                         SEQUENCE LISTING

<110>  PRUDENT, James R.
 
<120>  EXTRACELLULAR TARGETED DRUG CONJUGATES

<130>  088915-8009.WO00

<150>  US 61/940,219
<151>  2014-02-14

<150>  US 61/946,314
<151>  2014-02-28

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  903
<212>  DNA
<213>  Homo sapiens

<400>  1
atggccaact gcgagttcag cccggtgtcc ggggacaaac cctgctgccg gctctctagg       60

agagcccaac tctgtcttgg cgtcagtatc ctggtcctga tcctcgtcgt ggtgctcgcg      120

gtggtcgtcc cgaggtggcg ccagcagtgg agcggtccgg gcaccaccaa gcgctttccc      180

gagaccgtcc tggcgcgatg cgtcaagtac actgaaattc atcctgagat gagacatgta      240

gactgccaaa gtgtatggga tgctttcaag ggtgcattta tttcaaaaca tccttgcaac      300

attactgaag aagactatca gccactaatg aagttgggaa ctcagaccgt accttgcaac      360

aagattcttc tttggagcag aataaaagat ctggcccatc agttcacaca ggtccagcgg      420

gacatgttca ccctggagga cacgctgcta ggctaccttg ctgatgacct cacatggtgt      480

ggtgaattca acacttccaa aataaactat caatcttgcc cagactggag aaaggactgc      540

agcaacaacc ctgtttcagt attctggaaa acggtttccc gcaggtttgc agaagctgcc      600

tgtgatgtgg tccatgtgat gctcaatgga tcccgcagta aaatctttga caaaaacagc      660

acttttggga gtgtggaagt ccataatttg caaccagaga aggttcagac actagaggcc      720

tgggtgatac atggtggaag agaagattcc agagacttat gccaggatcc caccataaaa      780

gagctggaat cgattataag caaaaggaat attcaatttt cctgcaagaa tatctacaga      840

cctgacaagt ttcttcagtg tgtgaaaaat cctgaggatt catcttgcac atctgagatc      900

tga                                                                    903


<210>  2
<211>  300
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Asn Cys Glu Phe Ser Pro Val Ser Gly Asp Lys Pro Cys Cys 
1               5                   10                  15      


Arg Leu Ser Arg Arg Ala Gln Leu Cys Leu Gly Val Ser Ile Leu Val 
            20                  25                  30          


Leu Ile Leu Val Val Val Leu Ala Val Val Val Pro Arg Trp Arg Gln 
        35                  40                  45              


Gln Trp Ser Gly Pro Gly Thr Thr Lys Arg Phe Pro Glu Thr Val Leu 
    50                  55                  60                  


Ala Arg Cys Val Lys Tyr Thr Glu Ile His Pro Glu Met Arg His Val 
65                  70                  75                  80  


Asp Cys Gln Ser Val Trp Asp Ala Phe Lys Gly Ala Phe Ile Ser Lys 
                85                  90                  95      


His Pro Cys Asn Ile Thr Glu Glu Asp Tyr Gln Pro Leu Met Lys Leu 
            100                 105                 110         


Gly Thr Gln Thr Val Pro Cys Asn Lys Ile Leu Leu Trp Ser Arg Ile 
        115                 120                 125             


Lys Asp Leu Ala His Gln Phe Thr Gln Val Gln Arg Asp Met Phe Thr 
    130                 135                 140                 


Leu Glu Asp Thr Leu Leu Gly Tyr Leu Ala Asp Asp Leu Thr Trp Cys 
145                 150                 155                 160 


Gly Glu Phe Asn Thr Ser Lys Ile Asn Tyr Gln Ser Cys Pro Asp Trp 
                165                 170                 175     


Arg Lys Asp Cys Ser Asn Asn Pro Val Ser Val Phe Trp Lys Thr Val 
            180                 185                 190         


Ser Arg Arg Phe Ala Glu Ala Ala Cys Asp Val Val His Val Met Leu 
        195                 200                 205             


Asn Gly Ser Arg Ser Lys Ile Phe Asp Lys Asn Ser Thr Phe Gly Ser 
    210                 215                 220                 


Val Glu Val His Asn Leu Gln Pro Glu Lys Val Gln Thr Leu Glu Ala 
225                 230                 235                 240 


Trp Val Ile His Gly Gly Arg Glu Asp Ser Arg Asp Leu Cys Gln Asp 
                245                 250                 255     


Pro Thr Ile Lys Glu Leu Glu Ser Ile Ile Ser Lys Arg Asn Ile Gln 
            260                 265                 270         


Phe Ser Cys Lys Asn Ile Tyr Arg Pro Asp Lys Phe Leu Gln Cys Val 
        275                 280                 285             


Lys Asn Pro Glu Asp Ser Ser Cys Thr Ser Glu Ile 
    290                 295                 300 


<210>  3
<211>  301
<212>  PRT
<213>  Macaca fascicularis

<400>  3

Met Ala Asn Cys Glu Phe Ser Pro Val Ser Gly Asp Lys Pro Cys Cys 
1               5                   10                  15      


Arg Leu Ser Arg Arg Ala Gln Val Cys Leu Gly Val Cys Leu Leu Val 
            20                  25                  30          


Leu Leu Ile Leu Val Val Val Val Ala Val Val Leu Pro Arg Trp Arg 
        35                  40                  45              


Gln Gln Trp Ser Gly Ser Gly Thr Thr Ser Arg Phe Pro Glu Thr Val 
    50                  55                  60                  


Leu Ala Arg Cys Val Lys Tyr Thr Glu Val His Pro Glu Met Arg His 
65                  70                  75                  80  


Val Asp Cys Gln Ser Val Trp Asp Ala Phe Lys Gly Ala Phe Ile Ser 
                85                  90                  95      


Lys Tyr Pro Cys Asn Ile Thr Glu Glu Asp Tyr Gln Pro Leu Val Lys 
            100                 105                 110         


Leu Gly Thr Gln Thr Val Pro Cys Asn Lys Thr Leu Leu Trp Ser Arg 
        115                 120                 125             


Ile Lys Asp Leu Ala His Gln Phe Thr Gln Val Gln Arg Asp Met Phe 
    130                 135                 140                 


Thr Leu Glu Asp Met Leu Leu Gly Tyr Leu Ala Asp Asp Leu Thr Trp 
145                 150                 155                 160 


Cys Gly Glu Phe Asn Thr Phe Glu Ile Asn Tyr Gln Ser Cys Pro Asp 
                165                 170                 175     


Trp Arg Lys Asp Cys Ser Asn Asn Pro Val Ser Val Phe Trp Lys Thr 
            180                 185                 190         


Val Ser Arg Arg Phe Ala Glu Thr Ala Cys Gly Val Val His Val Met 
        195                 200                 205             


Leu Asn Gly Ser Arg Ser Lys Ile Phe Asp Lys Asn Ser Thr Phe Gly 
    210                 215                 220                 


Ser Val Glu Val His Asn Leu Gln Pro Glu Lys Val Gln Ala Leu Glu 
225                 230                 235                 240 


Ala Trp Val Ile His Gly Gly Arg Glu Asp Ser Arg Asp Leu Cys Gln 
                245                 250                 255     


Asp Pro Thr Ile Lys Glu Leu Glu Ser Ile Ile Ser Lys Arg Asn Ile 
            260                 265                 270         


Arg Phe Phe Cys Lys Asn Ile Tyr Arg Pro Asp Lys Phe Leu Gln Cys 
        275                 280                 285             


Val Lys Asn Pro Glu Asp Ser Ser Cys Leu Ser Gly Ile 
    290                 295                 300     


