgtaattaaa tcctagaata gagcactctc cagaaaaaaa aatgaaaaaa     7560

gaatttggag aatatcctgg catgaaaact tttttgaata atacgtagaa ttttgacaag     7620

gttcatacag tgcatacagt gtgacctttt ctgaggtggg cagggagggt tgctacgttg     7680

tgttgattta aaatttcaag gaggaacaaa aacattctag ccaaggagaa ttgcattgtt     7740

attttttttt ctactaattt aaacgtgcat ttttcacagt tacacattta agttttgcta     7800

ccaaaaatgg ccatttttct agacagataa cattttccta aagtggaaga gagatccact     7860

gttctaaaaa aaaaaaaaaa aaaaaacact aaattgtgcc ttctccctta aattataaga     7920

agagtaatag taaaaacttg tttaaactat attttctttt tttctaatcc ctctcagttc     7980

tccttagatc tgcctcctac aaatgatcat gttgtttgca tctgcctgat tgagttccct     8040

tggtcaaacc tctccctatc actatcagaa gttgttcact aaatgtattt tcctatttct     8100

ttcatgttga ttgactttat aagtcacctt ggtaaacata acatttggct accttctcat     8160

gctttataaa tgaatttgat gaatggcagt ttttatattt taacccttta aaaagtttgt     8220

caaggaaaca actcagagct aagaacaaaa tctaacttgg aatcagtttc ttcctttggc     8280

tgctgaagca gcagcaagtc acgtaacctc atttagtttt ttgatttaca aaatgtggat     8340

aataacctac ctcacagatg tgtgtgagca actgtttgaa agcccttgtt taaatacagg     8400

gtttatatcc ccacattcaa tgtaaattcc tttttttaaa aaaaataagt atctttgata     8460

ctgataggat gagtatcttg atttttaggt aagatcacag tttcacaaat tgtggtgttg     8520

ttaggtgaca tttaatattt cttgagacct caagtattca aatatcaaac ttgtcctgtg     8580

ttgtaacaaa tattcagaat ctcttaaaat gttggctgaa gctgccttaa tgtaccaaaa     8640

tacagctctc aagactgttc acaaatatct gtggttgtac aatgttttga acatttaatg     8700

taaagttgtt gtagaactgt gaactctaag gatagtatct ttattgtttt aggaagaatg     8760

gttgtgttct ttgtcatgta tgcttaaata tacagtggat tttgaatgca acaaataaaa     8820

ctgaaaacag ccatttggtt gtgtcatgac aatcataata taggatataa tatttacttt     8880

ttttcaaaaa catcctgcat tcattcattc ttagcatacc tttgaaaaag aaaaaaaaat     8940

ccataggttg atacattgac ccattgaagt acttcattac gtatttattg aaaatttttt     9000

ttaattgttg aaattgggac cactttttat aattggtttc aagaaaaaaa aatgaacaga     9060

cttccagtgc ttttctgttc aaataaactc cgattcaaat ttcagttttg tttgttatat     9120

actttttgtg agtgttaaat gatatgggaa ggatttgtct ttcattaacc atatggaaaa     9180

gatgtcttcc tgaattacat agcatttcat agttacagat tcttcctaat taatgtttgc     9240

accatatgaa actcataggt aacaaacaca aaggagaaaa gcagcctgtc tgattgctta     9300

taagcttttt tcacaaaatc aaattaaaag tctctgattc atttgaaagc taaaaaaaaa     9360

aaaaaaaaa                                                             9369


<210>  48
<211>  552
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Ala Glu Lys Gln Lys His Asp Gly Arg Val Lys Ile Gly His Tyr 
1               5                   10                  15      


Val Leu Gly Asp Thr Leu Gly Val Gly Thr Phe Gly Lys Val Lys Ile 
            20                  25                  30          


Gly Glu His Gln Leu Thr Gly His Lys Val Ala Val Lys Ile Leu Asn 
        35                  40                  45              


Arg Gln Lys Ile Arg Ser Leu Asp Val Val Gly Lys Ile Lys Arg Glu 
    50                  55                  60                  


Ile Gln Asn Leu Lys Leu Phe Arg His Pro His Ile Ile Lys Leu Tyr 
65                  70                  75                  80  


Gln Val Ile Ser Thr Pro Thr Asp Phe Phe Met Val Met Glu Tyr Val 
                85                  90                  95      


Ser Gly Gly Glu Leu Phe Asp Tyr Ile Cys Lys His Gly Arg Val Glu 
            100                 105                 110         


Glu Met Glu Ala Arg Arg Leu Phe Gln Gln Ile Leu Ser Ala Val Asp 
        115                 120                 125             


Tyr Cys His Arg His Met Val Val His Arg Asp Leu Lys Pro Glu Asn 
    130                 135                 140                 


Val Leu Leu Asp Ala His Met Asn Ala Lys Ile Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ser Asn Met Met Ser Asp Gly Glu Phe Leu Arg Thr Ser Cys Gly Ser 
                165                 170                 175     


Pro Asn Tyr Ala Ala Pro Glu Val Ile Ser Gly Arg Leu Tyr Ala Gly 
            180                 185                 190         


Pro Glu Val Asp Ile Trp Ser Cys Gly Val Ile Leu Tyr Ala Leu Leu 
        195                 200                 205             


Cys Gly Thr Leu Pro Phe Asp Asp Glu His Val Pro Thr Leu Phe Lys 
    210                 215                 220                 


Lys Ile Arg Gly Gly Val Phe Tyr Ile Pro Glu Tyr Leu Asn Arg Ser 
225                 230                 235                 240 


Val Ala Thr Leu Leu Met His Met Leu Gln Val Asp Pro Leu Lys Arg 
                245                 250                 255     


Ala Thr Ile Lys Asp Ile Arg Glu His Glu Trp Phe Lys Gln Asp Leu 
            260                 265                 270         


Pro Ser Tyr Leu Phe Pro Glu Asp Pro Ser Tyr Asp Ala Asn Val Ile 
        275                 280                 285             


Asp Asp Glu Ala Val Lys Glu Val Cys Glu Lys Phe Glu Cys Thr Glu 
    290                 295                 300                 


Ser Glu Val Met Asn Ser Leu Tyr Ser Gly Asp Pro Gln Asp Gln Leu 
305                 310                 315                 320 


Ala Val Ala Tyr His Leu Ile Ile Asp Asn Arg Arg Ile Met Asn Gln 
                325                 330                 335     


Ala Ser Glu Phe Tyr Leu Ala Ser Ser Pro Pro Ser Gly Ser Phe Met 
            340                 345                 350         


Asp Asp Ser Ala Met His Ile Pro Pro Gly Leu Lys Pro His Pro Glu 
        355                 360                 365             


Arg Met Pro Pro Leu Ile Ala Asp Ser Pro Lys Ala Arg Cys Pro Leu 
    370                 375                 380                 


Asp Ala Leu Asn Thr Thr Lys Pro Lys Ser Leu Ala Val Lys Lys Ala 
385                 390                 395                 400 


Lys Trp His Leu Gly Ile Arg Ser Gln Ser Lys Pro Tyr Asp Ile Met 
                405                 410                 415     


Ala Glu Val Tyr Arg Ala Met Lys Gln Leu Asp Phe Glu Trp Lys Val 
            420                 425                 430         


Val Asn Ala Tyr His Leu Arg Val Arg Arg Lys Asn Pro Val Thr Gly 
        435                 440                 445             


Asn Tyr Val Lys Met Ser Leu Gln Leu Tyr Leu Val Asp Asn Arg Ser 
    450                 455                 460                 


Tyr Leu Leu Asp Phe Lys Ser Ile Asp Asp Glu Val Val Glu Gln Arg 
465                 470                 475                 480 


Ser Gly Ser Ser Thr Pro Gln Arg Ser Cys Ser Ala Ala Gly Leu His 
                485                 490                 495     


Arg Pro Arg Ser Ser Phe Asp Ser Thr Thr Ala Glu Ser His Ser Leu 
            500                 505                 510         


Ser Gly Ser Leu Thr Gly Ser Leu Thr Gly Ser Thr Leu Ser Ser Val 
        515                 520                 525             


Ser Pro Arg Leu Gly Ser His Thr Met Asp Phe Phe Glu Met Cys Ala 
    530                 535                 540                 


Ser Leu Ile Thr Thr Leu Ala Arg 
545                 550         


<210>  49
<211>  5927
<212>  DNA
<213>  Homo sapiens

<400>  49
aaacaaccaa tgacctgtgc acagtttagg gcctaaccct gccctggccg gttagcaaga       60

gagtgttgtg ataagagcag atgaaagcct tatgccacag tagtgcctgt agcagagaaa      120

ggattccctc ctccacctca gggcccactg ctgctgctct ccagcctgca gtttcctcta      180

aggctctgga ttggctggaa gagcaacaga gggctgggaa agagcttcta tatatacctc      240

aggaggaaag gcatcccaga cagttttgaa gttttcaaag actggctctg ctgttaagaa      300

gttgtactta aagcggagga gctaagccac ctgccaaaat gtgcaaagga cttgcagctt      360

tgccccactc atgcctggaa agggccaagg agattaagat caagttggga attctcctcc      420

agaagccaga ctcagttggt gaccttgtca ttccgtacaa tgagaagcca gagaaaccag      480

ccaagaccca gaaaacctcg ctggacgagg ccctgcagtg gcgtgattcc ctggacaaac      540

tcctgcagaa caactatgga cttgccagtt tcaaaagttt cctgaagtct gaattcagtg      600

aggaaaacct tgagttctgg attgcctgtg aggattacaa gaagatcaag tcccctgcca      660

agatggctga gaaggcaaag caaatttatg aagaattcat tcaaacggag gctcctaaag      720

aggtgaatat tgaccacttc actaaggaca tcacaatgaa gaacctggtg gaaccttccc      780

tgagcagctt tgacatggcc cagaaaagaa tccatgccct gatggaaaag gattctctgc      840

ctcgctttgt gcgctctgag ttttatcagg agttaatcaa gtagtaattt agccaggcta      900

tgaaatcatc ctgtgagtta tttcctccat aataaccctg catttcccat taatctacat      960

atcttcccac agcagctttg ctcagtgata cccacatggg aaaaatccca ggggatgttg     1020

cttactcttt ttgcccacac tgctttggat acttatctac tgtccgaagg ccttctttcc     1080

ccactcaatt cttcctgccc tgttattaat taagatatct tcagcttgta gtcagacaca     1140

atcagaatca cagaaaaatc ctgcctaagg caaagaaata taagacaaga ctatgatatc     1200

aatgaatgtg ggttaagtaa tagatttcca gctaaattgg tctaaaaaag aatattaagt     1260

gtggacagac ctatttcaaa ggagcttaat tgatctcact tgttttagtt ctgatccagg     1320

gagatcaccc ctctaattat ttctgaactt ggttaataaa agtttataag atttttatga     1380

agcagccact gtatgatatt ttaagcaaat atgttattta aaatattgat ccttcccttg     1440

gaccaccttc atgttagttg ggtattataa ataagagata caaccatgaa tatattatgt     1500

ttatacaaaa tcaatctgaa cacaattcat aaagatttct cttttatacc ttcctcactg     1560

gccccctcca cctgcccata gtcaccaaat tctgttttaa atcaatgacc taagatcaac     1620

aatgaagtat tttataaatg tatttatgct gctagactgt gggtcaaatg tttccatttt     1680

caaattattt agaattctta tgagtttaaa atttgtaaat ttctaaatcc aatcatgtaa     1740

aatgaaactg ttgctccatt ggagtagtct cccacctaaa tatcaagatg gctatatgct     1800

aaaaagagaa aatatggtca agtctaaaat ggctaattgt cctatgatgc tattatcata     1860

gactaatgac atttatcttc aaaacaccaa attgtcttta gaaaaattaa tgtgattaca     1920

ggtagaggcc ttctaggtga gacactttta aggtacactg cattttgcaa aaaaaaaaaa     1980

aaaaagtaat cttttagcaa ccccagtatt ccttcactat ttcgcttcct gcattagcaa     2040

attttactta cagtcaaaag tgcagattta tactcctgac gtgtctcatt cacagctaaa     2100

taataggcca taggactttt ggtaggttta aacttttaat tctgtatttc atgattataa     2160

gtcttgctag aattttttct aatctttagt agatttgatt aaataatgat tcacagaatt     2220

tagtaacaga atcaaactaa gccatgtatg agggtaatcg agatgaggat attaactcaa     2280

aagaaatagg gtgattttta aaggattaat aaaattctga aatgttaagt agaagattac     2340

attgtctagt cttgtatttc ctccttctgt tgctctcttt cattcacaca ctctcagttt     2400

ctcatatttg tagctcattt atttggttat ttcctaagaa tattgaaagt gaagcaacta     2460

tgtgactgta ttcttcaggt aaacactgac tgcgcttgtt ggattttccc tatttttgtg     2520

acttcaagaa taatatgccc tgctgaatac atgccatttc acattctgaa actgggtaga     2580

gtggttgggt gttctgccaa caattgctag tggtgtgaat tcattcatat ttgccagtat     2640

tgctcacttc aaagaaactc cttcatcaag cagtccagag ctaggccaga tcaatgctac     2700

aatcatgaag ttctcattgc atgcaattgt gtaggattga caaggaactc agataaaaat     2760

ttccagggtg cacttccaga accagcttca acatatgtct acattgcccc caagttaata     2820

aagtgccaac cctttactct ctcatacagc cagaaatgtt agaaatccaa aatcttggtg     2880

cattattttt tcataaacgc taaaacattt gaagaaacaa tttaattatt taaaattcaa     2940

gtattttatt cacattattt gcaatatcca aatgtttaaa aattcccaga taattaacta     3000

gctattacag atctcaccta gagggttgat gttatgaaga ctccagtgga ctgtactcac     3060

aaattgactg gacaccctat gaaagtgggt agacctctca gcggaaaata agaagggctt     3120

ttacctacag ggcaggacag ggtcccatga gagcagttct gtggagatat aaaaagaatg     3180

gaagaaggaa tgccttatag tgatattgtg acattatatc tatatatcta catatatcta     3240

tctatctata tctacatcta tataatctta catttaaaat tgtattccta cacatattag     3300

aaactcttct aataaatgaa gtaaaaaaat taaaaagaat acaaatattc cagccccaaa     3360

tgagaaatca aacatattaa aattgttcaa gaaaatttct ttgaacactt ctgaaagttt     3420

ttggaaactt agaaaagagg gaaaaaaatc cagtgttact agtaatttcc atggtaatac     3480

agataaaata cattctttta attctgggaa attagaaaaa gtggggtgat ctttccagga     3540

aaaacatgtg taacatctgc ttatcactcc agctccctcc tcctcctcct ctccacgttc     3600

ccttgagtaa atgtctggga aagcatgaag cttgatgcaa gaaccctgtt gtactggcgt     3660

tttcctcccc tgtgaaaacg taactactgt tgggagtgaa ttgaggatgt agaaaggtgg     3720

tggaaccaaa ttgtggtcaa tggaaatagg agaatatggt tctcactctt gagaaaaaaa     3780

cctaagatta gcccaggtag ttgcctgtaa cttcagtttt tctgcctggg tttgatatag     3840

tttagggttg gggttagatt aagatctaaa ttacatcagg acaaagagac agactattaa     3900

ctccacagtt aattaaggac gtatgttcca tgtttatttg ttaaagcagt gtgaatagcc     3960

ttcaagcatg tgaataatct tccatcttcc ccgccacaca tacacacaca cactttttgt     4020

ttctttcagg tagacacctt ttaaaatgca gaactaactg aggcatttca gtaactttgc     4080

tttcaaatca ataaagtcaa atgtatggaa acattttgtg ccctactctc cataccccgt     4140

gtactcaaat tctctactgt atgaattatg ctttaagtag aattcagtgc caaggagaac     4200

ttggtgaaat aaattatttt aatttttttt ttatccttta caaagccatg gattttattt     4260

ggttgatgtg tgctctgtac acaagccatt tcaataggat ggagctgtta attattttcc     4320

aaagagtaat agacatgcaa aagtttcaat aaaaactggg ccattaacaa ataaattaat     4380

aaactaataa gcattccctt ctaggttttt gccaaactgc ctatccaata acaaatttga     4440

gaatcgttgt aaaagctagt tatatttcag agaaatgatt ttcattattg aaactgttct     4500

ccctagcagg ccattttccc tttttcctgg gagtttagca agtttaggag agaatagtca     4560

tgaaaagaaa gggaagaaag gggagaaggg aagaggttaa aaagtaagtg ctcagaccta     4620

tgaacgtaat ccctttgcta caaatattta agagcagctc agcttggttg aaactgagtt     4680

ttgtcatctt ccatatttgc aggaaggtat tttctgactt gcaatgcagc tagatgtaaa     4740

attttatttt atcatcctag aaagccttga ctagaaaaat gaataaatat tgagggtttc     4800

ctgtccatat ctggcttgca tgtgccagaa agcagagaat agaaaatgta atctccaaca     4860

tccaagcatc gaaacccaag gggtaggcaa ttctatgtag gttttggaca tgaagtttgg     4920

tgcatcttgg tttatgctgg ctcaactgct attaaacctc tctggcttat agtctcttca     4980

ttctattaga caagcacgta tcgaacactt gcttcgcaca aggctcttta gttaacaatt     5040

tagcagctac tgtttgtgtt aaacacactt ttcaccaaat aggttctgag gcaaacgaga     5100

gcaatgacta tttaaagaaa ggctttccca gcatcactta cacatcccaa aactaaaaag     5160

atcaactctt ccaactgaga aaagactcct ggctttgaat ggaaacttac agcagagagt     5220

cacaggccac ggcaacaaca acgacaacaa caaacatttg gaatattatt ctcaactcac     5280

gttttaataa tacatcttat tatttttcta gtagagaaac tacaaatcag cctcttcaac     5340

atttatatac agtttaataa gcctcttgca agttacttgt tctctcacct gaggtatttt     5400

tttcctcccc accttgcccc tgttcctccc ttcctcttct ccctttgcaa gaggaaatat     5460

ttaacatatt tgggtccaac ttcaataatg taataattaa tacattaaaa gcatttaact     5520

tcctttctag aaaaatgcac aggctaaggc atagacaaaa caaagagaaa tgctgagaaa     5580

tttgccactg gagacaagca atctgaataa atatttgcca aaagttcttt ttatgtcata     5640

tagtgtcagg atttgaagga gctatttttt tttaatgttg caactagcaa ctcatcttcg     5700

gaagacacag ccaggagaat gaagtagaag tgaaaggttt ataaatccat ttgtaagcat     5760

ttatcccata tattttaaat tcaagaaaaa ttgtgtttat ctttagaatt ttgtattcaa     5820

tactttatgt actatgtgac tcatgcttct ggataaataa agcaccaaat atgtatctgt     5880

aaccacaatc acacatatta tattaaatat atatctatat aacagcc                   5927


<210>  50
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Cys Lys Gly Leu Ala Ala Leu Pro His Ser Cys Leu Glu Arg Ala 
1               5                   10                  15      


Lys Glu Ile Lys Ile Lys Leu Gly Ile Leu Leu Gln Lys Pro Asp Ser 
            20                  25                  30          


Val Gly Asp Leu Val Ile Pro Tyr Asn Glu Lys Pro Glu Lys Pro Ala 
        35                  40                  45              


Lys Thr Gln Lys Thr Ser Leu Asp Glu Ala Leu Gln Trp Arg Asp Ser 
    50                  55                  60                  


Leu Asp Lys Leu Leu Gln Asn Asn Tyr Gly Leu Ala Ser Phe Lys Ser 
65                  70                  75                  80  


Phe Leu Lys Ser Glu Phe Ser Glu Glu Asn Leu Glu Phe Trp Ile Ala 
                85                  90                  95      


Cys Glu Asp Tyr Lys Lys Ile Lys Ser Pro Ala Lys Met Ala Glu Lys 
            100                 105                 110         


Ala Lys Gln Ile Tyr Glu Glu Phe Ile Gln Thr Glu Ala Pro Lys Glu 
        115                 120                 125             


Val Asn Ile Asp His Phe Thr Lys Asp Ile Thr Met Lys Asn Leu Val 
    130                 135                 140                 


Glu Pro Ser Leu Ser Ser Phe Asp Met Ala Gln Lys Arg Ile His Ala 
145                 150                 155                 160 


Leu Met Glu Lys Asp Ser Leu Pro Arg Phe Val Arg Ser Glu Phe Tyr 
                165                 170                 175     


Gln Glu Leu Ile Lys 
            180     


<210>  51
<211>  4099
<212>  DNA
<213>  Homo sapiens

<400>  51
agccagccct tgccgtggcc ggagccgagc ggcgcatccg ggccggagaa gaggacgacg       60

acgaggtcct cgaagtggac ccgtttgcga agcgccaggg agaaggagga gcggacgcat      120

cgtagaaagg ggtggtggcg cccgaccccg cgccccggcc cgaagctctg agggcttccc      180

ggcccccact gcctgcggca tggcccgggg ctcggcgctc ccgcggcggc cgctgctgtg      240

catcccggcc gtctgggcgg ccgccgcgct tctgctctca gtgtcccgga cttcaggtga      300

agtggaggtt ctggatccga acgacccttt aggacccctt gatgggcagg acggcccgat      360

tccaactctg aaaggttact ttctgaattt tctggagcca gtaaacaata tcaccattgt      420

ccaaggccag acggcaattc tgcactgcaa ggtggcagga aacccacccc ctaacgtgcg      480

gtggctaaag aatgatgccc cggtggtgca ggagccgcgg cggatcatca tccggaagac      540

agaatatggt tcacgactgc gaatccagga cctggacacg acagacactg gctactacca      600

gtgcgtggcc accaacggga tgaagaccat taccgccact ggcgtcctgt ttgtgcggct      660

gggtccaacg cacagcccaa atcataactt tcaggatgat taccacgagg atgggttctg      720

ccagccttac cggggaattg cctgtgcacg cttcattggc aaccggacca tttatgtgga      780

ctcgcttcag atgcaggggg agattgaaaa ccgaatcaca gcggccttca ccatgatcgg      840

cacgtctacg cacctgtcgg accagtgctc acagttcgcc atcccatcct tctgccactt      900

cgtgtttcct ctgtgcgacg cgcgctcccg gacacccaag ccgcgtgagc tgtgccgcga      960

cgagtgcgag gtgctggaga gcgacctgtg ccgccaggag tacaccatcg cccgctccaa     1020

cccgctcatc ctcatgcggc ttcagctgcc caagtgtgag gcgctgccca tgcctgagag     1080

ccccgacgct gccaactgca tgcgcattgg catcccagcc gagaggctgg gccgctacca     1140

tcagtgctat aacggctcag gcatggatta cagaggaacg gcaagcacca ccaagtcagg     1200

ccaccagtgc cagccgtggg ccctgcagca cccccacagc caccacctgt ccagcacaga     1260

cttccctgag cttggagggg ggcacgccta ctgccggaac cccggaggcc agatggaggg     1320

cccctggtgc tttacgcaga ataaaaacgt acgcatggaa ctgtgtgacg taccctcgtg     1380

tagtccccga gacagcagca agatggggat tctgtacatc ttggtcccca gcatcgcaat     1440

tccactggtc atcgcttgcc ttttcttctt ggtttgcatg tgccggaata agcagaaggc     1500

atctgcgtcc acaccgcagc ggcgacagct gatggcctcg cccagccaag acatggaaat     1560

gcccctcatt aaccagcaca aacaggccaa actcaaagag atcagcctgt ctgcggtgag     1620

gttcatggag gagctgggag aggaccggtt tgggaaagtc tacaaaggtc acctgttcgg     1680

ccctgccccg ggggagcaga cccaggctgt ggccatcaaa acgctgaagg acaaagcgga     1740

ggggcccctg cgggaggagt tccggcatga ggctatgctg cgagcacggc tgcaacaccc     1800

caacgtcgtc tgcctgctgg gcgtggtgac caaggaccag cccctgagca tgatcttcag     1860

ctactgttcg cacggcgacc tccacgaatt cctggtcatg cgctcgccgc actcggacgt     1920

gggcagcacc gatgatgacc gcacggtgaa gtccgccctg gagccccccg acttcgtgca     1980

ccttgtggca cagatcgcgg cggggatgga gtacctatcc agccaccacg tggttcacaa     2040

ggacctggcc acccgcaatg tgctagtgta cgacaagctg aacgtgaaga tctcagactt     2100

gggcctcttc cgagaggtgt atgccgccga ttactacaag ctgctgggga actcgctgct     2160

gcctatccgc tggatggccc cagaggccat catgtacggc aagttctcca tcgactcaga     2220

catctggtcc tacggtgtgg tcctgtggga ggtcttcagc tacggcctgc agccctactg     2280

cgggtactcc aaccaggatg tggtggagat gatccggaac cggcaggtgc tgccttgccc     2340

cgatgactgt cccgcctggg tgtatgccct catgatcgag tgctggaacg agttccccag     2400

ccggcggccc cgcttcaagg acatccacag ccggctccga gcctggggca acctttccaa     2460

ctacaacagc tcggcgcaga cctcgggggc cagcaacacc acgcagacca gctccctgag     2520

caccagccca gtgagcaatg tgagcaacgc ccgctacgtg gggcccaagc agaaggcccc     2580

gcccttccca cagccccagt tcatccccat gaagggccag atcagaccca tggtgccccc     2640

gccgcagctc tacgtccccg tcaacggcta ccagccggtg ccggcctatg gggcctacct     2700

gcccaacttc tacccggtgc agatcccaat gcagatggcc ccgcagcagg tgcctcctca     2760

gatggtcccc aagcccagct cacaccacag tggcagtggc tccaccagca caggctacgt     2820

caccacggcc ccctccaaca catccatggc agacagggca gccctgctct cagagggcgc     2880

tgatgacaca cagaacgccc cagaagatgg ggcccagagc accgtgcagg aagcagagga     2940

ggaggaggaa ggctctgtcc cagagactga gctgctgggg gactgtgaca ctctgcaggt     3000

ggacgaggcc caagtccagc tggaagcttg agtggcacca gggcccgggg ttcggggata     3060

gaagccccgc cgagacccca cagggacctc agtcaccttt gagaagacac catactcagc     3120

aatcacaaga gcccgccggc cagtgggctt gtttgcagac tgggtgaggt ggagccctgc     3180

tcctctctgt cctctgacac agagagctgc cctgcctagg agcacccaag ccaggcaggg     3240

ggtctggcag cacggcgtcc tggggagcag gacacatggt catccccagg gctgtataca     3300

ttgattctgg tggtagactg gtagtgagca gcaaatgcct ttcaagaaaa taggtggcag     3360

cttcactcca tgtcatatat ggagtgaata tttcaaaacg ttgggaataa gggcctgcaa     3420

aaggcagcga ggaggcacct cgggtcttga ggttcctgac aaccgatctg gtctgttggt     3480

ttgaggatga aggggctcca tttctgctgc ctccctgctg agaatattct ccctttagca     3540

gccaaagatt cgctggaacg gaggctgccc tctgctgcct gttggggtcg gaagacaagg     3600

ggcttctgaa atgggagttc ctgagataca acaaaatgtg tgccttcaaa gaaactgaca     3660

gctttgtatt tggtgaaatg gttttaatta tactccatgt gtattttgcc cacttttttt     3720

gggaattcaa gggaaagtgt ttcttgggtt tggaatgttc agaggaagca gtattgtaca     3780

gaacacggta ttgttatttt tgttaagaat catgtacaga gcttaaatgt aatttatatg     3840

tttttaatat gccattttca ttgaagtatt ttggtcttaa gatgacttta gtaatttaac     3900

tgtttatgtt acccacgttg ggatccagtt ggtcttggtt tgcttctctc tgtaccacgt     3960

gcacatgagg tccattcatt ttacagcccc tgttacacac agacccacag gcagccgtct     4020

gtgccccgca cacattgttg gtcctatttg taaatcccac acccggtgta tccaataaag     4080

tgaaacaaag catgtgaaa                                                  4099


<210>  52
<211>  943
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Ala Arg Gly Ser Ala Leu Pro Arg Arg Pro Leu Leu Cys Ile Pro 
1               5                   10                  15      


Ala Val Trp Ala Ala Ala Ala Leu Leu Leu Ser Val Ser Arg Thr Ser 
            20                  25                  30          


Gly Glu Val Glu Val Leu Asp Pro Asn Asp Pro Leu Gly Pro Leu Asp 
        35                  40                  45              


Gly Gln Asp Gly Pro Ile Pro Thr Leu Lys Gly Tyr Phe Leu Asn Phe 
    50                  55                  60                  


Leu Glu Pro Val Asn Asn Ile Thr Ile Val Gln Gly Gln Thr Ala Ile 
65                  70                  75                  80  


Leu His Cys Lys Val Ala Gly Asn Pro Pro Pro Asn Val Arg Trp Leu 
                85                  90                  95      


Lys Asn Asp Ala Pro Val Val Gln Glu Pro Arg Arg Ile Ile Ile Arg 
            100                 105                 110         


Lys Thr Glu Tyr Gly Ser Arg Leu Arg Ile Gln Asp Leu Asp Thr Thr 
        115                 120                 125             


Asp Thr Gly Tyr Tyr Gln Cys Val Ala Thr Asn Gly Met Lys Thr Ile 
    130                 135                 140                 


Thr Ala Thr Gly Val Leu Phe Val Arg Leu Gly Pro Thr His Ser Pro 
145                 150                 155                 160 


Asn His Asn Phe Gln Asp Asp Tyr His Glu Asp Gly Phe Cys Gln Pro 
                165                 170                 175     


Tyr Arg Gly Ile Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Ile Tyr 
            180                 185                 190         


Val Asp Ser Leu Gln Met Gln Gly Glu Ile Glu Asn Arg Ile Thr Ala 
        195                 200                 205             


Ala Phe Thr Met Ile Gly Thr Ser Thr His Leu Ser Asp Gln Cys Ser 
    210                 215                 220                 


Gln Phe Ala Ile Pro Ser Phe Cys His Phe Val Phe Pro Leu Cys Asp 
225                 230                 235                 240 


Ala Arg Ser Arg Thr Pro Lys Pro Arg Glu Leu Cys Arg Asp Glu Cys 
                245                 250                 255     


Glu Val Leu Glu Ser Asp Leu Cys Arg Gln Glu Tyr Thr Ile Ala Arg 
            260                 265                 270         


Ser Asn Pro Leu Ile Leu Met Arg Leu Gln Leu Pro Lys Cys Glu Ala 
        275                 280                 285             


Leu Pro Met Pro Glu Ser Pro Asp Ala Ala Asn Cys Met Arg Ile Gly 
    290                 295                 300                 


Ile Pro Ala Glu Arg Leu Gly Arg Tyr His Gln Cys Tyr Asn Gly Ser 
305                 310                 315                 320 


Gly Met Asp Tyr Arg Gly Thr Ala Ser Thr Thr Lys Ser Gly His Gln 
                325                 330                 335     


Cys Gln Pro Trp Ala Leu Gln His Pro His Ser His His Leu Ser Ser 
            340                 345                 350         


Thr Asp Phe Pro Glu Leu Gly Gly Gly His Ala Tyr Cys Arg Asn Pro 
        355                 360                 365             


Gly Gly Gln Met Glu Gly Pro Trp Cys Phe Thr Gln Asn Lys Asn Val 
    370                 375                 380                 


Arg Met Glu Leu Cys Asp Val Pro Ser Cys Ser Pro Arg Asp Ser Ser 
385                 390                 395                 400 


Lys Met Gly Ile Leu Tyr Ile Leu Val Pro Ser Ile Ala Ile Pro Leu 
                405                 410                 415     


Val Ile Ala Cys Leu Phe Phe Leu Val Cys Met Cys Arg Asn Lys Gln 
            420                 425                 430         


Lys Ala Ser Ala Ser Thr Pro Gln Arg Arg Gln Leu Met Ala Ser Pro 
        435                 440                 445             


Ser Gln Asp Met Glu Met Pro Leu Ile Asn Gln His Lys Gln Ala Lys 
    450                 455                 460                 


Leu Lys Glu Ile Ser Leu Ser Ala Val Arg Phe Met Glu Glu Leu Gly 
465                 470                 475                 480 


Glu Asp Arg Phe Gly Lys Val Tyr Lys Gly His Leu Phe Gly Pro Ala 
                485                 490                 495     


Pro Gly Glu Gln Thr Gln Ala Val Ala Ile Lys Thr Leu Lys Asp Lys 
            500                 505                 510         


Ala Glu Gly Pro Leu Arg Glu Glu Phe Arg His Glu Ala Met Leu Arg 
        515                 520                 525             


Ala Arg Leu Gln His Pro Asn Val Val Cys Leu Leu Gly Val Val Thr 
    530                 535                 540                 


Lys Asp Gln Pro Leu Ser Met Ile Phe Ser Tyr Cys Ser His Gly Asp 
545                 550                 555                 560 


Leu His Glu Phe Leu Val Met Arg Ser Pro His Ser Asp Val Gly Ser 
                565                 570                 575     


Thr Asp Asp Asp Arg Thr Val Lys Ser Ala Leu Glu Pro Pro Asp Phe 
            580                 585                 590         


Val His Leu Val Ala Gln Ile Ala Ala Gly Met Glu Tyr Leu Ser Ser 
        595                 600                 605             


His His Val Val His Lys Asp Leu Ala Thr Arg Asn Val Leu Val Tyr 
    610                 615                 620                 


Asp Lys Leu Asn Val Lys Ile Ser Asp Leu Gly Leu Phe Arg Glu Val 
625                 630                 635                 640 


Tyr Ala Ala Asp Tyr Tyr Lys Leu Leu Gly Asn Ser Leu Leu Pro Ile 
                645                 650                 655     


Arg Trp Met Ala Pro Glu Ala Ile Met Tyr Gly Lys Phe Ser Ile Asp 
            660                 665                 670         


Ser Asp Ile Trp Ser Tyr Gly Val Val Leu Trp Glu Val Phe Ser Tyr 
        675                 680                 685             


Gly Leu Gln Pro Tyr Cys Gly Tyr Ser Asn Gln Asp Val Val Glu Met 
    690                 695                 700                 


Ile Arg Asn Arg Gln Val Leu Pro Cys Pro Asp Asp Cys Pro Ala Trp 
705                 710                 715                 720 


Val Tyr Ala Leu Met Ile Glu Cys Trp Asn Glu Phe Pro Ser Arg Arg 
                725                 730                 735     


Pro Arg Phe Lys Asp Ile His Ser Arg Leu Arg Ala Trp Gly Asn Leu 
            740                 745                 750         


Ser Asn Tyr Asn Ser Ser Ala Gln Thr Ser Gly Ala Ser Asn Thr Thr 
        755                 760                 765             


Gln Thr Ser Ser Leu Ser Thr Ser Pro Val Ser Asn Val Ser Asn Ala 
    770                 775                 780                 


Arg Tyr Val Gly Pro Lys Gln Lys Ala Pro Pro Phe Pro Gln Pro Gln 
785                 790                 795                 800 


Phe Ile Pro Met Lys Gly Gln Ile Arg Pro Met Val Pro Pro Pro Gln 
                805                 810                 815     


Leu Tyr Val Pro Val Asn Gly Tyr Gln Pro Val Pro Ala Tyr Gly Ala 
            820                 825                 830         


Tyr Leu Pro Asn Phe Tyr Pro Val Gln Ile Pro Met Gln Met Ala Pro 
        835                 840                 845             


Gln Gln Val Pro Pro Gln Met Val Pro Lys Pro Ser Ser His His Ser 
    850                 855                 860                 


Gly Ser Gly Ser Thr Ser Thr Gly Tyr Val Thr Thr Ala Pro Ser Asn 
865                 870                 875                 880 


Thr Ser Met Ala Asp Arg Ala Ala Leu Leu Ser Glu Gly Ala Asp Asp 
                885                 890                 895     


Thr Gln Asn Ala Pro Glu Asp Gly Ala Gln Ser Thr Val Gln Glu Ala 
            900                 905                 910         


Glu Glu Glu Glu Glu Gly Ser Val Pro Glu Thr Glu Leu Leu Gly Asp 
        915                 920                 925             


Cys Asp Thr Leu Gln Val Asp Glu Ala Gln Val Gln Leu Glu Ala 
    930                 935                 940             


<210>  53
<211>  1629
<212>  DNA
<213>  Homo sapiens

<400>  53
attcatgaaa atccactact ccagacagac ggctttggaa tccaccagct acatccagct       60

ccctgaggca gagttgagaa tggagagaat gttacctctc ctggctctgg ggctcttggc      120

ggctgggttc tgccctgctg tcctctgcca ccctaacagc ccacttgacg aggagaatct      180

gacccaggag aaccaagacc gagggacaca cgtggacctc ggattagcct ccgccaacgt      240

ggacttcgct ttcagcctgt acaagcagtt agtcctgaag gcccctgata agaatgtcat      300

cttctcccca ctgagcatct ccaccgcctt ggccttcctg tctctggggg cccataatac      360

caccctgaca gagattctca aaggcctcaa gttcaacctc acggagactt ctgaggcaga      420

aattcaccag agcttccagc acctcctgcg caccctcaat cagtccagcg atgagctgca      480

gctgagtatg ggaaatgcca tgtttgtcaa agagcaactc agtctgctgg acaggttcac      540

ggaggatgcc aagaggctgt atggctccga ggcctttgcc actgactttc aggactcagc      600

tgcagctaag aagctcatca acgactacgt gaagaatgga actaggggga aaatcacaga      660

tctgatcaag gaccttgact cgcagacaat gatggtcctg gtgaattaca tcttctttaa      720

agccaaatgg gagatgccct ttgaccccca agatactcat cagtcaaggt tctacttgag      780

caagaaaaag tgggtaatgg tgcccatgat gagtttgcat cacctgacta taccttactt      840

ccgggacgag gagctgtcct gcaccgtggt ggagctgaag tacacaggca atgccagcgc      900

actcttcatc ctccctgatc aagacaagat ggaggaagtg gaagccatgc tgctcccaga      960

gaccctgaag cggtggagag actctctgga gttcagagag ataggtgagc tctacctgcc     1020

aaagttttcc atctcgaggg actataacct gaacgacata cttctccagc tgggcattga     1080

ggaagccttc accagcaagg ctgacctgtc agggatcaca ggggccagga acctagcagt     1140

ctcccaggtg gtccataagg ctgtgcttga tgtatttgag gagggcacag aagcatctgc     1200

tgccacagca gtcaaaatca ccctcctttc tgcattagtg gagacaagga ccattgtgcg     1260

tttcaacagg cccttcctga tgatcattgt ccctacagac acccagaaca tcttcttcat     1320

gagcaaagtc accaatccca agcaagccta gagcttgcca tcaagcagtg gggctctcag     1380

taaggaactt ggaatgcaag ctggatgcct gggtctctgg gcacagcctg gcccctgtgc     1440

accgagtggc catggcatgt gtggccctgt ctgcttatcc ttggaaggtg acagcgattc     1500

cctgtgtagc tctcacatgc acaggggccc atggactctt cagtctggag ggtcctgggc     1560

ctcctgacag caataaataa tttcgttgga aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1620

aaaaaaaaa                                                             1629


<210>  54
<211>  423
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Glu Arg Met Leu Pro Leu Leu Ala Leu Gly Leu Leu Ala Ala Gly 
1               5                   10                  15      


Phe Cys Pro Ala Val Leu Cys His Pro Asn Ser Pro Leu Asp Glu Glu 
            20                  25                  30          


Asn Leu Thr Gln Glu Asn Gln Asp Arg Gly Thr His Val Asp Leu Gly 
        35                  40                  45              


Leu Ala Ser Ala Asn Val Asp Phe Ala Phe Ser Leu Tyr Lys Gln Leu 
    50                  55                  60                  


Val Leu Lys Ala Pro Asp Lys Asn Val Ile Phe Ser Pro Leu Ser Ile 
65                  70                  75                  80  


Ser Thr Ala Leu Ala Phe Leu Ser Leu Gly Ala His Asn Thr Thr Leu 
                85                  90                  95      


Thr Glu Ile Leu Lys Gly Leu Lys Phe Asn Leu Thr Glu Thr Ser Glu 
            100                 105                 110         


Ala Glu Ile His Gln Ser Phe Gln His Leu Leu Arg Thr Leu Asn Gln 
        115                 120                 125             


Ser Ser Asp Glu Leu Gln Leu Ser Met Gly Asn Ala Met Phe Val Lys 
    130                 135                 140                 


Glu Gln Leu Ser Leu Leu Asp Arg Phe Thr Glu Asp Ala Lys Arg Leu 
145                 150                 155                 160 


Tyr Gly Ser Glu Ala Phe Ala Thr Asp Phe Gln Asp Ser Ala Ala Ala 
                165                 170                 175     


Lys Lys Leu Ile Asn Asp Tyr Val Lys Asn Gly Thr Arg Gly Lys Ile 
            180                 185                 190         


Thr Asp Leu Ile Lys Asp Leu Asp Ser Gln Thr Met Met Val Leu Val 
        195                 200                 205             


Asn Tyr Ile Phe Phe Lys Ala Lys Trp Glu Met Pro Phe Asp Pro Gln 
    210                 215                 220                 


Asp Thr His Gln Ser Arg Phe Tyr Leu Ser Lys Lys Lys Trp Val Met 
225                 230                 235                 240 


Val Pro Met Met Ser Leu His His Leu Thr Ile Pro Tyr Phe Arg Asp 
                245                 250                 255     


Glu Glu Leu Ser Cys Thr Val Val Glu Leu Lys Tyr Thr Gly Asn Ala 
            260                 265                 270         


Ser Ala Leu Phe Ile Leu Pro Asp Gln Asp Lys Met Glu Glu Val Glu 
        275                 280                 285             


Ala Met Leu Leu Pro Glu Thr Leu Lys Arg Trp Arg Asp Ser Leu Glu 
    290                 295                 300                 


Phe Arg Glu Ile Gly Glu Leu Tyr Leu Pro Lys Phe Ser Ile Ser Arg 
305                 310                 315                 320 


Asp Tyr Asn Leu Asn Asp Ile Leu Leu Gln Leu Gly Ile Glu Glu Ala 
                325                 330                 335     


Phe Thr Ser Lys Ala Asp Leu Ser Gly Ile Thr Gly Ala Arg Asn Leu 
            340                 345                 350         


Ala Val Ser Gln Val Val His Lys Ala Val Leu Asp Val Phe Glu Glu 
        355                 360                 365             


Gly Thr Glu Ala Ser Ala Ala Thr Ala Val Lys Ile Thr Leu Leu Ser 
    370                 375                 380                 


Ala Leu Val Glu Thr Arg Thr Ile Val Arg Phe Asn Arg Pro Phe Leu 
385                 390                 395                 400 


Met Ile Ile Val Pro Thr Asp Thr Gln Asn Ile Phe Phe Met Ser Lys 
                405                 410                 415     


Val Thr Asn Pro Lys Gln Ala 
            420             


<210>  55
<211>  4234
<212>  DNA
<213>  Homo sapiens

<400>  55
gcggagcgcg aggaggtgga gccgcgggct gcgggctccg gcgcctgcgt ccgcccggcc       60

agcccggctc tgcgctgcga gaggccggac ggcagtcgcg gctgcgctcg ggagagagcg      120

cgggggacat ggggcgcggc ggcccgcctg ggcctcgcag gctccggagc cccgagggct      180

ccccgctagg ccccctcagt ggcccctcct tctcacctgg gtctcgggtc ccctagtgag      240

cgagagcgtc cccagccgcc tacctggcca tggccaacgg agtgatcccg ccgcccgggg      300

gcgcctcccc cctaccccag gtccgggtgc ccttggagga gccccctcta agtccagacg      360

tggaggagga ggacgatgac ttgggcaaga ccttggctgt gagcaggttt ggggacctca      420

tcagcaagcc cccggcctgg gaccccgaga agcccagccg cagctacagc gagcgggact      480

ttgagtttca ccggcacaca tcccaccaca cccaccaccc gctctcagcg cgcctgcctc      540

caccccacaa gctgcggcgg ctgcccccca cctctgcccg gcacaccagg agaaagagga      600

agaaggagaa aacctctgct cctccctccg aggggacccc tcccatccag gaggaggggg      660

gagctggagt ggatgaggaa gaggaggaag aggaggaaga ggaaggagaa tctgaggcag      720

aacctgtgga gccccccccc tcagggaccc cacagaaggc aaagttctcc attggaagtg      780

acgaggatga cagtccaggc ctccctggga gggctgctgt caccaagccc ctgccctcgg      840

tgggcccaca cactgacaag agcccccagc actccagcag ctcccccagc ccccgggccc      900

gggcctcccg actcgctggg gagaaaagcc ggccctggag cccatcggcc agttatgacc      960

tgcgggagcg actgtgccca ggcagtgccc tgggcaaccc aggtggtcca gagcagcagg     1020

tgcccacaga tgaggcggag gcccagatgc tgggttctgc agacctggac gacatgaaga     1080

gtcaccgact ggaggacaac cctggtgtgc ggcgacactt agtgaaaaag ccctcccgga     1140

cgcagggcgg gaggggcagt cccagcggcc tggcccccat ccttcgcagg aagaagaaga     1200

agaaaaagct ggaccggagg cctcatgagg tgttcgtgga gctgaacgag ctgatgctgg     1260

accgcagcca ggagccccac tggcgggaga cggcccgctg gatcaagttt gaggaggacg     1320

tggaggagga gacggagcgc tgggggaagc cccatgttgc ctcgctctcc ttccgtagcc     1380

ttctggagct caggaggacc atcgcccatg gagctgccct cctggacctg gagcaaacca     1440

ccctgccagg cattgcacac ctcgtggtgg agaccatgat tgtgtctgac cagatccggc     1500

cggaggacag ggccagcgtc ctacgtaccc tgctactgaa gcacagccat cccaacgatg     1560

acaaggacag tggcttcttt ccccgaaacc catcgagctc cagcatgaac tcggttctgg     1620

ggaatcatca cccaactccc agccatggcc ctgatggggc ggtgcctacc atggctgatg     1680

acctggggga gccagcccca ctctggccac atgaccctga cgccaaggag aagcccctcc     1740

acatgcctgg gggagatggt caccggggga aaagcctgaa gctgctggag aagatccctg     1800

aagatgctga ggccacggtt gtgcttgtgg gttgtgtgcc tttcttggag cagcctgcag     1860

cagccttcgt gcgtctgaat gaggctgtac tcctggagtc tgtgcttgag gtccctgtcc     1920

cggtccgctt cctcttcgtg atgctggggc ccagccacac cagcactgac tatcacgagc     1980

ttgggcgctc cattgccacc cttatgtctg acaagctgtt tcatgaggct gcctaccagg     2040

cagatgaccg gcaagacctc ctaagtgcca tcagcgagtt cctggatggc agcattgtga     2100

tccccccgtc cgaggtggag ggccgtgacc tgctgcgctc cgtggctgct ttccagcgag     2160

agctgcttag gaagcggcga gagcgtgaac agaccaaagt cgagatgacc acacggggtg     2220

gctacacggc ccctgggaaa gaactgtctt tggagttggg gggctctgag gcgacccctg     2280

aagatgaccc cttgctgcgg acgggctcgg tatttggggg gcttgtgcgg gatgtgaggc     2340

gccggtaccc gcactacccc agtgacctgc gagatgcgct gcactcccag tgtgtggccg     2400

ctgtgctctt catctacttc gcagccctca gccctgccat caccttcggg gggctgctgg     2460

gagagaagac cgaggggctg atgggcgtgt ccgagctgat cgtgtccacc gctgtgctcg     2520

gcgtcctctt ctctctgctg ggagctcagc cgctgcttgt ggttggcttc tctgggccgc     2580

tgcttgtgtt tgaggaagcc ttcttcaagt tctgccgagc ccaggacctg gagtacctca     2640

ctggccgggt gtgggttggt ctctggctgg tggtcttcgt ccttgccctg gtggccgccg     2700

aaggcagctt cctggtccgc tacatctcgc ctttcaccca ggagatcttt gcctttctca     2760

tctcactcat tttcatctac gagaccttct acaagctcta caaggtgttc acagagcacc     2820

cactgctgcc gttctacccc cctgaggggg ccctggaggg gtccctggat gctggtctgg     2880

agccaaatgg cagtgccctg ccccccaccg agggcccccc cagcccgagg aaccagccca     2940

atacggcact gctctcactc atcctcatgc tcgggacctt cttcatagcc ttcttcctgc     3000

gcaagttcag gaacagccgc ttcctggggg gcaaggctcg tcgcatcatc ggggactttg     3060

gcatccccat ctccatcctg gtgatggtcc tggtggatta ctccatcaca gacacctaca     3120

cgcagaagct gacagtgcct acagggctct cagtgacctc tcccgataag cgctcgtggt     3180

tcatcccacc cctgggcagt gcccgtcctt tcccgccgtg gatgatggtg gcagccgctg     3240

ttcccgccct cctcgtcctc atcctgatct tcatggagac acagatcacg gcgcttatcg     3300

tcagccagaa ggcgcggagg ctgctcaagg gctccggttt ccacctggac ctgctcctca     3360

ttggctccct gggggggctc tgtgggctgt ttgggttgcc ctggctcacg gctgccacgg     3420

tccgctccgt cacccatgtc aatgcgttga cagtgatgcg tactgccatc gcgcctggtg     3480

acaagcccca gatccaggag gtgcgggagc agcgggtcac tggtgtgctc atcgccagcc     3540

tcgtgggcct gtccatcgtc atgggggctg tgctgcgtcg gatcccattg gctgtgctct     3600

ttgggatctt cctgtacatg ggggtcacgt ccctgtctgg tatccagctg tcccagcgtt     3660

tgttgctcat cctcatgccg gcaaaacacc atcctgagca gccctatgtg accaaggtga     3720

agacgtggcg gatgcatctg ttcacctgca tccagctggg ctgcatcgca ctgctctggg     3780

tggtcaagtc cacggcggcc tcactcgcct ttcccttcct gctgctgctc acggtgcctc     3840

tgaggcattg ccttctgccc cggctcttcc aggacaggga gctgcaggcg ctggactcgg     3900

aagatgctga accaaacttc gatgaggatg gccaggatga gtacaatgag ctgcacatgc     3960

cagtgtgacc cttgaagaca gtgcccctca gagaccccaa gaccttaggg attgacacct     4020

gggcctcagg cagagcccag ccctgggctg gggggctcct caggacccag agatgtgcct     4080

ggaaccactc ctgatgccat ggctagagtg gcccccctga cttctgcccg gggtgttgac     4140

ctcgcctcac ctttcacaga ccagaccggc acaggctttg agctcattat aaccacactc     4200

cttgtctcgt gtctgcctca aaaaaaaaaa aaaa                                 4234


<210>  56
<211>  1232
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Ala Asn Gly Val Ile Pro Pro Pro Gly Gly Ala Ser Pro Leu Pro 
1               5                   10                  15      


Gln Val Arg Val Pro Leu Glu Glu Pro Pro Leu Ser Pro Asp Val Glu 
            20                  25                  30          


Glu Glu Asp Asp Asp Leu Gly Lys Thr Leu Ala Val Ser Arg Phe Gly 
        35                  40                  45              


Asp Leu Ile Ser Lys Pro Pro Ala Trp Asp Pro Glu Lys Pro Ser Arg 
    50                  55                  60                  


Ser Tyr Ser Glu Arg Asp Phe Glu Phe His Arg His Thr Ser His His 
65                  70                  75                  80  


Thr His His Pro Leu Ser Ala Arg Leu Pro Pro Pro His Lys Leu Arg 
                85                  90                  95      


Arg Leu Pro Pro Thr Ser Ala Arg His Thr Arg Arg Lys Arg Lys Lys 
            100                 105                 110         


Glu Lys Thr Ser Ala Pro Pro Ser Glu Gly Thr Pro Pro Ile Gln Glu 
        115                 120                 125             


Glu Gly Gly Ala Gly Val Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu 
    130                 135                 140                 


Glu Gly Glu Ser Glu Ala Glu Pro Val Glu Pro Pro Pro Ser Gly Thr 
145                 150                 155                 160 


Pro Gln Lys Ala Lys Phe Ser Ile Gly Ser Asp Glu Asp Asp Ser Pro 
                165                 170                 175     


Gly Leu Pro Gly Arg Ala Ala Val Thr Lys Pro Leu Pro Ser Val Gly 
            180                 185                 190         


Pro His Thr Asp Lys Ser Pro Gln His Ser Ser Ser Ser Pro Ser Pro 
        195                 200                 205             


Arg Ala Arg Ala Ser Arg Leu Ala Gly Glu Lys Ser Arg Pro Trp Ser 
    210                 215                 220                 


Pro Ser Ala Ser Tyr Asp Leu Arg Glu Arg Leu Cys Pro Gly Ser Ala 
225                 230                 235                 240 


Leu Gly Asn Pro Gly Gly Pro Glu Gln Gln Val Pro Thr Asp Glu Ala 
                245                 250                 255     


Glu Ala Gln Met Leu Gly Ser Ala Asp Leu Asp Asp Met Lys Ser His 
            260                 265                 270         


Arg Leu Glu Asp Asn Pro Gly Val Arg Arg His Leu Val Lys Lys Pro 
        275                 280                 285             


Ser Arg Thr Gln Gly Gly Arg Gly Ser Pro Ser Gly Leu Ala Pro Ile 
    290                 295                 300                 


Leu Arg Arg Lys Lys Lys Lys Lys Lys Leu Asp Arg Arg Pro His Glu 
305                 310                 315                 320 


Val Phe Val Glu Leu Asn Glu Leu Met Leu Asp Arg Ser Gln Glu Pro 
                325                 330                 335     


His Trp Arg Glu Thr Ala Arg Trp Ile Lys Phe Glu Glu Asp Val Glu 
            340                 345                 350         


Glu Glu Thr Glu Arg Trp Gly Lys Pro His Val Ala Ser Leu Ser Phe 
        355                 360                 365             


Arg Ser Leu Leu Glu Leu Arg Arg Thr Ile Ala His Gly Ala Ala Leu 
    370                 375                 380                 


Leu Asp Leu Glu Gln Thr Thr Leu Pro Gly Ile Ala His Leu Val Val 
385                 390                 395                 400 


Glu Thr Met Ile Val Ser Asp Gln Ile Arg Pro Glu Asp Arg Ala Ser 
                405                 410                 415     


Val Leu Arg Thr Leu Leu Leu Lys His Ser His Pro Asn Asp Asp Lys 
            420                 425                 430         


Asp Ser Gly Phe Phe Pro Arg Asn Pro Ser Ser Ser Ser Met Asn Ser 
        435                 440                 445             


Val Leu Gly Asn His His Pro Thr Pro Ser His Gly Pro Asp Gly Ala 
    450                 455                 460                 


Val Pro Thr Met Ala Asp Asp Leu Gly Glu Pro Ala Pro Leu Trp Pro 
465                 470                 475                 480 


His Asp Pro Asp Ala Lys Glu Lys Pro Leu His Met Pro Gly Gly Asp 
                485                 490                 495     


Gly His Arg Gly Lys Ser Leu Lys Leu Leu Glu Lys Ile Pro Glu Asp 
            500                 505                 510         


Ala Glu Ala Thr Val Val Leu Val Gly Cys Val Pro Phe Leu Glu Gln 
        515                 520                 525             


Pro Ala Ala Ala Phe Val Arg Leu Asn Glu Ala Val Leu Leu Glu Ser 
    530                 535                 540                 


Val Leu Glu Val Pro Val Pro Val Arg Phe Leu Phe Val Met Leu Gly 
545                 550                 555                 560 


Pro Ser His Thr Ser Thr Asp Tyr His Glu Leu Gly Arg Ser Ile Ala 
                565                 570                 575     


Thr Leu Met Ser Asp Lys Leu Phe His Glu Ala Ala Tyr Gln Ala Asp 
            580                 585                 590         


Asp Arg Gln Asp Leu Leu Ser Ala Ile Ser Glu Phe Leu Asp Gly Ser 
        595                 600                 605             


Ile Val Ile Pro Pro Ser Glu Val Glu Gly Arg Asp Leu Leu Arg Ser 
    610                 615                 620                 


Val Ala Ala Phe Gln Arg Glu Leu Leu Arg Lys Arg Arg Glu Arg Glu 
625                 630                 635                 640 


Gln Thr Lys Val Glu Met Thr Thr Arg Gly Gly Tyr Thr Ala Pro Gly 
                645                 650                 655     


Lys Glu Leu Ser Leu Glu Leu Gly Gly Ser Glu Ala Thr Pro Glu Asp 
            660                 665                 670         


Asp Pro Leu Leu Arg Thr Gly Ser Val Phe Gly Gly Leu Val Arg Asp 
        675                 680                 685             


Val Arg Arg Arg Tyr Pro His Tyr Pro Ser Asp Leu Arg Asp Ala Leu 
    690                 695                 700                 


His Ser Gln Cys Val Ala Ala Val Leu Phe Ile Tyr Phe Ala Ala Leu 
705                 710                 715                 720 


Ser Pro Ala Ile Thr Phe Gly Gly Leu Leu Gly Glu Lys Thr Glu Gly 
                725                 730                 735     


Leu Met Gly Val Ser Glu Leu Ile Val Ser Thr Ala Val Leu Gly Val 
            740                 745                 750         


Leu Phe Ser Leu Leu Gly Ala Gln Pro Leu Leu Val Val Gly Phe Ser 
        755                 760                 765             


Gly Pro Leu Leu Val Phe Glu Glu Ala Phe Phe Lys Phe Cys Arg Ala 
    770                 775                 780                 


Gln Asp Leu Glu Tyr Leu Thr Gly Arg Val Trp Val Gly Leu Trp Leu 
785                 790                 795                 800 


Val Val Phe Val Leu Ala Leu Val Ala Ala Glu Gly Ser Phe Leu Val 
                805                 810                 815     


Arg Tyr Ile Ser Pro Phe Thr Gln Glu Ile Phe Ala Phe Leu Ile Ser 
            820                 825                 830         


Leu Ile Phe Ile Tyr Glu Thr Phe Tyr Lys Leu Tyr Lys Val Phe Thr 
        835                 840                 845             


Glu His Pro Leu Leu Pro Phe Tyr Pro Pro Glu Gly Ala Leu Glu Gly 
    850                 855                 860                 


Ser Leu Asp Ala Gly Leu Glu Pro Asn Gly Ser Ala Leu Pro Pro Thr 
865                 870                 875                 880 


Glu Gly Pro Pro Ser Pro Arg Asn Gln Pro Asn Thr Ala Leu Leu Ser 
                885                 890                 895     


Leu Ile Leu Met Leu Gly Thr Phe Phe Ile Ala Phe Phe Leu Arg Lys 
            900                 905                 910         


Phe Arg Asn Ser Arg Phe Leu Gly Gly Lys Ala Arg Arg Ile Ile Gly 
        915                 920                 925             


Asp Phe Gly Ile Pro Ile Ser Ile Leu Val Met Val Leu Val Asp Tyr 
    930                 935                 940                 


Ser Ile Thr Asp Thr Tyr Thr Gln Lys Leu Thr Val Pro Thr Gly Leu 
945                 950                 955                 960 


Ser Val Thr Ser Pro Asp Lys Arg Ser Trp Phe Ile Pro Pro Leu Gly 
                965                 970                 975     


Ser Ala Arg Pro Phe Pro Pro Trp Met Met Val Ala Ala Ala Val Pro 
            980                 985                 990         


Ala Leu Leu Val Leu Ile Leu Ile  Phe Met Glu Thr Gln  Ile Thr Ala 
        995                 1000                 1005             


Leu Ile  Val Ser Gln Lys Ala  Arg Arg Leu Leu Lys  Gly Ser Gly 
    1010                 1015                 1020             


Phe His  Leu Asp Leu Leu Leu  Ile Gly Ser Leu Gly  Gly Leu Cys 
    1025                 1030                 1035             


Gly Leu  Phe Gly Leu Pro Trp  Leu Thr Ala Ala Thr  Val Arg Ser 
    1040                 1045                 1050             


Val Thr  His Val Asn Ala Leu  Thr Val Met Arg Thr  Ala Ile Ala 
    1055                 1060                 1065             


Pro Gly  Asp Lys Pro Gln Ile  Gln Glu Val Arg Glu  Gln Arg Val 
    1070                 1075                 1080             


Thr Gly  Val Leu Ile Ala Ser  Leu Val Gly Leu Ser  Ile Val Met 
    1085                 1090                 1095             


Gly Ala  Val Leu Arg Arg Ile  Pro Leu Ala Val Leu  Phe Gly Ile 
    1100                 1105                 1110             


Phe Leu  Tyr Met Gly Val Thr  Ser Leu Ser Gly Ile  Gln Leu Ser 
    1115                 1120                 1125             


Gln Arg  Leu Leu Leu Ile Leu  Met Pro Ala Lys His  His Pro Glu 
    1130                 1135                 1140             


Gln Pro  Tyr Val Thr Lys Val  Lys Thr Trp Arg Met  His Leu Phe 
    1145                 1150                 1155             


Thr Cys  Ile Gln Leu Gly Cys  Ile Ala Leu Leu Trp  Val Val Lys 
    1160                 1165                 1170             


Ser Thr  Ala Ala Ser Leu Ala  Phe Pro Phe Leu Leu  Leu Leu Thr 
    1175                 1180                 1185             


Val Pro  Leu Arg His Cys Leu  Leu Pro Arg Leu Phe  Gln Asp Arg 
    1190                 1195                 1200             


Glu Leu  Gln Ala Leu Asp Ser  Glu Asp Ala Glu Pro  Asn Phe Asp 
    1205                 1210                 1215             


Glu Asp  Gly Gln Asp Glu Tyr  Asn Glu Leu His Met  Pro Val 
    1220                 1225                 1230         


<210>  57
<211>  7693
<212>  DNA
<213>  Homo sapiens

<400>  57
gcggcggcgg ccgcggtggc agcgaaggcg gcggcggcgg cggcagtggc agtggccgct       60

gcagccccac actccgccgc caaactggag gagcgacgga agccagaccc caggaggatg      120

gaggatgaag ctgtcctgga cagaggggct tccttcctca agcatgtgtg tgatgaagaa      180

gaagtagaag gccaccatac catttacatc ggagtccatg tgccgaagag ttacaggaga      240

aggagacgtc acaagagaaa gacagggcac aaagaaaaga aggaaaagga gagaatctct      300

gagaactact ctgacaaatc agatattgaa aatgctgatg aatccagcag cagcatccta      360

aaacctctca tctctcctgc tgcagaacgc atccgattca tcttgggaga ggaggatgac      420

agcccagctc cccctcagct cttcacggaa ctggatgagc tgctggccgt ggatgggcag      480

gagatggagt ggaaggaaac agccaggtgg atcaagtttg aagaaaaagt ggaacagggt      540

ggggaaagat ggagcaagcc ccatgtggcc acattgtccc ttcatagttt atttgagctg      600

aggacatgta tggagaaagg atccatcatg cttgatcggg aggcttcttc tctcccacag      660

ttggtggaga tgattgttga ccatcagatt gagacaggcc tattgaaacc tgaacttaag      720

gataaggtga cctatacttt gctccggaag caccggcatc aaaccaagaa atccaacctt      780

cggtccctgg ctgacattgg gaagacagtc tccagtgcaa gtaggatgtt taccaaccct      840

gataatggta gcccagccat gacccatagg aatctgactt cctccagtct gaatgacatt      900

tctgataaac cggagaagga ccagctgaag aataagttca tgaaaaaatt gccacgtgat      960

gcagaagctt ccaacgtgct tgttggggag gttgactttt tggatactcc tttcattgcc     1020

tttgttaggc tacagcaggc tgtcatgctg ggtgccctga ctgaagttcc tgtgcccaca     1080

aggttcttgt tcattctctt aggtcctaag gggaaagcca agtcctacca cgagattggc     1140

agagccattg ccaccctgat gtctgatgag gtgttccatg acattgctta taaagcaaaa     1200

gacaggcacg acctgattgc tggtattgat gagttcctag atgaagtcat cgtccttcca     1260

cctggggaat gggatccagc aattaggata gagcctccta agagtcttcc atcctctgac     1320

aaaagaaaga atatgtactc aggtggagag aatgttcaga tgaatgggga tacgccccat     1380

gatggaggtc acggaggagg aggacatggg gattgtgaag aattgcagcg aactggacgg     1440

ttctgtggtg gactaattaa agacataaag aggaaagcgc cattttttgc cagtgatttt     1500

tatgatgctt taaatattca agctctttcg gcaattctct tcatttatct ggcaactgta     1560

actaatgcta tcacttttgg aggactgctt ggggatgcca ctgacaacat gcagggcgtg     1620

ttggagagtt tcctgggcac tgctgtctct ggagccatct tttgcctttt tgctggtcaa     1680

ccactcacta ttctgagcag caccggacct gtcctagttt ttgagaggct tctatttaat     1740

ttcagcaagg acaataattt tgactatttg gagtttcgcc tttggattgg cctgtggtcc     1800

gccttcctat gtctcatttt ggtagccact gatgccagct tcttggttca atacttcaca     1860

cgtttcacgg aggagggctt ttcctctctg attagcttca tctttatcta tgatgctttc     1920

aagaagatga tcaagcttgc agattactac cccatcaact ccaacttcaa agtgggctac     1980

aacactctct tttcctgtac ctgtgtgcca cctgacccag ctaatatctc aatatctaat     2040

gacaccacac tggccccaga gtatttgcca actatgtctt ctactgacat gtaccataat     2100

actacctttg actgggcatt tttgtcgaag aaggagtgtt caaaatacgg aggaaacctc     2160

gtcgggaaca actgtaattt tgttcctgat atcacactca tgtcttttat cctcttcttg     2220

ggaacctaca cctcttccat ggctctgaaa aaattcaaaa ctagtcctta ttttccaacc     2280

acagcaagaa aactgatcag tgattttgcc attatcttgt ccattctcat cttttgtgta     2340

atagatgccc tagtaggcgt ggacacccca aaactaattg tgccaagtga gttcaagcca     2400

acaagtccaa accgaggttg gttcgttcca ccgtttggag aaaacccctg gtgggtgtgc     2460

cttgctgctg ctatcccggc tttgttggtc actatactga ttttcatgga ccaacaaatt     2520

acagctgtga ttgtaaacag gaaagaacat aaactcaaga aaggagcagg gtatcacttg     2580

gatctctttt gggtggccat cctcatggtt atatgctccc tcatggctct tccgtggtat     2640

gtagctgcta cggtcatctc cattgctcac atcgacagtt tgaagatgga gacagagact     2700

tctgcacctg gagaacaacc aaagtttcta ggagtgaggg aacaaagagt cactggaacc     2760

cttgtgttta ttctgactgg tctgtcagtc tttatggctc ccatcttgaa gtttataccc     2820

atgcctgtac tctatggtgt gttcctgtat atgggagtag catcccttaa tggtgtgcag     2880

ttcatggatc gtctgaagct gcttctgatg cctctgaagc atcagcctga cttcatctac     2940

ctgcgtcatg ttcctctgcg cagagtccac ctgttcactt tcctgcaggt gttgtgtctg     3000

gccctgcttt ggatcctcaa gtcaacggtg gctgctatca tttttccagt aatgatcttg     3060

gcacttgtag ctgtcagaaa aggcatggac tacctcttct cccagcatga cctcagcttc     3120

ctggatgatg tcattccaga aaaggacaag aaaaagaagg aggatgagaa gaaaaagaaa     3180

aagaagaagg gaagtctgga cagtgacaat gatgattctg actgcccata ctcagaaaaa     3240

gttccaagta ttaaaattcc aatggacatc atggaacagc aacctttcct aagcgatagc     3300

aaaccttctg acagagaaag atcaccaaca ttccttgaac gccacacatc atgctgataa     3360

aattcctttc cttcagtcac tcggtatgcc aagtcctcct agaactccag taaaagttgt     3420

gcctcaaatt agaatagaac ttgaacctga agacaatgat tatttctgga ggagcaaggg     3480

aacagaaact acattgtaac ctgtttgtct ttcttaaaac tgacatttgt tgttaatgtc     3540

atttgttttt gtttggctgt ttgtttattt tttaactttt atttcgtctc agtttttggt     3600

cacaggccaa ataatacagc gctctctctg cttctctctt gcatagatac aatcaagaca     3660

atagtgcacc gttccttaaa aacagcatct gaggaatccc ccttttgttc ttaaactttc     3720

agatgtgtcc tttgataacc aaattctgtc actcaagaca cagacacgca cagaccctgt     3780

cctttgcctc tattaagcag aggatggaag tattaaggat tttgtaacac cttttatgaa     3840

aatgttgaag gaacttaaaa ctttagcttt ggagctgtgc ttactggctt gtctttgtct     3900

ggtagaacaa accttgacct ccagacagag tcccttctca cttatagagc tctccaggac     3960

tggaaaaagt gctgctattt taacttgctc ttgcttgtaa atcctaatct tagagttatc     4020

aaaagaagaa aaaactgaag gtactttact ccctatagag aaaccattgc catcattgta     4080

gcaagtgctg gaatgtccct tttttcctat gcaacttttt ttaacccttt aatgaactta     4140

tctgttgagt acattgaaga atatttttct tcctagattt tgttgtttaa attatggggc     4200

ctaacctgcc acttattttt tgtcaatttt taaaactttt ttttaattac tgtaaagaaa     4260

atgaattttt tcctgcagca ggaaacatag ttttgagtag ttctacctct tatttgtagc     4320

tgccaggctt tctgtaaaaa ttgtattgta tataatgtga tttttacaca tacatacaca     4380

cacaaataca caatctctag ggtaagccag aaggcaagat cagattaaaa acaccatgtt     4440

tctaagcatc catttttccc tttctttaaa agaaacttaa ctgttctatg aaggagattg     4500

agggagaaga gacaaactcc tatgtcatga gaataaccga tgttctgata atagtagcat     4560

ctaggtacag atgctggttg tattaccacg tcaatgtcct atgcagtatt gttagacatt     4620

ttctcatttt gaaatatttg tgtgtttgtg tatgtgctct gtgccatggc tggtgtatat     4680

atgtgcaatg ttagaaggca aaagagtgat ggtaggcaga gggcaaagtc attgaatctc     4740

ttatgccagt tttcataaaa cccaaaccac atatgaaaaa atccattaag ggtccaagaa     4800

gtctgtccat atgaaaatga gggtaaatat agtttatttc ccaggtatca gtcattataa     4860

ttgatataat agctctaaca tgcaatataa aattcatagg agtattaata gcccatttac     4920

acatctataa aatgtaatgg gattgcagag ctgcagagta cagtgtaaca gtactctcat     4980

gcaatttttt tcaggatgca aaggcaatta ttctttgtaa gcgggacatt tagaatatat     5040

ttgtgtacat attatatgta tgtatatttc aaagtaccac actgaaaatt agacatttat     5100

taaccaaatt taacgtggta tttaaaggta atatttttaa tatgatacat tacatattgt     5160

gaatgtatac taaaaaaaca ttttaaatgt taaaattata atttcagatt catataacca     5220

caactgtgat atatcctaac tataaccagt tgttgagggg tatactagaa gcagaatgaa     5280

accacatttt ttggtttgat aatatgcact tattgactcc cactcattgt tatgttaatt     5340

aagttattat tctgtctcct tgtaattttg attacaaaaa ttttattatc ctgagttagc     5400

tgttactttt acagtacctg atactcctaa aacttttaac ttatacaaat tagtcaataa     5460

tgaccccaat tttttcatta aaataatagt ggtgaattat atgttattgt gttaaaacct     5520

cacttgccaa attctggctt cacatttgta tttagggcta tccttaaaat gatgagtcta     5580

tattatctag ctttctatta ccctaatata aactggtata agaagacttt ccttttttct     5640

ttatgcatgg aagcatcaat aaattgttta aaaaccatgt atagtaaatt cagcttaacc     5700

cgtgatcttc ttaagttaaa ggtacttttg ttttataaaa gctctagata aaactttctt     5760

ttctgatcat gaatcaagta tctgtggttt catgcccctc tctatacctt tcaaagaact     5820

cctgaagcaa cttaactcat catttcagcc tctgagtaga ggtaaaacct atgtgtactt     5880

ctgtttatga tccatattga tatttatgac atgaacacag aatagtacct tacatttgct     5940

aaacagacag ttaatatcaa atcctttcaa tattctggga acccagggaa gtttttaaaa     6000

atgtcattac tttcaaagga acagaagtag ttaaccaaac taacaagcaa aacctgaggt     6060

ttacctagtg acaccaaatt atcggtattt taactgaatt tacccattga ctaagaatga     6120

accagatttg gtggtggttt tgtttctatg caaactggac acaaattaca acagtaaatt     6180

tttttataag tgcttctccc ttctccatga tgtgacttcc ggagataaag gattcaaaag     6240

ataaagacaa agtacgctca gagttgttaa ccagaaagtc ctggctgtgg ttgcagaaac     6300

actgttggaa gaaaagagat gactaagtca agtgtctgcc ttatcaaaag agcaaaaatg     6360

cctctggttt tgtgtttggg agaaaaatat cttggacgca ctgttttcct tgataaaagt     6420

catcttctct actgtgtgaa atgaatactt ggaattctaa ttgttttgtg tgccaggggc     6480

agtaatgtcc ctgcctcttc tcccaatcaa ggttgaggag tggggctggg gagaggactt     6540

aactgactta agaagtagga aaacaaaaac ctctctcctc agccttccac ctccaagaga     6600

ggaggaaaaa cagttgtctg ctgtctgtaa ttcagtttgc gtgtatttta tgctcatgca     6660

ccaacccata cagagtaaat cttttatcaa ctatatactg gtgtttaata gagaatgatt     6720

gtcttccgag ttttttggtt ccttttttaa ctgtgttaaa gtacttgaaa tgtattgact     6780

gctgactata ttttaaaaac aaaatgaaat aatttgagtt gtattacaga ggttgacatt     6840

gttcagggat gggacaaagc cttcttcaat ccttttcata ctacttaatg attttggtgc     6900

aggaacctga gattttctga tttatatttc atgatatttc acatttgctc ttcacagcat     6960

gagcatgaag cccagtggca ccaaatggct gggtacaatc aagtgatatt ttgtagcacc     7020

tcactatctg aaaggccatg agttttcaga tgatttcatt gagcttcatt gcagcctgaa     7080

attttaaaaa agttgtgtaa tacgccaacc agtcaagttg tgttttggcc agagatttag     7140

atatgtccaa tttcctggct catttcattg tgctctatgg gtacgtataa aaagcaagaa     7200

ttctgtttcc taggcaaaca ttgcaactca gggctaaagt catccagtga aacttttaga     7260

gccagaagta actttgtccc agtcctacaa tgtgaaaaga gtgaatagtt gcctcttttt     7320

agccattttc atggctggta catattcgta cgcattactt ttcagaatca atacgcactt     7380

tcagatattc ttatttttat tctcttaagt ctttattaac tttggagaga gaaatgatgc     7440

atctttttat tttaaatgaa gtagatcaac atggtggaac aaaatgataa agaacagaaa     7500

acatttcaat atattactaa taactttttc caatataaat cctaaaattc ctataacata     7560

gtattttaca gttttatgaa gctttctatt gtgactttta tggaattaag agatgaagaa     7620

gatgagatat tttagcattt atatttttca aaattatatg tatacttaaa aataaagtaa     7680

ctttatgcat tta                                                        7693


<210>  58
<211>  1079
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Glu Asp Glu Ala Val Leu Asp Arg Gly Ala Ser Phe Leu Lys His 
1               5                   10                  15      


Val Cys Asp Glu Glu Glu Val Glu Gly His His Thr Ile Tyr Ile Gly 
            20                  25                  30          


Val His Val Pro Lys Ser Tyr Arg Arg Arg Arg Arg His Lys Arg Lys 
        35                  40                  45              


Thr Gly His Lys Glu Lys Lys Glu Lys Glu Arg Ile Ser Glu Asn Tyr 
    50                  55                  60                  


Ser Asp Lys Ser Asp Ile Glu Asn Ala Asp Glu Ser Ser Ser Ser Ile 
65                  70                  75                  80  


Leu Lys Pro Leu Ile Ser Pro Ala Ala Glu Arg Ile Arg Phe Ile Leu 
                85                  90                  95      


Gly Glu Glu Asp Asp Ser Pro Ala Pro Pro Gln Leu Phe Thr Glu Leu 
            100                 105                 110         


Asp Glu Leu Leu Ala Val Asp Gly Gln Glu Met Glu Trp Lys Glu Thr 
        115                 120                 125             


Ala Arg Trp Ile Lys Phe Glu Glu Lys Val Glu Gln Gly Gly Glu Arg 
    130                 135                 140                 


Trp Ser Lys Pro His Val Ala Thr Leu Ser Leu His Ser Leu Phe Glu 
145                 150                 155                 160 


Leu Arg Thr Cys Met Glu Lys Gly Ser Ile Met Leu Asp Arg Glu Ala 
                165                 170                 175     


Ser Ser Leu Pro Gln Leu Val Glu Met Ile Val Asp His Gln Ile Glu 
            180                 185                 190         


Thr Gly Leu Leu Lys Pro Glu Leu Lys Asp Lys Val Thr Tyr Thr Leu 
        195                 200                 205             


Leu Arg Lys His Arg His Gln Thr Lys Lys Ser Asn Leu Arg Ser Leu 
    210                 215                 220                 


Ala Asp Ile Gly Lys Thr Val Ser Ser Ala Ser Arg Met Phe Thr Asn 
225                 230                 235                 240 


Pro Asp Asn Gly Ser Pro Ala Met Thr His Arg Asn Leu Thr Ser Ser 
                245                 250                 255     


Ser Leu Asn Asp Ile Ser Asp Lys Pro Glu Lys Asp Gln Leu Lys Asn 
            260                 265                 270         


Lys Phe Met Lys Lys Leu Pro Arg Asp Ala Glu Ala Ser Asn Val Leu 
        275                 280                 285             


Val Gly Glu Val Asp Phe Leu Asp Thr Pro Phe Ile Ala Phe Val Arg 
    290                 295                 300                 


Leu Gln Gln Ala Val Met Leu Gly Ala Leu Thr Glu Val Pro Val Pro 
305                 310                 315                 320 


Thr Arg Phe Leu Phe Ile Leu Leu Gly Pro Lys Gly Lys Ala Lys Ser 
                325                 330                 335     


Tyr His Glu Ile Gly Arg Ala Ile Ala Thr Leu Met Ser Asp Glu Val 
            340                 345                 350         


Phe His Asp Ile Ala Tyr Lys Ala Lys Asp Arg His Asp Leu Ile Ala 
        355                 360                 365             


Gly Ile Asp Glu Phe Leu Asp Glu Val Ile Val Leu Pro Pro Gly Glu 
    370                 375                 380                 


Trp Asp Pro Ala Ile Arg Ile Glu Pro Pro Lys Ser Leu Pro Ser Ser 
385                 390                 395                 400 


Asp Lys Arg Lys Asn Met Tyr Ser Gly Gly Glu Asn Val Gln Met Asn 
                405                 410                 415     


Gly Asp Thr Pro His Asp Gly Gly His Gly Gly Gly Gly His Gly Asp 
            420                 425                 430         


Cys Glu Glu Leu Gln Arg Thr Gly Arg Phe Cys Gly Gly Leu Ile Lys 
        435                 440                 445             


Asp Ile Lys Arg Lys Ala Pro Phe Phe Ala Ser Asp Phe Tyr Asp Ala 
    450                 455                 460                 


Leu Asn Ile Gln Ala Leu Ser Ala Ile Leu Phe Ile Tyr Leu Ala Thr 
465                 470                 475                 480 


Val Thr Asn Ala Ile Thr Phe Gly Gly Leu Leu Gly Asp Ala Thr Asp 
                485                 490                 495     


Asn Met Gln Gly Val Leu Glu Ser Phe Leu Gly Thr Ala Val Ser Gly 
            500                 505                 510         


Ala Ile Phe Cys Leu Phe Ala Gly Gln Pro Leu Thr Ile Leu Ser Ser 
        515                 520                 525             


Thr Gly Pro Val Leu Val Phe Glu Arg Leu Leu Phe Asn Phe Ser Lys 
    530                 535                 540                 


Asp Asn Asn Phe Asp Tyr Leu Glu Phe Arg Leu Trp Ile Gly Leu Trp 
545                 550                 555                 560 


Ser Ala Phe Leu Cys Leu Ile Leu Val Ala Thr Asp Ala Ser Phe Leu 
                565                 570                 575     


Val Gln Tyr Phe Thr Arg Phe Thr Glu Glu Gly Phe Ser Ser Leu Ile 
            580                 585                 590         


Ser Phe Ile Phe Ile Tyr Asp Ala Phe Lys Lys Met Ile Lys Leu Ala 
        595                 600                 605             


Asp Tyr Tyr Pro Ile Asn Ser Asn Phe Lys Val Gly Tyr Asn Thr Leu 
    610                 615                 620                 


Phe Ser Cys Thr Cys Val Pro Pro Asp Pro Ala Asn Ile Ser Ile Ser 
625                 630                 635                 640 


Asn Asp Thr Thr Leu Ala Pro Glu Tyr Leu Pro Thr Met Ser Ser Thr 
                645                 650                 655     


Asp Met Tyr His Asn Thr Thr Phe Asp Trp Ala Phe Leu Ser Lys Lys 
            660                 665                 670         


Glu Cys Ser Lys Tyr Gly Gly Asn Leu Val Gly Asn Asn Cys Asn Phe 
        675                 680                 685             


Val Pro Asp Ile Thr Leu Met Ser Phe Ile Leu Phe Leu Gly Thr Tyr 
    690                 695                 700                 


Thr Ser Ser Met Ala Leu Lys Lys Phe Lys Thr Ser Pro Tyr Phe Pro 
705                 710                 715                 720 


Thr Thr Ala Arg Lys Leu Ile Ser Asp Phe Ala Ile Ile Leu Ser Ile 
                725                 730                 735     


Leu Ile Phe Cys Val Ile Asp Ala Leu Val Gly Val Asp Thr Pro Lys 
            740                 745                 750         


Leu Ile Val Pro Ser Glu Phe Lys Pro Thr Ser Pro Asn Arg Gly Trp 
        755                 760                 765             


Phe Val Pro Pro Phe Gly Glu Asn Pro Trp Trp Val Cys Leu Ala Ala 
    770                 775                 780                 


Ala Ile Pro Ala Leu Leu Val Thr Ile Leu Ile Phe Met Asp Gln Gln 
785                 790                 795                 800 


Ile Thr Ala Val Ile Val Asn Arg Lys Glu His Lys Leu Lys Lys Gly 
                805                 810                 815     


Ala Gly Tyr His Leu Asp Leu Phe Trp Val Ala Ile Leu Met Val Ile 
            820                 825                 830         


Cys Ser Leu Met Ala Leu Pro Trp Tyr Val Ala Ala Thr Val Ile Ser 
        835                 840                 845             


Ile Ala His Ile Asp Ser Leu Lys Met Glu Thr Glu Thr Ser Ala Pro 
    850                 855                 860                 


Gly Glu Gln Pro Lys Phe Leu Gly Val Arg Glu Gln Arg Val Thr Gly 
865                 870                 875                 880 


Thr Leu Val Phe Ile Leu Thr Gly Leu Ser Val Phe Met Ala Pro Ile 
                885                 890                 895     


Leu Lys Phe Ile Pro Met Pro Val Leu Tyr Gly Val Phe Leu Tyr Met 
            900                 905                 910         


Gly Val Ala Ser Leu Asn Gly Val Gln Phe Met Asp Arg Leu Lys Leu 
        915                 920                 925             


Leu Leu Met Pro Leu Lys His Gln Pro Asp Phe Ile Tyr Leu Arg His 
    930                 935                 940                 


Val Pro Leu Arg Arg Val His Leu Phe Thr Phe Leu Gln Val Leu Cys 
945                 950                 955                 960 


Leu Ala Leu Leu Trp Ile Leu Lys Ser Thr Val Ala Ala Ile Ile Phe 
                965                 970                 975     


Pro Val Met Ile Leu Ala Leu Val Ala Val Arg Lys Gly Met Asp Tyr 
            980                 985                 990         


Leu Phe Ser Gln His Asp Leu Ser  Phe Leu Asp Asp Val  Ile Pro Glu 
        995                 1000                 1005             


Lys Asp  Lys Lys Lys Lys Glu  Asp Glu Lys Lys Lys  Lys Lys Lys 
    1010                 1015                 1020             


Lys Gly  Ser Leu Asp Ser Asp  Asn Asp Asp Ser Asp  Cys Pro Tyr 
    1025                 1030                 1035             


Ser Glu  Lys Val Pro Ser Ile  Lys Ile Pro Met Asp  Ile Met Glu 
    1040                 1045                 1050             


Gln Gln  Pro Phe Leu Ser Asp  Ser Lys Pro Ser Asp  Arg Glu Arg 
    1055                 1060                 1065             


Ser Pro  Thr Phe Leu Glu Arg  His Thr Ser Cys 
    1070                 1075                 


<210>  59
<211>  3597
<212>  DNA
<213>  Homo sapiens

<400>  59
gaccgaccct ccggctccac gccctttttt tttttttttt ttaggtcccg ggcgttgagc       60

tctactcagt gcacgcagcc acacaatatg ctcttggacg tcgccccctg gaggggatgt      120

tatctcccgc ctccttgaag tcgcccattt ctggggttgc cccatccagg gagctggttc      180

ctagttaaga atatgagaat gtatgcgcag ggaggcaggc aacagcacga acagccacgc      240

ttctagaaga ttctagggag cgcgcaggag cagcgcagag ggagtaggaa tgagcaggcg      300

gaggacccga ggtcacgaga ccgttgggtg ggaggagcca gcggccgggg aggttctagt      360

ctgttctgtc ttgcggcagc cgcccccttc tgcgcggtca cgccgagcca gcgcctgggc      420

ctggaaccgg gccgtagccc ccccagtttc gcccaccacc tccctaccat ggacccccgc      480

aaagtgaacg agcttcgggc ctttgtgaaa atgtgtaagc aggatccgag cgttctgcac      540

accgaggaaa tgcgcttcct gagggagtgg gtggagagca tgggtggtaa agtaccacct      600

gctactcaga aagctaaatc agaagaaaat accaaggaag aaaaacctga tagtaagaag      660

gtggaggaag acttaaaggc agacgaacca tcaagtgagg aaagtgatct agaaattgat      720

aaagaaggtg tgattgaacc agacactgat gctcctcaag aaatgggaga tgaaaatgcg      780

gagataacgg aggagatgat ggatcaggca aatgataaaa aagtggctgc tattgaagcc      840

ctaaatgatg gtgaactcca gaaagccatt gacttattca cagatgccat caagctgaat      900

cctcgcttgg ccattttgta tgccaagagg gccagtgtct tcgtcaaatt acagaagcca      960

aatgctgcca tccgagactg tgacagagcc attgaaataa atcctgattc agctcagcct     1020

tacaagtggc gggggaaagc acacagactt ctaggccact gggaagaagc agcccatgat     1080

cttgcccttg cctgtaaatt ggattatgat gaagatgcta gtgcaatgct gaaagaagtt     1140

caacctaggg cacagaaaat tgcagaacat cggagaaagt atgagcgaaa acgtgaagag     1200

cgagagatca aagaaagaat agaacgagtt aagaaggctc gagaagagca tgagagagcc     1260

cagagggagg aagaagccag acgacagtca ggagctcagt atggctcttt tccaggtggc     1320

tttcctgggg gaatgcctgg taattttccc ggaggaatgc ctggaatggg agggggcatg     1380

cctggaatgg ctggaatgcc tggactcaat gaaattctta gtgatccaga ggttcttgca     1440

gccatgcagg atccagaagt tatggtggct ttccaggatg tggctcagaa cccagcaaat     1500

atgtcaaaat accagagcaa cccaaaggtt atgaatctca tcagtaaatt gtcagccaaa     1560

tttggaggtc aagcgtaatg tccttctgat aaataaagcc cttgctgaag gaaaagcaac     1620

ctagatcacc ttatggatgt cgcaataata caaaccagtg tacctctgac cttctcatca     1680

agagagctgg ggtgctttga agataatccc tacccctctc ccccaaatgc agctgaagca     1740

ttttacagtg gtttgccatt agggtattca ttcagataat gttttcctac taggaattac     1800

aaactttaaa cactttttaa atcttcaaaa tatttaaaac aaatttaaag ggcctgttaa     1860

ttcttatatt tttctttact aatcattttg gatttttttc tttgaattat tggcagggaa     1920

tatacttatg tatggaagat tactgctctg agtgaaataa aagttattag tgcgaggcaa     1980

acataactca tttgaggata aagtttgtgt tggatatgtg gttcctgatg cattttgact     2040

tgtcttttta aatgctttat ctttttcttt aaagatttat ttcaataaaa ctaattggga     2100

ccacccgtat ttcagtagga cctgggtagg gattggaagt acttggcagg gcagcagcaa     2160

tcttgctgtg tttgatataa catgcatcct tgggcaggtt gcccttaaat cttacactgt     2220

ggtgaaggga tgtttttttt gtaatgctgc agtagagttg gagtacttag ttctcttgtt     2280

gtccagtata tctaataagt gtttttcata ttatttccac gtaagggaaa taaggtagta     2340

cttttctttt tatatttcta tgcttaaaat tctctttcct agtcaaaaat tgcccaaatc     2400

tgtgtttgct ttctgcttgc tacatttgtc tcccttactt ttcttgagct aaagacaggc     2460

tttttccacc ggcatcatca ctgctatcat cattaacagc gtaattatac aagcatattt     2520

aatgctgagt ttaatttaat atgtaataca tatggtaatt gtagggtaat acccacaaca     2580

actgtagttt cttacttggc caagagaatg cttatttaag tgttagactt ccattctggc     2640

aaaatcttgc cttatcagaa gacattggaa agagggattc cctttggtgt ttggtcttct     2700

acttagaaaa acctattgca gttagtttat cttgtagtat tcatctttgt attctgaaga     2760

taaggtttga attaaattga tacacacaga ggggaaccga ttttttttat ccaatgtgaa     2820

ttataaatga gataatccac agttattcat tgtggagttg ttgagactat gaaagactca     2880

ttgtctttgt attcagctct taaatagtgt aactatatcc ccacctctgc ttgctttctt     2940

tccctcccct ccaatgataa agaaaatgat aaattttctg ttgtgcattc aattcttatt     3000

ttaaataaga ctaagtatag gcattgtacc tgacattgct acgtttctac cagtgtttca     3060

atttaaagtg ctagtgttta aaaacatttt caagggataa ggccttctgt actttgctta     3120

tttgaagaat cagtggtagg agcagtgaag taaattctat ggagtacatt tctaaaatac     3180

cacatttctg aaatcataaa taagtttatt caggttctaa ccctttgctg tacacaagca     3240

gacagaaatg catctgttac ataaatgaga aaaagctatt atgctgatgg agcatgcttt     3300

ttaaatcctt taaaaacact caccatataa acttgcattt gagcttgtgt gttcttttgt     3360

taatgtgtag agttctcctt tctcgaaatt gccagtgtgt acttggctta actcaagaac     3420

agtttcttct ggattcctta tttgatttat ttaacctaat tatattctaa tattgcaaat     3480

attaccataa gtgggtaaaa gtaaaattcc tcttctgaaa atgtgtcctg tgcttttaga     3540

tttttaaatt ccataatata cattcttaat tttcaactca aaaaaaaaaa aaaaaaa        3597


<210>  60
<211>  369
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Asp Pro Arg Lys Val Asn Glu Leu Arg Ala Phe Val Lys Met Cys 
1               5                   10                  15      


Lys Gln Asp Pro Ser Val Leu His Thr Glu Glu Met Arg Phe Leu Arg 
            20                  25                  30          


Glu Trp Val Glu Ser Met Gly Gly Lys Val Pro Pro Ala Thr Gln Lys 
        35                  40                  45              


Ala Lys Ser Glu Glu Asn Thr Lys Glu Glu Lys Pro Asp Ser Lys Lys 
    50                  55                  60                  


Val Glu Glu Asp Leu Lys Ala Asp Glu Pro Ser Ser Glu Glu Ser Asp 
65                  70                  75                  80  


Leu Glu Ile Asp Lys Glu Gly Val Ile Glu Pro Asp Thr Asp Ala Pro 
                85                  90                  95      


Gln Glu Met Gly Asp Glu Asn Ala Glu Ile Thr Glu Glu Met Met Asp 
            100                 105                 110         


Gln Ala Asn Asp Lys Lys Val Ala Ala Ile Glu Ala Leu Asn Asp Gly 
        115                 120                 125             


Glu Leu Gln Lys Ala Ile Asp Leu Phe Thr Asp Ala Ile Lys Leu Asn 
    130                 135                 140                 


Pro Arg Leu Ala Ile Leu Tyr Ala Lys Arg Ala Ser Val Phe Val Lys 
145                 150                 155                 160 


Leu Gln Lys Pro Asn Ala Ala Ile Arg Asp Cys Asp Arg Ala Ile Glu 
                165                 170                 175     


Ile Asn Pro Asp Ser Ala Gln Pro Tyr Lys Trp Arg Gly Lys Ala His 
            180                 185                 190         


Arg Leu Leu Gly His Trp Glu Glu Ala Ala His Asp Leu Ala Leu Ala 
        195                 200                 205             


Cys Lys Leu Asp Tyr Asp Glu Asp Ala Ser Ala Met Leu Lys Glu Val 
    210                 215                 220                 


Gln Pro Arg Ala Gln Lys Ile Ala Glu His Arg Arg Lys Tyr Glu Arg 
225                 230                 235                 240 


Lys Arg Glu Glu Arg Glu Ile Lys Glu Arg Ile Glu Arg Val Lys Lys 
                245                 250                 255     


Ala Arg Glu Glu His Glu Arg Ala Gln Arg Glu Glu Glu Ala Arg Arg 
            260                 265                 270         


Gln Ser Gly Ala Gln Tyr Gly Ser Phe Pro Gly Gly Phe Pro Gly Gly 
        275                 280                 285             


Met Pro Gly Asn Phe Pro Gly Gly Met Pro Gly Met Gly Gly Gly Met 
    290                 295                 300                 


Pro Gly Met Ala Gly Met Pro Gly Leu Asn Glu Ile Leu Ser Asp Pro 
305                 310                 315                 320 


Glu Val Leu Ala Ala Met Gln Asp Pro Glu Val Met Val Ala Phe Gln 
                325                 330                 335     


Asp Val Ala Gln Asn Pro Ala Asn Met Ser Lys Tyr Gln Ser Asn Pro 
            340                 345                 350         


Lys Val Met Asn Leu Ile Ser Lys Leu Ser Ala Lys Phe Gly Gly Gln 
        355                 360                 365             


Ala 
    


<210>  61
<211>  3224
<212>  DNA
<213>  Homo sapiens

<400>  61
gtcccacatc ccgcatccgg catcccagcg gccgggcatg tagcagcggc agcaacggcg       60

gaatatgggc gggaaccact cccacaagcc ccccgtgttt gacgagaatg aggaagtcaa      120

ctttgaccat tttcagattc tgcgggccat tggtaaaggg agttttggaa aggtatgcat      180

cgtgcagaag cgagacacta agaaaatgta tgcaatgaag tacatgaaca agcagaagtg      240

catcgagagg gatgaggttc ggaatgtttt ccgggagctg cagatcatgc aagggctgga      300

gcaccccttc ctggtcaatc tgtggtactc cttccaggat gaggaggaca tgttcatggt      360

ggtggacctg ctcctgggag gcgacctgcg ctaccatctg cagcagaatg tgcatttcac      420

agaggggact gtgaaactct acatctgtga gctggcactg gccctggagt atcttcagag      480

gtaccacatc atccacagag acatcaagcc agacaatatc ctgctggatg aacacggaca      540

tgttcacatt acagacttca acatagcgac ggtagtgaaa ggagcagaaa gggcttcctc      600

catggctggc accaagccct acatggctcc agaagtattc caggtgtaca tggacagagg      660

ccccggatac tcgtaccctg tcgactggtg gtccctgggc atcacagcct atgagctgct      720

gcggggctgg aggccgtacg aaatccactc ggtcacgccc atcgatgaaa tcctcaacat      780

gttcaaggtg gagcgtgtcc actactcctc cacgtggtgc aaggggatgg tggccctgct      840

gaggaagctc ctgaccaagg atcctgagag ccgcgtgtcc agccttcatg acatacagag      900

cgtgccctac ttggccgaca tgaactggga cgcggtgttc aagaaggcac tgatgcccgg      960

ctttgtgccc aataaaggga ggttgaactg cgatcccaca tttgagcttg aagagatgat     1020

tctagaatcc aagccacttc acaaaaagaa gaagcgattg gcaaagaaca gatccaggga     1080

tggcacaaag gacagctgcc cgctgaatgg acacctgcag cactgtttgg agactgtccg     1140

ggaggaattc atcatattca acagagagaa gctcaggagg cagcagggac agggcagcca     1200

gctcttggac accgacagcc gagggggagg ccaggcccaa agcaagctcc aggacgggtg     1260

caacaacaac ctcctcaccc acacctgcac ccgtggctgc agcagctgag cccacacttg     1320

ttgctgctca acaggactgc actcgtctct gccctgccca cccagagccc ctctttgtgc     1380

cctgatggtc cctgtctcac ccctgaaaac atcagatgca gaaaaagccc tggacttgga     1440

gctgggaagc ctgggttctg gtcccatctc catgactgat tcacgtgtga cctcagacaa     1500

gtcacgccct ctctgtgcct ccgttttctg catctgccaa aggggttaaa cacttctgcc     1560

ccacttcaaa ttacaagatt atggggagaa cccaattagg taggaaacat gaaaaacctt     1620

tgatatttat aaaatcattt ttacgtgcaa aatataacct taatatttga agtgaccccc     1680

attccccaaa gcaatcaaac cgtcatgact ttgcaatttg gcacatccta gcttgttaga     1740

gggcacttcc gaaaaacaca gccctgacag caaaataaag gtctgatatg ttggcccctt     1800

ctatggaaac aacgctgcca aatcctggag caaaacctga agtgtcttca tgtgcattct     1860

ctggcaggcc acagtcctga gcttgtaaga tggtgcagca tgcagaccag acttgtcccc     1920

aaggtctcag cgctgcggtc tcactcctcc cctcatttaa gaagactatc cttacctttt     1980

agtttcagca gtcctcacca ccaccatatc cccagtgctg ggatggcaca caggtgtcca     2040

ttcagatgag agttgggtcg ctgagcattg gttactcctg cagagtgtaa tcagcacccc     2100

atccaactgg cccgaaagcc cagacctgca gcagaactct ccaactctct atcagctttc     2160

agggttttct ctcctgggaa gggtgtaaaa tcagcttgtc agattcttct tacagagagt     2220

atccaatcgg tattggtgga gcggctccct atttatacaa taggaagcat gggtgcttag     2280

aaagtttatt tcaggaggaa aatgggttca cacaaaaagc aaactacatt ctgatctgct     2340

cagggagaag cttgcctttg aactggaaga tgttgggatg agcagggaaa gcttagactt     2400

tggagtcagg tttgtgttca gaatccagcc ctgctggcta ctaactaact gggagacctt     2460

aggcaaagca tgcaatcgct ctgaatggca gtttcctcat ttttaaacag ggataataaa     2520

actaatattg caggggagtt acagggttaa ataagatcct gtgtgtaacc ccaagcattg     2580

gatgactcat agaatggcct tttttgtcag cataatcgtc atcattattt agatactttc     2640

ttccttcact cacccagcag gtcagttttc tgtgcaaaca aacctgttta ggattcttcc     2700

aaatgttctt cctggggtct ttgatatttg tttgttacat cctgctgaag ttcgactgtg     2760

tttttatttt ttcatccaac ttccattttt cactttttac atgattactc aatccttggg     2820

gctgtccatg tcatctctta gatttcttaa aagacatttt aatgtatggt taggttttat     2880

atttttattt tttaaaaaag aaatagtcag tgttttcctc ctttcaaccg agactatttc     2940

tggattgtgt gctcctcgtc agttgacttg ttttgcacac ttttctttac ttcatgtccc     3000

catcaacaac cgtcctgctc cccacctccc ccaggaaata aggggcctgc tcctctccct     3060

actgtgaccc tggaggctct taagatgatg atggtttttt ttattgggct gagttcacga     3120

attaggggca ggagctggaa gtcgccctag gaacaccaga tttcctggtt ctgttcaagt     3180

tggcatttct tgtttggaat aaactatttc ttggacattc cttc                      3224


<210>  62
<211>  414
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Gly Gly Asn His Ser His Lys Pro Pro Val Phe Asp Glu Asn Glu 
1               5                   10                  15      


Glu Val Asn Phe Asp His Phe Gln Ile Leu Arg Ala Ile Gly Lys Gly 
            20                  25                  30          


Ser Phe Gly Lys Val Cys Ile Val Gln Lys Arg Asp Thr Lys Lys Met 
        35                  40                  45              


Tyr Ala Met Lys Tyr Met Asn Lys Gln Lys Cys Ile Glu Arg Asp Glu 
    50                  55                  60                  


Val Arg Asn Val Phe Arg Glu Leu Gln Ile Met Gln Gly Leu Glu His 
65                  70                  75                  80  


Pro Phe Leu Val Asn Leu Trp Tyr Ser Phe Gln Asp Glu Glu Asp Met 
                85                  90                  95      


Phe Met Val Val Asp Leu Leu Leu Gly Gly Asp Leu Arg Tyr His Leu 
            100                 105                 110         


Gln Gln Asn Val His Phe Thr Glu Gly Thr Val Lys Leu Tyr Ile Cys 
        115                 120                 125             


Glu Leu Ala Leu Ala Leu Glu Tyr Leu Gln Arg Tyr His Ile Ile His 
    130                 135                 140                 


Arg Asp Ile Lys Pro Asp Asn Ile Leu Leu Asp Glu His Gly His Val 
145                 150                 155                 160 


His Ile Thr Asp Phe Asn Ile Ala Thr Val Val Lys Gly Ala Glu Arg 
                165                 170                 175     


Ala Ser Ser Met Ala Gly Thr Lys Pro Tyr Met Ala Pro Glu Val Phe 
            180                 185                 190         


Gln Val Tyr Met Asp Arg Gly Pro Gly Tyr Ser Tyr Pro Val Asp Trp 
        195                 200                 205             


Trp Ser Leu Gly Ile Thr Ala Tyr Glu Leu Leu Arg Gly Trp Arg Pro 
    210                 215                 220                 


Tyr Glu Ile His Ser Val Thr Pro Ile Asp Glu Ile Leu Asn Met Phe 
225                 230                 235                 240 


Lys Val Glu Arg Val His Tyr Ser Ser Thr Trp Cys Lys Gly Met Val 
                245                 250                 255     


Ala Leu Leu Arg Lys Leu Leu Thr Lys Asp Pro Glu Ser Arg Val Ser 
            260                 265                 270         


Ser Leu His Asp Ile Gln Ser Val Pro Tyr Leu Ala Asp Met Asn Trp 
        275                 280                 285             


Asp Ala Val Phe Lys Lys Ala Leu Met Pro Gly Phe Val Pro Asn Lys 
    290                 295                 300                 


Gly Arg Leu Asn Cys Asp Pro Thr Phe Glu Leu Glu Glu Met Ile Leu 
305                 310                 315                 320 


Glu Ser Lys Pro Leu His Lys Lys Lys Lys Arg Leu Ala Lys Asn Arg 
                325                 330                 335     


Ser Arg Asp Gly Thr Lys Asp Ser Cys Pro Leu Asn Gly His Leu Gln 
            340                 345                 350         


His Cys Leu Glu Thr Val Arg Glu Glu Phe Ile Ile Phe Asn Arg Glu 
        355                 360                 365             


Lys Leu Arg Arg Gln Gln Gly Gln Gly Ser Gln Leu Leu Asp Thr Asp 
    370                 375                 380                 


Ser Arg Gly Gly Gly Gln Ala Gln Ser Lys Leu Gln Asp Gly Cys Asn 
385                 390                 395                 400 


Asn Asn Leu Leu Thr His Thr Cys Thr Arg Gly Cys Ser Ser 
                405                 410                 


<210>  63
<211>  1586
<212>  DNA
<213>  Homo sapiens

<400>  63
cgcccccgcc gggcgtgtgt gtcgtgtgtg tttggggccc gcgcgggttg cgcgccctcc       60

gccttcgcgc ctcctgcccc cgaggcccta ctgctgcccc tgtgcccctc gccccgccgg      120

gcgtcgcggg ccaacatggg ccaggaagag gagctgctga ggatcgccaa aaagctggag      180

aagatggtgg ccaggaagaa cacggaaggg gccctggacc ttctgaagaa gctgcacagc      240

tgccagatgt ccatccagct actacagaca accaggattg gagttgctgt taatggggtc      300

cgcaagcact gctcagacaa ggaggtggtg tccttggcca aagtccttat caaaaactgg      360

aagcggctgc tagactcccc tggaccccca aaaggagaaa aaggagagga aagagaaaag      420

gcaaagaaga aggaaaaagg gcttgagtgt tcagactgga agccagaagc aggcctttct      480

ccaccaagga aaaaacgaga agaccccaaa accaggagag actctgtgga ctccaagtct      540

tctgcctcct cctctccaaa aagaccatcg gtggaaagat caaacagcag caaatcaaaa      600

gcggagagcc ccaaaacacc tagcagcccc ttgaccccca cgtttgcctc ttccatgtgt      660

ctcctggccc cctgctatct cacaggggac tctgtccggg acaagtgtgt ggagatgctg      720

tcagcagccc tgaaggcgga cgatgattac aaggactatg gagtcaactg tgacaagatg      780

gcatcagaaa tcgaagatca tatctaccaa gagctcaaga gcacggacat gaagtaccgg      840

aaccgcgtgc gcagccgcat aagcaacctc aaggacccca ggaaccccgg cctgcggcgg      900

aacgtgctca gtggggccat ctccgcaggg cttatagcca agatgacggc agaggaaatg      960

gccagtgatg aactgaggga gttgaggaat gccatgaccc aggaggccat ccgtgagcac     1020

cagatggcca agactggcgg caccaccact gacctcttcc agtgcagcaa atgcaagaag     1080

aagaactgca cctataacca ggtgcagaca cgcagtgctg atgagcccat gactaccttt     1140

gtcttatgca atgaatgtgg caatcgctgg aagttctgct gatggaacag ccagccatga     1200

acaaggtgag gaagaagaaa gaggaagcgc tgaattatct gaactggaga agcaataaaa     1260

attaaagtga aggaaaatac tgaactctgt ctgagtggga tggtatgagt tagaggaaga     1320

attctcttgc aaattaataa tcggtcatta gaaacaattg gttaatgggg gagcctaatt     1380

ggagaatgat gctgagaatt tgtattgatg aacctctttt agaaactgca gagggctggg     1440

cacggtggtt tatggctgta atctgcaaac tctgggaggc tgaggtggga gaatcgctta     1500

accccagaag tttgagtcca gcccaggcaa cacagcaaga ccccatctct ataaaaagaa     1560

aaaataaaga aactgcagcg ccttag                                          1586


<210>  64
<211>  348
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Gly Gln Glu Glu Glu Leu Leu Arg Ile Ala Lys Lys Leu Glu Lys 
1               5                   10                  15      


Met Val Ala Arg Lys Asn Thr Glu Gly Ala Leu Asp Leu Leu Lys Lys 
            20                  25                  30          


Leu His Ser Cys Gln Met Ser Ile Gln Leu Leu Gln Thr Thr Arg Ile 
        35                  40                  45              


Gly Val Ala Val Asn Gly Val Arg Lys His Cys Ser Asp Lys Glu Val 
    50                  55                  60                  


Val Ser Leu Ala Lys Val Leu Ile Lys Asn Trp Lys Arg Leu Leu Asp 
65                  70                  75                  80  


Ser Pro Gly Pro Pro Lys Gly Glu Lys Gly Glu Glu Arg Glu Lys Ala 
                85                  90                  95      


Lys Lys Lys Glu Lys Gly Leu Glu Cys Ser Asp Trp Lys Pro Glu Ala 
            100                 105                 110         


Gly Leu Ser Pro Pro Arg Lys Lys Arg Glu Asp Pro Lys Thr Arg Arg 
        115                 120                 125             


Asp Ser Val Asp Ser Lys Ser Ser Ala Ser Ser Ser Pro Lys Arg Pro 
    130                 135                 140                 


Ser Val Glu Arg Ser Asn Ser Ser Lys Ser Lys Ala Glu Ser Pro Lys 
145                 150                 155                 160 


Thr Pro Ser Ser Pro Leu Thr Pro Thr Phe Ala Ser Ser Met Cys Leu 
                165                 170                 175     


Leu Ala Pro Cys Tyr Leu Thr Gly Asp Ser Val Arg Asp Lys Cys Val 
            180                 185                 190         


Glu Met Leu Ser Ala Ala Leu Lys Ala Asp Asp Asp Tyr Lys Asp Tyr 
        195                 200                 205             


Gly Val Asn Cys Asp Lys Met Ala Ser Glu Ile Glu Asp His Ile Tyr 
    210                 215                 220                 


Gln Glu Leu Lys Ser Thr Asp Met Lys Tyr Arg Asn Arg Val Arg Ser 
225                 230                 235                 240 


Arg Ile Ser Asn Leu Lys Asp Pro Arg Asn Pro Gly Leu Arg Arg Asn 
                245                 250                 255     


Val Leu Ser Gly Ala Ile Ser Ala Gly Leu Ile Ala Lys Met Thr Ala 
            260                 265                 270         


Glu Glu Met Ala Ser Asp Glu Leu Arg Glu Leu Arg Asn Ala Met Thr 
        275                 280                 285             


Gln Glu Ala Ile Arg Glu His Gln Met Ala Lys Thr Gly Gly Thr Thr 
    290                 295                 300                 


Thr Asp Leu Phe Gln Cys Ser Lys Cys Lys Lys Lys Asn Cys Thr Tyr 
305                 310                 315                 320 


Asn Gln Val Gln Thr Arg Ser Ala Asp Glu Pro Met Thr Thr Phe Val 
                325                 330                 335     


Leu Cys Asn Glu Cys Gly Asn Arg Trp Lys Phe Cys 
            340                 345             


<210>  65
<211>  3057
<212>  DNA
<213>  Homo sapiens

<400>  65
cactttcgag agtgccgtct atttgccaca cacttccctg atgaaatgtc tggatttgga       60

ctaaagaaaa aaggaaaggc tagcagtcat ccaacagaat catgagacag actttgcctt      120

gtatctactt ttgggggggc cttttgccct ttgggatgct gtgtgcatcc tccaccacca      180

agtgcactgt tagccatgaa gttgctgact gcagccacct gaagttgact caggtacccg      240

atgatctacc cacaaacata acagtgttga accttaccca taatcaactc agaagattac      300

cagccgccaa cttcacaagg tatagccagc taactagctt ggatgtagga tttaacacca      360

tctcaaaact ggagccagaa ttgtgccaga aacttcccat gttaaaagtt ttgaacctcc      420

agcacaatga gctatctcaa ctttctgata aaacctttgc cttctgcacg aatttgactg      480

aactccatct catgtccaac tcaatccaga aaattaaaaa taatcccttt gtcaagcaga      540

agaatttaat cacattagat ctgtctcata atggcttgtc atctacaaaa ttaggaactc      600

aggttcagct ggaaaatctc caagagcttc tattatcaaa caataaaatt caagcgctaa      660

aaagtgaaga actggatatc tttgccaatt catctttaaa aaaattagag ttgtcatcga      720

atcaaattaa agagttttct ccagggtgtt ttcacgcaat tggaagatta tttggcctct      780

ttctgaacaa tgtccagctg ggtcccagcc ttacagagaa gctatgtttg gaattagcaa      840

acacaagcat tcggaatctg tctctgagta acagccagct gtccaccacc agcaatacaa      900

ctttcttggg actaaagtgg acaaatctca ctatgctcga tctttcctac aacaacttaa      960

atgtggttgg taacgattcc tttgcttggc ttccacaact agaatatttc ttcctagagt     1020

ataataatat acagcatttg ttttctcact ctttgcacgg gcttttcaat gtgaggtacc     1080

tgaatttgaa acggtctttt actaaacaaa gtatttccct tgcctcactc cccaagattg     1140

atgatttttc ttttcagtgg ctaaaatgtt tggagcacct taacatggaa gataatgata     1200

ttccaggcat aaaaagcaat atgttcacag gattgataaa cctgaaatac ttaagtctat     1260

ccaactcctt tacaagtttg cgaactttga caaatgaaac atttgtatca cttgctcatt     1320

ctcccttaca catactcaac ctaaccaaga ataaaatctc aaaaatagag agtgatgctt     1380

tctcttggtt gggccaccta gaagtacttg acctgggcct taatgaaatt gggcaagaac     1440

tcacaggcca ggaatggaga ggtctagaaa atattttcga aatctatctt tcctacaaca     1500

agtacctgca gctgactagg aactcctttg ccttggtccc aagccttcaa cgactgatgc     1560

tccgaagggt ggcccttaaa aatgtggata gctctccttc accattccag cctcttcgta     1620

acttgaccat tctggatcta agcaacaaca acatagccaa cataaatgat gacatgttgg     1680

agggtcttga gaaactagaa attctcgatt tgcagcataa caacttagca cggctctgga     1740

aacacgcaaa ccctggtggt cccatttatt tcctaaaggg tctgtctcac ctccacatcc     1800

ttaacttgga gtccaacggc tttgacgaga tcccagttga ggtcttcaag gatttatttg     1860

aactaaagat catcgattta ggattgaata atttaaacac acttccagca tctgtcttta     1920

ataatcaggt gtctctaaag tcattgaacc ttcagaagaa tctcataaca tccgttgaga     1980

agaaggtttt cgggccagct ttcaggaacc tgactgagtt agatatgcgc tttaatccct     2040

ttgattgcac gtgtgaaagt attgcctggt ttgttaattg gattaacgag acccatacca     2100

acatccctga gctgtcaagc cactaccttt gcaacactcc acctcactat catgggttcc     2160

cagtgagact ttttgataca tcatcttgca aagacagtgc cccctttgaa ctctttttca     2220

tgatcaatac cagtatcctg ttgattttta tctttattgt acttctcatc cactttgagg     2280

gctggaggat atctttttat tggaatgttt cagtacatcg agttcttggt ttcaaagaaa     2340

tagacagaca gacagaacag tttgaatatg cagcatatat aattcatgcc tataaagata     2400

aggattgggt ctgggaacat ttctcttcaa tggaaaagga agaccaatct ctcaaatttt     2460

gtctggaaga aagggacttt gaggcgggtg tttttgaact agaagcaatt gttaacagca     2520

tcaaaagaag cagaaaaatt atttttgtta taacacacca tctattaaaa gacccattat     2580

gcaaaagatt caaggtacat catgcagttc aacaagctat tgaacaaaat ctggattcca     2640

ttatattggt tttccttgag gagattccag attataaact gaaccatgca ctctgtttgc     2700

gaagaggaat gtttaaatct cactgcatct tgaactggcc agttcagaaa gaacggatag     2760

gtgcctttcg tcataaattg caagtagcac ttggatccaa aaactctgta cattaaattt     2820

atttaaatat tcaattagca aaggagaaac tttctcaatt taaaaagttc tatggcaaat     2880

ttaagttttc cataaaggtg ttataatttg tttattcata tttgtaaatg attatattct     2940

atcacaatta catctcttct aggaaaatgt gtctccttat ttcaggccta tttttgacaa     3000

ttgacttaat tttacccaaa ataaaacata taagcacgta aaaaaaaaaa aaaaaaa        3057


<210>  66
<211>  904
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro 
1               5                   10                  15      


Phe Gly Met Leu Cys Ala Ser Ser Thr Thr Lys Cys Thr Val Ser His 
            20                  25                  30          


Glu Val Ala Asp Cys Ser His Leu Lys Leu Thr Gln Val Pro Asp Asp 
        35                  40                  45              


Leu Pro Thr Asn Ile Thr Val Leu Asn Leu Thr His Asn Gln Leu Arg 
    50                  55                  60                  


Arg Leu Pro Ala Ala Asn Phe Thr Arg Tyr Ser Gln Leu Thr Ser Leu 
65                  70                  75                  80  


Asp Val Gly Phe Asn Thr Ile Ser Lys Leu Glu Pro Glu Leu Cys Gln 
                85                  90                  95      


Lys Leu Pro Met Leu Lys Val Leu Asn Leu Gln His Asn Glu Leu Ser 
            100                 105                 110         


Gln Leu Ser Asp Lys Thr Phe Ala Phe Cys Thr Asn Leu Thr Glu Leu 
        115                 120                 125             


His Leu Met Ser Asn Ser Ile Gln Lys Ile Lys Asn Asn Pro Phe Val 
    130                 135                 140                 


Lys Gln Lys Asn Leu Ile Thr Leu Asp Leu Ser His Asn Gly Leu Ser 
145                 150                 155                 160 


Ser Thr Lys Leu Gly Thr Gln Val Gln Leu Glu Asn Leu Gln Glu Leu 
                165                 170                 175     


Leu Leu Ser Asn Asn Lys Ile Gln Ala Leu Lys Ser Glu Glu Leu Asp 
            180                 185                 190         


Ile Phe Ala Asn Ser Ser Leu Lys Lys Leu Glu Leu Ser Ser Asn Gln 
        195                 200                 205             


Ile Lys Glu Phe Ser Pro Gly Cys Phe His Ala Ile Gly Arg Leu Phe 
    210                 215                 220                 


Gly Leu Phe Leu Asn Asn Val Gln Leu Gly Pro Ser Leu Thr Glu Lys 
225                 230                 235                 240 


Leu Cys Leu Glu Leu Ala Asn Thr Ser Ile Arg Asn Leu Ser Leu Ser 
                245                 250                 255     


Asn Ser Gln Leu Ser Thr Thr Ser Asn Thr Thr Phe Leu Gly Leu Lys 
            260                 265                 270         


Trp Thr Asn Leu Thr Met Leu Asp Leu Ser Tyr Asn Asn Leu Asn Val 
        275                 280                 285             


Val Gly Asn Asp Ser Phe Ala Trp Leu Pro Gln Leu Glu Tyr Phe Phe 
    290                 295                 300                 


Leu Glu Tyr Asn Asn Ile Gln His Leu Phe Ser His Ser Leu His Gly 
305                 310                 315                 320 


Leu Phe Asn Val Arg Tyr Leu Asn Leu Lys Arg Ser Phe Thr Lys Gln 
                325                 330                 335     


Ser Ile Ser Leu Ala Ser Leu Pro Lys Ile Asp Asp Phe Ser Phe Gln 
            340                 345                 350         


Trp Leu Lys Cys Leu Glu His Leu Asn Met Glu Asp Asn Asp Ile Pro 
        355                 360                 365             


Gly Ile Lys Ser Asn Met Phe Thr Gly Leu Ile Asn Leu Lys Tyr Leu 
    370                 375                 380                 


Ser Leu Ser Asn Ser Phe Thr Ser Leu Arg Thr Leu Thr Asn Glu Thr 
385                 390                 395                 400 


Phe Val Ser Leu Ala His Ser Pro Leu His Ile Leu Asn Leu Thr Lys 
                405                 410                 415     


Asn Lys Ile Ser Lys Ile Glu Ser Asp Ala Phe Ser Trp Leu Gly His 
            420                 425                 430         


Leu Glu Val Leu Asp Leu Gly Leu Asn Glu Ile Gly Gln Glu Leu Thr 
        435                 440                 445             


Gly Gln Glu Trp Arg Gly Leu Glu Asn Ile Phe Glu Ile Tyr Leu Ser 
    450                 455                 460                 


Tyr Asn Lys Tyr Leu Gln Leu Thr Arg Asn Ser Phe Ala Leu Val Pro 
465                 470                 475                 480 


Ser Leu Gln Arg Leu Met Leu Arg Arg Val Ala Leu Lys Asn Val Asp 
                485                 490                 495     


Ser Ser Pro Ser Pro Phe Gln Pro Leu Arg Asn Leu Thr Ile Leu Asp 
            500                 505                 510         


Leu Ser Asn Asn Asn Ile Ala Asn Ile Asn Asp Asp Met Leu Glu Gly 
        515                 520                 525             


Leu Glu Lys Leu Glu Ile Leu Asp Leu Gln His Asn Asn Leu Ala Arg 
    530                 535                 540                 


Leu Trp Lys His Ala Asn Pro Gly Gly Pro Ile Tyr Phe Leu Lys Gly 
545                 550                 555                 560 


Leu Ser His Leu His Ile Leu Asn Leu Glu Ser Asn Gly Phe Asp Glu 
                565                 570                 575     


Ile Pro Val Glu Val Phe Lys Asp Leu Phe Glu Leu Lys Ile Ile Asp 
            580                 585                 590         


Leu Gly Leu Asn Asn Leu Asn Thr Leu Pro Ala Ser Val Phe Asn Asn 
        595                 600                 605             


Gln Val Ser Leu Lys Ser Leu Asn Leu Gln Lys Asn Leu Ile Thr Ser 
    610                 615                 620                 


Val Glu Lys Lys Val Phe Gly Pro Ala Phe Arg Asn Leu Thr Glu Leu 
625                 630                 635                 640 


Asp Met Arg Phe Asn Pro Phe Asp Cys Thr Cys Glu Ser Ile Ala Trp 
                645                 650                 655     


Phe Val Asn Trp Ile Asn Glu Thr His Thr Asn Ile Pro Glu Leu Ser 
            660                 665                 670         


Ser His Tyr Leu Cys Asn Thr Pro Pro His Tyr His Gly Phe Pro Val 
        675                 680                 685             


Arg Leu Phe Asp Thr Ser Ser Cys Lys Asp Ser Ala Pro Phe Glu Leu 
    690                 695                 700                 


Phe Phe Met Ile Asn Thr Ser Ile Leu Leu Ile Phe Ile Phe Ile Val 
705                 710                 715                 720 


Leu Leu Ile His Phe Glu Gly Trp Arg Ile Ser Phe Tyr Trp Asn Val 
                725                 730                 735     


Ser Val His Arg Val Leu Gly Phe Lys Glu Ile Asp Arg Gln Thr Glu 
            740                 745                 750         


Gln Phe Glu Tyr Ala Ala Tyr Ile Ile His Ala Tyr Lys Asp Lys Asp 
        755                 760                 765             


Trp Val Trp Glu His Phe Ser Ser Met Glu Lys Glu Asp Gln Ser Leu 
    770                 775                 780                 


Lys Phe Cys Leu Glu Glu Arg Asp Phe Glu Ala Gly Val Phe Glu Leu 
785                 790                 795                 800 


Glu Ala Ile Val Asn Ser Ile Lys Arg Ser Arg Lys Ile Ile Phe Val 
                805                 810                 815     


Ile Thr His His Leu Leu Lys Asp Pro Leu Cys Lys Arg Phe Lys Val 
            820                 825                 830         


His His Ala Val Gln Gln Ala Ile Glu Gln Asn Leu Asp Ser Ile Ile 
        835                 840                 845             


Leu Val Phe Leu Glu Glu Ile Pro Asp Tyr Lys Leu Asn His Ala Leu 
    850                 855                 860                 


Cys Leu Arg Arg Gly Met Phe Lys Ser His Cys Ile Leu Asn Trp Pro 
865                 870                 875                 880 


Val Gln Lys Glu Arg Ile Gly Ala Phe Arg His Lys Leu Gln Val Ala 
                885                 890                 895     


Leu Gly Ser Lys Asn Ser Val His 
            900                 


<210>  67
<211>  3220
<212>  DNA
<213>  Homo sapiens

<400>  67
aaactttttt ccctggctct gccctgggtt tccccttgaa gggatttccc tccgcctctg       60

caacaagacc ctttataaag cacagacttt ctatttcact ccgcggtatc tgcatcgggc      120

ctcactggct tcaggagctg aataccctcc caggcacaca caggtgggac acaaataagg      180

gttttggaac cactattttc tcatcacgac agcaacttaa aatgcctggg aagatggtcg      240

tgatccttgg agcctcaaat atactttgga taatgtttgc agcttctcaa gcttttaaaa      300

tcgagaccac cccagaatct agatatcttg ctcagattgg tgactccgtc tcattgactt      360

gcagcaccac aggctgtgag tccccatttt tctcttggag aacccagata gatagtccac      420

tgaatgggaa ggtgacgaat gaggggacca catctacgct gacaatgaat cctgttagtt      480

ttgggaacga acactcttac ctgtgcacag caacttgtga atctaggaaa ttggaaaaag      540

gaatccaggt ggagatctac tcttttccta aggatccaga gattcatttg agtggccctc      600

tggaggctgg gaagccgatc acagtcaagt gttcagttgc tgatgtatac ccatttgaca      660

ggctggagat agacttactg aaaggagatc atctcatgaa gagtcaggaa tttctggagg      720

atgcagacag gaagtccctg gaaaccaaga gtttggaagt aacctttact cctgtcattg      780

aggatattgg aaaagttctt gtttgccgag ctaaattaca cattgatgaa atggattctg      840

tgcccacagt aaggcaggct gtaaaagaat tgcaagtcta catatcaccc aagaatacag      900

ttatttctgt gaatccatcc acaaagctgc aagaaggtgg ctctgtgacc atgacctgtt      960

ccagcgaggg tctaccagct ccagagattt tctggagtaa gaaattagat aatgggaatc     1020

tacagcacct ttctggaaat gcaactctca ccttaattgc tatgaggatg gaagattctg     1080

gaatttatgt gtgtgaagga gttaatttga ttgggaaaaa cagaaaagag gtggaattaa     1140

ttgttcaaga gaaaccattt actgttgaga tctcccctgg accccggatt gctgctcaga     1200

ttggagactc agtcatgttg acatgtagtg tcatgggctg tgaatcccca tctttctcct     1260

ggagaaccca gatagacagc cctctgagcg ggaaggtgag gagtgagggg accaattcca     1320

cgctgaccct gagccctgtg agttttgaga acgaacactc ttatctgtgc acagtgactt     1380

gtggacataa gaaactggaa aagggaatcc aggtggagct ctactcattc cctagagatc     1440

cagaaatcga gatgagtggt ggcctcgtga atgggagctc tgtcactgta agctgcaagg     1500

ttcctagcgt gtaccccctt gaccggctgg agattgaatt acttaagggg gagactattc     1560

tggagaatat agagtttttg gaggatacgg atatgaaatc tctagagaac aaaagtttgg     1620

aaatgacctt catccctacc attgaagata ctggaaaagc tcttgtttgt caggctaagt     1680

tacatattga tgacatggaa ttcgaaccca aacaaaggca gagtacgcaa acactttatg     1740

tcaatgttgc ccccagagat acaaccgtct tggtcagccc ttcctccatc ctggaggaag     1800

gcagttctgt gaatatgaca tgcttgagcc agggctttcc tgctccgaaa atcctgtgga     1860

gcaggcagct ccctaacggg gagctacagc ctctttctga gaatgcaact ctcaccttaa     1920

tttctacaaa aatggaagat tctggggttt atttatgtga aggaattaac caggctggaa     1980

gaagcagaaa ggaagtggaa ttaattatcc aagttactcc aaaagacata aaacttacag     2040

cttttccttc tgagagtgtc aaagaaggag acactgtcat catctcttgt acatgtggaa     2100

atgttccaga aacatggata atcctgaaga aaaaagcgga gacaggagac acagtactaa     2160

aatctataga tggcgcctat accatccgaa aggcccagtt gaaggatgcg ggagtatatg     2220

aatgtgaatc taaaaacaaa gttggctcac aattaagaag tttaacactt gatgttcaag     2280

gaagagaaaa caacaaagac tatttttctc ctgagcttct cgtgctctat tttgcatcct     2340

ccttaataat acctgccatt ggaatgataa tttactttgc aagaaaagcc aacatgaagg     2400

ggtcatatag tcttgtagaa gcacagaagt caaaagtgta gctaatgctt gatatgttca     2460

actggagaca ctatttatct gtgcaaatcc ttgatactgc tcatcattcc ttgagaaaaa     2520

caatgagctg agaggcagac ttccctgaat gtattgaact tggaaagaaa tgcccatcta     2580

tgtcccttgc tgtgagcaag aagtcaaagt aaaacttgct gcctgaagaa cagtaactgc     2640

catcaagatg agagaactgg aggagttcct tgatctgtat atacaataac ataatttgta     2700

catatgtaaa ataaaattat gccatagcaa gattgcttaa aatagcaaca ctctatattt     2760

agattgttaa aataactagt gttgcttgga ctattataat ttaatgcatg ttaggaaaat     2820

ttcacattaa tatttgctga cagctgacct ttgtcatctt tcttctattt tattcccttt     2880

cacaaaattt tattcctata tagtttattg acaataattt caggttttgt aaagatgccg     2940

ggttttatat ttttatagac aaataataag caaagggagc actgggttga ctttcaggta     3000

ctaaatacct caacctatgg tataatggtt gactgggttt ctctgtatag tactggcatg     3060

gtacggagat gtttcacgaa gtttgttcat cagactcctg tgcaactttc ccaatgtggc     3120

ctaaaaatgc aacttctttt tattttcttt tgtaaatgtt taggtttttt tgtatagtaa     3180

agtgataatt tctggaatta gaaaaaaaaa aaaaaaaaaa                           3220


<210>  68
<211>  739
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Pro Gly Lys Met Val Val Ile Leu Gly Ala Ser Asn Ile Leu Trp 
1               5                   10                  15      


Ile Met Phe Ala Ala Ser Gln Ala Phe Lys Ile Glu Thr Thr Pro Glu 
            20                  25                  30          


Ser Arg Tyr Leu Ala Gln Ile Gly Asp Ser Val Ser Leu Thr Cys Ser 
        35                  40                  45              


Thr Thr Gly Cys Glu Ser Pro Phe Phe Ser Trp Arg Thr Gln Ile Asp 
    50                  55                  60                  


Ser Pro Leu Asn Gly Lys Val Thr Asn Glu Gly Thr Thr Ser Thr Leu 
65                  70                  75                  80  


Thr Met Asn Pro Val Ser Phe Gly Asn Glu His Ser Tyr Leu Cys Thr 
                85                  90                  95      


Ala Thr Cys Glu Ser Arg Lys Leu Glu Lys Gly Ile Gln Val Glu Ile 
            100                 105                 110         


Tyr Ser Phe Pro Lys Asp Pro Glu Ile His Leu Ser Gly Pro Leu Glu 
        115                 120                 125             


Ala Gly Lys Pro Ile Thr Val Lys Cys Ser Val Ala Asp Val Tyr Pro 
    130                 135                 140                 


Phe Asp Arg Leu Glu Ile Asp Leu Leu Lys Gly Asp His Leu Met Lys 
145                 150                 155                 160 


Ser Gln Glu Phe Leu Glu Asp Ala Asp Arg Lys Ser Leu Glu Thr Lys 
                165                 170                 175     


Ser Leu Glu Val Thr Phe Thr Pro Val Ile Glu Asp Ile Gly Lys Val 
            180                 185                 190         


Leu Val Cys Arg Ala Lys Leu His Ile Asp Glu Met Asp Ser Val Pro 
        195                 200                 205             


Thr Val Arg Gln Ala Val Lys Glu Leu Gln Val Tyr Ile Ser Pro Lys 
    210                 215                 220                 


Asn Thr Val Ile Ser Val Asn Pro Ser Thr Lys Leu Gln Glu Gly Gly 
225                 230                 235                 240 


Ser Val Thr Met Thr Cys Ser Ser Glu Gly Leu Pro Ala Pro Glu Ile 
                245                 250                 255     


Phe Trp Ser Lys Lys Leu Asp Asn Gly Asn Leu Gln His Leu Ser Gly 
            260                 265                 270         


Asn Ala Thr Leu Thr Leu Ile Ala Met Arg Met Glu Asp Ser Gly Ile 
        275                 280                 285             


Tyr Val Cys Glu Gly Val Asn Leu Ile Gly Lys Asn Arg Lys Glu Val 
    290                 295                 300                 


Glu Leu Ile Val Gln Glu Lys Pro Phe Thr Val Glu Ile Ser Pro Gly 
305                 310                 315                 320 


Pro Arg Ile Ala Ala Gln Ile Gly Asp Ser Val Met Leu Thr Cys Ser 
                325                 330                 335     


Val Met Gly Cys Glu Ser Pro Ser Phe Ser Trp Arg Thr Gln Ile Asp 
            340                 345                 350         


Ser Pro Leu Ser Gly Lys Val Arg Ser Glu Gly Thr Asn Ser Thr Leu 
        355                 360                 365             


Thr Leu Ser Pro Val Ser Phe Glu Asn Glu His Ser Tyr Leu Cys Thr 
    370                 375                 380                 


Val Thr Cys Gly His Lys Lys Leu Glu Lys Gly Ile Gln Val Glu Leu 
385                 390                 395                 400 


Tyr Ser Phe Pro Arg Asp Pro Glu Ile Glu Met Ser Gly Gly Leu Val 
                405                 410                 415     


Asn Gly Ser Ser Val Thr Val Ser Cys Lys Val Pro Ser Val Tyr Pro 
            420                 425                 430         


Leu Asp Arg Leu Glu Ile Glu Leu Leu Lys Gly Glu Thr Ile Leu Glu 
        435                 440                 445             


Asn Ile Glu Phe Leu Glu Asp Thr Asp Met Lys Ser Leu Glu Asn Lys 
    450                 455                 460                 


Ser Leu Glu Met Thr Phe Ile Pro Thr Ile Glu Asp Thr Gly Lys Ala 
465                 470                 475                 480 


Leu Val Cys Gln Ala Lys Leu His Ile Asp Asp Met Glu Phe Glu Pro 
                485                 490                 495     


Lys Gln Arg Gln Ser Thr Gln Thr Leu Tyr Val Asn Val Ala Pro Arg 
            500                 505                 510         


Asp Thr Thr Val Leu Val Ser Pro Ser Ser Ile Leu Glu Glu Gly Ser 
        515                 520                 525             


Ser Val Asn Met Thr Cys Leu Ser Gln Gly Phe Pro Ala Pro Lys Ile 
    530                 535                 540                 


Leu Trp Ser Arg Gln Leu Pro Asn Gly Glu Leu Gln Pro Leu Ser Glu 
545                 550                 555                 560 


Asn Ala Thr Leu Thr Leu Ile Ser Thr Lys Met Glu Asp Ser Gly Val 
                565                 570                 575     


Tyr Leu Cys Glu Gly Ile Asn Gln Ala Gly Arg Ser Arg Lys Glu Val 
            580                 585                 590         


Glu Leu Ile Ile Gln Val Thr Pro Lys Asp Ile Lys Leu Thr Ala Phe 
        595                 600                 605             


Pro Ser Glu Ser Val Lys Glu Gly Asp Thr Val Ile Ile Ser Cys Thr 
    610                 615                 620                 


Cys Gly Asn Val Pro Glu Thr Trp Ile Ile Leu Lys Lys Lys Ala Glu 
625                 630                 635                 640 


Thr Gly Asp Thr Val Leu Lys Ser Ile Asp Gly Ala Tyr Thr Ile Arg 
                645                 650                 655     


Lys Ala Gln Leu Lys Asp Ala Gly Val Tyr Glu Cys Glu Ser Lys Asn 
            660                 665                 670         


Lys Val Gly Ser Gln Leu Arg Ser Leu Thr Leu Asp Val Gln Gly Arg 
        675                 680                 685             


Glu Asn Asn Lys Asp Tyr Phe Ser Pro Glu Leu Leu Val Leu Tyr Phe 
    690                 695                 700                 


Ala Ser Ser Leu Ile Ile Pro Ala Ile Gly Met Ile Ile Tyr Phe Ala 
705                 710                 715                 720 


Arg Lys Ala Asn Met Lys Gly Ser Tyr Ser Leu Val Glu Ala Gln Lys 
                725                 730                 735     


Ser Lys Val 
            


