                         SEQUENCE LISTING

<110>  iQur Limited
 
<120>  VACCINES BASED ON HEPATITIS B CORE ANTIGENS

<130>  N402200WO

<150>  GB1402890.6
<151>  2014-02-18

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  639
<212>  DNA
<213>  Hepatitis B virus


<220>
<221>  CDS
<222>  (1)..(639)

<400>  1
atg caa ctt ttt cac ctc tgc cta atc atc tct tgt tca tgt cct act         48
Met Gln Leu Phe His Leu Cys Leu Ile Ile Ser Cys Ser Cys Pro Thr           
1               5                   10                  15                

gtt caa gcc tcc aag ctg tgc ctt ggg tgg ctt tgg ggc atg gac atc         96
Val Gln Ala Ser Lys Leu Cys Leu Gly Trp Leu Trp Gly Met Asp Ile           
            20                  25                  30                    

gac cct tat aaa gaa ttt gga gct act gtg gag tta ctc tcg ttt ttg        144
Asp Pro Tyr Lys Glu Phe Gly Ala Thr Val Glu Leu Leu Ser Phe Leu           
        35                  40                  45                        

cct tct gac ttc ttt cct tca gta cga gat ctt cta gat acc gcc tca        192
Pro Ser Asp Phe Phe Pro Ser Val Arg Asp Leu Leu Asp Thr Ala Ser           
    50                  55                  60                            

gct ctg tat cgg gaa gcc tta gag tct cct gag cat tgt tca cct cac        240
Ala Leu Tyr Arg Glu Ala Leu Glu Ser Pro Glu His Cys Ser Pro His           
65                  70                  75                  80            

cat act gca ctc agg caa gca att ctt tgc tgg ggg gaa cta atg act        288
His Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp Gly Glu Leu Met Thr           
                85                  90                  95                

cta gct acc tgg gtg ggt gtt aat ttg gaa gat cca gcg tct aga gac        336
Leu Ala Thr Trp Val Gly Val Asn Leu Glu Asp Pro Ala Ser Arg Asp           
            100                 105                 110                   

cta gta gtc agt tat gtc aac act aat atg ggc cta aag ttc agg caa        384
Leu Val Val Ser Tyr Val Asn Thr Asn Met Gly Leu Lys Phe Arg Gln           
        115                 120                 125                       

ctc ttg tgg ttt cac att tct tgt ctc act ttt gga aga gaa aca gtt        432
Leu Leu Trp Phe His Ile Ser Cys Leu Thr Phe Gly Arg Glu Thr Val           
    130                 135                 140                           

ata gag tat ttg gtg tct ttc gga gtg tgg att cgc act cct cca gct        480
Ile Glu Tyr Leu Val Ser Phe Gly Val Trp Ile Arg Thr Pro Pro Ala           
145                 150                 155                 160           

tat aga cca cca aat gcc cct atc cta tca aca ctt ccg gag act act        528
Tyr Arg Pro Pro Asn Ala Pro Ile Leu Ser Thr Leu Pro Glu Thr Thr           
                165                 170                 175               

gtt gtt aga cga cga ggc agg tcc cct aga aga aga act ccc tcg cct        576
Val Val Arg Arg Arg Gly Arg Ser Pro Arg Arg Arg Thr Pro Ser Pro           
            180                 185                 190                   

cgc aga cga agg tct caa tcg ccg cgt cgc aga aga tct caa tct cgg        624
Arg Arg Arg Arg Ser Gln Ser Pro Arg Arg Arg Arg Ser Gln Ser Arg           
        195                 200                 205                       

gaa tct caa tgt tag                                                    639
Glu Ser Gln Cys                                                           
    210                                                                   


<210>  2
<211>  212
<212>  PRT
<213>  Hepatitis B virus

<400>  2

Met Gln Leu Phe His Leu Cys Leu Ile Ile Ser Cys Ser Cys Pro Thr 
1               5                   10                  15      


Val Gln Ala Ser Lys Leu Cys Leu Gly Trp Leu Trp Gly Met Asp Ile 
            20                  25                  30          


Asp Pro Tyr Lys Glu Phe Gly Ala Thr Val Glu Leu Leu Ser Phe Leu 
        35                  40                  45              


Pro Ser Asp Phe Phe Pro Ser Val Arg Asp Leu Leu Asp Thr Ala Ser 
    50                  55                  60                  


Ala Leu Tyr Arg Glu Ala Leu Glu Ser Pro Glu His Cys Ser Pro His 
65                  70                  75                  80  


His Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp Gly Glu Leu Met Thr 
                85                  90                  95      


Leu Ala Thr Trp Val Gly Val Asn Leu Glu Asp Pro Ala Ser Arg Asp 
            100                 105                 110         


Leu Val Val Ser Tyr Val Asn Thr Asn Met Gly Leu Lys Phe Arg Gln 
        115                 120                 125             


Leu Leu Trp Phe His Ile Ser Cys Leu Thr Phe Gly Arg Glu Thr Val 
    130                 135                 140                 


Ile Glu Tyr Leu Val Ser Phe Gly Val Trp Ile Arg Thr Pro Pro Ala 
145                 150                 155                 160 


Tyr Arg Pro Pro Asn Ala Pro Ile Leu Ser Thr Leu Pro Glu Thr Thr 
                165                 170                 175     


Val Val Arg Arg Arg Gly Arg Ser Pro Arg Arg Arg Thr Pro Ser Pro 
            180                 185                 190         


Arg Arg Arg Arg Ser Gln Ser Pro Arg Arg Arg Arg Ser Gln Ser Arg 
        195                 200                 205             


Glu Ser Gln Cys 
    210         


<210>  3
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence HBcAg may comprise

<400>  3

Ala Ala Ala Leu Ala Ala Ala 
1               5           


<210>  4
<211>  334
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CoHo7e construct

<400>  4

Met Asp Ile Asp Pro Tyr Lys Glu Phe Gly Ala Thr Val Glu Leu Leu 
1               5                   10                  15      


Ser Phe Leu Pro Ser Asp Phe Phe Pro Ser Val Arg Asp Leu Leu Asp 
            20                  25                  30          


Thr Ala Ser Ala Leu Tyr Arg Glu Ala Leu Glu Ser Pro Glu His Cys 
        35                  40                  45              


Ser Pro His His Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp Gly Glu 
    50                  55                  60                  


Leu Met Thr Leu Ala Thr Trp Val Gly Asn Asn Leu Glu Gly Ser Ala 
65                  70                  75                  80  


Gly Gly Gly Arg Asp Pro Ala Ser Arg Asp Leu Val Val Asn Tyr Val 
                85                  90                  95      


Asn Thr Asn Met Gly Leu Lys Ile Arg Gln Leu Leu Trp Phe His Ile 
            100                 105                 110         


Ser Cys Leu Thr Phe Gly Arg Glu Thr Val Leu Glu Tyr Leu Val Ser 
        115                 120                 125             


Phe Gly Val Trp Ile Arg Thr Pro Pro Ala Tyr Arg Pro Pro Asn Ala 
    130                 135                 140                 


Pro Ile Leu Ser Thr Leu Pro Glu Thr Thr Val Val Gly Gly Ser Ser 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
                165                 170                 175     


Gly Ser Thr Met Asp Ile Asp Pro Tyr Lys Glu Phe Gly Ala Thr Val 
            180                 185                 190         


Glu Leu Leu Ser Phe Leu Pro Ser Asp Phe Phe Pro Ser Val Arg Asp 
        195                 200                 205             


Leu Leu Asp Thr Ala Ser Ala Leu Tyr Arg Glu Ala Leu Glu Ser Pro 
    210                 215                 220                 


Glu His Cys Ser Pro His His Thr Ala Leu Arg Gln Ala Ile Leu Cys 
225                 230                 235                 240 


Trp Gly Glu Leu Met Thr Leu Ala Thr Trp Val Gly Asn Asn Leu Glu 
                245                 250                 255     


Phe Ala Gly Ala Ser Asp Pro Ala Ser Arg Asp Leu Val Val Asn Tyr 
            260                 265                 270         


Val Asn Thr Asn Met Gly Leu Lys Ile Arg Gln Leu Leu Trp Phe His 
        275                 280                 285             


Ile Ser Cys Leu Thr Phe Gly Arg Glu Thr Val Leu Glu Tyr Leu Val 
    290                 295                 300                 


Ser Phe Gly Val Trp Ile Arg Thr Pro Pro Ala Tyr Arg Pro Pro Asn 
305                 310                 315                 320 


Ala Pro Ile Leu Ser Thr Leu Pro Glu Thr Thr Val Val Leu 
                325                 330                 


<210>  5
<211>  328
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H3Ho construct

<400>  5

Met Ser Asp Ile Asp Pro Tyr Lys Glu Phe Gly Ala Thr Val Glu Leu 
1               5                   10                  15      


Leu Ser Phe Leu Pro Ser Asp Phe Phe Pro Ser Val Arg Asp Leu Leu 
            20                  25                  30          


Asp Thr Ala Ser Ala Leu Tyr Arg Glu Ala Leu Glu Ser Pro Glu His 
        35                  40                  45              


Cys Ser Pro His His Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp Gly 
    50                  55                  60                  


Glu Leu Met Thr Leu Ala Thr Trp Val Ala Ala Ala Leu Ala Ala Ala 
65                  70                  75                  80  


Glu Gly Ser Asp Pro Ala Ser Arg Asp Leu Val Val Asn Tyr Val Asn 
                85                  90                  95      


Thr Asn Met Gly Leu Lys Ile Arg Gln Leu Leu Trp Phe His Ile Ser 
            100                 105                 110         


Cys Leu Thr Phe Gly Arg Glu Thr Val Leu Glu Tyr Leu Val Ser Phe 
        115                 120                 125             


Gly Val Trp Ile Arg Thr Pro Pro Ala Tyr Arg Pro Pro Asn Ala Pro 
    130                 135                 140                 


Ile Leu Ser Thr Leu Pro Glu Thr Thr Val Val Gly Gly Ser Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Thr Met Asp Ile Asp 
                165                 170                 175     


Pro Tyr Lys Glu Phe Gly Ala Thr Val Glu Leu Leu Ser Phe Leu Pro 
            180                 185                 190         


Ser Asp Phe Phe Pro Ser Val Arg Asp Leu Leu Asp Thr Ala Ser Ala 
        195                 200                 205             


Leu Tyr Arg Glu Ala Leu Glu Ser Pro Glu His Cys Ser Pro His His 
    210                 215                 220                 


Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp Gly Glu Leu Met Thr Leu 
225                 230                 235                 240 


Ala Thr Trp Val Ala Ala Ala Leu Ala Ala Ala Glu Ser Gly Asp Pro 
                245                 250                 255     


Ala Ser Arg Asp Leu Val Val Asn Tyr Val Asn Thr Asn Met Gly Leu 
            260                 265                 270         


Lys Ile Arg Gln Leu Leu Trp Phe His Ile Ser Cys Leu Thr Phe Gly 
        275                 280                 285             


Arg Glu Thr Val Leu Glu Tyr Leu Val Ser Phe Gly Val Trp Ile Arg 
    290                 295                 300                 


Thr Pro Pro Ala Tyr Arg Pro Pro Asn Ala Pro Ile Leu Ser Thr Leu 
305                 310                 315                 320 


Pro Glu Thr Thr Val Val Leu Glu 
                325             


<210>  6
<211>  682
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LolC-empty construct

<400>  6

Met Asp Ile Asp Pro Tyr Lys Glu Phe Gly Ala Thr Val Glu Leu Leu 
1               5                   10                  15      


Ser Phe Leu Pro Ser Asp Phe Phe Pro Ser Val Arg Asp Leu Leu Asp 
            20                  25                  30          


Thr Ala Ser Ala Leu Tyr Arg Glu Ala Leu Glu Ser Pro Glu His Cys 
        35                  40                  45              


Ser Pro His His Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp Gly Glu 
    50                  55                  60                  


Leu Met Thr Leu Ala Thr Trp Val Ala Ala Ala Leu Ala Ala Ala Glu 
65                  70                  75                  80  


Gly Ser Ala Leu Gly Val Ala Ala Leu Ile Val Val Leu Ser Val Met 
                85                  90                  95      


Asn Gly Phe Gln Lys Glu Val Arg Asp Arg Met Leu Ser Val Leu Ala 
            100                 105                 110         


His Val Glu Ile Phe Ser Pro Thr Gly Ser Met Pro Asp Trp Gln Leu 
        115                 120                 125             


Thr Ala Lys Glu Ala Arg Leu Asn Arg Ser Val Ile Gly Ala Ala Pro 
    130                 135                 140                 


Tyr Val Asp Ala Gln Ala Leu Leu Thr Arg Gln Asp Ala Val Ser Gly 
145                 150                 155                 160 


Val Met Leu Arg Gly Val Glu Pro Ser Leu Glu Pro Gln Val Ser Asp 
                165                 170                 175     


Ile Gly Lys Asp Met Lys Ala Gly Ala Leu Thr Ala Leu Ala Pro Gly 
            180                 185                 190         


Gln Phe Gly Ile Val Leu Gly Asn Ala Leu Ala Gly Asn Leu Gly Val 
        195                 200                 205             


Gly Val Gly Asp Lys Val Thr Leu Val Ala Pro Glu Gly Thr Ile Thr 
    210                 215                 220                 


Pro Ala Gly Met Met Pro Arg Leu Lys Gln Phe Thr Val Val Gly Ile 
225                 230                 235                 240 


Phe Glu Ser Gly His Tyr Glu Tyr Asp Ser Thr Leu Ala Met Ile Asp 
                245                 250                 255     


Ile Gln Asp Ala Gln Ala Leu Phe Arg Leu Pro Ala Pro Thr Gly Val 
            260                 265                 270         


Arg Leu Arg Leu Thr Asp Met Gln Lys Ala Pro Gln Val Ala Arg Glu 
        275                 280                 285             


Leu Ala His Thr Leu Ser Gly Asp Leu Tyr Ile Arg Asp Trp Thr Gln 
    290                 295                 300                 


Gln Asn Lys Thr Trp Phe Ser Ala Val Gln Ile Glu Lys Arg Met Met 
305                 310                 315                 320 


Phe Ile Ile Leu Thr Leu Ile Ile Ala Val Ala Ala Phe Asn Leu Val 
                325                 330                 335     


Ser Ser Leu Val Met Thr Val Thr Asn Lys Gln Ala Asp Ile Ala Ile 
            340                 345                 350         


Leu Arg Thr Leu Gly Ala Gln Pro Gly Ser Ile Met Lys Ile Phe Val 
        355                 360                 365             


Val Gln Gly Val Thr Ile Gly Phe Val Gly Thr Ala Thr Gly Val Ala 
    370                 375                 380                 


Leu Gly Cys Leu Ile Ala Trp Ser Ile Pro Trp Leu Ile Pro Met Ile 
385                 390                 395                 400 


Glu His Ala Phe Gly Val Gln Phe Leu Pro Pro Ser Val Tyr Phe Ile 
                405                 410                 415     


Ser Glu Leu Pro Ser Glu Leu Val Ala Gly Asp Val Ile Lys Ile Gly 
            420                 425                 430         


Val Ile Ala Gly Ser Asp Pro Ala Ser Arg Asp Leu Val Val Asn Tyr 
        435                 440                 445             


Val Asn Thr Asn Met Gly Leu Lys Ile Arg Gln Leu Leu Trp Phe His 
    450                 455                 460                 


Ile Ser Cys Leu Thr Phe Gly Arg Glu Thr Val Leu Glu Tyr Leu Val 
465                 470                 475                 480 


Ser Phe Gly Val Trp Ile Arg Thr Pro Pro Ala Tyr Arg Pro Pro Asn 
                485                 490                 495     


Ala Pro Ile Leu Ser Thr Leu Pro Glu Thr Thr Val Val Gly Gly Ser 
            500                 505                 510         


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Thr Met Asp 
        515                 520                 525             


Ile Asp Pro Tyr Lys Glu Phe Gly Ala Thr Val Glu Leu Leu Ser Phe 
    530                 535                 540                 


Leu Pro Ser Asp Phe Phe Pro Ser Val Arg Asp Leu Leu Asp Thr Ala 
545                 550                 555                 560 


Ser Ala Leu Tyr Arg Glu Ala Leu Glu Ser Pro Glu His Cys Ser Pro 
                565                 570                 575     


His His Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp Gly Glu Leu Met 
            580                 585                 590         


Thr Leu Ala Thr Trp Val Ala Ala Ala Leu Ala Ala Ala Glu Ser Gly 
        595                 600                 605             


Asp Pro Ala Ser Arg Asp Leu Val Val Asn Tyr Val Asn Thr Asn Met 
    610                 615                 620                 


Gly Leu Lys Ile Arg Gln Leu Leu Trp Phe His Ile Ser Cys Leu Thr 
625                 630                 635                 640 


Phe Gly Arg Glu Thr Val Leu Glu Tyr Leu Val Ser Phe Gly Val Trp 
                645                 650                 655     


Ile Arg Thr Pro Pro Ala Tyr Arg Pro Pro Asn Ala Pro Ile Leu Ser 
            660                 665                 670         


Thr Leu Pro Glu Thr Thr Val Val Leu Glu 
        675                 680         


<210>  7
<211>  698
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LolC-K6 construct

<400>  7

Met Asp Ile Asp Pro Tyr Lys Glu Phe Gly Ala Thr Val Glu Leu Leu 
1               5                   10                  15      


Ser Phe Leu Pro Ser Asp Phe Phe Pro Ser Val Arg Asp Leu Leu Asp 
            20                  25                  30          


Thr Ala Ser Ala Leu Tyr Arg Glu Ala Leu Glu Ser Pro Glu His Cys 
        35                  40                  45              


Ser Pro His His Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp Gly Glu 
    50                  55                  60                  


Leu Met Thr Leu Ala Thr Trp Val Ala Ala Ala Leu Ala Ala Ala Glu 
65                  70                  75                  80  


Gly Ser Ala Leu Gly Val Ala Ala Leu Ile Val Val Leu Ser Val Met 
                85                  90                  95      


Asn Gly Phe Gln Lys Glu Val Arg Asp Arg Met Leu Ser Val Leu Ala 
            100                 105                 110         


His Val Glu Ile Phe Ser Pro Thr Gly Ser Met Pro Asp Trp Gln Leu 
        115                 120                 125             


Thr Ala Lys Glu Ala Arg Leu Asn Arg Ser Val Ile Gly Ala Ala Pro 
    130                 135                 140                 


Tyr Val Asp Ala Gln Ala Leu Leu Thr Arg Gln Asp Ala Val Ser Gly 
145                 150                 155                 160 


Val Met Leu Arg Gly Val Glu Pro Ser Leu Glu Pro Gln Val Ser Asp 
                165                 170                 175     


Ile Gly Lys Asp Met Lys Ala Gly Ala Leu Thr Ala Leu Ala Pro Gly 
            180                 185                 190         


Gln Phe Gly Ile Val Leu Gly Asn Ala Leu Ala Gly Asn Leu Gly Val 
        195                 200                 205             


Gly Val Gly Asp Lys Val Thr Leu Val Ala Pro Glu Gly Thr Ile Thr 
    210                 215                 220                 


Pro Ala Gly Met Met Pro Arg Leu Lys Gln Phe Thr Val Val Gly Ile 
225                 230                 235                 240 


Phe Glu Ser Gly His Tyr Glu Tyr Asp Ser Thr Leu Ala Met Ile Asp 
                245                 250                 255     


Ile Gln Asp Ala Gln Ala Leu Phe Arg Leu Pro Ala Pro Thr Gly Val 
            260                 265                 270         


Arg Leu Arg Leu Thr Asp Met Gln Lys Ala Pro Gln Val Ala Arg Glu 
        275                 280                 285             


Leu Ala His Thr Leu Ser Gly Asp Leu Tyr Ile Arg Asp Trp Thr Gln 
    290                 295                 300                 


Gln Asn Lys Thr Trp Phe Ser Ala Val Gln Ile Glu Lys Arg Met Met 
305                 310                 315                 320 


Phe Ile Ile Leu Thr Leu Ile Ile Ala Val Ala Ala Phe Asn Leu Val 
                325                 330                 335     


Ser Ser Leu Val Met Thr Val Thr Asn Lys Gln Ala Asp Ile Ala Ile 
            340                 345                 350         


Leu Arg Thr Leu Gly Ala Gln Pro Gly Ser Ile Met Lys Ile Phe Val 
        355                 360                 365             


Val Gln Gly Val Thr Ile Gly Phe Val Gly Thr Ala Thr Gly Val Ala 
    370                 375                 380                 


Leu Gly Cys Leu Ile Ala Trp Ser Ile Pro Trp Leu Ile Pro Met Ile 
385                 390                 395                 400 


Glu His Ala Phe Gly Val Gln Phe Leu Pro Pro Ser Val Tyr Phe Ile 
                405                 410                 415     


Ser Glu Leu Pro Ser Glu Leu Val Ala Gly Asp Val Ile Lys Ile Gly 
            420                 425                 430         


Val Ile Ala Gly Ser Asp Pro Ala Ser Arg Asp Leu Val Val Asn Tyr 
        435                 440                 445             


Val Asn Thr Asn Met Gly Leu Lys Ile Arg Gln Leu Leu Trp Phe His 
    450                 455                 460                 


Ile Ser Cys Leu Thr Phe Gly Arg Glu Thr Val Leu Glu Tyr Leu Val 
465                 470                 475                 480 


Ser Phe Gly Val Trp Ile Arg Thr Pro Pro Ala Tyr Arg Pro Pro Asn 
                485                 490                 495     


Ala Pro Ile Leu Ser Thr Leu Pro Glu Thr Thr Val Val Gly Gly Ser 
            500                 505                 510         


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Thr Met Asp 
        515                 520                 525             


Ile Asp Pro Tyr Lys Glu Phe Gly Ala Thr Val Glu Leu Leu Ser Phe 
    530                 535                 540                 


Leu Pro Ser Asp Phe Phe Pro Ser Val Arg Asp Leu Leu Asp Thr Ala 
545                 550                 555                 560 


Ser Ala Leu Tyr Arg Glu Ala Leu Glu Ser Pro Glu His Cys Ser Pro 
                565                 570                 575     


His His Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp Gly Glu Leu Met 
            580                 585                 590         


Thr Leu Ala Thr Trp Val Ala Ala Ala Leu Ala Ala Ala Glu Ser Gly 
        595                 600                 605             


Gly Ser Gly Ser Lys Lys Lys Lys Lys Lys Gly Ser Gly Ser Ser Gly 
    610                 615                 620                 


Asp Pro Ala Ser Arg Asp Leu Val Val Asn Tyr Val Asn Thr Asn Met 
625                 630                 635                 640 


Gly Leu Lys Ile Arg Gln Leu Leu Trp Phe His Ile Ser Cys Leu Thr 
                645                 650                 655     


Phe Gly Arg Glu Thr Val Leu Glu Tyr Leu Val Ser Phe Gly Val Trp 
            660                 665                 670         


Ile Arg Thr Pro Pro Ala Tyr Arg Pro Pro Asn Ala Pro Ile Leu Ser 
        675                 680                 685             


Thr Leu Pro Glu Thr Thr Val Val Leu Glu 
    690                 695             


<210>  8
<211>  698
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LolC-K1 construct

<400>  8

Met Asp Ile Asp Pro Tyr Lys Glu Phe Gly Ala Thr Val Glu Leu Leu 
1               5                   10                  15      


Ser Phe Leu Pro Ser Asp Phe Phe Pro Ser Val Arg Asp Leu Leu Asp 
            20                  25                  30          


Thr Ala Ser Ala Leu Tyr Arg Glu Ala Leu Glu Ser Pro Glu His Cys 
        35                  40                  45              


Ser Pro His His Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp Gly Glu 
    50                  55                  60                  


Leu Met Thr Leu Ala Thr Trp Val Ala Ala Ala Leu Ala Ala Ala Glu 
65                  70                  75                  80  


Gly Ser Ala Leu Gly Val Ala Ala Leu Ile Val Val Leu Ser Val Met 
                85                  90                  95      


Asn Gly Phe Gln Lys Glu Val Arg Asp Arg Met Leu Ser Val Leu Ala 
            100                 105                 110         


His Val Glu Ile Phe Ser Pro Thr Gly Ser Met Pro Asp Trp Gln Leu 
        115                 120                 125             


Thr Ala Lys Glu Ala Arg Leu Asn Arg Ser Val Ile Gly Ala Ala Pro 
    130                 135                 140                 


Tyr Val Asp Ala Gln Ala Leu Leu Thr Arg Gln Asp Ala Val Ser Gly 
145                 150                 155                 160 


Val Met Leu Arg Gly Val Glu Pro Ser Leu Glu Pro Gln Val Ser Asp 
                165                 170                 175     


Ile Gly Lys Asp Met Lys Ala Gly Ala Leu Thr Ala Leu Ala Pro Gly 
            180                 185                 190         


Gln Phe Gly Ile Val Leu Gly Asn Ala Leu Ala Gly Asn Leu Gly Val 
        195                 200                 205             


Gly Val Gly Asp Lys Val Thr Leu Val Ala Pro Glu Gly Thr Ile Thr 
    210                 215                 220                 


Pro Ala Gly Met Met Pro Arg Leu Lys Gln Phe Thr Val Val Gly Ile 
225                 230                 235                 240 


Phe Glu Ser Gly His Tyr Glu Tyr Asp Ser Thr Leu Ala Met Ile Asp 
                245                 250                 255     


Ile Gln Asp Ala Gln Ala Leu Phe Arg Leu Pro Ala Pro Thr Gly Val 
            260                 265                 270         


Arg Leu Arg Leu Thr Asp Met Gln Lys Ala Pro Gln Val Ala Arg Glu 
        275                 280                 285             


Leu Ala His Thr Leu Ser Gly Asp Leu Tyr Ile Arg Asp Trp Thr Gln 
    290                 295                 300                 


Gln Asn Lys Thr Trp Phe Ser Ala Val Gln Ile Glu Lys Arg Met Met 
305                 310                 315                 320 


Phe Ile Ile Leu Thr Leu Ile Ile Ala Val Ala Ala Phe Asn Leu Val 
                325                 330                 335     


Ser Ser Leu Val Met Thr Val Thr Asn Lys Gln Ala Asp Ile Ala Ile 
            340                 345                 350         


Leu Arg Thr Leu Gly Ala Gln Pro Gly Ser Ile Met Lys Ile Phe Val 
        355                 360                 365             


Val Gln Gly Val Thr Ile Gly Phe Val Gly Thr Ala Thr Gly Val Ala 
    370                 375                 380                 


Leu Gly Cys Leu Ile Ala Trp Ser Ile Pro Trp Leu Ile Pro Met Ile 
385                 390                 395                 400 


Glu His Ala Phe Gly Val Gln Phe Leu Pro Pro Ser Val Tyr Phe Ile 
                405                 410                 415     


Ser Glu Leu Pro Ser Glu Leu Val Ala Gly Asp Val Ile Lys Ile Gly 
            420                 425                 430         


Val Ile Ala Gly Ser Asp Pro Ala Ser Arg Asp Leu Val Val Asn Tyr 
        435                 440                 445             


Val Asn Thr Asn Met Gly Leu Lys Ile Arg Gln Leu Leu Trp Phe His 
    450                 455                 460                 


Ile Ser Cys Leu Thr Phe Gly Arg Glu Thr Val Leu Glu Tyr Leu Val 
465                 470                 475                 480 


Ser Phe Gly Val Trp Ile Arg Thr Pro Pro Ala Tyr Arg Pro Pro Asn 
                485                 490                 495     


Ala Pro Ile Leu Ser Thr Leu Pro Glu Thr Thr Val Val Gly Gly Ser 
            500                 505                 510         


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Thr Met Asp 
        515                 520                 525             


Ile Asp Pro Tyr Lys Glu Phe Gly Ala Thr Val Glu Leu Leu Ser Phe 
    530                 535                 540                 


Leu Pro Ser Asp Phe Phe Pro Ser Val Arg Asp Leu Leu Asp Thr Ala 
545                 550                 555                 560 


Ser Ala Leu Tyr Arg Glu Ala Leu Glu Ser Pro Glu His Cys Ser Pro 
                565                 570                 575     


His His Thr Ala Leu Arg Gln Ala Ile Leu Cys Trp Gly Glu Leu Met 
            580                 585                 590         


Thr Leu Ala Thr Trp Val Ala Ala Ala Leu Ala Ala Ala Glu Ser Gly 
        595                 600                 605             


Gly Ser Gly Ser Gly Gly Gly Lys Gly Gly Gly Ser Gly Ser Ser Gly 
    610                 615                 620                 


Asp Pro Ala Ser Arg Asp Leu Val Val Asn Tyr Val Asn Thr Asn Met 
625                 630                 635                 640 


Gly Leu Lys Ile Arg Gln Leu Leu Trp Phe His Ile Ser Cys Leu Thr 
                645                 650                 655     


Phe Gly Arg Glu Thr Val Leu Glu Tyr Leu Val Ser Phe Gly Val Trp 
            660                 665                 670         


Ile Arg Thr Pro Pro Ala Tyr Arg Pro Pro Asn Ala Pro Ile Leu Ser 
        675                 680                 685             


Thr Leu Pro Glu Thr Thr Val Val Leu Glu 
    690                 695             


<210>  9
<211>  355
<212>  PRT
<213>  Burkholderia

<400>  9

Ala Leu Gly Val Ala Ala Leu Ile Val Val Leu Ser Val Met Asn Gly 
1               5                   10                  15      


Phe Gln Lys Glu Val Arg Asp Arg Met Leu Ser Val Leu Ala His Val 
            20                  25                  30          


Glu Ile Phe Ser Pro Thr Gly Ser Met Pro Asp Trp Gln Leu Thr Ala 
        35                  40                  45              


Lys Glu Ala Arg Leu Asn Arg Ser Val Ile Gly Ala Ala Pro Tyr Val 
    50                  55                  60                  


Asp Ala Gln Ala Leu Leu Thr Arg Gln Asp Ala Val Ser Gly Val Met 
65                  70                  75                  80  


Leu Arg Gly Val Glu Pro Ser Leu Glu Pro Gln Val Ser Asp Ile Gly 
                85                  90                  95      


Lys Asp Met Lys Ala Gly Ala Leu Thr Ala Leu Ala Pro Gly Gln Phe 
            100                 105                 110         


Gly Ile Val Leu Gly Asn Ala Leu Ala Gly Asn Leu Gly Val Gly Val 
        115                 120                 125             


Gly Asp Lys Val Thr Leu Val Ala Pro Glu Gly Thr Ile Thr Pro Ala 
    130                 135                 140                 


Gly Met Met Pro Arg Leu Lys Gln Phe Thr Val Val Gly Ile Phe Glu 
145                 150                 155                 160 


Ser Gly His Tyr Glu Tyr Asp Ser Thr Leu Ala Met Ile Asp Ile Gln 
                165                 170                 175     


Asp Ala Gln Ala Leu Phe Arg Leu Pro Ala Pro Thr Gly Val Arg Leu 
            180                 185                 190         


Arg Leu Thr Asp Met Gln Lys Ala Pro Gln Val Ala Arg Glu Leu Ala 
        195                 200                 205             


His Thr Leu Ser Gly Asp Leu Tyr Ile Arg Asp Trp Thr Gln Gln Asn 
    210                 215                 220                 


Lys Thr Trp Phe Ser Ala Val Gln Ile Glu Lys Arg Met Met Phe Ile 
225                 230                 235                 240 


Ile Leu Thr Leu Ile Ile Ala Val Ala Ala Phe Asn Leu Val Ser Ser 
                245                 250                 255     


Leu Val Met Thr Val Thr Asn Lys Gln Ala Asp Ile Ala Ile Leu Arg 
            260                 265                 270         


Thr Leu Gly Ala Gln Pro Gly Ser Ile Met Lys Ile Phe Val Val Gln 
        275                 280                 285             


Gly Val Thr Ile Gly Phe Val Gly Thr Ala Thr Gly Val Ala Leu Gly 
    290                 295                 300                 


Cys Leu Ile Ala Trp Ser Ile Pro Trp Leu Ile Pro Met Ile Glu His 
305                 310                 315                 320 


Ala Phe Gly Val Gln Phe Leu Pro Pro Ser Val Tyr Phe Ile Ser Glu 
                325                 330                 335     


Leu Pro Ser Glu Leu Val Ala Gly Asp Val Ile Lys Ile Gly Val Ile 
            340                 345                 350         


Ala Gly Ser 
        355 


