                         SEQUENCE LISTING

<110>  F. Hoffmann-La Roche AG
 
<120>  Blood brain barrier shuttle

<130>  31897WO

<150>  EP14155687.8
<151>  2014-02-19

<160>  47    

<170>  PatentIn version 3.5

<210>  1
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Brain targeting peptide

<400>  1

Leu Tyr Val Leu His Ser Arg Gly Leu Trp Gly Phe Lys Leu 
1               5                   10                  


<210>  2
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Brain targeting peptide

<400>  2

Leu Gly Ser Val Ser 
1               5   


<210>  3
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Brain targeting peptide

<400>  3

Gly Phe Val Arg Phe Arg Leu Ser Asn Thr Arg 
1               5                   10      


<210>  4
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Brain targeting peptide

<400>  4

Lys Val Ala Trp Arg Val Phe Ser Leu Phe Trp Lys 
1               5                   10          


<210>  5
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Brain targeting peptide

<400>  5

Ser Val His Gly Val 
1               5   


<210>  6
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Brain targeting peptide

<400>  6

Gly Arg Pro Gln Lys Ile Asn Gly Ala Arg Val Cys 
1               5                   10          


<210>  7
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Brain targeting peptide

<400>  7

Met Arg Trp Phe Phe Ser His Ala Ser Gln Gly Arg 
1               5                   10          


<210>  8
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Brain targeting peptide

<400>  8

Arg Leu Ser Ser Val Asp Ser Asp Leu Ser Gly Cys 
1               5                   10          


<210>  9
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Brain targeting peptide

<400>  9

Ile Gly Thr Leu Thr Thr 
1               5       


<210>  10
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Brain targeting peptide

<400>  10

Tyr Asn Gln Ser Leu Leu Gln Gly Tyr Arg Tyr Trp 
1               5                   10          


<210>  11
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Brain targeting peptide

<400>  11

Arg Ser Thr Ala Ser Thr Ser Tyr Pro Phe Phe Phe 
1               5                   10          


<210>  12
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Brain targeting peptide

<400>  12

Ile Ser Asn Arg Ser His Lys Gly Leu Met Val Gly 
1               5                   10          


<210>  13
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Brain targeting peptide

<400>  13

Asp Ala Ala Glu Ser Val Leu Val Gly Thr Val Arg 
1               5                   10          


<210>  14
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Brain targeting peptide

<400>  14

Tyr Ala Trp Gly Gly Gly Trp Val Leu Gln Trp Phe 
1               5                   10          


<210>  15
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Brain targeting peptide

<400>  15

Tyr Ser Met Val Phe Val Gly Ile Lys Leu 
1               5                   10  


<210>  16
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Brain targeting peptide

<400>  16

Asp Val Ala Lys Val Ser 
1               5       


<210>  17
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Brain targeting peptide

<400>  17

Arg Arg Pro Ala Pro Leu Ile Met Phe Arg Met Ile 
1               5                   10          


<210>  18
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Brain targeting peptide

<400>  18

Asp Pro Gln Ile Leu Met Gly Val Leu Arg Ser Ile Arg Gly Phe Gly 
1               5                   10                  15      


Val Lys Leu 
            


<210>  19
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Brain targeting peptide

<400>  19

Ser Arg Tyr Ser Ile Gly Gly Asn Asn Gly Val Thr 
1               5                   10          


<210>  20
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Brain targeting peptide

<400>  20

Ser Gly Ser Gly Ile Gly Leu Asp Arg Trp Arg Val 
1               5                   10          


<210>  21
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Brain targeting peptide

<400>  21

Trp Gly Cys Asn Gly Thr Glu Trp Arg Gly Leu Leu Gly Ile Lys Leu 
1               5                   10                  15      


<210>  22
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Brain targeting peptide

<400>  22

Asn Ser His Ala Met Ser Cys 
1               5           


<210>  23
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Brain targeting peptide

<400>  23

Ser Thr Val Val Cys Phe Lys Gly Val Pro Thr Gly 
1               5                   10          


<210>  24
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Brain targeting peptide

<400>  24

Thr Trp Leu Phe Ser Leu Gly 
1               5           


<210>  25
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Brain targeting peptide

<400>  25

Leu Pro Gly Gly Ser Pro Gly His Ile Leu Val Cys 
1               5                   10          


<210>  26
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Brain targeting peptide

<400>  26

Gly Trp Ile Pro Tyr Asp Gly Gly Asn Arg Ala Arg 
1               5                   10          


<210>  27
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Brain targeting peptide

<400>  27

Ser Thr Met Arg Tyr Val Gly Val Thr Cys Leu 
1               5                   10      


<210>  28
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Brain targeting peptide

<400>  28

Gly Cys Ala Ser Pro Ala Ser Thr Ser Phe His Ser 
1               5                   10          


<210>  29
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Brain targeting peptide

<400>  29

Leu Arg Pro Arg Gly Ala Phe Gln Arg Arg Asp Phe Lys Leu 
1               5                   10                  


<210>  30
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Brain targeting peptide

<400>  30

Glu Leu Val His Ala 
1               5   


<210>  31
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Brain targeting peptide

<400>  31

Phe Leu Ile Gln Trp Gly Ala Val Leu Ser Arg Gly 
1               5                   10          


<210>  32
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Brain targeting peptide

<400>  32

Val Arg Asp Trp Ala Tyr Val Tyr Ser Thr Val Leu 
1               5                   10          


<210>  33
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Brain targeting peptide

<400>  33

Thr Ala Val Phe Ser Ala Leu Ser Met Leu Arg Gly 
1               5                   10          


<210>  34
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Brain targeting peptide

<400>  34

Ala Val Glu Ser 
1               


<210>  35
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Brain targeting peptide

<400>  35

Arg Pro Arg Ala Gln Gly Ala Leu 
1               5               


<210>  36
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Brain targeting peptide

<400>  36

Leu Trp Val Ser Val Pro Arg Ala Arg Ile Ile Gln 
1               5                   10          


<210>  37
<211>  67
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer


<220>
<221>  misc_feature
<222>  (16)..(61)
<223>  n  is a, c, g or t; h is a or c

<400>  37
ggggatccga attctnhhnh hnhhnhhnhh nhhnhhnhhn hhnhhnhhnh htaagcttgc       60

ggccgca                                                                 67


<210>  38
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR Primer

<400>  38
tcgaacgccg gcgt                                                         14


<210>  39
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR Primer

<400>  39
ccatctcatc cctgcgtgtc tccgactcag ggagctgtcg tattccagtc                  50


<210>  40
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR Primer

<400>  40
cctatcccct gtgtgccttg gcagtctcag aacccctcaa gacccgttta                  50


<210>  41
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR Primer

<400>  41
agtacgcaat gggccacg                                                     18


<210>  42
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR Primer

<400>  42
gagcgcatat agttcctcc                                                    19


<210>  43
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR Primer

<400>  43
caggagctgt cgtattcc                                                     18


<210>  44
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequencing Primer

<400>  44
aaaaacccct caagacccg                                                    19


<210>  45
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Start insert

<400>  45
gtgatgctcg gggatccgaa t                                                 21


<210>  46
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Stop insert

<400>  46
taagcttgcg gccgcactcg agta                                              24


<210>  47
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Background insert

<400>  47
cctgcaggga tatcccggga gctcgtcgac                                        30


