                         SEQUENCE LISTING

<110>  ABATE-SHEN, Corinne
       CALIFANO, Andrea
       SHEN, Michael M.
 
<120>  METHOD AND COMPOSITION FOR DIAGNOSIS OR TREATMENT OF AGGRESSIVE 
       PROSTATE CANCER

<130>  P5295PC00

<150>  US 61/966,271
<151>  2014-02-19

<160>  56    

<170>  PatentIn version 3.5

<210>  1
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: FOXM1 shRNA#1

<400>  1
ataattagag gataatttg                                                    19


<210>  2
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: FOXM1 shRNA#2

<400>  2
tgatggtcat gttccggcg                                                    19


<210>  3
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CENPFshRNA#1

<400>  3
atctgattca ctcagtctg                                                    19


<210>  4
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CENPF shRNA#2

<400>  4
tttcttccaa cagtaactg                                                    19


<210>  5
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: FOXM1 forward primer

<400>  5
cgtcggccac tgattctcaa a                                                 21


<210>  6
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CENPF forward primer

<400>  6
ctctcccgtc aacagcgttc                                                   20


<210>  7
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: BRCA1 forward primer

<400>  7
gctcgtggaa gatttcggtg t                                                 21


<210>  8
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: BUB1 forward primer

<400>  8
aaatgaccct ctggatgttt gg                                                22


<210>  9
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KI67 forward primer

<400>  9
gggccaatcc tgtcgcttaa t                                                 21


<210>  10
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CYCLIN A2 forward primer

<400>  10
cgctggcggt actgaagtc                                                    19


<210>  11
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: TIMELESS forward primer

<400>  11
tctgatccgc tatttgaggc a                                                 21


<210>  12
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CDC25 forward primer

<400>  12
acgcacctat ccctgtctc                                                    19


<210>  13
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: TRIP13 forward primer

<400>  13
actgttgcac ttcacatttt cc                                                22


<210>  14
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: PLK1 forward primer

<400>  14
aaagagatcc cggaggtcct a                                                 21


<210>  15
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: HMMR forward primer

<400>  15
atgatggcta agcaagaagg c                                                 21


<210>  16
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: MYBL2 forward primer

<400>  16
ccggagcaga gggatagca                                                    19


<210>  17
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: ACTIN forward primer

<400>  17
gtctgccttg gtagtggata atg                                               23


<210>  18
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: GAPDH forward primer

<400>  18
tgtgggcatc aatggatttg g                                                 21


<210>  19
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: FOXM1 reverse primer

<400>  19
ggcaggggat ctcttaggtt c                                                 21


<210>  20
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CENPF reverse primer

<400>  20
gttgtgcata ttcttggctt gc                                                22


<210>  21
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: BRCA1 reverse primer

<400>  21
tcatcaatca cggacgtatc atc                                               23


<210>  22
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: BUB1 reverse primer

<400>  22
gcataaacgc cctaatttaa gcc                                               23


<210>  23
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: KI67 reverse primer

<400>  23
gttatgcgct tgcgaacct                                                    19


<210>  24
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CYCLIN A2 reverse primer

<400>  24
gaggaacggt gacatgctca t                                                 21


<210>  25
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: TIMELESS reverse primer

<400>  25
ggcagaaggt cgctctgtag                                                   20


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CDC25 reverse primer

<400>  26
ctggaagcgt ctgatggcaa                                                   20


<210>  27
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: TRIP13 reverse primer

<400>  27
tcgaggagat gggatttgac t                                                 21


<210>  28
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: PLK1 reverse primer

<400>  28
ggctgcggtg aatggatatt tc                                                22


<210>  29
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: HMMR reverse primer

<400>  29
tttcccttga gactcttcga ga                                                22


<210>  30
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: MYBL2 reverse primer

<400>  30
cagtgcggtt agggaagtgg                                                   20


<210>  31
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: ACTIN reverse primer

<400>  31
tcgaggacgc cctatcatgg                                                   20


<210>  32
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: GAPDH reverse primer

<400>  32
acaccatgta ttccgggtca at                                                22


<210>  33
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: FOXM1 forward primer

<400>  33
ccggagcttt cagtttgttc                                                   20


<210>  34
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CENPF forward primer

<400>  34
cacctccagt agaggggctt g                                                 21


<210>  35
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: AURKA forward primer

<400>  35
aggacaaggg ccttcttagg                                                   20


<210>  36
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: AURKB forward primer

<400>  36
ggggtccaag gcactgctac                                                   20


<210>  37
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: BIRC5 forward primer

<400>  37
ccattaaccg ccagatttga                                                   20


<210>  38
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CDC25 forward primer

<400>  38
aagagcccat cagttccgct tg                                                22


<210>  39
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: PLK1 forward primer

<400>  39
ccagagggag aagatgtcca                                                   20


<210>  40
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CYCLIN B2 forward primer

<400>  40
tcctttgccg aaagctagag                                                   20


<210>  41
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: FOXM1 reverse primer

<400>  41
cggaatgccg agacaagg                                                     18


<210>  42
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CENPF reverse primer

<400>  42
tacctccacg cctattggtc                                                   20


<210>  43
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: AURKA reverse primer

<400>  43
tagtgggtgg ggagacagac                                                   20


<210>  44
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: AURKB reverse primer

<400>  44
ggggcgggag atttgaaaag                                                   20


<210>  45
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: BIRC5 reverse primer

<400>  45
tgtagagatg cggtggtcct                                                   20


<210>  46
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CDC25 reverse primer

<400>  46
cccattttac agacctggac gc                                                22


<210>  47
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: PLK1 reverse primer

<400>  47
gtcgttgtcc tcgaaaaagc                                                   20


<210>  48
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: CYCLIN B2 reverse primer

<400>  48
gcaactgcca atctgaaaaa g                                                 21


<210>  49
<211>  3506
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human nucleic acid sequence of forkhead box M1 (FOXM1)

<400>  49
tttcaaacag cggaacaaac tgaaagctcc ggtgccagac cccacccccg gccccggccc       60

gggaccccct cccctcccgg gatcccccgg ggttcccacc ccgcccgcac cgccggggac      120

ccggccggtc cggcgcgagc ccccgtccgg ggccctggct cggcccccag gttggaggag      180

cccggagccc gccttcggag ctacggccta acggcggcgg cgactgcagt ctggagggtc      240

cacacttgtg attctcaatg gagagtgaaa acgcagattc ataatgaaaa ctagcccccg      300

tcggccactg attctcaaaa gacggaggct gccccttcct gttcaaaatg ccccaagtga      360

aacatcagag gaggaaccta agagatcccc tgcccaacag gagtctaatc aagcagaggc      420

ctccaaggaa gtggcagagt ccaactcttg caagtttcca gctgggatca agattattaa      480

ccaccccacc atgcccaaca cgcaagtagt ggccatcccc aacaatgcta atattcacag      540

catcatcaca gcactgactg ccaagggaaa agagagtggc agtagtgggc ccaacaaatt      600

catcctcatc agctgtgggg gagccccaac tcagcctcca ggactccggc ctcaaaccca      660

aaccagctat gatgccaaaa ggacagaagt gaccctggag accttgggac caaaacctgc      720

agctagggat gtgaatcttc ctagaccacc tggagccctt tgcgagcaga aacgggagac      780

ctgtgatggt gaggcagcag gctgcactat caacaatagc ctatccaaca tccagtggct      840

tcgaaagatg agttctgatg gactgggctc ccgcagcatc aagcaagaga tggaggaaaa      900

ggagaattgt cacctggagc agcgacaggt taaggttgag gagccttcga gaccatcagc      960

gtcctggcag aactctgtgt ctgagcggcc accctactct tacatggcca tgatacaatt     1020

cgccatcaac agcactgaga ggaagcgcat gactttgaaa gacatctata cgtggattga     1080

ggaccacttt ccctacttta agcacattgc caagccaggc tggaagaact ccatccgcca     1140

caacctttcc ctgcacgaca tgtttgtccg ggagacgtct gccaatggca aggtctcctt     1200

ctggaccatt caccccagtg ccaaccgcta cttgacattg gaccaggtgt ttaagcagca     1260

gcagaaacga ccgaatccag agctccgccg gaacatgacc atcaaaaccg aactccccct     1320

gggcgcacgg cggaagatga agccactgct accacgggtc agctcatacc tggtacctat     1380

ccagttcccg gtgaaccagt cactggtgtt gcagccctcg gtgaaggtgc cattgcccct     1440

ggcggcttcc ctcatgagct cagagcttgc ccgccatagc aagcgagtcc gcattgcccc     1500

caaggtgctg ctagctgagg aggggatagc tcctctttct tctgcaggac cagggaaaga     1560

ggagaaactc ctgtttggag aagggttttc tcctttgctt ccagttcaga ctatcaagga     1620

ggaagaaatc cagcctgggg aggaaatgcc acacttagcg agacccatca aagtggagag     1680

ccctcccttg gaagagtggc cctccccggc cccatctttc aaagaggaat catctcactc     1740

ctgggaggat tcgtcccaat ctcccacccc aagacccaag aagtcctaca gtgggcttag     1800

gtccccaacc cggtgtgtct cggaaatgct tgtgattcaa cacagggaga ggagggagag     1860

gagccggtct cggaggaaac agcatctact gcctccctgt gtggatgagc cggagctgct     1920

cttctcagag gggcccagta cttcccgctg ggccgcagag ctcccgttcc cagcagactc     1980

ctctgaccct gcctcccagc tcagctactc ccaggaagtg ggaggacctt ttaagacacc     2040

cattaaggaa acgctgccca tctcctccac cccgagcaaa tctgtcctcc ccagaacccc     2100

tgaatcctgg aggctcacgc ccccagccaa agtaggggga ctggatttca gcccagtaca     2160

aacctcccag ggtgcctctg accccttgcc tgaccccctg gggctgatgg atctcagcac     2220

cactcccttg caaagtgctc ccccccttga atcaccgcaa aggctcctca gttcagaacc     2280

cttagacctc atctccgtcc cctttggcaa ctcttctccc tcagatatag acgtccccaa     2340

gccaggctcc ccggagccac aggtttctgg ccttgcagcc aatcgttctc tgacagaagg     2400

cctggtcctg gacacaatga atgacagcct cagcaagatc ctgctggaca tcagctttcc     2460

tggcctggac gaggacccac tgggccctga caacatcaac tggtcccagt ttattcctga     2520

gctacagtag agccctgccc ttgcccctgt gctcaagctg tccaccatcc cgggcactcc     2580

aaggctcagt gcaccccaag cctctgagtg aggacagcag gcagggactg ttctgctcct     2640

catagctccc tgctgcctga ttatgcaaaa gtagcagtca caccctagcc actgctggga     2700

ccttgtgttc cccaagagta tctgattcct ctgctgtccc tgccaggagc tgaagggtgg     2760

gaacaacaaa ggcaatggtg aaaagagatt aggaaccccc cagcctgttt ccattctctg     2820

cccagcagtc tcttaccttc cctgatcttt gcagggtggt ccgtgtaaat agtataaatt     2880

ctccaaatta tcctctaatt ataaatgtaa gcttatttcc ttagatcatt atccagagac     2940

tgccagaagg tgggtaggat gacctggggt ttcaattgac ttctgttcct tgcttttagt     3000

tttgatagaa gggaagacct gcagtgcacg gtttcttcca ggctgaggta cctggatctt     3060

gggttcttca ctgcagggac ccagacaagt ggatctgctt gccagagtcc tttttgcccc     3120

tccctgccac ctccccgtgt ttccaagtca gctttcctgc aagaagaaat cctggttaaa     3180

aaagtctttt gtattgggtc aggagttgaa tttggggtgg gaggatggat gcaactgaag     3240

cagagtgtgg gtgcccagat gtgcgctatt agatgtttct ctgataatgt ccccaatcat     3300

accagggaga ctggcattga cgagaactca ggtggaggct tgagaaggcc gaaagggccc     3360

ctgacctgcc tggcttcctt agcttgcccc tcagctttgc aaagagccac cctaggcccc     3420

agctgaccgc atgggtgtga gccagcttga gaacactaac tactcaataa aagcgaaggt     3480

ggacatgaaa aaaaaaaaaa aaaaaa                                          3506


<210>  50
<211>  748
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human forkhead box protein M1 isoform 4

<400>  50

Met Lys Thr Ser Pro Arg Arg Pro Leu Ile Leu Lys Arg Arg Arg Leu 
1               5                   10                  15      


Pro Leu Pro Val Gln Asn Ala Pro Ser Glu Thr Ser Glu Glu Glu Pro 
            20                  25                  30          


Lys Arg Ser Pro Ala Gln Gln Glu Ser Asn Gln Ala Glu Ala Ser Lys 
        35                  40                  45              


Glu Val Ala Glu Ser Asn Ser Cys Lys Phe Pro Ala Gly Ile Lys Ile 
    50                  55                  60                  


Ile Asn His Pro Thr Met Pro Asn Thr Gln Val Val Ala Ile Pro Asn 
65                  70                  75                  80  


Asn Ala Asn Ile His Ser Ile Ile Thr Ala Leu Thr Ala Lys Gly Lys 
                85                  90                  95      


Glu Ser Gly Ser Ser Gly Pro Asn Lys Phe Ile Leu Ile Ser Cys Gly 
            100                 105                 110         


Gly Ala Pro Thr Gln Pro Pro Gly Leu Arg Pro Gln Thr Gln Thr Ser 
        115                 120                 125             


Tyr Asp Ala Lys Arg Thr Glu Val Thr Leu Glu Thr Leu Gly Pro Lys 
    130                 135                 140                 


Pro Ala Ala Arg Asp Val Asn Leu Pro Arg Pro Pro Gly Ala Leu Cys 
145                 150                 155                 160 


Glu Gln Lys Arg Glu Thr Cys Asp Gly Glu Ala Ala Gly Cys Thr Ile 
                165                 170                 175     


Asn Asn Ser Leu Ser Asn Ile Gln Trp Leu Arg Lys Met Ser Ser Asp 
            180                 185                 190         


Gly Leu Gly Ser Arg Ser Ile Lys Gln Glu Met Glu Glu Lys Glu Asn 
        195                 200                 205             


Cys His Leu Glu Gln Arg Gln Val Lys Val Glu Glu Pro Ser Arg Pro 
    210                 215                 220                 


Ser Ala Ser Trp Gln Asn Ser Val Ser Glu Arg Pro Pro Tyr Ser Tyr 
225                 230                 235                 240 


Met Ala Met Ile Gln Phe Ala Ile Asn Ser Thr Glu Arg Lys Arg Met 
                245                 250                 255     


Thr Leu Lys Asp Ile Tyr Thr Trp Ile Glu Asp His Phe Pro Tyr Phe 
            260                 265                 270         


Lys His Ile Ala Lys Pro Gly Trp Lys Asn Ser Ile Arg His Asn Leu 
        275                 280                 285             


Ser Leu His Asp Met Phe Val Arg Glu Thr Ser Ala Asn Gly Lys Val 
    290                 295                 300                 


Ser Phe Trp Thr Ile His Pro Ser Ala Asn Arg Tyr Leu Thr Leu Asp 
305                 310                 315                 320 


Gln Val Phe Lys Gln Gln Gln Lys Arg Pro Asn Pro Glu Leu Arg Arg 
                325                 330                 335     


Asn Met Thr Ile Lys Thr Glu Leu Pro Leu Gly Ala Arg Arg Lys Met 
            340                 345                 350         


Lys Pro Leu Leu Pro Arg Val Ser Ser Tyr Leu Val Pro Ile Gln Phe 
        355                 360                 365             


Pro Val Asn Gln Ser Leu Val Leu Gln Pro Ser Val Lys Val Pro Leu 
    370                 375                 380                 


Pro Leu Ala Ala Ser Leu Met Ser Ser Glu Leu Ala Arg His Ser Lys 
385                 390                 395                 400 


Arg Val Arg Ile Ala Pro Lys Val Leu Leu Ala Glu Glu Gly Ile Ala 
                405                 410                 415     


Pro Leu Ser Ser Ala Gly Pro Gly Lys Glu Glu Lys Leu Leu Phe Gly 
            420                 425                 430         


Glu Gly Phe Ser Pro Leu Leu Pro Val Gln Thr Ile Lys Glu Glu Glu 
        435                 440                 445             


Ile Gln Pro Gly Glu Glu Met Pro His Leu Ala Arg Pro Ile Lys Val 
    450                 455                 460                 


Glu Ser Pro Pro Leu Glu Glu Trp Pro Ser Pro Ala Pro Ser Phe Lys 
465                 470                 475                 480 


Glu Glu Ser Ser His Ser Trp Glu Asp Ser Ser Gln Ser Pro Thr Pro 
                485                 490                 495     


Arg Pro Lys Lys Ser Tyr Ser Gly Leu Arg Ser Pro Thr Arg Cys Val 
            500                 505                 510         


Ser Glu Met Leu Val Ile Gln His Arg Glu Arg Arg Glu Arg Ser Arg 
        515                 520                 525             


Ser Arg Arg Lys Gln His Leu Leu Pro Pro Cys Val Asp Glu Pro Glu 
    530                 535                 540                 


Leu Leu Phe Ser Glu Gly Pro Ser Thr Ser Arg Trp Ala Ala Glu Leu 
545                 550                 555                 560 


Pro Phe Pro Ala Asp Ser Ser Asp Pro Ala Ser Gln Leu Ser Tyr Ser 
                565                 570                 575     


Gln Glu Val Gly Gly Pro Phe Lys Thr Pro Ile Lys Glu Thr Leu Pro 
            580                 585                 590         


Ile Ser Ser Thr Pro Ser Lys Ser Val Leu Pro Arg Thr Pro Glu Ser 
        595                 600                 605             


Trp Arg Leu Thr Pro Pro Ala Lys Val Gly Gly Leu Asp Phe Ser Pro 
    610                 615                 620                 


Val Gln Thr Ser Gln Gly Ala Ser Asp Pro Leu Pro Asp Pro Leu Gly 
625                 630                 635                 640 


Leu Met Asp Leu Ser Thr Thr Pro Leu Gln Ser Ala Pro Pro Leu Glu 
                645                 650                 655     


Ser Pro Gln Arg Leu Leu Ser Ser Glu Pro Leu Asp Leu Ile Ser Val 
            660                 665                 670         


Pro Phe Gly Asn Ser Ser Pro Ser Asp Ile Asp Val Pro Lys Pro Gly 
        675                 680                 685             


Ser Pro Glu Pro Gln Val Ser Gly Leu Ala Ala Asn Arg Ser Leu Thr 
    690                 695                 700                 


Glu Gly Leu Val Leu Asp Thr Met Asn Asp Ser Leu Ser Lys Ile Leu 
705                 710                 715                 720 


Leu Asp Ile Ser Phe Pro Gly Leu Asp Glu Asp Pro Leu Gly Pro Asp 
                725                 730                 735     


Asn Ile Asn Trp Ser Gln Phe Ile Pro Glu Leu Gln 
            740                 745             


<210>  51
<211>  4391
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Mus musculus forkhead box M1 (Foxm1), mRNA

<400>  51
gcgggaccca cccccggccc gggctccccc gtcaccccgc cccgggctcc caccccggcc       60

gtcccgccgg gacccgccgc ccgggcccgg ctcggccccg cgtggagcag acgcggcctg      120

tgagggtcaa agcttgcgat tctcgatgga gagcgaaagc acagcctcac gatgagaacc      180

agcccccgcc ggccactgat tctcaaaaga cggaggctgc cccttcctgt ccagaatgcc      240

ccgagtgaaa catcagagga agaagcaaag aggtcccctg cccagccgga gcctgctcca      300

gcacaggcct cccaagaggt ggcagagtcc agctcttgca aatttccagc cggaatcaag      360

attatcaacc accccaccac gcccaacaca caagtggtgg ccatccccag caacgctgat      420

atccagagca tcatcacagc gctaactgcc aaagggaagg agagcggcag cagcgggccc      480

aaccggttca tcctcatcag ctctgggggg ccctcctctc acccttccca gcctcaagcc      540

cacagcagcc gggattccaa gagagcagag gtgatcacgg agacgttggg accgaagcca      600

gcagctaagg gtgtgcctgt tcccaagcct cctggagccc ctccaaggca aagacaggag      660

agctatgctg gtggtgaggc ggcaggctgc acgctggaca acagcttaac caatatccag      720

tggcttggaa agatgagttc tgacgggctg ggcccctgca gcgttaagca ggaactggaa      780

gagaaggaga attgtcacct ggagcagaat cgggttaagg ttgaggagcc ctcaggagtg      840

tcaacatctt ggcaggactc tgtgtctgag aggccaccct actcttatat ggccatgata      900

cagtttgcca tcaacagcac tgagagaaag cgcatgacct tgaaggacat ctacacttgg      960

attgaggacc acttccctta ctttaagcac attgccaagc caggctggaa gaactctatt     1020

cgtcacaacc tttctctcca tgacatgttt gttcgagaga catctgccaa tggcaaggtc     1080

tccttctgga ccattcaccc aagtgccaat cgctacttga cattggacca agtgtttaag     1140

ccactggaac cagggtctcc acaatcgccc gagcacttgg aatcacagca gaaacgaccc     1200

aatcctgagc tccatagaaa tgtgaccatc aaaactgaaa tcccactggg cgcacggcga     1260

aagatgaagc ctctgctccc tcgggttagc tcatacctgg tgcccatcca gttcccagtg     1320

aaccagtccc tggtgttaca gccctcagtg aaggttccct tgcctctggc agcatcgctt     1380

atgagctcag agctcgcccg tcatagcaag cgagtccgca ttgcacccaa ggtgttgcta     1440

tccagtgaag gaatagcccc gcttcctgcc acagaaccac cgaaggagga gaaacccctg     1500

cttggagggg aagggctgtt gcctttactt cctattcagt ccattaagga agaagaaatg     1560

cagcctgagg aggacatagc acacttagag aggcctatca aagtggagag ccctcccttg     1620

gaagagtggc cctctccgtg tgcatcgctc aaagaggagc tatccaactc ctgggaagat     1680

tcttcctgct ctcctacccc aaagcccaag aagtcctact gtgggctcaa gtccccaacg     1740

cgctgtgtct cagaaatgct ggtgactaag cgaagagaga aaagggaggt gagccgatcc     1800

cggaggaaac agcaccttca gcccccctgt ctggatgagc ctgacctgtt cttctcagag     1860

gactccagca catttcggcc agccgtggag ctcctggcgg agtcttccga gcctgcaccc     1920

cacctcagct gccctcagga agagggagga cctttcaaga cccccatcaa ggagacattg     1980

cctgtctcct ccactcctag caagtctgtg ctctctagag accctgagtc ctggaggctc     2040

acacctccag ccaaagttgg ggggttagat ttcagcccag tacgaacccc ccagggtgcc     2100

tttggccttc tgcctgactc actggggttg atggagctga ataccacccc tttgaaaagt     2160

ggtcctctct ttgactcgcc ccgggagctc ctcaactcag agccctttga cctggcctct     2220

gaccccttcg gcagccctcc accaccacat gtggaaggcc ccaagcctgg ctcccccgag     2280

ctgcagattc ccagcctttc agccaaccgt tctctcacag aaggccttgt cctggacaca     2340

atgaatgata gcctcagcaa gatccttcta gacatcagtt tccctggcct ggaggaggac     2400

cctctgggcc ctgacaacat caactggtct cagttcatcc cttagctgcg atagaggcaa     2460

ggccttgccc ctgccactca agccgcctgc tatcctggca cttgtgtggc tcagggtacc     2520

ccaagccgtc tgagggaagc tagcaggcaa gggctgagct gtgccctttg acctaattat     2580

gtcaagatga tagccgcatc taagccacac caggacctat gcaagcagta ggatccccca     2640

gagtccgagt cctccactcc ctgctggcaa gtgaagtggg tgtgacgagc catgaggacc     2700

aggaagtgcc cattagtcac tcggtgctcc tggcagggta acccttataa atggtgtcag     2760

ctccccaagt tgtcctgtaa ctataaatgt aagcgtattt ccttagctca ttatccagag     2820

atggccagga tggggagagg gacggggttg cactttgctt ctgcttgtgg cctctggggg     2880

aaggacctgc agtgcagtct ctccacactg tgggttctgc tataggcttc tagagataca     2940

ggttgccgtg ccaggatcct gcttactgcc ctttcctcgc agctccccaa gtctccaagt     3000

cagtggtact gcatgaagaa atcctgctgt gaaagcctat tggattcggg tgtagggaga     3060

tgggtgtgcc tgaagcaaaa gcatgggtac tcacaggagt cctattaggt gtttctctga     3120

tagtgttccc aatcatgcca gggagtctac cactgagatc tcaggctgag gcctgagaag     3180

gagaaagtga cccctcactt gcctggcttc cttagcttgc tcctgagctt tgcaaaaaac     3240

caccctagac cccactctac aagctacaga acaacactac tgtaactacc tactaaataa     3300

agcccgtggc actggtcttg gaattgagcg agaggtggag cctgggggtg atgggcaagg     3360

cctgcccctg ctgcatgggc cttccacaga tgctctctcc cgcacccttc ttggactctg     3420

aggttgccag ctttgtctgt tgcgatgatt catatctata atctcagcct ttgagaggta     3480

gaggctggag gatcagccct ctatgctaca tgagatcctg ccaacagagt ccagttccca     3540

ctgttccctg ccctgcccac ctcttccttg ccaccccaga ccttgttcca tgggaccaga     3600

ctctgactta ggtccttgtt gatcccttgg taacaacagc agttatagtc ctccaattcc     3660

ctcccattcc attcagtatt caggcctgaa agccgaaact gttgtaggtg tctcattacc     3720

acctctatcc cagctccaag cccaggagcc agcccccttc ctgctcctga gccttcccag     3780

gcaaggctct cgctcagcag ctcctgttac caagtttgta accagaactg acagcgaaaa     3840

gcatcaggga ctgaggagcc tcccaggaca ggcaagggcc tcctcccagc agcaccagtc     3900

aggaagcatc accatagcaa ccctagcagc aaacaatggt accagaaagg gctttcctcc     3960

aaagccgcct ctcctggctc tgtggctcag aggaagaatg gccaacatcc cgaagaaaac     4020

atccctccaa aagtcaagcc tgagccaagt atctcgtacc agggagcctt tcctgaaggt     4080

agagtggggc ccaacaacgc agccagcctt tcaggttgtc ctgagcagta gtctctggta     4140

cataagccag tttctgcttt catcctgtgg taccctaagt tggagctcag aacagaaagg     4200

agaagcctgg gcaacaggtt gaagaggcct tatctaaagg acttgggatc agaaatgtgc     4260

ttagctttgg gatttacttt tggattttgg agtatgtgta tgtatgtcaa actatgttgg     4320

gcaaggaccc caaacttaat ataaaattcc tttgtttcat atgtaaaaaa aaaaaaaaaa     4380

aaaaaaaaaa a                                                          4391


<210>  52
<211>  757
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Mus musculus forkhead box protein M1

<400>  52

Met Arg Thr Ser Pro Arg Arg Pro Leu Ile Leu Lys Arg Arg Arg Leu 
1               5                   10                  15      


Pro Leu Pro Val Gln Asn Ala Pro Ser Glu Thr Ser Glu Glu Glu Ala 
            20                  25                  30          


Lys Arg Ser Pro Ala Gln Pro Glu Pro Ala Pro Ala Gln Ala Ser Gln 
        35                  40                  45              


Glu Val Ala Glu Ser Ser Ser Cys Lys Phe Pro Ala Gly Ile Lys Ile 
    50                  55                  60                  


Ile Asn His Pro Thr Thr Pro Asn Thr Gln Val Val Ala Ile Pro Ser 
65                  70                  75                  80  


Asn Ala Asp Ile Gln Ser Ile Ile Thr Ala Leu Thr Ala Lys Gly Lys 
                85                  90                  95      


Glu Ser Gly Ser Ser Gly Pro Asn Arg Phe Ile Leu Ile Ser Ser Gly 
            100                 105                 110         


Gly Pro Ser Ser His Pro Ser Gln Pro Gln Ala His Ser Ser Arg Asp 
        115                 120                 125             


Ser Lys Arg Ala Glu Val Ile Thr Glu Thr Leu Gly Pro Lys Pro Ala 
    130                 135                 140                 


Ala Lys Gly Val Pro Val Pro Lys Pro Pro Gly Ala Pro Pro Arg Gln 
145                 150                 155                 160 


Arg Gln Glu Ser Tyr Ala Gly Gly Glu Ala Ala Gly Cys Thr Leu Asp 
                165                 170                 175     


Asn Ser Leu Thr Asn Ile Gln Trp Leu Gly Lys Met Ser Ser Asp Gly 
            180                 185                 190         


Leu Gly Pro Cys Ser Val Lys Gln Glu Leu Glu Glu Lys Glu Asn Cys 
        195                 200                 205             


His Leu Glu Gln Asn Arg Val Lys Val Glu Glu Pro Ser Gly Val Ser 
    210                 215                 220                 


Thr Ser Trp Gln Asp Ser Val Ser Glu Arg Pro Pro Tyr Ser Tyr Met 
225                 230                 235                 240 


Ala Met Ile Gln Phe Ala Ile Asn Ser Thr Glu Arg Lys Arg Met Thr 
                245                 250                 255     


Leu Lys Asp Ile Tyr Thr Trp Ile Glu Asp His Phe Pro Tyr Phe Lys 
            260                 265                 270         


His Ile Ala Lys Pro Gly Trp Lys Asn Ser Ile Arg His Asn Leu Ser 
        275                 280                 285             


Leu His Asp Met Phe Val Arg Glu Thr Ser Ala Asn Gly Lys Val Ser 
    290                 295                 300                 


Phe Trp Thr Ile His Pro Ser Ala Asn Arg Tyr Leu Thr Leu Asp Gln 
305                 310                 315                 320 


Val Phe Lys Pro Leu Glu Pro Gly Ser Pro Gln Ser Pro Glu His Leu 
                325                 330                 335     


Glu Ser Gln Gln Lys Arg Pro Asn Pro Glu Leu His Arg Asn Val Thr 
            340                 345                 350         


Ile Lys Thr Glu Ile Pro Leu Gly Ala Arg Arg Lys Met Lys Pro Leu 
        355                 360                 365             


Leu Pro Arg Val Ser Ser Tyr Leu Val Pro Ile Gln Phe Pro Val Asn 
    370                 375                 380                 


Gln Ser Leu Val Leu Gln Pro Ser Val Lys Val Pro Leu Pro Leu Ala 
385                 390                 395                 400 


Ala Ser Leu Met Ser Ser Glu Leu Ala Arg His Ser Lys Arg Val Arg 
                405                 410                 415     


Ile Ala Pro Lys Val Leu Leu Ser Ser Glu Gly Ile Ala Pro Leu Pro 
            420                 425                 430         


Ala Thr Glu Pro Pro Lys Glu Glu Lys Pro Leu Leu Gly Gly Glu Gly 
        435                 440                 445             


Leu Leu Pro Leu Leu Pro Ile Gln Ser Ile Lys Glu Glu Glu Met Gln 
    450                 455                 460                 


Pro Glu Glu Asp Ile Ala His Leu Glu Arg Pro Ile Lys Val Glu Ser 
465                 470                 475                 480 


Pro Pro Leu Glu Glu Trp Pro Ser Pro Cys Ala Ser Leu Lys Glu Glu 
                485                 490                 495     


Leu Ser Asn Ser Trp Glu Asp Ser Ser Cys Ser Pro Thr Pro Lys Pro 
            500                 505                 510         


Lys Lys Ser Tyr Cys Gly Leu Lys Ser Pro Thr Arg Cys Val Ser Glu 
        515                 520                 525             


Met Leu Val Thr Lys Arg Arg Glu Lys Arg Glu Val Ser Arg Ser Arg 
    530                 535                 540                 


Arg Lys Gln His Leu Gln Pro Pro Cys Leu Asp Glu Pro Asp Leu Phe 
545                 550                 555                 560 


Phe Ser Glu Asp Ser Ser Thr Phe Arg Pro Ala Val Glu Leu Leu Ala 
                565                 570                 575     


Glu Ser Ser Glu Pro Ala Pro His Leu Ser Cys Pro Gln Glu Glu Gly 
            580                 585                 590         


Gly Pro Phe Lys Thr Pro Ile Lys Glu Thr Leu Pro Val Ser Ser Thr 
        595                 600                 605             


Pro Ser Lys Ser Val Leu Ser Arg Asp Pro Glu Ser Trp Arg Leu Thr 
    610                 615                 620                 


Pro Pro Ala Lys Val Gly Gly Leu Asp Phe Ser Pro Val Arg Thr Pro 
625                 630                 635                 640 


Gln Gly Ala Phe Gly Leu Leu Pro Asp Ser Leu Gly Leu Met Glu Leu 
                645                 650                 655     


Asn Thr Thr Pro Leu Lys Ser Gly Pro Leu Phe Asp Ser Pro Arg Glu 
            660                 665                 670         


Leu Leu Asn Ser Glu Pro Phe Asp Leu Ala Ser Asp Pro Phe Gly Ser 
        675                 680                 685             


Pro Pro Pro Pro His Val Glu Gly Pro Lys Pro Gly Ser Pro Glu Leu 
    690                 695                 700                 


Gln Ile Pro Ser Leu Ser Ala Asn Arg Ser Leu Thr Glu Gly Leu Val 
705                 710                 715                 720 


Leu Asp Thr Met Asn Asp Ser Leu Ser Lys Ile Leu Leu Asp Ile Ser 
                725                 730                 735     


Phe Pro Gly Leu Glu Glu Asp Pro Leu Gly Pro Asp Asn Ile Asn Trp 
            740                 745                 750         


Ser Gln Phe Ile Pro 
        755         


<210>  53
<211>  10316
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human centromere protein F (CENPF), mRNA

<400>  53
gagaccagaa gcgggcgaat tgggcaccgg tggcggctgc gggcagtttg aattagactc       60

tgggctccag cccgccgaag ccgcgccaga actgtactct ccgagaggtc gttttcccgt      120

ccccgagagc aagtttattt acaaatgttg gagtaataaa gaaggcagaa caaaatgagc      180

tgggctttgg aagaatggaa agaagggctg cctacaagag ctcttcagaa aattcaagag      240

cttgaaggac agcttgacaa actgaagaag gaaaagcagc aaaggcagtt tcagcttgac      300

agtctcgagg ctgcgctgca gaagcaaaaa cagaaggttg aaaatgaaaa aaccgagggt      360

acaaacctga aaagggagaa tcaaagattg atggaaatat gtgaaagtct ggagaaaact      420

aagcagaaga tttctcatga acttcaagtc aaggagtcac aagtgaattt ccaggaagga      480

caactgaatt caggcaaaaa acaaatagaa aaactggaac aggaacttaa aaggtgtaaa      540

tctgagcttg aaagaagcca acaagctgcg cagtctgcag atgtctctct gaatccatgc      600

aatacaccac aaaaaatttt tacaactcca ctaacaccaa gtcaatatta tagtggttcc      660

aagtatgaag atctaaaaga aaaatataat aaagaggttg aagaacgaaa aagattagag      720

gcagaggtta aagccttgca ggctaaaaaa gcaagccaga ctcttccaca agccaccatg      780

aatcaccgcg acattgcccg gcatcaggct tcatcatctg tgttctcatg gcagcaagag      840

aagaccccaa gtcatctttc atctaattct caaagaactc caattaggag agatttctct      900

gcatcttact tttctgggga acaagaggtg actccaagtc gatcaacttt gcaaataggg      960

aaaagagatg ctaatagcag tttctttgac aattctagca gtcctcatct tttggatcaa     1020

ttaaaagcgc agaatcaaga gctaagaaac aagattaatg agttggaact acgcctgcaa     1080

ggacatgaaa aagaaatgaa aggccaagtg aataagtttc aagaactcca actccaactg     1140

gagaaagcaa aagtggaatt aattgaaaaa gagaaagttt tgaacaaatg tagggatgaa     1200

ctagtgagaa caacagcaca atacgaccag gcgtcaacca agtatactgc attggaacaa     1260

aaactgaaaa aattgacgga agatttgagt tgtcagcgac aaaatgcaga aagtgccaga     1320

tgttctctgg aacagaaaat taaggaaaaa gaaaaggagt ttcaagagga gctctcccgt     1380

caacagcgtt ctttccaaac actggaccag gagtgcatcc agatgaaggc cagactcacc     1440

caggagttac agcaagccaa gaatatgcac aacgtcctgc aggctgaact ggataaactc     1500

acatcagtaa agcaacagct agaaaacaat ttggaagagt ttaagcaaaa gttgtgcaga     1560

gctgaacagg cgttccaggc gagtcagatc aaggagaatg agctgaggag aagcatggag     1620

gaaatgaaga aggaaaacaa cctccttaag agtcactctg agcaaaaggc cagagaagtc     1680

tgccacctgg aggcagaact caagaacatc aaacagtgtt taaatcagag ccagaatttt     1740

gcagaagaaa tgaaagcgaa gaatacctct caggaaacca tgttaagaga tcttcaagaa     1800

aaaataaatc agcaagaaaa ctccttgact ttagaaaaac tgaagcttgc tgtggctgat     1860

ctggaaaagc agcgagattg ttctcaagac cttttgaaga aaagagaaca tcacattgaa     1920

caacttaatg ataagttaag caagacagag aaagagtcca aagccttgct gagtgcttta     1980

gagttaaaaa agaaagaata tgaagaattg aaagaagaga aaactctgtt ttcttgttgg     2040

aaaagtgaaa acgaaaaact tttaactcag atggaatcag aaaaggaaaa cttgcagagt     2100

aaaattaatc acttggaaac ttgtctgaag acacagcaaa taaaaagtca tgaatacaac     2160

gagagagtaa gaacgctgga gatggacaga gaaaacctaa gtgtcgagat cagaaacctt     2220

cacaacgtgt tagacagtaa gtcagtggag gtagagaccc agaaactagc ttatatggag     2280

ctacagcaga aagctgagtt ctcagatcag aaacatcaga aggaaataga aaatatgtgt     2340

ttgaagactt ctcagcttac tgggcaagtt gaagatctag aacacaagct tcagttactg     2400

tcaaatgaaa taatggacaa agaccggtgt taccaagact tgcatgccga atatgagagc     2460

ctcagggatc tgctaaaatc caaagatgct tctctggtga caaatgaaga tcatcagaga     2520

agtcttttgg cttttgatca gcagcctgcc atgcatcatt cctttgcaaa tataattgga     2580

gaacaaggaa gcatgccttc agagaggagt gaatgtcgtt tagaagcaga ccaaagtccg     2640

aaaaattctg ccatcctaca aaatagagtt gattcacttg aattttcatt agagtctcaa     2700

aaacagatga actcagacct gcaaaagcag tgtgaagagt tggtgcaaat caaaggagaa     2760

atagaagaaa atctcatgaa agcagaacag atgcatcaaa gttttgtggc tgaaacaagt     2820

cagcgcatta gtaagttaca ggaagacact tctgctcacc agaatgttgt tgctgaaacc     2880

ttaagtgccc ttgagaacaa ggaaaaagag ctgcaacttt taaatgataa ggtagaaact     2940

gagcaggcag agattcaaga attaaaaaag agcaaccatc tacttgaaga ctctctaaag     3000

gagctacaac ttttatccga aaccctaagc ttggagaaga aagaaatgag ttccatcatt     3060

tctctaaata aaagggaaat tgaagagctg acccaagaga atgggactct taaggaaatt     3120

aatgcatcct taaatcaaga gaagatgaac ttaatccaga aaagtgagag ttttgcaaac     3180

tatatagatg aaagggagaa aagcatttca gagttatctg atcagtacaa gcaagaaaaa     3240

cttattttac tacaaagatg tgaagaaacc ggaaatgcat atgaggatct tagtcaaaaa     3300

tacaaagcag cacaggaaaa gaattctaaa ttagaatgct tgctaaatga atgcactagt     3360

ctttgtgaaa ataggaaaaa tgagttggaa cagctaaagg aagcatttgc aaaggaacac     3420

caagaattct taacaaaatt agcatttgct gaagaaagaa atcagaatct gatgctagag     3480

ttggagacag tgcagcaagc tctgagatct gagatgacag ataaccaaaa caattctaag     3540

agcgaggctg gtggtttaaa gcaagaaatc atgactttaa aggaagaaca aaacaaaatg     3600

caaaaggaag ttaatgactt attacaagag aatgaacagc tgatgaaggt aatgaagact     3660

aaacatgaat gtcaaaatct agaatcagaa ccaattagga actctgtgaa agaaagagag     3720

agtgagagaa atcaatgtaa ttttaaacct cagatggatc ttgaagttaa agaaatttct     3780

ctagatagtt ataatgcgca gttggtgcaa ttagaagcta tgctaagaaa taaggaatta     3840

aaacttcagg aaagtgagaa ggagaaggag tgcctgcagc atgaattaca gacaattaga     3900

ggagatcttg aaaccagcaa tttgcaagac atgcagtcac aagaaattag tggccttaaa     3960

gactgtgaaa tagatgcgga agaaaagtat atttcagggc ctcatgagtt gtcaacaagt     4020

caaaacgaca atgcacacct tcagtgctct ctgcaaacaa caatgaacaa gctgaatgag     4080

ctagagaaaa tatgtgaaat actgcaggct gaaaagtatg aactcgtaac tgagctgaat     4140

gattcaaggt cagaatgtat cacagcaact aggaaaatgg cagaagaggt agggaaacta     4200

ctaaatgaag ttaaaatatt aaatgatgac agtggtcttc tccatggtga gttagtggaa     4260

gacataccag gaggtgaatt tggtgaacaa ccaaatgaac agcaccctgt gtctttggct     4320

ccattggacg agagtaattc ctacgagcac ttgacattgt cagacaaaga agttcaaatg     4380

cactttgccg aattgcaaga gaaattctta tctttacaaa gtgaacacaa aattttacat     4440

gatcagcact gtcagatgag ctctaaaatg tcagagctgc agacctatgt tgactcatta     4500

aaggccgaaa atttggtctt gtcaacgaat ctgagaaact ttcaaggtga cttggtgaag     4560

gagatgcagc tgggcttgga ggaggggctc gttccatccc tgtcatcctc ttgtgtgcct     4620

gacagctcta gtcttagcag tttgggagac tcctcctttt acagagctct tttagaacag     4680

acaggagata tgtctctttt gagtaattta gaaggggctg tttcagcaaa ccagtgcagt     4740

gtagatgaag tattttgcag cagtctgcag gaggagaatc tgaccaggaa agaaacccct     4800

tcggccccag cgaagggtgt tgaagagctt gagtccctct gtgaggtgta ccggcagtcc     4860

ctcgagaagc tagaagagaa aatggaaagt caagggatta tgaaaaataa ggaaattcaa     4920

gagctcgagc agttattaag ttctgaaagg caagagcttg actgccttag gaagcagtat     4980

ttgtcagaaa atgaacagtg gcaacagaag ctgacaagcg tgactctgga gatggagtcc     5040

aagttggcgg cagaaaagaa acagacggaa caactgtcac ttgagctgga agtagcacga     5100

ctccagctac aaggtctgga cttaagttct cggtctttgc ttggcatcga cacagaagat     5160

gctattcaag gccgaaatga gagctgtgac atatcaaaag aacatacttc agaaactaca     5220

gaaagaacac caaagcatga tgttcatcag atttgtgata aagatgctca gcaggacctc     5280

aatctagaca ttgagaaaat aactgagact ggtgcagtga aacccacagg agagtgctct     5340

ggggaacagt ccccagatac caattatgag cctccagggg aagataaaac ccagggctct     5400

tcagaatgca tttctgaatt gtcattttct ggtcctaatg ctttggtacc tatggatttc     5460

ctggggaatc aggaagatat ccataatctt caactgcggg taaaagagac atcaaatgag     5520

aatttgagat tacttcatgt gatagaggac cgtgacagaa aagttgaaag tttgctaaat     5580

gaaatgaaag aattagactc aaaactccat ttacaggagg tacaactaat gaccaaaatt     5640

gaagcatgca tagaattgga aaaaatagtt ggggaactta agaaagaaaa ctcagattta     5700

agtgaaaaat tggaatattt ttcttgtgat caccaggagt tactccagag agtagaaact     5760

tctgaaggcc tcaattctga tttagaaatg catgcagata aatcatcacg tgaagatatt     5820

ggagataatg tggccaaggt gaatgacagc tggaaggaga gatttcttga tgtggaaaat     5880

gagctgagta ggatcagatc ggagaaagct agcattgagc atgaagccct ctacctggag     5940

gctgacttag aggtagttca aacagagaag ctatgtttag aaaaagacaa tgaaaataag     6000

cagaaggtta ttgtctgcct tgaagaagaa ctctcagtgg tcacaagtga gagaaaccag     6060

cttcgtggag aattagatac tatgtcaaaa aaaaccacgg cactggatca gttgtctgaa     6120

aaaatgaagg agaaaacaca agagcttgag tctcatcaaa gtgagtgtct ccattgcatt     6180

caggtggcag aggcagaggt gaaggaaaag acggaactcc ttcagacttt gtcctctgat     6240

gtgagtgagc tgttaaaaga caaaactcat ctccaggaaa agctgcagag tttggaaaag     6300

gactcacagg cactgtcttt gacaaaatgt gagctggaaa accaaattgc acaactgaat     6360

aaagagaaag aattgcttgt caaggaatct gaaagcctgc aggccagact gagtgaatca     6420

gattatgaaa agctgaatgt ctccaaggcc ttggaggccg cactggtgga gaaaggtgag     6480

ttcgcattga ggctgagctc aacacaggag gaagtgcatc agctgagaag aggcatcgag     6540

aaactgagag ttcgcattga ggccgatgaa aagaagcagc tgcacatcgc agagaaactg     6600

aaagaacgcg agcgggagaa tgattcactt aaggataaag ttgagaacct tgaaagggaa     6660

ttgcagatgt cagaagaaaa ccaggagcta gtgattcttg atgccgagaa ttccaaagca     6720

gaagtagaga ctctaaaaac acaaatagaa gagatggcca gaagcctgaa agtttttgaa     6780

ttagaccttg tcacgttaag gtctgaaaaa gaaaatctga caaaacaaat acaagaaaaa     6840

caaggtcagt tgtcagaact agacaagtta ctctcttcat ttaaaagtct gttagaagaa     6900

aaggagcaag cagagataca gatcaaagaa gaatctaaaa ctgcagtgga gatgcttcag     6960

aatcagttaa aggagctaaa tgaggcagta gcagccttgt gtggtgacca agaaattatg     7020

aaggccacag aacagagtct agacccacca atagaggaag agcatcagct gagaaatagc     7080

attgaaaagc tgagagcccg cctagaagct gatgaaaaga agcagctctg tgtcttacaa     7140

caactgaagg aaagtgagca tcatgcagat ttacttaagg gtagagtgga gaaccttgaa     7200

agagagctag agatagccag gacaaaccaa gagcatgcag ctcttgaggc agagaattcc     7260

aaaggagagg tagagaccct aaaagcaaaa atagaaggga tgacccaaag tctgagaggt     7320

ctggaattag atgttgttac tataaggtca gaaaaagaaa atctgacaaa tgaattacaa     7380

aaagagcaag agcgaatatc tgaattagaa ataataaatt catcatttga aaatattttg     7440

caagaaaaag agcaagagaa agtacagatg aaagaaaaat caagcactgc catggagatg     7500

cttcaaacac aattaaaaga gctcaatgag agagtggcag ccctgcataa tgaccaagaa     7560

gcctgtaagg ccaaagagca gaatcttagt agtcaagtag agtgtcttga acttgagaag     7620

gctcagttgc tacaaggcct tgatgaggcc aaaaataatt atattgtttt gcaatcttca     7680

gtgaatggcc tcattcaaga agtagaagat ggcaagcaga aactggagaa gaaggatgaa     7740

gaaatcagta gactgaaaaa tcaaattcaa gaccaagagc agcttgtctc taaactgtcc     7800

caggtggaag gagagcacca actttggaag gagcaaaact tagaactgag aaatctgaca     7860

gtggaattgg agcagaagat ccaagtgcta caatccaaaa atgcctcttt gcaggacaca     7920

ttagaagtgc tgcagagttc ttacaagaat ctagagaatg agcttgaatt gacaaaaatg     7980

gacaaaatgt cctttgttga aaaagtaaac aaaatgactg caaaggaaac tgagctgcag     8040

agggaaatgc atgagatggc acagaaaaca gcagagctgc aagaagaact cagtggagag     8100

aaaaataggc tagctggaga gttgcagtta ctgttggaag aaataaagag cagcaaagat     8160

caattgaagg agctcacact agaaaatagt gaattgaaga agagcctaga ttgcatgcac     8220

aaagaccagg tggaaaagga agggaaagtg agagaggaaa tagctgaata tcagctacgg     8280

cttcatgaag ctgaaaagaa acaccaggct ttgcttttgg acacaaacaa acagtatgaa     8340

gtagaaatcc agacataccg agagaaattg acttctaaag aagaatgtct cagttcacag     8400

aagctggaga tagacctttt aaagtctagt aaagaagagc tcaataattc attgaaagct     8460

actactcaga ttttggaaga attgaagaaa accaagatgg acaatctaaa atatgtaaat     8520

cagttgaaga aggaaaatga acgtgcccag gggaaaatga agttgttgat caaatcctgt     8580

aaacagctgg aagaggaaaa ggagatactg cagaaagaac tctctcaact tcaagctgca     8640

caggagaagc agaaaacagg tactgttatg gataccaagg tcgatgaatt aacaactgag     8700

atcaaagaac tgaaagaaac tcttgaagaa aaaaccaagg aggcagatga atacttggat     8760

aagtactgtt ccttgcttat aagccatgaa aagttagaga aagctaaaga gatgttagag     8820

acacaagtgg cccatctgtg ttcacagcaa tctaaacaag attcccgagg gtctcctttg     8880

ctaggtccag ttgttccagg accatctcca atcccttctg ttactgaaaa gaggttatca     8940

tctggccaaa ataaagcttc aggcaagagg caaagatcca gtggaatatg ggagaatggt     9000

agaggaccaa cacctgctac cccagagagc ttttctaaaa aaagcaagaa agcagtcatg     9060

agtggtattc accctgcaga agacacggaa ggtactgagt ttgagccaga gggacttcca     9120

gaagttgtaa agaaagggtt tgctgacatc ccgacaggaa agactagccc atatatcctg     9180

cgaagaacaa ccatggcaac tcggaccagc ccccgcctgg ctgcacagaa gttagcgcta     9240

tccccactga gtctcggcaa agaaaatctt gcagagtcct ccaaaccaac agctggtggc     9300

agcagatcac aaaaggtcaa agttgctcag cggagcccag tagattcagg caccatcctc     9360

cgagaaccca ccacgaaatc cgtcccagtc aataatcttc ctgagagaag tccgactgac     9420

agccccagag agggcctgag ggtcaagcga ggccgacttg tccccagccc caaagctgga     9480

ctggagtcca acggcagtga gaactgtaag gtccagtgaa ggcactttgt gtgtcagtac     9540

ccctgggagg tgccagtcat tgaatagata aggctgtgcc tacaggactt ctctttagtc     9600

agggcatgct ttattagtga ggagaaaaca attccttaga agtcttaaat atattgtact     9660

ctttagatct cccatgtgta ggtattgaaa aagtttggaa gcactgatca cctgttagca     9720

ttgccattcc tctactgcaa tgtaaatagt ataaagctat gtatataaag ctttttggta     9780

atatgttaca attaaaatga caagcactat atcacaatct ctgtttgtat gtgggtttta     9840

cactaaaaaa atgcaaaaca cattttattc ttctaattaa cagctcctag gaaaatgtag     9900

acttttgctt tatgatattc tatctgtagt atgaggcatg gaatagtttt gtatcgggaa     9960

tttctcagag ctgagtaaaa tgaaggaaaa gcatgttatg tgtttttaag gaaaatgtgc    10020

acacatatac atgtaggagt gtttatcttt ctcttacaat ctgttttaga catctttgct    10080

tatgaaacct gtacatatgt gtgtgtgggt atgtgtttat ttccagtgag ggctgcaggc    10140

ttcctagagg tgtgctatac catgcgtctg tcgttgtgct tttttctgtt tttagaccaa    10200

ttttttacag ttctttggta agcattgtcg tatctggtga tggattaaca tatagccttt    10260

gttttctaat aaaatagtcg ccttcgtttt ctgtaaaaaa aaaaaaaaaa aaaaaa        10316


<210>  54
<211>  3114
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human centromere protein F

<400>  54

Met Ser Trp Ala Leu Glu Glu Trp Lys Glu Gly Leu Pro Thr Arg Ala 
1               5                   10                  15      


Leu Gln Lys Ile Gln Glu Leu Glu Gly Gln Leu Asp Lys Leu Lys Lys 
            20                  25                  30          


Glu Lys Gln Gln Arg Gln Phe Gln Leu Asp Ser Leu Glu Ala Ala Leu 
        35                  40                  45              


Gln Lys Gln Lys Gln Lys Val Glu Asn Glu Lys Thr Glu Gly Thr Asn 
    50                  55                  60                  


Leu Lys Arg Glu Asn Gln Arg Leu Met Glu Ile Cys Glu Ser Leu Glu 
65                  70                  75                  80  


Lys Thr Lys Gln Lys Ile Ser His Glu Leu Gln Val Lys Glu Ser Gln 
                85                  90                  95      


Val Asn Phe Gln Glu Gly Gln Leu Asn Ser Gly Lys Lys Gln Ile Glu 
            100                 105                 110         


Lys Leu Glu Gln Glu Leu Lys Arg Cys Lys Ser Glu Leu Glu Arg Ser 
        115                 120                 125             


Gln Gln Ala Ala Gln Ser Ala Asp Val Ser Leu Asn Pro Cys Asn Thr 
    130                 135                 140                 


Pro Gln Lys Ile Phe Thr Thr Pro Leu Thr Pro Ser Gln Tyr Tyr Ser 
145                 150                 155                 160 


Gly Ser Lys Tyr Glu Asp Leu Lys Glu Lys Tyr Asn Lys Glu Val Glu 
                165                 170                 175     


Glu Arg Lys Arg Leu Glu Ala Glu Val Lys Ala Leu Gln Ala Lys Lys 
            180                 185                 190         


Ala Ser Gln Thr Leu Pro Gln Ala Thr Met Asn His Arg Asp Ile Ala 
        195                 200                 205             


Arg His Gln Ala Ser Ser Ser Val Phe Ser Trp Gln Gln Glu Lys Thr 
    210                 215                 220                 


Pro Ser His Leu Ser Ser Asn Ser Gln Arg Thr Pro Ile Arg Arg Asp 
225                 230                 235                 240 


Phe Ser Ala Ser Tyr Phe Ser Gly Glu Gln Glu Val Thr Pro Ser Arg 
                245                 250                 255     


Ser Thr Leu Gln Ile Gly Lys Arg Asp Ala Asn Ser Ser Phe Phe Asp 
            260                 265                 270         


Asn Ser Ser Ser Pro His Leu Leu Asp Gln Leu Lys Ala Gln Asn Gln 
        275                 280                 285             


Glu Leu Arg Asn Lys Ile Asn Glu Leu Glu Leu Arg Leu Gln Gly His 
    290                 295                 300                 


Glu Lys Glu Met Lys Gly Gln Val Asn Lys Phe Gln Glu Leu Gln Leu 
305                 310                 315                 320 


Gln Leu Glu Lys Ala Lys Val Glu Leu Ile Glu Lys Glu Lys Val Leu 
                325                 330                 335     


Asn Lys Cys Arg Asp Glu Leu Val Arg Thr Thr Ala Gln Tyr Asp Gln 
            340                 345                 350         


Ala Ser Thr Lys Tyr Thr Ala Leu Glu Gln Lys Leu Lys Lys Leu Thr 
        355                 360                 365             


Glu Asp Leu Ser Cys Gln Arg Gln Asn Ala Glu Ser Ala Arg Cys Ser 
    370                 375                 380                 


Leu Glu Gln Lys Ile Lys Glu Lys Glu Lys Glu Phe Gln Glu Glu Leu 
385                 390                 395                 400 


Ser Arg Gln Gln Arg Ser Phe Gln Thr Leu Asp Gln Glu Cys Ile Gln 
                405                 410                 415     


Met Lys Ala Arg Leu Thr Gln Glu Leu Gln Gln Ala Lys Asn Met His 
            420                 425                 430         


Asn Val Leu Gln Ala Glu Leu Asp Lys Leu Thr Ser Val Lys Gln Gln 
        435                 440                 445             


Leu Glu Asn Asn Leu Glu Glu Phe Lys Gln Lys Leu Cys Arg Ala Glu 
    450                 455                 460                 


Gln Ala Phe Gln Ala Ser Gln Ile Lys Glu Asn Glu Leu Arg Arg Ser 
465                 470                 475                 480 


Met Glu Glu Met Lys Lys Glu Asn Asn Leu Leu Lys Ser His Ser Glu 
                485                 490                 495     


Gln Lys Ala Arg Glu Val Cys His Leu Glu Ala Glu Leu Lys Asn Ile 
            500                 505                 510         


Lys Gln Cys Leu Asn Gln Ser Gln Asn Phe Ala Glu Glu Met Lys Ala 
        515                 520                 525             


Lys Asn Thr Ser Gln Glu Thr Met Leu Arg Asp Leu Gln Glu Lys Ile 
    530                 535                 540                 


Asn Gln Gln Glu Asn Ser Leu Thr Leu Glu Lys Leu Lys Leu Ala Val 
545                 550                 555                 560 


Ala Asp Leu Glu Lys Gln Arg Asp Cys Ser Gln Asp Leu Leu Lys Lys 
                565                 570                 575     


Arg Glu His His Ile Glu Gln Leu Asn Asp Lys Leu Ser Lys Thr Glu 
            580                 585                 590         


Lys Glu Ser Lys Ala Leu Leu Ser Ala Leu Glu Leu Lys Lys Lys Glu 
        595                 600                 605             


Tyr Glu Glu Leu Lys Glu Glu Lys Thr Leu Phe Ser Cys Trp Lys Ser 
    610                 615                 620                 


Glu Asn Glu Lys Leu Leu Thr Gln Met Glu Ser Glu Lys Glu Asn Leu 
625                 630                 635                 640 


Gln Ser Lys Ile Asn His Leu Glu Thr Cys Leu Lys Thr Gln Gln Ile 
                645                 650                 655     


Lys Ser His Glu Tyr Asn Glu Arg Val Arg Thr Leu Glu Met Asp Arg 
            660                 665                 670         


Glu Asn Leu Ser Val Glu Ile Arg Asn Leu His Asn Val Leu Asp Ser 
        675                 680                 685             


Lys Ser Val Glu Val Glu Thr Gln Lys Leu Ala Tyr Met Glu Leu Gln 
    690                 695                 700                 


Gln Lys Ala Glu Phe Ser Asp Gln Lys His Gln Lys Glu Ile Glu Asn 
705                 710                 715                 720 


Met Cys Leu Lys Thr Ser Gln Leu Thr Gly Gln Val Glu Asp Leu Glu 
                725                 730                 735     


His Lys Leu Gln Leu Leu Ser Asn Glu Ile Met Asp Lys Asp Arg Cys 
            740                 745                 750         


Tyr Gln Asp Leu His Ala Glu Tyr Glu Ser Leu Arg Asp Leu Leu Lys 
        755                 760                 765             


Ser Lys Asp Ala Ser Leu Val Thr Asn Glu Asp His Gln Arg Ser Leu 
    770                 775                 780                 


Leu Ala Phe Asp Gln Gln Pro Ala Met His His Ser Phe Ala Asn Ile 
785                 790                 795                 800 


Ile Gly Glu Gln Gly Ser Met Pro Ser Glu Arg Ser Glu Cys Arg Leu 
                805                 810                 815     


Glu Ala Asp Gln Ser Pro Lys Asn Ser Ala Ile Leu Gln Asn Arg Val 
            820                 825                 830         


Asp Ser Leu Glu Phe Ser Leu Glu Ser Gln Lys Gln Met Asn Ser Asp 
        835                 840                 845             


Leu Gln Lys Gln Cys Glu Glu Leu Val Gln Ile Lys Gly Glu Ile Glu 
    850                 855                 860                 


Glu Asn Leu Met Lys Ala Glu Gln Met His Gln Ser Phe Val Ala Glu 
865                 870                 875                 880 


Thr Ser Gln Arg Ile Ser Lys Leu Gln Glu Asp Thr Ser Ala His Gln 
                885                 890                 895     


Asn Val Val Ala Glu Thr Leu Ser Ala Leu Glu Asn Lys Glu Lys Glu 
            900                 905                 910         


Leu Gln Leu Leu Asn Asp Lys Val Glu Thr Glu Gln Ala Glu Ile Gln 
        915                 920                 925             


Glu Leu Lys Lys Ser Asn His Leu Leu Glu Asp Ser Leu Lys Glu Leu 
    930                 935                 940                 


Gln Leu Leu Ser Glu Thr Leu Ser Leu Glu Lys Lys Glu Met Ser Ser 
945                 950                 955                 960 


Ile Ile Ser Leu Asn Lys Arg Glu Ile Glu Glu Leu Thr Gln Glu Asn 
                965                 970                 975     


Gly Thr Leu Lys Glu Ile Asn Ala Ser Leu Asn Gln Glu Lys Met Asn 
            980                 985                 990         


Leu Ile Gln Lys Ser Glu Ser Phe  Ala Asn Tyr Ile Asp  Glu Arg Glu 
        995                 1000                 1005             


Lys Ser  Ile Ser Glu Leu Ser  Asp Gln Tyr Lys Gln  Glu Lys Leu 
    1010                 1015                 1020             


Ile Leu  Leu Gln Arg Cys Glu  Glu Thr Gly Asn Ala  Tyr Glu Asp 
    1025                 1030                 1035             


Leu Ser  Gln Lys Tyr Lys Ala  Ala Gln Glu Lys Asn  Ser Lys Leu 
    1040                 1045                 1050             


Glu Cys  Leu Leu Asn Glu Cys  Thr Ser Leu Cys Glu  Asn Arg Lys 
    1055                 1060                 1065             


Asn Glu  Leu Glu Gln Leu Lys  Glu Ala Phe Ala Lys  Glu His Gln 
    1070                 1075                 1080             


Glu Phe  Leu Thr Lys Leu Ala  Phe Ala Glu Glu Arg  Asn Gln Asn 
    1085                 1090                 1095             


Leu Met  Leu Glu Leu Glu Thr  Val Gln Gln Ala Leu  Arg Ser Glu 
    1100                 1105                 1110             


Met Thr  Asp Asn Gln Asn Asn  Ser Lys Ser Glu Ala  Gly Gly Leu 
    1115                 1120                 1125             


Lys Gln  Glu Ile Met Thr Leu  Lys Glu Glu Gln Asn  Lys Met Gln 
    1130                 1135                 1140             


Lys Glu  Val Asn Asp Leu Leu  Gln Glu Asn Glu Gln  Leu Met Lys 
    1145                 1150                 1155             


Val Met  Lys Thr Lys His Glu  Cys Gln Asn Leu Glu  Ser Glu Pro 
    1160                 1165                 1170             


Ile Arg  Asn Ser Val Lys Glu  Arg Glu Ser Glu Arg  Asn Gln Cys 
    1175                 1180                 1185             


Asn Phe  Lys Pro Gln Met Asp  Leu Glu Val Lys Glu  Ile Ser Leu 
    1190                 1195                 1200             


Asp Ser  Tyr Asn Ala Gln Leu  Val Gln Leu Glu Ala  Met Leu Arg 
    1205                 1210                 1215             


Asn Lys  Glu Leu Lys Leu Gln  Glu Ser Glu Lys Glu  Lys Glu Cys 
    1220                 1225                 1230             


Leu Gln  His Glu Leu Gln Thr  Ile Arg Gly Asp Leu  Glu Thr Ser 
    1235                 1240                 1245             


Asn Leu  Gln Asp Met Gln Ser  Gln Glu Ile Ser Gly  Leu Lys Asp 
    1250                 1255                 1260             


Cys Glu  Ile Asp Ala Glu Glu  Lys Tyr Ile Ser Gly  Pro His Glu 
    1265                 1270                 1275             


Leu Ser  Thr Ser Gln Asn Asp  Asn Ala His Leu Gln  Cys Ser Leu 
    1280                 1285                 1290             


Gln Thr  Thr Met Asn Lys Leu  Asn Glu Leu Glu Lys  Ile Cys Glu 
    1295                 1300                 1305             


Ile Leu  Gln Ala Glu Lys Tyr  Glu Leu Val Thr Glu  Leu Asn Asp 
    1310                 1315                 1320             


Ser Arg  Ser Glu Cys Ile Thr  Ala Thr Arg Lys Met  Ala Glu Glu 
    1325                 1330                 1335             


Val Gly  Lys Leu Leu Asn Glu  Val Lys Ile Leu Asn  Asp Asp Ser 
    1340                 1345                 1350             


Gly Leu  Leu His Gly Glu Leu  Val Glu Asp Ile Pro  Gly Gly Glu 
    1355                 1360                 1365             


Phe Gly  Glu Gln Pro Asn Glu  Gln His Pro Val Ser  Leu Ala Pro 
    1370                 1375                 1380             


Leu Asp  Glu Ser Asn Ser Tyr  Glu His Leu Thr Leu  Ser Asp Lys 
    1385                 1390                 1395             


Glu Val  Gln Met His Phe Ala  Glu Leu Gln Glu Lys  Phe Leu Ser 
    1400                 1405                 1410             


Leu Gln  Ser Glu His Lys Ile  Leu His Asp Gln His  Cys Gln Met 
    1415                 1420                 1425             


Ser Ser  Lys Met Ser Glu Leu  Gln Thr Tyr Val Asp  Ser Leu Lys 
    1430                 1435                 1440             


Ala Glu  Asn Leu Val Leu Ser  Thr Asn Leu Arg Asn  Phe Gln Gly 
    1445                 1450                 1455             


Asp Leu  Val Lys Glu Met Gln  Leu Gly Leu Glu Glu  Gly Leu Val 
    1460                 1465                 1470             


Pro Ser  Leu Ser Ser Ser Cys  Val Pro Asp Ser Ser  Ser Leu Ser 
    1475                 1480                 1485             


Ser Leu  Gly Asp Ser Ser Phe  Tyr Arg Ala Leu Leu  Glu Gln Thr 
    1490                 1495                 1500             


Gly Asp  Met Ser Leu Leu Ser  Asn Leu Glu Gly Ala  Val Ser Ala 
    1505                 1510                 1515             


Asn Gln  Cys Ser Val Asp Glu  Val Phe Cys Ser Ser  Leu Gln Glu 
    1520                 1525                 1530             


Glu Asn  Leu Thr Arg Lys Glu  Thr Pro Ser Ala Pro  Ala Lys Gly 
    1535                 1540                 1545             


Val Glu  Glu Leu Glu Ser Leu  Cys Glu Val Tyr Arg  Gln Ser Leu 
    1550                 1555                 1560             


Glu Lys  Leu Glu Glu Lys Met  Glu Ser Gln Gly Ile  Met Lys Asn 
    1565                 1570                 1575             


Lys Glu  Ile Gln Glu Leu Glu  Gln Leu Leu Ser Ser  Glu Arg Gln 
    1580                 1585                 1590             


Glu Leu  Asp Cys Leu Arg Lys  Gln Tyr Leu Ser Glu  Asn Glu Gln 
    1595                 1600                 1605             


Trp Gln  Gln Lys Leu Thr Ser  Val Thr Leu Glu Met  Glu Ser Lys 
    1610                 1615                 1620             


Leu Ala  Ala Glu Lys Lys Gln  Thr Glu Gln Leu Ser  Leu Glu Leu 
    1625                 1630                 1635             


Glu Val  Ala Arg Leu Gln Leu  Gln Gly Leu Asp Leu  Ser Ser Arg 
    1640                 1645                 1650             


Ser Leu  Leu Gly Ile Asp Thr  Glu Asp Ala Ile Gln  Gly Arg Asn 
    1655                 1660                 1665             


Glu Ser  Cys Asp Ile Ser Lys  Glu His Thr Ser Glu  Thr Thr Glu 
    1670                 1675                 1680             


Arg Thr  Pro Lys His Asp Val  His Gln Ile Cys Asp  Lys Asp Ala 
    1685                 1690                 1695             


Gln Gln  Asp Leu Asn Leu Asp  Ile Glu Lys Ile Thr  Glu Thr Gly 
    1700                 1705                 1710             


Ala Val  Lys Pro Thr Gly Glu  Cys Ser Gly Glu Gln  Ser Pro Asp 
    1715                 1720                 1725             


Thr Asn  Tyr Glu Pro Pro Gly  Glu Asp Lys Thr Gln  Gly Ser Ser 
    1730                 1735                 1740             


Glu Cys  Ile Ser Glu Leu Ser  Phe Ser Gly Pro Asn  Ala Leu Val 
    1745                 1750                 1755             


Pro Met  Asp Phe Leu Gly Asn  Gln Glu Asp Ile His  Asn Leu Gln 
    1760                 1765                 1770             


Leu Arg  Val Lys Glu Thr Ser  Asn Glu Asn Leu Arg  Leu Leu His 
    1775                 1780                 1785             


Val Ile  Glu Asp Arg Asp Arg  Lys Val Glu Ser Leu  Leu Asn Glu 
    1790                 1795                 1800             


Met Lys  Glu Leu Asp Ser Lys  Leu His Leu Gln Glu  Val Gln Leu 
    1805                 1810                 1815             


Met Thr  Lys Ile Glu Ala Cys  Ile Glu Leu Glu Lys  Ile Val Gly 
    1820                 1825                 1830             


Glu Leu  Lys Lys Glu Asn Ser  Asp Leu Ser Glu Lys  Leu Glu Tyr 
    1835                 1840                 1845             


Phe Ser  Cys Asp His Gln Glu  Leu Leu Gln Arg Val  Glu Thr Ser 
    1850                 1855                 1860             


Glu Gly  Leu Asn Ser Asp Leu  Glu Met His Ala Asp  Lys Ser Ser 
    1865                 1870                 1875             


Arg Glu  Asp Ile Gly Asp Asn  Val Ala Lys Val Asn  Asp Ser Trp 
    1880                 1885                 1890             


Lys Glu  Arg Phe Leu Asp Val  Glu Asn Glu Leu Ser  Arg Ile Arg 
    1895                 1900                 1905             


Ser Glu  Lys Ala Ser Ile Glu  His Glu Ala Leu Tyr  Leu Glu Ala 
    1910                 1915                 1920             


Asp Leu  Glu Val Val Gln Thr  Glu Lys Leu Cys Leu  Glu Lys Asp 
    1925                 1930                 1935             


Asn Glu  Asn Lys Gln Lys Val  Ile Val Cys Leu Glu  Glu Glu Leu 
    1940                 1945                 1950             


Ser Val  Val Thr Ser Glu Arg  Asn Gln Leu Arg Gly  Glu Leu Asp 
    1955                 1960                 1965             


Thr Met  Ser Lys Lys Thr Thr  Ala Leu Asp Gln Leu  Ser Glu Lys 
    1970                 1975                 1980             


Met Lys  Glu Lys Thr Gln Glu  Leu Glu Ser His Gln  Ser Glu Cys 
    1985                 1990                 1995             


Leu His  Cys Ile Gln Val Ala  Glu Ala Glu Val Lys  Glu Lys Thr 
    2000                 2005                 2010             


Glu Leu  Leu Gln Thr Leu Ser  Ser Asp Val Ser Glu  Leu Leu Lys 
    2015                 2020                 2025             


Asp Lys  Thr His Leu Gln Glu  Lys Leu Gln Ser Leu  Glu Lys Asp 
    2030                 2035                 2040             


Ser Gln  Ala Leu Ser Leu Thr  Lys Cys Glu Leu Glu  Asn Gln Ile 
    2045                 2050                 2055             


Ala Gln  Leu Asn Lys Glu Lys  Glu Leu Leu Val Lys  Glu Ser Glu 
    2060                 2065                 2070             


Ser Leu  Gln Ala Arg Leu Ser  Glu Ser Asp Tyr Glu  Lys Leu Asn 
    2075                 2080                 2085             


Val Ser  Lys Ala Leu Glu Ala  Ala Leu Val Glu Lys  Gly Glu Phe 
    2090                 2095                 2100             


Ala Leu  Arg Leu Ser Ser Thr  Gln Glu Glu Val His  Gln Leu Arg 
    2105                 2110                 2115             


Arg Gly  Ile Glu Lys Leu Arg  Val Arg Ile Glu Ala  Asp Glu Lys 
    2120                 2125                 2130             


Lys Gln  Leu His Ile Ala Glu  Lys Leu Lys Glu Arg  Glu Arg Glu 
    2135                 2140                 2145             


Asn Asp  Ser Leu Lys Asp Lys  Val Glu Asn Leu Glu  Arg Glu Leu 
    2150                 2155                 2160             


Gln Met  Ser Glu Glu Asn Gln  Glu Leu Val Ile Leu  Asp Ala Glu 
    2165                 2170                 2175             


Asn Ser  Lys Ala Glu Val Glu  Thr Leu Lys Thr Gln  Ile Glu Glu 
    2180                 2185                 2190             


Met Ala  Arg Ser Leu Lys Val  Phe Glu Leu Asp Leu  Val Thr Leu 
    2195                 2200                 2205             


Arg Ser  Glu Lys Glu Asn Leu  Thr Lys Gln Ile Gln  Glu Lys Gln 
    2210                 2215                 2220             


Gly Gln  Leu Ser Glu Leu Asp  Lys Leu Leu Ser Ser  Phe Lys Ser 
    2225                 2230                 2235             


Leu Leu  Glu Glu Lys Glu Gln  Ala Glu Ile Gln Ile  Lys Glu Glu 
    2240                 2245                 2250             


Ser Lys  Thr Ala Val Glu Met  Leu Gln Asn Gln Leu  Lys Glu Leu 
    2255                 2260                 2265             


Asn Glu  Ala Val Ala Ala Leu  Cys Gly Asp Gln Glu  Ile Met Lys 
    2270                 2275                 2280             


Ala Thr  Glu Gln Ser Leu Asp  Pro Pro Ile Glu Glu  Glu His Gln 
    2285                 2290                 2295             


Leu Arg  Asn Ser Ile Glu Lys  Leu Arg Ala Arg Leu  Glu Ala Asp 
    2300                 2305                 2310             


Glu Lys  Lys Gln Leu Cys Val  Leu Gln Gln Leu Lys  Glu Ser Glu 
    2315                 2320                 2325             


His His  Ala Asp Leu Leu Lys  Gly Arg Val Glu Asn  Leu Glu Arg 
    2330                 2335                 2340             


Glu Leu  Glu Ile Ala Arg Thr  Asn Gln Glu His Ala  Ala Leu Glu 
    2345                 2350                 2355             


Ala Glu  Asn Ser Lys Gly Glu  Val Glu Thr Leu Lys  Ala Lys Ile 
    2360                 2365                 2370             


Glu Gly  Met Thr Gln Ser Leu  Arg Gly Leu Glu Leu  Asp Val Val 
    2375                 2380                 2385             


Thr Ile  Arg Ser Glu Lys Glu  Asn Leu Thr Asn Glu  Leu Gln Lys 
    2390                 2395                 2400             


Glu Gln  Glu Arg Ile Ser Glu  Leu Glu Ile Ile Asn  Ser Ser Phe 
    2405                 2410                 2415             


Glu Asn  Ile Leu Gln Glu Lys  Glu Gln Glu Lys Val  Gln Met Lys 
    2420                 2425                 2430             


Glu Lys  Ser Ser Thr Ala Met  Glu Met Leu Gln Thr  Gln Leu Lys 
    2435                 2440                 2445             


Glu Leu  Asn Glu Arg Val Ala  Ala Leu His Asn Asp  Gln Glu Ala 
    2450                 2455                 2460             


Cys Lys  Ala Lys Glu Gln Asn  Leu Ser Ser Gln Val  Glu Cys Leu 
    2465                 2470                 2475             


Glu Leu  Glu Lys Ala Gln Leu  Leu Gln Gly Leu Asp  Glu Ala Lys 
    2480                 2485                 2490             


Asn Asn  Tyr Ile Val Leu Gln  Ser Ser Val Asn Gly  Leu Ile Gln 
    2495                 2500                 2505             


Glu Val  Glu Asp Gly Lys Gln  Lys Leu Glu Lys Lys  Asp Glu Glu 
    2510                 2515                 2520             


Ile Ser  Arg Leu Lys Asn Gln  Ile Gln Asp Gln Glu  Gln Leu Val 
    2525                 2530                 2535             


Ser Lys  Leu Ser Gln Val Glu  Gly Glu His Gln Leu  Trp Lys Glu 
    2540                 2545                 2550             


Gln Asn  Leu Glu Leu Arg Asn  Leu Thr Val Glu Leu  Glu Gln Lys 
    2555                 2560                 2565             


Ile Gln  Val Leu Gln Ser Lys  Asn Ala Ser Leu Gln  Asp Thr Leu 
    2570                 2575                 2580             


Glu Val  Leu Gln Ser Ser Tyr  Lys Asn Leu Glu Asn  Glu Leu Glu 
    2585                 2590                 2595             


Leu Thr  Lys Met Asp Lys Met  Ser Phe Val Glu Lys  Val Asn Lys 
    2600                 2605                 2610             


Met Thr  Ala Lys Glu Thr Glu  Leu Gln Arg Glu Met  His Glu Met 
    2615                 2620                 2625             


Ala Gln  Lys Thr Ala Glu Leu  Gln Glu Glu Leu Ser  Gly Glu Lys 
    2630                 2635                 2640             


Asn Arg  Leu Ala Gly Glu Leu  Gln Leu Leu Leu Glu  Glu Ile Lys 
    2645                 2650                 2655             


Ser Ser  Lys Asp Gln Leu Lys  Glu Leu Thr Leu Glu  Asn Ser Glu 
    2660                 2665                 2670             


Leu Lys  Lys Ser Leu Asp Cys  Met His Lys Asp Gln  Val Glu Lys 
    2675                 2680                 2685             


Glu Gly  Lys Val Arg Glu Glu  Ile Ala Glu Tyr Gln  Leu Arg Leu 
    2690                 2695                 2700             


His Glu  Ala Glu Lys Lys His  Gln Ala Leu Leu Leu  Asp Thr Asn 
    2705                 2710                 2715             


Lys Gln  Tyr Glu Val Glu Ile  Gln Thr Tyr Arg Glu  Lys Leu Thr 
    2720                 2725                 2730             


Ser Lys  Glu Glu Cys Leu Ser  Ser Gln Lys Leu Glu  Ile Asp Leu 
    2735                 2740                 2745             


Leu Lys  Ser Ser Lys Glu Glu  Leu Asn Asn Ser Leu  Lys Ala Thr 
    2750                 2755                 2760             


Thr Gln  Ile Leu Glu Glu Leu  Lys Lys Thr Lys Met  Asp Asn Leu 
    2765                 2770                 2775             


Lys Tyr  Val Asn Gln Leu Lys  Lys Glu Asn Glu Arg  Ala Gln Gly 
    2780                 2785                 2790             


Lys Met  Lys Leu Leu Ile Lys  Ser Cys Lys Gln Leu  Glu Glu Glu 
    2795                 2800                 2805             


Lys Glu  Ile Leu Gln Lys Glu  Leu Ser Gln Leu Gln  Ala Ala Gln 
    2810                 2815                 2820             


Glu Lys  Gln Lys Thr Gly Thr  Val Met Asp Thr Lys  Val Asp Glu 
    2825                 2830                 2835             


Leu Thr  Thr Glu Ile Lys Glu  Leu Lys Glu Thr Leu  Glu Glu Lys 
    2840                 2845                 2850             


Thr Lys  Glu Ala Asp Glu Tyr  Leu Asp Lys Tyr Cys  Ser Leu Leu 
    2855                 2860                 2865             


Ile Ser  His Glu Lys Leu Glu  Lys Ala Lys Glu Met  Leu Glu Thr 
    2870                 2875                 2880             


Gln Val  Ala His Leu Cys Ser  Gln Gln Ser Lys Gln  Asp Ser Arg 
    2885                 2890                 2895             


Gly Ser  Pro Leu Leu Gly Pro  Val Val Pro Gly Pro  Ser Pro Ile 
    2900                 2905                 2910             


Pro Ser  Val Thr Glu Lys Arg  Leu Ser Ser Gly Gln  Asn Lys Ala 
    2915                 2920                 2925             


Ser Gly  Lys Arg Gln Arg Ser  Ser Gly Ile Trp Glu  Asn Gly Arg 
    2930                 2935                 2940             


Gly Pro  Thr Pro Ala Thr Pro  Glu Ser Phe Ser Lys  Lys Ser Lys 
    2945                 2950                 2955             


Lys Ala  Val Met Ser Gly Ile  His Pro Ala Glu Asp  Thr Glu Gly 
    2960                 2965                 2970             


Thr Glu  Phe Glu Pro Glu Gly  Leu Pro Glu Val Val  Lys Lys Gly 
    2975                 2980                 2985             


Phe Ala  Asp Ile Pro Thr Gly  Lys Thr Ser Pro Tyr  Ile Leu Arg 
    2990                 2995                 3000             


Arg Thr  Thr Met Ala Thr Arg  Thr Ser Pro Arg Leu  Ala Ala Gln 
    3005                 3010                 3015             


Lys Leu  Ala Leu Ser Pro Leu  Ser Leu Gly Lys Glu  Asn Leu Ala 
    3020                 3025                 3030             


Glu Ser  Ser Lys Pro Thr Ala  Gly Gly Ser Arg Ser  Gln Lys Val 
    3035                 3040                 3045             


Lys Val  Ala Gln Arg Ser Pro  Val Asp Ser Gly Thr  Ile Leu Arg 
    3050                 3055                 3060             


Glu Pro  Thr Thr Lys Ser Val  Pro Val Asn Asn Leu  Pro Glu Arg 
    3065                 3070                 3075             


Ser Pro  Thr Asp Ser Pro Arg  Glu Gly Leu Arg Val  Lys Arg Gly 
    3080                 3085                 3090             


Arg Leu  Val Pro Ser Pro Lys  Ala Gly Leu Glu Ser  Asn Gly Ser 
    3095                 3100                 3105             


Glu Asn  Cys Lys Val Gln 
    3110                 


<210>  55
<211>  11130
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Mouse centromere protein F (Cenpf), mRNA

<400>  55
agtttgaatc gctcgtgctg gtcggggagg aacggtgcgc tgtgtgagga gctcggcggt       60

gaggaactcg gggctcgcag agcccggagc caggttctgt gaggagctca gtttacttct      120

aaatgcttta aaaataaaac aagatgagct gggccctgga agaatggaag gaaggtctcc      180

cctccagagc tcttcagaag atccaagagc ttgaaggaca gctggagaag ctgaagaagg      240

agaaacaaca gaggcagttc cagctggact ctctcgaagc tgcgctgcag aagcagaagc      300

agaaggttga agacggaaag actgagggtg cagacctgaa aagggaaaat caaaggttga      360

tggagatatg cgaacatttg gagaagtcaa ggcagaagct gtctcatgaa cttcaagtta      420

aggagtcaca agtgaatctc caagagagcc aactgagctc atgcaaaaag caaatagaaa      480

aactggaaca ggaacttaag cggtgtaaat ctgaatttga aagaagccaa caagttgcac      540

aatcggcaga tgtttctctg aatccatgca gtacaccaca gaaactcttt gcaactccac      600

tcacaccgag ttccacatac gaagatctga aagaaaaata taataaagaa gttgaagaac      660

ggaagaggtt agaggaagag gttaaagctt tgcatgcaaa aaaagtgagc ctgcctgttt      720

cccaagccac catgaaccac cgggacattg cgagacatca ggcttcctca tcagtgtttc      780

cttggcaaca ggaaaatacc ccaagtcgcc tttcatcgga tgctctgaaa accccactga      840

ggagagacgg ctctgctgct cactttttgg gggaagaagt gagtcctaac aaatcaagta      900

tgaagacagg gagaggagac tgcagcagcc tccctggtga gcctcacagc gctcagcttt      960

tgcaccaggc caaagcccag aatcaagacc taaaaagcaa gatgactgag ttagaactac     1020

gcctgcaagg gcaagaaaag gaaatgagaa gccaagtgaa taaatgtcaa gacttacagc     1080

tacagctgga gaagacgaaa gtggaattga ttgaaaagga gagaattttg aataaaacca     1140

gagatgaagt agtgagaagc acagcacagt atgaccaggc cgcagccaag tgtactacct     1200

tggaacaaaa gctgaaaact ttgactgagg agttgagttg tcaccgacag aacgcagaga     1260

gtgctaaacg ttctctggaa cagaggatta aggagaaaga aaaggagctt caagaggagc     1320

tgtcccgaca gcatcaatct ttccaagctc tggacagtga gtacactcag atgaaaacca     1380

gacttaccca ggagttacag caagtcaagc atttgcacag caccctccag ctggaactgg     1440

agaaggtcac atcagtgaag cagcagttag aaaggaattt ggaagaaatt aggcttaagt     1500

tgagcagagc agaacaagct cttcaggcaa gtcaggtcgc agaaaacgag ctgaggagaa     1560

gcagtgagga aatgaagaag gagaacagtc tcattaggag tcagtctgag cagaggacca     1620

gagaagtctg ccacctggag gaagaacttg gtaaagtcaa agtgtctttg agtaagagcc     1680

agaattttgc agaagaaatg aaggctaaga atacctctca ggaaatcatg ttacgagatc     1740

ttcaggaaaa actaaatcag caagaaaact cactaacttt agagaagctg aaacttgccc     1800

tagctgatct ggaaagacag cgaaactgtt ctcaagatct cttgaagaaa agggaacatc     1860

acattgatca actgaataat aagttaaata agatagagaa agagtttgaa actttgctga     1920

gtgctttgga attaaaaaag aaagaatgtg aagaattgaa agaagagaaa aatcagattt     1980

ctttttggaa aattgatagt gaaaaactca taaatcagat agaatcagaa aaagaaatct     2040

tattgggtaa aattaaccac ttagagacca gcctcaagac acaacaagta agtcctgact     2100

ctaatgagag aataagaaca ctggagatgg aaagagaaaa ctttactgtg gagattaaaa     2160

accttcaaag tatgttagac agcaagatgg tagagatcaa gacacagaaa caagcttact     2220

tggaactgca gcagaaatcc gaatcctcgg accaaaagca tcagaaggag atagagaata     2280

tgtgcttgaa agcaaataag ctcactgggc aagttgaaag tttggaatgt aagcttcagt     2340

tattgtcaag tgaagtagtg accaaagacc agcagtacca agacttgcgt atggaatatg     2400

agacactgag ggatttgctc aagtccagag gatcttctct ggtgacaaat gaggataatc     2460

agcgaagttc tgaggataat cagagaagtt ctgaggataa tcagagaggc tctttggctt     2520

ttgaacagca gcctgcagtg agtgattcct ttgcaaatgt aatggggaga aaaggaagca     2580

taaattcaga aaggagtgac tgctctgtag atgggggccg aagtccagaa catatagcca     2640

tcttacaaaa tagagtcact tcacttgaaa gttccttgga gtctcaaaac cagatgaatt     2700

cagatttgca aatgcggtgt gaagagttgc tacaaatcaa aggggaagta gaagaaaacc     2760

tcagtaaagc agagcagatt catcagaatt ttgtggctga aacaaatcaa tgtattagta     2820

aattgcagga agatgctgca gttcatcaga atattgttgc tgagacttta gcaacccttg     2880

agagtaagga aaaagagtta cagcttttga aagaaaaatt agaagctcag caaacagagg     2940

ttcaaaagtt aaataagaat aactgtcttc ttgaaggtac tctgaaggag ctacagcttt     3000

tatctgacac tctgagctca gagaagaagg aaatgaattc tatcatctca ttaagtaaaa     3060

aaaacattga agagttaacc caagcaaacg aggctctcaa ggaagttaat gaggccttag     3120

agcaggagaa aatgaattta ctccaaaagc atgagaagat tacaagctgt atagcagaac     3180

aagagagaag cattgcagag ctgtctgatc agtacaagca agaaagactt caattattac     3240

aacggtgtga agaaacagaa gctgtgttgg aagatctcag gggaaactac aaaacagcac     3300

aagaaaacaa tgctaagtta gaatgcatgc tcagcgagtg cactgctctt tgtgaaaata     3360

gaaaaaatga actggagcag ttaaaggaaa catttgcaaa ggaacagcaa gaattcttaa     3420

caaaattagc tttcgctgaa gagcaaaaca ggaaactaat gctagagttg gagatagagc     3480

aacaaactgt gagatccgag attacaaaca ccaacaagca ttccatgagt gcgactgatg     3540

gcttaaggca agaatgcttg actttaaacg aagagcaaaa tgagcagcaa aacgaagtta     3600

gcaacttaac acatgagaat gagcaactga tggagttaac acagaccaaa catgattctt     3660

atctcgcagt agagccagtt gagaactctg taaaagcaac cgaagatgag ataggtaaga     3720

gtagttccca gtaccagatg gatatcgaca ctaaagacat ttctctagat agttataagg     3780

cacagctggt acatctagaa gctttggtaa gaattctgga agtacagctt gaccaaagtg     3840

aggaggagaa caagaagctg catctggaat tacagacgat tagagaggag ctagaaacca     3900

agagttcaca ggacccccag tcacaggcaa ggactgggct taaagactgt gacacagcag     3960

aagaaaagta tgtgtccatg ctacaggagt tgtcagcaag tcaaaacgag aatgcacact     4020

tacagtgctc tctacagaca gcagtgaaca aactgaatga gctagggaaa atgtgtgacg     4080

tattgagagt tgaaaagtta cagctagagt ctgagctgaa tgactcacgg acagagtgta     4140

tcacggcaac tagtcagatg acggcagagg tcgagaagct agtgagtgaa atgaaaatgc     4200

taaaccacga gagtgctctg tcccagaatg agctgatgaa ggacacctca ggtggtgaat     4260

ttcatgataa agcaaaccac agttctgtgt tcttgactcc tttggacagt agcaatttct     4320

gtgaacagat gaccttgtca agcaaagagg tccgagtgca ctttgctgaa ttacaggaga     4380

aattctcctg tttacaaagt gaacacaaaa ttttacatga tcagcactgt gaggtgagct     4440

ctaagatgtc agcactgcgt tcctacgtgg acacattaaa agctgaaaat tctgccttgt     4500

caatgagtct gagaaccttg cagggtgact tggtaaagga gggggagcct gcagctgagg     4560

gtgggcatgg tctgccactg tcgttctgtg gggcagacag cccgtctctg acaaattttg     4620

gagaaacgtc cttttacaaa gacgttttag aacaaactgg agacacatgt catctaagtt     4680

tagaagggaa cgcttcagca aattcttgtg acttggatga agagttctcc agcagtctgg     4740

aggaggagac tctgactgag aaggaaagcc cacctgcccc tgggaggact gttgagggac     4800

ttgaagtcct atgccaggtg tacttgcagt ccctcaagaa tctagaggag aaaactgaga     4860

gccaaaggat tatgaaaaat aaagaaattg aaaagcttga gcagttactg agttctgaga     4920

ggaaagagct aagctgcctt aggaagcagt atttgtcaga aaaggagcaa tggcagcaga     4980

agctaacaag tgtcactttg gaaatggagt ccaagttagc agaggagaag cagcagacca     5040

agactctgtc ccttgaactt gaggtagcac gacttcagtt acaggagctg gacctgagct     5100

ccaggtcttt gcttggcact gacttggaaa gtgttgttcg gtgccaaaac gataattatg     5160

atataaaaga atcagaagta tatatttcag agactacaga gaaaacacca aagcaggaca     5220

ctgaccaaac ttgtgataaa gatattcagc aggaccttgg tctggaaact tcagtcactg     5280

agagtgagac taccaggctc acaggagagg ggtgtgaaga gcagcctccg aagaccaatt     5340

gtgaggcacc agcggaggac aaaacccagg actgctcaga atgcatttct gaattgtgtt     5400

ctagttccaa tgttttggtg cccatggatg ttctggaaga tcaggggtct atccagaatc     5460

tccagttgca gaaagacacc ttaaatgaga atttgagatt acttcctgaa gtagaggact     5520

gggacaaaaa agttgaaagt ttgctaaatg aaattatgga ggcagattca aaactgagtt     5580

tacaggaagt acagctcaag atgaagattg caacatgcat acaattggaa aaaatagtca     5640

aggacctcag aaaggaaaaa gctgacttaa gtgaaaagtt ggaatccctt ccatgtaacc     5700

aggaggtatg tctgagagta gaaaggtcag aagaagatct tggttttaat ttagatatgg     5760

gagcaaatga gttgttaagt aaatctacta aagataatgc aaccaacaca gaagacaatt     5820

ataaggagaa gtttcttgat atggaaagag aactgaccag aattaagtct gagaaagcta     5880

atattgagca tcacatccta tctgtggaaa ctaacttaga ggtggttcaa gcagagaagc     5940

tctgtttgga aagagacact gaaagtaagc aaaaggttat tattgacctt aaagaagaac     6000

tatttacagt tataagtgag agaaacagac ttcgggaaga attagataat gtgtcaaaag     6060

aaagcaaagc actggatcag atgtctaaaa agatgaaaga gaaaatagaa gagctggagt     6120

ctcaccaaag ggagagcctc cgtcacattg gggcagtaga gtctgaggtc aaggacaaag     6180

cagatcttat tcagactctg tcctttaatg tgggtgagct aacaaaagac aaagctcatc     6240

tccaggagca gctgcagaat ttgcagaatg actcacaaga attatctttg gcgattggtg     6300

agctggaaat acaaattgga caactgaata aagagaaaga atcactggtc aaggagtctc     6360

agaacttcca gatcaagctg actgagtcag agtgtgaaaa gcagacgatc tctaaggcct     6420

tggaggtggc actcaaggag aaaggtgagt ttgcagtgca gctgagctca gcccaggagg     6480

aggtgcatca gctgagacga ggcattgaga aactgagcgt ccgcattgag gccgatgaga     6540

agaagcacct cagtgctgtg gcgaagctga aagaaagcca gcgtgaaagc gactcattga     6600

aggatacagt ggagactctg gagcgggaac tggagaggtc agaagaaaac caagagctgg     6660

caattcttga ttctgagaat ttgaaagcag aggtggagac ccttaaggca caaaaggatg     6720

aaatgaccaa aagcctgaga attttcgaat tagaccttgt tacagttagg actgaaagag     6780

aaaatctagc aaagcagcta caagagaaac aaagtcgagt gtcagaatta gatgaacggt     6840

gctcttcctt gagaagactg ttggaagaga aggagcaagc aagagtacag atggaagaag     6900

actctaagtc tgcaatgctg atgcttcaga tgcagttaaa agaactcagg gaggaagtgg     6960

cagccttgtg taatgaccaa gaaaccttga aggcccaaga acagagtcta gaccaaccag     7020

gggaggaagt gcatcatttg aaaagtagca ttcgaaagct caaagttcac atagatgctg     7080

atgaaaagaa gcatcaaaac atcctagaac aactgaagga aagtaagcac catgcagact     7140

tgcttaagga ccgagttgag aaccttgaac aagaattgat actatcagag aaaaacatga     7200

ttttccaagc tgaaaagtcc aaagcagaga tacagacttt aaaatcagaa attcaaagaa     7260

tggcccaaaa cctccaagac ttgcagttag aacttattag tacaaggtca gaaaatgaaa     7320

atctcatgaa agaattaaaa aaagagcaag agcgagtatc tgacttagaa acaataaatt     7380

cttctattga aaacttactg aaagataaag agcaagaaaa agtacagatg aaagaggaag     7440

ccaaaataac agtggagatg cttcaaactc aattaaagga gctaaacgag acagtggttt     7500

ccttgtgcaa tgaccaagag gtctctaaga ccaaagaaca gaatctgggt agtcaagtac     7560

aaactcttga acttgagaag gctcagctgc tacaggacct tggtgaggcc aagaataaat     7620

atattatttt tcagtcatct gtaaatgccc tcactcaaga agtagaagct ggcaaacaga     7680

aactagagaa gggggagaaa gagatcagga cactgaaaga gcaacttaaa agtcaggagc     7740

agcttgtgtg taaacttgcc caagtggaag gagagcagca actctggcag aagcagaaac     7800

tagagctgag aaatgtgact atggcactgg agcagaaggt ccaagtgctg caatctgaaa     7860

acaacacgtt gcagagcacc tatgaagcac tgcagaattc ccacaagagt ttagagagtg     7920

aacttggatt gataaagttg gagaaagtag cgcttgttga aagagttagc acaatatctg     7980

ggaaggaagc agagctgcag agggagctgc gagatatgct acagaaaaca acacagctga     8040

gcgaagacta caataaagag aaaaacaggc taacagaaga agtggaagtg ctgcgtgaag     8100

aactgcagaa caccaaagca gcgcacctga aatctgtgaa tcaacttgag aaggaacttc     8160

agcgtgctca ggggaaaata aagttgatgc tcaaatcctg tagacagctg gaaggagaaa     8220

aggagatgct gcagaaggag ctctcccagc ttgaagctgc acagcagcag agagcaggtt     8280

ctcttgtaga cagtaacgta gatgaagtaa tgactgagaa caaagcgctg aaagagactc     8340

tggaagaaaa agtcaaggaa gcagataagt acttggataa gtactgttcc ctgctgataa     8400

gccacgagga gctcgagaaa gccaaggaga tattagaaat agaagttgct cggctgaagt     8460

cacggcagtc cagacaggat ctccagagtt ctcctttgct taattcttcc attccaggac     8520

cgtctccaaa tacttctgtt agtgagatga agtcagcatc tggccaaaat aaagcttcag     8580

gcaagaggca aaggtccagt gggatttggg agcatggtaa acgggcagca ccttctacag     8640

cagagacatt ttctaagaaa agcaggaagt cggacagtaa gagcactcgc cctgctgagc     8700

acgagcagga aaccgagttt gagccagaag gcctcccaga agtcgttaaa aaagggtttg     8760

ctgacatccc aactggaaag acaagcccat atatccttcg gagaacaacc atggcaacca     8820

ggaccagccc ccgctttgct acacagaagt tagtgggatc ttccccatct ctgggcaaag     8880

aaaatgttgt agagtcctcc aaaccaacag ctggtggcag cagatcacaa aaggtcaagg     8940

ttgttcagga gagctcagcg gattcacaca ctgccttcca agaactccca gcaaaatctc     9000

tcacagccag taatattcct gggagaaact ctacagagag ccccagggag ggcctgaggg     9060

ccaagcgggc ctaccctgcc tccagcccag ctgctgggcc tgatcccacg aacaacgaaa     9120

actgccgggt ccagtgaagt gtccactcag ggttctggaa ggtggcatta ctcaaaggag     9180

cctgcctgtg gggacttgtc ttgagccaag gacacattat gtatcactag agaatacctg     9240

agtctttatg ctgtgtgtgt ggtgctcagg tctcccatat gtaagactgc aaacgttgaa     9300

agcacccatt acctagtagt cctaatcctt aaccctaagt gtaaatagca gtggatagag     9360

cgagagcatt tgctgcagtt aaatgggaag cgccatgatt tgtatgtgca ttttacactt     9420

gctactgcag tgatttgatt aggatcttcc tgtgtagatt gttaggcatc aaatcgttgt     9480

agatcaagag ttggagctga gttaagtgag gacagcctgt gtgcacagtg tgtggtatgg     9540

tcctcctttc tgtgtgtttc ataacttcct gcttctctga cctgtccata gcgtgtgggg     9600

agtttgcagt gtgcacttac tactagttag tctgattgtt tcatacactt ttgtggtggt     9660

gtagatcatg tttactgtca ctgttttcct gtcatcatag ttcttttggt atatatttct     9720

gtgtctggtg atatattaaa gtatgtcctt gtaaactttt ttgtaaaagt tatttcctaa     9780

atataaaaac attatgacta gcaccactat gtcttcttaa ctaaaaccac ctcccataaa     9840

agtaaaaatg tttgaacaaa tgatacatgt ctttgaatgt gtgatactag tatacttact     9900

gaacgtgaga catactgtag aatgttggtc atacagatgg tttgagaata tggatatatt     9960

aaactagtat cttgtgctca ttaaatacta ttagcaaagg tacaagaatg ttcccatctg    10020

tctgttgata atagggcttg aaaagatgaa ggcattttga ctcaataaca aatgaaaaca    10080

cttgactaag cctctgtgcc gttgaataaa ggtgaaaggt tttccggctt taagttagta    10140

gtagatgatc tgttcttggc tttcatttca gattggtatc aaatgttcac aaacacagtc    10200

attttagatt tgaaaactgt ctcctgctgg tggtttcact gttggaatat aaaccactcc    10260

atcccctgag agcgatgctc tactctctca ggttgctcct gtcccaaggc caccatgtgc    10320

tccagcgctg aggtcaggcc agcagcttta agggatgcca caagagatgg aaagatccca    10380

tgccagggtg tcaccaagta ctttccagcg tccttaggaa tggcgtcctc ttcttgtagg    10440

ccatagctcc tctgtgacat gggatacttg cattcccaga agcaatggac tcatcttttg    10500

gttgcgtgcc aagctgaggg taaagaatgg cttgtttgtt gctgcaaatg aggaatatgt    10560

agacgatggt ccttggagag cagtatctga atagaaagca aaaggctttc attggtgaaa    10620

taccaggcat catgtgtgga cacatttctg aacatgttct gtgtggggtg agaaggtaat    10680

gacaggttca ttgtgtagcc tggctgccac aggtctcatc tgcctgcatc tgtctcccag    10740

gtcctgggat taaatgcgta taccaccaag cttgcaggtc agtgtttgaa ctttaatatt    10800

tataatccct tttcacatga gactctgtac ctggtatata atacaaatca gatgtgtact    10860

gataaattga aagtttattt tagactgaga atgtgactca gtgttcaagt attgtgtagt    10920

atgctcaaga acaggctttg aggggctggt gagatggctc agtgggtaag agcacctgac    10980

tgctcttctg aaggtccgga gttcaaatcc cagcaaccac atggtggctc acaaccatct    11040

gtaacgaaat ctggcaccct cttctggagt gactgaagac agctacagtg tacttacata    11100

taataaataa ataaatcttt aaaaaaaaaa                                     11130


<210>  56
<211>  2997
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Mouse centromere protein F

<400>  56

Met Ser Trp Ala Leu Glu Glu Trp Lys Glu Gly Leu Pro Ser Arg Ala 
1               5                   10                  15      


Leu Gln Lys Ile Gln Glu Leu Glu Gly Gln Leu Glu Lys Leu Lys Lys 
            20                  25                  30          


Glu Lys Gln Gln Arg Gln Phe Gln Leu Asp Ser Leu Glu Ala Ala Leu 
        35                  40                  45              


Gln Lys Gln Lys Gln Lys Val Glu Asp Gly Lys Thr Glu Gly Ala Asp 
    50                  55                  60                  


Leu Lys Arg Glu Asn Gln Arg Leu Met Glu Ile Cys Glu His Leu Glu 
65                  70                  75                  80  


Lys Ser Arg Gln Lys Leu Ser His Glu Leu Gln Val Lys Glu Ser Gln 
                85                  90                  95      


Val Asn Leu Gln Glu Ser Gln Leu Ser Ser Cys Lys Lys Gln Ile Glu 
            100                 105                 110         


Lys Leu Glu Gln Glu Leu Lys Arg Cys Lys Ser Glu Phe Glu Arg Ser 
        115                 120                 125             


Gln Gln Val Ala Gln Ser Ala Asp Val Ser Leu Asn Pro Cys Ser Thr 
    130                 135                 140                 


Pro Gln Lys Leu Phe Ala Thr Pro Leu Thr Pro Ser Ser Thr Tyr Glu 
145                 150                 155                 160 


Asp Leu Lys Glu Lys Tyr Asn Lys Glu Val Glu Glu Arg Lys Arg Leu 
                165                 170                 175     


Glu Glu Glu Val Lys Ala Leu His Ala Lys Lys Val Ser Leu Pro Val 
            180                 185                 190         


Ser Gln Ala Thr Met Asn His Arg Asp Ile Ala Arg His Gln Ala Ser 
        195                 200                 205             


Ser Ser Val Phe Pro Trp Gln Gln Glu Asn Thr Pro Ser Arg Leu Ser 
    210                 215                 220                 


Ser Asp Ala Leu Lys Thr Pro Leu Arg Arg Asp Gly Ser Ala Ala His 
225                 230                 235                 240 


Phe Leu Gly Glu Glu Val Ser Pro Asn Lys Ser Ser Met Lys Thr Gly 
                245                 250                 255     


Arg Gly Asp Cys Ser Ser Leu Pro Gly Glu Pro His Ser Ala Gln Leu 
            260                 265                 270         


Leu His Gln Ala Lys Ala Gln Asn Gln Asp Leu Lys Ser Lys Met Thr 
        275                 280                 285             


Glu Leu Glu Leu Arg Leu Gln Gly Gln Glu Lys Glu Met Arg Ser Gln 
    290                 295                 300                 


Val Asn Lys Cys Gln Asp Leu Gln Leu Gln Leu Glu Lys Thr Lys Val 
305                 310                 315                 320 


Glu Leu Ile Glu Lys Glu Arg Ile Leu Asn Lys Thr Arg Asp Glu Val 
                325                 330                 335     


Val Arg Ser Thr Ala Gln Tyr Asp Gln Ala Ala Ala Lys Cys Thr Thr 
            340                 345                 350         


Leu Glu Gln Lys Leu Lys Thr Leu Thr Glu Glu Leu Ser Cys His Arg 
        355                 360                 365             


Gln Asn Ala Glu Ser Ala Lys Arg Ser Leu Glu Gln Arg Ile Lys Glu 
    370                 375                 380                 


Lys Glu Lys Glu Leu Gln Glu Glu Leu Ser Arg Gln His Gln Ser Phe 
385                 390                 395                 400 


Gln Ala Leu Asp Ser Glu Tyr Thr Gln Met Lys Thr Arg Leu Thr Gln 
                405                 410                 415     


Glu Leu Gln Gln Val Lys His Leu His Ser Thr Leu Gln Leu Glu Leu 
            420                 425                 430         


Glu Lys Val Thr Ser Val Lys Gln Gln Leu Glu Arg Asn Leu Glu Glu 
        435                 440                 445             


Ile Arg Leu Lys Leu Ser Arg Ala Glu Gln Ala Leu Gln Ala Ser Gln 
    450                 455                 460                 


Val Ala Glu Asn Glu Leu Arg Arg Ser Ser Glu Glu Met Lys Lys Glu 
465                 470                 475                 480 


Asn Ser Leu Ile Arg Ser Gln Ser Glu Gln Arg Thr Arg Glu Val Cys 
                485                 490                 495     


His Leu Glu Glu Glu Leu Gly Lys Val Lys Val Ser Leu Ser Lys Ser 
            500                 505                 510         


Gln Asn Phe Ala Glu Glu Met Lys Ala Lys Asn Thr Ser Gln Glu Ile 
        515                 520                 525             


Met Leu Arg Asp Leu Gln Glu Lys Leu Asn Gln Gln Glu Asn Ser Leu 
    530                 535                 540                 


Thr Leu Glu Lys Leu Lys Leu Ala Leu Ala Asp Leu Glu Arg Gln Arg 
545                 550                 555                 560 


Asn Cys Ser Gln Asp Leu Leu Lys Lys Arg Glu His His Ile Asp Gln 
                565                 570                 575     


Leu Asn Asn Lys Leu Asn Lys Ile Glu Lys Glu Phe Glu Thr Leu Leu 
            580                 585                 590         


Ser Ala Leu Glu Leu Lys Lys Lys Glu Cys Glu Glu Leu Lys Glu Glu 
        595                 600                 605             


Lys Asn Gln Ile Ser Phe Trp Lys Ile Asp Ser Glu Lys Leu Ile Asn 
    610                 615                 620                 


Gln Ile Glu Ser Glu Lys Glu Ile Leu Leu Gly Lys Ile Asn His Leu 
625                 630                 635                 640 


Glu Thr Ser Leu Lys Thr Gln Gln Val Ser Pro Asp Ser Asn Glu Arg 
                645                 650                 655     


Ile Arg Thr Leu Glu Met Glu Arg Glu Asn Phe Thr Val Glu Ile Lys 
            660                 665                 670         


Asn Leu Gln Ser Met Leu Asp Ser Lys Met Val Glu Ile Lys Thr Gln 
        675                 680                 685             


Lys Gln Ala Tyr Leu Glu Leu Gln Gln Lys Ser Glu Ser Ser Asp Gln 
    690                 695                 700                 


Lys His Gln Lys Glu Ile Glu Asn Met Cys Leu Lys Ala Asn Lys Leu 
705                 710                 715                 720 


Thr Gly Gln Val Glu Ser Leu Glu Cys Lys Leu Gln Leu Leu Ser Ser 
                725                 730                 735     


Glu Val Val Thr Lys Asp Gln Gln Tyr Gln Asp Leu Arg Met Glu Tyr 
            740                 745                 750         


Glu Thr Leu Arg Asp Leu Leu Lys Ser Arg Gly Ser Ser Leu Val Thr 
        755                 760                 765             


Asn Glu Asp Asn Gln Arg Ser Ser Glu Asp Asn Gln Arg Ser Ser Glu 
    770                 775                 780                 


Asp Asn Gln Arg Gly Ser Leu Ala Phe Glu Gln Gln Pro Ala Val Ser 
785                 790                 795                 800 


Asp Ser Phe Ala Asn Val Met Gly Arg Lys Gly Ser Ile Asn Ser Glu 
                805                 810                 815     


Arg Ser Asp Cys Ser Val Asp Gly Gly Arg Ser Pro Glu His Ile Ala 
            820                 825                 830         


Ile Leu Gln Asn Arg Val Thr Ser Leu Glu Ser Ser Leu Glu Ser Gln 
        835                 840                 845             


Asn Gln Met Asn Ser Asp Leu Gln Met Arg Cys Glu Glu Leu Leu Gln 
    850                 855                 860                 


Ile Lys Gly Glu Val Glu Glu Asn Leu Ser Lys Ala Glu Gln Ile His 
865                 870                 875                 880 


Gln Asn Phe Val Ala Glu Thr Asn Gln Cys Ile Ser Lys Leu Gln Glu 
                885                 890                 895     


Asp Ala Ala Val His Gln Asn Ile Val Ala Glu Thr Leu Ala Thr Leu 
            900                 905                 910         


Glu Ser Lys Glu Lys Glu Leu Gln Leu Leu Lys Glu Lys Leu Glu Ala 
        915                 920                 925             


Gln Gln Thr Glu Val Gln Lys Leu Asn Lys Asn Asn Cys Leu Leu Glu 
    930                 935                 940                 


Gly Thr Leu Lys Glu Leu Gln Leu Leu Ser Asp Thr Leu Ser Ser Glu 
945                 950                 955                 960 


Lys Lys Glu Met Asn Ser Ile Ile Ser Leu Ser Lys Lys Asn Ile Glu 
                965                 970                 975     


Glu Leu Thr Gln Ala Asn Glu Ala Leu Lys Glu Val Asn Glu Ala Leu 
            980                 985                 990         


Glu Gln Glu Lys Met Asn Leu Leu  Gln Lys His Glu Lys  Ile Thr Ser 
        995                 1000                 1005             


Cys Ile  Ala Glu Gln Glu Arg  Ser Ile Ala Glu Leu  Ser Asp Gln 
    1010                 1015                 1020             


Tyr Lys  Gln Glu Arg Leu Gln  Leu Leu Gln Arg Cys  Glu Glu Thr 
    1025                 1030                 1035             


Glu Ala  Val Leu Glu Asp Leu  Arg Gly Asn Tyr Lys  Thr Ala Gln 
    1040                 1045                 1050             


Glu Asn  Asn Ala Lys Leu Glu  Cys Met Leu Ser Glu  Cys Thr Ala 
    1055                 1060                 1065             


Leu Cys  Glu Asn Arg Lys Asn  Glu Leu Glu Gln Leu  Lys Glu Thr 
    1070                 1075                 1080             


Phe Ala  Lys Glu Gln Gln Glu  Phe Leu Thr Lys Leu  Ala Phe Ala 
    1085                 1090                 1095             


Glu Glu  Gln Asn Arg Lys Leu  Met Leu Glu Leu Glu  Ile Glu Gln 
    1100                 1105                 1110             


Gln Thr  Val Arg Ser Glu Ile  Thr Asn Thr Asn Lys  His Ser Met 
    1115                 1120                 1125             


Ser Ala  Thr Asp Gly Leu Arg  Gln Glu Cys Leu Thr  Leu Asn Glu 
    1130                 1135                 1140             


Glu Gln  Asn Glu Gln Gln Asn  Glu Val Ser Asn Leu  Thr His Glu 
    1145                 1150                 1155             


Asn Glu  Gln Leu Met Glu Leu  Thr Gln Thr Lys His  Asp Ser Tyr 
    1160                 1165                 1170             


Leu Ala  Val Glu Pro Val Glu  Asn Ser Val Lys Ala  Thr Glu Asp 
    1175                 1180                 1185             


Glu Ile  Gly Lys Ser Ser Ser  Gln Tyr Gln Met Asp  Ile Asp Thr 
    1190                 1195                 1200             


Lys Asp  Ile Ser Leu Asp Ser  Tyr Lys Ala Gln Leu  Val His Leu 
    1205                 1210                 1215             


Glu Ala  Leu Val Arg Ile Leu  Glu Val Gln Leu Asp  Gln Ser Glu 
    1220                 1225                 1230             


Glu Glu  Asn Lys Lys Leu His  Leu Glu Leu Gln Thr  Ile Arg Glu 
    1235                 1240                 1245             


Glu Leu  Glu Thr Lys Ser Ser  Gln Asp Pro Gln Ser  Gln Ala Arg 
    1250                 1255                 1260             


Thr Gly  Leu Lys Asp Cys Asp  Thr Ala Glu Glu Lys  Tyr Val Ser 
    1265                 1270                 1275             


Met Leu  Gln Glu Leu Ser Ala  Ser Gln Asn Glu Asn  Ala His Leu 
    1280                 1285                 1290             


Gln Cys  Ser Leu Gln Thr Ala  Val Asn Lys Leu Asn  Glu Leu Gly 
    1295                 1300                 1305             


Lys Met  Cys Asp Val Leu Arg  Val Glu Lys Leu Gln  Leu Glu Ser 
    1310                 1315                 1320             


Glu Leu  Asn Asp Ser Arg Thr  Glu Cys Ile Thr Ala  Thr Ser Gln 
    1325                 1330                 1335             


Met Thr  Ala Glu Val Glu Lys  Leu Val Ser Glu Met  Lys Met Leu 
    1340                 1345                 1350             


Asn His  Glu Ser Ala Leu Ser  Gln Asn Glu Leu Met  Lys Asp Thr 
    1355                 1360                 1365             


Ser Gly  Gly Glu Phe His Asp  Lys Ala Asn His Ser  Ser Val Phe 
    1370                 1375                 1380             


Leu Thr  Pro Leu Asp Ser Ser  Asn Phe Cys Glu Gln  Met Thr Leu 
    1385                 1390                 1395             


Ser Ser  Lys Glu Val Arg Val  His Phe Ala Glu Leu  Gln Glu Lys 
    1400                 1405                 1410             


Phe Ser  Cys Leu Gln Ser Glu  His Lys Ile Leu His  Asp Gln His 
    1415                 1420                 1425             


Cys Glu  Val Ser Ser Lys Met  Ser Ala Leu Arg Ser  Tyr Val Asp 
    1430                 1435                 1440             


Thr Leu  Lys Ala Glu Asn Ser  Ala Leu Ser Met Ser  Leu Arg Thr 
    1445                 1450                 1455             


Leu Gln  Gly Asp Leu Val Lys  Glu Gly Glu Pro Ala  Ala Glu Gly 
    1460                 1465                 1470             


Gly His  Gly Leu Pro Leu Ser  Phe Cys Gly Ala Asp  Ser Pro Ser 
    1475                 1480                 1485             


Leu Thr  Asn Phe Gly Glu Thr  Ser Phe Tyr Lys Asp  Val Leu Glu 
    1490                 1495                 1500             


Gln Thr  Gly Asp Thr Cys His  Leu Ser Leu Glu Gly  Asn Ala Ser 
    1505                 1510                 1515             


Ala Asn  Ser Cys Asp Leu Asp  Glu Glu Phe Ser Ser  Ser Leu Glu 
    1520                 1525                 1530             


Glu Glu  Thr Leu Thr Glu Lys  Glu Ser Pro Pro Ala  Pro Gly Arg 
    1535                 1540                 1545             


Thr Val  Glu Gly Leu Glu Val  Leu Cys Gln Val Tyr  Leu Gln Ser 
    1550                 1555                 1560             


Leu Lys  Asn Leu Glu Glu Lys  Thr Glu Ser Gln Arg  Ile Met Lys 
    1565                 1570                 1575             


Asn Lys  Glu Ile Glu Lys Leu  Glu Gln Leu Leu Ser  Ser Glu Arg 
    1580                 1585                 1590             


Lys Glu  Leu Ser Cys Leu Arg  Lys Gln Tyr Leu Ser  Glu Lys Glu 
    1595                 1600                 1605             


Gln Trp  Gln Gln Lys Leu Thr  Ser Val Thr Leu Glu  Met Glu Ser 
    1610                 1615                 1620             


Lys Leu  Ala Glu Glu Lys Gln  Gln Thr Lys Thr Leu  Ser Leu Glu 
    1625                 1630                 1635             


Leu Glu  Val Ala Arg Leu Gln  Leu Gln Glu Leu Asp  Leu Ser Ser 
    1640                 1645                 1650             


Arg Ser  Leu Leu Gly Thr Asp  Leu Glu Ser Val Val  Arg Cys Gln 
    1655                 1660                 1665             


Asn Asp  Asn Tyr Asp Ile Lys  Glu Ser Glu Val Tyr  Ile Ser Glu 
    1670                 1675                 1680             


Thr Thr  Glu Lys Thr Pro Lys  Gln Asp Thr Asp Gln  Thr Cys Asp 
    1685                 1690                 1695             


Lys Asp  Ile Gln Gln Asp Leu  Gly Leu Glu Thr Ser  Val Thr Glu 
    1700                 1705                 1710             


Ser Glu  Thr Thr Arg Leu Thr  Gly Glu Gly Cys Glu  Glu Gln Pro 
    1715                 1720                 1725             


Pro Lys  Thr Asn Cys Glu Ala  Pro Ala Glu Asp Lys  Thr Gln Asp 
    1730                 1735                 1740             


Cys Ser  Glu Cys Ile Ser Glu  Leu Cys Ser Ser Ser  Asn Val Leu 
    1745                 1750                 1755             


Val Pro  Met Asp Val Leu Glu  Asp Gln Gly Ser Ile  Gln Asn Leu 
    1760                 1765                 1770             


Gln Leu  Gln Lys Asp Thr Leu  Asn Glu Asn Leu Arg  Leu Leu Pro 
    1775                 1780                 1785             


Glu Val  Glu Asp Trp Asp Lys  Lys Val Glu Ser Leu  Leu Asn Glu 
    1790                 1795                 1800             


Ile Met  Glu Ala Asp Ser Lys  Leu Ser Leu Gln Glu  Val Gln Leu 
    1805                 1810                 1815             


Lys Met  Lys Ile Ala Thr Cys  Ile Gln Leu Glu Lys  Ile Val Lys 
    1820                 1825                 1830             


Asp Leu  Arg Lys Glu Lys Ala  Asp Leu Ser Glu Lys  Leu Glu Ser 
    1835                 1840                 1845             


Leu Pro  Cys Asn Gln Glu Val  Cys Leu Arg Val Glu  Arg Ser Glu 
    1850                 1855                 1860             


Glu Asp  Leu Gly Phe Asn Leu  Asp Met Gly Ala Asn  Glu Leu Leu 
    1865                 1870                 1875             


Ser Lys  Ser Thr Lys Asp Asn  Ala Thr Asn Thr Glu  Asp Asn Tyr 
    1880                 1885                 1890             


Lys Glu  Lys Phe Leu Asp Met  Glu Arg Glu Leu Thr  Arg Ile Lys 
    1895                 1900                 1905             


Ser Glu  Lys Ala Asn Ile Glu  His His Ile Leu Ser  Val Glu Thr 
    1910                 1915                 1920             


Asn Leu  Glu Val Val Gln Ala  Glu Lys Leu Cys Leu  Glu Arg Asp 
    1925                 1930                 1935             


Thr Glu  Ser Lys Gln Lys Val  Ile Ile Asp Leu Lys  Glu Glu Leu 
    1940                 1945                 1950             


Phe Thr  Val Ile Ser Glu Arg  Asn Arg Leu Arg Glu  Glu Leu Asp 
    1955                 1960                 1965             


Asn Val  Ser Lys Glu Ser Lys  Ala Leu Asp Gln Met  Ser Lys Lys 
    1970                 1975                 1980             


Met Lys  Glu Lys Ile Glu Glu  Leu Glu Ser His Gln  Arg Glu Ser 
    1985                 1990                 1995             


Leu Arg  His Ile Gly Ala Val  Glu Ser Glu Val Lys  Asp Lys Ala 
    2000                 2005                 2010             


Asp Leu  Ile Gln Thr Leu Ser  Phe Asn Val Gly Glu  Leu Thr Lys 
    2015                 2020                 2025             


Asp Lys  Ala His Leu Gln Glu  Gln Leu Gln Asn Leu  Gln Asn Asp 
    2030                 2035                 2040             


Ser Gln  Glu Leu Ser Leu Ala  Ile Gly Glu Leu Glu  Ile Gln Ile 
    2045                 2050                 2055             


Gly Gln  Leu Asn Lys Glu Lys  Glu Ser Leu Val Lys  Glu Ser Gln 
    2060                 2065                 2070             


Asn Phe  Gln Ile Lys Leu Thr  Glu Ser Glu Cys Glu  Lys Gln Thr 
    2075                 2080                 2085             


Ile Ser  Lys Ala Leu Glu Val  Ala Leu Lys Glu Lys  Gly Glu Phe 
    2090                 2095                 2100             


Ala Val  Gln Leu Ser Ser Ala  Gln Glu Glu Val His  Gln Leu Arg 
    2105                 2110                 2115             


Arg Gly  Ile Glu Lys Leu Ser  Val Arg Ile Glu Ala  Asp Glu Lys 
    2120                 2125                 2130             


Lys His  Leu Ser Ala Val Ala  Lys Leu Lys Glu Ser  Gln Arg Glu 
    2135                 2140                 2145             


Ser Asp  Ser Leu Lys Asp Thr  Val Glu Thr Leu Glu  Arg Glu Leu 
    2150                 2155                 2160             


Glu Arg  Ser Glu Glu Asn Gln  Glu Leu Ala Ile Leu  Asp Ser Glu 
    2165                 2170                 2175             


Asn Leu  Lys Ala Glu Val Glu  Thr Leu Lys Ala Gln  Lys Asp Glu 
    2180                 2185                 2190             


Met Thr  Lys Ser Leu Arg Ile  Phe Glu Leu Asp Leu  Val Thr Val 
    2195                 2200                 2205             


Arg Thr  Glu Arg Glu Asn Leu  Ala Lys Gln Leu Gln  Glu Lys Gln 
    2210                 2215                 2220             


Ser Arg  Val Ser Glu Leu Asp  Glu Arg Cys Ser Ser  Leu Arg Arg 
    2225                 2230                 2235             


Leu Leu  Glu Glu Lys Glu Gln  Ala Arg Val Gln Met  Glu Glu Asp 
    2240                 2245                 2250             


Ser Lys  Ser Ala Met Leu Met  Leu Gln Met Gln Leu  Lys Glu Leu 
    2255                 2260                 2265             


Arg Glu  Glu Val Ala Ala Leu  Cys Asn Asp Gln Glu  Thr Leu Lys 
    2270                 2275                 2280             


Ala Gln  Glu Gln Ser Leu Asp  Gln Pro Gly Glu Glu  Val His His 
    2285                 2290                 2295             


Leu Lys  Ser Ser Ile Arg Lys  Leu Lys Val His Ile  Asp Ala Asp 
    2300                 2305                 2310             


Glu Lys  Lys His Gln Asn Ile  Leu Glu Gln Leu Lys  Glu Ser Lys 
    2315                 2320                 2325             


His His  Ala Asp Leu Leu Lys  Asp Arg Val Glu Asn  Leu Glu Gln 
    2330                 2335                 2340             


Glu Leu  Ile Leu Ser Glu Lys  Asn Met Ile Phe Gln  Ala Glu Lys 
    2345                 2350                 2355             


Ser Lys  Ala Glu Ile Gln Thr  Leu Lys Ser Glu Ile  Gln Arg Met 
    2360                 2365                 2370             


Ala Gln  Asn Leu Gln Asp Leu  Gln Leu Glu Leu Ile  Ser Thr Arg 
    2375                 2380                 2385             


Ser Glu  Asn Glu Asn Leu Met  Lys Glu Leu Lys Lys  Glu Gln Glu 
    2390                 2395                 2400             


Arg Val  Ser Asp Leu Glu Thr  Ile Asn Ser Ser Ile  Glu Asn Leu 
    2405                 2410                 2415             


Leu Lys  Asp Lys Glu Gln Glu  Lys Val Gln Met Lys  Glu Glu Ala 
    2420                 2425                 2430             


Lys Ile  Thr Val Glu Met Leu  Gln Thr Gln Leu Lys  Glu Leu Asn 
    2435                 2440                 2445             


Glu Thr  Val Val Ser Leu Cys  Asn Asp Gln Glu Val  Ser Lys Thr 
    2450                 2455                 2460             


Lys Glu  Gln Asn Leu Gly Ser  Gln Val Gln Thr Leu  Glu Leu Glu 
    2465                 2470                 2475             


Lys Ala  Gln Leu Leu Gln Asp  Leu Gly Glu Ala Lys  Asn Lys Tyr 
    2480                 2485                 2490             


Ile Ile  Phe Gln Ser Ser Val  Asn Ala Leu Thr Gln  Glu Val Glu 
    2495                 2500                 2505             


Ala Gly  Lys Gln Lys Leu Glu  Lys Gly Glu Lys Glu  Ile Arg Thr 
    2510                 2515                 2520             


Leu Lys  Glu Gln Leu Lys Ser  Gln Glu Gln Leu Val  Cys Lys Leu 
    2525                 2530                 2535             


Ala Gln  Val Glu Gly Glu Gln  Gln Leu Trp Gln Lys  Gln Lys Leu 
    2540                 2545                 2550             


Glu Leu  Arg Asn Val Thr Met  Ala Leu Glu Gln Lys  Val Gln Val 
    2555                 2560                 2565             


Leu Gln  Ser Glu Asn Asn Thr  Leu Gln Ser Thr Tyr  Glu Ala Leu 
    2570                 2575                 2580             


Gln Asn  Ser His Lys Ser Leu  Glu Ser Glu Leu Gly  Leu Ile Lys 
    2585                 2590                 2595             


Leu Glu  Lys Val Ala Leu Val  Glu Arg Val Ser Thr  Ile Ser Gly 
    2600                 2605                 2610             


Lys Glu  Ala Glu Leu Gln Arg  Glu Leu Arg Asp Met  Leu Gln Lys 
    2615                 2620                 2625             


Thr Thr  Gln Leu Ser Glu Asp  Tyr Asn Lys Glu Lys  Asn Arg Leu 
    2630                 2635                 2640             


Thr Glu  Glu Val Glu Val Leu  Arg Glu Glu Leu Gln  Asn Thr Lys 
    2645                 2650                 2655             


Ala Ala  His Leu Lys Ser Val  Asn Gln Leu Glu Lys  Glu Leu Gln 
    2660                 2665                 2670             


Arg Ala  Gln Gly Lys Ile Lys  Leu Met Leu Lys Ser  Cys Arg Gln 
    2675                 2680                 2685             


Leu Glu  Gly Glu Lys Glu Met  Leu Gln Lys Glu Leu  Ser Gln Leu 
    2690                 2695                 2700             


Glu Ala  Ala Gln Gln Gln Arg  Ala Gly Ser Leu Val  Asp Ser Asn 
    2705                 2710                 2715             


Val Asp  Glu Val Met Thr Glu  Asn Lys Ala Leu Lys  Glu Thr Leu 
    2720                 2725                 2730             


Glu Glu  Lys Val Lys Glu Ala  Asp Lys Tyr Leu Asp  Lys Tyr Cys 
    2735                 2740                 2745             


Ser Leu  Leu Ile Ser His Glu  Glu Leu Glu Lys Ala  Lys Glu Ile 
    2750                 2755                 2760             


Leu Glu  Ile Glu Val Ala Arg  Leu Lys Ser Arg Gln  Ser Arg Gln 
    2765                 2770                 2775             


Asp Leu  Gln Ser Ser Pro Leu  Leu Asn Ser Ser Ile  Pro Gly Pro 
    2780                 2785                 2790             


Ser Pro  Asn Thr Ser Val Ser  Glu Met Lys Ser Ala  Ser Gly Gln 
    2795                 2800                 2805             


Asn Lys  Ala Ser Gly Lys Arg  Gln Arg Ser Ser Gly  Ile Trp Glu 
    2810                 2815                 2820             


His Gly  Lys Arg Ala Ala Pro  Ser Thr Ala Glu Thr  Phe Ser Lys 
    2825                 2830                 2835             


Lys Ser  Arg Lys Ser Asp Ser  Lys Ser Thr Arg Pro  Ala Glu His 
    2840                 2845                 2850             


Glu Gln  Glu Thr Glu Phe Glu  Pro Glu Gly Leu Pro  Glu Val Val 
    2855                 2860                 2865             


Lys Lys  Gly Phe Ala Asp Ile  Pro Thr Gly Lys Thr  Ser Pro Tyr 
    2870                 2875                 2880             


Ile Leu  Arg Arg Thr Thr Met  Ala Thr Arg Thr Ser  Pro Arg Phe 
    2885                 2890                 2895             


Ala Thr  Gln Lys Leu Val Gly  Ser Ser Pro Ser Leu  Gly Lys Glu 
    2900                 2905                 2910             


Asn Val  Val Glu Ser Ser Lys  Pro Thr Ala Gly Gly  Ser Arg Ser 
    2915                 2920                 2925             


Gln Lys  Val Lys Val Val Gln  Glu Ser Ser Ala Asp  Ser His Thr 
    2930                 2935                 2940             


Ala Phe  Gln Glu Leu Pro Ala  Lys Ser Leu Thr Ala  Ser Asn Ile 
    2945                 2950                 2955             


Pro Gly  Arg Asn Ser Thr Glu  Ser Pro Arg Glu Gly  Leu Arg Ala 
    2960                 2965                 2970             


Lys Arg  Ala Tyr Pro Ala Ser  Ser Pro Ala Ala Gly  Pro Asp Pro 
    2975                 2980                 2985             


Thr Asn  Asn Glu Asn Cys Arg  Val Gln 
    2990                 2995         


