                         SEQUENCE LISTING

<110>  E.I. du Pont de Nemours & Company, Inc.
       Nagy, Kevin
 
<120>  ENZYMATIC HYDROLYSIS OF DISACCHARIDES AND OLIGOSACCHARIDES USING 
       ALPHA-GLUCOSIDASE ENZYMES

<130>  CL6220

<150>  US 61/945,233
<151>  2014-02-27

<150>  US 61/945,241
<151>  2014-02-27

<150>  US 62/004,305
<151>  2014-05-29

<150>  US 62/004,314
<151>  2014-05-29

<150>  US 62/004,300
<151>  2014-05-29

<150>  US 62/004,312
<151>  2014-05-29

<150>  US 62/004,308
<151>  2014-05-29

<150>  US 62/004,290
<151>  2014-05-29

<160>  47    

<170>  PatentIn version 3.5

<210>  1
<211>  965
<212>  PRT
<213>  Aspergillus niger

<400>  1

Ser Gln Ser Leu Leu Ser Thr Thr Ala Pro Ser Gln Pro Gln Phe Thr 
1               5                   10                  15      


Ile Pro Ala Ser Ala Asp Val Gly Ala Gln Leu Ile Ala Asn Ile Asp 
            20                  25                  30          


Asp Pro Gln Ala Ala Asp Ala Gln Ser Val Cys Pro Gly Tyr Lys Ala 
        35                  40                  45              


Ser Lys Val Gln His Asn Ser Arg Gly Phe Thr Ala Ser Leu Gln Leu 
    50                  55                  60                  


Ala Gly Arg Pro Cys Asn Val Tyr Gly Thr Asp Val Glu Ser Leu Thr 
65                  70                  75                  80  


Leu Ser Val Glu Tyr Gln Asp Ser Asp Arg Leu Asn Ile Gln Ile Leu 
                85                  90                  95      


Pro Thr His Val Asp Ser Thr Asn Ala Ser Trp Tyr Phe Leu Ser Glu 
            100                 105                 110         


Asn Leu Val Pro Arg Pro Lys Ala Ser Leu Asn Ala Ser Val Ser Gln 
        115                 120                 125             


Ser Asp Leu Phe Val Ser Trp Ser Asn Glu Pro Ser Phe Asn Phe Lys 
    130                 135                 140                 


Val Ile Arg Lys Ala Thr Gly Asp Ala Leu Phe Ser Thr Glu Gly Thr 
145                 150                 155                 160 


Val Leu Val Tyr Glu Asn Gln Phe Ile Glu Phe Val Thr Ala Leu Pro 
                165                 170                 175     


Glu Glu Tyr Asn Leu Tyr Gly Leu Gly Glu His Ile Thr Gln Phe Arg 
            180                 185                 190         


Leu Gln Arg Asn Ala Asn Leu Thr Ile Tyr Pro Ser Asp Asp Gly Thr 
        195                 200                 205             


Pro Ile Asp Gln Asn Leu Tyr Gly Gln His Pro Phe Tyr Leu Asp Thr 
    210                 215                 220                 


Arg Tyr Tyr Lys Gly Asp Arg Gln Asn Gly Ser Tyr Ile Pro Val Lys 
225                 230                 235                 240 


Ser Ser Glu Ala Asp Ala Ser Gln Asp Tyr Ile Ser Leu Ser His Gly 
                245                 250                 255     


Val Phe Leu Arg Asn Ser His Gly Leu Glu Ile Leu Leu Arg Ser Gln 
            260                 265                 270         


Lys Leu Ile Trp Arg Thr Leu Gly Gly Gly Ile Asp Leu Thr Phe Tyr 
        275                 280                 285             


Ser Gly Pro Ala Pro Ala Asp Val Thr Arg Gln Tyr Leu Thr Ser Thr 
    290                 295                 300                 


Val Gly Leu Pro Ala Met Gln Gln Tyr Asn Thr Leu Gly Phe His Gln 
305                 310                 315                 320 


Cys Arg Trp Gly Tyr Asn Asn Trp Ser Asp Leu Ala Asp Val Val Ala 
                325                 330                 335     


Asn Phe Glu Lys Phe Glu Ile Pro Leu Glu Tyr Ile Trp Thr Asp Ile 
            340                 345                 350         


Asp Tyr Met His Gly Tyr Arg Asn Phe Asp Asn Asp Gln His Arg Phe 
        355                 360                 365             


Ser Tyr Ser Glu Gly Asp Glu Phe Leu Ser Lys Leu His Glu Ser Gly 
    370                 375                 380                 


Arg Tyr Tyr Val Pro Ile Val Asp Ala Ala Leu Tyr Ile Pro Asn Pro 
385                 390                 395                 400 


Glu Asn Ala Ser Asp Ala Tyr Ala Thr Tyr Asp Arg Gly Ala Ala Asp 
                405                 410                 415     


Asp Val Phe Leu Lys Asn Pro Asp Gly Ser Leu Tyr Ile Gly Ala Val 
            420                 425                 430         


Trp Pro Gly Tyr Thr Val Phe Pro Asp Trp His His Pro Lys Ala Val 
        435                 440                 445             


Asp Phe Trp Ala Asn Glu Leu Val Ile Trp Ser Lys Lys Val Ala Phe 
    450                 455                 460                 


Asp Gly Val Trp Tyr Asp Met Ser Glu Val Ser Ser Phe Cys Val Gly 
465                 470                 475                 480 


Ser Cys Gly Thr Gly Asn Leu Thr Leu Asn Pro Ala His Pro Ser Phe 
                485                 490                 495     


Leu Leu Pro Gly Glu Pro Gly Asp Ile Ile Tyr Asp Tyr Pro Glu Ala 
            500                 505                 510         


Phe Asn Ile Thr Asn Ala Thr Glu Ala Ala Ser Ala Ser Ala Gly Ala 
        515                 520                 525             


Ser Ser Gln Ala Ala Ala Thr Ala Thr Thr Thr Ser Thr Ser Val Ser 
    530                 535                 540                 


Tyr Leu Arg Thr Thr Pro Thr Pro Gly Val Arg Asn Val Glu His Pro 
545                 550                 555                 560 


Pro Tyr Val Ile Asn His Asp Gln Glu Gly His Asp Leu Ser Val His 
                565                 570                 575     


Ala Val Ser Pro Asn Ala Thr His Val Asp Gly Val Glu Glu Tyr Asp 
            580                 585                 590         


Val His Gly Leu Tyr Gly His Gln Gly Leu Asn Ala Thr Tyr Gln Gly 
        595                 600                 605             


Leu Leu Glu Val Trp Ser His Lys Arg Arg Pro Phe Ile Ile Gly Arg 
    610                 615                 620                 


Ser Thr Phe Ala Gly Ser Gly Lys Trp Ala Gly His Trp Gly Gly Asp 
625                 630                 635                 640 


Asn Tyr Ser Lys Trp Trp Ser Met Tyr Tyr Ser Ile Ser Gln Ala Leu 
                645                 650                 655     


Ser Phe Ser Leu Phe Asp Ile Pro Met Phe Gly Ala Asp Thr Cys Gly 
            660                 665                 670         


Phe Asn Gly Asn Ser Asp Glu Glu Leu Cys Asn Arg Trp Met Gln Leu 
        675                 680                 685             


Ser Ala Phe Phe Pro Phe Tyr Arg Asn His Asn Glu Leu Ser Thr Ile 
    690                 695                 700                 


Pro Gln Glu Pro Tyr Arg Trp Ala Ser Val Ile Glu Ala Thr Lys Ser 
705                 710                 715                 720 


Ala Met Arg Ile Arg Tyr Ala Ile Leu Pro Tyr Phe Tyr Thr Leu Phe 
                725                 730                 735     


Asp Leu Ala His Thr Thr Gly Ser Thr Val Met Arg Ala Leu Ser Trp 
            740                 745                 750         


Glu Phe Pro Asn Asp Pro Thr Leu Ala Ala Val Glu Thr Gln Phe Met 
        755                 760                 765             


Val Gly Pro Ala Ile Met Val Val Pro Val Leu Glu Pro Leu Val Asn 
    770                 775                 780                 


Thr Val Lys Gly Val Phe Pro Gly Val Gly His Gly Glu Val Trp Tyr 
785                 790                 795                 800 


Asp Trp Tyr Thr Gln Ala Ala Val Asp Ala Lys Pro Gly Val Asn Thr 
                805                 810                 815     


Thr Ile Ser Ala Pro Leu Gly His Ile Pro Val Tyr Val Arg Gly Gly 
            820                 825                 830         


Asn Ile Leu Pro Met Gln Glu Pro Ala Leu Thr Thr Arg Glu Ala Arg 
        835                 840                 845             


Gln Thr Pro Trp Ala Leu Leu Ala Ala Leu Gly Ser Asn Gly Thr Ala 
    850                 855                 860                 


Ser Gly Gln Leu Tyr Leu Asp Asp Gly Glu Ser Ile Tyr Pro Asn Ala 
865                 870                 875                 880 


Thr Leu His Val Asp Phe Thr Ala Ser Arg Ser Ser Leu Arg Ser Ser 
                885                 890                 895     


Ala Gln Gly Arg Trp Lys Glu Arg Asn Pro Leu Ala Asn Val Thr Val 
            900                 905                 910         


Leu Gly Val Asn Lys Glu Pro Ser Ala Val Thr Leu Asn Gly Gln Ala 
        915                 920                 925             


Val Phe Pro Gly Ser Val Thr Tyr Asn Ser Thr Ser Gln Val Leu Phe 
    930                 935                 940                 


Val Gly Gly Leu Gln Asn Leu Thr Lys Gly Gly Ala Trp Ala Glu Asn 
945                 950                 955                 960 


Trp Val Leu Glu Trp 
                965 


<210>  2
<211>  599
<212>  PRT
<213>  Trichoderma reesei

<400>  2

Ser Val Asp Asp Phe Ile Ser Thr Glu Thr Pro Ile Ala Leu Asn Asn 
1               5                   10                  15      


Leu Leu Cys Asn Val Gly Pro Asp Gly Cys Arg Ala Phe Gly Thr Ser 
            20                  25                  30          


Ala Gly Ala Val Ile Ala Ser Pro Ser Thr Ile Asp Pro Asp Tyr Tyr 
        35                  40                  45              


Tyr Met Trp Thr Arg Asp Ser Ala Leu Val Phe Lys Asn Leu Ile Asp 
    50                  55                  60                  


Arg Phe Thr Glu Thr Tyr Asp Ala Gly Leu Gln Arg Arg Ile Glu Gln 
65                  70                  75                  80  


Tyr Ile Thr Ala Gln Val Thr Leu Gln Gly Leu Ser Asn Pro Ser Gly 
                85                  90                  95      


Ser Leu Ala Asp Gly Ser Gly Leu Gly Glu Pro Lys Phe Glu Leu Thr 
            100                 105                 110         


Leu Lys Pro Phe Thr Gly Asn Trp Gly Arg Pro Gln Arg Asp Gly Pro 
        115                 120                 125             


Ala Leu Arg Ala Ile Ala Leu Ile Gly Tyr Ser Lys Trp Leu Ile Asn 
    130                 135                 140                 


Asn Asn Tyr Gln Ser Thr Val Ser Asn Val Ile Trp Pro Ile Val Arg 
145                 150                 155                 160 


Asn Asp Leu Asn Tyr Val Ala Gln Tyr Trp Asn Gln Thr Gly Phe Asp 
                165                 170                 175     


Leu Trp Glu Glu Val Asn Gly Ser Ser Phe Phe Thr Val Ala Asn Gln 
            180                 185                 190         


His Arg Ala Leu Val Glu Gly Ala Thr Leu Ala Ala Thr Leu Gly Gln 
        195                 200                 205             


Ser Gly Ser Ala Tyr Ser Ser Val Ala Pro Gln Val Leu Cys Phe Leu 
    210                 215                 220                 


Gln Arg Phe Trp Val Ser Ser Gly Gly Tyr Val Asp Ser Asn Ile Asn 
225                 230                 235                 240 


Thr Asn Glu Gly Arg Thr Gly Lys Asp Val Asn Ser Val Leu Thr Ser 
                245                 250                 255     


Ile His Thr Phe Asp Pro Asn Leu Gly Cys Asp Ala Gly Thr Phe Gln 
            260                 265                 270         


Pro Cys Ser Asp Lys Ala Leu Ser Asn Leu Lys Val Val Val Asp Ser 
        275                 280                 285             


Phe Arg Ser Ile Tyr Gly Val Asn Lys Gly Ile Pro Ala Gly Ala Ala 
    290                 295                 300                 


Val Ala Ile Gly Arg Tyr Ala Glu Asp Val Tyr Tyr Asn Gly Asn Pro 
305                 310                 315                 320 


Trp Tyr Leu Ala Thr Phe Ala Ala Ala Glu Gln Leu Tyr Asp Ala Ile 
                325                 330                 335     


Tyr Val Trp Lys Lys Thr Gly Ser Ile Thr Val Thr Ala Thr Ser Leu 
            340                 345                 350         


Ala Phe Phe Gln Glu Leu Val Pro Gly Val Thr Ala Gly Thr Tyr Ser 
        355                 360                 365             


Ser Ser Ser Ser Thr Phe Thr Asn Ile Ile Asn Ala Val Ser Thr Tyr 
    370                 375                 380                 


Ala Asp Gly Phe Leu Ser Glu Ala Ala Lys Tyr Val Pro Ala Asp Gly 
385                 390                 395                 400 


Ser Leu Ala Glu Gln Phe Asp Arg Asn Ser Gly Thr Pro Leu Ser Ala 
                405                 410                 415     


Leu His Leu Thr Trp Ser Tyr Ala Ser Phe Leu Thr Ala Thr Ala Arg 
            420                 425                 430         


Arg Ala Gly Ile Val Pro Pro Ser Trp Ala Asn Ser Ser Ala Ser Thr 
        435                 440                 445             


Ile Pro Ser Thr Cys Ser Gly Ala Ser Val Val Gly Ser Tyr Ser Arg 
    450                 455                 460                 


Pro Thr Ala Thr Ser Phe Pro Pro Ser Gln Thr Pro Lys Pro Gly Val 
465                 470                 475                 480 


Pro Ser Gly Thr Pro Tyr Thr Pro Leu Pro Cys Ala Thr Pro Thr Ser 
                485                 490                 495     


Val Ala Val Thr Phe His Glu Leu Val Ser Thr Gln Phe Gly Gln Thr 
            500                 505                 510         


Val Lys Val Ala Gly Asn Ala Ala Ala Leu Gly Asn Trp Ser Thr Ser 
        515                 520                 525             


Ala Ala Val Ala Leu Asp Ala Val Asn Tyr Ala Asp Asn His Pro Leu 
    530                 535                 540                 


Trp Ile Gly Thr Val Asn Leu Glu Ala Gly Asp Val Val Glu Tyr Lys 
545                 550                 555                 560 


Tyr Ile Asn Val Gly Gln Asp Gly Ser Val Thr Trp Glu Ser Asp Pro 
                565                 570                 575     


Asn His Thr Tyr Thr Val Pro Ala Val Ala Cys Val Thr Gln Val Val 
            580                 585                 590         


Lys Glu Asp Thr Trp Gln Ser 
        595                 


<210>  3
<211>  1477
<212>  PRT
<213>  Streptococcus salivarius

<400>  3

Met Asp Glu Thr Gln Asp Lys Thr Val Thr Gln Ser Asn Ser Gly Thr 
1               5                   10                  15      


Thr Ala Ser Leu Val Thr Ser Pro Glu Ala Thr Lys Glu Ala Asp Lys 
            20                  25                  30          


Arg Thr Asn Thr Lys Glu Ala Asp Val Leu Thr Pro Ala Lys Glu Thr 
        35                  40                  45              


Asn Ala Val Glu Thr Ala Thr Thr Thr Asn Thr Gln Ala Thr Ala Glu 
    50                  55                  60                  


Ala Ala Thr Thr Ala Thr Thr Ala Asp Val Ala Val Ala Ala Val Pro 
65                  70                  75                  80  


Asn Lys Glu Ala Val Val Thr Thr Asp Ala Pro Ala Val Thr Thr Glu 
                85                  90                  95      


Lys Ala Glu Glu Gln Pro Ala Thr Val Lys Ala Glu Val Val Asn Thr 
            100                 105                 110         


Glu Val Lys Ala Pro Glu Ala Ala Leu Lys Asp Ser Glu Val Glu Ala 
        115                 120                 125             


Ala Leu Ser Leu Lys Asn Ile Lys Asn Ile Asp Gly Lys Tyr Tyr Tyr 
    130                 135                 140                 


Val Asn Glu Asp Gly Ser His Lys Glu Asn Phe Ala Ile Thr Val Asn 
145                 150                 155                 160 


Gly Gln Leu Leu Tyr Phe Gly Lys Asp Gly Ala Leu Thr Ser Ser Ser 
                165                 170                 175     


Thr Tyr Ser Phe Thr Pro Gly Thr Thr Asn Ile Val Asp Gly Phe Ser 
            180                 185                 190         


Ile Asn Asn Arg Ala Tyr Asp Ser Ser Glu Ala Ser Phe Glu Leu Ile 
        195                 200                 205             


Asp Gly Tyr Leu Thr Ala Asp Ser Trp Tyr Arg Pro Ala Ser Ile Ile 
    210                 215                 220                 


Lys Asp Gly Val Thr Trp Gln Ala Ser Thr Ala Glu Asp Phe Arg Pro 
225                 230                 235                 240 


Leu Leu Met Ala Trp Trp Pro Asn Val Asp Thr Gln Val Asn Tyr Leu 
                245                 250                 255     


Asn Tyr Met Ser Lys Val Phe Asn Leu Asp Ala Lys Tyr Ser Ser Thr 
            260                 265                 270         


Asp Lys Gln Glu Thr Leu Lys Val Ala Ala Lys Asp Ile Gln Ile Lys 
        275                 280                 285             


Ile Glu Gln Lys Ile Gln Ala Glu Lys Ser Thr Gln Trp Leu Arg Glu 
    290                 295                 300                 


Thr Ile Ser Ala Phe Val Lys Thr Gln Pro Gln Trp Asn Lys Glu Thr 
305                 310                 315                 320 


Glu Asn Tyr Ser Lys Gly Gly Gly Glu Asp His Leu Gln Gly Gly Ala 
                325                 330                 335     


Leu Leu Tyr Val Asn Asp Ser Arg Thr Pro Trp Ala Asn Ser Asp Tyr 
            340                 345                 350         


Arg Arg Leu Asn Arg Thr Ala Thr Asn Gln Thr Gly Thr Ile Asp Lys 
        355                 360                 365             


Ser Ile Leu Asp Glu Gln Ser Asp Pro Asn His Met Gly Gly Phe Asp 
    370                 375                 380                 


Phe Leu Leu Ala Asn Asp Val Asp Leu Ser Asn Pro Val Val Gln Ala 
385                 390                 395                 400 


Glu Gln Leu Asn Gln Ile His Tyr Leu Met Asn Trp Gly Ser Ile Val 
                405                 410                 415     


Met Gly Asp Lys Asp Ala Asn Phe Asp Gly Ile Arg Val Asp Ala Val 
            420                 425                 430         


Asp Asn Val Asp Ala Asp Met Leu Gln Leu Tyr Thr Asn Tyr Phe Arg 
        435                 440                 445             


Glu Tyr Tyr Gly Val Asn Lys Ser Glu Ala Asn Ala Leu Ala His Ile 
    450                 455                 460                 


Ser Val Leu Glu Ala Trp Ser Leu Asn Asp Asn His Tyr Asn Asp Lys 
465                 470                 475                 480 


Thr Asp Gly Ala Ala Leu Ala Met Glu Asn Lys Gln Arg Leu Ala Leu 
                485                 490                 495     


Leu Phe Ser Leu Ala Lys Pro Ile Lys Glu Arg Thr Pro Ala Val Ser 
            500                 505                 510         


Pro Leu Tyr Asn Asn Thr Phe Asn Thr Thr Gln Arg Asp Glu Lys Thr 
        515                 520                 525             


Asp Trp Ile Asn Lys Asp Gly Ser Lys Ala Tyr Asn Glu Asp Gly Thr 
    530                 535                 540                 


Val Lys Gln Ser Thr Ile Gly Lys Tyr Asn Glu Lys Tyr Gly Asp Ala 
545                 550                 555                 560 


Ser Gly Asn Tyr Val Phe Ile Arg Ala His Asp Asn Asn Val Gln Asp 
                565                 570                 575     


Ile Ile Ala Glu Ile Ile Lys Lys Glu Ile Asn Pro Lys Ser Asp Gly 
            580                 585                 590         


Phe Thr Ile Thr Asp Ala Glu Met Lys Gln Ala Phe Glu Ile Tyr Asn 
        595                 600                 605             


Lys Asp Met Leu Ser Ser Asp Lys Lys Tyr Thr Leu Asn Asn Ile Pro 
    610                 615                 620                 


Ala Ala Tyr Ala Val Met Leu Gln Asn Met Glu Thr Ile Thr Arg Val 
625                 630                 635                 640 


Tyr Tyr Gly Asp Leu Tyr Thr Asp Asp Gly His Tyr Met Glu Thr Lys 
                645                 650                 655     


Ser Pro Tyr Tyr Asp Thr Ile Val Asn Leu Met Lys Ser Arg Ile Lys 
            660                 665                 670         


Tyr Val Ser Gly Gly Gln Ala Gln Arg Ser Tyr Trp Leu Pro Thr Asp 
        675                 680                 685             


Gly Lys Met Asp Asn Ser Asp Val Glu Leu Tyr Arg Thr Asn Glu Val 
    690                 695                 700                 


Tyr Thr Ser Val Arg Tyr Gly Lys Asp Ile Met Thr Ala Asn Asp Thr 
705                 710                 715                 720 


Glu Gly Ser Lys Tyr Ser Arg Thr Ser Gly Gln Val Thr Leu Val Ala 
                725                 730                 735     


Asn Asn Pro Lys Leu Asn Leu Asp Gln Ser Ala Lys Leu Asn Val Glu 
            740                 745                 750         


Met Gly Lys Ile His Ala Asn Gln Lys Tyr Arg Ala Leu Ile Val Gly 
        755                 760                 765             


Thr Ala Asp Gly Ile Lys Asn Phe Thr Ser Asp Ala Asp Ala Ile Ala 
    770                 775                 780                 


Ala Gly Tyr Val Lys Glu Thr Asp Ser Asn Gly Val Leu Thr Phe Gly 
785                 790                 795                 800 


Ala Asn Asp Ile Lys Gly Tyr Glu Thr Phe Asp Met Ser Gly Phe Val 
                805                 810                 815     


Ala Val Trp Val Pro Val Gly Ala Ser Asp Asn Gln Asp Ile Arg Val 
            820                 825                 830         


Ala Pro Ser Thr Glu Ala Lys Lys Glu Gly Glu Leu Thr Leu Lys Ala 
        835                 840                 845             


Thr Glu Ala Tyr Asp Ser Gln Leu Ile Tyr Glu Gly Phe Ser Asn Phe 
    850                 855                 860                 


Gln Thr Ile Pro Asp Gly Ser Asp Pro Ser Val Tyr Thr Asn Arg Lys 
865                 870                 875                 880 


Ile Ala Glu Asn Val Asp Leu Phe Lys Ser Trp Gly Val Thr Ser Phe 
                885                 890                 895     


Glu Met Ala Pro Gln Phe Val Ser Ala Asp Asp Gly Thr Phe Leu Asp 
            900                 905                 910         


Ser Val Ile Gln Asn Gly Tyr Ala Phe Ala Asp Arg Tyr Asp Leu Ala 
        915                 920                 925             


Met Ser Lys Asn Asn Lys Tyr Gly Ser Lys Glu Asp Leu Arg Asp Ala 
    930                 935                 940                 


Leu Lys Ala Leu His Lys Ala Gly Ile Gln Ala Ile Ala Asp Trp Val 
945                 950                 955                 960 


Pro Asp Gln Ile Tyr Gln Leu Pro Gly Lys Glu Val Val Thr Ala Thr 
                965                 970                 975     


Arg Thr Asp Gly Ala Gly Arg Lys Ile Ala Asp Ala Ile Ile Asp His 
            980                 985                 990         


Ser Leu Tyr Val Ala Asn Ser Lys  Ser Ser Gly Lys Asp  Tyr Gln Ala 
        995                 1000                 1005             


Lys Tyr  Gly Gly Glu Phe Leu  Ala Glu Leu Lys Ala  Lys Tyr Pro 
    1010                 1015                 1020             


Glu Met  Phe Lys Val Asn Met  Ile Ser Thr Gly Lys  Pro Ile Asp 
    1025                 1030                 1035             


Asp Ser  Val Lys Leu Lys Gln  Trp Lys Ala Glu Tyr  Phe Asn Gly 
    1040                 1045                 1050             


Thr Asn  Val Leu Glu Arg Gly  Val Gly Tyr Val Leu  Ser Asp Glu 
    1055                 1060                 1065             


Ala Thr  Gly Lys Tyr Phe Thr  Val Thr Lys Glu Gly  Asn Phe Ile 
    1070                 1075                 1080             


Pro Leu  Gln Leu Thr Gly Lys  Glu Lys Val Ile Thr  Gly Phe Ser 
    1085                 1090                 1095             


Ser Asp  Gly Lys Gly Ile Thr  Tyr Phe Gly Thr Ser  Gly Thr Gln 
    1100                 1105                 1110             


Ala Lys  Ser Ala Phe Val Thr  Phe Asn Gly Asn Thr  Tyr Tyr Phe 
    1115                 1120                 1125             


Asp Ala  Arg Gly His Met Val  Thr Asn Ser Glu Tyr  Ser Pro Asn 
    1130                 1135                 1140             


Gly Lys  Asp Val Tyr Arg Phe  Leu Pro Asn Gly Ile  Met Leu Ser 
    1145                 1150                 1155             


Asn Ala  Phe Tyr Ile Asp Ala  Asn Gly Asn Thr Tyr  Leu Tyr Asn 
    1160                 1165                 1170             


Ser Lys  Gly Gln Met Tyr Lys  Gly Gly Tyr Thr Lys  Phe Asp Val 
    1175                 1180                 1185             


Ser Glu  Thr Asp Lys Asp Gly  Lys Glu Ser Lys Val  Val Lys Phe 
    1190                 1195                 1200             


Arg Tyr  Phe Thr Asn Glu Gly  Val Met Ala Lys Gly  Val Thr Val 
    1205                 1210                 1215             


Ile Asp  Gly Phe Thr Gln Tyr  Phe Gly Glu Asp Gly  Phe Gln Ala 
    1220                 1225                 1230             


Lys Asp  Lys Leu Val Thr Phe  Lys Gly Lys Thr Tyr  Tyr Phe Asp 
    1235                 1240                 1245             


Ala His  Thr Gly Asn Gly Ile  Lys Asp Thr Trp Arg  Asn Ile Asn 
    1250                 1255                 1260             


Gly Lys  Trp Tyr Tyr Phe Asp  Ala Asn Gly Val Ala  Ala Thr Gly 
    1265                 1270                 1275             


Ala Gln  Val Ile Asn Gly Gln  Lys Leu Tyr Phe Asn  Glu Asp Gly 
    1280                 1285                 1290             


Ser Gln  Val Lys Gly Gly Val  Val Lys Asn Ala Asp  Gly Thr Tyr 
    1295                 1300                 1305             


Ser Lys  Tyr Lys Glu Gly Phe  Gly Glu Leu Val Thr  Asn Glu Phe 
    1310                 1315                 1320             


Phe Thr  Thr Asp Gly Asn Val  Trp Tyr Tyr Ala Gly  Ala Asn Gly 
    1325                 1330                 1335             


Lys Thr  Val Thr Gly Ala Gln  Val Ile Asn Gly Gln  His Leu Tyr 
    1340                 1345                 1350             


Phe Asn  Ala Asp Gly Ser Gln  Val Lys Gly Gly Val  Val Lys Asn 
    1355                 1360                 1365             


Ala Asp  Gly Thr Tyr Ser Lys  Tyr Asn Ala Ser Thr  Gly Glu Arg 
    1370                 1375                 1380             


Leu Thr  Asn Glu Phe Phe Thr  Thr Gly Asp Asn Asn  Trp Tyr Tyr 
    1385                 1390                 1395             


Ile Gly  Ala Asn Gly Lys Ser  Val Thr Gly Glu Val  Lys Ile Gly 
    1400                 1405                 1410             


Asp Asp  Thr Tyr Phe Phe Ala  Lys Asp Gly Lys Gln  Val Lys Gly 
    1415                 1420                 1425             


Gln Thr  Val Ser Ala Gly Asn  Gly Arg Ile Ser Tyr  Tyr Tyr Gly 
    1430                 1435                 1440             


Asp Ser  Gly Lys Arg Ala Val  Ser Thr Trp Ile Glu  Ile Gln Pro 
    1445                 1450                 1455             


Gly Val  Tyr Val Tyr Phe Asp  Lys Asn Gly Leu Ala  Tyr Pro Pro 
    1460                 1465                 1470             


Arg Val  Leu Asn 
    1475         


<210>  4
<211>  3147
<212>  DNA
<213>  Aspergillus clavatus

<400>  4
atggccagtc tcgtaggcct tcttgccagt gcttggctcc tcccgtcgac ctacggagcg       60

gcggttcact cgtttgctcc tagtacgacg gcaaccgcag cttactcgca gcatactttg      120

ccttcgtcca ttgacaatgg ggctcagttg attgccaata tcgatgaccc cttggcagtg      180

aatgcgcagt ccgtttgtcc aggctataag gcctcggatg tgcaacagac atcacggggt      240

ttcaccgcca gcctgcagct tgcgggcgag ccgtgcaatg cctatgggat tgacgttgac      300

tcgctgagtc tctcggtgga agttctggcg aaggatcgct tgaatatcca gattgtccct      360

acccatgtgg atagctctaa tgcctcttgg tacattcttc cagaggaccg ggtacccaaa      420

gcgcaagcat ctgccgacgc ctccgtctct caaagtgact tcgagatcga gtggtccaat      480

gacccctcgt tcaatatcaa gatcatccgg aaggcaactg gggatgccct gtttgacaca      540

gccgattcgg tcttggtctt tcagaatcag ttcatcgagt ttgtgtctgc tttgcctgag      600

ggttataatc tttatggatt gggggagcgg atggcccagc tgcggcttct gagaaacgct      660

accctgacca cctacgcggc agatgtcgga gacccgattg atgagtatgt gttagaatct      720

atgaatcctt gatctcgttg gctcacaatg gaccaatagc aacatctatg gacagcatcc      780

tttctacctc gacacgagat actataccaa agatgccaac ggctcatatt ctcttgtgaa      840

caccgatgat gccgatgcgt ctggagatta tgagtccttc tcccacggcg tgttcctgag      900

aaatgcacat ggacaggagg ttattctgca gtctcgcaac attacatggc ggacaatcgg      960

tggaagcatc gatttgacct tctactcagg tcccactcag gcagatgtca ccaagagcta     1020

ccagctcacc acgattggct tgcctgcgat gcaacagtac agcgcccttg gtttccatca     1080

atgccgctgg ggttaccgca gctggtctga actcgaggaa gtcgtaaaca cctttgaaca     1140

gtttgagatt cccctcgaat atatctggtg agctcaattc ttcgtaagaa aatatgggct     1200

cttggtgtct aacgcatttt cccaggaccg acattgacta catgcgtggt taccgcgatt     1260

tcgataatga ccaagtccat ttcccctacg atgaaggcga ggagttcctc gacagacttc     1320

acaaatcagg gcgtcactgg gtccccatcg tcgactccgc catctacatc cctaaccctg     1380

acaatgcgtc tgacgcgtaa gtcattgtgt cttatttggc cagcttttca aacagatgct     1440

tacagacgtg acttcaggta cgacacctat gctagaggag ccaaggatga tgttttcatc     1500

aagaaccctg atggcagcct ttatatcgga gctgtatggc ccggattcac agtcttccct     1560

gattggcaca accccaaagc agcggaatgg tggagcaacg agcttgtcac ttggttcgag     1620

aaagtgcagt atgatggcat ttggattgac atgagcgaag tctcctcttt ctgcgttggt     1680

agctgcggga caggaaatct gcacctgaac cccgcccacc caccatttca acttcctggc     1740

gagccgggta acattgagta tacctatccc gaggccttca atgtgaccaa ctccactgaa     1800

gctgcttctg cctctgctgc ctccgccagc cagtcctctg cagctgctgc gacccaaacc     1860

gacgtcagct cgaccacgac ctcgtacttg cggacgacac ccactcctgg tgtccgtgat     1920

atcaactatc ccccttacgt gatcaaccat gttcaatctg gccatgatct cgctgtccat     1980

gccatctctc ccaacgccac ccacgtggat ggtgttcagg agtacgatgt gcacagtctg     2040

tggggtcatc agatcctcaa cgccacttat cagggattgc tcgaggtctt cactgagaag     2100

cgacctttca tcatcggccg atccaccttt gccggctcag ggaaatgggc cggtcactgg     2160

ggcggtgata acaactctag atggggctct atgttccact ccatttcgca ggctctgtcg     2220

ttctctctct ttggcattcc catgtttggt gttgatactt gtggcttcaa tggcaacacc     2280

gacgaggaac tctgcaaccg atggatgcag ctatcggcct tcttcccatt ctaccgaaac     2340

cacaacactc tcgcggctct ttcgcaggag ccctaccggt gggcctccgt cactgaagca     2400

gccaagactg ccatgagcat tcgatatgcc ctcctgccat acttctacac tctgttccac     2460

caggcgcaca ccaccggttc caccgtcatg cgcgccctcg catgggagtt cccgaacgat     2520

ccctcccttg ccgccgtcga cacccagttc atggtcggac catccattct ggtcacgccc     2580

gtcctcgagc ctcttgccaa aacagtcaag ggcgtcttcc ccggcgtcgg caagggtcag     2640

gtctggtatg actggtacac ccaggccgct gtcgacgcca agcccggcgt caacaccacc     2700

atcccggccc cgctgggcca catccccgtc tatgtccgcg gcggcagcat cctgcccatg     2760

caggagcccg ctcttaccac ccgcgacgcc cgcaagaccc cctggtcgct gcttgccgct     2820

ctggacggta accagaccgc ctccggccag ctgtacctcg acgacgggag cagcgtcaac     2880

ccgtcttcga ccctcaacgt ggagttcgcg gctacccact cgagcatcaa ggtctcggcc     2940

aagggtgatt ggcgcgagaa gaatagtctg gatagcgtga ctgttctcgg tgtcgccaag     3000

gagcctgccc gcgtcacctt caaccgccgc agggtccccc ccgagtcggt ggagtataat     3060

gcgacctccc aggttttgac cgtgagcgga ctgcagaagc tgacgccccg cggggcttgg     3120

gctgaggatt ggattctgaa gtggtaa                                         3147


<210>  5
<211>  990
<212>  PRT
<213>  Aspergillus clavatus

<400>  5

Met Ala Ser Leu Val Gly Leu Leu Ala Ser Ala Trp Leu Leu Pro Ser 
1               5                   10                  15      


Thr Tyr Gly Ala Ala Val His Ser Phe Ala Pro Ser Thr Thr Ala Thr 
            20                  25                  30          


Ala Ala Tyr Ser Gln His Thr Leu Pro Ser Ser Ile Asp Asn Gly Ala 
        35                  40                  45              


Gln Leu Ile Ala Asn Ile Asp Asp Pro Leu Ala Val Asn Ala Gln Ser 
    50                  55                  60                  


Val Cys Pro Gly Tyr Lys Ala Ser Asp Val Gln Gln Thr Ser Arg Gly 
65                  70                  75                  80  


Phe Thr Ala Ser Leu Gln Leu Ala Gly Glu Pro Cys Asn Ala Tyr Gly 
                85                  90                  95      


Ile Asp Val Asp Ser Leu Ser Leu Ser Val Glu Val Leu Ala Lys Asp 
            100                 105                 110         


Arg Leu Asn Ile Gln Ile Val Pro Thr His Val Asp Ser Ser Asn Ala 
        115                 120                 125             


Ser Trp Tyr Ile Leu Pro Glu Asp Arg Val Pro Lys Ala Gln Ala Ser 
    130                 135                 140                 


Ala Asp Ala Ser Val Ser Gln Ser Asp Phe Glu Ile Glu Trp Ser Asn 
145                 150                 155                 160 


Asp Pro Ser Phe Asn Ile Lys Ile Ile Arg Lys Ala Thr Gly Asp Ala 
                165                 170                 175     


Leu Phe Asp Thr Ala Asp Ser Val Leu Val Phe Gln Asn Gln Phe Ile 
            180                 185                 190         


Glu Phe Val Ser Ala Leu Pro Glu Gly Tyr Asn Leu Tyr Gly Leu Gly 
        195                 200                 205             


Glu Arg Met Ala Gln Leu Arg Leu Leu Arg Asn Ala Thr Leu Thr Thr 
    210                 215                 220                 


Tyr Ala Ala Asp Val Gly Asp Pro Ile Asp Asp Asn Ile Tyr Gly Gln 
225                 230                 235                 240 


His Pro Phe Tyr Leu Asp Thr Arg Tyr Tyr Thr Lys Asp Ala Asn Gly 
                245                 250                 255     


Ser Tyr Ser Leu Val Asn Thr Asp Asp Ala Asp Ala Ser Gly Asp Tyr 
            260                 265                 270         


Glu Ser Phe Ser His Gly Val Phe Leu Arg Asn Ala His Gly Gln Glu 
        275                 280                 285             


Val Ile Leu Gln Ser Arg Asn Ile Thr Trp Arg Thr Ile Gly Gly Ser 
    290                 295                 300                 


Ile Asp Leu Thr Phe Tyr Ser Gly Pro Thr Gln Ala Asp Val Thr Lys 
305                 310                 315                 320 


Ser Tyr Gln Leu Thr Thr Ile Gly Leu Pro Ala Met Gln Gln Tyr Ser 
                325                 330                 335     


Ala Leu Gly Phe His Gln Cys Arg Trp Gly Tyr Arg Ser Trp Ser Glu 
            340                 345                 350         


Leu Glu Glu Val Val Asn Thr Phe Glu Gln Phe Glu Ile Pro Leu Glu 
        355                 360                 365             


Tyr Ile Trp Thr Asp Ile Asp Tyr Met Arg Gly Tyr Arg Asp Phe Asp 
    370                 375                 380                 


Asn Asp Gln Val His Phe Pro Tyr Asp Glu Gly Glu Glu Phe Leu Asp 
385                 390                 395                 400 


Arg Leu His Lys Ser Gly Arg His Trp Val Pro Ile Val Asp Ser Ala 
                405                 410                 415     


Ile Tyr Ile Pro Asn Pro Asp Asn Ala Ser Asp Ala Tyr Asp Thr Tyr 
            420                 425                 430         


Ala Arg Gly Ala Lys Asp Asp Val Phe Ile Lys Asn Pro Asp Gly Ser 
        435                 440                 445             


Leu Tyr Ile Gly Ala Val Trp Pro Gly Phe Thr Val Phe Pro Asp Trp 
    450                 455                 460                 


His Asn Pro Lys Ala Ala Glu Trp Trp Ser Asn Glu Leu Val Thr Trp 
465                 470                 475                 480 


Phe Glu Lys Val Gln Tyr Asp Gly Ile Trp Ile Asp Met Ser Glu Val 
                485                 490                 495     


Ser Ser Phe Cys Val Gly Ser Cys Gly Thr Gly Asn Leu His Leu Asn 
            500                 505                 510         


Pro Ala His Pro Pro Phe Gln Leu Pro Gly Glu Pro Gly Asn Ile Glu 
        515                 520                 525             


Tyr Thr Tyr Pro Glu Ala Phe Asn Val Thr Asn Ser Thr Glu Ala Ala 
    530                 535                 540                 


Ser Ala Ser Ala Ala Ser Ala Ser Gln Ser Ser Ala Ala Ala Ala Thr 
545                 550                 555                 560 


Gln Thr Asp Val Ser Ser Thr Thr Thr Ser Tyr Leu Arg Thr Thr Pro 
                565                 570                 575     


Thr Pro Gly Val Arg Asp Ile Asn Tyr Pro Pro Tyr Val Ile Asn His 
            580                 585                 590         


Val Gln Ser Gly His Asp Leu Ala Val His Ala Ile Ser Pro Asn Ala 
        595                 600                 605             


Thr His Val Asp Gly Val Gln Glu Tyr Asp Val His Ser Leu Trp Gly 
    610                 615                 620                 


His Gln Ile Leu Asn Ala Thr Tyr Gln Gly Leu Leu Glu Val Phe Thr 
625                 630                 635                 640 


Glu Lys Arg Pro Phe Ile Ile Gly Arg Ser Thr Phe Ala Gly Ser Gly 
                645                 650                 655     


Lys Trp Ala Gly His Trp Gly Gly Asp Asn Asn Ser Arg Trp Gly Ser 
            660                 665                 670         


Met Phe His Ser Ile Ser Gln Ala Leu Ser Phe Ser Leu Phe Gly Ile 
        675                 680                 685             


Pro Met Phe Gly Val Asp Thr Cys Gly Phe Asn Gly Asn Thr Asp Glu 
    690                 695                 700                 


Glu Leu Cys Asn Arg Trp Met Gln Leu Ser Ala Phe Phe Pro Phe Tyr 
705                 710                 715                 720 


Arg Asn His Asn Thr Leu Ala Ala Leu Ser Gln Glu Pro Tyr Arg Trp 
                725                 730                 735     


Ala Ser Val Thr Glu Ala Ala Lys Thr Ala Met Ser Ile Arg Tyr Ala 
            740                 745                 750         


Leu Leu Pro Tyr Phe Tyr Thr Leu Phe His Gln Ala His Thr Thr Gly 
        755                 760                 765             


Ser Thr Val Met Arg Ala Leu Ala Trp Glu Phe Pro Asn Asp Pro Ser 
    770                 775                 780                 


Leu Ala Ala Val Asp Thr Gln Phe Met Val Gly Pro Ser Ile Leu Val 
785                 790                 795                 800 


Thr Pro Val Leu Glu Pro Leu Ala Lys Thr Val Lys Gly Val Phe Pro 
                805                 810                 815     


Gly Val Gly Lys Gly Gln Val Trp Tyr Asp Trp Tyr Thr Gln Ala Ala 
            820                 825                 830         


Val Asp Ala Lys Pro Gly Val Asn Thr Thr Ile Pro Ala Pro Leu Gly 
        835                 840                 845             


His Ile Pro Val Tyr Val Arg Gly Gly Ser Ile Leu Pro Met Gln Glu 
    850                 855                 860                 


Pro Ala Leu Thr Thr Arg Asp Ala Arg Lys Thr Pro Trp Ser Leu Leu 
865                 870                 875                 880 


Ala Ala Leu Asp Gly Asn Gln Thr Ala Ser Gly Gln Leu Tyr Leu Asp 
                885                 890                 895     


Asp Gly Ser Ser Val Asn Pro Ser Ser Thr Leu Asn Val Glu Phe Ala 
            900                 905                 910         


Ala Thr His Ser Ser Ile Lys Val Ser Ala Lys Gly Asp Trp Arg Glu 
        915                 920                 925             


Lys Asn Ser Leu Asp Ser Val Thr Val Leu Gly Val Ala Lys Glu Pro 
    930                 935                 940                 


Ala Arg Val Thr Phe Asn Arg Arg Arg Val Pro Pro Glu Ser Val Glu 
945                 950                 955                 960 


Tyr Asn Ala Thr Ser Gln Val Leu Thr Val Ser Gly Leu Gln Lys Leu 
                965                 970                 975     


Thr Pro Arg Gly Ala Trp Ala Glu Asp Trp Ile Leu Lys Trp 
            980                 985                 990 


<210>  6
<211>  971
<212>  PRT
<213>  Aspergillus clavatus

<400>  6

Ala Ala Val His Ser Phe Ala Pro Ser Thr Thr Ala Thr Ala Ala Tyr 
1               5                   10                  15      


Ser Gln His Thr Leu Pro Ser Ser Ile Asp Asn Gly Ala Gln Leu Ile 
            20                  25                  30          


Ala Asn Ile Asp Asp Pro Leu Ala Val Asn Ala Gln Ser Val Cys Pro 
        35                  40                  45              


Gly Tyr Lys Ala Ser Asp Val Gln Gln Thr Ser Arg Gly Phe Thr Ala 
    50                  55                  60                  


Ser Leu Gln Leu Ala Gly Glu Pro Cys Asn Ala Tyr Gly Ile Asp Val 
65                  70                  75                  80  


Asp Ser Leu Ser Leu Ser Val Glu Val Leu Ala Lys Asp Arg Leu Asn 
                85                  90                  95      


Ile Gln Ile Val Pro Thr His Val Asp Ser Ser Asn Ala Ser Trp Tyr 
            100                 105                 110         


Ile Leu Pro Glu Asp Arg Val Pro Lys Ala Gln Ala Ser Ala Asp Ala 
        115                 120                 125             


Ser Val Ser Gln Ser Asp Phe Glu Ile Glu Trp Ser Asn Asp Pro Ser 
    130                 135                 140                 


Phe Asn Ile Lys Ile Ile Arg Lys Ala Thr Gly Asp Ala Leu Phe Asp 
145                 150                 155                 160 


Thr Ala Asp Ser Val Leu Val Phe Gln Asn Gln Phe Ile Glu Phe Val 
                165                 170                 175     


Ser Ala Leu Pro Glu Gly Tyr Asn Leu Tyr Gly Leu Gly Glu Arg Met 
            180                 185                 190         


Ala Gln Leu Arg Leu Leu Arg Asn Ala Thr Leu Thr Thr Tyr Ala Ala 
        195                 200                 205             


Asp Val Gly Asp Pro Ile Asp Asp Asn Ile Tyr Gly Gln His Pro Phe 
    210                 215                 220                 


Tyr Leu Asp Thr Arg Tyr Tyr Thr Lys Asp Ala Asn Gly Ser Tyr Ser 
225                 230                 235                 240 


Leu Val Asn Thr Asp Asp Ala Asp Ala Ser Gly Asp Tyr Glu Ser Phe 
                245                 250                 255     


Ser His Gly Val Phe Leu Arg Asn Ala His Gly Gln Glu Val Ile Leu 
            260                 265                 270         


Gln Ser Arg Asn Ile Thr Trp Arg Thr Ile Gly Gly Ser Ile Asp Leu 
        275                 280                 285             


Thr Phe Tyr Ser Gly Pro Thr Gln Ala Asp Val Thr Lys Ser Tyr Gln 
    290                 295                 300                 


Leu Thr Thr Ile Gly Leu Pro Ala Met Gln Gln Tyr Ser Ala Leu Gly 
305                 310                 315                 320 


Phe His Gln Cys Arg Trp Gly Tyr Arg Ser Trp Ser Glu Leu Glu Glu 
                325                 330                 335     


Val Val Asn Thr Phe Glu Gln Phe Glu Ile Pro Leu Glu Tyr Ile Trp 
            340                 345                 350         


Thr Asp Ile Asp Tyr Met Arg Gly Tyr Arg Asp Phe Asp Asn Asp Gln 
        355                 360                 365             


Val His Phe Pro Tyr Asp Glu Gly Glu Glu Phe Leu Asp Arg Leu His 
    370                 375                 380                 


Lys Ser Gly Arg His Trp Val Pro Ile Val Asp Ser Ala Ile Tyr Ile 
385                 390                 395                 400 


Pro Asn Pro Asp Asn Ala Ser Asp Ala Tyr Asp Thr Tyr Ala Arg Gly 
                405                 410                 415     


Ala Lys Asp Asp Val Phe Ile Lys Asn Pro Asp Gly Ser Leu Tyr Ile 
            420                 425                 430         


Gly Ala Val Trp Pro Gly Phe Thr Val Phe Pro Asp Trp His Asn Pro 
        435                 440                 445             


Lys Ala Ala Glu Trp Trp Ser Asn Glu Leu Val Thr Trp Phe Glu Lys 
    450                 455                 460                 


Val Gln Tyr Asp Gly Ile Trp Ile Asp Met Ser Glu Val Ser Ser Phe 
465                 470                 475                 480 


Cys Val Gly Ser Cys Gly Thr Gly Asn Leu His Leu Asn Pro Ala His 
                485                 490                 495     


Pro Pro Phe Gln Leu Pro Gly Glu Pro Gly Asn Ile Glu Tyr Thr Tyr 
            500                 505                 510         


Pro Glu Ala Phe Asn Val Thr Asn Ser Thr Glu Ala Ala Ser Ala Ser 
        515                 520                 525             


Ala Ala Ser Ala Ser Gln Ser Ser Ala Ala Ala Ala Thr Gln Thr Asp 
    530                 535                 540                 


Val Ser Ser Thr Thr Thr Ser Tyr Leu Arg Thr Thr Pro Thr Pro Gly 
545                 550                 555                 560 


Val Arg Asp Ile Asn Tyr Pro Pro Tyr Val Ile Asn His Val Gln Ser 
                565                 570                 575     


Gly His Asp Leu Ala Val His Ala Ile Ser Pro Asn Ala Thr His Val 
            580                 585                 590         


Asp Gly Val Gln Glu Tyr Asp Val His Ser Leu Trp Gly His Gln Ile 
        595                 600                 605             


Leu Asn Ala Thr Tyr Gln Gly Leu Leu Glu Val Phe Thr Glu Lys Arg 
    610                 615                 620                 


Pro Phe Ile Ile Gly Arg Ser Thr Phe Ala Gly Ser Gly Lys Trp Ala 
625                 630                 635                 640 


Gly His Trp Gly Gly Asp Asn Asn Ser Arg Trp Gly Ser Met Phe His 
                645                 650                 655     


Ser Ile Ser Gln Ala Leu Ser Phe Ser Leu Phe Gly Ile Pro Met Phe 
            660                 665                 670         


Gly Val Asp Thr Cys Gly Phe Asn Gly Asn Thr Asp Glu Glu Leu Cys 
        675                 680                 685             


Asn Arg Trp Met Gln Leu Ser Ala Phe Phe Pro Phe Tyr Arg Asn His 
    690                 695                 700                 


Asn Thr Leu Ala Ala Leu Ser Gln Glu Pro Tyr Arg Trp Ala Ser Val 
705                 710                 715                 720 


Thr Glu Ala Ala Lys Thr Ala Met Ser Ile Arg Tyr Ala Leu Leu Pro 
                725                 730                 735     


Tyr Phe Tyr Thr Leu Phe His Gln Ala His Thr Thr Gly Ser Thr Val 
            740                 745                 750         


Met Arg Ala Leu Ala Trp Glu Phe Pro Asn Asp Pro Ser Leu Ala Ala 
        755                 760                 765             


Val Asp Thr Gln Phe Met Val Gly Pro Ser Ile Leu Val Thr Pro Val 
    770                 775                 780                 


Leu Glu Pro Leu Ala Lys Thr Val Lys Gly Val Phe Pro Gly Val Gly 
785                 790                 795                 800 


Lys Gly Gln Val Trp Tyr Asp Trp Tyr Thr Gln Ala Ala Val Asp Ala 
                805                 810                 815     


Lys Pro Gly Val Asn Thr Thr Ile Pro Ala Pro Leu Gly His Ile Pro 
            820                 825                 830         


Val Tyr Val Arg Gly Gly Ser Ile Leu Pro Met Gln Glu Pro Ala Leu 
        835                 840                 845             


Thr Thr Arg Asp Ala Arg Lys Thr Pro Trp Ser Leu Leu Ala Ala Leu 
    850                 855                 860                 


Asp Gly Asn Gln Thr Ala Ser Gly Gln Leu Tyr Leu Asp Asp Gly Ser 
865                 870                 875                 880 


Ser Val Asn Pro Ser Ser Thr Leu Asn Val Glu Phe Ala Ala Thr His 
                885                 890                 895     


Ser Ser Ile Lys Val Ser Ala Lys Gly Asp Trp Arg Glu Lys Asn Ser 
            900                 905                 910         


Leu Asp Ser Val Thr Val Leu Gly Val Ala Lys Glu Pro Ala Arg Val 
        915                 920                 925             


Thr Phe Asn Arg Arg Arg Val Pro Pro Glu Ser Val Glu Tyr Asn Ala 
    930                 935                 940                 


Thr Ser Gln Val Leu Thr Val Ser Gly Leu Gln Lys Leu Thr Pro Arg 
945                 950                 955                 960 


Gly Ala Trp Ala Glu Asp Trp Ile Leu Lys Trp 
                965                 970     


<210>  7
<211>  3158
<212>  DNA
<213>  Neosartorya fischeri

<400>  7
atggccagcc tcctgggcct cgtcgccagt gcttggctcc tccccacggc ctatggtgca       60

agccattcgc ttgcgcctag cacgtccgca acctcagcac acgcgcaata cactttacca      120

tcttctattg acgttggtgc tcaattggtc gccaacatcg acgatcccct tgccgtcgac      180

gcacagtctg tgtgtccggg ctacaaagcc tcaaatgtgc accagacatc ccaaggtttc      240

accgccagcc tacagctcgc gggcgaccca tgcaacgtgt acgggacaga cgttgattcg      300

ctgtctctga cagtggatta tctggccaag gaccgcctga acatccaaat tgttcctacc      360

tacgtggatg cctccaacgc ttcttggtac ctcctctcgg aagacttggt gccccgggct      420

caaggctctg gcgtgtccgc ctctcaaagc gactttgatg tgaagtggtc caatgagcct      480

tctttcaacc tcaaggtcat tcgcaaggct actggagacg tcctcttcga taccgagggc      540

tccgtcctgg tctttgagaa ccagtttatc gagtttgtct cttcgttgcc cgagggttac      600

aacctgtacg gtttgggaga gcgcatggcc cagctgcggc tcttgagaaa cgcgaccctg      660

accacctatg cagcggatgt gggagacccg attgataggt atgttgctga ccatggttga      720

aacctaatgt acgaagtcga caagcttaca atcggctctc cagcaacatc tatggacagc      780

atccgttcta tctcgacact agatactata ctaaaggcac gaatgggtct tactcgcttg      840

tcaacacgga cgaggcggac ttgtcggagg attatgaatc attctcccac ggtgtctttc      900

tgagaaactc tcatggtcag gaggttcttc tgcaaccccg caacatcacc tggcgcacaa      960

ttggtggtag catcgatttg actttctact ccggtcccac gcaagcggac gtcacaaaga     1020

gctaccagct ctccaccatt ggacttcctg caatgcagca gtacagcacc cttggattcc     1080

accaatgccg ctggggctac cagaattggt ctcagctcga ggaagtggtc aacaactttg     1140

agcgatttga gattcccctg gaatacatct ggtcagtctg atttctgagt ttatacatat     1200

ttcccagttc cttttattta cattccttcc aggagcgaca tcgattacat gcttggctac     1260

cgtgactttg agaatgatcc cgaacggttc tcctacgatg aaggcgagga atttctgaac     1320

aaacttcaca agtcgggacg acactacgtt cctatcgttg actcggcaat ctatattccc     1380

aaccccgaca atgcatcgga tgcgtaagtc cttgttatct tatcctcctt gttagatggt     1440

caagttctca cgaacgtttg aattccaggt acgagcctta tgctcgcggg gcaaaggatg     1500

acgttttcat caagaaccct gatggcaccc tctacatcgg tgcagtgtgg ccgggcttta     1560

ctgtcttccc agattggctc aaccccaagg catttgacta ctgggccaac gaactcgtca     1620

tctggtcaaa gaaggttgcg ttcgatggca tctggattga tatgagcgaa gtatcctctt     1680

tctgcgttgg cagctgtgga acaggaaagc tacatctgaa cccggttcac ccaccattcc     1740

agcttcccgg tgaacctgga aatatcggct acgactaccc cgaggccttc aacgtgacga     1800

actctaccga agcggcctct gcctccgccg cctctgccag tcaggcttcg gctgctgctg     1860

ctacccaaac cgccactacg tcaacatcta catcgtatct gcggacgacg cccacgccgg     1920

gcgtccgtga cgtcaactac cctccatatg tgattaatca tgttcaggag ggtcatgacc     1980

ttgccgttca cgccatttct cccaactcta ctcatgcgga cggcgtccag gaatacgatg     2040

ttcacagtct gtggggccac cagatcctca atgccaccta ctacggactg cgccaggtct     2100

tcactgagaa gcgacccttc atcattggtc ggtctacctt tgctggctcg ggcaagtggg     2160

ccggtcactg gggcggtgat aacaactcca aatgggggtc catgttcctg tccatctcgc     2220

agggtctgtc gttctcgctg ttcggtattc ccatgttcgg cgtggatacc tgcggtttca     2280

acggtaacac cgacgaggag ctctgcagcc ggtggatgca gctgtcggcc ttcttcccct     2340

tctaccgcaa ccacaatgtc cttggggcta tcccccagga gccctaccgt tgggcctctg     2400

tcacccaagc ctccaaggct gccatgaaga tccgctattc catcctacct tacttctaca     2460

ctcttttcca ccaggcccac accactggct ctaccgtcat gcgcgctctc gcctgggagt     2520

tccccacgga cccgtccctc gccgccgtcg acacccagtt catggtcggt ccttccatca     2580

tggtcgtccc cgtgctcgag cccctcgccg ataccgtcaa gggcgcgttc ccaggcgtcg     2640

gcaaaggcga agtctggtac gactggtaca cccagaccgc cgtagacgcc aaacccggcg     2700

tcaacaccac cattcccgct ccgctgggcc acattcccgt ctatgtccgt ggaggcagca     2760

tcctgcccat gcaggaaccc gccctcacga ccagagacgc ccgtaacact ccctggtcgc     2820

tactcgtcgc tctgagcggc aaccagactg cctcgggctc gctgtatctc gacgacggaa     2880

ccagcctcaa cccgtcccgc actctcgatg tcgacttcca ggctaccgcc tggagcatca     2940

aggtctcggt caagggtacc tgggaggaga agaaccgcct ggataaggtg actgtcctcg     3000

gcgtgggtga gaagccttcc gctgtgacgt tcaacggccg caacgtccac cctggctcgg     3060

tgcactacaa tgctacctcc aaggtgctgt ctgtgcaggg attgcacagc atgacgcccc     3120

atggcgcctg ggctggaaac tgggttctga aatggtag                             3158


<210>  8
<211>  988
<212>  PRT
<213>  Neosartorya fischeri

<400>  8

Met Ala Ser Leu Leu Gly Leu Val Ala Ser Ala Trp Leu Leu Pro Thr 
1               5                   10                  15      


Ala Tyr Gly Ala Ser His Ser Leu Ala Pro Ser Thr Ser Ala Thr Ser 
            20                  25                  30          


Ala His Ala Gln Tyr Thr Leu Pro Ser Ser Ile Asp Val Gly Ala Gln 
        35                  40                  45              


Leu Val Ala Asn Ile Asp Asp Pro Leu Ala Val Asp Ala Gln Ser Val 
    50                  55                  60                  


Cys Pro Gly Tyr Lys Ala Ser Asn Val His Gln Thr Ser Gln Gly Phe 
65                  70                  75                  80  


Thr Ala Ser Leu Gln Leu Ala Gly Asp Pro Cys Asn Val Tyr Gly Thr 
                85                  90                  95      


Asp Val Asp Ser Leu Ser Leu Thr Val Asp Tyr Leu Ala Lys Asp Arg 
            100                 105                 110         


Leu Asn Ile Gln Ile Val Pro Thr Tyr Val Asp Ala Ser Asn Ala Ser 
        115                 120                 125             


Trp Tyr Leu Leu Ser Glu Asp Leu Val Pro Arg Ala Gln Gly Ser Gly 
    130                 135                 140                 


Val Ser Ala Ser Gln Ser Asp Phe Asp Val Lys Trp Ser Asn Glu Pro 
145                 150                 155                 160 


Ser Phe Asn Leu Lys Val Ile Arg Lys Ala Thr Gly Asp Val Leu Phe 
                165                 170                 175     


Asp Thr Glu Gly Ser Val Leu Val Phe Glu Asn Gln Phe Ile Glu Phe 
            180                 185                 190         


Val Ser Ser Leu Pro Glu Gly Tyr Asn Leu Tyr Gly Leu Gly Glu Arg 
        195                 200                 205             


Met Ala Gln Leu Arg Leu Leu Arg Asn Ala Thr Leu Thr Thr Tyr Ala 
    210                 215                 220                 


Ala Asp Val Gly Asp Pro Ile Asp Ser Asn Ile Tyr Gly Gln His Pro 
225                 230                 235                 240 


Phe Tyr Leu Asp Thr Arg Tyr Tyr Thr Lys Gly Thr Asn Gly Ser Tyr 
                245                 250                 255     


Ser Leu Val Asn Thr Asp Glu Ala Asp Leu Ser Glu Asp Tyr Glu Ser 
            260                 265                 270         


Phe Ser His Gly Val Phe Leu Arg Asn Ser His Gly Gln Glu Val Leu 
        275                 280                 285             


Leu Gln Pro Arg Asn Ile Thr Trp Arg Thr Ile Gly Gly Ser Ile Asp 
    290                 295                 300                 


Leu Thr Phe Tyr Ser Gly Pro Thr Gln Ala Asp Val Thr Lys Ser Tyr 
305                 310                 315                 320 


Gln Leu Ser Thr Ile Gly Leu Pro Ala Met Gln Gln Tyr Ser Thr Leu 
                325                 330                 335     


Gly Phe His Gln Cys Arg Trp Gly Tyr Gln Asn Trp Ser Gln Leu Glu 
            340                 345                 350         


Glu Val Val Asn Asn Phe Glu Arg Phe Glu Ile Pro Leu Glu Tyr Ile 
        355                 360                 365             


Trp Ser Asp Ile Asp Tyr Met Leu Gly Tyr Arg Asp Phe Glu Asn Asp 
    370                 375                 380                 


Pro Glu Arg Phe Ser Tyr Asp Glu Gly Glu Glu Phe Leu Asn Lys Leu 
385                 390                 395                 400 


His Lys Ser Gly Arg His Tyr Val Pro Ile Val Asp Ser Ala Ile Tyr 
                405                 410                 415     


Ile Pro Asn Pro Asp Asn Ala Ser Asp Ala Tyr Glu Pro Tyr Ala Arg 
            420                 425                 430         


Gly Ala Lys Asp Asp Val Phe Ile Lys Asn Pro Asp Gly Thr Leu Tyr 
        435                 440                 445             


Ile Gly Ala Val Trp Pro Gly Phe Thr Val Phe Pro Asp Trp Leu Asn 
    450                 455                 460                 


Pro Lys Ala Phe Asp Tyr Trp Ala Asn Glu Leu Val Ile Trp Ser Lys 
465                 470                 475                 480 


Lys Val Ala Phe Asp Gly Ile Trp Ile Asp Met Ser Glu Val Ser Ser 
                485                 490                 495     


Phe Cys Val Gly Ser Cys Gly Thr Gly Lys Leu His Leu Asn Pro Val 
            500                 505                 510         


His Pro Pro Phe Gln Leu Pro Gly Glu Pro Gly Asn Ile Gly Tyr Asp 
        515                 520                 525             


Tyr Pro Glu Ala Phe Asn Val Thr Asn Ser Thr Glu Ala Ala Ser Ala 
    530                 535                 540                 


Ser Ala Ala Ser Ala Ser Gln Ala Ser Ala Ala Ala Ala Thr Gln Thr 
545                 550                 555                 560 


Ala Thr Thr Ser Thr Ser Thr Ser Tyr Leu Arg Thr Thr Pro Thr Pro 
                565                 570                 575     


Gly Val Arg Asp Val Asn Tyr Pro Pro Tyr Val Ile Asn His Val Gln 
            580                 585                 590         


Glu Gly His Asp Leu Ala Val His Ala Ile Ser Pro Asn Ser Thr His 
        595                 600                 605             


Ala Asp Gly Val Gln Glu Tyr Asp Val His Ser Leu Trp Gly His Gln 
    610                 615                 620                 


Ile Leu Asn Ala Thr Tyr Tyr Gly Leu Arg Gln Val Phe Thr Glu Lys 
625                 630                 635                 640 


Arg Pro Phe Ile Ile Gly Arg Ser Thr Phe Ala Gly Ser Gly Lys Trp 
                645                 650                 655     


Ala Gly His Trp Gly Gly Asp Asn Asn Ser Lys Trp Gly Ser Met Phe 
            660                 665                 670         


Leu Ser Ile Ser Gln Gly Leu Ser Phe Ser Leu Phe Gly Ile Pro Met 
        675                 680                 685             


Phe Gly Val Asp Thr Cys Gly Phe Asn Gly Asn Thr Asp Glu Glu Leu 
    690                 695                 700                 


Cys Ser Arg Trp Met Gln Leu Ser Ala Phe Phe Pro Phe Tyr Arg Asn 
705                 710                 715                 720 


His Asn Val Leu Gly Ala Ile Pro Gln Glu Pro Tyr Arg Trp Ala Ser 
                725                 730                 735     


Val Thr Gln Ala Ser Lys Ala Ala Met Lys Ile Arg Tyr Ser Ile Leu 
            740                 745                 750         


Pro Tyr Phe Tyr Thr Leu Phe His Gln Ala His Thr Thr Gly Ser Thr 
        755                 760                 765             


Val Met Arg Ala Leu Ala Trp Glu Phe Pro Thr Asp Pro Ser Leu Ala 
    770                 775                 780                 


Ala Val Asp Thr Gln Phe Met Val Gly Pro Ser Ile Met Val Val Pro 
785                 790                 795                 800 


Val Leu Glu Pro Leu Ala Asp Thr Val Lys Gly Ala Phe Pro Gly Val 
                805                 810                 815     


Gly Lys Gly Glu Val Trp Tyr Asp Trp Tyr Thr Gln Thr Ala Val Asp 
            820                 825                 830         


Ala Lys Pro Gly Val Asn Thr Thr Ile Pro Ala Pro Leu Gly His Ile 
        835                 840                 845             


Pro Val Tyr Val Arg Gly Gly Ser Ile Leu Pro Met Gln Glu Pro Ala 
    850                 855                 860                 


Leu Thr Thr Arg Asp Ala Arg Asn Thr Pro Trp Ser Leu Leu Val Ala 
865                 870                 875                 880 


Leu Ser Gly Asn Gln Thr Ala Ser Gly Ser Leu Tyr Leu Asp Asp Gly 
                885                 890                 895     


Thr Ser Leu Asn Pro Ser Arg Thr Leu Asp Val Asp Phe Gln Ala Thr 
            900                 905                 910         


Ala Trp Ser Ile Lys Val Ser Val Lys Gly Thr Trp Glu Glu Lys Asn 
        915                 920                 925             


Arg Leu Asp Lys Val Thr Val Leu Gly Val Gly Glu Lys Pro Ser Ala 
    930                 935                 940                 


Val Thr Phe Asn Gly Arg Asn Val His Pro Gly Ser Val His Tyr Asn 
945                 950                 955                 960 


Ala Thr Ser Lys Val Leu Ser Val Gln Gly Leu His Ser Met Thr Pro 
                965                 970                 975     


His Gly Ala Trp Ala Gly Asn Trp Val Leu Lys Trp 
            980                 985             


<210>  9
<211>  969
<212>  PRT
<213>  Neosartorya fischeri

<400>  9

Ala Ser His Ser Leu Ala Pro Ser Thr Ser Ala Thr Ser Ala His Ala 
1               5                   10                  15      


Gln Tyr Thr Leu Pro Ser Ser Ile Asp Val Gly Ala Gln Leu Val Ala 
            20                  25                  30          


Asn Ile Asp Asp Pro Leu Ala Val Asp Ala Gln Ser Val Cys Pro Gly 
        35                  40                  45              


Tyr Lys Ala Ser Asn Val His Gln Thr Ser Gln Gly Phe Thr Ala Ser 
    50                  55                  60                  


Leu Gln Leu Ala Gly Asp Pro Cys Asn Val Tyr Gly Thr Asp Val Asp 
65                  70                  75                  80  


Ser Leu Ser Leu Thr Val Asp Tyr Leu Ala Lys Asp Arg Leu Asn Ile 
                85                  90                  95      


Gln Ile Val Pro Thr Tyr Val Asp Ala Ser Asn Ala Ser Trp Tyr Leu 
            100                 105                 110         


Leu Ser Glu Asp Leu Val Pro Arg Ala Gln Gly Ser Gly Val Ser Ala 
        115                 120                 125             


Ser Gln Ser Asp Phe Asp Val Lys Trp Ser Asn Glu Pro Ser Phe Asn 
    130                 135                 140                 


Leu Lys Val Ile Arg Lys Ala Thr Gly Asp Val Leu Phe Asp Thr Glu 
145                 150                 155                 160 


Gly Ser Val Leu Val Phe Glu Asn Gln Phe Ile Glu Phe Val Ser Ser 
                165                 170                 175     


Leu Pro Glu Gly Tyr Asn Leu Tyr Gly Leu Gly Glu Arg Met Ala Gln 
            180                 185                 190         


Leu Arg Leu Leu Arg Asn Ala Thr Leu Thr Thr Tyr Ala Ala Asp Val 
        195                 200                 205             


Gly Asp Pro Ile Asp Ser Asn Ile Tyr Gly Gln His Pro Phe Tyr Leu 
    210                 215                 220                 


Asp Thr Arg Tyr Tyr Thr Lys Gly Thr Asn Gly Ser Tyr Ser Leu Val 
225                 230                 235                 240 


Asn Thr Asp Glu Ala Asp Leu Ser Glu Asp Tyr Glu Ser Phe Ser His 
                245                 250                 255     


Gly Val Phe Leu Arg Asn Ser His Gly Gln Glu Val Leu Leu Gln Pro 
            260                 265                 270         


Arg Asn Ile Thr Trp Arg Thr Ile Gly Gly Ser Ile Asp Leu Thr Phe 
        275                 280                 285             


Tyr Ser Gly Pro Thr Gln Ala Asp Val Thr Lys Ser Tyr Gln Leu Ser 
    290                 295                 300                 


Thr Ile Gly Leu Pro Ala Met Gln Gln Tyr Ser Thr Leu Gly Phe His 
305                 310                 315                 320 


Gln Cys Arg Trp Gly Tyr Gln Asn Trp Ser Gln Leu Glu Glu Val Val 
                325                 330                 335     


Asn Asn Phe Glu Arg Phe Glu Ile Pro Leu Glu Tyr Ile Trp Ser Asp 
            340                 345                 350         


Ile Asp Tyr Met Leu Gly Tyr Arg Asp Phe Glu Asn Asp Pro Glu Arg 
        355                 360                 365             


Phe Ser Tyr Asp Glu Gly Glu Glu Phe Leu Asn Lys Leu His Lys Ser 
    370                 375                 380                 


Gly Arg His Tyr Val Pro Ile Val Asp Ser Ala Ile Tyr Ile Pro Asn 
385                 390                 395                 400 


Pro Asp Asn Ala Ser Asp Ala Tyr Glu Pro Tyr Ala Arg Gly Ala Lys 
                405                 410                 415     


Asp Asp Val Phe Ile Lys Asn Pro Asp Gly Thr Leu Tyr Ile Gly Ala 
            420                 425                 430         


Val Trp Pro Gly Phe Thr Val Phe Pro Asp Trp Leu Asn Pro Lys Ala 
        435                 440                 445             


Phe Asp Tyr Trp Ala Asn Glu Leu Val Ile Trp Ser Lys Lys Val Ala 
    450                 455                 460                 


Phe Asp Gly Ile Trp Ile Asp Met Ser Glu Val Ser Ser Phe Cys Val 
465                 470                 475                 480 


Gly Ser Cys Gly Thr Gly Lys Leu His Leu Asn Pro Val His Pro Pro 
                485                 490                 495     


Phe Gln Leu Pro Gly Glu Pro Gly Asn Ile Gly Tyr Asp Tyr Pro Glu 
            500                 505                 510         


Ala Phe Asn Val Thr Asn Ser Thr Glu Ala Ala Ser Ala Ser Ala Ala 
        515                 520                 525             


Ser Ala Ser Gln Ala Ser Ala Ala Ala Ala Thr Gln Thr Ala Thr Thr 
    530                 535                 540                 


Ser Thr Ser Thr Ser Tyr Leu Arg Thr Thr Pro Thr Pro Gly Val Arg 
545                 550                 555                 560 


Asp Val Asn Tyr Pro Pro Tyr Val Ile Asn His Val Gln Glu Gly His 
                565                 570                 575     


Asp Leu Ala Val His Ala Ile Ser Pro Asn Ser Thr His Ala Asp Gly 
            580                 585                 590         


Val Gln Glu Tyr Asp Val His Ser Leu Trp Gly His Gln Ile Leu Asn 
        595                 600                 605             


Ala Thr Tyr Tyr Gly Leu Arg Gln Val Phe Thr Glu Lys Arg Pro Phe 
    610                 615                 620                 


Ile Ile Gly Arg Ser Thr Phe Ala Gly Ser Gly Lys Trp Ala Gly His 
625                 630                 635                 640 


Trp Gly Gly Asp Asn Asn Ser Lys Trp Gly Ser Met Phe Leu Ser Ile 
                645                 650                 655     


Ser Gln Gly Leu Ser Phe Ser Leu Phe Gly Ile Pro Met Phe Gly Val 
            660                 665                 670         


Asp Thr Cys Gly Phe Asn Gly Asn Thr Asp Glu Glu Leu Cys Ser Arg 
        675                 680                 685             


Trp Met Gln Leu Ser Ala Phe Phe Pro Phe Tyr Arg Asn His Asn Val 
    690                 695                 700                 


Leu Gly Ala Ile Pro Gln Glu Pro Tyr Arg Trp Ala Ser Val Thr Gln 
705                 710                 715                 720 


Ala Ser Lys Ala Ala Met Lys Ile Arg Tyr Ser Ile Leu Pro Tyr Phe 
                725                 730                 735     


Tyr Thr Leu Phe His Gln Ala His Thr Thr Gly Ser Thr Val Met Arg 
            740                 745                 750         


Ala Leu Ala Trp Glu Phe Pro Thr Asp Pro Ser Leu Ala Ala Val Asp 
        755                 760                 765             


Thr Gln Phe Met Val Gly Pro Ser Ile Met Val Val Pro Val Leu Glu 
    770                 775                 780                 


Pro Leu Ala Asp Thr Val Lys Gly Ala Phe Pro Gly Val Gly Lys Gly 
785                 790                 795                 800 


Glu Val Trp Tyr Asp Trp Tyr Thr Gln Thr Ala Val Asp Ala Lys Pro 
                805                 810                 815     


Gly Val Asn Thr Thr Ile Pro Ala Pro Leu Gly His Ile Pro Val Tyr 
            820                 825                 830         


Val Arg Gly Gly Ser Ile Leu Pro Met Gln Glu Pro Ala Leu Thr Thr 
        835                 840                 845             


Arg Asp Ala Arg Asn Thr Pro Trp Ser Leu Leu Val Ala Leu Ser Gly 
    850                 855                 860                 


Asn Gln Thr Ala Ser Gly Ser Leu Tyr Leu Asp Asp Gly Thr Ser Leu 
865                 870                 875                 880 


Asn Pro Ser Arg Thr Leu Asp Val Asp Phe Gln Ala Thr Ala Trp Ser 
                885                 890                 895     


Ile Lys Val Ser Val Lys Gly Thr Trp Glu Glu Lys Asn Arg Leu Asp 
            900                 905                 910         


Lys Val Thr Val Leu Gly Val Gly Glu Lys Pro Ser Ala Val Thr Phe 
        915                 920                 925             


Asn Gly Arg Asn Val His Pro Gly Ser Val His Tyr Asn Ala Thr Ser 
    930                 935                 940                 


Lys Val Leu Ser Val Gln Gly Leu His Ser Met Thr Pro His Gly Ala 
945                 950                 955                 960 


Trp Ala Gly Asn Trp Val Leu Lys Trp 
                965                 


<210>  10
<211>  3385
<212>  DNA
<213>  Neurospora crassa

<400>  10
atggccgtct tcacatcggc ttccttcttt cttcttgcgg ctcttgtccc tcaatggaca       60

tctgctcaac atgtatctgt ggttgcaacg tcatctggac ctggtgtgtt gagcgggacg      120

gtggcagggg attcccctat gttcactttc ccagcttcgg ctgacatcgg accaaatgtc      180

ttaccgaaca ttttcgaccc gcaagcagtt aatgttcaaa gcgtctgtcc aggatataca      240

gctgctaatg cacaaaagac ggagaaggga ctcacggctg acttgaccct tgctggccct      300

ccctgcaatg tctatggcaa cgacatcgag cacctgaagc ttaccattga gtttcaggcg      360

gacaatcgga tcaatgtcca gattcaacct cgctatactg gccccggtaa tgaaacctgg      420

ttcatacttc ctgaggtgct cgtgccacga ccagaggccg agcctgatgc gaatgccgct      480

agaagcaagc tggaaatctc gtggtcgaat gagcccacct tctccttcac agtgaagcgt      540

aaggagactg gagatgtctt gttcacgacc gagggccgtg tccttgttta tgaggatcag      600

ttcatcgagt tcggctcctc tttacccgag aattacaacc tgtatggtct cggcgaagtt      660

atgcatggct ttagactggg gaacaatctg acacgtaagt ctctttactt aacatgaatg      720

tgcatcgtgg attgcatctg actaacacca tctccaggca cgctgttcgc tgcggatgtg      780

ggcgacaacc tcgatgccaa catctacggc aaccacccga tctatctcga caccagatac      840

ttcaccaagg acgagtctgg aaaattaagc tacgtttccg acccagcaga caagaatgcc      900

aaatatgttt cgtatacaaa cggtgtcttc cttcgaaatg ctcatgcaca ggaagtgctc      960

cttcgacccg aaggtatcac ctggaggact ctcggcggaa gcatcgattt gtacttcttt     1020

gagggacctt ttgctcagga tatcatcaag tcttatcagc tcagtaccgt tggtcttcct     1080

gcaatgcagc agtattggac tcttggcttt caccaatgtc gctggggata ctcgaactgg     1140

actgttgtga aggatgtcgt tgacaatttc cgcaagtttg gcatcccgtt ggagacaatc     1200

tggagtgagt gaacccaagt ccttcagcat cagaatcttc cccatccatg cttttactga     1260

cttttttaag ccgacattga ttacatgaag ggctatcgtg actttgaaaa cgaccctgat     1320

cagttcagct acgaggaagg cgccaggttc ctcgaggagc ttcacaagaa tcaccagcac     1380

tacgtgccga ttgtcgactc ggccatctat gttccaaatc ctgacaagcc agaagatgat     1440

tacgaacctt accaccgtgg actcgaagct gatgctttca tcatgaaccc agacggttcg     1500

ctctatatcg gtgcagtgtg gcctggctac accgtgtttc cggactggat tggtgccgcc     1560

ctcaacggta caggtaccgt cggctggtgg acggacgagt ttgttaggta ctataagaag     1620

gtcgcttttg atggcatctg gattgacatg agcgaggttg cttctttctg catcggaagc     1680

tgtggcacgg gcaacctgac gctcaatccg gttcatccac catggggtct tcccggtgag     1740

ccaggcgctc ttgtgctcga ttaccccgaa ggttttgaaa aaaccaacgc gagtgaggca     1800

tcctctgcaa cgtcggttta caaaacgcag aacccagacc ccacgactac agccagcacc     1860

actagcacta cttcttacct caggacgaca ccgactcctg gagtgcgcaa tatcaactat     1920

ccaccatatg tcatcaacaa cttccacggc gacattggta ctcacgccct gagccccaat     1980

ggtacccacc atggcggcac agtcgactat gacttccaca acttgttcgg ccatcagatc     2040

ctccacgcaa cctaccaggc acttctcaaa gtctttgagg gcaagcgtcc ttttatcatc     2100

ggccgcagca cctttgcggg ttctggcaaa tgggccggtc actggggtgg tgataactat     2160

tccctatggg cgtttctgta ctttagcatt ccccaggccc tatccttctc catcttcggt     2220

ttccccatgt tcggcgtaga tacctgcggc ttcaatggca acacggacca cgagctgtgc     2280

tcacgatgga tgcagctcag cgcctttttc ccattctacc gcaaccacaa cgtccgtggc     2340

gccatcagcc aggagcccta cgtgtggagc tctgtgatcg atgcgtccaa gaaggcgatg     2400

aggattcgat acctcctgct cccgtacatg tacacactta tggcccaggc cagcctgtct     2460

ggagatacgg tcatgcgcgc actctcgtgg gagttcccgc aagagccgtg gttggcggat     2520

gcggatcgcc agttcatgtt gggcagcgcg gtgatggtga caccatgtct tgttcaaggg     2580

gccaatacag tggacggcgt gtttcctgga gttggcgatg ggaccatctg gtatgattgg     2640

tatacataca aggccgccag tgagggtgtt cagcctgggg agaatgtaac gatcgatgca     2700

cctctgggac acattccggt ttttctacgg ggtggccatg tcattccagt gcaagagccg     2760

ggcatgacta cgacggagag cagacaaaat gagtggagtg tcatcgttgc tcttgatggt     2820

gcgggtaagg cgaatggtac gttgtatctg gatgatggtg agagtttgga gccgggtgag     2880

aatgtgaagt gggttgatgt gagtcttctt ccgttctttc tatttttctt ctcttttccg     2940

tgagtgttca gtcggtcgat tgccactcgc tcctctcgcg acaaggtcga aagtgctaac     3000

cgggtttggc tgtttctagt tcacggttga gaagaactca tttcgagtga cacctcaggg     3060

caagtacctt gaccgaaact cactggccaa cgtcacgatc ctgggagtgg ccgaggcacc     3120

tctgggagtg gctattaata gtcatctgct cggatcagct tcttggtcct acgactccga     3180

ggggaagttc ctttcggtaa ccgagctgca ggacaacttc aaggaagggg cgtgggcatc     3240

caactggacg ctgtcgtgga actcggcctc aaactcgggc tcgtctcctg ttcagggagg     3300

cggcggcagg ctcgagttca gcacgcccaa tttgctccat gcagctgctt tcggcatcct     3360

ttttggccgc atgtttgtag tttag                                           3385


<210>  11
<211>  1044
<212>  PRT
<213>  Neurospora crassa

<400>  11

Met Ala Val Phe Thr Ser Ala Ser Phe Phe Leu Leu Ala Ala Leu Val 
1               5                   10                  15      


Pro Gln Trp Thr Ser Ala Gln His Val Ser Val Val Ala Thr Ser Ser 
            20                  25                  30          


Gly Pro Gly Val Leu Ser Gly Thr Val Ala Gly Asp Ser Pro Met Phe 
        35                  40                  45              


Thr Phe Pro Ala Ser Ala Asp Ile Gly Pro Asn Val Leu Pro Asn Ile 
    50                  55                  60                  


Phe Asp Pro Gln Ala Val Asn Val Gln Ser Val Cys Pro Gly Tyr Thr 
65                  70                  75                  80  


Ala Ala Asn Ala Gln Lys Thr Glu Lys Gly Leu Thr Ala Asp Leu Thr 
                85                  90                  95      


Leu Ala Gly Pro Pro Cys Asn Val Tyr Gly Asn Asp Ile Glu His Leu 
            100                 105                 110         


Lys Leu Thr Ile Glu Phe Gln Ala Asp Asn Arg Ile Asn Val Gln Ile 
        115                 120                 125             


Gln Pro Arg Tyr Thr Gly Pro Gly Asn Glu Thr Trp Phe Ile Leu Pro 
    130                 135                 140                 


Glu Val Leu Val Pro Arg Pro Glu Ala Glu Pro Asp Ala Asn Ala Ala 
145                 150                 155                 160 


Arg Ser Lys Leu Glu Ile Ser Trp Ser Asn Glu Pro Thr Phe Ser Phe 
                165                 170                 175     


Thr Val Lys Arg Lys Glu Thr Gly Asp Val Leu Phe Thr Thr Glu Gly 
            180                 185                 190         


Arg Val Leu Val Tyr Glu Asp Gln Phe Ile Glu Phe Gly Ser Ser Leu 
        195                 200                 205             


Pro Glu Asn Tyr Asn Leu Tyr Gly Leu Gly Glu Val Met His Gly Phe 
    210                 215                 220                 


Arg Leu Gly Asn Asn Leu Thr Arg Thr Leu Phe Ala Ala Asp Val Gly 
225                 230                 235                 240 


Asp Asn Leu Asp Ala Asn Ile Tyr Gly Asn His Pro Ile Tyr Leu Asp 
                245                 250                 255     


Thr Arg Tyr Phe Thr Lys Asp Glu Ser Gly Lys Leu Ser Tyr Val Ser 
            260                 265                 270         


Asp Pro Ala Asp Lys Asn Ala Lys Tyr Val Ser Tyr Thr Asn Gly Val 
        275                 280                 285             


Phe Leu Arg Asn Ala His Ala Gln Glu Val Leu Leu Arg Pro Glu Gly 
    290                 295                 300                 


Ile Thr Trp Arg Thr Leu Gly Gly Ser Ile Asp Leu Tyr Phe Phe Glu 
305                 310                 315                 320 


Gly Pro Phe Ala Gln Asp Ile Ile Lys Ser Tyr Gln Leu Ser Thr Val 
                325                 330                 335     


Gly Leu Pro Ala Met Gln Gln Tyr Trp Thr Leu Gly Phe His Gln Cys 
            340                 345                 350         


Arg Trp Gly Tyr Ser Asn Trp Thr Val Val Lys Asp Val Val Asp Asn 
        355                 360                 365             


Phe Arg Lys Phe Gly Ile Pro Leu Glu Thr Ile Trp Thr Asp Ile Asp 
    370                 375                 380                 


Tyr Met Lys Gly Tyr Arg Asp Phe Glu Asn Asp Pro Asp Gln Phe Ser 
385                 390                 395                 400 


Tyr Glu Glu Gly Ala Arg Phe Leu Glu Glu Leu His Lys Asn His Gln 
                405                 410                 415     


His Tyr Val Pro Ile Val Asp Ser Ala Ile Tyr Val Pro Asn Pro Asp 
            420                 425                 430         


Lys Pro Glu Asp Asp Tyr Glu Pro Tyr His Arg Gly Leu Glu Ala Asp 
        435                 440                 445             


Ala Phe Ile Met Asn Pro Asp Gly Ser Leu Tyr Ile Gly Ala Val Trp 
    450                 455                 460                 


Pro Gly Tyr Thr Val Phe Pro Asp Trp Ile Gly Ala Ala Leu Asn Gly 
465                 470                 475                 480 


Thr Gly Thr Val Gly Trp Trp Thr Asp Glu Phe Val Arg Tyr Tyr Lys 
                485                 490                 495     


Lys Val Ala Phe Asp Gly Ile Trp Ile Asp Met Ser Glu Val Ala Ser 
            500                 505                 510         


Phe Cys Ile Gly Ser Cys Gly Thr Gly Asn Leu Thr Leu Asn Pro Val 
        515                 520                 525             


His Pro Pro Trp Gly Leu Pro Gly Glu Pro Gly Ala Leu Val Leu Asp 
    530                 535                 540                 


Tyr Pro Glu Gly Phe Glu Lys Thr Asn Ala Ser Glu Ala Ser Ser Ala 
545                 550                 555                 560 


Thr Ser Val Tyr Lys Thr Gln Asn Pro Asp Pro Thr Thr Thr Ala Ser 
                565                 570                 575     


Thr Thr Ser Thr Thr Ser Tyr Leu Arg Thr Thr Pro Thr Pro Gly Val 
            580                 585                 590         


Arg Asn Ile Asn Tyr Pro Pro Tyr Val Ile Asn Asn Phe His Gly Asp 
        595                 600                 605             


Ile Gly Thr His Ala Leu Ser Pro Asn Gly Thr His His Gly Gly Thr 
    610                 615                 620                 


Val Asp Tyr Asp Phe His Asn Leu Phe Gly His Gln Ile Leu His Ala 
625                 630                 635                 640 


Thr Tyr Gln Ala Leu Leu Lys Val Phe Glu Gly Lys Arg Pro Phe Ile 
                645                 650                 655     


Ile Gly Arg Ser Thr Phe Ala Gly Ser Gly Lys Trp Ala Gly His Trp 
            660                 665                 670         


Gly Gly Asp Asn Tyr Ser Leu Trp Ala Phe Leu Tyr Phe Ser Ile Pro 
        675                 680                 685             


Gln Ala Leu Ser Phe Ser Ile Phe Gly Phe Pro Met Phe Gly Val Asp 
    690                 695                 700                 


Thr Cys Gly Phe Asn Gly Asn Thr Asp His Glu Leu Cys Ser Arg Trp 
705                 710                 715                 720 


Met Gln Leu Ser Ala Phe Phe Pro Phe Tyr Arg Asn His Asn Val Arg 
                725                 730                 735     


Gly Ala Ile Ser Gln Glu Pro Tyr Val Trp Ser Ser Val Ile Asp Ala 
            740                 745                 750         


Ser Lys Lys Ala Met Arg Ile Arg Tyr Leu Leu Leu Pro Tyr Met Tyr 
        755                 760                 765             


Thr Leu Met Ala Gln Ala Ser Leu Ser Gly Asp Thr Val Met Arg Ala 
    770                 775                 780                 


Leu Ser Trp Glu Phe Pro Gln Glu Pro Trp Leu Ala Asp Ala Asp Arg 
785                 790                 795                 800 


Gln Phe Met Leu Gly Ser Ala Val Met Val Thr Pro Cys Leu Val Gln 
                805                 810                 815     


Gly Ala Asn Thr Val Asp Gly Val Phe Pro Gly Val Gly Asp Gly Thr 
            820                 825                 830         


Ile Trp Tyr Asp Trp Tyr Thr Tyr Lys Ala Ala Ser Glu Gly Val Gln 
        835                 840                 845             


Pro Gly Glu Asn Val Thr Ile Asp Ala Pro Leu Gly His Ile Pro Val 
    850                 855                 860                 


Phe Leu Arg Gly Gly His Val Ile Pro Val Gln Glu Pro Gly Met Thr 
865                 870                 875                 880 


Thr Thr Glu Ser Arg Gln Asn Glu Trp Ser Val Ile Val Ala Leu Asp 
                885                 890                 895     


Gly Ala Gly Lys Ala Asn Gly Thr Leu Tyr Leu Asp Asp Gly Glu Ser 
            900                 905                 910         


Leu Glu Pro Gly Glu Asn Val Lys Trp Val Asp Phe Thr Val Glu Lys 
        915                 920                 925             


Asn Ser Phe Arg Val Thr Pro Gln Gly Lys Tyr Leu Asp Arg Asn Ser 
    930                 935                 940                 


Leu Ala Asn Val Thr Ile Leu Gly Val Ala Glu Ala Pro Leu Gly Val 
945                 950                 955                 960 


Ala Ile Asn Ser His Leu Leu Gly Ser Ala Ser Trp Ser Tyr Asp Ser 
                965                 970                 975     


Glu Gly Lys Phe Leu Ser Val Thr Glu Leu Gln Asp Asn Phe Lys Glu 
            980                 985                 990         


Gly Ala Trp Ala Ser Asn Trp Thr  Leu Ser Trp Asn Ser  Ala Ser Asn 
        995                 1000                 1005             


Ser Gly  Ser Ser Pro Val Gln  Gly Gly Gly Gly Arg  Leu Glu Phe 
    1010                 1015                 1020             


Ser Thr  Pro Asn Leu Leu His  Ala Ala Ala Phe Gly  Ile Leu Phe 
    1025                 1030                 1035             


Gly Arg  Met Phe Val Val 
    1040                 


<210>  12
<211>  1022
<212>  PRT
<213>  Neurospora crassa

<400>  12

Gln His Val Ser Val Val Ala Thr Ser Ser Gly Pro Gly Val Leu Ser 
1               5                   10                  15      


Gly Thr Val Ala Gly Asp Ser Pro Met Phe Thr Phe Pro Ala Ser Ala 
            20                  25                  30          


Asp Ile Gly Pro Asn Val Leu Pro Asn Ile Phe Asp Pro Gln Ala Val 
        35                  40                  45              


Asn Val Gln Ser Val Cys Pro Gly Tyr Thr Ala Ala Asn Ala Gln Lys 
    50                  55                  60                  


Thr Glu Lys Gly Leu Thr Ala Asp Leu Thr Leu Ala Gly Pro Pro Cys 
65                  70                  75                  80  


Asn Val Tyr Gly Asn Asp Ile Glu His Leu Lys Leu Thr Ile Glu Phe 
                85                  90                  95      


Gln Ala Asp Asn Arg Ile Asn Val Gln Ile Gln Pro Arg Tyr Thr Gly 
            100                 105                 110         


Pro Gly Asn Glu Thr Trp Phe Ile Leu Pro Glu Val Leu Val Pro Arg 
        115                 120                 125             


Pro Glu Ala Glu Pro Asp Ala Asn Ala Ala Arg Ser Lys Leu Glu Ile 
    130                 135                 140                 


Ser Trp Ser Asn Glu Pro Thr Phe Ser Phe Thr Val Lys Arg Lys Glu 
145                 150                 155                 160 


Thr Gly Asp Val Leu Phe Thr Thr Glu Gly Arg Val Leu Val Tyr Glu 
                165                 170                 175     


Asp Gln Phe Ile Glu Phe Gly Ser Ser Leu Pro Glu Asn Tyr Asn Leu 
            180                 185                 190         


Tyr Gly Leu Gly Glu Val Met His Gly Phe Arg Leu Gly Asn Asn Leu 
        195                 200                 205             


Thr Arg Thr Leu Phe Ala Ala Asp Val Gly Asp Asn Leu Asp Ala Asn 
    210                 215                 220                 


Ile Tyr Gly Asn His Pro Ile Tyr Leu Asp Thr Arg Tyr Phe Thr Lys 
225                 230                 235                 240 


Asp Glu Ser Gly Lys Leu Ser Tyr Val Ser Asp Pro Ala Asp Lys Asn 
                245                 250                 255     


Ala Lys Tyr Val Ser Tyr Thr Asn Gly Val Phe Leu Arg Asn Ala His 
            260                 265                 270         


Ala Gln Glu Val Leu Leu Arg Pro Glu Gly Ile Thr Trp Arg Thr Leu 
        275                 280                 285             


Gly Gly Ser Ile Asp Leu Tyr Phe Phe Glu Gly Pro Phe Ala Gln Asp 
    290                 295                 300                 


Ile Ile Lys Ser Tyr Gln Leu Ser Thr Val Gly Leu Pro Ala Met Gln 
305                 310                 315                 320 


Gln Tyr Trp Thr Leu Gly Phe His Gln Cys Arg Trp Gly Tyr Ser Asn 
                325                 330                 335     


Trp Thr Val Val Lys Asp Val Val Asp Asn Phe Arg Lys Phe Gly Ile 
            340                 345                 350         


Pro Leu Glu Thr Ile Trp Thr Asp Ile Asp Tyr Met Lys Gly Tyr Arg 
        355                 360                 365             


Asp Phe Glu Asn Asp Pro Asp Gln Phe Ser Tyr Glu Glu Gly Ala Arg 
    370                 375                 380                 


Phe Leu Glu Glu Leu His Lys Asn His Gln His Tyr Val Pro Ile Val 
385                 390                 395                 400 


Asp Ser Ala Ile Tyr Val Pro Asn Pro Asp Lys Pro Glu Asp Asp Tyr 
                405                 410                 415     


Glu Pro Tyr His Arg Gly Leu Glu Ala Asp Ala Phe Ile Met Asn Pro 
            420                 425                 430         


Asp Gly Ser Leu Tyr Ile Gly Ala Val Trp Pro Gly Tyr Thr Val Phe 
        435                 440                 445             


Pro Asp Trp Ile Gly Ala Ala Leu Asn Gly Thr Gly Thr Val Gly Trp 
    450                 455                 460                 


Trp Thr Asp Glu Phe Val Arg Tyr Tyr Lys Lys Val Ala Phe Asp Gly 
465                 470                 475                 480 


Ile Trp Ile Asp Met Ser Glu Val Ala Ser Phe Cys Ile Gly Ser Cys 
                485                 490                 495     


Gly Thr Gly Asn Leu Thr Leu Asn Pro Val His Pro Pro Trp Gly Leu 
            500                 505                 510         


Pro Gly Glu Pro Gly Ala Leu Val Leu Asp Tyr Pro Glu Gly Phe Glu 
        515                 520                 525             


Lys Thr Asn Ala Ser Glu Ala Ser Ser Ala Thr Ser Val Tyr Lys Thr 
    530                 535                 540                 


Gln Asn Pro Asp Pro Thr Thr Thr Ala Ser Thr Thr Ser Thr Thr Ser 
545                 550                 555                 560 


Tyr Leu Arg Thr Thr Pro Thr Pro Gly Val Arg Asn Ile Asn Tyr Pro 
                565                 570                 575     


Pro Tyr Val Ile Asn Asn Phe His Gly Asp Ile Gly Thr His Ala Leu 
            580                 585                 590         


Ser Pro Asn Gly Thr His His Gly Gly Thr Val Asp Tyr Asp Phe His 
        595                 600                 605             


Asn Leu Phe Gly His Gln Ile Leu His Ala Thr Tyr Gln Ala Leu Leu 
    610                 615                 620                 


Lys Val Phe Glu Gly Lys Arg Pro Phe Ile Ile Gly Arg Ser Thr Phe 
625                 630                 635                 640 


Ala Gly Ser Gly Lys Trp Ala Gly His Trp Gly Gly Asp Asn Tyr Ser 
                645                 650                 655     


Leu Trp Ala Phe Leu Tyr Phe Ser Ile Pro Gln Ala Leu Ser Phe Ser 
            660                 665                 670         


Ile Phe Gly Phe Pro Met Phe Gly Val Asp Thr Cys Gly Phe Asn Gly 
        675                 680                 685             


Asn Thr Asp His Glu Leu Cys Ser Arg Trp Met Gln Leu Ser Ala Phe 
    690                 695                 700                 


Phe Pro Phe Tyr Arg Asn His Asn Val Arg Gly Ala Ile Ser Gln Glu 
705                 710                 715                 720 


Pro Tyr Val Trp Ser Ser Val Ile Asp Ala Ser Lys Lys Ala Met Arg 
                725                 730                 735     


Ile Arg Tyr Leu Leu Leu Pro Tyr Met Tyr Thr Leu Met Ala Gln Ala 
            740                 745                 750         


Ser Leu Ser Gly Asp Thr Val Met Arg Ala Leu Ser Trp Glu Phe Pro 
        755                 760                 765             


Gln Glu Pro Trp Leu Ala Asp Ala Asp Arg Gln Phe Met Leu Gly Ser 
    770                 775                 780                 


Ala Val Met Val Thr Pro Cys Leu Val Gln Gly Ala Asn Thr Val Asp 
785                 790                 795                 800 


Gly Val Phe Pro Gly Val Gly Asp Gly Thr Ile Trp Tyr Asp Trp Tyr 
                805                 810                 815     


Thr Tyr Lys Ala Ala Ser Glu Gly Val Gln Pro Gly Glu Asn Val Thr 
            820                 825                 830         


Ile Asp Ala Pro Leu Gly His Ile Pro Val Phe Leu Arg Gly Gly His 
        835                 840                 845             


Val Ile Pro Val Gln Glu Pro Gly Met Thr Thr Thr Glu Ser Arg Gln 
    850                 855                 860                 


Asn Glu Trp Ser Val Ile Val Ala Leu Asp Gly Ala Gly Lys Ala Asn 
865                 870                 875                 880 


Gly Thr Leu Tyr Leu Asp Asp Gly Glu Ser Leu Glu Pro Gly Glu Asn 
                885                 890                 895     


Val Lys Trp Val Asp Phe Thr Val Glu Lys Asn Ser Phe Arg Val Thr 
            900                 905                 910         


Pro Gln Gly Lys Tyr Leu Asp Arg Asn Ser Leu Ala Asn Val Thr Ile 
        915                 920                 925             


Leu Gly Val Ala Glu Ala Pro Leu Gly Val Ala Ile Asn Ser His Leu 
    930                 935                 940                 


Leu Gly Ser Ala Ser Trp Ser Tyr Asp Ser Glu Gly Lys Phe Leu Ser 
945                 950                 955                 960 


Val Thr Glu Leu Gln Asp Asn Phe Lys Glu Gly Ala Trp Ala Ser Asn 
                965                 970                 975     


Trp Thr Leu Ser Trp Asn Ser Ala Ser Asn Ser Gly Ser Ser Pro Val 
            980                 985                 990         


Gln Gly Gly Gly Gly Arg Leu Glu  Phe Ser Thr Pro Asn  Leu Leu His 
        995                 1000                 1005             


Ala Ala  Ala Phe Gly Ile Leu  Phe Gly Arg Met Phe  Val Val 
    1010                 1015                 1020         


<210>  13
<211>  3293
<212>  DNA
<213>  Rasamsonia composticola

<400>  13
atgcggccaa cttccctcgt caagcacttg gctgcgacca gcctcctctt tctcgcggcg       60

gatgcagctg ctatcgtccg ccgcaacggc gcctctcctt catgccccgg ctataaagcg      120

agtaacgtga agaccgtcga cggtgaaatc gtcagcgcgg atctcaatct cgcgggtccc      180

gcctgcaatg tgtatggcac ggatctggac gatctgaagc tgcaggttga gtaccaatca      240

ggtaagtcgc acagcatcgc cgtctgcagc ttatcggcag catgtgatcg gcgcctggac      300

tagggcttag ggcctggggt tagggctgac tgcttgctgc cgttcgatgt gactggaact      360

gtacggttgg ttgacaacga tctgacatct gcagaacaac gcctccatgt gaagatctac      420

gatgccgccg agcaggtcta ccaggtgccc accgcggtgc ttccccggcc cagcagcgcc      480

aacatccccc cggccaagtc ggacctgaag ttctccatga ccaacgaccc cttctccttt      540

accatcaagc gcagatcaaa cggcgaaatc ctcttcgaca cctccggcca tccgctgatc      600

ttcgagtcgc agtatctggg cctccgtacc aagctgccgg actcgcccaa catctacggc      660

ctgggagagc acaccggttc tttccgcctg cccaccaaga attacacccg cacgctgtgg      720

tcgcgcgatg cgtacggtac gcccaaagac accaacctgt acggcaacca cccggtgtac      780

ttcgactacc gcggcagcaa cggcacccat ggcgtgttcc tgctgaacag caacggcatg      840

gacgtcgata tcgacgtcga ctcggacgga cagtacctgc agtacaacac cctggggggc      900

gtgctggact tctacttcct cagcgggccg gatcccaagg ccgtcgcgac gcagtatgcc      960

gagacggtcg gaaaaccggt catgatgccc tactggggat tcggcttcca caactgcaga     1020

tatggatacc aggacatcta tgaggttgct gagatcattg ccaactacag tgccgcaaac     1080

attccgcttg agacccaatg gactgatatc ggtatgcttt ccatcccggt gccgtggttt     1140

ttgcttctca gcgtggctga ctgttgcaga ctatatggat ctgaggaaag tgtttacgct     1200

ggacccctat cgctatccat tgaagctcgt ccaagaggtt gtctcttatc tccacaagca     1260

caaccagcac tacatcatga tggtggaccc tgcagtggca taccagaact attcagcgtt     1320

caacaacggc gtcgctgccg acgctttcct gaagttctcg aatggctcca tctaccaggg     1380

tgtcgtctgg ccggggccga cggcgttccc ggactggttc gcaccccaga cacaggagtt     1440

ttggaatagc gagttctcga ccttctttga ccccgcccac ggcgtcgaca tcgatgccct     1500

ttggatcgac atgaacgagg cgtccaactt ctgcgacttt ccctgctcga accccgccgc     1560

gtatgcggca gccaacggcg atccgcccac gcctccgccg gtccgcttga gccccccgag     1620

gccgattcct ggatttggcc ctgacttcca gccgacgtgt gtcgccacgg tgtcgttcga     1680

ttgcgatgcg cagacctact ttggcgagaa catcctcatc ctgggtaact cgacgacact     1740

gggagccggc gacgttcaca tggcgccagt catgagcgcg aacaactacc cgatctggca     1800

gctgaccgtc cagatgccgc cgaatgggac gttctcgtac cagtacgttc gcaaggaatc     1860

ggacggcagt tacatctacg aacagacgaa tcgcacggtc acgacgggcg actgcaccag     1920

cggcacgctt aaggtgtccg acaccatcac caccagctct ggaccgcaca agagatccga     1980

attacggccg ctggtgcgct cgccgttccc ggcggaggac ctgaccaggc gccagtctgg     2040

atcgatgttg ggcctgccca acaggaacct gctgaatccg ccatacacca tccacaatgc     2100

ggctggcaac ctgagtgaga agaccatcaa caccgacctg atccatgcgg gcggatatgc     2160

cgagtacgac acgcacaact tgtacggcac gatgatgagc gcgaccagca gggaggcgat     2220

gctgaaccgc agaccagcag tcaggccact tgtgtaagtc atccatcgtc cttaagccag     2280

acacagcatg ttaggggcta acgggcagta gcattacccg gtcgaccttc gctggagccg     2340

gccgacaggt cggccactgg ctcggcgaca atttcgccga ttgggaccac taccggtgga     2400

cgatcgccga gctgcaggaa ttcgcggcgc tgttccagat cccgatggtc ggcagcgaca     2460

tctgcgggta cgacggcaac acgacggaca acctgtgctc gcgctgggtc ttcctcggcg     2520

ccttctcgcc cttcttccgc gaccactcgg acaaccagtc gccgccgcac gagctgtacc     2580

gcactccgca gatcgcggcg gccgcgcgcg ccgccatcga catccgctac cgtctgctcg     2640

actacgcgta cacggtgctg tggacgcaga cccagaccgg cgcgccgatg ctcaacccca     2700

tgttcttcga gtacccggcc gacagcaaca ccgccgacct gcagtaccag ttcttctggg     2760

gcgacagcat catggtcgcg cccgtgaccg acaacgactc gaccaccgtc aacgtctact     2820

tcccgaagga ccagttctac gacttctaca ccggcgcacc tgtgtccggg gagggcaata     2880

ccgtcaccct gaccgacgtc ggcttcgaca ccatcccgct gtacttcaag ggcgggagca     2940

tcgtgcccat gcgcgtgcgc tcggcgaaca cgacggcgga gctgcggcag caggacttcg     3000

tcgtcgtcat cgccccggac agccacggcg acgcgacggg ccagctgtac ctcgacgacg     3060

gcgagagcat caaccagccg cacaccagcg agatccagtt ctcgtaccgc ggaggccatt     3120

tcagcatgac aggcaagttt gactatgatc ccggcaacgt ggtcatcagc cagatcacgc     3180

tgctgggtgc ggacggcgcc ggtaaagggg gttcgtataa cagcaccacc aaggtggcga     3240

cctacaaagt caacgcgaag ttgacgggta aattcgaagc cagcttacac taa            3293


<210>  14
<211>  1035
<212>  PRT
<213>  Rasamsonia composticola

<400>  14

Met Arg Pro Thr Ser Leu Val Lys His Leu Ala Ala Thr Ser Leu Leu 
1               5                   10                  15      


Phe Leu Ala Ala Asp Ala Ala Ala Ile Val Arg Arg Asn Gly Ala Ser 
            20                  25                  30          


Pro Ser Cys Pro Gly Tyr Lys Ala Ser Asn Val Lys Thr Val Asp Gly 
        35                  40                  45              


Glu Ile Val Ser Ala Asp Leu Asn Leu Ala Gly Pro Ala Cys Asn Val 
    50                  55                  60                  


Tyr Gly Thr Asp Leu Asp Asp Leu Lys Leu Gln Val Glu Tyr Gln Ser 
65                  70                  75                  80  


Gly Pro Gly Val Arg Ala Asp Cys Leu Leu Pro Phe Asp Val Thr Gly 
                85                  90                  95      


Thr Val Arg Leu Val Asp Asn Asp Leu Thr Ser Ala Glu Gln Arg Leu 
            100                 105                 110         


His Val Lys Ile Tyr Asp Ala Ala Glu Gln Val Tyr Gln Val Pro Thr 
        115                 120                 125             


Ala Val Leu Pro Arg Pro Ser Ser Ala Asn Ile Pro Pro Ala Lys Ser 
    130                 135                 140                 


Asp Leu Lys Phe Ser Met Thr Asn Asp Pro Phe Ser Phe Thr Ile Lys 
145                 150                 155                 160 


Arg Arg Ser Asn Gly Glu Ile Leu Phe Asp Thr Ser Gly His Pro Leu 
                165                 170                 175     


Ile Phe Glu Ser Gln Tyr Leu Gly Leu Arg Thr Lys Leu Pro Asp Ser 
            180                 185                 190         


Pro Asn Ile Tyr Gly Leu Gly Glu His Thr Gly Ser Phe Arg Leu Pro 
        195                 200                 205             


Thr Lys Asn Tyr Thr Arg Thr Leu Trp Ser Arg Asp Ala Tyr Gly Thr 
    210                 215                 220                 


Pro Lys Asp Thr Asn Leu Tyr Gly Asn His Pro Val Tyr Phe Asp Tyr 
225                 230                 235                 240 


Arg Gly Ser Asn Gly Thr His Gly Val Phe Leu Leu Asn Ser Asn Gly 
                245                 250                 255     


Met Asp Val Asp Ile Asp Val Asp Ser Asp Gly Gln Tyr Leu Gln Tyr 
            260                 265                 270         


Asn Thr Leu Gly Gly Val Leu Asp Phe Tyr Phe Leu Ser Gly Pro Asp 
        275                 280                 285             


Pro Lys Ala Val Ala Thr Gln Tyr Ala Glu Thr Val Gly Lys Pro Val 
    290                 295                 300                 


Met Met Pro Tyr Trp Gly Phe Gly Phe His Asn Cys Arg Tyr Gly Tyr 
305                 310                 315                 320 


Gln Asp Ile Tyr Glu Val Ala Glu Ile Ile Ala Asn Tyr Ser Ala Ala 
                325                 330                 335     


Asn Ile Pro Leu Glu Thr Gln Trp Thr Asp Ile Asp Tyr Met Asp Leu 
            340                 345                 350         


Arg Lys Val Phe Thr Leu Asp Pro Tyr Arg Tyr Pro Leu Lys Leu Val 
        355                 360                 365             


Gln Glu Val Val Ser Tyr Leu His Lys His Asn Gln His Tyr Ile Met 
    370                 375                 380                 


Met Val Asp Pro Ala Val Ala Tyr Gln Asn Tyr Ser Ala Phe Asn Asn 
385                 390                 395                 400 


Gly Val Ala Ala Asp Ala Phe Leu Lys Phe Ser Asn Gly Ser Ile Tyr 
                405                 410                 415     


Gln Gly Val Val Trp Pro Gly Pro Thr Ala Phe Pro Asp Trp Phe Ala 
            420                 425                 430         


Pro Gln Thr Gln Glu Phe Trp Asn Ser Glu Phe Ser Thr Phe Phe Asp 
        435                 440                 445             


Pro Ala His Gly Val Asp Ile Asp Ala Leu Trp Ile Asp Met Asn Glu 
    450                 455                 460                 


Ala Ser Asn Phe Cys Asp Phe Pro Cys Ser Asn Pro Ala Ala Tyr Ala 
465                 470                 475                 480 


Ala Ala Asn Gly Asp Pro Pro Thr Pro Pro Pro Val Arg Leu Ser Pro 
                485                 490                 495     


Pro Arg Pro Ile Pro Gly Phe Gly Pro Asp Phe Gln Pro Thr Cys Val 
            500                 505                 510         


Ala Thr Val Ser Phe Asp Cys Asp Ala Gln Thr Tyr Phe Gly Glu Asn 
        515                 520                 525             


Ile Leu Ile Leu Gly Asn Ser Thr Thr Leu Gly Ala Gly Asp Val His 
    530                 535                 540                 


Met Ala Pro Val Met Ser Ala Asn Asn Tyr Pro Ile Trp Gln Leu Thr 
545                 550                 555                 560 


Val Gln Met Pro Pro Asn Gly Thr Phe Ser Tyr Gln Tyr Val Arg Lys 
                565                 570                 575     


Glu Ser Asp Gly Ser Tyr Ile Tyr Glu Gln Thr Asn Arg Thr Val Thr 
            580                 585                 590         


Thr Gly Asp Cys Thr Ser Gly Thr Leu Lys Val Ser Asp Thr Ile Thr 
        595                 600                 605             


Thr Ser Ser Gly Pro His Lys Arg Ser Glu Leu Arg Pro Leu Val Arg 
    610                 615                 620                 


Ser Pro Phe Pro Ala Glu Asp Leu Thr Arg Arg Gln Ser Gly Ser Met 
625                 630                 635                 640 


Leu Gly Leu Pro Asn Arg Asn Leu Leu Asn Pro Pro Tyr Thr Ile His 
                645                 650                 655     


Asn Ala Ala Gly Asn Leu Ser Glu Lys Thr Ile Asn Thr Asp Leu Ile 
            660                 665                 670         


His Ala Gly Gly Tyr Ala Glu Tyr Asp Thr His Asn Leu Tyr Gly Thr 
        675                 680                 685             


Met Met Ser Ala Thr Ser Arg Glu Ala Met Leu Asn Arg Arg Pro Ala 
    690                 695                 700                 


Val Arg Pro Leu Val Ile Thr Arg Ser Thr Phe Ala Gly Ala Gly Arg 
705                 710                 715                 720 


Gln Val Gly His Trp Leu Gly Asp Asn Phe Ala Asp Trp Asp His Tyr 
                725                 730                 735     


Arg Trp Thr Ile Ala Glu Leu Gln Glu Phe Ala Ala Leu Phe Gln Ile 
            740                 745                 750         


Pro Met Val Gly Ser Asp Ile Cys Gly Tyr Asp Gly Asn Thr Thr Asp 
        755                 760                 765             


Asn Leu Cys Ser Arg Trp Val Phe Leu Gly Ala Phe Ser Pro Phe Phe 
    770                 775                 780                 


Arg Asp His Ser Asp Asn Gln Ser Pro Pro His Glu Leu Tyr Arg Thr 
785                 790                 795                 800 


Pro Gln Ile Ala Ala Ala Ala Arg Ala Ala Ile Asp Ile Arg Tyr Arg 
                805                 810                 815     


Leu Leu Asp Tyr Ala Tyr Thr Val Leu Trp Thr Gln Thr Gln Thr Gly 
            820                 825                 830         


Ala Pro Met Leu Asn Pro Met Phe Phe Glu Tyr Pro Ala Asp Ser Asn 
        835                 840                 845             


Thr Ala Asp Leu Gln Tyr Gln Phe Phe Trp Gly Asp Ser Ile Met Val 
    850                 855                 860                 


Ala Pro Val Thr Asp Asn Asp Ser Thr Thr Val Asn Val Tyr Phe Pro 
865                 870                 875                 880 


Lys Asp Gln Phe Tyr Asp Phe Tyr Thr Gly Ala Pro Val Ser Gly Glu 
                885                 890                 895     


Gly Asn Thr Val Thr Leu Thr Asp Val Gly Phe Asp Thr Ile Pro Leu 
            900                 905                 910         


Tyr Phe Lys Gly Gly Ser Ile Val Pro Met Arg Val Arg Ser Ala Asn 
        915                 920                 925             


Thr Thr Ala Glu Leu Arg Gln Gln Asp Phe Val Val Val Ile Ala Pro 
    930                 935                 940                 


Asp Ser His Gly Asp Ala Thr Gly Gln Leu Tyr Leu Asp Asp Gly Glu 
945                 950                 955                 960 


Ser Ile Asn Gln Pro His Thr Ser Glu Ile Gln Phe Ser Tyr Arg Gly 
                965                 970                 975     


Gly His Phe Ser Met Thr Gly Lys Phe Asp Tyr Asp Pro Gly Asn Val 
            980                 985                 990         


Val Ile Ser Gln Ile Thr Leu Leu  Gly Ala Asp Gly Ala  Gly Lys Gly 
        995                 1000                 1005             


Gly Ser  Tyr Asn Ser Thr Thr  Lys Val Ala Thr Tyr  Lys Val Asn 
    1010                 1015                 1020             


Ala Lys  Leu Thr Gly Lys Phe  Glu Ala Ser Leu His  
    1025                 1030                 1035 


<210>  15
<211>  1013
<212>  PRT
<213>  Rasamsonia composticola

<400>  15

Ala Ala Ile Val Arg Arg Asn Gly Ala Ser Pro Ser Cys Pro Gly Tyr 
1               5                   10                  15      


Lys Ala Ser Asn Val Lys Thr Val Asp Gly Glu Ile Val Ser Ala Asp 
            20                  25                  30          


Leu Asn Leu Ala Gly Pro Ala Cys Asn Val Tyr Gly Thr Asp Leu Asp 
        35                  40                  45              


Asp Leu Lys Leu Gln Val Glu Tyr Gln Ser Gly Pro Gly Val Arg Ala 
    50                  55                  60                  


Asp Cys Leu Leu Pro Phe Asp Val Thr Gly Thr Val Arg Leu Val Asp 
65                  70                  75                  80  


Asn Asp Leu Thr Ser Ala Glu Gln Arg Leu His Val Lys Ile Tyr Asp 
                85                  90                  95      


Ala Ala Glu Gln Val Tyr Gln Val Pro Thr Ala Val Leu Pro Arg Pro 
            100                 105                 110         


Ser Ser Ala Asn Ile Pro Pro Ala Lys Ser Asp Leu Lys Phe Ser Met 
        115                 120                 125             


Thr Asn Asp Pro Phe Ser Phe Thr Ile Lys Arg Arg Ser Asn Gly Glu 
    130                 135                 140                 


Ile Leu Phe Asp Thr Ser Gly His Pro Leu Ile Phe Glu Ser Gln Tyr 
145                 150                 155                 160 


Leu Gly Leu Arg Thr Lys Leu Pro Asp Ser Pro Asn Ile Tyr Gly Leu 
                165                 170                 175     


Gly Glu His Thr Gly Ser Phe Arg Leu Pro Thr Lys Asn Tyr Thr Arg 
            180                 185                 190         


Thr Leu Trp Ser Arg Asp Ala Tyr Gly Thr Pro Lys Asp Thr Asn Leu 
        195                 200                 205             


Tyr Gly Asn His Pro Val Tyr Phe Asp Tyr Arg Gly Ser Asn Gly Thr 
    210                 215                 220                 


His Gly Val Phe Leu Leu Asn Ser Asn Gly Met Asp Val Asp Ile Asp 
225                 230                 235                 240 


Val Asp Ser Asp Gly Gln Tyr Leu Gln Tyr Asn Thr Leu Gly Gly Val 
                245                 250                 255     


Leu Asp Phe Tyr Phe Leu Ser Gly Pro Asp Pro Lys Ala Val Ala Thr 
            260                 265                 270         


Gln Tyr Ala Glu Thr Val Gly Lys Pro Val Met Met Pro Tyr Trp Gly 
        275                 280                 285             


Phe Gly Phe His Asn Cys Arg Tyr Gly Tyr Gln Asp Ile Tyr Glu Val 
    290                 295                 300                 


Ala Glu Ile Ile Ala Asn Tyr Ser Ala Ala Asn Ile Pro Leu Glu Thr 
305                 310                 315                 320 


Gln Trp Thr Asp Ile Asp Tyr Met Asp Leu Arg Lys Val Phe Thr Leu 
                325                 330                 335     


Asp Pro Tyr Arg Tyr Pro Leu Lys Leu Val Gln Glu Val Val Ser Tyr 
            340                 345                 350         


Leu His Lys His Asn Gln His Tyr Ile Met Met Val Asp Pro Ala Val 
        355                 360                 365             


Ala Tyr Gln Asn Tyr Ser Ala Phe Asn Asn Gly Val Ala Ala Asp Ala 
    370                 375                 380                 


Phe Leu Lys Phe Ser Asn Gly Ser Ile Tyr Gln Gly Val Val Trp Pro 
385                 390                 395                 400 


Gly Pro Thr Ala Phe Pro Asp Trp Phe Ala Pro Gln Thr Gln Glu Phe 
                405                 410                 415     


Trp Asn Ser Glu Phe Ser Thr Phe Phe Asp Pro Ala His Gly Val Asp 
            420                 425                 430         


Ile Asp Ala Leu Trp Ile Asp Met Asn Glu Ala Ser Asn Phe Cys Asp 
        435                 440                 445             


Phe Pro Cys Ser Asn Pro Ala Ala Tyr Ala Ala Ala Asn Gly Asp Pro 
    450                 455                 460                 


Pro Thr Pro Pro Pro Val Arg Leu Ser Pro Pro Arg Pro Ile Pro Gly 
465                 470                 475                 480 


Phe Gly Pro Asp Phe Gln Pro Thr Cys Val Ala Thr Val Ser Phe Asp 
                485                 490                 495     


Cys Asp Ala Gln Thr Tyr Phe Gly Glu Asn Ile Leu Ile Leu Gly Asn 
            500                 505                 510         


Ser Thr Thr Leu Gly Ala Gly Asp Val His Met Ala Pro Val Met Ser 
        515                 520                 525             


Ala Asn Asn Tyr Pro Ile Trp Gln Leu Thr Val Gln Met Pro Pro Asn 
    530                 535                 540                 


Gly Thr Phe Ser Tyr Gln Tyr Val Arg Lys Glu Ser Asp Gly Ser Tyr 
545                 550                 555                 560 


Ile Tyr Glu Gln Thr Asn Arg Thr Val Thr Thr Gly Asp Cys Thr Ser 
                565                 570                 575     


Gly Thr Leu Lys Val Ser Asp Thr Ile Thr Thr Ser Ser Gly Pro His 
            580                 585                 590         


Lys Arg Ser Glu Leu Arg Pro Leu Val Arg Ser Pro Phe Pro Ala Glu 
        595                 600                 605             


Asp Leu Thr Arg Arg Gln Ser Gly Ser Met Leu Gly Leu Pro Asn Arg 
    610                 615                 620                 


Asn Leu Leu Asn Pro Pro Tyr Thr Ile His Asn Ala Ala Gly Asn Leu 
625                 630                 635                 640 


Ser Glu Lys Thr Ile Asn Thr Asp Leu Ile His Ala Gly Gly Tyr Ala 
                645                 650                 655     


Glu Tyr Asp Thr His Asn Leu Tyr Gly Thr Met Met Ser Ala Thr Ser 
            660                 665                 670         


Arg Glu Ala Met Leu Asn Arg Arg Pro Ala Val Arg Pro Leu Val Ile 
        675                 680                 685             


Thr Arg Ser Thr Phe Ala Gly Ala Gly Arg Gln Val Gly His Trp Leu 
    690                 695                 700                 


Gly Asp Asn Phe Ala Asp Trp Asp His Tyr Arg Trp Thr Ile Ala Glu 
705                 710                 715                 720 


Leu Gln Glu Phe Ala Ala Leu Phe Gln Ile Pro Met Val Gly Ser Asp 
                725                 730                 735     


Ile Cys Gly Tyr Asp Gly Asn Thr Thr Asp Asn Leu Cys Ser Arg Trp 
            740                 745                 750         


Val Phe Leu Gly Ala Phe Ser Pro Phe Phe Arg Asp His Ser Asp Asn 
        755                 760                 765             


Gln Ser Pro Pro His Glu Leu Tyr Arg Thr Pro Gln Ile Ala Ala Ala 
    770                 775                 780                 


Ala Arg Ala Ala Ile Asp Ile Arg Tyr Arg Leu Leu Asp Tyr Ala Tyr 
785                 790                 795                 800 


Thr Val Leu Trp Thr Gln Thr Gln Thr Gly Ala Pro Met Leu Asn Pro 
                805                 810                 815     


Met Phe Phe Glu Tyr Pro Ala Asp Ser Asn Thr Ala Asp Leu Gln Tyr 
            820                 825                 830         


Gln Phe Phe Trp Gly Asp Ser Ile Met Val Ala Pro Val Thr Asp Asn 
        835                 840                 845             


Asp Ser Thr Thr Val Asn Val Tyr Phe Pro Lys Asp Gln Phe Tyr Asp 
    850                 855                 860                 


Phe Tyr Thr Gly Ala Pro Val Ser Gly Glu Gly Asn Thr Val Thr Leu 
865                 870                 875                 880 


Thr Asp Val Gly Phe Asp Thr Ile Pro Leu Tyr Phe Lys Gly Gly Ser 
                885                 890                 895     


Ile Val Pro Met Arg Val Arg Ser Ala Asn Thr Thr Ala Glu Leu Arg 
            900                 905                 910         


Gln Gln Asp Phe Val Val Val Ile Ala Pro Asp Ser His Gly Asp Ala 
        915                 920                 925             


Thr Gly Gln Leu Tyr Leu Asp Asp Gly Glu Ser Ile Asn Gln Pro His 
    930                 935                 940                 


Thr Ser Glu Ile Gln Phe Ser Tyr Arg Gly Gly His Phe Ser Met Thr 
945                 950                 955                 960 


Gly Lys Phe Asp Tyr Asp Pro Gly Asn Val Val Ile Ser Gln Ile Thr 
                965                 970                 975     


Leu Leu Gly Ala Asp Gly Ala Gly Lys Gly Gly Ser Tyr Asn Ser Thr 
            980                 985                 990         


Thr Lys Val Ala Thr Tyr Lys Val  Asn Ala Lys Leu Thr  Gly Lys Phe 
        995                 1000                 1005             


Glu Ala  Ser Leu His 
    1010             


<210>  16
<211>  3162
<212>  DNA
<213>  Rasamsonia composticola

<400>  16
atggcaggct ccgccgccct tgttgccagc ctcgtctggc ttgctcaggc cttcgacgct       60

cttgcaggac cggtcagcag tacgactgcc gcagcaccat ctgctcaatt caccgtcccg      120

gccgctgcgg atgttggggc caacttgctt gccaacatcg acgatcccaa tgccgtcaac      180

gcccaggatg tctgtcccgg ttacacggcg tcgaacgtgc agaacaccga gtctgggttt      240

gtggcgaccc tgacgctggc ggggaaacca tgtaatgtgt acggaacgga cgtggagtcc      300

ctgaacctga cggttgagta ccaagctgcg gatcgactga acatcaatat cgtcccgacg      360

cacgtcgatt cttcaaacca gtcgtggtat ctgcttcccg aaaatgtagt gcccaaaccg      420

ggggtcgatg caggagccca agtcccggag agtgatctcg tcttcagctg gtcgaatgaa      480

ccctccttca atttcaaggt gatccggaaa gccacaggcg acattctctt cgacacggag      540

ggttctgtcc tggtgttcga aaaccagttc atcgagtttg cgagcgctct gccggagaac      600

tacaatctct acggtctggg agagcgtatc catggcctgc gactggggaa caacttcacc      660

gccacgacgt atgccgcgga tagcgcagac cctattgacc ggtgagtatc tgagatcgac      720

tgctcagtct gctctgttgg atctgaaaga agttataaaa ctgacctagc tcaggaacat      780

ctacgggacc catccctttt atctggacac ccggtactac gaggttgatt ccgagcatgg      840

gaggttcacg ttggtgacgg acaacgagac cgatttctcc aaggaatatc tgtcgctctc      900

gcatggagtt ttcctgagaa atgcccacgg acaggaggtg ctgctgcgtc ctcagagcat      960

cacctggcgg acactcggtg gcagcattga tctttacttc tacgccggtc cgacccaggc     1020

cgatgttacc cgcagctacc agaccagcac cgttggcctc ccggcaatgc agcagtactt     1080

caccctgggc tatcatcagt gccgctgggg atacagaaac tggtcggagc tagctgatgt     1140

agtggccaat ttcgagaaat tcgagatccc attggaaaat atctggtaag gcatacgcta     1200

tctgaaagag ttgctgggaa agtgatctga caacttcgtc tctccaggtc ggatattgat     1260

tacatgaacg agtaccgcga ctttgagaac gacccggttc gcttctccta cagcgaggga     1320

gccaaattcc tggaccagct ccacaagagt ggccgtcact acatcccgat tgtggacgcc     1380

gcgatctatg accccaaccc taacaatgac tccgacgcgt aagtctagtc ttgtagggag     1440

gtgataggga gtggagctga cttctcgatt aggtatgcga catatgatcg aggttctaag     1500

gacgatatct ggttgaagaa tcccgacggc agcgtgtaca tcggagccgt ctggcctggc     1560

tacacagtgt tcaccgattg gcaccatcca aaagccaacg agtggtgggc aaacgagctg     1620

gctctgtggc acgaaaaggt cgcttttgac ggaatctggc tggacatgaa cgaggtctcg     1680

tccttctgcg ttggcagctg tggaacaggg aacctgaccc tgaatcccgt gcacccgaac     1740

ttcgcgctcc cgggagagcc tggagctgtc atctacgact accccgagga cttcaacgtg     1800

acgaatgcca cggcggcggc gtctgcatct gccgcgtcct cgagccaagc tgctgcgaca     1860

gcgacagcta cttcttcgtc cacgactacc agctacctgg tgaccacgcc cactcctgga     1920

gtgcggaatg tcaactaccc tccctatgtg attaatcacg tgcaggaggg tcacgatctc     1980

gctgttcacg ccgtctcgcc caacgcaacc catgtcgatg gtgtgcagga gtacgacgtg     2040

cacaatctct ggggctacca ggagacaaat gcaacctacc atgccctgct gagcatcttc     2100

cccgggaaga gaccgttcat catctcccgt tccacgttcg ccggcagcgg cagatgggcc     2160

ggacactggg gtggcgacaa cgcctcgaaa tgggcgtaca tgttcttttc tatcccgcag     2220

gcgctatcgt tctcgctgtt cggcatcccc atgttcggcg tcgacacctg cgggttcaac     2280

ggcaactcgg acgaagagct gtgcaaccgc tggatgcagc tctccgcctt cttccccttc     2340

taccgcaacc acaacgtcct gtcggccatc ccgcaggagc cctatgtctg ggcatccgtc     2400

atcgaggcga gcaagtcggc aatgaggatc cgctacaccc tgctccctta cctctacaca     2460

ctgttctacc tcgcccacac cacggggtcg accgtcatgc gtgccttggc gtgggagttc     2520

cccaacgacc cgtccctcgc tgccgtggac cggcagttcc tcctgggccc gtcgctgatg     2580

gtcgtccccg tgctcgagcc gcaggtcgat accgtcaagg gcgtcttccc gggcgttgcc     2640

cagggccaag tctggtacga ctggtacacg cagaccgcgt tcgacgcgca gccaggcgtg     2700

aacacgacca tctccgcgcc gctgggccac atccccgtgt tcgtccgcgg cgggagcgtg     2760

ctccccatgc agcagccggc actggtgacg cgggacgtgc gcaacagccc ctggtcgctg     2820

ctggtcgcgc tgggcagcga cggcacggcc tcgggacagc tgtacgtgga cgacggcgag     2880

agcatcacac ctccggcgtc cctgcacgtc gacttcgtgg cggccaactt ctcgaccctc     2940

ttcgcgacgg cccgcggtgc gttcaaggac agcaacacgc tggctaacgt cacggtgctg     3000

ggcgtcccag ccgcgccgtc gtctgcagtc acttggaaca acgagacggt tccttcggag     3060

tcggtgtcgt acaatgccac ctccaaagtc ctcgtggtca atggactgca gagtcttacc     3120

cgtgacggag cctggagcag tgactgggtt ctgaagtggt aa                        3162


<210>  17
<211>  990
<212>  PRT
<213>  Rasamsonia composticola

<400>  17

Met Ala Gly Ser Ala Ala Leu Val Ala Ser Leu Val Trp Leu Ala Gln 
1               5                   10                  15      


Ala Phe Asp Ala Leu Ala Gly Pro Val Ser Ser Thr Thr Ala Ala Ala 
            20                  25                  30          


Pro Ser Ala Gln Phe Thr Val Pro Ala Ala Ala Asp Val Gly Ala Asn 
        35                  40                  45              


Leu Leu Ala Asn Ile Asp Asp Pro Asn Ala Val Asn Ala Gln Asp Val 
    50                  55                  60                  


Cys Pro Gly Tyr Thr Ala Ser Asn Val Gln Asn Thr Glu Ser Gly Phe 
65                  70                  75                  80  


Val Ala Thr Leu Thr Leu Ala Gly Lys Pro Cys Asn Val Tyr Gly Thr 
                85                  90                  95      


Asp Val Glu Ser Leu Asn Leu Thr Val Glu Tyr Gln Ala Ala Asp Arg 
            100                 105                 110         


Leu Asn Ile Asn Ile Val Pro Thr His Val Asp Ser Ser Asn Gln Ser 
        115                 120                 125             


Trp Tyr Leu Leu Pro Glu Asn Val Val Pro Lys Pro Gly Val Asp Ala 
    130                 135                 140                 


Gly Ala Gln Val Pro Glu Ser Asp Leu Val Phe Ser Trp Ser Asn Glu 
145                 150                 155                 160 


Pro Ser Phe Asn Phe Lys Val Ile Arg Lys Ala Thr Gly Asp Ile Leu 
                165                 170                 175     


Phe Asp Thr Glu Gly Ser Val Leu Val Phe Glu Asn Gln Phe Ile Glu 
            180                 185                 190         


Phe Ala Ser Ala Leu Pro Glu Asn Tyr Asn Leu Tyr Gly Leu Gly Glu 
        195                 200                 205             


Arg Ile His Gly Leu Arg Leu Gly Asn Asn Phe Thr Ala Thr Thr Tyr 
    210                 215                 220                 


Ala Ala Asp Ser Ala Asp Pro Ile Asp Arg Asn Ile Tyr Gly Thr His 
225                 230                 235                 240 


Pro Phe Tyr Leu Asp Thr Arg Tyr Tyr Glu Val Asp Ser Glu His Gly 
                245                 250                 255     


Arg Phe Thr Leu Val Thr Asp Asn Glu Thr Asp Phe Ser Lys Glu Tyr 
            260                 265                 270         


Leu Ser Leu Ser His Gly Val Phe Leu Arg Asn Ala His Gly Gln Glu 
        275                 280                 285             


Val Leu Leu Arg Pro Gln Ser Ile Thr Trp Arg Thr Leu Gly Gly Ser 
    290                 295                 300                 


Ile Asp Leu Tyr Phe Tyr Ala Gly Pro Thr Gln Ala Asp Val Thr Arg 
305                 310                 315                 320 


Ser Tyr Gln Thr Ser Thr Val Gly Leu Pro Ala Met Gln Gln Tyr Phe 
                325                 330                 335     


Thr Leu Gly Tyr His Gln Cys Arg Trp Gly Tyr Arg Asn Trp Ser Glu 
            340                 345                 350         


Leu Ala Asp Val Val Ala Asn Phe Glu Lys Phe Glu Ile Pro Leu Glu 
        355                 360                 365             


Asn Ile Trp Ser Asp Ile Asp Tyr Met Asn Glu Tyr Arg Asp Phe Glu 
    370                 375                 380                 


Asn Asp Pro Val Arg Phe Ser Tyr Ser Glu Gly Ala Lys Phe Leu Asp 
385                 390                 395                 400 


Gln Leu His Lys Ser Gly Arg His Tyr Ile Pro Ile Val Asp Ala Ala 
                405                 410                 415     


Ile Tyr Asp Pro Asn Pro Asn Asn Asp Ser Asp Ala Tyr Ala Thr Tyr 
            420                 425                 430         


Asp Arg Gly Ser Lys Asp Asp Ile Trp Leu Lys Asn Pro Asp Gly Ser 
        435                 440                 445             


Val Tyr Ile Gly Ala Val Trp Pro Gly Tyr Thr Val Phe Thr Asp Trp 
    450                 455                 460                 


His His Pro Lys Ala Asn Glu Trp Trp Ala Asn Glu Leu Ala Leu Trp 
465                 470                 475                 480 


His Glu Lys Val Ala Phe Asp Gly Ile Trp Leu Asp Met Asn Glu Val 
                485                 490                 495     


Ser Ser Phe Cys Val Gly Ser Cys Gly Thr Gly Asn Leu Thr Leu Asn 
            500                 505                 510         


Pro Val His Pro Asn Phe Ala Leu Pro Gly Glu Pro Gly Ala Val Ile 
        515                 520                 525             


Tyr Asp Tyr Pro Glu Asp Phe Asn Val Thr Asn Ala Thr Ala Ala Ala 
    530                 535                 540                 


Ser Ala Ser Ala Ala Ser Ser Ser Gln Ala Ala Ala Thr Ala Thr Ala 
545                 550                 555                 560 


Thr Ser Ser Ser Thr Thr Thr Ser Tyr Leu Val Thr Thr Pro Thr Pro 
                565                 570                 575     


Gly Val Arg Asn Val Asn Tyr Pro Pro Tyr Val Ile Asn His Val Gln 
            580                 585                 590         


Glu Gly His Asp Leu Ala Val His Ala Val Ser Pro Asn Ala Thr His 
        595                 600                 605             


Val Asp Gly Val Gln Glu Tyr Asp Val His Asn Leu Trp Gly Tyr Gln 
    610                 615                 620                 


Glu Thr Asn Ala Thr Tyr His Ala Leu Leu Ser Ile Phe Pro Gly Lys 
625                 630                 635                 640 


Arg Pro Phe Ile Ile Ser Arg Ser Thr Phe Ala Gly Ser Gly Arg Trp 
                645                 650                 655     


Ala Gly His Trp Gly Gly Asp Asn Ala Ser Lys Trp Ala Tyr Met Phe 
            660                 665                 670         


Phe Ser Ile Pro Gln Ala Leu Ser Phe Ser Leu Phe Gly Ile Pro Met 
        675                 680                 685             


Phe Gly Val Asp Thr Cys Gly Phe Asn Gly Asn Ser Asp Glu Glu Leu 
    690                 695                 700                 


Cys Asn Arg Trp Met Gln Leu Ser Ala Phe Phe Pro Phe Tyr Arg Asn 
705                 710                 715                 720 


His Asn Val Leu Ser Ala Ile Pro Gln Glu Pro Tyr Val Trp Ala Ser 
                725                 730                 735     


Val Ile Glu Ala Ser Lys Ser Ala Met Arg Ile Arg Tyr Thr Leu Leu 
            740                 745                 750         


Pro Tyr Leu Tyr Thr Leu Phe Tyr Leu Ala His Thr Thr Gly Ser Thr 
        755                 760                 765             


Val Met Arg Ala Leu Ala Trp Glu Phe Pro Asn Asp Pro Ser Leu Ala 
    770                 775                 780                 


Ala Val Asp Arg Gln Phe Leu Leu Gly Pro Ser Leu Met Val Val Pro 
785                 790                 795                 800 


Val Leu Glu Pro Gln Val Asp Thr Val Lys Gly Val Phe Pro Gly Val 
                805                 810                 815     


Ala Gln Gly Gln Val Trp Tyr Asp Trp Tyr Thr Gln Thr Ala Phe Asp 
            820                 825                 830         


Ala Gln Pro Gly Val Asn Thr Thr Ile Ser Ala Pro Leu Gly His Ile 
        835                 840                 845             


Pro Val Phe Val Arg Gly Gly Ser Val Leu Pro Met Gln Gln Pro Ala 
    850                 855                 860                 


Leu Val Thr Arg Asp Val Arg Asn Ser Pro Trp Ser Leu Leu Val Ala 
865                 870                 875                 880 


Leu Gly Ser Asp Gly Thr Ala Ser Gly Gln Leu Tyr Val Asp Asp Gly 
                885                 890                 895     


Glu Ser Ile Thr Pro Pro Ala Ser Leu His Val Asp Phe Val Ala Ala 
            900                 905                 910         


Asn Phe Ser Thr Leu Phe Ala Thr Ala Arg Gly Ala Phe Lys Asp Ser 
        915                 920                 925             


Asn Thr Leu Ala Asn Val Thr Val Leu Gly Val Pro Ala Ala Pro Ser 
    930                 935                 940                 


Ser Ala Val Thr Trp Asn Asn Glu Thr Val Pro Ser Glu Ser Val Ser 
945                 950                 955                 960 


Tyr Asn Ala Thr Ser Lys Val Leu Val Val Asn Gly Leu Gln Ser Leu 
                965                 970                 975     


Thr Arg Asp Gly Ala Trp Ser Ser Asp Trp Val Leu Lys Trp 
            980                 985                 990 


<210>  18
<211>  973
<212>  PRT
<213>  Rasamsonia composticola

<400>  18

Phe Asp Ala Leu Ala Gly Pro Val Ser Ser Thr Thr Ala Ala Ala Pro 
1               5                   10                  15      


Ser Ala Gln Phe Thr Val Pro Ala Ala Ala Asp Val Gly Ala Asn Leu 
            20                  25                  30          


Leu Ala Asn Ile Asp Asp Pro Asn Ala Val Asn Ala Gln Asp Val Cys 
        35                  40                  45              


Pro Gly Tyr Thr Ala Ser Asn Val Gln Asn Thr Glu Ser Gly Phe Val 
    50                  55                  60                  


Ala Thr Leu Thr Leu Ala Gly Lys Pro Cys Asn Val Tyr Gly Thr Asp 
65                  70                  75                  80  


Val Glu Ser Leu Asn Leu Thr Val Glu Tyr Gln Ala Ala Asp Arg Leu 
                85                  90                  95      


Asn Ile Asn Ile Val Pro Thr His Val Asp Ser Ser Asn Gln Ser Trp 
            100                 105                 110         


Tyr Leu Leu Pro Glu Asn Val Val Pro Lys Pro Gly Val Asp Ala Gly 
        115                 120                 125             


Ala Gln Val Pro Glu Ser Asp Leu Val Phe Ser Trp Ser Asn Glu Pro 
    130                 135                 140                 


Ser Phe Asn Phe Lys Val Ile Arg Lys Ala Thr Gly Asp Ile Leu Phe 
145                 150                 155                 160 


Asp Thr Glu Gly Ser Val Leu Val Phe Glu Asn Gln Phe Ile Glu Phe 
                165                 170                 175     


Ala Ser Ala Leu Pro Glu Asn Tyr Asn Leu Tyr Gly Leu Gly Glu Arg 
            180                 185                 190         


Ile His Gly Leu Arg Leu Gly Asn Asn Phe Thr Ala Thr Thr Tyr Ala 
        195                 200                 205             


Ala Asp Ser Ala Asp Pro Ile Asp Arg Asn Ile Tyr Gly Thr His Pro 
    210                 215                 220                 


Phe Tyr Leu Asp Thr Arg Tyr Tyr Glu Val Asp Ser Glu His Gly Arg 
225                 230                 235                 240 


Phe Thr Leu Val Thr Asp Asn Glu Thr Asp Phe Ser Lys Glu Tyr Leu 
                245                 250                 255     


Ser Leu Ser His Gly Val Phe Leu Arg Asn Ala His Gly Gln Glu Val 
            260                 265                 270         


Leu Leu Arg Pro Gln Ser Ile Thr Trp Arg Thr Leu Gly Gly Ser Ile 
        275                 280                 285             


Asp Leu Tyr Phe Tyr Ala Gly Pro Thr Gln Ala Asp Val Thr Arg Ser 
    290                 295                 300                 


Tyr Gln Thr Ser Thr Val Gly Leu Pro Ala Met Gln Gln Tyr Phe Thr 
305                 310                 315                 320 


Leu Gly Tyr His Gln Cys Arg Trp Gly Tyr Arg Asn Trp Ser Glu Leu 
                325                 330                 335     


Ala Asp Val Val Ala Asn Phe Glu Lys Phe Glu Ile Pro Leu Glu Asn 
            340                 345                 350         


Ile Trp Ser Asp Ile Asp Tyr Met Asn Glu Tyr Arg Asp Phe Glu Asn 
        355                 360                 365             


Asp Pro Val Arg Phe Ser Tyr Ser Glu Gly Ala Lys Phe Leu Asp Gln 
    370                 375                 380                 


Leu His Lys Ser Gly Arg His Tyr Ile Pro Ile Val Asp Ala Ala Ile 
385                 390                 395                 400 


Tyr Asp Pro Asn Pro Asn Asn Asp Ser Asp Ala Tyr Ala Thr Tyr Asp 
                405                 410                 415     


Arg Gly Ser Lys Asp Asp Ile Trp Leu Lys Asn Pro Asp Gly Ser Val 
            420                 425                 430         


Tyr Ile Gly Ala Val Trp Pro Gly Tyr Thr Val Phe Thr Asp Trp His 
        435                 440                 445             


His Pro Lys Ala Asn Glu Trp Trp Ala Asn Glu Leu Ala Leu Trp His 
    450                 455                 460                 


Glu Lys Val Ala Phe Asp Gly Ile Trp Leu Asp Met Asn Glu Val Ser 
465                 470                 475                 480 


Ser Phe Cys Val Gly Ser Cys Gly Thr Gly Asn Leu Thr Leu Asn Pro 
                485                 490                 495     


Val His Pro Asn Phe Ala Leu Pro Gly Glu Pro Gly Ala Val Ile Tyr 
            500                 505                 510         


Asp Tyr Pro Glu Asp Phe Asn Val Thr Asn Ala Thr Ala Ala Ala Ser 
        515                 520                 525             


Ala Ser Ala Ala Ser Ser Ser Gln Ala Ala Ala Thr Ala Thr Ala Thr 
    530                 535                 540                 


Ser Ser Ser Thr Thr Thr Ser Tyr Leu Val Thr Thr Pro Thr Pro Gly 
545                 550                 555                 560 


Val Arg Asn Val Asn Tyr Pro Pro Tyr Val Ile Asn His Val Gln Glu 
                565                 570                 575     


Gly His Asp Leu Ala Val His Ala Val Ser Pro Asn Ala Thr His Val 
            580                 585                 590         


Asp Gly Val Gln Glu Tyr Asp Val His Asn Leu Trp Gly Tyr Gln Glu 
        595                 600                 605             


Thr Asn Ala Thr Tyr His Ala Leu Leu Ser Ile Phe Pro Gly Lys Arg 
    610                 615                 620                 


Pro Phe Ile Ile Ser Arg Ser Thr Phe Ala Gly Ser Gly Arg Trp Ala 
625                 630                 635                 640 


Gly His Trp Gly Gly Asp Asn Ala Ser Lys Trp Ala Tyr Met Phe Phe 
                645                 650                 655     


Ser Ile Pro Gln Ala Leu Ser Phe Ser Leu Phe Gly Ile Pro Met Phe 
            660                 665                 670         


Gly Val Asp Thr Cys Gly Phe Asn Gly Asn Ser Asp Glu Glu Leu Cys 
        675                 680                 685             


Asn Arg Trp Met Gln Leu Ser Ala Phe Phe Pro Phe Tyr Arg Asn His 
    690                 695                 700                 


Asn Val Leu Ser Ala Ile Pro Gln Glu Pro Tyr Val Trp Ala Ser Val 
705                 710                 715                 720 


Ile Glu Ala Ser Lys Ser Ala Met Arg Ile Arg Tyr Thr Leu Leu Pro 
                725                 730                 735     


Tyr Leu Tyr Thr Leu Phe Tyr Leu Ala His Thr Thr Gly Ser Thr Val 
            740                 745                 750         


Met Arg Ala Leu Ala Trp Glu Phe Pro Asn Asp Pro Ser Leu Ala Ala 
        755                 760                 765             


Val Asp Arg Gln Phe Leu Leu Gly Pro Ser Leu Met Val Val Pro Val 
    770                 775                 780                 


Leu Glu Pro Gln Val Asp Thr Val Lys Gly Val Phe Pro Gly Val Ala 
785                 790                 795                 800 


Gln Gly Gln Val Trp Tyr Asp Trp Tyr Thr Gln Thr Ala Phe Asp Ala 
                805                 810                 815     


Gln Pro Gly Val Asn Thr Thr Ile Ser Ala Pro Leu Gly His Ile Pro 
            820                 825                 830         


Val Phe Val Arg Gly Gly Ser Val Leu Pro Met Gln Gln Pro Ala Leu 
        835                 840                 845             


Val Thr Arg Asp Val Arg Asn Ser Pro Trp Ser Leu Leu Val Ala Leu 
    850                 855                 860                 


Gly Ser Asp Gly Thr Ala Ser Gly Gln Leu Tyr Val Asp Asp Gly Glu 
865                 870                 875                 880 


Ser Ile Thr Pro Pro Ala Ser Leu His Val Asp Phe Val Ala Ala Asn 
                885                 890                 895     


Phe Ser Thr Leu Phe Ala Thr Ala Arg Gly Ala Phe Lys Asp Ser Asn 
            900                 905                 910         


Thr Leu Ala Asn Val Thr Val Leu Gly Val Pro Ala Ala Pro Ser Ser 
        915                 920                 925             


Ala Val Thr Trp Asn Asn Glu Thr Val Pro Ser Glu Ser Val Ser Tyr 
    930                 935                 940                 


Asn Ala Thr Ser Lys Val Leu Val Val Asn Gly Leu Gln Ser Leu Thr 
945                 950                 955                 960 


Arg Asp Gly Ala Trp Ser Ser Asp Trp Val Leu Lys Trp 
                965                 970             


<210>  19
<211>  1815
<212>  DNA
<213>  Bifidobacterium longum

<400>  19
atgaccgcaa ataatctcaa tgacgactgg tggaagcagg ccgtcgtcta ccagatctac       60

ccgcgcagct tcaaggacgt taacggcgac ggactcggcg acatcgccgg cgtcaccgag      120

aagatggact acctgaagaa cctcggcgtc gacgcaatct ggctctcccc gttctacccc      180

tccgatctgg cggacggcgg ctacgacgta atcgactacc gcaacgtcga cccgcgccta      240

ggcaccatgg aagacttcga cgcgatggcc aaggccgcgc acgaggccgg catcaaggtg      300

atcgtggaca tcgtgcccaa ccacaccgct gacaagcacg tgttcttcca ggaggccctc      360

gccgccgagc ctggctcccc ggcgcgcgac cgctacatct tccgcgacgg ccgcggcgag      420

catggcgaac tgcccccgaa cgactggcaa tccttcttcg gcggcccggc ctgggcgcgc      480

gtggccgacg gccagtggta tctgcacctg ttcgataagg cgcagccgga cgtcaactgg      540

aagaatccgg acatccacga ggagttcaag aagaccctgc gtttctggtc cgaccacggc      600

accgacggct tccgcatcga cgtggcgcac ggcctggcca aggacctcga atccaagccg      660

ttggaagagc tcggccgcga atacagcgtg gtcggcgtgc tgaatcatga cttcagccac      720

ccgctgttcg accgtcgcga ggtgcacgat atctaccgcg aatggcgcaa ggtgttcaac      780

gagtacgacc cgccgcgctt tgccgtggcc gaggcgtggg tggtgcccga gcaccagcac      840

ctgtacgctt cgatggacga gctgggccag tccttcaact tcgacttcgc gcaagccaac      900

tggtatgccg acgagttccg cgaggccatc gccgccggac tcaaggcggc ggccgaaacc      960

ggcggttcca ccaccacgtg ggtcatgaac aatcacgacg tgccgcgcag cccctcccgt     1020

tacggcctgc cgcagatcaa gggcgcaccc taccaccagc tgccgcacga ctggctgctg     1080

cgcaacggca ctacctatcc cgaggatcgc gagcttggca ctcgccgcgc ccgcgccgcc     1140

gctttgatgg agctcggcct gcccggcgcc gcctatatct atcagggcga ggagctgggc     1200

ctgtttgagg tggccgatat tccgtgggat cacttggagg atccgaccgc tttccacact     1260

gctcaggcca cgatggacaa gggccgcgac ggctgccgcg tgccgctgcc gtggaccgcc     1320

gccgatgagc cggccttggc cgatttcagc cgtccgactc cggccgatga cggtaccggc     1380

gagaaccatg tgccgctgtg cgccgccggc cagttcggca cgggcgcttc cttcggcttc     1440

tcgccggcta cgcgcgctga gggcgtgacg ccggccgccg acccgcacct gccgcaaccg     1500

ctgtggttca aggattacgc ggtggacgtg gagcaagccg acccggactc gatgctcgcg     1560

ctgtatcgcg ccgcactggc gattcgccag gagtcgctga ccgccacgcg cgacaccacg     1620

gccgagcagg tggacatggg cgacgatgtg gtggcgtaca cccgcgcggc ggttggcggg     1680

cgggtgttca cctcaatcac caacttcggc aatgctccgg tcgcgctgcc cgatggctcc     1740

gtggtgctgg cgtccggccc gctgaccccc gaagcccagc tccccaccga cacttctgcg     1800

tgggttgttc agtag                                                      1815


<210>  20
<211>  604
<212>  PRT
<213>  Bifidobacterium longum

<400>  20

Met Thr Ala Asn Asn Leu Asn Asp Asp Trp Trp Lys Gln Ala Val Val 
1               5                   10                  15      


Tyr Gln Ile Tyr Pro Arg Ser Phe Lys Asp Val Asn Gly Asp Gly Leu 
            20                  25                  30          


Gly Asp Ile Ala Gly Val Thr Glu Lys Met Asp Tyr Leu Lys Asn Leu 
        35                  40                  45              


Gly Val Asp Ala Ile Trp Leu Ser Pro Phe Tyr Pro Ser Asp Leu Ala 
    50                  55                  60                  


Asp Gly Gly Tyr Asp Val Ile Asp Tyr Arg Asn Val Asp Pro Arg Leu 
65                  70                  75                  80  


Gly Thr Met Glu Asp Phe Asp Ala Met Ala Lys Ala Ala His Glu Ala 
                85                  90                  95      


Gly Ile Lys Val Ile Val Asp Ile Val Pro Asn His Thr Ala Asp Lys 
            100                 105                 110         


His Val Phe Phe Gln Glu Ala Leu Ala Ala Glu Pro Gly Ser Pro Ala 
        115                 120                 125             


Arg Asp Arg Tyr Ile Phe Arg Asp Gly Arg Gly Glu His Gly Glu Leu 
    130                 135                 140                 


Pro Pro Asn Asp Trp Gln Ser Phe Phe Gly Gly Pro Ala Trp Ala Arg 
145                 150                 155                 160 


Val Ala Asp Gly Gln Trp Tyr Leu His Leu Phe Asp Lys Ala Gln Pro 
                165                 170                 175     


Asp Val Asn Trp Lys Asn Pro Asp Ile His Glu Glu Phe Lys Lys Thr 
            180                 185                 190         


Leu Arg Phe Trp Ser Asp His Gly Thr Asp Gly Phe Arg Ile Asp Val 
        195                 200                 205             


Ala His Gly Leu Ala Lys Asp Leu Glu Ser Lys Pro Leu Glu Glu Leu 
    210                 215                 220                 


Gly Arg Glu Tyr Ser Val Val Gly Val Leu Asn His Asp Phe Ser His 
225                 230                 235                 240 


Pro Leu Phe Asp Arg Arg Glu Val His Asp Ile Tyr Arg Glu Trp Arg 
                245                 250                 255     


Lys Val Phe Asn Glu Tyr Asp Pro Pro Arg Phe Ala Val Ala Glu Ala 
            260                 265                 270         


Trp Val Val Pro Glu His Gln His Leu Tyr Ala Ser Met Asp Glu Leu 
        275                 280                 285             


Gly Gln Ser Phe Asn Phe Asp Phe Ala Gln Ala Asn Trp Tyr Ala Asp 
    290                 295                 300                 


Glu Phe Arg Glu Ala Ile Ala Ala Gly Leu Lys Ala Ala Ala Glu Thr 
305                 310                 315                 320 


Gly Gly Ser Thr Thr Thr Trp Val Met Asn Asn His Asp Val Pro Arg 
                325                 330                 335     


Ser Pro Ser Arg Tyr Gly Leu Pro Gln Ile Lys Gly Ala Pro Tyr His 
            340                 345                 350         


Gln Leu Pro His Asp Trp Leu Leu Arg Asn Gly Thr Thr Tyr Pro Glu 
        355                 360                 365             


Asp Arg Glu Leu Gly Thr Arg Arg Ala Arg Ala Ala Ala Leu Met Glu 
    370                 375                 380                 


Leu Gly Leu Pro Gly Ala Ala Tyr Ile Tyr Gln Gly Glu Glu Leu Gly 
385                 390                 395                 400 


Leu Phe Glu Val Ala Asp Ile Pro Trp Asp His Leu Glu Asp Pro Thr 
                405                 410                 415     


Ala Phe His Thr Ala Gln Ala Thr Met Asp Lys Gly Arg Asp Gly Cys 
            420                 425                 430         


Arg Val Pro Leu Pro Trp Thr Ala Ala Asp Glu Pro Ala Leu Ala Asp 
        435                 440                 445             


Phe Ser Arg Pro Thr Pro Ala Asp Asp Gly Thr Gly Glu Asn His Val 
    450                 455                 460                 


Pro Leu Cys Ala Ala Gly Gln Phe Gly Thr Gly Ala Ser Phe Gly Phe 
465                 470                 475                 480 


Ser Pro Ala Thr Arg Ala Glu Gly Val Thr Pro Ala Ala Asp Pro His 
                485                 490                 495     


Leu Pro Gln Pro Leu Trp Phe Lys Asp Tyr Ala Val Asp Val Glu Gln 
            500                 505                 510         


Ala Asp Pro Asp Ser Met Leu Ala Leu Tyr Arg Ala Ala Leu Ala Ile 
        515                 520                 525             


Arg Gln Glu Ser Leu Thr Ala Thr Arg Asp Thr Thr Ala Glu Gln Val 
    530                 535                 540                 


Asp Met Gly Asp Asp Val Val Ala Tyr Thr Arg Ala Ala Val Gly Gly 
545                 550                 555                 560 


Arg Val Phe Thr Ser Ile Thr Asn Phe Gly Asn Ala Pro Val Ala Leu 
                565                 570                 575     


Pro Asp Gly Ser Val Val Leu Ala Ser Gly Pro Leu Thr Pro Glu Ala 
            580                 585                 590         


Gln Leu Pro Thr Asp Thr Ser Ala Trp Val Val Gln 
        595                 600                 


<210>  21
<211>  1812
<212>  DNA
<213>  Artificial sequence

<220>
<223>  BloGlu1_codon-optimized

<400>  21
gtgacagcaa ataatcttaa cgatgattgg tggaaacaag cagtggttta ccaaatctac       60

ccgagatcat ttaaagacgt taatggcgac ggactgggag atattgcggg cgtgacagag      120

aaaatggact atctgaagaa tctgggagtg gatgcgattt ggctgtcacc gttctatccg      180

agcgatctgg ctgacggagg ctacgatgtc attgattata gaaatgtgga tccgagactt      240

ggcacgatgg aggatttcga cgcgatggcg aaggcagccc atgaagcagg cattaaggtt      300

attgtcgata ttgttccgaa tcatacggcg gacaaacatg tgttttttca agaggcactt      360

gccgctgaac ctggaagccc ggctagagat agatacattt tcagagatgg cagaggcgaa      420

cacggcgagc ttcctcctaa cgactggcaa tcattcttcg gaggccctgc atgggcaaga      480

gtggcggacg gccaatggta cctgcatctt tttgataagg cacagccgga tgttaattgg      540

aaaaatcctg atattcacga agagtttaag aaaacactta gattctggtc agatcatggc      600

acggacggat ttagaattga tgtcgcacac ggccttgcga aagatctgga gtcaaaaccg      660

cttgaggagc ttggaagaga atatagcgtg gttggagttc tgaatcatga cttcagccac      720

cctctgtttg acagaagaga ggttcatgac atttatagag aatggagaaa agttttcaat      780

gaatatgatc cgccgagatt tgcggttgct gaggcctggg ttgtgcctga gcatcaacat      840

ctgtacgctt caatggacga gcttggccag tcattcaact ttgattttgc ccaagcaaat      900

tggtatgcag atgaatttag agaggctatt gctgctggcc tgaaagcagc ggctgaaacg      960

ggaggatcaa cgacaacatg ggttatgaat aatcacgatg ttcctagatc accgtcaaga     1020

tatggcctgc ctcagattaa gggcgcaccg tatcaccagc ttccgcacga ttggctgctt     1080

agaaacggca cgacgtaccc ggaagataga gagctgggaa caagaagagc aagagcagca     1140

gctctgatgg aactgggact gcctggcgca gcatacatct atcaaggcga agaacttgga     1200

cttttcgaag ttgcagacat tccgtgggat catctggaag atcctacagc atttcacaca     1260

gcccaggcga caatggataa gggcagagac ggatgtagag tcccgctgcc gtggacagct     1320

gccgatgagc ctgcactggc agacttctca agaccgacac cggccgacga cggaacaggc     1380

gagaaccatg tgccgctttg tgcagccggc cagtttggca caggcgctag ctttggattt     1440

tcaccggcga cgagagcgga aggcgtcaca cctgctgcag atcctcacct gccgcaacct     1500

ctgtggttca aggattatgc tgttgacgtt gagcaagcag acccggactc aatgcttgca     1560

ctgtatagag cggccctggc tattagacaa gaaagcctta cggcaacgag agacacgaca     1620

gcggagcaag ttgatatggg cgatgatgtt gttgcttata caagagccgc agttggcgga     1680

agagtcttta cgtcaattac aaattttggc aatgcaccgg ttgcacttcc ggatggctca     1740

gttgttctgg catcaggccc gcttacacct gaagcacaac tgcctacaga tacgtcagca     1800

tgggtcgttc aa                                                         1812


<210>  22
<211>  604
<212>  PRT
<213>  Bifidobacterium longum

<400>  22

Met Thr Ala Asn Asn Leu Asn Asp Asp Trp Trp Lys Gln Ala Val Val 
1               5                   10                  15      


Tyr Gln Ile Tyr Pro Arg Ser Phe Lys Asp Val Asn Gly Asp Gly Leu 
            20                  25                  30          


Gly Asp Ile Ala Gly Val Thr Glu Lys Met Asp Tyr Leu Lys Asn Leu 
        35                  40                  45              


Gly Val Asp Ala Ile Trp Leu Ser Pro Phe Tyr Pro Ser Asp Leu Ala 
    50                  55                  60                  


Asp Gly Gly Tyr Asp Val Ile Asp Tyr Arg Asn Val Asp Pro Arg Leu 
65                  70                  75                  80  


Gly Thr Met Glu Asp Phe Asp Ala Met Ala Lys Ala Ala His Glu Ala 
                85                  90                  95      


Gly Ile Lys Val Ile Val Asp Ile Val Pro Asn His Thr Ala Asp Lys 
            100                 105                 110         


His Val Phe Phe Gln Glu Ala Leu Ala Ala Glu Pro Gly Ser Pro Ala 
        115                 120                 125             


Arg Asp Arg Tyr Ile Phe Arg Asp Gly Arg Gly Glu His Gly Glu Leu 
    130                 135                 140                 


Pro Pro Asn Asp Trp Gln Ser Phe Phe Gly Gly Pro Ala Trp Ala Arg 
145                 150                 155                 160 


Val Ala Asp Gly Gln Trp Tyr Leu His Leu Phe Asp Lys Ala Gln Pro 
                165                 170                 175     


Asp Val Asn Trp Lys Asn Pro Asp Ile His Glu Glu Phe Lys Lys Thr 
            180                 185                 190         


Leu Arg Phe Trp Ser Asp His Gly Thr Asp Gly Phe Arg Ile Asp Val 
        195                 200                 205             


Ala His Gly Leu Ala Lys Asp Leu Glu Ser Lys Pro Leu Glu Glu Leu 
    210                 215                 220                 


Gly Arg Glu Tyr Ser Val Val Gly Val Leu Asn His Asp Phe Ser His 
225                 230                 235                 240 


Pro Leu Phe Asp Arg Arg Glu Val His Asp Ile Tyr Arg Glu Trp Arg 
                245                 250                 255     


Lys Val Phe Asn Glu Tyr Asp Pro Pro Arg Phe Ala Val Ala Glu Ala 
            260                 265                 270         


Trp Val Val Pro Glu His Gln His Leu Tyr Ala Ser Met Asp Glu Leu 
        275                 280                 285             


Gly Gln Ser Phe Asn Phe Asp Phe Ala Gln Ala Asn Trp Tyr Ala Asp 
    290                 295                 300                 


Glu Phe Arg Glu Ala Ile Ala Ala Gly Leu Lys Ala Ala Ala Glu Thr 
305                 310                 315                 320 


Gly Gly Ser Thr Thr Thr Trp Val Met Asn Asn His Asp Val Pro Arg 
                325                 330                 335     


Ser Pro Ser Arg Tyr Gly Leu Pro Gln Ile Lys Gly Ala Pro Tyr His 
            340                 345                 350         


Gln Leu Pro His Asp Trp Leu Leu Arg Asn Gly Thr Thr Tyr Pro Glu 
        355                 360                 365             


Asp Arg Glu Leu Gly Thr Arg Arg Ala Arg Ala Ala Ala Leu Met Glu 
    370                 375                 380                 


Leu Gly Leu Pro Gly Ala Ala Tyr Ile Tyr Gln Gly Glu Glu Leu Gly 
385                 390                 395                 400 


Leu Phe Glu Val Ala Asp Ile Pro Trp Asp His Leu Glu Asp Pro Thr 
                405                 410                 415     


Ala Phe His Thr Ala Gln Ala Thr Met Asp Lys Gly Arg Asp Gly Cys 
            420                 425                 430         


Arg Val Pro Leu Pro Trp Thr Ala Ala Asp Glu Pro Ala Leu Ala Asp 
        435                 440                 445             


Phe Ser Arg Pro Thr Pro Ala Asp Asp Gly Thr Gly Glu Asn His Val 
    450                 455                 460                 


Pro Leu Cys Ala Ala Gly Gln Phe Gly Thr Gly Ala Ser Phe Gly Phe 
465                 470                 475                 480 


Ser Pro Ala Thr Arg Ala Glu Gly Val Thr Pro Ala Ala Asp Pro His 
                485                 490                 495     


Leu Pro Gln Pro Leu Trp Phe Lys Asp Tyr Ala Val Asp Val Glu Gln 
            500                 505                 510         


Ala Asp Pro Asp Ser Met Leu Ala Leu Tyr Arg Ala Ala Leu Ala Ile 
        515                 520                 525             


Arg Gln Glu Ser Leu Thr Ala Thr Arg Asp Thr Thr Ala Glu Gln Val 
    530                 535                 540                 


Asp Met Gly Asp Asp Val Val Ala Tyr Thr Arg Ala Ala Val Gly Gly 
545                 550                 555                 560 


Arg Val Phe Thr Ser Ile Thr Asn Phe Gly Asn Ala Pro Val Ala Leu 
                565                 570                 575     


Pro Asp Gly Ser Val Val Leu Ala Ser Gly Pro Leu Thr Pro Glu Ala 
            580                 585                 590         


Gln Leu Pro Thr Asp Thr Ser Ala Trp Val Val Gln 
        595                 600                 


<210>  23
<211>  1812
<212>  DNA
<213>  Artificial sequence

<220>
<223>  BloGlu2_codon-optimized

<400>  23
gtgacggcaa acaatctgaa tgatgattgg tggaaacaag cagtggtcta tcagatttat       60

cctagatcat ttaaggatgt taatggcgac ggcctgggag atattgcagg cgtgacggaa      120

aaaatggatt atctgaagaa tctgggcgtt gacgccattt ggctgtcacc gttttacccg      180

agcgacctgg ccgatggcgg ctatgacgtg attgattata gaaatgttga cccgagactg      240

ggcacgatgg acgattttga cgcaatggct gaagccgcac acgaggctgg cattaaagtt      300

attgttgata ttgtcccgaa ccacacagca gacaagcacg tttttttcaa agaagcgctg      360

gcaagcgaac ctggctcacc ggcgagagac agatacattt ttagagacgg aagaggagag      420

catggcgaac tgcctccgaa cgattggcaa tcattctttg gcggacctgc ttgggctaga      480

gtcccggacg gccaatggta ccttcacctg ttcgataaag ctcagccgga tgtgaattgg      540

aaaaatcctg atatccatga agagtttaag aagacgctta gattttggtc agatcatgga      600

acggatggat tcagaattga tgttgcacac ggacttgcaa aggatcttga atcaaaacct      660

cttgaagagc ttggaagaga atactcagtc gttggcgttc ttaatcacga cttttcacac      720

ccgctttttg acagaagaga ggtgcatgat atttacagag aatggagaaa agttttcaat      780

gaatatacac cgccgagatt cgcagtcgcc gaggcgtggg tggtgcctga acatcagcat      840

ctttatgcat caatggatga acttggccag tcatttaact tcgatttcgc tcaagcaaat      900

tggtacgctg atgaatttag aaaagcaatc gctgccggcc tgaaagcagc ggcagaaaca      960

ggaggaagca cgacaacatg ggtcatgaac aatcatgacg tccctagatc accgtcaaga     1020

tacggccttc ctcaggttaa aggcgcaccg tatcaccaac ttccgcacga ctggctgctg     1080

agagatggca cgacgtatcc ggaggataga gaactgggaa caagaagagc aagagcggct     1140

gccctgatgg agctgggact gcctggagca gcctatatct atcaaggcga ggaacttgga     1200

ctgtttgagg ttgctgacat tccttgggat agactggaag atccgacagc gtttcataca     1260

gctcaggcga caatggacaa gggcagagat ggatgcagag ttccgcttcc gtggacggcg     1320

tcagacgaac cggcacttgc agacttctca agacctgccc ctgcagacga cggcacaggc     1380

gagaatcatg ttcctctgtg cgctgctgga caattcggaa caggcgcttc attcggcttt     1440

agccctgccg ttagagcaga cggagttaca cctgcggccg acccgcatct gcctcaaccg     1500

ctttggttta aagattatgc agtggatgtc gagcaagcag atccggactc aatgtatacg     1560

ctgtatcacg ctgcactggc aattagacaa gaatcactga cagctacaag agatacaaca     1620

gctgagcagg tggacatggg agcagatgtg gttgcatata gaagagccgc ggtcgaagga     1680

agaacattta cgtcagttac gaactttggc acagctccgg tttcactgcc ggaaggctca     1740

gtggtgctga cgagcggacc gcttacgcct gacggacagc tgccgacaga cacaagcgca     1800

tgggttatta ag                                                         1812


<210>  24
<211>  604
<212>  PRT
<213>  Bifidobacterium longum

<400>  24

Met Thr Ala Asn Asn Leu Asn Asp Asp Trp Trp Lys Gln Ala Val Val 
1               5                   10                  15      


Tyr Gln Ile Tyr Pro Arg Ser Phe Lys Asp Val Asn Gly Asp Gly Leu 
            20                  25                  30          


Gly Asp Ile Ala Gly Val Thr Glu Lys Met Asp Tyr Leu Lys Asn Leu 
        35                  40                  45              


Gly Val Asp Ala Ile Trp Leu Ser Pro Phe Tyr Pro Ser Asp Leu Ala 
    50                  55                  60                  


Asp Gly Gly Tyr Asp Val Ile Asp Tyr Arg Asn Val Asp Pro Arg Leu 
65                  70                  75                  80  


Gly Thr Met Asp Asp Phe Asp Ala Met Ala Glu Ala Ala His Glu Ala 
                85                  90                  95      


Gly Ile Lys Val Ile Val Asp Ile Val Pro Asn His Thr Ala Asp Lys 
            100                 105                 110         


His Val Phe Phe Lys Glu Ala Leu Ala Ser Glu Pro Gly Ser Pro Ala 
        115                 120                 125             


Arg Asp Arg Tyr Ile Phe Arg Asp Gly Arg Gly Glu His Gly Glu Leu 
    130                 135                 140                 


Pro Pro Asn Asp Trp Gln Ser Phe Phe Gly Gly Pro Ala Trp Ala Arg 
145                 150                 155                 160 


Val Pro Asp Gly Gln Trp Tyr Leu His Leu Phe Asp Lys Ala Gln Pro 
                165                 170                 175     


Asp Val Asn Trp Lys Asn Pro Asp Ile His Glu Glu Phe Lys Lys Thr 
            180                 185                 190         


Leu Arg Phe Trp Ser Asp His Gly Thr Asp Gly Phe Arg Ile Asp Val 
        195                 200                 205             


Ala His Gly Leu Ala Lys Asp Leu Glu Ser Lys Pro Leu Glu Glu Leu 
    210                 215                 220                 


Gly Arg Glu Tyr Ser Val Val Gly Val Leu Asn His Asp Phe Ser His 
225                 230                 235                 240 


Pro Leu Phe Asp Arg Arg Glu Val His Asp Ile Tyr Arg Glu Trp Arg 
                245                 250                 255     


Lys Val Phe Asn Glu Tyr Thr Pro Pro Arg Phe Ala Val Ala Glu Ala 
            260                 265                 270         


Trp Val Val Pro Glu His Gln His Leu Tyr Ala Ser Met Asp Glu Leu 
        275                 280                 285             


Gly Gln Ser Phe Asn Phe Asp Phe Ala Gln Ala Asn Trp Tyr Ala Asp 
    290                 295                 300                 


Glu Phe Arg Lys Ala Ile Ala Ala Gly Leu Lys Ala Ala Ala Glu Thr 
305                 310                 315                 320 


Gly Gly Ser Thr Thr Thr Trp Val Met Asn Asn His Asp Val Pro Arg 
                325                 330                 335     


Ser Pro Ser Arg Tyr Gly Leu Pro Gln Val Lys Gly Ala Pro Tyr His 
            340                 345                 350         


Gln Leu Pro His Asp Trp Leu Leu Arg Asp Gly Thr Thr Tyr Pro Glu 
        355                 360                 365             


Asp Arg Glu Leu Gly Thr Arg Arg Ala Arg Ala Ala Ala Leu Met Glu 
    370                 375                 380                 


Leu Gly Leu Pro Gly Ala Ala Tyr Ile Tyr Gln Gly Glu Glu Leu Gly 
385                 390                 395                 400 


Leu Phe Glu Val Ala Asp Ile Pro Trp Asp Arg Leu Glu Asp Pro Thr 
                405                 410                 415     


Ala Phe His Thr Ala Gln Ala Thr Met Asp Lys Gly Arg Asp Gly Cys 
            420                 425                 430         


Arg Val Pro Leu Pro Trp Thr Ala Ser Asp Glu Pro Ala Leu Ala Asp 
        435                 440                 445             


Phe Ser Arg Pro Ala Pro Ala Asp Asp Gly Thr Gly Glu Asn His Val 
    450                 455                 460                 


Pro Leu Cys Ala Ala Gly Gln Phe Gly Thr Gly Ala Ser Phe Gly Phe 
465                 470                 475                 480 


Ser Pro Ala Val Arg Ala Asp Gly Val Thr Pro Ala Ala Asp Pro His 
                485                 490                 495     


Leu Pro Gln Pro Leu Trp Phe Lys Asp Tyr Ala Val Asp Val Glu Gln 
            500                 505                 510         


Ala Asp Pro Asp Ser Met Tyr Thr Leu Tyr His Ala Ala Leu Ala Ile 
        515                 520                 525             


Arg Gln Glu Ser Leu Thr Ala Thr Arg Asp Thr Thr Ala Glu Gln Val 
    530                 535                 540                 


Asp Met Gly Ala Asp Val Val Ala Tyr Arg Arg Ala Ala Val Glu Gly 
545                 550                 555                 560 


Arg Thr Phe Thr Ser Val Thr Asn Phe Gly Thr Ala Pro Val Ser Leu 
                565                 570                 575     


Pro Glu Gly Ser Val Val Leu Thr Ser Gly Pro Leu Thr Pro Asp Gly 
            580                 585                 590         


Gln Leu Pro Thr Asp Thr Ser Ala Trp Val Ile Lys 
        595                 600                 


<210>  25
<211>  1815
<212>  DNA
<213>  Bifidobacterium longum

<400>  25
atgaccgcca acaacctcaa tgacgactgg tggaagcagg ccgtcgtcta ccagatctac       60

ccgcgcagct tcaaggacgt caacggcgac ggactcggcg acatcgccgg cgtcaccgag      120

aagatggatt acctgaagaa cctcggcgtc gacgcgatct ggctctcccc gttctacccc      180

tcggatctgg cggacggcgg ctacgacgtg atcgactacc gcaacgtcga cccgcgccta      240

ggcaccatgg acgacttcga cgcgatggcc gaggccgcgc acgaggccgg catcaaagtg      300

atcgtggaca tcgtgcccaa ccacaccgcc gacaagcacg tgttcttcaa ggaagccctc      360

gcctccgaac ctggctcccc cgcacgcgat cgctatatct tccgtgacgg ccgcggcgag      420

cacggcgaac tgccgccgaa cgactggcag tccttcttcg gcggcccggc ctgggcgcgc      480

gtgcccgacg gccagtggta cctgcatctg ttcgacaagg cgcagccgga cgtcaactgg      540

aagaatccgg acatccacga ggagttcaaa aagaccctgc gcttctggtc cgaccacggc      600

accgacggct tccgcatcga cgtagcgcac ggcctggcca aagaccttga atccaagccg      660

ctggaggagc tcggccgcga atacagcgtg gtcggcgtgc tgaaccacga cttcagccac      720

ccgctgttcg accgccgcga ggtgcacgac atctaccgcg aatggcgcaa ggtgttcaac      780

gaatacactc cgccgcgctt cgccgtggcc gaggcgtggg tggtgcccga gcaccagcac      840

ctgtacgctt cgatggacga gctgggccag tccttcaact tcgacttcgc gcaggccaac      900

tggtatgccg acgagttccg caaggccatc gccgccgggc tcaaggcggc ggccgaaacc      960

ggcggctcca ccaccacgtg ggtcatgaac aatcatgacg tgccgcgcag cccctcccgc     1020

tatggtctgc cgcaggtcaa gggcgcgccg tatcaccagc tgccacacga ctggctgctg     1080

cgcgacggca ccacctaccc ggagaaccgc gaactcggca cccgccgtgc ccgtgccgcc     1140

gcgctgatgg agctcggcct gcccggtgcc gcatacatct atcagggcga ggaactgggc     1200

ctgtttgagg tggccgatat tccgtgggat cacttggagg atccgaccgc cttccacacc     1260

acccgcaaca cgatggacaa gggccgcgac ggctgccgcg tgccgctgcc gtggaccgcc     1320

gccgatgagc cggccttggc cgatttcagc cgtccggctc cggccgatga cggtaccggc     1380

gaaaaccatg tgccgctgtg cgccgccggc cagttcggca cgggcgcttc cttcggcttc     1440

tcccctgcgg ttcgcgccga tggcgtgacg ccggccgccg acccgcacct gccgcagccg     1500

ctgtggttca aggattacgc ggtggacgtg gagcaagccg acccggactc gatgctcgcg     1560

ctgtatcgcg ccgcactggc gattcgccag gagtcgctga ccgccacgcg cgacaccacg     1620

gccgagcagg tggacatggg cgacgatgtg gtggcgtaca cccgcgcggc ggttggcggg     1680

cgggtgttca cctcaatcac caacttcggc aatgccccgg tcgcgctgcc cgatggctcc     1740

gtggtgctgg cgtccggccc gctgaccccc gaaggccagc tccccaccga cacttctgcg     1800

tgggttatca agtag                                                      1815


<210>  26
<211>  604
<212>  PRT
<213>  Bifidobacterium longum

<400>  26

Met Thr Ala Asn Asn Leu Asn Asp Asp Trp Trp Lys Gln Ala Val Val 
1               5                   10                  15      


Tyr Gln Ile Tyr Pro Arg Ser Phe Lys Asp Val Asn Gly Asp Gly Leu 
            20                  25                  30          


Gly Asp Ile Ala Gly Val Thr Glu Lys Met Asp Tyr Leu Lys Asn Leu 
        35                  40                  45              


Gly Val Asp Ala Ile Trp Leu Ser Pro Phe Tyr Pro Ser Asp Leu Ala 
    50                  55                  60                  


Asp Gly Gly Tyr Asp Val Ile Asp Tyr Arg Asn Val Asp Pro Arg Leu 
65                  70                  75                  80  


Gly Thr Met Asp Asp Phe Asp Ala Met Ala Glu Ala Ala His Glu Ala 
                85                  90                  95      


Gly Ile Lys Val Ile Val Asp Ile Val Pro Asn His Thr Ala Asp Lys 
            100                 105                 110         


His Val Phe Phe Lys Glu Ala Leu Ala Ser Glu Pro Gly Ser Pro Ala 
        115                 120                 125             


Arg Asp Arg Tyr Ile Phe Arg Asp Gly Arg Gly Glu His Gly Glu Leu 
    130                 135                 140                 


Pro Pro Asn Asp Trp Gln Ser Phe Phe Gly Gly Pro Ala Trp Ala Arg 
145                 150                 155                 160 


Val Pro Asp Gly Gln Trp Tyr Leu His Leu Phe Asp Lys Ala Gln Pro 
                165                 170                 175     


Asp Val Asn Trp Lys Asn Pro Asp Ile His Glu Glu Phe Lys Lys Thr 
            180                 185                 190         


Leu Arg Phe Trp Ser Asp His Gly Thr Asp Gly Phe Arg Ile Asp Val 
        195                 200                 205             


Ala His Gly Leu Ala Lys Asp Leu Glu Ser Lys Pro Leu Glu Glu Leu 
    210                 215                 220                 


Gly Arg Glu Tyr Ser Val Val Gly Val Leu Asn His Asp Phe Ser His 
225                 230                 235                 240 


Pro Leu Phe Asp Arg Arg Glu Val His Asp Ile Tyr Arg Glu Trp Arg 
                245                 250                 255     


Lys Val Phe Asn Glu Tyr Thr Pro Pro Arg Phe Ala Val Ala Glu Ala 
            260                 265                 270         


Trp Val Val Pro Glu His Gln His Leu Tyr Ala Ser Met Asp Glu Leu 
        275                 280                 285             


Gly Gln Ser Phe Asn Phe Asp Phe Ala Gln Ala Asn Trp Tyr Ala Asp 
    290                 295                 300                 


Glu Phe Arg Lys Ala Ile Ala Ala Gly Leu Lys Ala Ala Ala Glu Thr 
305                 310                 315                 320 


Gly Gly Ser Thr Thr Thr Trp Val Met Asn Asn His Asp Val Pro Arg 
                325                 330                 335     


Ser Pro Ser Arg Tyr Gly Leu Pro Gln Val Lys Gly Ala Pro Tyr His 
            340                 345                 350         


Gln Leu Pro His Asp Trp Leu Leu Arg Asp Gly Thr Thr Tyr Pro Glu 
        355                 360                 365             


Asn Arg Glu Leu Gly Thr Arg Arg Ala Arg Ala Ala Ala Leu Met Glu 
    370                 375                 380                 


Leu Gly Leu Pro Gly Ala Ala Tyr Ile Tyr Gln Gly Glu Glu Leu Gly 
385                 390                 395                 400 


Leu Phe Glu Val Ala Asp Ile Pro Trp Asp His Leu Glu Asp Pro Thr 
                405                 410                 415     


Ala Phe His Thr Thr Arg Asn Thr Met Asp Lys Gly Arg Asp Gly Cys 
            420                 425                 430         


Arg Val Pro Leu Pro Trp Thr Ala Ala Asp Glu Pro Ala Leu Ala Asp 
        435                 440                 445             


Phe Ser Arg Pro Ala Pro Ala Asp Asp Gly Thr Gly Glu Asn His Val 
    450                 455                 460                 


Pro Leu Cys Ala Ala Gly Gln Phe Gly Thr Gly Ala Ser Phe Gly Phe 
465                 470                 475                 480 


Ser Pro Ala Val Arg Ala Asp Gly Val Thr Pro Ala Ala Asp Pro His 
                485                 490                 495     


Leu Pro Gln Pro Leu Trp Phe Lys Asp Tyr Ala Val Asp Val Glu Gln 
            500                 505                 510         


Ala Asp Pro Asp Ser Met Leu Ala Leu Tyr Arg Ala Ala Leu Ala Ile 
        515                 520                 525             


Arg Gln Glu Ser Leu Thr Ala Thr Arg Asp Thr Thr Ala Glu Gln Val 
    530                 535                 540                 


Asp Met Gly Asp Asp Val Val Ala Tyr Thr Arg Ala Ala Val Gly Gly 
545                 550                 555                 560 


Arg Val Phe Thr Ser Ile Thr Asn Phe Gly Asn Ala Pro Val Ala Leu 
                565                 570                 575     


Pro Asp Gly Ser Val Val Leu Ala Ser Gly Pro Leu Thr Pro Glu Gly 
            580                 585                 590         


Gln Leu Pro Thr Asp Thr Ser Ala Trp Val Ile Lys 
        595                 600                 


<210>  27
<211>  1812
<212>  DNA
<213>  Artificial sequence

<220>
<223>  BloGlu3_codon-optimized

<400>  27
gtgacagcaa acaacctgaa tgacgactgg tggaaacagg ccgtcgtgta tcaaatttac       60

cctagatcat ttaaggacgt taatggcgat ggactgggag atattgcagg cgtcacggag      120

aagatggatt accttaaaaa cctgggcgtt gatgctattt ggctgtcacc gttttacccg      180

tcagacctgg ctgatggcgg ctatgacgtt atcgattata gaaatgtgga tcctagactg      240

ggcacaatgg atgattttga cgcaatggcc gaagccgcgc atgaagcggg aattaaagtt      300

attgttgata tcgttcctaa tcatacagca gataagcatg tttttttcaa agaagcactg      360

gcctcagaac cgggctcacc tgcaagagat agatacattt ttagagacgg aagaggcgaa      420

cacggcgagc tgcctccgaa tgactggcaa tcattttttg gaggacctgc atgggcaaga      480

gtccctgacg gacaatggta tctgcacctt ttcgataaag cacaaccgga tgttaattgg      540

aaaaaccctg acatccatga agaatttaag aaaacactga gattttggtc agatcacggc      600

acagacggat ttagaattga tgtggcacat ggacttgcaa aagatctgga aagcaaaccg      660

ctggaggaac tgggaagaga gtacagcgtt gttggcgttc ttaatcatga cttttcacat      720

ccgctgtttg acagaagaga agtgcatgac atctacagag aatggagaaa ggtgtttaac      780

gaatatacac cgccgagatt tgcagtcgca gaagcatggg tggtgcctga acaccaacat      840

ctgtatgcat caatggacga gctgggccaa tcattcaatt tcgactttgc acaagctaat      900

tggtatgcag atgagttcag aaaagctatc gctgcgggcc tgaaagcagc agctgagacg      960

ggcggatcaa cgacaacatg ggtcatgaat aatcacgatg ttccgagatc accgtcaaga     1020

tatggcctgc cgcaggttaa gggcgcaccg tatcatcagc ttccgcacga ttggcttctg     1080

agagacggca cgacgtaccc ggagaataga gagctgggaa cgagaagagc aagagcagcg     1140

gcgcttatgg aacttggact gcctggagcg gcttacattt atcagggcga ggagcttggc     1200

ctttttgagg tggcagatat tccttgggat catcttgaag atccgacagc atttcacaca     1260

acaagaaata cgatggataa aggcagagat ggctgcagag tgcctctgcc gtggacagct     1320

gccgatgagc ctgcccttgc cgactttagc agaccggcac ctgccgacga cggaacggga     1380

gagaaccacg ttcctctgtg tgcagcgggc cagtttggca cgggagcatc atttggattc     1440

tcaccggccg ttagagccga tggcgttaca ccggctgcgg acccgcatct gcctcagccg     1500

ctgtggttta aagattatgc agttgacgtt gaacaagccg atcctgattc aatgctggca     1560

ctgtatagag ctgcacttgc tattagacaa gaatcactta cggcaacgag agatacaacg     1620

gcggaacagg tcgacatggg cgatgatgtc gtcgcatata cgagagcggc cgtgggagga     1680

agagttttta caagcattac aaattttggc aacgcacctg tcgcactgcc ggatggcagc     1740

gtcgttctgg cttcaggacc tctgacaccg gagggacaac tgcctacaga cacgtcagct     1800

tgggttatta ag                                                         1812


<210>  28
<211>  585
<212>  PRT
<213>  Bifidobacterium pseudolongum

<400>  28

Met Thr Leu Asn Asn Thr His Asp Asp Trp Trp Lys Gln Ala Val Val 
1               5                   10                  15      


Tyr Gln Val Tyr Pro Arg Ser Phe Arg Asp Ala Asn Gly Asp Gly Leu 
            20                  25                  30          


Gly Asp Ile Ala Gly Ile Thr Ser Arg Ile Pro Tyr Leu Arg Gln Leu 
        35                  40                  45              


Gly Val Asp Ala Leu Trp Leu Ser Pro Phe Tyr Pro Ser Glu Leu Ala 
    50                  55                  60                  


Asp Gly Gly Tyr Asp Val Ile Asp Tyr Arg Asn Val Asp Pro Arg Leu 
65                  70                  75                  80  


Gly Thr Leu Asp Asp Phe Asp Ala Met Val Ala Ala Ala His Ser Ala 
                85                  90                  95      


Gly Leu Lys Val Val Val Asp Ile Val Pro Asn His Thr Ser Asn Met 
            100                 105                 110         


His Pro Trp Phe Gln Glu Ala Leu Ala Ser Ala Pro Gly Ser Pro Ala 
        115                 120                 125             


Arg Asp Arg Tyr Ile Phe Arg Asp Gly Glu Gly Ala His Gly Glu Leu 
    130                 135                 140                 


Pro Pro Asn Asn Trp Gln Ser Leu Phe Gly Gly Pro Ala Trp Glu Ala 
145                 150                 155                 160 


Ala Gly Asp Gly Gln Trp Tyr Leu His Leu Phe Thr Lys Glu Gln Pro 
                165                 170                 175     


Asp Leu Asn Trp Lys Asn Pro Asp Val His Glu Asp Phe Arg Thr Thr 
            180                 185                 190         


Leu Arg Phe Trp Ser Asp Arg Gly Val Asp Gly Phe Arg Ile Asp Val 
        195                 200                 205             


Ala His Gly Leu Ala Lys Asp Leu Asp Ser Glu Pro Leu Lys Asp Leu 
    210                 215                 220                 


Glu Arg Phe Pro Val Gly Gly Asn Pro Val Pro Gly His Pro Leu Trp 
225                 230                 235                 240 


Asp Arg Pro Glu Val His Glu Ile Tyr Arg Glu Trp Asn Lys Val Phe 
                245                 250                 255     


Asn Glu Tyr Asp Pro Pro Arg Phe Ala Val Gly Glu Ala Trp Val Pro 
            260                 265                 270         


Ala Glu His Gln His Leu Tyr Ala Ser Lys Asp Glu Leu Gly Gln Val 
        275                 280                 285             


Phe Asn Phe Glu Phe Ala Lys Ala Asn Trp Phe Ala Asp Asp Phe Arg 
    290                 295                 300                 


Leu Ala Ile Glu Glu Gly Leu Ala Ser Ala Asp Glu Ser Lys Ser Thr 
305                 310                 315                 320 


Thr Thr Trp Val Met Ser Asn His Asp Val Pro Arg His Val Ser Arg 
                325                 330                 335     


Tyr Gly Leu Pro Gln Val His Thr Arg Gly Tyr His Glu Leu Pro Asn 
            340                 345                 350         


Asp Trp Leu Leu Arg Asn Gly Thr Thr Tyr Ile Glu Asp Arg Glu Leu 
        355                 360                 365             


Gly Thr Arg Arg Ala Arg Ala Ala Ile Leu Met Glu Leu Gly Leu Pro 
    370                 375                 380                 


Gly Ser Val Tyr Val Tyr Gln Gly Glu Glu Leu Gly Leu Pro Glu Val 
385                 390                 395                 400 


Ala Thr Ile Pro Trp Asp His Leu Glu Asp Pro Val Ala Phe Asn Thr 
                405                 410                 415     


Asp His Ser Asp Ala Ala Lys Gly Arg Asp Gly Cys Arg Val Pro Leu 
            420                 425                 430         


Pro Trp Ser Ala Gln Asp Met Pro Gln Pro Ala Pro Trp Asp Pro Glu 
        435                 440                 445             


Phe Gly Thr Gly Ala Ser Phe Gly Phe Ser Glu His Ala Gly Gly Arg 
    450                 455                 460                 


Ala Ser Ala Asp Pro His Leu Pro Gln Pro Leu Trp Tyr Ala Gly Tyr 
465                 470                 475                 480 


Ala Ala Asp Met Glu Asp Thr Asp Pro Ala Ser Met Leu Asn Leu Tyr 
                485                 490                 495     


Arg Arg Ala Met His Trp Arg Gln Glu His Leu Thr Pro Thr Gly Asp 
            500                 505                 510         


Thr Ser Leu Thr Trp Leu Ser Pro Gln Ser Phe Ala Asp Cys Gly Asp 
        515                 520                 525             


Asp Val Val Ala Tyr Ala Arg Pro Leu Ala Asp Asp Ser Gly Asp Arg 
    530                 535                 540                 


Phe Val Cys Ile Val Asn Phe Gly Ala Ala Ser Ile Glu Leu Pro His 
545                 550                 555                 560 


Gly Asp Val Met Met Arg Ser Ile Pro Phe Asp Gly Tyr Gln Leu Pro 
                565                 570                 575     


Ala Asp Ala Ala Val Trp Met Arg Ile 
            580                 585 


<210>  29
<211>  1755
<212>  DNA
<213>  Artificial sequence

<220>
<223>  BpsGlu1_codon-optimized

<400>  29
gtgacactga ataatacaca cgatgactgg tggaaacaag ccgttgtgta tcaagtttat       60

ccgagatcat ttagagacgc taacggcgat ggactgggag acatcgcagg cattacgagc      120

agaatcccgt atcttagaca acttggcgtg gacgcgcttt ggctttcacc gttttatcct      180

agcgagctgg cagacggcgg atatgatgtt attgattaca gaaatgttga cccgagactt      240

ggcacactgg acgactttga tgctatggtg gcggctgccc atagcgcggg actgaaagtt      300

gttgttgata tcgttccgaa tcatacaagc aacatgcacc cttggttcca agaggcgctg      360

gcgagcgcac cgggatcacc tgcgagagat agatacattt tcagagatgg agaaggcgca      420

cacggcgagc ttccgcctaa caattggcaa agcctgtttg gaggaccggc ctgggaagca      480

gcaggcgacg gacaatggta cctgcacctt tttacaaaag aacagcctga tctgaattgg      540

aaaaatcctg acgttcacga ggatttcaga acgacactta gattctggtc agacagaggc      600

gttgatggct ttagaatcga cgttgcacat ggacttgcga aagacctgga tagcgaaccg      660

ctgaaggatc ttgagagatt cccggtcgga ggaaatccgg ttccgggcca tccgctgtgg      720

gatagacctg aagtgcacga gatttacaga gagtggaata aagtctttaa tgaatacgac      780

ccgcctagat tcgctgttgg cgaagcatgg gtgcctgccg aacatcaaca tctttatgcc      840

tcaaaggatg agctgggaca agtgttcaac ttcgaatttg ctaaggcaaa ttggtttgca      900

gatgacttta gactggcaat tgaggagggc ctggcctcag cggacgagtc aaaatcaacg      960

acaacatggg ttatgtcaaa tcacgacgtg ccgagacacg tgagcagata tggccttccg     1020

caagttcata cgagaggcta tcacgagctg cctaacgatt ggctgctgag aaatggcaca     1080

acatatattg aagatagaga actgggcaca agaagagcaa gagccgcgat cctgatggaa     1140

cttggacttc ctggatcagt ttatgtttat caaggcgagg agcttggcct gcctgaggtg     1200

gcaacaattc cttgggacca cctggaagat ccggtcgcct tcaacacaga tcactcagat     1260

gcagcaaaag gaagagacgg atgtagagtg ccgctgccgt ggtcagctca ggatatgccg     1320

cagcctgcgc cgtgggatcc ggaatttggc acgggcgcat catttggatt ctcagagcat     1380

gccggaggca gagcttcagc agacccgcat ctgccgcaac ctctgtggta tgcaggctat     1440

gctgccgata tggaggatac ggatcctgcg tcaatgctga atctgtatag aagagctatg     1500

cactggagac aggagcatct tacacctaca ggcgatacat cactgacatg gctgtcaccg     1560

caatcattcg cagattgcgg agatgatgtc gtggcatacg caagaccgct ggctgacgat     1620

agcggcgaca gatttgtttg cattgttaac ttcggagcag cgagcatcga actgcctcac     1680

ggagacgtta tgatgagatc aatccctttc gatggatacc agcttcctgc ggacgctgcg     1740

gtgtggatga gaatt                                                      1755


<210>  30
<211>  585
<212>  PRT
<213>  Artificial sequence

<220>
<223>  BpsGlu1 protein_encoded by optimized sequence

<400>  30

Met Thr Leu Asn Asn Thr His Asp Asp Trp Trp Lys Gln Ala Val Val 
1               5                   10                  15      


Tyr Gln Val Tyr Pro Arg Ser Phe Arg Asp Ala Asn Gly Asp Gly Leu 
            20                  25                  30          


Gly Asp Ile Ala Gly Ile Thr Ser Arg Ile Pro Tyr Leu Arg Gln Leu 
        35                  40                  45              


Gly Val Asp Ala Leu Trp Leu Ser Pro Phe Tyr Pro Ser Glu Leu Ala 
    50                  55                  60                  


Asp Gly Gly Tyr Asp Val Ile Asp Tyr Arg Asn Val Asp Pro Arg Leu 
65                  70                  75                  80  


Gly Thr Leu Asp Asp Phe Asp Ala Met Val Ala Ala Ala His Ser Ala 
                85                  90                  95      


Gly Leu Lys Val Val Val Asp Ile Val Pro Asn His Thr Ser Asn Met 
            100                 105                 110         


His Pro Trp Phe Gln Glu Ala Leu Ala Ser Ala Pro Gly Ser Pro Ala 
        115                 120                 125             


Arg Asp Arg Tyr Ile Phe Arg Asp Gly Glu Gly Ala His Gly Glu Leu 
    130                 135                 140                 


Pro Pro Asn Asn Trp Gln Ser Leu Phe Gly Gly Pro Ala Trp Glu Ala 
145                 150                 155                 160 


Ala Gly Asp Gly Gln Trp Tyr Leu His Leu Phe Thr Lys Glu Gln Pro 
                165                 170                 175     


Asp Leu Asn Trp Lys Asn Pro Asp Val His Glu Asp Phe Arg Thr Thr 
            180                 185                 190         


Leu Arg Phe Trp Ser Asp Arg Gly Val Asp Gly Phe Arg Ile Asp Val 
        195                 200                 205             


Ala His Gly Leu Ala Lys Asp Leu Asp Ser Glu Pro Leu Lys Asp Leu 
    210                 215                 220                 


Glu Arg Phe Pro Val Gly Gly Asn Pro Val Pro Gly His Pro Leu Trp 
225                 230                 235                 240 


Asp Arg Pro Glu Val His Glu Ile Tyr Arg Glu Trp Asn Lys Val Phe 
                245                 250                 255     


Asn Glu Tyr Asp Pro Pro Arg Phe Ala Val Gly Glu Ala Trp Val Pro 
            260                 265                 270         


Ala Glu His Gln His Leu Tyr Ala Ser Lys Asp Glu Leu Gly Gln Val 
        275                 280                 285             


Phe Asn Phe Glu Phe Ala Lys Ala Asn Trp Phe Ala Asp Asp Phe Arg 
    290                 295                 300                 


Leu Ala Ile Glu Glu Gly Leu Ala Ser Ala Asp Glu Ser Lys Ser Thr 
305                 310                 315                 320 


Thr Thr Trp Val Met Ser Asn His Asp Val Pro Arg His Val Ser Arg 
                325                 330                 335     


Tyr Gly Leu Pro Gln Val His Thr Arg Gly Tyr His Glu Leu Pro Asn 
            340                 345                 350         


Asp Trp Leu Leu Arg Asn Gly Thr Thr Tyr Ile Glu Asp Arg Glu Leu 
        355                 360                 365             


Gly Thr Arg Arg Ala Arg Ala Ala Ile Leu Met Glu Leu Gly Leu Pro 
    370                 375                 380                 


Gly Ser Val Tyr Val Tyr Gln Gly Glu Glu Leu Gly Leu Pro Glu Val 
385                 390                 395                 400 


Ala Thr Ile Pro Trp Asp His Leu Glu Asp Pro Val Ala Phe Asn Thr 
                405                 410                 415     


Asp His Ser Asp Ala Ala Lys Gly Arg Asp Gly Cys Arg Val Pro Leu 
            420                 425                 430         


Pro Trp Ser Ala Gln Asp Met Pro Gln Pro Ala Pro Trp Asp Pro Glu 
        435                 440                 445             


Phe Gly Thr Gly Ala Ser Phe Gly Phe Ser Glu His Ala Gly Gly Arg 
    450                 455                 460                 


Ala Ser Ala Asp Pro His Leu Pro Gln Pro Leu Trp Tyr Ala Gly Tyr 
465                 470                 475                 480 


Ala Ala Asp Met Glu Asp Thr Asp Pro Ala Ser Met Leu Asn Leu Tyr 
                485                 490                 495     


Arg Arg Ala Met His Trp Arg Gln Glu His Leu Thr Pro Thr Gly Asp 
            500                 505                 510         


Thr Ser Leu Thr Trp Leu Ser Pro Gln Ser Phe Ala Asp Cys Gly Asp 
        515                 520                 525             


Asp Val Val Ala Tyr Ala Arg Pro Leu Ala Asp Asp Ser Gly Asp Arg 
    530                 535                 540                 


Phe Val Cys Ile Val Asn Phe Gly Ala Ala Ser Ile Glu Leu Pro His 
545                 550                 555                 560 


Gly Asp Val Met Met Arg Ser Ile Pro Phe Asp Gly Tyr Gln Leu Pro 
                565                 570                 575     


Ala Asp Ala Ala Val Trp Met Arg Ile 
            580                 585 


<210>  31
<211>  1806
<212>  DNA
<213>  Bifidobacterium thermophilum

<400>  31
atggcagaac gcaagtcccc ccagtccgcg caagaatcca cggcatcgga tcgcgccgca       60

gcggcctggt ggcatcaagc ggtggtctat caggtctatc cgcgttcgtt caaggacacc      120

accggttccg gcctcggcga catcgccggt gttaccagcc gcatcggcta cctcaagcaa      180

ctgggtgttg acgcgatttg gctcagcccc ttctatccga gccaactcgc cgatggcggg      240

tacgatgtcg atgattaccg caacgtcgac ccgaaactcg gtacgatgga cgatttcgac      300

aaactcgcca aaaccgcgca cgaggccggt atcaagattg tcgtcgatat cgttcccaac      360

cattcttcca acctgcaccc ctggttcaag gccgcgcttg cagctggtcc gggctcgccg      420

gaacgtgacc gctacatctt ccgtgacggc cgcggtgagc atggcgaact gccgcccacc      480

gactgggtgt cccatttcgg cggccccgcg tggacgcgcg tgcctgacgg ccagtggtat      540

ctgcacctgt tcaccgtgga gcagcccgac tggaactgga agaacccgga tgtgcaggcg      600

gacttcatca agaccctgcg tttttggctt gatcacggcg ctgacggctt ccgtgtcgat      660

gttgcgcacg gcctgtgcaa ggacctcgac cgcgacaatc tcgaccagtg gagcgtcacc      720

ccgccaagcc tgcccgccga cggcagccat ccgctgtacg accgcgacga cgtgcatcag      780

atttatcgcg agtggcgcaa ggtgttcaac gaatatgatc cgccggcatt cgccgtggcc      840

gaggcgtggg ttaatcccgc gcggcagtat ctgtatgcgt ccgacgatga gctcggtcag      900

gtgttcaact tcgagttcgc gaagaagaac tgggtgcgtg acgacatgca tcaggcgatc      960

gaggaaggtc tcgaggcggc gcgtcgttct ggctctaccg ccacgtgggt gatgagtaat     1020

cacgatgttc cacgtcacgc cagccgttac gcactgccgc aagtgccgag cacgcggcat     1080

catcagttgg cgcatgactg gctgctgcgt gacggcacca gctatcacga ggatcgcgaa     1140

gccggtacgc gccgcgcccg ggccgcgatt ttgatggagc ttgcgttgcc cggttcggcg     1200

tacctgtacc agggcgaaga gcttggtctg ttcgaggtcg ctgatattcc gtggaacaag     1260

ctcgaggatc cgaccgcgcg caatagcgaa cgtgcggcca aggacaaggg gcgcgacggg     1320

tgccgcgtcc ccctgccgtg ggtcgccgcc gacggggtcg aggggtcgtt cggcttctcg     1380

cctcgtgtga aatccgtggg cgctggcgtt tccgccgatc aggccgggca gccgtcggag     1440

cctgcacacc tgccgcaacc cgcatggttc gctgatttcg ccgccgaccg tgagagcgcg     1500

cagccggagt cgatgttgaa cctgtaccgc agggcgttgg cgttgcgcca tgagctgatg     1560

ccggccgaca caacgctgac ttggctggat gaagaccgcc cgtctgatgc gccggatggc     1620

gctgacggtc agcacggcgg cgtgattgct taccgccggt ccaacggctg ggcgagtgtg     1680

accaatttcg gtgcggaacc tgtcgcattg ccggcgggcg aggtgctgct cacctccggc     1740

gagctgtgct ccgacggccg gctgccgcaa gataccaccg tttggctgcg gttgaaccag     1800

gactga                                                                1806


<210>  32
<211>  601
<212>  PRT
<213>  Bifidobacterium thermophilum

<400>  32

Met Ala Glu Arg Lys Ser Pro Gln Ser Ala Gln Glu Ser Thr Ala Ser 
1               5                   10                  15      


Asp Arg Ala Ala Ala Ala Trp Trp His Gln Ala Val Val Tyr Gln Val 
            20                  25                  30          


Tyr Pro Arg Ser Phe Lys Asp Thr Thr Gly Ser Gly Leu Gly Asp Ile 
        35                  40                  45              


Ala Gly Val Thr Ser Arg Ile Gly Tyr Leu Lys Gln Leu Gly Val Asp 
    50                  55                  60                  


Ala Ile Trp Leu Ser Pro Phe Tyr Pro Ser Gln Leu Ala Asp Gly Gly 
65                  70                  75                  80  


Tyr Asp Val Asp Asp Tyr Arg Asn Val Asp Pro Lys Leu Gly Thr Met 
                85                  90                  95      


Asp Asp Phe Asp Lys Leu Ala Lys Thr Ala His Glu Ala Gly Ile Lys 
            100                 105                 110         


Ile Val Val Asp Ile Val Pro Asn His Ser Ser Asn Leu His Pro Trp 
        115                 120                 125             


Phe Lys Ala Ala Leu Ala Ala Gly Pro Gly Ser Pro Glu Arg Asp Arg 
    130                 135                 140                 


Tyr Ile Phe Arg Asp Gly Arg Gly Glu His Gly Glu Leu Pro Pro Thr 
145                 150                 155                 160 


Asp Trp Val Ser His Phe Gly Gly Pro Ala Trp Thr Arg Val Pro Asp 
                165                 170                 175     


Gly Gln Trp Tyr Leu His Leu Phe Thr Val Glu Gln Pro Asp Trp Asn 
            180                 185                 190         


Trp Lys Asn Pro Asp Val Gln Ala Asp Phe Ile Lys Thr Leu Arg Phe 
        195                 200                 205             


Trp Leu Asp His Gly Ala Asp Gly Phe Arg Val Asp Val Ala His Gly 
    210                 215                 220                 


Leu Cys Lys Asp Leu Asp Arg Asp Asn Leu Asp Gln Trp Ser Val Thr 
225                 230                 235                 240 


Pro Pro Ser Leu Pro Ala Asp Gly Ser His Pro Leu Tyr Asp Arg Asp 
                245                 250                 255     


Asp Val His Gln Ile Tyr Arg Glu Trp Arg Lys Val Phe Asn Glu Tyr 
            260                 265                 270         


Asp Pro Pro Ala Phe Ala Val Ala Glu Ala Trp Val Asn Pro Ala Arg 
        275                 280                 285             


Gln Tyr Leu Tyr Ala Ser Asp Asp Glu Leu Gly Gln Val Phe Asn Phe 
    290                 295                 300                 


Glu Phe Ala Lys Lys Asn Trp Val Arg Asp Asp Met His Gln Ala Ile 
305                 310                 315                 320 


Glu Glu Gly Leu Glu Ala Ala Arg Arg Ser Gly Ser Thr Ala Thr Trp 
                325                 330                 335     


Val Met Ser Asn His Asp Val Pro Arg His Ala Ser Arg Tyr Ala Leu 
            340                 345                 350         


Pro Gln Val Pro Ser Thr Arg His His Gln Leu Ala His Asp Trp Leu 
        355                 360                 365             


Leu Arg Asp Gly Thr Ser Tyr His Glu Asp Arg Glu Ala Gly Thr Arg 
    370                 375                 380                 


Arg Ala Arg Ala Ala Ile Leu Met Glu Leu Ala Leu Pro Gly Ser Ala 
385                 390                 395                 400 


Tyr Leu Tyr Gln Gly Glu Glu Leu Gly Leu Phe Glu Val Ala Asp Ile 
                405                 410                 415     


Pro Trp Asn Lys Leu Glu Asp Pro Thr Ala Arg Asn Ser Glu Arg Ala 
            420                 425                 430         


Ala Lys Asp Lys Gly Arg Asp Gly Cys Arg Val Pro Leu Pro Trp Val 
        435                 440                 445             


Ala Ala Asp Gly Val Glu Gly Ser Phe Gly Phe Ser Pro Arg Val Lys 
    450                 455                 460                 


Ser Val Gly Ala Gly Val Ser Ala Asp Gln Ala Gly Gln Pro Ser Glu 
465                 470                 475                 480 


Pro Ala His Leu Pro Gln Pro Ala Trp Phe Ala Asp Phe Ala Ala Asp 
                485                 490                 495     


Arg Glu Ser Ala Gln Pro Glu Ser Met Leu Asn Leu Tyr Arg Arg Ala 
            500                 505                 510         


Leu Ala Leu Arg His Glu Leu Met Pro Ala Asp Thr Thr Leu Thr Trp 
        515                 520                 525             


Leu Asp Glu Asp Arg Pro Ser Asp Ala Pro Asp Gly Ala Asp Gly Gln 
    530                 535                 540                 


His Gly Gly Val Ile Ala Tyr Arg Arg Ser Asn Gly Trp Ala Ser Val 
545                 550                 555                 560 


Thr Asn Phe Gly Ala Glu Pro Val Ala Leu Pro Ala Gly Glu Val Leu 
                565                 570                 575     


Leu Thr Ser Gly Glu Leu Cys Ser Asp Gly Arg Leu Pro Gln Asp Thr 
            580                 585                 590         


Thr Val Trp Leu Arg Leu Asn Gln Asp 
        595                 600     


<210>  33
<211>  1803
<212>  DNA
<213>  Artificial sequence

<220>
<223>  BthGlu1_codon-optimized

<400>  33
gtggctgaaa gaaaatcacc gcaaagcgca caggaaagca cggcctcaga cagagcagcc       60

gcagcctggt ggcatcaggc cgttgtttat caagtttatc ctagatcatt caaggataca      120

acgggctcag gactgggcga tattgcagga gttacaagca gaatcggcta ccttaagcaa      180

cttggagtcg atgctatttg gctgtcaccg ttttacccgt cacaactggc cgatggcggc      240

tacgatgttg atgactacag aaacgtggat cctaaactgg gcacaatgga tgattttgat      300

aagctggcaa aaacagcaca tgaggcggga atcaagattg ttgttgatat cgttccgaat      360

catagctcaa atctgcatcc gtggtttaaa gcagcactgg cagccggacc gggcagcccg      420

gagagagata gatacatttt cagagacggc agaggcgaac atggcgaact gcctcctaca      480

gactgggttt cacattttgg aggaccggct tggacaagag ttcctgatgg ccagtggtac      540

ctgcatcttt ttacggttga acagcctgat tggaattgga aaaaccctga cgtccaggcg      600

gacttcatta aaacacttag attctggctg gaccatggag cggatggctt tagagttgac      660

gttgcacatg gcctttgtaa ggaccttgac agagacaacc ttgatcagtg gtcagttacg      720

ccgccttcac tgcctgctga cggatcacac ccgctttatg atagagacga cgttcatcag      780

atttatagag aatggagaaa agtttttaac gaatacgatc ctcctgcgtt tgcagtggca      840

gaagcgtggg ttaatccggc tagacaatat ctttatgcaa gcgacgacga gctgggacaa      900

gttttcaact ttgaatttgc caaaaagaat tgggtcagag atgatatgca tcaagcgatt      960

gaagaaggcc tggaagctgc tagaagaagc ggcagcacag caacatgggt tatgtcaaac     1020

catgatgtgc cgagacacgc gtcaagatac gcacttcctc aagttccgag cacaagacat     1080

caccaacttg ctcatgactg gcttctgaga gacggaacgt cataccacga ggatagagag     1140

gctggaacaa gaagagccag agccgcaatt ctgatggagc tggccctgcc gggatcagca     1200

tatctgtatc agggcgaaga actgggactg tttgaggttg cagacattcc gtggaataag     1260

ctggaagatc cgacagcaag aaattcagaa agagcggcga aagacaaagg aagagatgga     1320

tgtagagtgc cgctgccttg ggtcgctgcc gacggagttg agggctcatt tggattctca     1380

cctagagtta agagcgtcgg agcgggagtt tcagcagacc aggccggaca accgagcgaa     1440

cctgcacatc tgcctcagcc ggcatggttc gccgatttcg cagccgacag agaatcagca     1500

caaccggagt caatgcttaa cctttacaga agagcgcttg ctctgagaca tgaacttatg     1560

cctgccgata cgacactgac atggcttgac gaagatagac cttcagacgc accggacgga     1620

gcagacggac agcatggagg cgttattgca tatagaagat caaacggctg ggcaagcgtt     1680

acaaatttcg gagctgaacc tgtcgcgctt cctgctggcg aggttcttct tacgagcgga     1740

gaactgtgta gcgatggcag acttccgcag gacacaacag tgtggcttag actgaatcag     1800

gat                                                                   1803


<210>  34
<211>  662
<212>  PRT
<213>  Bifidobacterium breve

<400>  34

Met Tyr Phe His Ile Asn His Leu His Asp Thr Val Val Ile Asn Val 
1               5                   10                  15      


Ile Ser Lys His Gly Phe Thr Val Ala Val Arg Val Leu Leu Asn Pro 
            20                  25                  30          


Ile Thr Thr Asn Pro Gln Gln Ser Gly Ala Thr His His Val Ser His 
        35                  40                  45              


Thr Ile Thr His Ala Gln Lys Gly Ile Gly Met Thr Ala Asn Asn Leu 
    50                  55                  60                  


Asn Asp Asp Trp Trp Lys Gln Ala Val Val Tyr Gln Ile Tyr Pro Arg 
65                  70                  75                  80  


Ser Phe Lys Asp Val Asn Gly Asp Gly Ile Gly Asp Ile Ala Gly Val 
                85                  90                  95      


Thr Glu Lys Met Asp Tyr Leu Lys Asn Leu Gly Val Asp Ala Ile Trp 
            100                 105                 110         


Leu Ser Pro Phe Tyr Pro Ser Asp Leu Ala Asp Gly Gly Tyr Asp Val 
        115                 120                 125             


Ile Asp Tyr Arg Asn Val Asp Pro Arg Leu Gly Thr Met Asp Asp Phe 
    130                 135                 140                 


Asp Ala Met Ala Lys Ala Ala His Glu Ala Gly Ile Lys Val Ile Val 
145                 150                 155                 160 


Asp Ile Val Pro Asn His Thr Ala Asp Lys His Val Phe Phe Lys Glu 
                165                 170                 175     


Ala Leu Ala Ala Glu Pro Gly Ser Pro Ala Arg Asp Arg Tyr Ile Phe 
            180                 185                 190         


Arg Asp Gly Arg Gly Glu His Gly Glu Leu Pro Pro Asn Asp Trp Gln 
        195                 200                 205             


Ser Phe Phe Gly Gly Pro Ala Trp Ala Arg Val Ala Asp Gly Gln Trp 
    210                 215                 220                 


Tyr Leu His Leu Phe Asp Lys Ala Gln Pro Asp Val Asn Trp Lys Asn 
225                 230                 235                 240 


Pro Asp Ile His Glu Glu Phe Lys Lys Thr Leu Arg Phe Trp Ser Asp 
                245                 250                 255     


His Gly Thr Asp Gly Phe Arg Ile Asp Val Ala His Gly Leu Ala Lys 
            260                 265                 270         


Asp Leu Glu Ser Lys Pro Leu Glu Glu Leu Gly Arg Glu Tyr Ser Val 
        275                 280                 285             


Val Gly Val Leu Asn His Asp Phe Ser His Pro Leu Phe Asp Arg Arg 
    290                 295                 300                 


Glu Val His Asp Ile Tyr Arg Glu Trp Arg Lys Val Phe Asn Glu Tyr 
305                 310                 315                 320 


Asp Pro Pro Arg Phe Ala Val Ala Glu Ala Trp Val Val Pro Glu His 
                325                 330                 335     


Gln His Leu Tyr Ala Ser Met Asp Glu Leu Gly Gln Ser Phe Asn Phe 
            340                 345                 350         


Asp Phe Ala Gln Ala Ser Trp Tyr Ala Asp Glu Phe Arg Ala Ala Ile 
        355                 360                 365             


Ala Ala Gly Leu Lys Ala Ala Ala Glu Thr Gly Gly Ser Thr Thr Thr 
    370                 375                 380                 


Trp Val Met Asn Asn His Asp Val Pro Arg Ser Pro Ser Arg Tyr Gly 
385                 390                 395                 400 


Leu Pro Gln Val Lys Gly Ala Pro Tyr His Gln Leu Pro His Asp Trp 
                405                 410                 415     


Leu Leu Arg Asn Gly Thr Thr Tyr Pro Glu Asp Arg Glu Leu Gly Thr 
            420                 425                 430         


Arg Arg Ala Arg Ala Ala Ala Leu Met Glu Leu Gly Leu Pro Gly Ala 
        435                 440                 445             


Ala Tyr Ile Tyr Gln Gly Glu Glu Leu Gly Leu Phe Glu Val Ala Asp 
    450                 455                 460                 


Ile Pro Trp Asp Arg Leu Glu Asp Pro Thr Ala Phe His Thr Ala Gln 
465                 470                 475                 480 


Ala Thr Met Asp Lys Gly Arg Asp Gly Cys Arg Val Pro Ile Pro Trp 
                485                 490                 495     


Thr Ala Ala Asn Glu Pro Thr Leu Ala Asp Phe Ser Arg Pro Ile Pro 
            500                 505                 510         


Ala Asp Asp Gly Thr Gly Glu Asn His Val Pro Leu Cys Ala Ala Gly 
        515                 520                 525             


Gln Phe Gly Thr Gly Ala Ser Phe Gly Phe Ser Pro Ala Thr Arg Ala 
    530                 535                 540                 


Glu Gly Val Thr Pro Ala Ala Asp Pro His Leu Pro Gln Pro Leu Trp 
545                 550                 555                 560 


Phe Lys Asp Tyr Ala Val Asp Val Glu Gln Ala Asp Pro Asp Ser Met 
                565                 570                 575     


Leu Ala Leu Tyr His Ala Ala Leu Ala Ile Arg Gln Glu Ser Leu Thr 
            580                 585                 590         


Ala Thr Arg Asp Thr Thr Ala Glu Gln Val Asp Met Gly Pro Asp Val 
        595                 600                 605             


Val Ala Tyr Thr Arg Ala Ala Val Gly Gly Arg Thr Phe Thr Ser Ile 
    610                 615                 620                 


Thr Asn Phe Gly Thr Glu Pro Val Glu Leu Pro Gly Gly Ser Val Val 
625                 630                 635                 640 


Leu Thr Ser Gly Pro Leu Thr Pro Asp Gly Gln Leu Pro Thr Asp Thr 
                645                 650                 655     


Ser Ala Trp Val Ile Lys 
            660         


<210>  35
<211>  1812
<212>  DNA
<213>  Artificial sequence

<220>
<223>  BbrGlu2_codon-optimized

<400>  35
gtgacagcaa ataaccttaa tgacgactgg tggaaacaag cagtggttta ccaaatctat       60

cctagatcat tcaaggatgt taatggcgat ggaattggcg atattgcagg cgttacggaa      120

aaaatggatt acctgaaaaa tctgggagtt gacgctatct ggcttagccc tttttacccg      180

agcgatctgg ccgacggagg ctatgatgtg attgactata gaaatgttga tccgagactg      240

ggaacgatgg atgatttcga tgcgatggct aaggcggcac atgaagcagg cattaaagtt      300

attgttgata ttgtcccgaa tcatacagct gacaaacatg tctttttcaa agaagcactt      360

gcagcagaac cgggctcacc tgccagagac agatacatct ttagagatgg aagaggagaa      420

cacggcgaac ttccgcctaa tgactggcaa tcattctttg gcggaccggc atgggctaga      480

gtcgcagatg gccaatggta ccttcatctt ttcgacaagg cgcaacctga tgtcaattgg      540

aaaaaccctg acattcacga agaattcaag aaaacgctga gattttggtc agatcatggc      600

acggatggct tcagaatcga tgtggcacac ggacttgcaa aagatctgga aagcaaaccg      660

ctggaggaac ttggcagaga atatagcgtg gttggcgttc tgaaccatga cttttcacat      720

ccgctgttcg atagaagaga agttcatgat atctacagag agtggagaaa agtttttaac      780

gaatatgacc cgccgagatt tgccgttgca gaagcatggg tggtgcctga acaccaacac      840

ctgtatgcat caatggacga gctgggacaa tcattcaact ttgattttgc acaggcatca      900

tggtatgccg atgagtttag agctgccatt gccgcaggac ttaaggccgc agcggaaaca      960

ggaggctcaa cgacaacgtg ggtgatgaat aatcacgacg ttcctagaag cccgtcaaga     1020

tatggcctgc cgcaagttaa aggagcacct taccaccagc ttccgcacga ttggcttctg     1080

agaaatggaa caacatatcc ggaagataga gagcttggca cgagaagagc aagagcagcg     1140

gcactgatgg aactgggcct tcctggcgca gcatacattt atcagggcga agaactggga     1200

ctttttgaag tggcggatat tccgtgggat agacttgagg acccgacagc attccacaca     1260

gcacaagcga caatggataa aggaagagac ggatgcagag tgcctattcc ttggacagct     1320

gcaaatgaac ctacactggc agacttcagc agaccgattc cggcagacga cggaacgggc     1380

gaaaaccatg tcccgctgtg cgctgcagga caattcggca caggagcgtc attcggcttt     1440

agcccggcta caagagccga aggagttaca ccggctgcag atccgcatct gcctcaacct     1500

ctttggttta aagattatgc agttgatgtc gagcaggccg acccggattc aatgctggca     1560

ctgtatcatg cagcactggc gattagacaa gaatcactta cagcaacaag agacacgacg     1620

gcggaacaag tggatatggg ccctgacgtt gttgcatata cgagagcggc cgtgggcggc     1680

agaacattta catcaattac aaattttgga acggagcctg ttgaactgcc gggaggatca     1740

gttgttctga caagcggacc tctgacaccg gacggccaac tgcctacgga cacatcagct     1800

tgggtcatca aa                                                         1812


<210>  36
<211>  604
<212>  PRT
<213>  Artificial sequence

<220>
<223>  BbrGlu2 protein_encoded by optimized sequence

<400>  36

Met Thr Ala Asn Asn Leu Asn Asp Asp Trp Trp Lys Gln Ala Val Val 
1               5                   10                  15      


Tyr Gln Ile Tyr Pro Arg Ser Phe Lys Asp Val Asn Gly Asp Gly Ile 
            20                  25                  30          


Gly Asp Ile Ala Gly Val Thr Glu Lys Met Asp Tyr Leu Lys Asn Leu 
        35                  40                  45              


Gly Val Asp Ala Ile Trp Leu Ser Pro Phe Tyr Pro Ser Asp Leu Ala 
    50                  55                  60                  


Asp Gly Gly Tyr Asp Val Ile Asp Tyr Arg Asn Val Asp Pro Arg Leu 
65                  70                  75                  80  


Gly Thr Met Asp Asp Phe Asp Ala Met Ala Lys Ala Ala His Glu Ala 
                85                  90                  95      


Gly Ile Lys Val Ile Val Asp Ile Val Pro Asn His Thr Ala Asp Lys 
            100                 105                 110         


His Val Phe Phe Lys Glu Ala Leu Ala Ala Glu Pro Gly Ser Pro Ala 
        115                 120                 125             


Arg Asp Arg Tyr Ile Phe Arg Asp Gly Arg Gly Glu His Gly Glu Leu 
    130                 135                 140                 


Pro Pro Asn Asp Trp Gln Ser Phe Phe Gly Gly Pro Ala Trp Ala Arg 
145                 150                 155                 160 


Val Ala Asp Gly Gln Trp Tyr Leu His Leu Phe Asp Lys Ala Gln Pro 
                165                 170                 175     


Asp Val Asn Trp Lys Asn Pro Asp Ile His Glu Glu Phe Lys Lys Thr 
            180                 185                 190         


Leu Arg Phe Trp Ser Asp His Gly Thr Asp Gly Phe Arg Ile Asp Val 
        195                 200                 205             


Ala His Gly Leu Ala Lys Asp Leu Glu Ser Lys Pro Leu Glu Glu Leu 
    210                 215                 220                 


Gly Arg Glu Tyr Ser Val Val Gly Val Leu Asn His Asp Phe Ser His 
225                 230                 235                 240 


Pro Leu Phe Asp Arg Arg Glu Val His Asp Ile Tyr Arg Glu Trp Arg 
                245                 250                 255     


Lys Val Phe Asn Glu Tyr Asp Pro Pro Arg Phe Ala Val Ala Glu Ala 
            260                 265                 270         


Trp Val Val Pro Glu His Gln His Leu Tyr Ala Ser Met Asp Glu Leu 
        275                 280                 285             


Gly Gln Ser Phe Asn Phe Asp Phe Ala Gln Ala Ser Trp Tyr Ala Asp 
    290                 295                 300                 


Glu Phe Arg Ala Ala Ile Ala Ala Gly Leu Lys Ala Ala Ala Glu Thr 
305                 310                 315                 320 


Gly Gly Ser Thr Thr Thr Trp Val Met Asn Asn His Asp Val Pro Arg 
                325                 330                 335     


Ser Pro Ser Arg Tyr Gly Leu Pro Gln Val Lys Gly Ala Pro Tyr His 
            340                 345                 350         


Gln Leu Pro His Asp Trp Leu Leu Arg Asn Gly Thr Thr Tyr Pro Glu 
        355                 360                 365             


Asp Arg Glu Leu Gly Thr Arg Arg Ala Arg Ala Ala Ala Leu Met Glu 
    370                 375                 380                 


Leu Gly Leu Pro Gly Ala Ala Tyr Ile Tyr Gln Gly Glu Glu Leu Gly 
385                 390                 395                 400 


Leu Phe Glu Val Ala Asp Ile Pro Trp Asp Arg Leu Glu Asp Pro Thr 
                405                 410                 415     


Ala Phe His Thr Ala Gln Ala Thr Met Asp Lys Gly Arg Asp Gly Cys 
            420                 425                 430         


Arg Val Pro Ile Pro Trp Thr Ala Ala Asn Glu Pro Thr Leu Ala Asp 
        435                 440                 445             


Phe Ser Arg Pro Ile Pro Ala Asp Asp Gly Thr Gly Glu Asn His Val 
    450                 455                 460                 


Pro Leu Cys Ala Ala Gly Gln Phe Gly Thr Gly Ala Ser Phe Gly Phe 
465                 470                 475                 480 


Ser Pro Ala Thr Arg Ala Glu Gly Val Thr Pro Ala Ala Asp Pro His 
                485                 490                 495     


Leu Pro Gln Pro Leu Trp Phe Lys Asp Tyr Ala Val Asp Val Glu Gln 
            500                 505                 510         


Ala Asp Pro Asp Ser Met Leu Ala Leu Tyr His Ala Ala Leu Ala Ile 
        515                 520                 525             


Arg Gln Glu Ser Leu Thr Ala Thr Arg Asp Thr Thr Ala Glu Gln Val 
    530                 535                 540                 


Asp Met Gly Pro Asp Val Val Ala Tyr Thr Arg Ala Ala Val Gly Gly 
545                 550                 555                 560 


Arg Thr Phe Thr Ser Ile Thr Asn Phe Gly Thr Glu Pro Val Glu Leu 
                565                 570                 575     


Pro Gly Gly Ser Val Val Leu Thr Ser Gly Pro Leu Thr Pro Asp Gly 
            580                 585                 590         


Gln Leu Pro Thr Asp Thr Ser Ala Trp Val Ile Lys 
        595                 600                 


<210>  37
<211>  1821
<212>  DNA
<213>  Bifidobacterium breve

<400>  37
atgactactt tcaaccgcgc aataattcct gacgccattc gcaccaacgg agccacgccc       60

aacccgtggt ggtcgaatgc ggtggtgtac cagatctacc cgcggtcgtt ccaggacacg      120

aacggcgatg gtctcggcga cctgaagggc atcacctccc gcctcgacta tcttgccgat      180

ctcggcgtgg atgtgctctg gctctccccg gtctacaggt ccccgcaaga cgacaacggc      240

tacgacatct ccgactaccg ggacatcgac ccgctgttcg gcacgcttga cgacatggac      300

gagctgctgg ccgaagcgca caagcgcggc ctcaagatcg tgatggacct ggtggtcaac      360

cacacctccg acgagcacgc gtggttcgag gcgtcgaagg acaaggacga cccgcacgcc      420

gactggtact ggtggcgtcc cgcccgcccc ggccacgagc cgggcacgcc cggcgccgag      480

ccgaaccagt ggggctccta cttcggcggc tccgcatggg agtacagccc ggagcgcggc      540

gagtactacc tgcaccagtt ctcgaagaag cagcctgatc tcaactggga gaacccggcc      600

gtgcgccgtg cagtgtacga catgatgaat tggtggctcg atcgcggcat cgacggcttc      660

cgtatggacg tcatcaccct tatctccaag cgtacggatg caaacggcag gctccccggc      720

gagtacggtt ccgagctcca tgacctgccg gtgggggagg agggctactc cagcccgaat      780

ccgttctgtg ccgacggtcc gcgtcaggac gagttcctcg ccgagatgcg ccgcgaggtg      840

ttcgacgggc gtgacggctt cctcaccgtc ggcgaggccc ccgggatcac cgccgaacgc      900

aacgagcaca tcaccaatcc ggccaatggg gagctggata tgctgttcct gttcgaacat      960

gtcgattttg attgtgatgg cgtcaagtgg aagcctctgc cgctcgattt gccgggattc     1020

aagcggatca tggccggata tcagactgct gtggagaacg tgggctgggc aagcttgttc     1080

actggtaacc acgatcagcc acgtgtggtc tctcgttggg gcgatgactc ctcggaggaa     1140

tcccgcgtgc gctcggccaa agcgcttggc ctgatgttgc acatgcatcg cggcaccccg     1200

tacgtatatc agggtgagga gctgggcatg accaatgctc acttcaccag cctcgatcag     1260

taccgcgacc ttgaatctct caatgcctat cgtcagaggg tcgaggaagc caaggtacaa     1320

tcgccggaat cgatgatggc gggtatcgcc gcgcgcggtc gcgacaattc gcgtacccca     1380

atgcaatggg atggttctgc ctatgccggt ttcaccgcac cggatgcagc gacggagccg     1440

tggatttccg tcaacccgaa tcatgctgaa atcaatgcgg ccggcgaatt cgacgatcct     1500

gactcggtgt atgccttcta caagaagctc atcgccttgc gccacaacag ttcgattgtg     1560

gcggctggcg agtggcggct gattgatgcg gatgacgcgc atgtatatgc gttcacccgc     1620

acgcttggca acgagcgatt gctggttgtg gttaacctgt ccggccgaac cgtcgacttg     1680

ccgcgtgaat ccaccgagct gattgccggc ggcgtcactg agccagatat cattctctcc     1740

acgtacgacg cccctcacac tgtggtctcc ctcgccaacc gtgagcttga cccgtgggag     1800

gctgctgccg tccagctgta a                                               1821


<210>  38
<211>  419
<212>  DNA
<213>  Bifidobacterium breve


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (84)..(84)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (115)..(115)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (136)..(136)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (138)..(138)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (149)..(149)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (168)..(168)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (183)..(183)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (208)..(208)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (211)..(211)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (213)..(213)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (239)..(239)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (247)..(247)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (284)..(284)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (294)..(294)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (315)..(315)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (337)..(338)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (341)..(341)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (358)..(358)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (380)..(380)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (385)..(385)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (412)..(412)
<223>  n is a, c, g, or t

<400>  38
mttnradart ngatnwwsna vvyyrsdtng dggdkgtsrd yadgvdvwsv yrsddngyds       60

dyrddgtddm daahkrgkvm dvvnhtsdha waskdkddha dwywwrargh gtganwgsyg      120

gsawysrgyy hskkdnwnav rravydmmnw wdrgdgrmdv tskrtdangr gygshdvggy      180

ssncadgrda mrrvdgrdgt vgagtarnht nangdmhvdd cdgvkwkdgk rmagytavnv      240

gwastgnhdr vvsrwgddss srvrsakagm hmhrgtyvyg gmtnahtsdy rdsnayrrva      300

kvssmmagaa rgrdnsrtmw dgsayagtad aatwsvnnha naagdddsvy aykkarhnss      360

vaagwrdadd ahvyatrtgn rvvvnsgrtv drstaggvtd stydahtvvs anrdwaaav       419


<210>  39
<211>  1818
<212>  DNA
<213>  Artificial sequence

<220>
<223>  BbrGlu5_codon-optimized

<400>  39
gtgacaacat tcaatagagc aattattccg gatgcgatta gaacaaatgg agccacaccg       60

aatccgtggt ggtcaaacgc agtggtctat caaatctatc cgagatcatt tcaagacaca      120

aacggagacg gccttggcga tcttaaggga atcacatcaa gactggatta tctggctgac      180

cttggagttg atgttctgtg gctgagcccg gtttatagat cacctcaaga cgacaatggc      240

tatgacatca gcgactatag agacattgat cctctgtttg gcacactgga tgatatggac      300

gagctgcttg cagaagcaca taaaagagga cttaaaatcg ttatggacct ggttgtgaac      360

catacatcag atgaacacgc atggtttgaa gcatcaaaag ataaagacga tccgcacgct      420

gactggtatt ggtggagacc tgctagaccg ggccatgaac cgggaacacc tggcgcagag      480

ccgaaccaat ggggctcata ttttggcgga tcagcatggg agtatagccc ggaaagaggc      540

gaatactatc ttcatcagtt ctcaaaaaaa caaccggatc tgaattggga aaatccggcg      600

gtcagaagag cggtgtacga tatgatgaac tggtggctgg atagaggaat tgatggattt      660

agaatggatg ttattacact gatttcaaaa agaacagacg ccaatggaag acttccggga      720

gaatatggat cagaactgca cgaccttcct gtgggcgaag agggctattc atcacctaat      780

ccgttttgcg ccgacggccc gagacaagat gaattccttg ccgaaatgag aagagaagtt      840

tttgacggaa gagatggctt tctgacagtc ggcgaagcac ctggaattac agcagaaaga      900

aacgaacaca ttacaaaccc tgcaaacggc gaacttgata tgctgttcct gtttgaacat      960

gtggactttg attgcgatgg cgttaaatgg aaaccgcttc cgctggatct tcctggcttt     1020

aaaagaatta tggcaggcta tcagacagca gttgaaaatg tcggatgggc atcactgttt     1080

acaggcaatc atgaccaacc gagagttgtc agcagatggg gcgatgactc atcagaggag     1140

agcagagtta gaagcgccaa agcactgggc cttatgctgc acatgcacag aggcacaccg     1200

tatgtttatc aaggcgagga acttggaatg acaaatgctc attttacgtc acttgaccag     1260

tacagagatc ttgagtcact taatgcttat agacaaagag ttgaagaagc caaggttcag     1320

tcacctgaaa gcatgatggc cggcattgca gctagaggca gagataattc aagaacgccg     1380

atgcaatggg atggaagcgc atacgcaggc tttacggcac ctgacgcagc tacggaaccg     1440

tggatttcag ttaatccgaa tcatgcagaa attaacgcag caggagaatt tgatgacccg     1500

gattcagtct atgcattcta caaaaaactg attgcactga gacataatag cagcattgtt     1560

gcagcgggcg aatggagact tatcgatgca gacgatgcac acgtttatgc gtttacaaga     1620

acacttggca acgagagact gcttgtcgtg gttaatctga gcggcagaac agttgatctg     1680

ccgagagagt caacagagct tattgctggc ggcgtgacag aaccggacat tattctttca     1740

acatatgacg cccctcatac agtggtttca ctggcaaata gagagctgga cccgtgggaa     1800

gctgcggcag tgcagctg                                                   1818


<210>  40
<211>  1570
<212>  PRT
<213>  Streptococcus sp C150

<400>  40

Met Lys Lys Asn Trp Val Thr Ile Gly Val Thr Ala Leu Ser Met Val 
1               5                   10                  15      


Thr Val Ala Gly Gly Thr Leu Leu Glu Asp Gln Gln Val Gln Ala Asp 
            20                  25                  30          


Glu Gln Asn Ala Ala Asn Gln Ser Gly Asp Ser Ser Gln Asp Leu Leu 
        35                  40                  45              


Arg Glu Ala Ser Ala Thr Thr Asn Asp Thr Ala Thr Thr Val Ala Pro 
    50                  55                  60                  


Thr Ile Ser Ala Asp Ala Asn Thr Ala Ser Val Asn Ile Pro Val Ala 
65                  70                  75                  80  


Asp Ala Thr Asn Thr Thr Thr Ala Ala Thr Asp Arg Ala Ala Ala Pro 
                85                  90                  95      


Thr Thr Thr Ala Ala Thr Val Asp Thr Asn Ser Gly Gln Ala Ala Pro 
            100                 105                 110         


Ser Thr Asn Val Gln Ala Ala Ala Ala Asp Thr Ser Ala Thr Pro Thr 
        115                 120                 125             


Asp Thr Asn Thr Asn Thr Asn Ala Ser Val Thr Ala Thr Asp Arg Ala 
    130                 135                 140                 


Val Ala Thr Asp Thr Ala Asn Thr Glu Ala Arg Thr Pro Ser Arg Arg 
145                 150                 155                 160 


Ala Leu Ala Glu Thr Arg Glu Ala Asn Thr Asn Thr Ser Thr Gly Ile 
                165                 170                 175     


Gln Trp Ile Asn Gly Lys Gln Tyr Tyr Val Asn Ser Asp Gly Ser Val 
            180                 185                 190         


Arg Lys Asn Phe Val Phe Glu Gln Asp Gly Lys Ser Tyr Tyr Phe Asp 
        195                 200                 205             


Ala Glu Thr Gly Ala Leu Ala Thr Lys Ser Gln Asp Glu Phe Ser Thr 
    210                 215                 220                 


Glu Pro Ile Lys Ala Ala Val Asp Phe Ser Ser Gly Asn Gln Leu Tyr 
225                 230                 235                 240 


Lys Asn Asp Asn Lys Ser Leu Asp Gln Leu Asp Thr Phe Ile Thr Ala 
                245                 250                 255     


Asp Ala Trp Tyr Arg Pro Lys Ser Ile Leu Lys Asp Gly Lys Thr Trp 
            260                 265                 270         


Thr Ala Ser Thr Glu Ala Asp Lys Arg Pro Leu Leu Met Val Trp Trp 
        275                 280                 285             


Pro Asp Lys Ser Thr Gln Val Asn Tyr Leu Asn Tyr Met Gln Asn Gln 
    290                 295                 300                 


Gly Leu Gly Ala Gly Ser Phe Ser Thr Asn Ser Ser Gln Glu Ser Leu 
305                 310                 315                 320 


Asn Leu Ala Ala Lys Ala Val Gln Thr Lys Ile Glu Glu Arg Ile Ala 
                325                 330                 335     


Arg Glu Gly Asn Thr Asn Trp Leu Arg Thr Ser Ile Asp Gln Phe Ile 
            340                 345                 350         


Lys Thr Gln Pro Gly Trp Asn Ser Ser Thr Glu Asn Ser Ser Tyr Asp 
        355                 360                 365             


His Leu Gln Gly Gly Gln Leu Leu Phe Asn Asn Ser Lys Gly Asp Thr 
    370                 375                 380                 


Gly Asn Arg Thr Ser Tyr Ala Asn Ser Asp Tyr Arg Leu Leu Asn Arg 
385                 390                 395                 400 


Thr Pro Thr Asn Gln Ser Gly Thr Arg Lys Tyr Phe Lys Asp Asn Ser 
                405                 410                 415     


Ile Gly Gly Leu Glu Phe Leu Leu Ala Asn Asp Ile Asp Asn Ser Asn 
            420                 425                 430         


Pro Ala Val Gln Ala Glu Gln Leu Asn Trp Leu His Phe Met Met Asn 
        435                 440                 445             


Ile Gly Ser Ile Met Ala Asn Asp Pro Thr Ala Asn Phe Asp Gly Leu 
    450                 455                 460                 


Arg Val Asp Ala Leu Asp Asn Val Asp Ala Asp Leu Leu Gln Ile Ala 
465                 470                 475                 480 


Ser Asp Tyr Phe Lys Ala Val Tyr Gly Val Asp Lys Ser Glu Ala Asn 
                485                 490                 495     


Ala Ile Lys His Leu Ser Tyr Leu Glu Ala Trp Ser Ala Asn Asp Pro 
            500                 505                 510         


Tyr Tyr Asn Lys Asp Thr Lys Gly Ala Gln Leu Pro Ile Asp Asn Ala 
        515                 520                 525             


Leu Arg Asn Ala Leu Thr Asn Leu Leu Met Arg Asp Lys Asn Thr Arg 
    530                 535                 540                 


Met Gln Leu Gly Asp Met Thr Ala Phe Met Asn Ser Ser Leu Asn Pro 
545                 550                 555                 560 


Arg Gly Ala Asn Asp Lys Asn Gly Glu Arg Met Ala Asn Tyr Ile Phe 
                565                 570                 575     


Thr Arg Ala His Asp Thr Glu Ala Gln Thr Ile Ile Gln Arg Ile Ile 
            580                 585                 590         


Arg Asp Arg Ile Asn Pro Asn Leu Phe Gly Tyr Asn Phe Thr Arg Asp 
        595                 600                 605             


Glu Ile Lys Lys Ala Phe Glu Ile Tyr Asn Ala Asp Ile Asn Thr Ala 
    610                 615                 620                 


His Lys Thr Tyr Ala Ser Tyr Asn Leu Pro Ser Val Tyr Ala Leu Met 
625                 630                 635                 640 


Leu Thr Asn Lys Asp Ser Val Thr Arg Val Tyr Tyr Gly Asp Leu Tyr 
                645                 650                 655     


Arg Glu Asp Gly His Tyr Met Ala Lys Lys Thr Pro Tyr Phe Asp Ala 
            660                 665                 670         


Ile Asp Thr Leu Leu Arg Ala Arg Ile Lys Tyr Val Ala Gly Gly Gln 
        675                 680                 685             


Asp Met Glu Val Lys Lys Val Gly Asn Asp Gly Leu Leu Thr Ser Val 
    690                 695                 700                 


Arg Tyr Gly Lys Gly Ala Asn Asn Ser Thr Asp Trp Gly Thr Thr Glu 
705                 710                 715                 720 


Thr Arg Thr Gln Gly Met Gly Val Ile Leu Thr Asn Asn Tyr Asp Phe 
                725                 730                 735     


Arg Leu Gly Ser Asn Glu Thr Val Thr Met Asn Met Gly Arg Ala His 
            740                 745                 750         


Arg Asn Gln Leu Tyr Arg Pro Leu Leu Leu Thr Thr Lys Asp Gly Leu 
        755                 760                 765             


Ala Thr Tyr Leu Asn Asp Ser Asp Val Pro Ser Asn Leu Leu Lys Arg 
    770                 775                 780                 


Thr Asp Trp Asn Gly Asn Leu Thr Phe Asn Ala Asn Asp Val Phe Gly 
785                 790                 795                 800 


Val Glu Asn Val Gln Val Ser Gly Tyr Leu Gly Val Trp Val Pro Val 
                805                 810                 815     


Gly Ala Lys Ala Asn Gln Asp Ala Arg Thr Gln Pro Ser Asn Arg Ala 
            820                 825                 830         


Asn Ser Asp Gly Gln Val Tyr Lys Ser Ser Ala Ala Leu Asp Ser Gln 
        835                 840                 845             


Val Met Tyr Glu Ala Phe Ser Asn Phe Gln Ala Phe Ala Asp Asp Gln 
    850                 855                 860                 


Pro Glu Leu Tyr Met Asn Arg Val Leu Ala Lys Asn Thr Asp Leu Leu 
865                 870                 875                 880 


Lys Ala Trp Gly Val Thr Ser Val Gly Leu Pro Pro Gln Tyr Val Ser 
                885                 890                 895     


Ser Lys Asp Gly Thr Phe Leu Asp Ser Thr Ile Asp Asn Gly Tyr Ala 
            900                 905                 910         


Phe Asp Asp Arg Tyr Asp Met Ala Leu Ser Gln Asn Asn Lys Tyr Gly 
        915                 920                 925             


Ser Leu Glu Asp Leu Leu Asn Val Leu Arg Ala Leu His Lys Asp Gly 
    930                 935                 940                 


Ile Gln Ala Ile Ala Asp Trp Val Pro Asp Gln Ile Tyr Asn Leu Pro 
945                 950                 955                 960 


Gly Lys Glu Val Val Asn Ala Thr Arg Val Asn Gly Tyr Gly Tyr His 
                965                 970                 975     


Gln Gln Gly Tyr Gln Ile Val Asp Gln Ala Tyr Val Ala Asn Thr Arg 
            980                 985                 990         


Thr Asp Gly Thr Asp Tyr Gln Gly  Arg Tyr Gly Gly Ala  Phe Leu Asp 
        995                 1000                 1005             


Glu Leu  Lys Ala Lys Tyr Pro  Ser Ile Phe Asn Arg  Val Gln Ile 
    1010                 1015                 1020             


Ser Asn  Gly Lys Gln Leu Pro  Thr Asn Glu Lys Ile  Thr Lys Trp 
    1025                 1030                 1035             


Ser Ala  Lys Tyr Phe Asn Gly  Thr Asn Ile Leu Gly  Arg Gly Ile 
    1040                 1045                 1050             


Asn Tyr  Val Leu Arg Asp Asp  Lys Thr Asn Gln Tyr  Phe Asn Thr 
    1055                 1060                 1065             


Ser Ala  Asn Gly Gln Leu Leu  Pro Thr Pro Leu Arg  Asp Thr Gly 
    1070                 1075                 1080             


Ala Ile  Thr Ser Thr Gln Val  Phe Gln Arg Arg Gly  Gln Asp Val 
    1085                 1090                 1095             


Tyr Phe  Leu Arg Asp Asn Gln  Val Ile Lys Asn Glu  Phe Val Gln 
    1100                 1105                 1110             


Asp Gly  Asn Gly Asn Trp Tyr  Tyr Phe Gly Ala Asp  Gly Lys Met 
    1115                 1120                 1125             


Thr Lys  Gly Ala Gln Asn Ile  Asn Ser Lys Asp Tyr  Tyr Phe Phe 
    1130                 1135                 1140             


Asp Asn  Gly Val Gln Leu Arg  Asn Ala Leu Arg Arg  Ala Ser Asn 
    1145                 1150                 1155             


Gly Tyr  Thr Tyr Tyr Tyr Gly  Leu Asp Gly Ala Met  Ile Lys Asn 
    1160                 1165                 1170             


Ala Phe  Val Asp Phe Asp Asp  Lys His Gln Gln Val  Arg Ala Phe 
    1175                 1180                 1185             


Thr Thr  Gln Gly Thr Met Val  Val Gly Asn Leu His  Trp Ser Gly 
    1190                 1195                 1200             


His His  Phe Tyr Phe Asp Arg  Glu Thr Gly Ile Gln  Ala Lys Asp 
    1205                 1210                 1215             


Arg Ile  Val Arg Thr Asp Asp  Gly Lys Leu His Tyr  Tyr Val Ala 
    1220                 1225                 1230             


Gln Thr  Gly Asp Met Gly Arg  Asn Val Phe Ala Thr  Asp Ser Arg 
    1235                 1240                 1245             


Thr Gly  Lys Arg Tyr Tyr Phe  Asp Ala Asp Gly Asn  Thr Val Thr 
    1250                 1255                 1260             


Gly Ser  Arg Val Ile Asp Gly  Lys Thr Tyr Tyr Phe  Asn Gln Asp 
    1265                 1270                 1275             


Gly Ser  Val Gly Thr Ala Tyr  Ser Asn Arg Ala Asp  Ser Ile Ile 
    1280                 1285                 1290             


Phe Glu  Asn Gly Lys Ala Arg  Tyr Ile Thr Pro Ala  Gly Glu Ile 
    1295                 1300                 1305             


Gly Arg  Ser Ile Phe Val Tyr  Asn Pro Ala Thr Lys  Ala Trp Asn 
    1310                 1315                 1320             


Tyr Phe  Asp Lys Glu Gly Asn  Arg Val Thr Gly Arg  Gln Tyr Ile 
    1325                 1330                 1335             


Asp Gly  Asn Leu Tyr Tyr Phe  Lys Glu Asp Gly Ser  Gln Val Lys 
    1340                 1345                 1350             


Gly Ala  Ile Val Glu Glu Asn  Gly Ile Lys Tyr Tyr  Tyr Glu Pro 
    1355                 1360                 1365             


Gly Ser  Gly Ile Leu Ala Ser  Gly Arg Tyr Leu Gln  Val Gly Asp 
    1370                 1375                 1380             


Asp Gln  Trp Ile Tyr Phe Lys  His Asp Gly Ser Leu  Ala Ile Gly 
    1385                 1390                 1395             


Gln Val  Arg Ala Asp Gly Gly  Tyr Leu Lys Tyr Phe  Asp Lys Asn 
    1400                 1405                 1410             


Gly Ile  Gln Val Lys Gly Gln  Thr Ile Val Glu Asp  Gly His Thr 
    1415                 1420                 1425             


Tyr Tyr  Tyr Asp Ala Asp Ser  Gly Ala Leu Val Thr  Ser Ser Phe 
    1430                 1435                 1440             


Ala Glu  Ile Ala Pro Asn Gln  Trp Ala Tyr Phe Asn  Thr Glu Gly 
    1445                 1450                 1455             


Gln Ala  Leu Lys Gly Lys Trp  Thr Ile Asn Gly Lys  Glu Tyr Tyr 
    1460                 1465                 1470             


Phe Asp  Gln Asn Gly Ile Gln  Tyr Lys Gly Lys Ala  Val Lys Val 
    1475                 1480                 1485             


Gly Ser  Arg Tyr Lys Tyr Tyr  Asp Glu Asn Asp Gly  Gln Pro Val 
    1490                 1495                 1500             


Thr Asn  Arg Phe Ala Gln Ile  Glu Pro Asn Val Trp  Ala Tyr Phe 
    1505                 1510                 1515             


Gly Ala  Asp Gly Tyr Ala Val  Thr Gly Glu Gln Val  Ile Asn Gly 
    1520                 1525                 1530             


Gln His  Leu Tyr Phe Asp Gln  Ser Gly Arg Gln Val  Lys Gly Ala 
    1535                 1540                 1545             


Tyr Val  Thr Val Asn Gly Gln  Arg Arg Tyr Tyr Asp  Ala Asn Thr 
    1550                 1555                 1560             


Gly Glu  Tyr Ile Pro Gly Arg  
    1565                 1570 


<210>  41
<211>  4179
<212>  DNA
<213>  Streptococcus sp C150

<400>  41
atcaatggca aacagtacta tgtaaattcg gacggtagcg tgcgtaagaa tttcgttttt       60

gaacaggatg gtaagagcta ctactttgac gcggaaactg gcgcgctggc cactaaaagc      120

caagatgaat ttagcacgga gccgattaaa gcagcagtgg acttctctag cggcaaccag      180

ctgtacaaaa atgacaacaa atcgctggat cagctggata cgtttatcac cgctgacgca      240

tggtaccgcc ctaagtctat tctgaaggat ggcaaaacct ggaccgcgtc taccgaagct      300

gataagcgtc cgttgctgat ggtgtggtgg ccggacaagt ccacccaagt taactacctg      360

aactacatgc agaaccaggg tttgggtgcg ggtagcttca gcaccaatag cagccaagaa      420

tccctgaatc tggctgcgaa agcagttcag accaagatcg aagaacgcat cgcacgtgag      480

ggtaacacca attggctgcg taccagcatt gaccaattca ttaagacgca gccaggctgg      540

aacagcagca ctgagaatag cagctatgat cacttgcagg gtggtcaact gctgttcaat      600

aacagcaaag gtgatacggg taaccgcacc agctatgcga atagcgacta tcgtctgctg      660

aaccgtaccc caactaatca aagcggcacc cgtaagtact ttaaggataa ttccatcggt      720

ggtctggaat ttctgctggc aaacgacatc gacaacagca accctgccgt tcaggcggag      780

cagctgaact ggctgcactt catgatgaac attggttcta tcatggcgaa tgacccgacg      840

gcgaactttg atggtttgcg tgtggacgcg ttggataacg tggatgcgga cctgttgcag      900

atcgcgagcg attacttcaa ggcagtctac ggtgttgata aatccgaggc gaatgcgatc      960

aagcacctga gctatctgga ggcgtggagc gccaatgacc cgtattacaa caaggatacc     1020

aaaggcgcgc aactgccgat tgacaacgcg ctgcgcaacg cactgaccaa cctgttgatg     1080

cgtgacaaga atacgcgcat gcagctgggt gacatgacgg cgtttatgaa tagctctctg     1140

aacccacgtg gtgcgaatga caaaaacggc gagcgtatgg cgaattacat tttcacccgc     1200

gcacacgata ccgaggcgca gaccatcatt cagcgtatta tccgcgatcg tatcaatccg     1260

aacctgtttg gctacaattt cacccgcgat gaaatcaaaa aggcgtttga gatctacaac     1320

gcggacatta acacggcgca taagacgtac gcgagctaca atctgccgtc cgtctacgca     1380

ctgatgctga cgaataagga cagcgtgacc cgtgtgtatt acggtgacct gtatcgtgag     1440

gacggtcact acatggccaa gaaaacgcct tatttcgatg caatcgatac cctgctgcgt     1500

gcgcgcatca aatacgtggc gggtggtcaa gacatggagg tgaagaaagt tggtaatgac     1560

ggcttgctga cgagcgtccg ctatggcaag ggtgcgaaca atagcaccga ctggggcacg     1620

actgaaaccc gtacccaagg tatgggcgtt atcctgacga acaactatga tttccgcctg     1680

ggcagcaacg aaaccgtcac gatgaacatg ggccgtgcgc atcgcaatca gctgtatcgt     1740

ccgctgctgc tgacgaccaa ggatggtctg gccacgtacc tgaatgatag cgacgtgcct     1800

tcgaatttgc tgaaacgcac ggactggaat ggtaacttga cctttaatgc caacgatgtg     1860

tttggtgtag agaacgtcca ggtcagcggt tacctgggtg tttgggtacc ggttggtgct     1920

aaagctaacc aggatgcgcg tacccaaccg agcaaccgtg cgaacagcga tggtcaggtc     1980

tataagtcgt ctgcggcatt ggacagccag gtcatgtatg aggcgtttag caattttcag     2040

gcatttgcgg acgatcaacc ggaactgtac atgaaccgcg ttctggcgaa gaacaccgat     2100

ctgctgaaag cgtggggcgt tactagcgtt ggcttgccgc cacaatacgt tagcagcaaa     2160

gacggcacct tcctggatag cactattgat aacggctatg cgttcgatga tcgttacgac     2220

atggcgctga gccagaacaa caaatacggt tctctggagg acttgctgaa cgttctgcgc     2280

gctctgcaca aagacggtat tcaggcgatt gcggactggg tcccggatca aatctacaat     2340

ttgccgggta aagaggttgt taatgcgacg cgtgttaacg gttacggtta ccatcagcag     2400

ggctaccaga ttgttgacca ggcgtacgtt gcaaacaccc gtacggatgg taccgattat     2460

cagggtcgtt acggtggtgc ttttctggac gaactgaagg cgaagtaccc gagcattttc     2520

aatcgtgtcc agattagcaa cggtaaacag ctgccaacca atgagaaaat cacgaaatgg     2580

tccgcgaaat acttcaatgg cacgaacatc ctgggccgtg gtattaacta tgtgctgcgc     2640

gacgacaaga ccaatcagta tttcaacacc agcgcaaacg gccaactgct gccgacgcca     2700

ctgcgcgaca ccggtgccat caccagcacg caagttttcc agcgtcgtgg ccaagacgtc     2760

tattttctgc gtgataacca ggttatcaaa aacgagtttg tgcaagatgg taacggtaat     2820

tggtactact tcggtgccga cggtaaaatg acgaagggtg cacaaaacat caatagcaag     2880

gattactatt tcttcgataa tggcgtccag ctgcgtaatg cgctgcgtcg cgcgtccaat     2940

ggttacacct actattatgg cctggacggt gccatgatca agaacgcttt cgtcgatttt     3000

gatgataagc accaacaggt gcgtgcgttt actacgcagg gcacgatggt ggtcggtaat     3060

ttgcactgga gcggtcacca cttctatttt gaccgcgaaa cgggtatcca agccaaagac     3120

cgcattgtgc gtaccgatga tggcaagctg cactattatg tcgcacaaac cggcgatatg     3180

ggccgcaatg tgtttgcgac cgacagccgc acgggcaagc gctattactt tgatgcggac     3240

ggcaacaccg ttacgggctc ccgtgtcatc gacggcaaga cctactactt caaccaggac     3300

ggttcggtcg gtaccgcgta cagcaatcgt gcggatagca ttatctttga gaatggcaag     3360

gctcgctata tcactccggc tggcgagatt ggccgttcca tttttgtcta caacccggcg     3420

accaaagcgt ggaattactt cgacaaggaa ggtaaccgtg tcaccggtcg tcagtatatt     3480

gacggcaatc tgtactactt taaagaggac ggctcccaag tgaaaggtgc gattgttgaa     3540

gagaacggta tcaagtacta ctacgaaccg ggcagcggta tcctggcgag cggtcgttat     3600

ctgcaagtcg gtgacgacca atggatctac ttcaaacacg acggtagcct ggcgatcggt     3660

caggttcgtg cagacggtgg ttacttgaaa tactttgata agaatggcat ccaggtcaag     3720

ggccaaacca ttgtggagga tggtcatacc tattactacg atgccgactc cggtgctctg     3780

gtgacctcta gcttcgcgga gattgctccg aaccagtggg cctacttcaa taccgagggc     3840

caagccctga agggcaaatg gaccatcaat ggtaaagagt actattttga tcagaacggc     3900

attcagtata aaggcaaggc agttaaggtc ggcagccgtt acaaatacta tgacgagaat     3960

gacggtcaac cggtcactaa ccgttttgcc cagattgagc cgaacgtctg ggcgtacttt     4020

ggtgccgatg gctacgcagt tactggcgaa caggtgatta atggccagca cctgtacttc     4080

gatcagtcgg gtcgtcaggt taaaggtgcg tacgtcaccg tgaatggtca acgtcgttac     4140

tacgacgcaa acacgggtga atacattccg ggtcgttaa                            4179


<210>  42
<211>  1392
<212>  PRT
<213>  Streptococcus sp C150

<400>  42

Ile Asn Gly Lys Gln Tyr Tyr Val Asn Ser Asp Gly Ser Val Arg Lys 
1               5                   10                  15      


Asn Phe Val Phe Glu Gln Asp Gly Lys Ser Tyr Tyr Phe Asp Ala Glu 
            20                  25                  30          


Thr Gly Ala Leu Ala Thr Lys Ser Gln Asp Glu Phe Ser Thr Glu Pro 
        35                  40                  45              


Ile Lys Ala Ala Val Asp Phe Ser Ser Gly Asn Gln Leu Tyr Lys Asn 
    50                  55                  60                  


Asp Asn Lys Ser Leu Asp Gln Leu Asp Thr Phe Ile Thr Ala Asp Ala 
65                  70                  75                  80  


Trp Tyr Arg Pro Lys Ser Ile Leu Lys Asp Gly Lys Thr Trp Thr Ala 
                85                  90                  95      


Ser Thr Glu Ala Asp Lys Arg Pro Leu Leu Met Val Trp Trp Pro Asp 
            100                 105                 110         


Lys Ser Thr Gln Val Asn Tyr Leu Asn Tyr Met Gln Asn Gln Gly Leu 
        115                 120                 125             


Gly Ala Gly Ser Phe Ser Thr Asn Ser Ser Gln Glu Ser Leu Asn Leu 
    130                 135                 140                 


Ala Ala Lys Ala Val Gln Thr Lys Ile Glu Glu Arg Ile Ala Arg Glu 
145                 150                 155                 160 


Gly Asn Thr Asn Trp Leu Arg Thr Ser Ile Asp Gln Phe Ile Lys Thr 
                165                 170                 175     


Gln Pro Gly Trp Asn Ser Ser Thr Glu Asn Ser Ser Tyr Asp His Leu 
            180                 185                 190         


Gln Gly Gly Gln Leu Leu Phe Asn Asn Ser Lys Gly Asp Thr Gly Asn 
        195                 200                 205             


Arg Thr Ser Tyr Ala Asn Ser Asp Tyr Arg Leu Leu Asn Arg Thr Pro 
    210                 215                 220                 


Thr Asn Gln Ser Gly Thr Arg Lys Tyr Phe Lys Asp Asn Ser Ile Gly 
225                 230                 235                 240 


Gly Leu Glu Phe Leu Leu Ala Asn Asp Ile Asp Asn Ser Asn Pro Ala 
                245                 250                 255     


Val Gln Ala Glu Gln Leu Asn Trp Leu His Phe Met Met Asn Ile Gly 
            260                 265                 270         


Ser Ile Met Ala Asn Asp Pro Thr Ala Asn Phe Asp Gly Leu Arg Val 
        275                 280                 285             


Asp Ala Leu Asp Asn Val Asp Ala Asp Leu Leu Gln Ile Ala Ser Asp 
    290                 295                 300                 


Tyr Phe Lys Ala Val Tyr Gly Val Asp Lys Ser Glu Ala Asn Ala Ile 
305                 310                 315                 320 


Lys His Leu Ser Tyr Leu Glu Ala Trp Ser Ala Asn Asp Pro Tyr Tyr 
                325                 330                 335     


Asn Lys Asp Thr Lys Gly Ala Gln Leu Pro Ile Asp Asn Ala Leu Arg 
            340                 345                 350         


Asn Ala Leu Thr Asn Leu Leu Met Arg Asp Lys Asn Thr Arg Met Gln 
        355                 360                 365             


Leu Gly Asp Met Thr Ala Phe Met Asn Ser Ser Leu Asn Pro Arg Gly 
    370                 375                 380                 


Ala Asn Asp Lys Asn Gly Glu Arg Met Ala Asn Tyr Ile Phe Thr Arg 
385                 390                 395                 400 


Ala His Asp Thr Glu Ala Gln Thr Ile Ile Gln Arg Ile Ile Arg Asp 
                405                 410                 415     


Arg Ile Asn Pro Asn Leu Phe Gly Tyr Asn Phe Thr Arg Asp Glu Ile 
            420                 425                 430         


Lys Lys Ala Phe Glu Ile Tyr Asn Ala Asp Ile Asn Thr Ala His Lys 
        435                 440                 445             


Thr Tyr Ala Ser Tyr Asn Leu Pro Ser Val Tyr Ala Leu Met Leu Thr 
    450                 455                 460                 


Asn Lys Asp Ser Val Thr Arg Val Tyr Tyr Gly Asp Leu Tyr Arg Glu 
465                 470                 475                 480 


Asp Gly His Tyr Met Ala Lys Lys Thr Pro Tyr Phe Asp Ala Ile Asp 
                485                 490                 495     


Thr Leu Leu Arg Ala Arg Ile Lys Tyr Val Ala Gly Gly Gln Asp Met 
            500                 505                 510         


Glu Val Lys Lys Val Gly Asn Asp Gly Leu Leu Thr Ser Val Arg Tyr 
        515                 520                 525             


Gly Lys Gly Ala Asn Asn Ser Thr Asp Trp Gly Thr Thr Glu Thr Arg 
    530                 535                 540                 


Thr Gln Gly Met Gly Val Ile Leu Thr Asn Asn Tyr Asp Phe Arg Leu 
545                 550                 555                 560 


Gly Ser Asn Glu Thr Val Thr Met Asn Met Gly Arg Ala His Arg Asn 
                565                 570                 575     


Gln Leu Tyr Arg Pro Leu Leu Leu Thr Thr Lys Asp Gly Leu Ala Thr 
            580                 585                 590         


Tyr Leu Asn Asp Ser Asp Val Pro Ser Asn Leu Leu Lys Arg Thr Asp 
        595                 600                 605             


Trp Asn Gly Asn Leu Thr Phe Asn Ala Asn Asp Val Phe Gly Val Glu 
    610                 615                 620                 


Asn Val Gln Val Ser Gly Tyr Leu Gly Val Trp Val Pro Val Gly Ala 
625                 630                 635                 640 


Lys Ala Asn Gln Asp Ala Arg Thr Gln Pro Ser Asn Arg Ala Asn Ser 
                645                 650                 655     


Asp Gly Gln Val Tyr Lys Ser Ser Ala Ala Leu Asp Ser Gln Val Met 
            660                 665                 670         


Tyr Glu Ala Phe Ser Asn Phe Gln Ala Phe Ala Asp Asp Gln Pro Glu 
        675                 680                 685             


Leu Tyr Met Asn Arg Val Leu Ala Lys Asn Thr Asp Leu Leu Lys Ala 
    690                 695                 700                 


Trp Gly Val Thr Ser Val Gly Leu Pro Pro Gln Tyr Val Ser Ser Lys 
705                 710                 715                 720 


Asp Gly Thr Phe Leu Asp Ser Thr Ile Asp Asn Gly Tyr Ala Phe Asp 
                725                 730                 735     


Asp Arg Tyr Asp Met Ala Leu Ser Gln Asn Asn Lys Tyr Gly Ser Leu 
            740                 745                 750         


Glu Asp Leu Leu Asn Val Leu Arg Ala Leu His Lys Asp Gly Ile Gln 
        755                 760                 765             


Ala Ile Ala Asp Trp Val Pro Asp Gln Ile Tyr Asn Leu Pro Gly Lys 
    770                 775                 780                 


Glu Val Val Asn Ala Thr Arg Val Asn Gly Tyr Gly Tyr His Gln Gln 
785                 790                 795                 800 


Gly Tyr Gln Ile Val Asp Gln Ala Tyr Val Ala Asn Thr Arg Thr Asp 
                805                 810                 815     


Gly Thr Asp Tyr Gln Gly Arg Tyr Gly Gly Ala Phe Leu Asp Glu Leu 
            820                 825                 830         


Lys Ala Lys Tyr Pro Ser Ile Phe Asn Arg Val Gln Ile Ser Asn Gly 
        835                 840                 845             


Lys Gln Leu Pro Thr Asn Glu Lys Ile Thr Lys Trp Ser Ala Lys Tyr 
    850                 855                 860                 


Phe Asn Gly Thr Asn Ile Leu Gly Arg Gly Ile Asn Tyr Val Leu Arg 
865                 870                 875                 880 


Asp Asp Lys Thr Asn Gln Tyr Phe Asn Thr Ser Ala Asn Gly Gln Leu 
                885                 890                 895     


Leu Pro Thr Pro Leu Arg Asp Thr Gly Ala Ile Thr Ser Thr Gln Val 
            900                 905                 910         


Phe Gln Arg Arg Gly Gln Asp Val Tyr Phe Leu Arg Asp Asn Gln Val 
        915                 920                 925             


Ile Lys Asn Glu Phe Val Gln Asp Gly Asn Gly Asn Trp Tyr Tyr Phe 
    930                 935                 940                 


Gly Ala Asp Gly Lys Met Thr Lys Gly Ala Gln Asn Ile Asn Ser Lys 
945                 950                 955                 960 


Asp Tyr Tyr Phe Phe Asp Asn Gly Val Gln Leu Arg Asn Ala Leu Arg 
                965                 970                 975     


Arg Ala Ser Asn Gly Tyr Thr Tyr Tyr Tyr Gly Leu Asp Gly Ala Met 
            980                 985                 990         


Ile Lys Asn Ala Phe Val Asp Phe  Asp Asp Lys His Gln  Gln Val Arg 
        995                 1000                 1005             


Ala Phe  Thr Thr Gln Gly Thr  Met Val Val Gly Asn  Leu His Trp 
    1010                 1015                 1020             


Ser Gly  His His Phe Tyr Phe  Asp Arg Glu Thr Gly  Ile Gln Ala 
    1025                 1030                 1035             


Lys Asp  Arg Ile Val Arg Thr  Asp Asp Gly Lys Leu  His Tyr Tyr 
    1040                 1045                 1050             


Val Ala  Gln Thr Gly Asp Met  Gly Arg Asn Val Phe  Ala Thr Asp 
    1055                 1060                 1065             


Ser Arg  Thr Gly Lys Arg Tyr  Tyr Phe Asp Ala Asp  Gly Asn Thr 
    1070                 1075                 1080             


Val Thr  Gly Ser Arg Val Ile  Asp Gly Lys Thr Tyr  Tyr Phe Asn 
    1085                 1090                 1095             


Gln Asp  Gly Ser Val Gly Thr  Ala Tyr Ser Asn Arg  Ala Asp Ser 
    1100                 1105                 1110             


Ile Ile  Phe Glu Asn Gly Lys  Ala Arg Tyr Ile Thr  Pro Ala Gly 
    1115                 1120                 1125             


Glu Ile  Gly Arg Ser Ile Phe  Val Tyr Asn Pro Ala  Thr Lys Ala 
    1130                 1135                 1140             


Trp Asn  Tyr Phe Asp Lys Glu  Gly Asn Arg Val Thr  Gly Arg Gln 
    1145                 1150                 1155             


Tyr Ile  Asp Gly Asn Leu Tyr  Tyr Phe Lys Glu Asp  Gly Ser Gln 
    1160                 1165                 1170             


Val Lys  Gly Ala Ile Val Glu  Glu Asn Gly Ile Lys  Tyr Tyr Tyr 
    1175                 1180                 1185             


Glu Pro  Gly Ser Gly Ile Leu  Ala Ser Gly Arg Tyr  Leu Gln Val 
    1190                 1195                 1200             


Gly Asp  Asp Gln Trp Ile Tyr  Phe Lys His Asp Gly  Ser Leu Ala 
    1205                 1210                 1215             


Ile Gly  Gln Val Arg Ala Asp  Gly Gly Tyr Leu Lys  Tyr Phe Asp 
    1220                 1225                 1230             


Lys Asn  Gly Ile Gln Val Lys  Gly Gln Thr Ile Val  Glu Asp Gly 
    1235                 1240                 1245             


His Thr  Tyr Tyr Tyr Asp Ala  Asp Ser Gly Ala Leu  Val Thr Ser 
    1250                 1255                 1260             


Ser Phe  Ala Glu Ile Ala Pro  Asn Gln Trp Ala Tyr  Phe Asn Thr 
    1265                 1270                 1275             


Glu Gly  Gln Ala Leu Lys Gly  Lys Trp Thr Ile Asn  Gly Lys Glu 
    1280                 1285                 1290             


Tyr Tyr  Phe Asp Gln Asn Gly  Ile Gln Tyr Lys Gly  Lys Ala Val 
    1295                 1300                 1305             


Lys Val  Gly Ser Arg Tyr Lys  Tyr Tyr Asp Glu Asn  Asp Gly Gln 
    1310                 1315                 1320             


Pro Val  Thr Asn Arg Phe Ala  Gln Ile Glu Pro Asn  Val Trp Ala 
    1325                 1330                 1335             


Tyr Phe  Gly Ala Asp Gly Tyr  Ala Val Thr Gly Glu  Gln Val Ile 
    1340                 1345                 1350             


Asn Gly  Gln His Leu Tyr Phe  Asp Gln Ser Gly Arg  Gln Val Lys 
    1355                 1360                 1365             


Gly Ala  Tyr Val Thr Val Asn  Gly Gln Arg Arg Tyr  Tyr Asp Ala 
    1370                 1375                 1380             


Asn Thr  Gly Glu Tyr Ile Pro  Gly Arg 
    1385                 1390         


<210>  43
<211>  1455
<212>  PRT
<213>  Streptococcus mutans

<400>  43

Met Glu Lys Lys Val Arg Phe Lys Leu Arg Lys Val Lys Lys Arg Trp 
1               5                   10                  15      


Val Thr Val Ser Val Ala Ser Ala Val Val Thr Leu Thr Ser Leu Ser 
            20                  25                  30          


Gly Ser Leu Val Lys Ala Asp Ser Thr Asp Asp Arg Gln Gln Ala Val 
        35                  40                  45              


Thr Glu Ser Gln Ala Ser Leu Val Thr Thr Ser Glu Ala Ala Lys Glu 
    50                  55                  60                  


Thr Leu Thr Ala Thr Asp Thr Ser Thr Ala Thr Ser Ala Thr Ser Gln 
65                  70                  75                  80  


Leu Thr Ala Thr Val Thr Asp Asn Val Ser Thr Thr Asn Gln Ser Thr 
                85                  90                  95      


Asn Thr Thr Ala Asn Thr Ala Asn Phe Asp Val Lys Pro Thr Thr Thr 
            100                 105                 110         


Ser Glu Gln Ser Lys Thr Asp Asn Ser Asp Lys Ile Ile Ala Thr Ser 
        115                 120                 125             


Lys Ala Val Asn Arg Leu Thr Ala Thr Gly Lys Phe Val Pro Ala Asn 
    130                 135                 140                 


Asn Asn Thr Ala His Pro Lys Thr Val Thr Asp Lys Ile Val Pro Ile 
145                 150                 155                 160 


Lys Pro Lys Ile Gly Lys Leu Lys Gln Pro Ser Ser Leu Ser Gln Asp 
                165                 170                 175     


Asp Ile Ala Ala Leu Gly Asn Val Lys Asn Ile Arg Lys Val Asn Gly 
            180                 185                 190         


Lys Tyr Tyr Tyr Tyr Lys Glu Asp Gly Thr Leu Gln Lys Asn Tyr Ala 
        195                 200                 205             


Leu Asn Ile Asn Gly Lys Thr Phe Phe Phe Asp Glu Thr Gly Ala Leu 
    210                 215                 220                 


Ser Asn Asn Thr Leu Pro Ser Lys Lys Gly Asn Ile Thr Asn Asn Asp 
225                 230                 235                 240 


Asn Thr Asn Ser Phe Ala Gln Tyr Asn Gln Val Tyr Ser Thr Asp Ala 
                245                 250                 255     


Ala Asn Phe Glu His Val Asp His Tyr Leu Thr Ala Glu Ser Trp Tyr 
            260                 265                 270         


Arg Pro Lys Tyr Ile Leu Lys Asp Gly Lys Thr Trp Thr Gln Ser Thr 
        275                 280                 285             


Glu Lys Asp Phe Arg Pro Leu Leu Met Thr Trp Trp Pro Asp Gln Glu 
    290                 295                 300                 


Thr Gln Arg Gln Tyr Val Asn Tyr Met Asn Ala Gln Leu Gly Ile His 
305                 310                 315                 320 


Gln Thr Tyr Asn Thr Ala Thr Ser Pro Leu Gln Leu Asn Leu Ala Ala 
                325                 330                 335     


Gln Thr Ile Gln Thr Lys Ile Glu Glu Lys Ile Thr Ala Glu Lys Asn 
            340                 345                 350         


Thr Asn Trp Leu Arg Gln Thr Ile Ser Ala Phe Val Lys Thr Gln Ser 
        355                 360                 365             


Ala Trp Asn Ser Asp Ser Glu Lys Pro Phe Asp Asp His Leu Gln Lys 
    370                 375                 380                 


Gly Ala Leu Leu Tyr Ser Asn Asn Ser Lys Leu Thr Ser Gln Ala Asn 
385                 390                 395                 400 


Ser Asn Tyr Arg Ile Leu Asn Arg Thr Pro Thr Asn Gln Thr Gly Lys 
                405                 410                 415     


Lys Asp Pro Arg Tyr Thr Ala Asp Arg Thr Ile Gly Gly Tyr Glu Phe 
            420                 425                 430         


Leu Leu Ala Asn Asp Val Asp Asn Ser Asn Pro Val Val Gln Ala Glu 
        435                 440                 445             


Gln Leu Asn Trp Leu His Phe Leu Met Asn Phe Gly Asn Ile Tyr Ala 
    450                 455                 460                 


Asn Asp Pro Asp Ala Asn Phe Asp Ser Ile Arg Val Asp Ala Val Asp 
465                 470                 475                 480 


Asn Val Asp Ala Asp Leu Leu Gln Ile Ala Gly Asp Tyr Leu Lys Ala 
                485                 490                 495     


Ala Lys Gly Ile His Lys Asn Asp Lys Ala Ala Asn Asp His Leu Ser 
            500                 505                 510         


Ile Leu Glu Ala Trp Ser Tyr Asn Asp Thr Pro Tyr Leu His Asp Asp 
        515                 520                 525             


Gly Asp Asn Met Ile Asn Met Asp Asn Arg Leu Arg Leu Ser Leu Leu 
    530                 535                 540                 


Tyr Ser Leu Ala Lys Pro Leu Asn Gln Arg Ser Gly Met Asn Pro Leu 
545                 550                 555                 560 


Ile Thr Asn Ser Leu Val Asn Arg Thr Asp Asp Asn Ala Glu Thr Ala 
                565                 570                 575     


Ala Val Pro Ser Tyr Ser Phe Ile Arg Ala His Asp Ser Glu Val Gln 
            580                 585                 590         


Asp Leu Ile Arg Asn Ile Ile Arg Ala Glu Ile Asn Pro Asn Val Val 
        595                 600                 605             


Gly Tyr Ser Phe Thr Met Glu Glu Ile Lys Lys Ala Phe Glu Ile Tyr 
    610                 615                 620                 


Asn Lys Asp Leu Leu Ala Thr Glu Lys Lys Tyr Thr His Tyr Asn Thr 
625                 630                 635                 640 


Ala Leu Ser Tyr Ala Leu Leu Leu Thr Asn Lys Ser Ser Val Pro Arg 
                645                 650                 655     


Val Tyr Tyr Gly Asp Met Phe Thr Asp Asp Gly Gln Tyr Met Ala His 
            660                 665                 670         


Lys Thr Ile Asn Tyr Glu Ala Ile Glu Thr Leu Leu Lys Ala Arg Ile 
        675                 680                 685             


Lys Tyr Val Ser Gly Gly Gln Ala Met Arg Asn Gln Gln Val Gly Asn 
    690                 695                 700                 


Ser Glu Ile Ile Thr Ser Val Arg Tyr Gly Lys Gly Ala Leu Lys Ala 
705                 710                 715                 720 


Thr Asp Thr Gly Asp Arg Thr Thr Arg Thr Ser Gly Val Ala Val Ile 
                725                 730                 735     


Glu Gly Asn Asn Pro Ser Leu Arg Leu Lys Ala Ser Asp Arg Val Val 
            740                 745                 750         


Val Asn Met Gly Ala Ala His Lys Asn Gln Ala Tyr Arg Pro Leu Leu 
        755                 760                 765             


Leu Thr Thr Asp Asn Gly Ile Lys Ala Tyr His Ser Asp Gln Glu Ala 
    770                 775                 780                 


Ala Gly Leu Val Arg Tyr Thr Asn Asp Arg Gly Glu Leu Ile Phe Thr 
785                 790                 795                 800 


Ala Ala Asp Ile Lys Gly Tyr Ala Asn Pro Gln Val Ser Gly Tyr Leu 
                805                 810                 815     


Gly Val Trp Val Pro Val Gly Ala Ala Ala Asp Gln Asp Val Arg Val 
            820                 825                 830         


Ala Ala Ser Thr Ala Pro Ser Thr Asp Gly Lys Ser Val His Gln Asn 
        835                 840                 845             


Ala Ala Leu Asp Ser Arg Val Met Phe Glu Gly Phe Ser Asn Phe Gln 
    850                 855                 860                 


Ala Phe Ala Thr Lys Lys Glu Glu Tyr Thr Asn Val Val Ile Ala Lys 
865                 870                 875                 880 


Asn Val Asp Lys Phe Ala Glu Trp Gly Val Thr Asp Phe Glu Met Ala 
                885                 890                 895     


Pro Gln Tyr Val Ser Ser Thr Asp Gly Ser Phe Leu Asp Ser Val Ile 
            900                 905                 910         


Gln Asn Gly Tyr Ala Phe Thr Asp Arg Tyr Asp Leu Gly Ile Ser Lys 
        915                 920                 925             


Pro Asn Lys Tyr Gly Thr Ala Asp Asp Leu Val Lys Ala Ile Lys Ala 
    930                 935                 940                 


Leu His Ser Lys Gly Ile Lys Val Met Ala Asp Trp Val Pro Asp Gln 
945                 950                 955                 960 


Met Tyr Ala Phe Pro Glu Lys Glu Val Val Thr Ala Thr Arg Val Asp 
                965                 970                 975     


Lys Tyr Gly Thr Pro Val Ala Gly Ser Gln Ile Lys Asn Thr Leu Tyr 
            980                 985                 990         


Val Val Asp Gly Lys Ser Ser Gly  Lys Asp Gln Gln Ala  Lys Tyr Gly 
        995                 1000                 1005             


Gly Ala  Phe Leu Glu Glu Leu  Gln Ala Lys Tyr Pro  Glu Leu Phe 
    1010                 1015                 1020             


Ala Arg  Lys Gln Ile Ser Thr  Gly Val Pro Met Asp  Pro Ser Val 
    1025                 1030                 1035             


Lys Ile  Lys Gln Trp Ser Ala  Lys Tyr Phe Asn Gly  Thr Asn Ile 
    1040                 1045                 1050             


Leu Gly  Arg Gly Ala Gly Tyr  Val Leu Lys Asp Gln  Ala Thr Asn 
    1055                 1060                 1065             


Thr Tyr  Phe Ser Leu Val Ser  Asp Asn Thr Phe Leu  Pro Lys Ser 
    1070                 1075                 1080             


Leu Val  Asn Pro Asn His Gly  Thr Ser Ser Ser Val  Thr Gly Leu 
    1085                 1090                 1095             


Val Phe  Asp Gly Lys Gly Tyr  Val Tyr Tyr Ser Thr  Ser Gly Tyr 
    1100                 1105                 1110             


Gln Ala  Lys Asn Thr Phe Ile  Ser Leu Gly Asn Asn  Trp Tyr Tyr 
    1115                 1120                 1125             


Phe Asp  Asn Asn Gly Tyr Met  Val Thr Gly Ala Gln  Ser Ile Asn 
    1130                 1135                 1140             


Gly Ala  Asn Tyr Tyr Phe Leu  Ser Asn Gly Ile Gln  Leu Arg Asn 
    1145                 1150                 1155             


Ala Ile  Tyr Asp Asn Gly Asn  Lys Val Leu Ser Tyr  Tyr Gly Asn 
    1160                 1165                 1170             


Asp Gly  Arg Arg Tyr Glu Asn  Gly Tyr Tyr Leu Phe  Gly Gln Gln 
    1175                 1180                 1185             


Trp Arg  Tyr Phe Gln Asn Gly  Ile Met Ala Val Gly  Leu Thr Arg 
    1190                 1195                 1200             


Val His  Gly Ala Val Gln Tyr  Phe Asp Ala Ser Gly  Phe Gln Ala 
    1205                 1210                 1215             


Lys Gly  Gln Phe Ile Thr Thr  Ala Asp Gly Lys Leu  Arg Tyr Phe 
    1220                 1225                 1230             


Asp Arg  Asp Ser Gly Asn Gln  Ile Ser Asn Arg Phe  Val Arg Asn 
    1235                 1240                 1245             


Ser Lys  Gly Glu Trp Phe Leu  Phe Asp His Asn Gly  Val Ala Val 
    1250                 1255                 1260             


Thr Gly  Thr Val Thr Phe Asn  Gly Gln Arg Leu Tyr  Phe Lys Pro 
    1265                 1270                 1275             


Asn Gly  Val Gln Ala Lys Gly  Glu Phe Ile Arg Asp  Ala Asp Gly 
    1280                 1285                 1290             


His Leu  Arg Tyr Tyr Asp Pro  Asn Ser Gly Asn Glu  Val Arg Asn 
    1295                 1300                 1305             


Arg Phe  Val Arg Asn Ser Lys  Gly Glu Trp Phe Leu  Phe Asp His 
    1310                 1315                 1320             


Asn Gly  Ile Ala Val Thr Gly  Ala Arg Val Val Asn  Gly Gln Arg 
    1325                 1330                 1335             


Leu Tyr  Phe Lys Ser Asn Gly  Val Gln Ala Lys Gly  Glu Leu Ile 
    1340                 1345                 1350             


Thr Glu  Arg Lys Gly Arg Ile  Lys Tyr Tyr Asp Pro  Asn Ser Gly 
    1355                 1360                 1365             


Asn Glu  Val Arg Asn Arg Tyr  Val Arg Thr Ser Ser  Gly Asn Trp 
    1370                 1375                 1380             


Tyr Tyr  Phe Gly Asn Asp Gly  Tyr Ala Leu Ile Gly  Trp His Val 
    1385                 1390                 1395             


Val Glu  Gly Arg Arg Val Tyr  Phe Asp Glu Asn Gly  Val Tyr Arg 
    1400                 1405                 1410             


Tyr Ala  Ser His Asp Gln Arg  Asn His Trp Asn Tyr  Asp Tyr Arg 
    1415                 1420                 1425             


Arg Asp  Phe Gly Arg Gly Ser  Ser Ser Ala Ile Arg  Phe Arg His 
    1430                 1435                 1440             


Ser Arg  Asn Gly Phe Phe Asp  Asn Phe Phe Arg Phe  
    1445                 1450                 1455 


<210>  44
<211>  2715
<212>  DNA
<213>  Streptococcus mutans

<400>  44
gtgaacggca aatactacta ctacaaagaa gatggaacat tacagaaaaa ctacgcactg       60

aatatcaacg gcaaaacatt tttctttgat gaaacgggag cgttatccaa taacacattg      120

ccgagcaaaa aaggcaacat cacgaacaac gataacacaa actcctttgc tcaatataac      180

caggtgtact caacggatgc agcgaatttt gaacatgtcg accattatct gacagccgaa      240

tcctggtatc gccctaaata catccttaaa gatggaaaaa catggacgca gtctacagaa      300

aaagacttta gaccgctgct tatgacgtgg tggcctgatc aagaaacaca acgccagtat      360

gtcaattaca tgaacgccca actgggcatc catcagacat ataacacagc aacgagcccg      420

ctgcagctta atttagctgc ccaaacgatc cagacaaaaa tcgaagaaaa aatcacggct      480

gagaaaaata caaactggtt gagacaaacg atcagcgcat ttgttaaaac acagtctgcg      540

tggaatagcg attctgaaaa accgtttgat gaccatttgc aaaaaggagc attgttgtat      600

tccaacaact caaaactgac gtcccaggca aattcaaact accgtatctt gaaccggaca      660

ccgacgaatc aaacaggcaa aaaagatcct agatatacgg cggaccgcac aattggcgga      720

tacgaatttc tgcttgctaa cgatgttgac aattctaacc cggttgtgca agccgaacag      780

ttgaactggc tgcattttct tatgaacttt ggaaacatct acgcgaacga tcctgacgct      840

aattttgatt caattagagt cgatgccgta gacaatgttg atgcagactt attgcaaatc      900

gcgggagatt atcttaaagc agcgaaaggt attcataaaa acgataaagc tgccaatgac      960

catttaagca tcttggaagc atggtcttat aatgatacac cgtacttaca tgatgacgga     1020

gataacatga tcaacatgga caaccgtttg cggctgagcc tgctttattc tttagccaaa     1080

ccgttgaacc agcgtagcgg catgaatcct ctgatcacaa actctcttgt aaatcggacg     1140

gatgacaacg ctgaaacagc agcggttccg tcctattcat ttattagagc ccatgattct     1200

gaagtgcaag accttatcag aaatattatc cgcgcagaaa ttaatcctaa cgtcgtaggc     1260

tactcattta cgatggaaga aatcaaaaaa gcgtttgaaa tctacaacaa agatttattg     1320

gctacagaga aaaaatatac gcattacaac acagcgttaa gctatgctct gcttttaacg     1380

aataaatcaa gcgtgccgag agtctattac ggcgatatgt ttacagatga cggacagtat     1440

atggctcata aaacgatcaa ctacgaagct atcgaaacat tgctgaaagc cagaattaaa     1500

tatgtctctg gtggccaagc catgcgcaac caacaagtgg gaaattccga aattatcacg     1560

tcagtccgtt atggcaaagg agcgcttaaa gctacagata cgggcgacag aacaacgcgc     1620

acatcaggag tggcagtcat cgaaggcaat aacccgtccc ttagattaaa agcgtcagat     1680

cgcgttgtgg tcaacatggg agctgcccat aaaaatcagg cttatcggcc tcttttattg     1740

acaacggata atggcattaa agcctatcat tcagaccaag aagcagcggg tctggtccgt     1800

tacacgaacg atcggggcga acttatcttt acagctgccg acattaaagg atatgcaaat     1860

cctcaggttt caggctactt aggagtatgg gttcctgtgg gcgcagcggc tgatcaagac     1920

gtcagagtag ccgcatccac ggcgccgtca acagacggaa aaagcgtaca tcagaacgcg     1980

gctctggata gccgcgttat gtttgaaggc ttttctaact ttcaagcctt tgcaacgaaa     2040

aaagaagaat acacaaacgt agttatcgca aaaaatgtag ataaatttgc ggaatgggga     2100

gttacggact ttgaaatggc gccgcagtat gtatcttcca cagatggcag ctttctggac     2160

tctgttatcc aaaacggata tgcatttacg gatagatacg accttggcat ctcaaaacct     2220

aacaaatacg gaacagcgga tgacctggtt aaagccatca aagcacttca tagcaaaggc     2280

attaaagtaa tggcagattg ggttccggac cagatgtatg cgtttcctga aaaagaagtg     2340

gtcacagcta cgcgcgtaga taaatatggt acgccggttg ctggcagcca aatcaaaaac     2400

acactgtacg tagttgatgg caaatcaagc ggaaaagacc aacaggccaa atatggaggt     2460

gcatttctgg aagaacttca agctaaatac cctgaacttt ttgcccgtaa acagatctct     2520

acaggagtgc cgatggaccc gtccgtcaaa atcaaacagt ggtcagcaaa atactttaac     2580

ggcacaaaca tcttaggtcg gggcgcagga tatgtgttga aagaccaagc gacaaacacg     2640

tactttagcc tggtgtctga taatacattt ctgccgaaat cacttgtcaa tcctaaccat     2700

ggaacgtctt cctaa                                                      2715


<210>  45
<211>  904
<212>  PRT
<213>  Streptococcus mutans

<400>  45

Val Asn Gly Lys Tyr Tyr Tyr Tyr Lys Glu Asp Gly Thr Leu Gln Lys 
1               5                   10                  15      


Asn Tyr Ala Leu Asn Ile Asn Gly Lys Thr Phe Phe Phe Asp Glu Thr 
            20                  25                  30          


Gly Ala Leu Ser Asn Asn Thr Leu Pro Ser Lys Lys Gly Asn Ile Thr 
        35                  40                  45              


Asn Asn Asp Asn Thr Asn Ser Phe Ala Gln Tyr Asn Gln Val Tyr Ser 
    50                  55                  60                  


Thr Asp Ala Ala Asn Phe Glu His Val Asp His Tyr Leu Thr Ala Glu 
65                  70                  75                  80  


Ser Trp Tyr Arg Pro Lys Tyr Ile Leu Lys Asp Gly Lys Thr Trp Thr 
                85                  90                  95      


Gln Ser Thr Glu Lys Asp Phe Arg Pro Leu Leu Met Thr Trp Trp Pro 
            100                 105                 110         


Asp Gln Glu Thr Gln Arg Gln Tyr Val Asn Tyr Met Asn Ala Gln Leu 
        115                 120                 125             


Gly Ile His Gln Thr Tyr Asn Thr Ala Thr Ser Pro Leu Gln Leu Asn 
    130                 135                 140                 


Leu Ala Ala Gln Thr Ile Gln Thr Lys Ile Glu Glu Lys Ile Thr Ala 
145                 150                 155                 160 


Glu Lys Asn Thr Asn Trp Leu Arg Gln Thr Ile Ser Ala Phe Val Lys 
                165                 170                 175     


Thr Gln Ser Ala Trp Asn Ser Asp Ser Glu Lys Pro Phe Asp Asp His 
            180                 185                 190         


Leu Gln Lys Gly Ala Leu Leu Tyr Ser Asn Asn Ser Lys Leu Thr Ser 
        195                 200                 205             


Gln Ala Asn Ser Asn Tyr Arg Ile Leu Asn Arg Thr Pro Thr Asn Gln 
    210                 215                 220                 


Thr Gly Lys Lys Asp Pro Arg Tyr Thr Ala Asp Arg Thr Ile Gly Gly 
225                 230                 235                 240 


Tyr Glu Phe Leu Leu Ala Asn Asp Val Asp Asn Ser Asn Pro Val Val 
                245                 250                 255     


Gln Ala Glu Gln Leu Asn Trp Leu His Phe Leu Met Asn Phe Gly Asn 
            260                 265                 270         


Ile Tyr Ala Asn Asp Pro Asp Ala Asn Phe Asp Ser Ile Arg Val Asp 
        275                 280                 285             


Ala Val Asp Asn Val Asp Ala Asp Leu Leu Gln Ile Ala Gly Asp Tyr 
    290                 295                 300                 


Leu Lys Ala Ala Lys Gly Ile His Lys Asn Asp Lys Ala Ala Asn Asp 
305                 310                 315                 320 


His Leu Ser Ile Leu Glu Ala Trp Ser Tyr Asn Asp Thr Pro Tyr Leu 
                325                 330                 335     


His Asp Asp Gly Asp Asn Met Ile Asn Met Asp Asn Arg Leu Arg Leu 
            340                 345                 350         


Ser Leu Leu Tyr Ser Leu Ala Lys Pro Leu Asn Gln Arg Ser Gly Met 
        355                 360                 365             


Asn Pro Leu Ile Thr Asn Ser Leu Val Asn Arg Thr Asp Asp Asn Ala 
    370                 375                 380                 


Glu Thr Ala Ala Val Pro Ser Tyr Ser Phe Ile Arg Ala His Asp Ser 
385                 390                 395                 400 


Glu Val Gln Asp Leu Ile Arg Asn Ile Ile Arg Ala Glu Ile Asn Pro 
                405                 410                 415     


Asn Val Val Gly Tyr Ser Phe Thr Met Glu Glu Ile Lys Lys Ala Phe 
            420                 425                 430         


Glu Ile Tyr Asn Lys Asp Leu Leu Ala Thr Glu Lys Lys Tyr Thr His 
        435                 440                 445             


Tyr Asn Thr Ala Leu Ser Tyr Ala Leu Leu Leu Thr Asn Lys Ser Ser 
    450                 455                 460                 


Val Pro Arg Val Tyr Tyr Gly Asp Met Phe Thr Asp Asp Gly Gln Tyr 
465                 470                 475                 480 


Met Ala His Lys Thr Ile Asn Tyr Glu Ala Ile Glu Thr Leu Leu Lys 
                485                 490                 495     


Ala Arg Ile Lys Tyr Val Ser Gly Gly Gln Ala Met Arg Asn Gln Gln 
            500                 505                 510         


Val Gly Asn Ser Glu Ile Ile Thr Ser Val Arg Tyr Gly Lys Gly Ala 
        515                 520                 525             


Leu Lys Ala Thr Asp Thr Gly Asp Arg Thr Thr Arg Thr Ser Gly Val 
    530                 535                 540                 


Ala Val Ile Glu Gly Asn Asn Pro Ser Leu Arg Leu Lys Ala Ser Asp 
545                 550                 555                 560 


Arg Val Val Val Asn Met Gly Ala Ala His Lys Asn Gln Ala Tyr Arg 
                565                 570                 575     


Pro Leu Leu Leu Thr Thr Asp Asn Gly Ile Lys Ala Tyr His Ser Asp 
            580                 585                 590         


Gln Glu Ala Ala Gly Leu Val Arg Tyr Thr Asn Asp Arg Gly Glu Leu 
        595                 600                 605             


Ile Phe Thr Ala Ala Asp Ile Lys Gly Tyr Ala Asn Pro Gln Val Ser 
    610                 615                 620                 


Gly Tyr Leu Gly Val Trp Val Pro Val Gly Ala Ala Ala Asp Gln Asp 
625                 630                 635                 640 


Val Arg Val Ala Ala Ser Thr Ala Pro Ser Thr Asp Gly Lys Ser Val 
                645                 650                 655     


His Gln Asn Ala Ala Leu Asp Ser Arg Val Met Phe Glu Gly Phe Ser 
            660                 665                 670         


Asn Phe Gln Ala Phe Ala Thr Lys Lys Glu Glu Tyr Thr Asn Val Val 
        675                 680                 685             


Ile Ala Lys Asn Val Asp Lys Phe Ala Glu Trp Gly Val Thr Asp Phe 
    690                 695                 700                 


Glu Met Ala Pro Gln Tyr Val Ser Ser Thr Asp Gly Ser Phe Leu Asp 
705                 710                 715                 720 


Ser Val Ile Gln Asn Gly Tyr Ala Phe Thr Asp Arg Tyr Asp Leu Gly 
                725                 730                 735     


Ile Ser Lys Pro Asn Lys Tyr Gly Thr Ala Asp Asp Leu Val Lys Ala 
            740                 745                 750         


Ile Lys Ala Leu His Ser Lys Gly Ile Lys Val Met Ala Asp Trp Val 
        755                 760                 765             


Pro Asp Gln Met Tyr Ala Phe Pro Glu Lys Glu Val Val Thr Ala Thr 
    770                 775                 780                 


Arg Val Asp Lys Tyr Gly Thr Pro Val Ala Gly Ser Gln Ile Lys Asn 
785                 790                 795                 800 


Thr Leu Tyr Val Val Asp Gly Lys Ser Ser Gly Lys Asp Gln Gln Ala 
                805                 810                 815     


Lys Tyr Gly Gly Ala Phe Leu Glu Glu Leu Gln Ala Lys Tyr Pro Glu 
            820                 825                 830         


Leu Phe Ala Arg Lys Gln Ile Ser Thr Gly Val Pro Met Asp Pro Ser 
        835                 840                 845             


Val Lys Ile Lys Gln Trp Ser Ala Lys Tyr Phe Asn Gly Thr Asn Ile 
    850                 855                 860                 


Leu Gly Arg Gly Ala Gly Tyr Val Leu Lys Asp Gln Ala Thr Asn Thr 
865                 870                 875                 880 


Tyr Phe Ser Leu Val Ser Asp Asn Thr Phe Leu Pro Lys Ser Leu Val 
                885                 890                 895     


Asn Pro Asn His Gly Thr Ser Ser 
            900                 


<210>  46
<211>  1308
<212>  DNA
<213>  Penicillium marneffei

<400>  46
atgaagcaaa ccacttccct cctcctctca gccatcgcgg caaccagcag cttcagcgga       60

ctaacagccg ctcaaaaact cgcctttgcg cacgtcgtcg tcggcaacac tgcagcacac      120

acccaatcca cctgggaaag cgacattact ctcgcccata actccggtct agatgccttt      180

gccttgaacg gtggattccc cgatggcaac atccccgcac aaatcgccaa cgcttttgcg      240

gcttgtgaag ccctttcaaa tggcttcaag ctattcattt cgtttgacta cctcggtggt      300

ggtcagccct ggcctgcctc agaggttgtg tctatgctga agcagtatgc cagttccgat      360

tgttatttgg cctatgatgg caagcccttt gtctcaactt ttgagggcac cggaaatatt      420

gcggattggg cgcacggagg tcccattcgg tcggcggtgg atgtttactt tgtgccggat      480

tggacgagtt tggggcctgc tgggattaag tcgtatctcg acaatatcga tggatttttc      540

agctggaaca tgtggcctgt aggtgcggcc gatatgaccg acgagcctga tttcgaatgg      600

ctcgatgcaa ttgggtccga caagacgtac atgatgggcg tttcgccatg gttcttccac      660

agtgcaagcg gaggcaccga ctgggtctgg cgtggtgatg acctctggga tgaccgatgg      720

attcaagtca cctgcgtcga ccctcaattt gtccaggtcg tcacatggaa cgactggggt      780

gaatcctcct acatcggccc cttcgtgacc gctagcgaag tccccgccgg ctcattagcc      840

tacgtcgaca acatgtcaca ccaaagcttc cttgacttct tgcctttcta catcgccacc      900

ttcaaaggcg acacattcaa catctcccgc gaccagatgc aatactggta ccgcctcgca      960

cccgccgcag caggcagcgc gtgcggcgta tacggcaatg atcccgatca aggccagact     1020

accgttgacg tcaactccat cgttcaggac aaggtgtttt tcagtgcttt gttgacggct     1080

gatgctactg taacggtgca gattggtagt aatgctgcgg tttcatatga tggtgttgct     1140

ggtatgaacc actggagtca ggactttaat ggccagaccg gcgcggttac gtttagtgtt     1200

gtcaggggtg gcgctacagt taagagtggt attggagccg agattacggc ttcgacttcg     1260

ttgtcgaatg ggtgcactaa ttacaaccct tgggttggta gtttctaa                  1308


<210>  47
<211>  435
<212>  PRT
<213>  Penicillium marneffei

<400>  47

Met Lys Gln Thr Thr Ser Leu Leu Leu Ser Ala Ile Ala Ala Thr Ser 
1               5                   10                  15      


Ser Phe Ser Gly Leu Thr Ala Ala Gln Lys Leu Ala Phe Ala His Val 
            20                  25                  30          


Val Val Gly Asn Thr Ala Ala His Thr Gln Ser Thr Trp Glu Ser Asp 
        35                  40                  45              


Ile Thr Leu Ala His Asn Ser Gly Leu Asp Ala Phe Ala Leu Asn Gly 
    50                  55                  60                  


Gly Phe Pro Asp Gly Asn Ile Pro Ala Gln Ile Ala Asn Ala Phe Ala 
65                  70                  75                  80  


Ala Cys Glu Ala Leu Ser Asn Gly Phe Lys Leu Phe Ile Ser Phe Asp 
                85                  90                  95      


Tyr Leu Gly Gly Gly Gln Pro Trp Pro Ala Ser Glu Val Val Ser Met 
            100                 105                 110         


Leu Lys Gln Tyr Ala Ser Ser Asp Cys Tyr Leu Ala Tyr Asp Gly Lys 
        115                 120                 125             


Pro Phe Val Ser Thr Phe Glu Gly Thr Gly Asn Ile Ala Asp Trp Ala 
    130                 135                 140                 


His Gly Gly Pro Ile Arg Ser Ala Val Asp Val Tyr Phe Val Pro Asp 
145                 150                 155                 160 


Trp Thr Ser Leu Gly Pro Ala Gly Ile Lys Ser Tyr Leu Asp Asn Ile 
                165                 170                 175     


Asp Gly Phe Phe Ser Trp Asn Met Trp Pro Val Gly Ala Ala Asp Met 
            180                 185                 190         


Thr Asp Glu Pro Asp Phe Glu Trp Leu Asp Ala Ile Gly Ser Asp Lys 
        195                 200                 205             


Thr Tyr Met Met Gly Val Ser Pro Trp Phe Phe His Ser Ala Ser Gly 
    210                 215                 220                 


Gly Thr Asp Trp Val Trp Arg Gly Asp Asp Leu Trp Asp Asp Arg Trp 
225                 230                 235                 240 


Ile Gln Val Thr Cys Val Asp Pro Gln Phe Val Gln Val Val Thr Trp 
                245                 250                 255     


Asn Asp Trp Gly Glu Ser Ser Tyr Ile Gly Pro Phe Val Thr Ala Ser 
            260                 265                 270         


Glu Val Pro Ala Gly Ser Leu Ala Tyr Val Asp Asn Met Ser His Gln 
        275                 280                 285             


Ser Phe Leu Asp Phe Leu Pro Phe Tyr Ile Ala Thr Phe Lys Gly Asp 
    290                 295                 300                 


Thr Phe Asn Ile Ser Arg Asp Gln Met Gln Tyr Trp Tyr Arg Leu Ala 
305                 310                 315                 320 


Pro Ala Ala Ala Gly Ser Ala Cys Gly Val Tyr Gly Asn Asp Pro Asp 
                325                 330                 335     


Gln Gly Gln Thr Thr Val Asp Val Asn Ser Ile Val Gln Asp Lys Val 
            340                 345                 350         


Phe Phe Ser Ala Leu Leu Thr Ala Asp Ala Thr Val Thr Val Gln Ile 
        355                 360                 365             


Gly Ser Asn Ala Ala Val Ser Tyr Asp Gly Val Ala Gly Met Asn His 
    370                 375                 380                 


Trp Ser Gln Asp Phe Asn Gly Gln Thr Gly Ala Val Thr Phe Ser Val 
385                 390                 395                 400 


Val Arg Gly Gly Ala Thr Val Lys Ser Gly Ile Gly Ala Glu Ile Thr 
                405                 410                 415     


Ala Ser Thr Ser Leu Ser Asn Gly Cys Thr Asn Tyr Asn Pro Trp Val 
            420                 425                 430         


Gly Ser Phe 
        435 


