                         SEQUENCE LISTING

<110>  IMMUNE DESIGN CORP
 
<120>  IMMUNOTHERAPY OF CANCER THROUGH COMBINATION OF LOCAL AND SYSTEMIC
        IMMUNE STIMULATION

<130>  31943/48357

<150>  US-61/940,109
<151>  2014-02-14

<150>  US-61/985,787
<151>  2014-04-29

<150>  US-62/022,070
<151>  2014-07-08

<150>  US-62/072,548
<151>  2014-10-30

<150>  US-62/101,335
<151>  2015-01-08

<160>  45    

<170>  PatentIn version 3.5

<210>  1
<211>  423
<212>  PRT
<213>  Sindbis virus


<220>
<221>  misc_feature
<222>  (160)..(160)
<223>  Xaa can be any naturally occurring amino acid

<400>  1

Ser Val Ile Asp Asp Phe Thr Leu Thr Ser Pro Tyr Leu Gly Thr Cys 
1               5                   10                  15      


Ser Tyr Cys His His Thr Val Pro Cys Phe Ser Pro Val Lys Ile Glu 
            20                  25                  30          


Gln Val Trp Asp Glu Ala Asp Asp Asn Thr Ile Arg Ile Gln Thr Ser 
        35                  40                  45              


Ala Gln Phe Gly Tyr Asp Gln Ser Gly Ala Ala Ser Ala Asn Lys Tyr 
    50                  55                  60                  


Arg Tyr Met Ser Leu Lys Gln Asp His Thr Val Lys Glu Gly Thr Met 
65                  70                  75                  80  


Asp Asp Ile Lys Ile Ser Thr Ser Gly Pro Cys Arg Arg Leu Ser Tyr 
                85                  90                  95      


Lys Gly Tyr Phe Leu Leu Ala Lys Cys Pro Pro Gly Asp Ser Val Thr 
            100                 105                 110         


Val Ser Ile Val Ser Ser Asn Ser Ala Thr Ser Cys Thr Leu Ala Arg 
        115                 120                 125             


Lys Ile Lys Pro Lys Phe Val Gly Arg Glu Lys Tyr Asp Leu Pro Pro 
    130                 135                 140                 


Val His Gly Lys Lys Ile Pro Cys Thr Val Tyr Asp Arg Leu Lys Xaa 
145                 150                 155                 160 


Thr Thr Ala Gly Tyr Ile Thr Met His Arg Pro Arg Pro His Ala Tyr 
                165                 170                 175     


Thr Ser Tyr Leu Glu Glu Ser Ser Gly Lys Val Tyr Ala Lys Pro Pro 
            180                 185                 190         


Ser Gly Lys Asn Ile Thr Tyr Glu Cys Lys Cys Gly Asp Tyr Lys Thr 
        195                 200                 205             


Gly Thr Val Ser Thr Arg Thr Glu Ile Thr Gly Cys Thr Ala Ile Lys 
    210                 215                 220                 


Gln Cys Val Ala Tyr Lys Ser Asp Gln Thr Lys Trp Val Phe Asn Ser 
225                 230                 235                 240 


Pro Asp Leu Ile Arg His Asp Asp His Thr Ala Gln Gly Lys Leu His 
                245                 250                 255     


Leu Pro Phe Lys Leu Ile Pro Ser Thr Cys Met Val Pro Val Ala His 
            260                 265                 270         


Ala Pro Asn Val Ile His Gly Phe Lys His Ile Ser Leu Gln Leu Asp 
        275                 280                 285             


Thr Asp His Leu Thr Leu Leu Thr Thr Arg Arg Leu Gly Ala Asn Pro 
    290                 295                 300                 


Glu Pro Thr Thr Glu Trp Ile Val Gly Lys Thr Val Arg Asn Phe Thr 
305                 310                 315                 320 


Val Asp Arg Asp Gly Leu Glu Tyr Ile Trp Gly Asn His Glu Pro Val 
                325                 330                 335     


Arg Val Tyr Ala Gln Glu Ser Ala Pro Gly Asp Pro His Gly Trp Pro 
            340                 345                 350         


His Glu Ile Val Gln His Tyr Tyr His Arg His Pro Val Tyr Thr Ile 
        355                 360                 365             


Leu Ala Val Ala Ser Ala Thr Val Ala Met Met Ile Gly Val Thr Val 
    370                 375                 380                 


Ala Val Leu Cys Ala Cys Lys Ala Arg Arg Glu Cys Leu Thr Pro Tyr 
385                 390                 395                 400 


Ala Leu Ala Pro Asn Ala Val Ile Pro Thr Ser Leu Ala Leu Leu Cys 
                405                 410                 415     


Cys Val Arg Ser Ala Asn Ala 
            420             


<210>  2
<211>  986
<212>  PRT
<213>  Sindbis virus

<400>  2

Met Ser Ala Ala Pro Leu Val Thr Ala Met Cys Leu Leu Gly Asn Val 
1               5                   10                  15      


Ser Phe Pro Cys Asp Arg Pro Pro Thr Cys Tyr Thr Arg Glu Pro Ser 
            20                  25                  30          


Arg Ala Leu Asp Ile Leu Glu Glu Asn Val Asn His Glu Ala Tyr Asp 
        35                  40                  45              


Thr Leu Leu Asn Ala Ile Leu Arg Cys Gly Ser Ser Gly Ser Val Ile 
    50                  55                  60                  


Asp Asp Phe Thr Leu Thr Ser Pro Tyr Leu Gly Thr Cys Ser Tyr Cys 
65                  70                  75                  80  


His His Thr Val Pro Cys Phe Ser Pro Val Lys Ile Glu Gln Val Trp 
                85                  90                  95      


Asp Glu Ala Asp Asp Asn Thr Ile Arg Ile Gln Thr Ser Ala Gln Phe 
            100                 105                 110         


Gly Tyr Asp Gln Ser Gly Ala Ala Ser Ala Asn Lys Tyr Arg Tyr Met 
        115                 120                 125             


Ser Leu Lys Gln Met Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Thr Val 
    130                 135                 140                 


Lys Glu Gly Thr Met Asp Asp Ile Lys Ile Ser Thr Ser Gly Pro Cys 
145                 150                 155                 160 


Arg Arg Leu Ser Tyr Lys Gly Tyr Phe Leu Leu Ala Lys Cys Pro Pro 
                165                 170                 175     


Gly Asp Ser Val Thr Val Ser Ile Val Ser Ser Asn Ser Ala Thr Ser 
            180                 185                 190         


Cys Thr Leu Ala Arg Lys Ile Lys Pro Lys Phe Val Gly Arg Glu Lys 
        195                 200                 205             


Tyr Asp Leu Pro Pro Val His Gly Lys Lys Ile Pro Cys Thr Val Tyr 
    210                 215                 220                 


Asp Arg Leu Ala Ala Thr Thr Ala Gly Tyr Ile Thr Met His Arg Pro 
225                 230                 235                 240 


Arg Pro His Ala Tyr Thr Ser Tyr Leu Glu Glu Ser Ser Gly Lys Val 
                245                 250                 255     


Tyr Ala Lys Pro Pro Ser Gly Lys Asn Ile Thr Tyr Glu Cys Lys Cys 
            260                 265                 270         


Gly Asp Tyr Lys Thr Gly Thr Val Ser Thr Arg Thr Glu Ile Thr Gly 
        275                 280                 285             


Cys Thr Ala Ile Lys Gln Cys Val Ala Tyr Lys Ser Asp Gln Thr Lys 
    290                 295                 300                 


Trp Val Phe Asn Ser Pro Asp Leu Ile Arg His Asp Asp His Thr Ala 
305                 310                 315                 320 


Gln Gly Lys Leu His Leu Pro Phe Lys Leu Ile Pro Ser Thr Cys Met 
                325                 330                 335     


Val Pro Val Ala His Ala Pro Asn Val Ile His Gly Phe Lys His Ile 
            340                 345                 350         


Ser Leu Gln Leu Asp Thr Asp His Leu Thr Leu Leu Thr Thr Arg Arg 
        355                 360                 365             


Leu Gly Ala Asn Pro Glu Pro Thr Thr Glu Trp Ile Val Gly Lys Thr 
    370                 375                 380                 


Val Arg Asn Phe Thr Val Asp Arg Asp Gly Leu Glu Tyr Ile Trp Gly 
385                 390                 395                 400 


Asn His Glu Pro Val Arg Val Tyr Ala Gln Glu Ser Ala Pro Gly Asp 
                405                 410                 415     


Pro His Gly Trp Pro His Glu Ile Val Gln His Tyr Tyr His Arg His 
            420                 425                 430         


Pro Val Tyr Thr Ile Leu Ala Val Ala Ser Ala Thr Val Ala Met Met 
        435                 440                 445             


Ile Gly Val Thr Val Ala Val Leu Cys Ala Cys Lys Ala Arg Arg Glu 
    450                 455                 460                 


Cys Leu Thr Pro Tyr Ala Leu Ala Pro Asn Ala Val Ile Pro Thr Ser 
465                 470                 475                 480 


Leu Ala Leu Leu Cys Cys Val Arg Ser Ala Asn Ala Glu Thr Phe Thr 
                485                 490                 495     


Glu Thr Met Ser Tyr Leu Trp Ser Asn Ser Gln Pro Phe Phe Trp Val 
            500                 505                 510         


Gln Leu Cys Ile Pro Leu Ala Ala Phe Ile Val Leu Met Arg Cys Cys 
        515                 520                 525             


Ser Cys Cys Leu Pro Phe Leu Val Val Ala Gly Ala Tyr Leu Ala Lys 
    530                 535                 540                 


Val Asp Ala Tyr Glu His Ala Thr Thr Val Pro Asn Val Pro Gln Ile 
545                 550                 555                 560 


Pro Tyr Lys Ala Leu Val Glu Arg Ala Gly Tyr Ala Pro Leu Asn Leu 
                565                 570                 575     


Glu Ile Thr Val Met Ser Ser Glu Val Leu Pro Ser Thr Asn Gln Glu 
            580                 585                 590         


Tyr Ile Thr Cys Lys Phe Thr Thr Val Val Pro Ser Pro Lys Ile Lys 
        595                 600                 605             


Cys Cys Gly Ser Leu Glu Cys Gln Pro Ala Ala His Ala Gly Tyr Thr 
    610                 615                 620                 


Cys Lys Val Phe Gly Gly Val Tyr Pro Phe Met Trp Gly Gly Ala Gln 
625                 630                 635                 640 


Cys Phe Cys Asp Ser Glu Asn Ser Gln Met Ser Glu Ala Tyr Val Glu 
                645                 650                 655     


Leu Ser Ala Asp Cys Ala Ser Asp His Ala Gln Ala Ile Lys Val His 
            660                 665                 670         


Thr Ala Ala Met Lys Val Gly Leu Arg Ile Val Tyr Gly Asn Thr Thr 
        675                 680                 685             


Ser Phe Leu Asp Val Tyr Val Asn Gly Val Thr Pro Gly Thr Ser Lys 
    690                 695                 700                 


Asp Leu Lys Val Ile Ala Gly Pro Ile Ser Ala Ser Phe Thr Pro Phe 
705                 710                 715                 720 


Asp His Lys Val Val Ile His Arg Gly Leu Val Tyr Asn Tyr Asp Phe 
                725                 730                 735     


Pro Glu Tyr Gly Ala Met Lys Pro Gly Ala Phe Gly Asp Ile Gln Ala 
            740                 745                 750         


Thr Ser Leu Thr Ser Lys Asp Leu Ile Ala Ser Thr Asp Ile Arg Leu 
        755                 760                 765             


Leu Lys Pro Ser Ala Lys Asn Val His Val Pro Tyr Thr Gln Ala Ser 
    770                 775                 780                 


Ser Gly Phe Glu Met Trp Lys Asn Asn Ser Gly Arg Pro Leu Gln Glu 
785                 790                 795                 800 


Thr Ala Pro Phe Gly Cys Lys Ile Ala Val Asn Pro Leu Arg Ala Val 
                805                 810                 815     


Asp Cys Ser Tyr Gly Asn Ile Pro Ile Ser Ile Asp Ile Pro Asn Ala 
            820                 825                 830         


Ala Phe Ile Arg Thr Ser Asp Ala Pro Leu Val Ser Thr Val Lys Cys 
        835                 840                 845             


Glu Val Ser Glu Cys Thr Tyr Ser Ala Asp Phe Gly Gly Met Ala Thr 
    850                 855                 860                 


Leu Gln Tyr Val Ser Asp Arg Glu Gly Gln Cys Pro Val His Ser His 
865                 870                 875                 880 


Ser Ser Thr Ala Thr Leu Gln Glu Ser Thr Val His Val Leu Glu Lys 
                885                 890                 895     


Gly Ala Val Thr Val His Phe Ser Thr Ala Ser Pro Gln Ala Asn Phe 
            900                 905                 910         


Ile Val Ser Leu Cys Gly Lys Lys Thr Thr Cys Asn Ala Glu Cys Lys 
        915                 920                 925             


Pro Pro Ala Asp His Ile Val Ser Thr Pro His Lys Asn Asp Gln Glu 
    930                 935                 940                 


Phe Gln Ala Ala Ile Ser Lys Thr Ser Trp Ser Trp Leu Phe Ala Leu 
945                 950                 955                 960 


Phe Gly Gly Ala Ser Ser Leu Leu Ile Ile Gly Leu Met Ile Phe Ala 
                965                 970                 975     


Cys Ser Met Met Leu Thr Ser Thr Arg Arg 
            980                 985     


<210>  3
<211>  982
<212>  PRT
<213>  Sindbis virus

<400>  3

Met Ser Ala Ala Pro Leu Val Thr Ala Met Cys Leu Leu Gly Asn Val 
1               5                   10                  15      


Ser Phe Pro Cys Asp Arg Pro Pro Thr Cys Tyr Thr Arg Glu Pro Ser 
            20                  25                  30          


Arg Ala Leu Asp Ile Leu Glu Glu Asn Val Asn His Glu Ala Tyr Asp 
        35                  40                  45              


Thr Leu Leu Asn Ala Ile Leu Arg Cys Gly Ser Ser Gly Arg Ser Lys 
    50                  55                  60                  


Arg Ser Val Ile Asp Asp Phe Thr Leu Thr Ser Pro Tyr Leu Gly Thr 
65                  70                  75                  80  


Cys Ser Tyr Cys His His Thr Val Pro Cys Phe Ser Pro Val Lys Ile 
                85                  90                  95      


Glu Gln Val Trp Asp Glu Ala Asp Asp Asn Thr Ile Arg Ile Gln Thr 
            100                 105                 110         


Ser Ala Gln Phe Gly Tyr Asp Gln Ser Gly Ala Ala Ser Ala Asn Lys 
        115                 120                 125             


Tyr Arg Tyr Met Ser Leu Glu Gln Asp His Thr Val Lys Glu Gly Thr 
    130                 135                 140                 


Met Asp Asp Ile Lys Ile Ser Thr Ser Gly Pro Cys Arg Arg Leu Ser 
145                 150                 155                 160 


Tyr Lys Gly Tyr Phe Leu Leu Ala Lys Cys Pro Pro Gly Asp Ser Val 
                165                 170                 175     


Thr Val Ser Ile Val Ser Ser Asn Ser Ala Thr Ser Cys Thr Leu Ala 
            180                 185                 190         


Arg Lys Ile Lys Pro Lys Phe Val Gly Arg Glu Lys Tyr Asp Leu Pro 
        195                 200                 205             


Pro Val His Gly Lys Lys Ile Pro Cys Thr Val Tyr Asp Arg Leu Glu 
    210                 215                 220                 


Gly Thr Thr Ala Gly Tyr Ile Thr Met His Arg Pro Arg Pro His Ala 
225                 230                 235                 240 


Tyr Thr Ser Tyr Leu Glu Glu Ser Ser Gly Lys Val Tyr Ala Lys Pro 
                245                 250                 255     


Pro Ser Gly Lys Asn Ile Thr Tyr Glu Cys Lys Cys Gly Asp Tyr Lys 
            260                 265                 270         


Thr Gly Thr Val Ser Thr Arg Thr Glu Ile Thr Gly Cys Thr Ala Ile 
        275                 280                 285             


Lys Gln Cys Val Ala Tyr Lys Ser Asp Gln Thr Lys Trp Val Phe Asn 
    290                 295                 300                 


Ser Pro Asp Leu Ile Arg His Asp Asp His Thr Ala Gln Gly Lys Leu 
305                 310                 315                 320 


His Leu Pro Phe Lys Leu Ile Pro Ser Thr Cys Met Val Pro Val Ala 
                325                 330                 335     


His Ala Pro Asn Val Ile His Gly Phe Lys His Ile Ser Leu Gln Leu 
            340                 345                 350         


Asp Thr Asp His Leu Thr Leu Leu Thr Thr Arg Arg Leu Gly Ala Asn 
        355                 360                 365             


Pro Glu Pro Thr Thr Glu Trp Ile Val Gly Lys Thr Val Arg Asn Phe 
    370                 375                 380                 


Thr Val Asp Arg Asp Gly Leu Glu Tyr Ile Trp Gly Asn His Glu Pro 
385                 390                 395                 400 


Val Arg Val Tyr Ala Gln Glu Ser Ala Pro Gly Asp Pro His Gly Trp 
                405                 410                 415     


Pro His Glu Ile Val Gln His Tyr Tyr His Arg His Pro Val Tyr Thr 
            420                 425                 430         


Ile Leu Ala Val Ala Ser Ala Thr Val Ala Met Met Ile Gly Val Thr 
        435                 440                 445             


Val Ala Val Leu Cys Ala Cys Lys Ala Arg Arg Glu Cys Leu Thr Pro 
    450                 455                 460                 


Tyr Ala Leu Ala Pro Asn Ala Val Ile Pro Thr Ser Leu Ala Leu Leu 
465                 470                 475                 480 


Cys Cys Val Arg Ser Ala Asn Ala Glu Thr Phe Thr Glu Thr Met Ser 
                485                 490                 495     


Tyr Leu Trp Ser Asn Ser Gln Pro Phe Phe Trp Val Gln Leu Cys Ile 
            500                 505                 510         


Pro Leu Ala Ala Phe Ile Val Leu Met Arg Cys Cys Ser Cys Cys Leu 
        515                 520                 525             


Pro Phe Leu Val Val Ala Gly Ala Tyr Leu Ala Lys Val Asp Ala Tyr 
    530                 535                 540                 


Glu His Ala Thr Thr Val Pro Asn Val Pro Gln Ile Pro Tyr Lys Ala 
545                 550                 555                 560 


Leu Val Glu Arg Ala Gly Tyr Ala Pro Leu Asn Leu Glu Ile Thr Val 
                565                 570                 575     


Met Ser Ser Glu Val Leu Pro Ser Thr Asn Gln Glu Tyr Ile Thr Cys 
            580                 585                 590         


Lys Phe Thr Thr Val Val Pro Ser Pro Lys Ile Lys Cys Cys Gly Ser 
        595                 600                 605             


Leu Glu Cys Gln Pro Ala Ala His Ala Asp Tyr Thr Cys Lys Val Phe 
    610                 615                 620                 


Gly Gly Val Tyr Pro Phe Met Trp Gly Gly Ala Gln Cys Phe Cys Asp 
625                 630                 635                 640 


Ser Glu Asn Ser Gln Met Ser Glu Ala Tyr Val Glu Leu Ser Ala Asp 
                645                 650                 655     


Cys Ala Ser Asp His Ala Gln Ala Ile Lys Val His Thr Ala Ala Met 
            660                 665                 670         


Lys Val Gly Leu Arg Ile Val Tyr Gly Asn Thr Thr Ser Phe Leu Asp 
        675                 680                 685             


Val Tyr Val Asn Gly Val Thr Pro Gly Thr Ser Lys Asp Leu Lys Val 
    690                 695                 700                 


Ile Ala Gly Pro Ile Ser Ala Ser Phe Thr Pro Phe Asp His Lys Val 
705                 710                 715                 720 


Val Ile His Arg Gly Leu Val Tyr Asn Tyr Asp Phe Pro Glu Tyr Gly 
                725                 730                 735     


Ala Met Lys Pro Gly Ala Phe Gly Asp Ile Gln Ala Thr Ser Leu Thr 
            740                 745                 750         


Ser Lys Asp Leu Ile Ala Ser Thr Asp Ile Arg Leu Leu Lys Pro Ser 
        755                 760                 765             


Ala Lys Asn Val His Val Pro Tyr Thr Gln Ala Ser Ser Gly Phe Glu 
    770                 775                 780                 


Met Trp Lys Asn Asn Ser Gly Arg Pro Leu Gln Glu Thr Ala Pro Phe 
785                 790                 795                 800 


Gly Cys Lys Ile Ala Val Asn Pro Leu Arg Ala Val Asp Cys Ser Tyr 
                805                 810                 815     


Gly Asn Ile Pro Ile Ser Ile Asp Ile Pro Asn Ala Ala Phe Ile Arg 
            820                 825                 830         


Thr Ser Asp Ala Pro Leu Val Ser Thr Val Lys Cys Glu Val Ser Glu 
        835                 840                 845             


Cys Thr Tyr Ser Ala Asp Phe Gly Gly Met Ala Thr Leu Gln Tyr Val 
    850                 855                 860                 


Ser Asp Arg Glu Gly Gln Cys Pro Val His Ser His Ser Ser Thr Ala 
865                 870                 875                 880 


Thr Leu Gln Glu Ser Thr Val His Val Leu Glu Lys Gly Ala Val Thr 
                885                 890                 895     


Val His Phe Ser Thr Ala Ser Pro Gln Ala Asn Phe Ile Val Ser Leu 
            900                 905                 910         


Cys Gly Lys Lys Thr Thr Cys Asn Ala Glu Cys Lys Pro Pro Ala Asp 
        915                 920                 925             


His Ile Val Ser Thr Pro His Lys Asn Asp Gln Glu Phe Gln Ala Ala 
    930                 935                 940                 


Ile Ser Lys Thr Ser Trp Ser Trp Leu Phe Ala Leu Phe Gly Gly Ala 
945                 950                 955                 960 


Ser Ser Leu Leu Ile Ile Gly Leu Met Ile Phe Ala Cys Ser Met Met 
                965                 970                 975     


Leu Thr Ser Thr Arg Arg 
            980         


<210>  4
<211>  982
<212>  PRT
<213>  Sindbis virus

<400>  4

Met Ser Ala Ala Pro Leu Val Thr Ala Met Cys Leu Leu Gly Asn Val 
1               5                   10                  15      


Ser Phe Pro Cys Asp Arg Pro Pro Thr Cys Tyr Thr Arg Glu Pro Ser 
            20                  25                  30          


Arg Ala Leu Asp Ile Leu Glu Glu Asn Val Asn His Glu Ala Tyr Asp 
        35                  40                  45              


Thr Leu Leu Asn Ala Ile Leu Arg Cys Gly Ser Ser Gly Arg Ser Lys 
    50                  55                  60                  


Arg Ser Val Ile Asp Asp Phe Thr Leu Thr Ser Pro Tyr Leu Gly Thr 
65                  70                  75                  80  


Cys Ser Tyr Cys His His Thr Val Pro Cys Phe Ser Pro Val Lys Ile 
                85                  90                  95      


Glu Gln Val Trp Asp Glu Ala Asp Asp Asn Thr Ile Arg Ile Gln Thr 
            100                 105                 110         


Ser Ala Gln Phe Gly Tyr Asp Gln Ser Gly Ala Ala Ser Ala Asn Lys 
        115                 120                 125             


Tyr Arg Tyr Met Ser Leu Glu Gln Asp His Thr Val Glu Glu Gly Thr 
    130                 135                 140                 


Met Asp Asp Ile Lys Ile Ser Thr Ser Gly Pro Cys Arg Arg Leu Ser 
145                 150                 155                 160 


Tyr Lys Gly Tyr Phe Leu Leu Ala Lys Cys Pro Pro Gly Asp Ser Val 
                165                 170                 175     


Thr Val Ser Ile Val Ser Ser Asn Ser Ala Thr Ser Cys Thr Leu Ala 
            180                 185                 190         


Arg Lys Ile Lys Pro Lys Phe Val Gly Arg Glu Lys Tyr Asp Leu Pro 
        195                 200                 205             


Pro Val His Gly Lys Lys Ile Pro Cys Thr Val Tyr Asp Arg Leu Glu 
    210                 215                 220                 


Gly Thr Thr Ala Gly Tyr Ile Thr Met His Arg Pro Arg Pro His Ala 
225                 230                 235                 240 


Tyr Thr Ser Tyr Leu Glu Glu Ser Ser Gly Lys Val Tyr Ala Lys Pro 
                245                 250                 255     


Pro Ser Gly Lys Asn Ile Thr Tyr Glu Cys Lys Cys Gly Asp Tyr Lys 
            260                 265                 270         


Thr Gly Thr Val Ser Thr Arg Thr Glu Ile Thr Gly Cys Thr Ala Ile 
        275                 280                 285             


Lys Gln Cys Val Ala Tyr Lys Ser Asp Gln Thr Lys Trp Val Phe Asn 
    290                 295                 300                 


Ser Pro Asp Leu Ile Arg His Asp Asp His Thr Ala Gln Gly Lys Leu 
305                 310                 315                 320 


His Leu Pro Phe Lys Leu Ile Pro Ser Thr Cys Met Val Pro Val Ala 
                325                 330                 335     


His Ala Pro Asn Val Ile His Gly Phe Lys His Ile Ser Leu Gln Leu 
            340                 345                 350         


Asp Thr Asp His Leu Thr Leu Leu Thr Thr Arg Arg Leu Gly Ala Asn 
        355                 360                 365             


Pro Glu Pro Thr Thr Glu Trp Ile Val Gly Lys Thr Val Arg Asn Phe 
    370                 375                 380                 


Thr Val Asp Arg Asp Gly Leu Glu Tyr Ile Trp Gly Asn His Glu Pro 
385                 390                 395                 400 


Val Arg Val Tyr Ala Gln Glu Ser Ala Pro Gly Asp Pro His Gly Trp 
                405                 410                 415     


Pro His Glu Ile Val Gln His Tyr Tyr His Arg His Pro Val Tyr Thr 
            420                 425                 430         


Ile Leu Ala Val Ala Ser Ala Thr Val Ala Met Met Ile Gly Val Thr 
        435                 440                 445             


Val Ala Val Leu Cys Ala Cys Lys Ala Arg Arg Glu Cys Leu Thr Pro 
    450                 455                 460                 


Tyr Ala Leu Ala Pro Asn Ala Val Ile Pro Thr Ser Leu Ala Leu Leu 
465                 470                 475                 480 


Cys Cys Val Arg Ser Ala Asn Ala Glu Thr Phe Thr Glu Thr Met Ser 
                485                 490                 495     


Tyr Leu Trp Ser Asn Ser Gln Pro Phe Phe Trp Val Gln Leu Cys Ile 
            500                 505                 510         


Pro Leu Ala Ala Phe Ile Val Leu Met Arg Cys Cys Ser Cys Cys Leu 
        515                 520                 525             


Pro Phe Leu Val Val Ala Gly Ala Tyr Leu Ala Lys Val Asp Ala Tyr 
    530                 535                 540                 


Glu His Ala Thr Thr Val Pro Asn Val Pro Gln Ile Pro Tyr Lys Ala 
545                 550                 555                 560 


Leu Val Glu Arg Ala Gly Tyr Ala Pro Leu Asn Leu Glu Ile Thr Val 
                565                 570                 575     


Met Ser Ser Glu Val Leu Pro Ser Thr Asn Gln Glu Tyr Ile Thr Cys 
            580                 585                 590         


Lys Phe Thr Thr Val Val Pro Ser Pro Lys Ile Lys Cys Cys Gly Ser 
        595                 600                 605             


Leu Glu Cys Gln Pro Ala Ala His Ala Asp Tyr Thr Cys Lys Val Phe 
    610                 615                 620                 


Gly Gly Val Tyr Pro Phe Met Trp Gly Gly Ala Gln Cys Phe Cys Asp 
625                 630                 635                 640 


Ser Glu Asn Ser Gln Met Ser Glu Ala Tyr Val Glu Leu Ser Ala Asp 
                645                 650                 655     


Cys Ala Ser Asp His Ala Gln Ala Ile Lys Val His Thr Ala Ala Met 
            660                 665                 670         


Lys Val Gly Leu Arg Ile Val Tyr Gly Asn Thr Thr Ser Phe Leu Asp 
        675                 680                 685             


Val Tyr Val Asn Gly Val Thr Pro Gly Thr Ser Lys Asp Leu Lys Val 
    690                 695                 700                 


Ile Ala Gly Pro Ile Ser Ala Ser Phe Thr Pro Phe Asp His Lys Val 
705                 710                 715                 720 


Val Ile His Arg Gly Leu Val Tyr Asn Tyr Asp Phe Pro Glu Tyr Gly 
                725                 730                 735     


Ala Met Lys Pro Gly Ala Phe Gly Asp Ile Gln Ala Thr Ser Leu Thr 
            740                 745                 750         


Ser Lys Asp Leu Ile Ala Ser Thr Asp Ile Arg Leu Leu Lys Pro Ser 
        755                 760                 765             


Ala Lys Asn Val His Val Pro Tyr Thr Gln Ala Ser Ser Gly Phe Glu 
    770                 775                 780                 


Met Trp Lys Asn Asn Ser Gly Arg Pro Leu Gln Glu Thr Ala Pro Phe 
785                 790                 795                 800 


Gly Cys Lys Ile Ala Val Asn Pro Leu Arg Ala Val Asp Cys Ser Tyr 
                805                 810                 815     


Gly Asn Ile Pro Ile Ser Ile Asp Ile Pro Asn Ala Ala Phe Ile Arg 
            820                 825                 830         


Thr Ser Asp Ala Pro Leu Val Ser Thr Val Lys Cys Glu Val Ser Glu 
        835                 840                 845             


Cys Thr Tyr Ser Ala Asp Phe Gly Gly Met Ala Thr Leu Gln Tyr Val 
    850                 855                 860                 


Ser Asp Arg Glu Gly Gln Cys Pro Val His Ser His Ser Ser Thr Ala 
865                 870                 875                 880 


Thr Leu Gln Glu Ser Thr Val His Val Leu Glu Lys Gly Ala Val Thr 
                885                 890                 895     


Val His Phe Ser Thr Ala Ser Pro Gln Ala Asn Phe Ile Val Ser Leu 
            900                 905                 910         


Cys Gly Lys Lys Thr Thr Cys Asn Ala Glu Cys Lys Pro Pro Ala Asp 
        915                 920                 925             


His Ile Val Ser Thr Pro His Lys Asn Asp Gln Glu Phe Gln Ala Ala 
    930                 935                 940                 


Ile Ser Lys Thr Ser Trp Ser Trp Leu Phe Ala Leu Phe Gly Gly Ala 
945                 950                 955                 960 


Ser Ser Leu Leu Ile Ile Gly Leu Met Ile Phe Ala Cys Ser Met Met 
                965                 970                 975     


Leu Thr Ser Thr Arg Arg 
            980         


<210>  5
<211>  980
<212>  PRT
<213>  Sindbis virus

<400>  5

Met Ser Ala Ala Pro Leu Val Thr Ala Met Cys Leu Leu Gly Asn Val 
1               5                   10                  15      


Ser Phe Pro Cys Asp Arg Pro Pro Thr Cys Tyr Thr Arg Glu Pro Ser 
            20                  25                  30          


Arg Ala Leu Asp Ile Leu Glu Glu Asn Val Asn His Glu Ala Tyr Asp 
        35                  40                  45              


Thr Leu Leu Asn Ala Ile Leu Arg Cys Gly Ser Ser Gly Arg Ser Lys 
    50                  55                  60                  


Arg Ser Val Ile Asp Asp Phe Thr Leu Thr Ser Pro Tyr Leu Gly Thr 
65                  70                  75                  80  


Cys Ser Tyr Cys His His Thr Val Pro Cys Phe Ser Pro Val Lys Ile 
                85                  90                  95      


Glu Gln Val Trp Asp Glu Ala Asp Asp Asn Thr Ile Arg Ile Gln Thr 
            100                 105                 110         


Ser Ala Gln Phe Gly Tyr Asp Gln Ser Gly Ala Ala Ser Ala Asn Lys 
        115                 120                 125             


Tyr Arg Tyr Met Ser Leu Glu Gln Asp His Thr Val Lys Glu Gly Thr 
    130                 135                 140                 


Met Asp Asp Ile Lys Ile Ser Thr Ser Gly Pro Cys Arg Arg Leu Ser 
145                 150                 155                 160 


Tyr Lys Gly Tyr Phe Leu Leu Ala Lys Cys Pro Pro Gly Asp Ser Val 
                165                 170                 175     


Thr Val Ser Ile Val Ser Ser Asn Ser Ala Thr Ser Cys Thr Leu Ala 
            180                 185                 190         


Arg Lys Ile Lys Pro Lys Phe Val Gly Arg Glu Lys Tyr Asp Leu Pro 
        195                 200                 205             


Pro Val His Gly Lys Lys Ile Pro Cys Thr Val Tyr Asp Arg Leu Thr 
    210                 215                 220                 


Thr Ala Gly Tyr Ile Thr Met His Arg Pro Arg Pro His Ala Tyr Thr 
225                 230                 235                 240 


Ser Tyr Leu Glu Glu Ser Ser Gly Lys Val Tyr Ala Lys Pro Pro Ser 
                245                 250                 255     


Gly Lys Asn Ile Thr Tyr Glu Cys Lys Cys Gly Asp Tyr Lys Thr Gly 
            260                 265                 270         


Thr Val Ser Thr Arg Thr Glu Ile Thr Gly Cys Thr Ala Ile Lys Gln 
        275                 280                 285             


Cys Val Ala Tyr Lys Ser Asp Gln Thr Lys Trp Val Phe Asn Ser Pro 
    290                 295                 300                 


Asp Leu Ile Arg His Asp Asp His Thr Ala Gln Gly Lys Leu His Leu 
305                 310                 315                 320 


Pro Phe Lys Leu Ile Pro Ser Thr Cys Met Val Pro Val Ala His Ala 
                325                 330                 335     


Pro Asn Val Ile His Gly Phe Lys His Ile Ser Leu Gln Leu Asp Thr 
            340                 345                 350         


Asp His Leu Thr Leu Leu Thr Thr Arg Arg Leu Gly Ala Asn Pro Glu 
        355                 360                 365             


Pro Thr Thr Glu Trp Ile Val Gly Lys Thr Val Arg Asn Phe Thr Val 
    370                 375                 380                 


Asp Arg Asp Gly Leu Glu Tyr Ile Trp Gly Asn His Glu Pro Val Arg 
385                 390                 395                 400 


Val Tyr Ala Gln Glu Ser Ala Pro Gly Asp Pro His Gly Trp Pro His 
                405                 410                 415     


Glu Ile Val Gln His Tyr Tyr His Arg His Pro Val Tyr Thr Ile Leu 
            420                 425                 430         


Ala Val Ala Ser Ala Thr Val Ala Met Met Ile Gly Val Thr Val Ala 
        435                 440                 445             


Val Leu Cys Ala Cys Lys Ala Arg Arg Glu Cys Leu Thr Pro Tyr Ala 
    450                 455                 460                 


Leu Ala Pro Asn Ala Val Ile Pro Thr Ser Leu Ala Leu Leu Cys Cys 
465                 470                 475                 480 


Val Arg Ser Ala Asn Ala Glu Thr Phe Thr Glu Thr Met Ser Tyr Leu 
                485                 490                 495     


Trp Ser Asn Ser Gln Pro Phe Phe Trp Val Gln Leu Cys Ile Pro Leu 
            500                 505                 510         


Ala Ala Phe Ile Val Leu Met Arg Cys Cys Ser Cys Cys Leu Pro Phe 
        515                 520                 525             


Leu Val Val Ala Gly Ala Tyr Leu Ala Lys Val Asp Ala Tyr Glu His 
    530                 535                 540                 


Ala Thr Thr Val Pro Asn Val Pro Gln Ile Pro Tyr Lys Ala Leu Val 
545                 550                 555                 560 


Glu Arg Ala Gly Tyr Ala Pro Leu Asn Leu Glu Ile Thr Val Met Ser 
                565                 570                 575     


Ser Glu Val Leu Pro Ser Thr Asn Gln Glu Tyr Ile Thr Cys Lys Phe 
            580                 585                 590         


Thr Thr Val Val Pro Ser Pro Lys Ile Lys Cys Cys Gly Ser Leu Glu 
        595                 600                 605             


Cys Gln Pro Ala Ala His Ala Asp Tyr Thr Cys Lys Val Phe Gly Gly 
    610                 615                 620                 


Val Tyr Pro Phe Met Trp Gly Gly Ala Gln Cys Phe Cys Asp Ser Glu 
625                 630                 635                 640 


Asn Ser Gln Met Ser Glu Ala Tyr Val Glu Leu Ser Ala Asp Cys Ala 
                645                 650                 655     


Ser Asp His Ala Gln Ala Ile Lys Val His Thr Ala Ala Met Lys Val 
            660                 665                 670         


Gly Leu Arg Ile Val Tyr Gly Asn Thr Thr Ser Phe Leu Asp Val Tyr 
        675                 680                 685             


Val Asn Gly Val Thr Pro Gly Thr Ser Lys Asp Leu Lys Val Ile Ala 
    690                 695                 700                 


Gly Pro Ile Ser Ala Ser Phe Thr Pro Phe Asp His Lys Val Val Ile 
705                 710                 715                 720 


His Arg Gly Leu Val Tyr Asn Tyr Asp Phe Pro Glu Tyr Gly Ala Met 
                725                 730                 735     


Lys Pro Gly Ala Phe Gly Asp Ile Gln Ala Thr Ser Leu Thr Ser Lys 
            740                 745                 750         


Asp Leu Ile Ala Ser Thr Asp Ile Arg Leu Leu Lys Pro Ser Ala Lys 
        755                 760                 765             


Asn Val His Val Pro Tyr Thr Gln Ala Ser Ser Gly Phe Glu Met Trp 
    770                 775                 780                 


Lys Asn Asn Ser Gly Arg Pro Leu Gln Glu Thr Ala Pro Phe Gly Cys 
785                 790                 795                 800 


Lys Ile Ala Val Asn Pro Leu Arg Ala Val Asp Cys Ser Tyr Gly Asn 
                805                 810                 815     


Ile Pro Ile Ser Ile Asp Ile Pro Asn Ala Ala Phe Ile Arg Thr Ser 
            820                 825                 830         


Asp Ala Pro Leu Val Ser Thr Val Lys Cys Glu Val Ser Glu Cys Thr 
        835                 840                 845             


Tyr Ser Ala Asp Phe Gly Gly Met Ala Thr Leu Gln Tyr Val Ser Asp 
    850                 855                 860                 


Arg Glu Gly Gln Cys Pro Val His Ser His Ser Ser Thr Ala Thr Leu 
865                 870                 875                 880 


Gln Glu Ser Thr Val His Val Leu Glu Lys Gly Ala Val Thr Val His 
                885                 890                 895     


Phe Ser Thr Ala Ser Pro Gln Ala Asn Phe Ile Val Ser Leu Cys Gly 
            900                 905                 910         


Lys Lys Thr Thr Cys Asn Ala Glu Cys Lys Pro Pro Ala Asp His Ile 
        915                 920                 925             


Val Ser Thr Pro His Lys Asn Asp Gln Glu Phe Gln Ala Ala Ile Ser 
    930                 935                 940                 


Lys Thr Ser Trp Ser Trp Leu Phe Ala Leu Phe Gly Gly Ala Ser Ser 
945                 950                 955                 960 


Leu Leu Ile Ile Gly Leu Met Ile Phe Ala Cys Ser Met Met Leu Thr 
                965                 970                 975     


Ser Thr Arg Arg 
            980 


<210>  6
<211>  981
<212>  PRT
<213>  Sindbis virus

<400>  6

Met Ser Ala Ala Pro Leu Val Thr Ala Met Cys Leu Leu Gly Asn Val 
1               5                   10                  15      


Ser Phe Pro Cys Asp Arg Pro Pro Thr Cys Tyr Thr Arg Glu Pro Ser 
            20                  25                  30          


Arg Ala Leu Asp Ile Leu Glu Glu Asn Val Asn His Glu Ala Tyr Asp 
        35                  40                  45              


Thr Leu Leu Asn Ala Ile Leu Arg Cys Gly Ser Ser Gly Arg Ser Lys 
    50                  55                  60                  


Arg Ser Val Ile Asp Asp Phe Thr Leu Thr Ser Pro Tyr Leu Gly Thr 
65                  70                  75                  80  


Cys Ser Tyr Cys His His Thr Val Pro Cys Phe Ser Pro Val Lys Ile 
                85                  90                  95      


Glu Gln Val Trp Asp Glu Ala Asp Asp Asn Thr Ile Arg Ile Gln Thr 
            100                 105                 110         


Ser Ala Gln Phe Gly Tyr Asp Gln Ser Gly Ala Ala Ser Ala Asn Lys 
        115                 120                 125             


Tyr Arg Tyr Met Ser Leu Glu Gln Asp His Thr Val Glu Glu Gly Thr 
    130                 135                 140                 


Met Asp Asp Ile Lys Ile Ser Thr Ser Gly Pro Cys Arg Arg Leu Ser 
145                 150                 155                 160 


Tyr Lys Gly Tyr Phe Leu Leu Ala Lys Cys Pro Pro Gly Asp Ser Val 
                165                 170                 175     


Thr Val Ser Ile Val Ser Ser Asn Ser Ala Thr Ser Cys Thr Leu Ala 
            180                 185                 190         


Arg Lys Ile Lys Pro Lys Phe Val Gly Arg Glu Lys Tyr Asp Leu Pro 
        195                 200                 205             


Pro Val His Gly Lys Lys Ile Pro Cys Thr Val Tyr Asp Arg Leu Glu 
    210                 215                 220                 


Thr Thr Ala Gly Tyr Ile Thr Met His Arg Pro Arg Pro His Ala Tyr 
225                 230                 235                 240 


Thr Ser Tyr Leu Glu Glu Ser Ser Gly Lys Val Tyr Ala Lys Pro Pro 
                245                 250                 255     


Ser Gly Lys Asn Ile Thr Tyr Glu Cys Lys Cys Gly Asp Tyr Lys Thr 
            260                 265                 270         


Gly Thr Val Ser Thr Arg Thr Glu Ile Thr Gly Cys Thr Ala Ile Lys 
        275                 280                 285             


Gln Cys Val Ala Tyr Lys Ser Asp Gln Thr Lys Trp Val Phe Asn Ser 
    290                 295                 300                 


Pro Asp Leu Ile Arg His Asp Asp His Thr Ala Gln Gly Lys Leu His 
305                 310                 315                 320 


Leu Pro Phe Lys Leu Ile Pro Ser Thr Cys Met Val Pro Val Ala His 
                325                 330                 335     


Ala Pro Asn Val Ile His Gly Phe Lys His Ile Ser Leu Gln Leu Asp 
            340                 345                 350         


Thr Asp His Leu Thr Leu Leu Thr Thr Arg Arg Leu Gly Ala Asn Pro 
        355                 360                 365             


Glu Pro Thr Thr Glu Trp Ile Val Gly Lys Thr Val Arg Asn Phe Thr 
    370                 375                 380                 


Val Asp Arg Asp Gly Leu Glu Tyr Ile Trp Gly Asn His Glu Pro Val 
385                 390                 395                 400 


Arg Val Tyr Ala Gln Glu Ser Ala Pro Gly Asp Pro His Gly Trp Pro 
                405                 410                 415     


His Glu Ile Val Gln His Tyr Tyr His Arg His Pro Val Tyr Thr Ile 
            420                 425                 430         


Leu Ala Val Ala Ser Ala Thr Val Ala Met Met Ile Gly Val Thr Val 
        435                 440                 445             


Ala Val Leu Cys Ala Cys Lys Ala Arg Arg Glu Cys Leu Thr Pro Tyr 
    450                 455                 460                 


Ala Leu Ala Pro Asn Ala Val Ile Pro Thr Ser Leu Ala Leu Leu Cys 
465                 470                 475                 480 


Cys Val Arg Ser Ala Asn Ala Glu Thr Phe Thr Glu Thr Met Ser Tyr 
                485                 490                 495     


Leu Trp Ser Asn Ser Gln Pro Phe Phe Trp Val Gln Leu Cys Ile Pro 
            500                 505                 510         


Leu Ala Ala Phe Ile Val Leu Met Arg Cys Cys Ser Cys Cys Leu Pro 
        515                 520                 525             


Phe Leu Val Val Ala Gly Ala Tyr Leu Ala Lys Val Asp Ala Tyr Glu 
    530                 535                 540                 


His Ala Thr Thr Val Pro Asn Val Pro Gln Ile Pro Tyr Lys Ala Leu 
545                 550                 555                 560 


Val Glu Arg Ala Gly Tyr Ala Pro Leu Asn Leu Glu Ile Thr Val Met 
                565                 570                 575     


Ser Ser Glu Val Leu Pro Ser Thr Asn Gln Glu Tyr Ile Thr Cys Lys 
            580                 585                 590         


Phe Thr Thr Val Val Pro Ser Pro Lys Ile Lys Cys Cys Gly Ser Leu 
        595                 600                 605             


Glu Cys Gln Pro Ala Ala His Ala Asp Tyr Thr Cys Lys Val Phe Gly 
    610                 615                 620                 


Gly Val Tyr Pro Phe Met Trp Gly Gly Ala Gln Cys Phe Cys Asp Ser 
625                 630                 635                 640 


Glu Asn Ser Gln Met Ser Glu Ala Tyr Val Glu Leu Ser Ala Asp Cys 
                645                 650                 655     


Ala Ser Asp His Ala Gln Ala Ile Lys Val His Thr Ala Ala Met Lys 
            660                 665                 670         


Val Gly Leu Arg Ile Val Tyr Gly Asn Thr Thr Ser Phe Leu Asp Val 
        675                 680                 685             


Tyr Val Asn Gly Val Thr Pro Gly Thr Ser Lys Asp Leu Lys Val Ile 
    690                 695                 700                 


Ala Gly Pro Ile Ser Ala Ser Phe Thr Pro Phe Asp His Lys Val Val 
705                 710                 715                 720 


Ile His Arg Gly Leu Val Tyr Asn Tyr Asp Phe Pro Glu Tyr Gly Ala 
                725                 730                 735     


Met Lys Pro Gly Ala Phe Gly Asp Ile Gln Ala Thr Ser Leu Thr Ser 
            740                 745                 750         


Lys Asp Leu Ile Ala Ser Thr Asp Ile Arg Leu Leu Lys Pro Ser Ala 
        755                 760                 765             


Lys Asn Val His Val Pro Tyr Thr Gln Ala Ser Ser Gly Phe Glu Met 
    770                 775                 780                 


Trp Lys Asn Asn Ser Gly Arg Pro Leu Gln Glu Thr Ala Pro Phe Gly 
785                 790                 795                 800 


Cys Lys Ile Ala Val Asn Pro Leu Arg Ala Val Asp Cys Ser Tyr Gly 
                805                 810                 815     


Asn Ile Pro Ile Ser Ile Asp Ile Pro Asn Ala Ala Phe Ile Arg Thr 
            820                 825                 830         


Ser Asp Ala Pro Leu Val Ser Thr Val Lys Cys Glu Val Ser Glu Cys 
        835                 840                 845             


Thr Tyr Ser Ala Asp Phe Gly Gly Met Ala Thr Leu Gln Tyr Val Ser 
    850                 855                 860                 


Asp Arg Glu Gly Gln Cys Pro Val His Ser His Ser Ser Thr Ala Thr 
865                 870                 875                 880 


Leu Gln Glu Ser Thr Val His Val Leu Glu Lys Gly Ala Val Thr Val 
                885                 890                 895     


His Phe Ser Thr Ala Ser Pro Gln Ala Asn Phe Ile Val Ser Leu Cys 
            900                 905                 910         


Gly Lys Lys Thr Thr Cys Asn Ala Glu Cys Lys Pro Pro Ala Asp His 
        915                 920                 925             


Ile Val Ser Thr Pro His Lys Asn Asp Gln Glu Phe Gln Ala Ala Ile 
    930                 935                 940                 


Ser Lys Thr Ser Trp Ser Trp Leu Phe Ala Leu Phe Gly Gly Ala Ser 
945                 950                 955                 960 


Ser Leu Leu Ile Ile Gly Leu Met Ile Phe Ala Cys Ser Met Met Leu 
                965                 970                 975     


Thr Ser Thr Arg Arg 
            980     


<210>  7
<211>  982
<212>  PRT
<213>  Sindbis virus

<400>  7

Met Ser Ala Ala Pro Leu Val Thr Ala Met Cys Leu Leu Gly Asn Val 
1               5                   10                  15      


Ser Phe Pro Cys Asp Arg Pro Pro Thr Cys Tyr Thr Arg Glu Pro Ser 
            20                  25                  30          


Arg Ala Leu Asp Ile Leu Glu Glu Asn Val Asn His Glu Ala Tyr Asp 
        35                  40                  45              


Thr Leu Leu Asn Ala Ile Leu Arg Cys Gly Ser Ser Gly Arg Ser Lys 
    50                  55                  60                  


Arg Ser Val Ile Asp Asp Phe Thr Leu Thr Ser Pro Tyr Leu Gly Thr 
65                  70                  75                  80  


Cys Ser Tyr Cys His His Thr Val Pro Cys Phe Ser Pro Val Lys Ile 
                85                  90                  95      


Glu Gln Val Trp Asp Glu Ala Asp Asp Asn Thr Ile Arg Ile Gln Thr 
            100                 105                 110         


Ser Ala Gln Phe Gly Tyr Asp Gln Ser Gly Ala Ala Ser Ala Asn Lys 
        115                 120                 125             


Tyr Arg Tyr Met Ser Leu Lys Gln Asp His Thr Val Lys Glu Gly Thr 
    130                 135                 140                 


Met Asp Asp Ile Lys Ile Ser Thr Ser Gly Pro Cys Arg Arg Leu Ser 
145                 150                 155                 160 


Tyr Lys Gly Tyr Phe Leu Leu Ala Lys Cys Pro Pro Gly Asp Ser Val 
                165                 170                 175     


Thr Val Ser Ile Val Ser Ser Asn Ser Ala Thr Ser Cys Thr Leu Ala 
            180                 185                 190         


Arg Lys Ile Lys Pro Lys Phe Val Gly Arg Glu Lys Tyr Asp Leu Pro 
        195                 200                 205             


Pro Val His Gly Lys Lys Ile Pro Cys Thr Val Tyr Asp Arg Leu Glu 
    210                 215                 220                 


Gly Thr Thr Ala Gly Tyr Ile Thr Met His Arg Pro Arg Pro His Ala 
225                 230                 235                 240 


Tyr Thr Ser Tyr Leu Glu Glu Ser Ser Gly Lys Val Tyr Ala Lys Pro 
                245                 250                 255     


Pro Ser Gly Lys Asn Ile Thr Tyr Glu Cys Lys Cys Gly Asp Tyr Lys 
            260                 265                 270         


Thr Gly Thr Val Ser Thr Arg Thr Glu Ile Thr Gly Cys Thr Ala Ile 
        275                 280                 285             


Lys Gln Cys Val Ala Tyr Lys Ser Asp Gln Thr Lys Trp Val Phe Asn 
    290                 295                 300                 


Ser Pro Asp Leu Ile Arg His Asp Asp His Thr Ala Gln Gly Lys Leu 
305                 310                 315                 320 


His Leu Pro Phe Lys Leu Ile Pro Ser Thr Cys Met Val Pro Val Ala 
                325                 330                 335     


His Ala Pro Asn Val Ile His Gly Phe Lys His Ile Ser Leu Gln Leu 
            340                 345                 350         


Asp Thr Asp His Leu Thr Leu Leu Thr Thr Arg Arg Leu Gly Ala Asn 
        355                 360                 365             


Pro Glu Pro Thr Thr Glu Trp Ile Val Gly Lys Thr Val Arg Asn Phe 
    370                 375                 380                 


Thr Val Asp Arg Asp Gly Leu Glu Tyr Ile Trp Gly Asn His Glu Pro 
385                 390                 395                 400 


Val Arg Val Tyr Ala Gln Glu Ser Ala Pro Gly Asp Pro His Gly Trp 
                405                 410                 415     


Pro His Glu Ile Val Gln His Tyr Tyr His Arg His Pro Val Tyr Thr 
            420                 425                 430         


Ile Leu Ala Val Ala Ser Ala Thr Val Ala Met Met Ile Gly Val Thr 
        435                 440                 445             


Val Ala Val Leu Cys Ala Cys Lys Ala Arg Arg Glu Cys Leu Thr Pro 
    450                 455                 460                 


Tyr Ala Leu Ala Pro Asn Ala Val Ile Pro Thr Ser Leu Ala Leu Leu 
465                 470                 475                 480 


Cys Cys Val Arg Ser Ala Asn Ala Glu Thr Phe Thr Glu Thr Met Ser 
                485                 490                 495     


Tyr Leu Trp Ser Asn Ser Gln Pro Phe Phe Trp Val Gln Leu Cys Ile 
            500                 505                 510         


Pro Leu Ala Ala Phe Ile Val Leu Met Arg Cys Cys Ser Cys Cys Leu 
        515                 520                 525             


Pro Phe Leu Val Val Ala Gly Ala Tyr Leu Ala Lys Val Asp Ala Tyr 
    530                 535                 540                 


Glu His Ala Thr Thr Val Pro Asn Val Pro Gln Ile Pro Tyr Lys Ala 
545                 550                 555                 560 


Leu Val Glu Arg Ala Gly Tyr Ala Pro Leu Asn Leu Glu Ile Thr Val 
                565                 570                 575     


Met Ser Ser Glu Val Leu Pro Ser Thr Asn Gln Glu Tyr Ile Thr Cys 
            580                 585                 590         


Lys Phe Thr Thr Val Val Pro Ser Pro Lys Ile Lys Cys Cys Gly Ser 
        595                 600                 605             


Leu Glu Cys Gln Pro Ala Ala His Ala Asp Tyr Thr Cys Lys Val Phe 
    610                 615                 620                 


Gly Gly Val Tyr Pro Phe Met Trp Gly Gly Ala Gln Cys Phe Cys Asp 
625                 630                 635                 640 


Ser Glu Asn Ser Gln Met Ser Glu Ala Tyr Val Glu Leu Ser Ala Asp 
                645                 650                 655     


Cys Ala Ser Asp His Ala Gln Ala Ile Lys Val His Thr Ala Ala Met 
            660                 665                 670         


Lys Val Gly Leu Arg Ile Val Tyr Gly Asn Thr Thr Ser Phe Leu Asp 
        675                 680                 685             


Val Tyr Val Asn Gly Val Thr Pro Gly Thr Ser Lys Asp Leu Lys Val 
    690                 695                 700                 


Ile Ala Gly Pro Ile Ser Ala Ser Phe Thr Pro Phe Asp His Lys Val 
705                 710                 715                 720 


Val Ile His Arg Gly Leu Val Tyr Asn Tyr Asp Phe Pro Glu Tyr Gly 
                725                 730                 735     


Ala Met Lys Pro Gly Ala Phe Gly Asp Ile Gln Ala Thr Ser Leu Thr 
            740                 745                 750         


Ser Lys Asp Leu Ile Ala Ser Thr Asp Ile Arg Leu Leu Lys Pro Ser 
        755                 760                 765             


Ala Lys Asn Val His Val Pro Tyr Thr Gln Ala Ser Ser Gly Phe Glu 
    770                 775                 780                 


Met Trp Lys Asn Asn Ser Gly Arg Pro Leu Gln Glu Thr Ala Pro Phe 
785                 790                 795                 800 


Gly Cys Lys Ile Ala Val Asn Pro Leu Arg Ala Val Asp Cys Ser Tyr 
                805                 810                 815     


Gly Asn Ile Pro Ile Ser Ile Asp Ile Pro Asn Ala Ala Phe Ile Arg 
            820                 825                 830         


Thr Ser Asp Ala Pro Leu Val Ser Thr Val Lys Cys Glu Val Ser Glu 
        835                 840                 845             


Cys Thr Tyr Ser Ala Asp Phe Gly Gly Met Ala Thr Leu Gln Tyr Val 
    850                 855                 860                 


Ser Asp Arg Glu Gly Gln Cys Pro Val His Ser His Ser Ser Thr Ala 
865                 870                 875                 880 


Thr Leu Gln Glu Ser Thr Val His Val Leu Glu Lys Gly Ala Val Thr 
                885                 890                 895     


Val His Phe Ser Thr Ala Ser Pro Gln Ala Asn Phe Ile Val Ser Leu 
            900                 905                 910         


Cys Gly Lys Lys Thr Thr Cys Asn Ala Glu Cys Lys Pro Pro Ala Asp 
        915                 920                 925             


His Ile Val Ser Thr Pro His Lys Asn Asp Gln Glu Phe Gln Ala Ala 
    930                 935                 940                 


Ile Ser Lys Thr Ser Trp Ser Trp Leu Phe Ala Leu Phe Gly Gly Ala 
945                 950                 955                 960 


Ser Ser Leu Leu Ile Ile Gly Leu Met Ile Phe Ala Cys Ser Met Met 
                965                 970                 975     


Leu Thr Ser Thr Arg Arg 
            980         


<210>  8
<211>  981
<212>  PRT
<213>  Sindbis virus

<400>  8

Met Ser Ala Ala Pro Leu Val Thr Ala Met Cys Leu Leu Gly Asn Val 
1               5                   10                  15      


Ser Phe Pro Cys Asp Arg Pro Pro Thr Cys Tyr Thr Arg Glu Pro Ser 
            20                  25                  30          


Arg Ala Leu Asp Ile Leu Glu Glu Asn Val Asn His Glu Ala Tyr Asp 
        35                  40                  45              


Thr Leu Leu Asn Ala Ile Leu Arg Cys Gly Ser Ser Gly Arg Ser Lys 
    50                  55                  60                  


Arg Ser Val Ile Asp Asp Phe Thr Leu Thr Ser Pro Tyr Leu Gly Thr 
65                  70                  75                  80  


Cys Ser Tyr Cys His His Thr Val Pro Cys Phe Ser Pro Val Lys Ile 
                85                  90                  95      


Glu Gln Val Trp Asp Glu Ala Asp Asp Asn Thr Ile Arg Ile Gln Thr 
            100                 105                 110         


Ser Ala Gln Phe Gly Tyr Asp Gln Ser Gly Ala Ala Ser Ala Asn Lys 
        115                 120                 125             


Tyr Arg Tyr Met Ser Leu Lys Gln Asp His Thr Val Lys Glu Gly Thr 
    130                 135                 140                 


Met Asp Asp Ile Lys Ile Ser Thr Ser Gly Pro Cys Arg Arg Leu Ser 
145                 150                 155                 160 


Tyr Lys Gly Tyr Phe Leu Leu Ala Lys Cys Pro Pro Gly Asp Ser Val 
                165                 170                 175     


Thr Val Ser Ile Val Ser Ser Asn Ser Ala Thr Ser Cys Thr Leu Ala 
            180                 185                 190         


Arg Lys Ile Lys Pro Lys Phe Val Gly Arg Glu Lys Tyr Asp Leu Pro 
        195                 200                 205             


Pro Val His Gly Lys Lys Ile Pro Cys Thr Val Tyr Asp Arg Leu Glu 
    210                 215                 220                 


Thr Thr Ala Gly Tyr Ile Thr Met His Arg Pro Arg Pro His Ala Tyr 
225                 230                 235                 240 


Thr Ser Tyr Leu Glu Glu Ser Ser Gly Lys Val Tyr Ala Lys Pro Pro 
                245                 250                 255     


Ser Gly Lys Asn Ile Thr Tyr Glu Cys Lys Cys Gly Asp Tyr Lys Thr 
            260                 265                 270         


Gly Thr Val Ser Thr Arg Thr Glu Ile Thr Gly Cys Thr Ala Ile Lys 
        275                 280                 285             


Gln Cys Val Ala Tyr Lys Ser Asp Gln Thr Lys Trp Val Phe Asn Ser 
    290                 295                 300                 


Pro Asp Leu Ile Arg His Asp Asp His Thr Ala Gln Gly Lys Leu His 
305                 310                 315                 320 


Leu Pro Phe Lys Leu Ile Pro Ser Thr Cys Met Val Pro Val Ala His 
                325                 330                 335     


Ala Pro Asn Val Ile His Gly Phe Lys His Ile Ser Leu Gln Leu Asp 
            340                 345                 350         


Thr Asp His Leu Thr Leu Leu Thr Thr Arg Arg Leu Gly Ala Asn Pro 
        355                 360                 365             


Glu Pro Thr Thr Glu Trp Ile Val Gly Lys Thr Val Arg Asn Phe Thr 
    370                 375                 380                 


Val Asp Arg Asp Gly Leu Glu Tyr Ile Trp Gly Asn His Glu Pro Val 
385                 390                 395                 400 


Arg Val Tyr Ala Gln Glu Ser Ala Pro Gly Asp Pro His Gly Trp Pro 
                405                 410                 415     


His Glu Ile Val Gln His Tyr Tyr His Arg His Pro Val Tyr Thr Ile 
            420                 425                 430         


Leu Ala Val Ala Ser Ala Thr Val Ala Met Met Ile Gly Val Thr Val 
        435                 440                 445             


Ala Val Leu Cys Ala Cys Lys Ala Arg Arg Glu Cys Leu Thr Pro Tyr 
    450                 455                 460                 


Ala Leu Ala Pro Asn Ala Val Ile Pro Thr Ser Leu Ala Leu Leu Cys 
465                 470                 475                 480 


Cys Val Arg Ser Ala Asn Ala Glu Thr Phe Thr Glu Thr Met Ser Tyr 
                485                 490                 495     


Leu Trp Ser Asn Ser Gln Pro Phe Phe Trp Val Gln Leu Cys Ile Pro 
            500                 505                 510         


Leu Ala Ala Phe Ile Val Leu Met Arg Cys Cys Ser Cys Cys Leu Pro 
        515                 520                 525             


Phe Leu Val Val Ala Gly Ala Tyr Leu Ala Lys Val Asp Ala Tyr Glu 
    530                 535                 540                 


His Ala Thr Thr Val Pro Asn Val Pro Gln Ile Pro Tyr Lys Ala Leu 
545                 550                 555                 560 


Val Glu Arg Ala Gly Tyr Ala Pro Leu Asn Leu Glu Ile Thr Val Met 
                565                 570                 575     


Ser Ser Glu Val Leu Pro Ser Thr Asn Gln Glu Tyr Ile Thr Cys Lys 
            580                 585                 590         


Phe Thr Thr Val Val Pro Ser Pro Lys Ile Lys Cys Cys Gly Ser Leu 
        595                 600                 605             


Glu Cys Gln Pro Ala Ala His Ala Asp Tyr Thr Cys Lys Val Phe Gly 
    610                 615                 620                 


Gly Val Tyr Pro Phe Met Trp Gly Gly Ala Gln Cys Phe Cys Asp Ser 
625                 630                 635                 640 


Glu Asn Ser Gln Met Ser Glu Ala Tyr Val Glu Leu Ser Ala Asp Cys 
                645                 650                 655     


Ala Ser Asp His Ala Gln Ala Ile Lys Val His Thr Ala Ala Met Lys 
            660                 665                 670         


Val Gly Leu Arg Ile Val Tyr Gly Asn Thr Thr Ser Phe Leu Asp Val 
        675                 680                 685             


Tyr Val Asn Gly Val Thr Pro Gly Thr Ser Lys Asp Leu Lys Val Ile 
    690                 695                 700                 


Ala Gly Pro Ile Ser Ala Ser Phe Thr Pro Phe Asp His Lys Val Val 
705                 710                 715                 720 


Ile His Arg Gly Leu Val Tyr Asn Tyr Asp Phe Pro Glu Tyr Gly Ala 
                725                 730                 735     


Met Lys Pro Gly Ala Phe Gly Asp Ile Gln Ala Thr Ser Leu Thr Ser 
            740                 745                 750         


Lys Asp Leu Ile Ala Ser Thr Asp Ile Arg Leu Leu Lys Pro Ser Ala 
        755                 760                 765             


Lys Asn Val His Val Pro Tyr Thr Gln Ala Ser Ser Gly Phe Glu Met 
    770                 775                 780                 


Trp Lys Asn Asn Ser Gly Arg Pro Leu Gln Glu Thr Ala Pro Phe Gly 
785                 790                 795                 800 


Cys Lys Ile Ala Val Asn Pro Leu Arg Ala Val Asp Cys Ser Tyr Gly 
                805                 810                 815     


Asn Ile Pro Ile Ser Ile Asp Ile Pro Asn Ala Ala Phe Ile Arg Thr 
            820                 825                 830         


Ser Asp Ala Pro Leu Val Ser Thr Val Lys Cys Glu Val Ser Glu Cys 
        835                 840                 845             


Thr Tyr Ser Ala Asp Phe Gly Gly Met Ala Thr Leu Gln Tyr Val Ser 
    850                 855                 860                 


Asp Arg Glu Gly Gln Cys Pro Val His Ser His Ser Ser Thr Ala Thr 
865                 870                 875                 880 


Leu Gln Glu Ser Thr Val His Val Leu Glu Lys Gly Ala Val Thr Val 
                885                 890                 895     


His Phe Ser Thr Ala Ser Pro Gln Ala Asn Phe Ile Val Ser Leu Cys 
            900                 905                 910         


Gly Lys Lys Thr Thr Cys Asn Ala Glu Cys Lys Pro Pro Ala Asp His 
        915                 920                 925             


Ile Val Ser Thr Pro His Lys Asn Asp Gln Glu Phe Gln Ala Ala Ile 
    930                 935                 940                 


Ser Lys Thr Ser Trp Ser Trp Leu Phe Ala Leu Phe Gly Gly Ala Ser 
945                 950                 955                 960 


Ser Leu Leu Ile Ile Gly Leu Met Ile Phe Ala Cys Ser Met Met Leu 
                965                 970                 975     


Thr Ser Thr Arg Arg 
            980     


<210>  9
<211>  982
<212>  PRT
<213>  Sindbis virus

<400>  9

Met Ser Ala Ala Pro Leu Val Thr Ala Met Cys Leu Leu Gly Asn Val 
1               5                   10                  15      


Ser Phe Pro Cys Asp Arg Pro Pro Thr Cys Tyr Thr Arg Glu Pro Ser 
            20                  25                  30          


Arg Ala Leu Asp Ile Leu Glu Glu Asn Val Asn His Glu Ala Tyr Asp 
        35                  40                  45              


Thr Leu Leu Asn Ala Ile Leu Arg Cys Gly Ser Ser Gly Arg Ser Lys 
    50                  55                  60                  


Arg Ser Val Ile Asp Asp Phe Thr Leu Thr Ser Pro Tyr Leu Gly Thr 
65                  70                  75                  80  


Cys Ser Tyr Cys His His Thr Val Pro Cys Phe Ser Pro Val Lys Ile 
                85                  90                  95      


Glu Gln Val Trp Asp Glu Ala Asp Asp Asn Thr Ile Arg Ile Gln Thr 
            100                 105                 110         


Ser Ala Gln Phe Gly Tyr Asp Gln Ser Gly Ala Ala Ser Ala Asn Lys 
        115                 120                 125             


Tyr Arg Tyr Met Ser Leu Lys Gln Asp His Thr Val Glu Glu Gly Thr 
    130                 135                 140                 


Met Asp Asp Ile Lys Ile Ser Thr Ser Gly Pro Cys Arg Arg Leu Ser 
145                 150                 155                 160 


Tyr Lys Gly Tyr Phe Leu Leu Ala Lys Cys Pro Pro Gly Asp Ser Val 
                165                 170                 175     


Thr Val Ser Ile Val Ser Ser Asn Ser Ala Thr Ser Cys Thr Leu Ala 
            180                 185                 190         


Arg Lys Ile Lys Pro Lys Phe Val Gly Arg Glu Lys Tyr Asp Leu Pro 
        195                 200                 205             


Pro Val His Gly Lys Lys Ile Pro Cys Thr Val Tyr Asp Arg Leu Glu 
    210                 215                 220                 


Gly Thr Thr Ala Gly Tyr Ile Thr Met His Arg Pro Arg Pro His Ala 
225                 230                 235                 240 


Tyr Thr Ser Tyr Leu Glu Glu Ser Ser Gly Lys Val Tyr Ala Lys Pro 
                245                 250                 255     


Pro Ser Gly Lys Asn Ile Thr Tyr Glu Cys Lys Cys Gly Asp Tyr Lys 
            260                 265                 270         


Thr Gly Thr Val Ser Thr Arg Thr Glu Ile Thr Gly Cys Thr Ala Ile 
        275                 280                 285             


Lys Gln Cys Val Ala Tyr Lys Ser Asp Gln Thr Lys Trp Val Phe Asn 
    290                 295                 300                 


Ser Pro Asp Leu Ile Arg His Asp Asp His Thr Ala Gln Gly Lys Leu 
305                 310                 315                 320 


His Leu Pro Phe Lys Leu Ile Pro Ser Thr Cys Met Val Pro Val Ala 
                325                 330                 335     


His Ala Pro Asn Val Ile His Gly Phe Lys His Ile Ser Leu Gln Leu 
            340                 345                 350         


Asp Thr Asp His Leu Thr Leu Leu Thr Thr Arg Arg Leu Gly Ala Asn 
        355                 360                 365             


Pro Glu Pro Thr Thr Glu Trp Ile Val Gly Lys Thr Val Arg Asn Phe 
    370                 375                 380                 


Thr Val Asp Arg Asp Gly Leu Glu Tyr Ile Trp Gly Asn His Glu Pro 
385                 390                 395                 400 


Val Arg Val Tyr Ala Gln Glu Ser Ala Pro Gly Asp Pro His Gly Trp 
                405                 410                 415     


Pro His Glu Ile Val Gln His Tyr Tyr His Arg His Pro Val Tyr Thr 
            420                 425                 430         


Ile Leu Ala Val Ala Ser Ala Thr Val Ala Met Met Ile Gly Val Thr 
        435                 440                 445             


Val Ala Val Leu Cys Ala Cys Lys Ala Arg Arg Glu Cys Leu Thr Pro 
    450                 455                 460                 


Tyr Ala Leu Ala Pro Asn Ala Val Ile Pro Thr Ser Leu Ala Leu Leu 
465                 470                 475                 480 


Cys Cys Val Arg Ser Ala Asn Ala Glu Thr Phe Thr Glu Thr Met Ser 
                485                 490                 495     


Tyr Leu Trp Ser Asn Ser Gln Pro Phe Phe Trp Val Gln Leu Cys Ile 
            500                 505                 510         


Pro Leu Ala Ala Phe Ile Val Leu Met Arg Cys Cys Ser Cys Cys Leu 
        515                 520                 525             


Pro Phe Leu Val Val Ala Gly Ala Tyr Leu Ala Lys Val Asp Ala Tyr 
    530                 535                 540                 


Glu His Ala Thr Thr Val Pro Asn Val Pro Gln Ile Pro Tyr Lys Ala 
545                 550                 555                 560 


Leu Val Glu Arg Ala Gly Tyr Ala Pro Leu Asn Leu Glu Ile Thr Val 
                565                 570                 575     


Met Ser Ser Glu Val Leu Pro Ser Thr Asn Gln Glu Tyr Ile Thr Cys 
            580                 585                 590         


Lys Phe Thr Thr Val Val Pro Ser Pro Lys Ile Lys Cys Cys Gly Ser 
        595                 600                 605             


Leu Glu Cys Gln Pro Ala Ala His Ala Asp Tyr Thr Cys Lys Val Phe 
    610                 615                 620                 


Gly Gly Val Tyr Pro Phe Met Trp Gly Gly Ala Gln Cys Phe Cys Asp 
625                 630                 635                 640 


Ser Glu Asn Ser Gln Met Ser Glu Ala Tyr Val Glu Leu Ser Ala Asp 
                645                 650                 655     


Cys Ala Ser Asp His Ala Gln Ala Ile Lys Val His Thr Ala Ala Met 
            660                 665                 670         


Lys Val Gly Leu Arg Ile Val Tyr Gly Asn Thr Thr Ser Phe Leu Asp 
        675                 680                 685             


Val Tyr Val Asn Gly Val Thr Pro Gly Thr Ser Lys Asp Leu Lys Val 
    690                 695                 700                 


Ile Ala Gly Pro Ile Ser Ala Ser Phe Thr Pro Phe Asp His Lys Val 
705                 710                 715                 720 


Val Ile His Arg Gly Leu Val Tyr Asn Tyr Asp Phe Pro Glu Tyr Gly 
                725                 730                 735     


Ala Met Lys Pro Gly Ala Phe Gly Asp Ile Gln Ala Thr Ser Leu Thr 
            740                 745                 750         


Ser Lys Asp Leu Ile Ala Ser Thr Asp Ile Arg Leu Leu Lys Pro Ser 
        755                 760                 765             


Ala Lys Asn Val His Val Pro Tyr Thr Gln Ala Ser Ser Gly Phe Glu 
    770                 775                 780                 


Met Trp Lys Asn Asn Ser Gly Arg Pro Leu Gln Glu Thr Ala Pro Phe 
785                 790                 795                 800 


Gly Cys Lys Ile Ala Val Asn Pro Leu Arg Ala Val Asp Cys Ser Tyr 
                805                 810                 815     


Gly Asn Ile Pro Ile Ser Ile Asp Ile Pro Asn Ala Ala Phe Ile Arg 
            820                 825                 830         


Thr Ser Asp Ala Pro Leu Val Ser Thr Val Lys Cys Glu Val Ser Glu 
        835                 840                 845             


Cys Thr Tyr Ser Ala Asp Phe Gly Gly Met Ala Thr Leu Gln Tyr Val 
    850                 855                 860                 


Ser Asp Arg Glu Gly Gln Cys Pro Val His Ser His Ser Ser Thr Ala 
865                 870                 875                 880 


Thr Leu Gln Glu Ser Thr Val His Val Leu Glu Lys Gly Ala Val Thr 
                885                 890                 895     


Val His Phe Ser Thr Ala Ser Pro Gln Ala Asn Phe Ile Val Ser Leu 
            900                 905                 910         


Cys Gly Lys Lys Thr Thr Cys Asn Ala Glu Cys Lys Pro Pro Ala Asp 
        915                 920                 925             


His Ile Val Ser Thr Pro His Lys Asn Asp Gln Glu Phe Gln Ala Ala 
    930                 935                 940                 


Ile Ser Lys Thr Ser Trp Ser Trp Leu Phe Ala Leu Phe Gly Gly Ala 
945                 950                 955                 960 


Ser Ser Leu Leu Ile Ile Gly Leu Met Ile Phe Ala Cys Ser Met Met 
                965                 970                 975     


Leu Thr Ser Thr Arg Arg 
            980         


<210>  10
<211>  981
<212>  PRT
<213>  Sindbis virus

<400>  10

Met Ser Ala Ala Pro Leu Val Thr Ala Met Cys Leu Leu Gly Asn Val 
1               5                   10                  15      


Ser Phe Pro Cys Asp Arg Pro Pro Thr Cys Tyr Thr Arg Glu Pro Ser 
            20                  25                  30          


Arg Ala Leu Asp Ile Leu Glu Glu Asn Val Asn His Glu Ala Tyr Asp 
        35                  40                  45              


Thr Leu Leu Asn Ala Ile Leu Arg Cys Gly Ser Ser Gly Arg Ser Lys 
    50                  55                  60                  


Arg Ser Val Ile Asp Asp Phe Thr Leu Thr Ser Pro Tyr Leu Gly Thr 
65                  70                  75                  80  


Cys Ser Tyr Cys His His Thr Val Pro Cys Phe Ser Pro Val Lys Ile 
                85                  90                  95      


Glu Gln Val Trp Asp Glu Ala Asp Asp Asn Thr Ile Arg Ile Gln Thr 
            100                 105                 110         


Ser Ala Gln Phe Gly Tyr Asp Gln Ser Gly Ala Ala Ser Ala Asn Lys 
        115                 120                 125             


Tyr Arg Tyr Met Ser Leu Lys Gln Asp His Thr Val Glu Glu Gly Thr 
    130                 135                 140                 


Met Asp Asp Ile Lys Ile Ser Thr Ser Gly Pro Cys Arg Arg Leu Ser 
145                 150                 155                 160 


Tyr Lys Gly Tyr Phe Leu Leu Ala Lys Cys Pro Pro Gly Asp Ser Val 
                165                 170                 175     


Thr Val Ser Ile Val Ser Ser Asn Ser Ala Thr Ser Cys Thr Leu Ala 
            180                 185                 190         


Arg Lys Ile Lys Pro Lys Phe Val Gly Arg Glu Lys Tyr Asp Leu Pro 
        195                 200                 205             


Pro Val His Gly Lys Lys Ile Pro Cys Thr Val Tyr Asp Arg Leu Glu 
    210                 215                 220                 


Thr Thr Ala Gly Tyr Ile Thr Met His Arg Pro Arg Pro His Ala Tyr 
225                 230                 235                 240 


Thr Ser Tyr Leu Glu Glu Ser Ser Gly Lys Val Tyr Ala Lys Pro Pro 
                245                 250                 255     


Ser Gly Lys Asn Ile Thr Tyr Glu Cys Lys Cys Gly Asp Tyr Lys Thr 
            260                 265                 270         


Gly Thr Val Ser Thr Arg Thr Glu Ile Thr Gly Cys Thr Ala Ile Lys 
        275                 280                 285             


Gln Cys Val Ala Tyr Lys Ser Asp Gln Thr Lys Trp Val Phe Asn Ser 
    290                 295                 300                 


Pro Asp Leu Ile Arg His Asp Asp His Thr Ala Gln Gly Lys Leu His 
305                 310                 315                 320 


Leu Pro Phe Lys Leu Ile Pro Ser Thr Cys Met Val Pro Val Ala His 
                325                 330                 335     


Ala Pro Asn Val Ile His Gly Phe Lys His Ile Ser Leu Gln Leu Asp 
            340                 345                 350         


Thr Asp His Leu Thr Leu Leu Thr Thr Arg Arg Leu Gly Ala Asn Pro 
        355                 360                 365             


Glu Pro Thr Thr Glu Trp Ile Val Gly Lys Thr Val Arg Asn Phe Thr 
    370                 375                 380                 


Val Asp Arg Asp Gly Leu Glu Tyr Ile Trp Gly Asn His Glu Pro Val 
385                 390                 395                 400 


Arg Val Tyr Ala Gln Glu Ser Ala Pro Gly Asp Pro His Gly Trp Pro 
                405                 410                 415     


His Glu Ile Val Gln His Tyr Tyr His Arg His Pro Val Tyr Thr Ile 
            420                 425                 430         


Leu Ala Val Ala Ser Ala Thr Val Ala Met Met Ile Gly Val Thr Val 
        435                 440                 445             


Ala Val Leu Cys Ala Cys Lys Ala Arg Arg Glu Cys Leu Thr Pro Tyr 
    450                 455                 460                 


Ala Leu Ala Pro Asn Ala Val Ile Pro Thr Ser Leu Ala Leu Leu Cys 
465                 470                 475                 480 


Cys Val Arg Ser Ala Asn Ala Glu Thr Phe Thr Glu Thr Met Ser Tyr 
                485                 490                 495     


Leu Trp Ser Asn Ser Gln Pro Phe Phe Trp Val Gln Leu Cys Ile Pro 
            500                 505                 510         


Leu Ala Ala Phe Ile Val Leu Met Arg Cys Cys Ser Cys Cys Leu Pro 
        515                 520                 525             


Phe Leu Val Val Ala Gly Ala Tyr Leu Ala Lys Val Asp Ala Tyr Glu 
    530                 535                 540                 


His Ala Thr Thr Val Pro Asn Val Pro Gln Ile Pro Tyr Lys Ala Leu 
545                 550                 555                 560 


Val Glu Arg Ala Gly Tyr Ala Pro Leu Asn Leu Glu Ile Thr Val Met 
                565                 570                 575     


Ser Ser Glu Val Leu Pro Ser Thr Asn Gln Glu Tyr Ile Thr Cys Lys 
            580                 585                 590         


Phe Thr Thr Val Val Pro Ser Pro Lys Ile Lys Cys Cys Gly Ser Leu 
        595                 600                 605             


Glu Cys Gln Pro Ala Ala His Ala Asp Tyr Thr Cys Lys Val Phe Gly 
    610                 615                 620                 


Gly Val Tyr Pro Phe Met Trp Gly Gly Ala Gln Cys Phe Cys Asp Ser 
625                 630                 635                 640 


Glu Asn Ser Gln Met Ser Glu Ala Tyr Val Glu Leu Ser Ala Asp Cys 
                645                 650                 655     


Ala Ser Asp His Ala Gln Ala Ile Lys Val His Thr Ala Ala Met Lys 
            660                 665                 670         


Val Gly Leu Arg Ile Val Tyr Gly Asn Thr Thr Ser Phe Leu Asp Val 
        675                 680                 685             


Tyr Val Asn Gly Val Thr Pro Gly Thr Ser Lys Asp Leu Lys Val Ile 
    690                 695                 700                 


Ala Gly Pro Ile Ser Ala Ser Phe Thr Pro Phe Asp His Lys Val Val 
705                 710                 715                 720 


Ile His Arg Gly Leu Val Tyr Asn Tyr Asp Phe Pro Glu Tyr Gly Ala 
                725                 730                 735     


Met Lys Pro Gly Ala Phe Gly Asp Ile Gln Ala Thr Ser Leu Thr Ser 
            740                 745                 750         


Lys Asp Leu Ile Ala Ser Thr Asp Ile Arg Leu Leu Lys Pro Ser Ala 
        755                 760                 765             


Lys Asn Val His Val Pro Tyr Thr Gln Ala Ser Ser Gly Phe Glu Met 
    770                 775                 780                 


Trp Lys Asn Asn Ser Gly Arg Pro Leu Gln Glu Thr Ala Pro Phe Gly 
785                 790                 795                 800 


Cys Lys Ile Ala Val Asn Pro Leu Arg Ala Val Asp Cys Ser Tyr Gly 
                805                 810                 815     


Asn Ile Pro Ile Ser Ile Asp Ile Pro Asn Ala Ala Phe Ile Arg Thr 
            820                 825                 830         


Ser Asp Ala Pro Leu Val Ser Thr Val Lys Cys Glu Val Ser Glu Cys 
        835                 840                 845             


Thr Tyr Ser Ala Asp Phe Gly Gly Met Ala Thr Leu Gln Tyr Val Ser 
    850                 855                 860                 


Asp Arg Glu Gly Gln Cys Pro Val His Ser His Ser Ser Thr Ala Thr 
865                 870                 875                 880 


Leu Gln Glu Ser Thr Val His Val Leu Glu Lys Gly Ala Val Thr Val 
                885                 890                 895     


His Phe Ser Thr Ala Ser Pro Gln Ala Asn Phe Ile Val Ser Leu Cys 
            900                 905                 910         


Gly Lys Lys Thr Thr Cys Asn Ala Glu Cys Lys Pro Pro Ala Asp His 
        915                 920                 925             


Ile Val Ser Thr Pro His Lys Asn Asp Gln Glu Phe Gln Ala Ala Ile 
    930                 935                 940                 


Ser Lys Thr Ser Trp Ser Trp Leu Phe Ala Leu Phe Gly Gly Ala Ser 
945                 950                 955                 960 


Ser Leu Leu Ile Ile Gly Leu Met Ile Phe Ala Cys Ser Met Met Leu 
                965                 970                 975     


Thr Ser Thr Arg Arg 
            980     


<210>  11
<211>  982
<212>  PRT
<213>  Sindbis virus

<400>  11

Met Ser Ala Ala Pro Leu Val Thr Ala Met Cys Leu Leu Gly Asn Val 
1               5                   10                  15      


Ser Phe Pro Cys Asp Arg Pro Pro Thr Cys Tyr Thr Arg Glu Pro Ser 
            20                  25                  30          


Arg Ala Leu Asp Ile Leu Glu Glu Asn Val Asn His Glu Ala Tyr Asp 
        35                  40                  45              


Thr Leu Leu Asn Ala Ile Leu Arg Cys Gly Ser Ser Gly Arg Ser Lys 
    50                  55                  60                  


Arg Ser Val Ile Asp Asp Phe Thr Leu Thr Ser Pro Tyr Leu Gly Thr 
65                  70                  75                  80  


Cys Ser Tyr Cys His His Thr Val Pro Cys Phe Ser Pro Val Lys Ile 
                85                  90                  95      


Glu Gln Val Trp Asp Glu Ala Asp Asp Asn Thr Ile Arg Ile Gln Thr 
            100                 105                 110         


Ser Ala Gln Phe Gly Tyr Asp Gln Ser Gly Ala Ala Ser Ala Asn Lys 
        115                 120                 125             


Tyr Arg Tyr Met Ser Leu Lys Gln Asp His Thr Val Glu Glu Gly Thr 
    130                 135                 140                 


Met Asp Asp Ile Lys Ile Ser Thr Ser Gly Pro Cys Arg Arg Leu Ser 
145                 150                 155                 160 


Tyr Lys Gly Tyr Phe Leu Leu Ala Lys Cys Pro Pro Gly Asp Ser Val 
                165                 170                 175     


Thr Val Ser Ile Val Ser Ser Asn Ser Ala Thr Ser Cys Thr Leu Ala 
            180                 185                 190         


Arg Lys Ile Lys Pro Lys Phe Val Gly Arg Glu Lys Tyr Asp Leu Pro 
        195                 200                 205             


Pro Val His Gly Lys Lys Ile Pro Cys Thr Val Tyr Asp Arg Leu Lys 
    210                 215                 220                 


Gly Thr Thr Ala Gly Tyr Ile Thr Met His Arg Pro Arg Pro His Ala 
225                 230                 235                 240 


Tyr Thr Ser Tyr Leu Glu Glu Ser Ser Gly Lys Val Tyr Ala Lys Pro 
                245                 250                 255     


Pro Ser Gly Lys Asn Ile Thr Tyr Glu Cys Lys Cys Gly Asp Tyr Lys 
            260                 265                 270         


Thr Gly Thr Val Ser Thr Arg Thr Glu Ile Thr Gly Cys Thr Ala Ile 
        275                 280                 285             


Lys Gln Cys Val Ala Tyr Lys Ser Asp Gln Thr Lys Trp Val Phe Asn 
    290                 295                 300                 


Ser Pro Asp Leu Ile Arg His Asp Asp His Thr Ala Gln Gly Lys Leu 
305                 310                 315                 320 


His Leu Pro Phe Lys Leu Ile Pro Ser Thr Cys Met Val Pro Val Ala 
                325                 330                 335     


His Ala Pro Asn Val Ile His Gly Phe Lys His Ile Ser Leu Gln Leu 
            340                 345                 350         


Asp Thr Asp His Leu Thr Leu Leu Thr Thr Arg Arg Leu Gly Ala Asn 
        355                 360                 365             


Pro Glu Pro Thr Thr Glu Trp Ile Val Gly Lys Thr Val Arg Asn Phe 
    370                 375                 380                 


Thr Val Asp Arg Asp Gly Leu Glu Tyr Ile Trp Gly Asn His Glu Pro 
385                 390                 395                 400 


Val Arg Val Tyr Ala Gln Glu Ser Ala Pro Gly Asp Pro His Gly Trp 
                405                 410                 415     


Pro His Glu Ile Val Gln His Tyr Tyr His Arg His Pro Val Tyr Thr 
            420                 425                 430         


Ile Leu Ala Val Ala Ser Ala Thr Val Ala Met Met Ile Gly Val Thr 
        435                 440                 445             


Val Ala Val Leu Cys Ala Cys Lys Ala Arg Arg Glu Cys Leu Thr Pro 
    450                 455                 460                 


Tyr Ala Leu Ala Pro Asn Ala Val Ile Pro Thr Ser Leu Ala Leu Leu 
465                 470                 475                 480 


Cys Cys Val Arg Ser Ala Asn Ala Glu Thr Phe Thr Glu Thr Met Ser 
                485                 490                 495     


Tyr Leu Trp Ser Asn Ser Gln Pro Phe Phe Trp Val Gln Leu Cys Ile 
            500                 505                 510         


Pro Leu Ala Ala Phe Ile Val Leu Met Arg Cys Cys Ser Cys Cys Leu 
        515                 520                 525             


Pro Phe Leu Val Val Ala Gly Ala Tyr Leu Ala Lys Val Asp Ala Tyr 
    530                 535                 540                 


Glu His Ala Thr Thr Val Pro Asn Val Pro Gln Ile Pro Tyr Lys Ala 
545                 550                 555                 560 


Leu Val Glu Arg Ala Gly Tyr Ala Pro Leu Asn Leu Glu Ile Thr Val 
                565                 570                 575     


Met Ser Ser Glu Val Leu Pro Ser Thr Asn Gln Glu Tyr Ile Thr Cys 
            580                 585                 590         


Lys Phe Thr Thr Val Val Pro Ser Pro Lys Ile Lys Cys Cys Gly Ser 
        595                 600                 605             


Leu Glu Cys Gln Pro Ala Ala His Ala Asp Tyr Thr Cys Lys Val Phe 
    610                 615                 620                 


Gly Gly Val Tyr Pro Phe Met Trp Gly Gly Ala Gln Cys Phe Cys Asp 
625                 630                 635                 640 


Ser Glu Asn Ser Gln Met Ser Glu Ala Tyr Val Glu Leu Ser Ala Asp 
                645                 650                 655     


Cys Ala Ser Asp His Ala Gln Ala Ile Lys Val His Thr Ala Ala Met 
            660                 665                 670         


Lys Val Gly Leu Arg Ile Val Tyr Gly Asn Thr Thr Ser Phe Leu Asp 
        675                 680                 685             


Val Tyr Val Asn Gly Val Thr Pro Gly Thr Ser Lys Asp Leu Lys Val 
    690                 695                 700                 


Ile Ala Gly Pro Ile Ser Ala Ser Phe Thr Pro Phe Asp His Lys Val 
705                 710                 715                 720 


Val Ile His Arg Gly Leu Val Tyr Asn Tyr Asp Phe Pro Glu Tyr Gly 
                725                 730                 735     


Ala Met Lys Pro Gly Ala Phe Gly Asp Ile Gln Ala Thr Ser Leu Thr 
            740                 745                 750         


Ser Lys Asp Leu Ile Ala Ser Thr Asp Ile Arg Leu Leu Lys Pro Ser 
        755                 760                 765             


Ala Lys Asn Val His Val Pro Tyr Thr Gln Ala Ser Ser Gly Phe Glu 
    770                 775                 780                 


Met Trp Lys Asn Asn Ser Gly Arg Pro Leu Gln Glu Thr Ala Pro Phe 
785                 790                 795                 800 


Gly Cys Lys Ile Ala Val Asn Pro Leu Arg Ala Val Asp Cys Ser Tyr 
                805                 810                 815     


Gly Asn Ile Pro Ile Ser Ile Asp Ile Pro Asn Ala Ala Phe Ile Arg 
            820                 825                 830         


Thr Ser Asp Ala Pro Leu Val Ser Thr Val Lys Cys Glu Val Ser Glu 
        835                 840                 845             


Cys Thr Tyr Ser Ala Asp Phe Gly Gly Met Ala Thr Leu Gln Tyr Val 
    850                 855                 860                 


Ser Asp Arg Glu Gly Gln Cys Pro Val His Ser His Ser Ser Thr Ala 
865                 870                 875                 880 


Thr Leu Gln Glu Ser Thr Val His Val Leu Glu Lys Gly Ala Val Thr 
                885                 890                 895     


Val His Phe Ser Thr Ala Ser Pro Gln Ala Asn Phe Ile Val Ser Leu 
            900                 905                 910         


Cys Gly Lys Lys Thr Thr Cys Asn Ala Glu Cys Lys Pro Pro Ala Asp 
        915                 920                 925             


His Ile Val Ser Thr Pro His Lys Asn Asp Gln Glu Phe Gln Ala Ala 
    930                 935                 940                 


Ile Ser Lys Thr Ser Trp Ser Trp Leu Phe Ala Leu Phe Gly Gly Ala 
945                 950                 955                 960 


Ser Ser Leu Leu Ile Ile Gly Leu Met Ile Phe Ala Cys Ser Met Met 
                965                 970                 975     


Leu Thr Ser Thr Arg Arg 
            980         


<210>  12
<211>  981
<212>  PRT
<213>  Sindbis virus

<400>  12

Met Ser Ala Ala Pro Leu Val Thr Ala Met Cys Leu Leu Gly Asn Val 
1               5                   10                  15      


Ser Phe Pro Cys Asp Arg Pro Pro Thr Cys Tyr Thr Arg Glu Pro Ser 
            20                  25                  30          


Arg Ala Leu Asp Ile Leu Glu Glu Asn Val Asn His Glu Ala Tyr Asp 
        35                  40                  45              


Thr Leu Leu Asn Ala Ile Leu Arg Cys Gly Ser Ser Gly Arg Ser Lys 
    50                  55                  60                  


Arg Ser Val Ile Asp Asp Phe Thr Leu Thr Ser Pro Tyr Leu Gly Thr 
65                  70                  75                  80  


Cys Ser Tyr Cys His His Thr Val Pro Cys Phe Ser Pro Val Lys Ile 
                85                  90                  95      


Glu Gln Val Trp Asp Glu Ala Asp Asp Asn Thr Ile Arg Ile Gln Thr 
            100                 105                 110         


Ser Ala Gln Phe Gly Tyr Asp Gln Ser Gly Ala Ala Ser Ala Asn Lys 
        115                 120                 125             


Tyr Arg Tyr Met Ser Leu Lys Gln Asp His Thr Val Glu Glu Gly Thr 
    130                 135                 140                 


Met Asp Asp Ile Lys Ile Ser Thr Ser Gly Pro Cys Arg Arg Leu Ser 
145                 150                 155                 160 


Tyr Lys Gly Tyr Phe Leu Leu Ala Lys Cys Pro Pro Gly Asp Ser Val 
                165                 170                 175     


Thr Val Ser Ile Val Ser Ser Asn Ser Ala Thr Ser Cys Thr Leu Ala 
            180                 185                 190         


Arg Lys Ile Lys Pro Lys Phe Val Gly Arg Glu Lys Tyr Asp Leu Pro 
        195                 200                 205             


Pro Val His Gly Lys Lys Ile Pro Cys Thr Val Tyr Asp Arg Leu Lys 
    210                 215                 220                 


Thr Thr Ala Gly Tyr Ile Thr Met His Arg Pro Arg Pro His Ala Tyr 
225                 230                 235                 240 


Thr Ser Tyr Leu Glu Glu Ser Ser Gly Lys Val Tyr Ala Lys Pro Pro 
                245                 250                 255     


Ser Gly Lys Asn Ile Thr Tyr Glu Cys Lys Cys Gly Asp Tyr Lys Thr 
            260                 265                 270         


Gly Thr Val Ser Thr Arg Thr Glu Ile Thr Gly Cys Thr Ala Ile Lys 
        275                 280                 285             


Gln Cys Val Ala Tyr Lys Ser Asp Gln Thr Lys Trp Val Phe Asn Ser 
    290                 295                 300                 


Pro Asp Leu Ile Arg His Asp Asp His Thr Ala Gln Gly Lys Leu His 
305                 310                 315                 320 


Leu Pro Phe Lys Leu Ile Pro Ser Thr Cys Met Val Pro Val Ala His 
                325                 330                 335     


Ala Pro Asn Val Ile His Gly Phe Lys His Ile Ser Leu Gln Leu Asp 
            340                 345                 350         


Thr Asp His Leu Thr Leu Leu Thr Thr Arg Arg Leu Gly Ala Asn Pro 
        355                 360                 365             


Glu Pro Thr Thr Glu Trp Ile Val Gly Lys Thr Val Arg Asn Phe Thr 
    370                 375                 380                 


Val Asp Arg Asp Gly Leu Glu Tyr Ile Trp Gly Asn His Glu Pro Val 
385                 390                 395                 400 


Arg Val Tyr Ala Gln Glu Ser Ala Pro Gly Asp Pro His Gly Trp Pro 
                405                 410                 415     


His Glu Ile Val Gln His Tyr Tyr His Arg His Pro Val Tyr Thr Ile 
            420                 425                 430         


Leu Ala Val Ala Ser Ala Thr Val Ala Met Met Ile Gly Val Thr Val 
        435                 440                 445             


Ala Val Leu Cys Ala Cys Lys Ala Arg Arg Glu Cys Leu Thr Pro Tyr 
    450                 455                 460                 


Ala Leu Ala Pro Asn Ala Val Ile Pro Thr Ser Leu Ala Leu Leu Cys 
465                 470                 475                 480 


Cys Val Arg Ser Ala Asn Ala Glu Thr Phe Thr Glu Thr Met Ser Tyr 
                485                 490                 495     


Leu Trp Ser Asn Ser Gln Pro Phe Phe Trp Val Gln Leu Cys Ile Pro 
            500                 505                 510         


Leu Ala Ala Phe Ile Val Leu Met Arg Cys Cys Ser Cys Cys Leu Pro 
        515                 520                 525             


Phe Leu Val Val Ala Gly Ala Tyr Leu Ala Lys Val Asp Ala Tyr Glu 
    530                 535                 540                 


His Ala Thr Thr Val Pro Asn Val Pro Gln Ile Pro Tyr Lys Ala Leu 
545                 550                 555                 560 


Val Glu Arg Ala Gly Tyr Ala Pro Leu Asn Leu Glu Ile Thr Val Met 
                565                 570                 575     


Ser Ser Glu Val Leu Pro Ser Thr Asn Gln Glu Tyr Ile Thr Cys Lys 
            580                 585                 590         


Phe Thr Thr Val Val Pro Ser Pro Lys Ile Lys Cys Cys Gly Ser Leu 
        595                 600                 605             


Glu Cys Gln Pro Ala Ala His Ala Asp Tyr Thr Cys Lys Val Phe Gly 
    610                 615                 620                 


Gly Val Tyr Pro Phe Met Trp Gly Gly Ala Gln Cys Phe Cys Asp Ser 
625                 630                 635                 640 


Glu Asn Ser Gln Met Ser Glu Ala Tyr Val Glu Leu Ser Ala Asp Cys 
                645                 650                 655     


Ala Ser Asp His Ala Gln Ala Ile Lys Val His Thr Ala Ala Met Lys 
            660                 665                 670         


Val Gly Leu Arg Ile Val Tyr Gly Asn Thr Thr Ser Phe Leu Asp Val 
        675                 680                 685             


Tyr Val Asn Gly Val Thr Pro Gly Thr Ser Lys Asp Leu Lys Val Ile 
    690                 695                 700                 


Ala Gly Pro Ile Ser Ala Ser Phe Thr Pro Phe Asp His Lys Val Val 
705                 710                 715                 720 


Ile His Arg Gly Leu Val Tyr Asn Tyr Asp Phe Pro Glu Tyr Gly Ala 
                725                 730                 735     


Met Lys Pro Gly Ala Phe Gly Asp Ile Gln Ala Thr Ser Leu Thr Ser 
            740                 745                 750         


Lys Asp Leu Ile Ala Ser Thr Asp Ile Arg Leu Leu Lys Pro Ser Ala 
        755                 760                 765             


Lys Asn Val His Val Pro Tyr Thr Gln Ala Ser Ser Gly Phe Glu Met 
    770                 775                 780                 


Trp Lys Asn Asn Ser Gly Arg Pro Leu Gln Glu Thr Ala Pro Phe Gly 
785                 790                 795                 800 


Cys Lys Ile Ala Val Asn Pro Leu Arg Ala Val Asp Cys Ser Tyr Gly 
                805                 810                 815     


Asn Ile Pro Ile Ser Ile Asp Ile Pro Asn Ala Ala Phe Ile Arg Thr 
            820                 825                 830         


Ser Asp Ala Pro Leu Val Ser Thr Val Lys Cys Glu Val Ser Glu Cys 
        835                 840                 845             


Thr Tyr Ser Ala Asp Phe Gly Gly Met Ala Thr Leu Gln Tyr Val Ser 
    850                 855                 860                 


Asp Arg Glu Gly Gln Cys Pro Val His Ser His Ser Ser Thr Ala Thr 
865                 870                 875                 880 


Leu Gln Glu Ser Thr Val His Val Leu Glu Lys Gly Ala Val Thr Val 
                885                 890                 895     


His Phe Ser Thr Ala Ser Pro Gln Ala Asn Phe Ile Val Ser Leu Cys 
            900                 905                 910         


Gly Lys Lys Thr Thr Cys Asn Ala Glu Cys Lys Pro Pro Ala Asp His 
        915                 920                 925             


Ile Val Ser Thr Pro His Lys Asn Asp Gln Glu Phe Gln Ala Ala Ile 
    930                 935                 940                 


Ser Lys Thr Ser Trp Ser Trp Leu Phe Ala Leu Phe Gly Gly Ala Ser 
945                 950                 955                 960 


Ser Leu Leu Ile Ile Gly Leu Met Ile Phe Ala Cys Ser Met Met Leu 
                965                 970                 975     


Thr Ser Thr Arg Arg 
            980     


<210>  13
<211>  982
<212>  PRT
<213>  Sindbis virus

<400>  13

Met Ser Ala Ala Pro Leu Val Thr Ala Met Cys Leu Leu Gly Asn Val 
1               5                   10                  15      


Ser Phe Pro Cys Asp Arg Pro Pro Thr Cys Tyr Thr Arg Glu Pro Ser 
            20                  25                  30          


Arg Ala Leu Asp Ile Leu Glu Glu Asn Val Asn His Glu Ala Tyr Asp 
        35                  40                  45              


Thr Leu Leu Asn Ala Ile Leu Arg Cys Gly Ser Ser Gly Arg Ser Lys 
    50                  55                  60                  


Arg Ser Val Ile Asp Asp Phe Thr Leu Thr Ser Pro Tyr Leu Gly Thr 
65                  70                  75                  80  


Cys Ser Tyr Cys His His Thr Val Pro Cys Phe Ser Pro Val Lys Ile 
                85                  90                  95      


Glu Gln Val Trp Asp Glu Ala Asp Asp Asn Thr Ile Arg Ile Gln Thr 
            100                 105                 110         


Ser Ala Gln Phe Gly Tyr Asp Gln Ser Gly Ala Ala Ser Ala Asn Lys 
        115                 120                 125             


Tyr Arg Tyr Met Ser Leu Glu Gln Asp His Thr Val Lys Glu Gly Thr 
    130                 135                 140                 


Met Asp Asp Ile Lys Ile Ser Thr Ser Gly Pro Cys Arg Arg Leu Ser 
145                 150                 155                 160 


Tyr Lys Gly Tyr Phe Leu Leu Ala Lys Cys Pro Pro Gly Asp Ser Val 
                165                 170                 175     


Thr Val Ser Ile Val Ser Ser Asn Ser Ala Thr Ser Cys Thr Leu Ala 
            180                 185                 190         


Arg Lys Ile Lys Pro Lys Phe Val Gly Arg Glu Lys Tyr Asp Leu Pro 
        195                 200                 205             


Pro Val His Gly Lys Lys Ile Pro Cys Thr Val Tyr Asp Arg Leu Lys 
    210                 215                 220                 


Gly Thr Thr Ala Gly Tyr Ile Thr Met His Arg Pro Arg Pro His Ala 
225                 230                 235                 240 


Tyr Thr Ser Tyr Leu Glu Glu Ser Ser Gly Lys Val Tyr Ala Lys Pro 
                245                 250                 255     


Pro Ser Gly Lys Asn Ile Thr Tyr Glu Cys Lys Cys Gly Asp Tyr Lys 
            260                 265                 270         


Thr Gly Thr Val Ser Thr Arg Thr Glu Ile Thr Gly Cys Thr Ala Ile 
        275                 280                 285             


Lys Gln Cys Val Ala Tyr Lys Ser Asp Gln Thr Lys Trp Val Phe Asn 
    290                 295                 300                 


Ser Pro Asp Leu Ile Arg His Asp Asp His Thr Ala Gln Gly Lys Leu 
305                 310                 315                 320 


His Leu Pro Phe Lys Leu Ile Pro Ser Thr Cys Met Val Pro Val Ala 
                325                 330                 335     


His Ala Pro Asn Val Ile His Gly Phe Lys His Ile Ser Leu Gln Leu 
            340                 345                 350         


Asp Thr Asp His Leu Thr Leu Leu Thr Thr Arg Arg Leu Gly Ala Asn 
        355                 360                 365             


Pro Glu Pro Thr Thr Glu Trp Ile Val Gly Lys Thr Val Arg Asn Phe 
    370                 375                 380                 


Thr Val Asp Arg Asp Gly Leu Glu Tyr Ile Trp Gly Asn His Glu Pro 
385                 390                 395                 400 


Val Arg Val Tyr Ala Gln Glu Ser Ala Pro Gly Asp Pro His Gly Trp 
                405                 410                 415     


Pro His Glu Ile Val Gln His Tyr Tyr His Arg His Pro Val Tyr Thr 
            420                 425                 430         


Ile Leu Ala Val Ala Ser Ala Thr Val Ala Met Met Ile Gly Val Thr 
        435                 440                 445             


Val Ala Val Leu Cys Ala Cys Lys Ala Arg Arg Glu Cys Leu Thr Pro 
    450                 455                 460                 


Tyr Ala Leu Ala Pro Asn Ala Val Ile Pro Thr Ser Leu Ala Leu Leu 
465                 470                 475                 480 


Cys Cys Val Arg Ser Ala Asn Ala Glu Thr Phe Thr Glu Thr Met Ser 
                485                 490                 495     


Tyr Leu Trp Ser Asn Ser Gln Pro Phe Phe Trp Val Gln Leu Cys Ile 
            500                 505                 510         


Pro Leu Ala Ala Phe Ile Val Leu Met Arg Cys Cys Ser Cys Cys Leu 
        515                 520                 525             


Pro Phe Leu Val Val Ala Gly Ala Tyr Leu Ala Lys Val Asp Ala Tyr 
    530                 535                 540                 


Glu His Ala Thr Thr Val Pro Asn Val Pro Gln Ile Pro Tyr Lys Ala 
545                 550                 555                 560 


Leu Val Glu Arg Ala Gly Tyr Ala Pro Leu Asn Leu Glu Ile Thr Val 
                565                 570                 575     


Met Ser Ser Glu Val Leu Pro Ser Thr Asn Gln Glu Tyr Ile Thr Cys 
            580                 585                 590         


Lys Phe Thr Thr Val Val Pro Ser Pro Lys Ile Lys Cys Cys Gly Ser 
        595                 600                 605             


Leu Glu Cys Gln Pro Ala Ala His Ala Asp Tyr Thr Cys Lys Val Phe 
    610                 615                 620                 


Gly Gly Val Tyr Pro Phe Met Trp Gly Gly Ala Gln Cys Phe Cys Asp 
625                 630                 635                 640 


Ser Glu Asn Ser Gln Met Ser Glu Ala Tyr Val Glu Leu Ser Ala Asp 
                645                 650                 655     


Cys Ala Ser Asp His Ala Gln Ala Ile Lys Val His Thr Ala Ala Met 
            660                 665                 670         


Lys Val Gly Leu Arg Ile Val Tyr Gly Asn Thr Thr Ser Phe Leu Asp 
        675                 680                 685             


Val Tyr Val Asn Gly Val Thr Pro Gly Thr Ser Lys Asp Leu Lys Val 
    690                 695                 700                 


Ile Ala Gly Pro Ile Ser Ala Ser Phe Thr Pro Phe Asp His Lys Val 
705                 710                 715                 720 


Val Ile His Arg Gly Leu Val Tyr Asn Tyr Asp Phe Pro Glu Tyr Gly 
                725                 730                 735     


Ala Met Lys Pro Gly Ala Phe Gly Asp Ile Gln Ala Thr Ser Leu Thr 
            740                 745                 750         


Ser Lys Asp Leu Ile Ala Ser Thr Asp Ile Arg Leu Leu Lys Pro Ser 
        755                 760                 765             


Ala Lys Asn Val His Val Pro Tyr Thr Gln Ala Ser Ser Gly Phe Glu 
    770                 775                 780                 


Met Trp Lys Asn Asn Ser Gly Arg Pro Leu Gln Glu Thr Ala Pro Phe 
785                 790                 795                 800 


Gly Cys Lys Ile Ala Val Asn Pro Leu Arg Ala Val Asp Cys Ser Tyr 
                805                 810                 815     


Gly Asn Ile Pro Ile Ser Ile Asp Ile Pro Asn Ala Ala Phe Ile Arg 
            820                 825                 830         


Thr Ser Asp Ala Pro Leu Val Ser Thr Val Lys Cys Glu Val Ser Glu 
        835                 840                 845             


Cys Thr Tyr Ser Ala Asp Phe Gly Gly Met Ala Thr Leu Gln Tyr Val 
    850                 855                 860                 


Ser Asp Arg Glu Gly Gln Cys Pro Val His Ser His Ser Ser Thr Ala 
865                 870                 875                 880 


Thr Leu Gln Glu Ser Thr Val His Val Leu Glu Lys Gly Ala Val Thr 
                885                 890                 895     


Val His Phe Ser Thr Ala Ser Pro Gln Ala Asn Phe Ile Val Ser Leu 
            900                 905                 910         


Cys Gly Lys Lys Thr Thr Cys Asn Ala Glu Cys Lys Pro Pro Ala Asp 
        915                 920                 925             


His Ile Val Ser Thr Pro His Lys Asn Asp Gln Glu Phe Gln Ala Ala 
    930                 935                 940                 


Ile Ser Lys Thr Ser Trp Ser Trp Leu Phe Ala Leu Phe Gly Gly Ala 
945                 950                 955                 960 


Ser Ser Leu Leu Ile Ile Gly Leu Met Ile Phe Ala Cys Ser Met Met 
                965                 970                 975     


Leu Thr Ser Thr Arg Arg 
            980         


<210>  14
<211>  981
<212>  PRT
<213>  Sindbis virus

<400>  14

Met Ser Ala Ala Pro Leu Val Thr Ala Met Cys Leu Leu Gly Asn Val 
1               5                   10                  15      


Ser Phe Pro Cys Asp Arg Pro Pro Thr Cys Tyr Thr Arg Glu Pro Ser 
            20                  25                  30          


Arg Ala Leu Asp Ile Leu Glu Glu Asn Val Asn His Glu Ala Tyr Asp 
        35                  40                  45              


Thr Leu Leu Asn Ala Ile Leu Arg Cys Gly Ser Ser Gly Arg Ser Lys 
    50                  55                  60                  


Arg Ser Val Ile Asp Asp Phe Thr Leu Thr Ser Pro Tyr Leu Gly Thr 
65                  70                  75                  80  


Cys Ser Tyr Cys His His Thr Val Pro Cys Phe Ser Pro Val Lys Ile 
                85                  90                  95      


Glu Gln Val Trp Asp Glu Ala Asp Asp Asn Thr Ile Arg Ile Gln Thr 
            100                 105                 110         


Ser Ala Gln Phe Gly Tyr Asp Gln Ser Gly Ala Ala Ser Ala Asn Lys 
        115                 120                 125             


Tyr Arg Tyr Met Ser Leu Glu Gln Asp His Thr Val Lys Glu Gly Thr 
    130                 135                 140                 


Met Asp Asp Ile Lys Ile Ser Thr Ser Gly Pro Cys Arg Arg Leu Ser 
145                 150                 155                 160 


Tyr Lys Gly Tyr Phe Leu Leu Ala Lys Cys Pro Pro Gly Asp Ser Val 
                165                 170                 175     


Thr Val Ser Ile Val Ser Ser Asn Ser Ala Thr Ser Cys Thr Leu Ala 
            180                 185                 190         


Arg Lys Ile Lys Pro Lys Phe Val Gly Arg Glu Lys Tyr Asp Leu Pro 
        195                 200                 205             


Pro Val His Gly Lys Lys Ile Pro Cys Thr Val Tyr Asp Arg Leu Lys 
    210                 215                 220                 


Thr Thr Ala Gly Tyr Ile Thr Met His Arg Pro Arg Pro His Ala Tyr 
225                 230                 235                 240 


Thr Ser Tyr Leu Glu Glu Ser Ser Gly Lys Val Tyr Ala Lys Pro Pro 
                245                 250                 255     


Ser Gly Lys Asn Ile Thr Tyr Glu Cys Lys Cys Gly Asp Tyr Lys Thr 
            260                 265                 270         


Gly Thr Val Ser Thr Arg Thr Glu Ile Thr Gly Cys Thr Ala Ile Lys 
        275                 280                 285             


Gln Cys Val Ala Tyr Lys Ser Asp Gln Thr Lys Trp Val Phe Asn Ser 
    290                 295                 300                 


Pro Asp Leu Ile Arg His Asp Asp His Thr Ala Gln Gly Lys Leu His 
305                 310                 315                 320 


Leu Pro Phe Lys Leu Ile Pro Ser Thr Cys Met Val Pro Val Ala His 
                325                 330                 335     


Ala Pro Asn Val Ile His Gly Phe Lys His Ile Ser Leu Gln Leu Asp 
            340                 345                 350         


Thr Asp His Leu Thr Leu Leu Thr Thr Arg Arg Leu Gly Ala Asn Pro 
        355                 360                 365             


Glu Pro Thr Thr Glu Trp Ile Val Gly Lys Thr Val Arg Asn Phe Thr 
    370                 375                 380                 


Val Asp Arg Asp Gly Leu Glu Tyr Ile Trp Gly Asn His Glu Pro Val 
385                 390                 395                 400 


Arg Val Tyr Ala Gln Glu Ser Ala Pro Gly Asp Pro His Gly Trp Pro 
                405                 410                 415     


His Glu Ile Val Gln His Tyr Tyr His Arg His Pro Val Tyr Thr Ile 
            420                 425                 430         


Leu Ala Val Ala Ser Ala Thr Val Ala Met Met Ile Gly Val Thr Val 
        435                 440                 445             


Ala Val Leu Cys Ala Cys Lys Ala Arg Arg Glu Cys Leu Thr Pro Tyr 
    450                 455                 460                 


Ala Leu Ala Pro Asn Ala Val Ile Pro Thr Ser Leu Ala Leu Leu Cys 
465                 470                 475                 480 


Cys Val Arg Ser Ala Asn Ala Glu Thr Phe Thr Glu Thr Met Ser Tyr 
                485                 490                 495     


Leu Trp Ser Asn Ser Gln Pro Phe Phe Trp Val Gln Leu Cys Ile Pro 
            500                 505                 510         


Leu Ala Ala Phe Ile Val Leu Met Arg Cys Cys Ser Cys Cys Leu Pro 
        515                 520                 525             


Phe Leu Val Val Ala Gly Ala Tyr Leu Ala Lys Val Asp Ala Tyr Glu 
    530                 535                 540                 


His Ala Thr Thr Val Pro Asn Val Pro Gln Ile Pro Tyr Lys Ala Leu 
545                 550                 555                 560 


Val Glu Arg Ala Gly Tyr Ala Pro Leu Asn Leu Glu Ile Thr Val Met 
                565                 570                 575     


Ser Ser Glu Val Leu Pro Ser Thr Asn Gln Glu Tyr Ile Thr Cys Lys 
            580                 585                 590         


Phe Thr Thr Val Val Pro Ser Pro Lys Ile Lys Cys Cys Gly Ser Leu 
        595                 600                 605             


Glu Cys Gln Pro Ala Ala His Ala Asp Tyr Thr Cys Lys Val Phe Gly 
    610                 615                 620                 


Gly Val Tyr Pro Phe Met Trp Gly Gly Ala Gln Cys Phe Cys Asp Ser 
625                 630                 635                 640 


Glu Asn Ser Gln Met Ser Glu Ala Tyr Val Glu Leu Ser Ala Asp Cys 
                645                 650                 655     


Ala Ser Asp His Ala Gln Ala Ile Lys Val His Thr Ala Ala Met Lys 
            660                 665                 670         


Val Gly Leu Arg Ile Val Tyr Gly Asn Thr Thr Ser Phe Leu Asp Val 
        675                 680                 685             


Tyr Val Asn Gly Val Thr Pro Gly Thr Ser Lys Asp Leu Lys Val Ile 
    690                 695                 700                 


Ala Gly Pro Ile Ser Ala Ser Phe Thr Pro Phe Asp His Lys Val Val 
705                 710                 715                 720 


Ile His Arg Gly Leu Val Tyr Asn Tyr Asp Phe Pro Glu Tyr Gly Ala 
                725                 730                 735     


Met Lys Pro Gly Ala Phe Gly Asp Ile Gln Ala Thr Ser Leu Thr Ser 
            740                 745                 750         


Lys Asp Leu Ile Ala Ser Thr Asp Ile Arg Leu Leu Lys Pro Ser Ala 
        755                 760                 765             


Lys Asn Val His Val Pro Tyr Thr Gln Ala Ser Ser Gly Phe Glu Met 
    770                 775                 780                 


Trp Lys Asn Asn Ser Gly Arg Pro Leu Gln Glu Thr Ala Pro Phe Gly 
785                 790                 795                 800 


Cys Lys Ile Ala Val Asn Pro Leu Arg Ala Val Asp Cys Ser Tyr Gly 
                805                 810                 815     


Asn Ile Pro Ile Ser Ile Asp Ile Pro Asn Ala Ala Phe Ile Arg Thr 
            820                 825                 830         


Ser Asp Ala Pro Leu Val Ser Thr Val Lys Cys Glu Val Ser Glu Cys 
        835                 840                 845             


Thr Tyr Ser Ala Asp Phe Gly Gly Met Ala Thr Leu Gln Tyr Val Ser 
    850                 855                 860                 


Asp Arg Glu Gly Gln Cys Pro Val His Ser His Ser Ser Thr Ala Thr 
865                 870                 875                 880 


Leu Gln Glu Ser Thr Val His Val Leu Glu Lys Gly Ala Val Thr Val 
                885                 890                 895     


His Phe Ser Thr Ala Ser Pro Gln Ala Asn Phe Ile Val Ser Leu Cys 
            900                 905                 910         


Gly Lys Lys Thr Thr Cys Asn Ala Glu Cys Lys Pro Pro Ala Asp His 
        915                 920                 925             


Ile Val Ser Thr Pro His Lys Asn Asp Gln Glu Phe Gln Ala Ala Ile 
    930                 935                 940                 


Ser Lys Thr Ser Trp Ser Trp Leu Phe Ala Leu Phe Gly Gly Ala Ser 
945                 950                 955                 960 


Ser Leu Leu Ile Ile Gly Leu Met Ile Phe Ala Cys Ser Met Met Leu 
                965                 970                 975     


Thr Ser Thr Arg Arg 
            980     


<210>  15
<211>  982
<212>  PRT
<213>  Sindbis virus

<400>  15

Met Ser Ala Ala Pro Leu Val Thr Ala Met Cys Leu Leu Gly Asn Val 
1               5                   10                  15      


Ser Phe Pro Cys Asp Arg Pro Pro Thr Cys Tyr Thr Arg Glu Pro Ser 
            20                  25                  30          


Arg Ala Leu Asp Ile Leu Glu Glu Asn Val Asn His Glu Ala Tyr Asp 
        35                  40                  45              


Thr Leu Leu Asn Ala Ile Leu Arg Cys Gly Ser Ser Gly Arg Ser Lys 
    50                  55                  60                  


Arg Ser Val Ile Asp Asp Phe Thr Leu Thr Ser Pro Tyr Leu Gly Thr 
65                  70                  75                  80  


Cys Ser Tyr Cys His His Thr Val Pro Cys Phe Ser Pro Val Lys Ile 
                85                  90                  95      


Glu Gln Val Trp Asp Glu Ala Asp Asp Asn Thr Ile Arg Ile Gln Thr 
            100                 105                 110         


Ser Ala Gln Phe Gly Tyr Asp Gln Ser Gly Ala Ala Ser Ala Asn Lys 
        115                 120                 125             


Tyr Arg Tyr Met Ser Leu Glu Gln Asp His Thr Val Glu Glu Gly Thr 
    130                 135                 140                 


Met Asp Asp Ile Lys Ile Ser Thr Ser Gly Pro Cys Arg Arg Leu Ser 
145                 150                 155                 160 


Tyr Lys Gly Tyr Phe Leu Leu Ala Lys Cys Pro Pro Gly Asp Ser Val 
                165                 170                 175     


Thr Val Ser Ile Val Ser Ser Asn Ser Ala Thr Ser Cys Thr Leu Ala 
            180                 185                 190         


Arg Lys Ile Lys Pro Lys Phe Val Gly Arg Glu Lys Tyr Asp Leu Pro 
        195                 200                 205             


Pro Val His Gly Lys Lys Ile Pro Cys Thr Val Tyr Asp Arg Leu Lys 
    210                 215                 220                 


Gly Thr Thr Ala Gly Tyr Ile Thr Met His Arg Pro Arg Pro His Ala 
225                 230                 235                 240 


Tyr Thr Ser Tyr Leu Glu Glu Ser Ser Gly Lys Val Tyr Ala Lys Pro 
                245                 250                 255     


Pro Ser Gly Lys Asn Ile Thr Tyr Glu Cys Lys Cys Gly Asp Tyr Lys 
            260                 265                 270         


Thr Gly Thr Val Ser Thr Arg Thr Glu Ile Thr Gly Cys Thr Ala Ile 
        275                 280                 285             


Lys Gln Cys Val Ala Tyr Lys Ser Asp Gln Thr Lys Trp Val Phe Asn 
    290                 295                 300                 


Ser Pro Asp Leu Ile Arg His Asp Asp His Thr Ala Gln Gly Lys Leu 
305                 310                 315                 320 


His Leu Pro Phe Lys Leu Ile Pro Ser Thr Cys Met Val Pro Val Ala 
                325                 330                 335     


His Ala Pro Asn Val Ile His Gly Phe Lys His Ile Ser Leu Gln Leu 
            340                 345                 350         


Asp Thr Asp His Leu Thr Leu Leu Thr Thr Arg Arg Leu Gly Ala Asn 
        355                 360                 365             


Pro Glu Pro Thr Thr Glu Trp Ile Val Gly Lys Thr Val Arg Asn Phe 
    370                 375                 380                 


Thr Val Asp Arg Asp Gly Leu Glu Tyr Ile Trp Gly Asn His Glu Pro 
385                 390                 395                 400 


Val Arg Val Tyr Ala Gln Glu Ser Ala Pro Gly Asp Pro His Gly Trp 
                405                 410                 415     


Pro His Glu Ile Val Gln His Tyr Tyr His Arg His Pro Val Tyr Thr 
            420                 425                 430         


Ile Leu Ala Val Ala Ser Ala Thr Val Ala Met Met Ile Gly Val Thr 
        435                 440                 445             


Val Ala Val Leu Cys Ala Cys Lys Ala Arg Arg Glu Cys Leu Thr Pro 
    450                 455                 460                 


Tyr Ala Leu Ala Pro Asn Ala Val Ile Pro Thr Ser Leu Ala Leu Leu 
465                 470                 475                 480 


Cys Cys Val Arg Ser Ala Asn Ala Glu Thr Phe Thr Glu Thr Met Ser 
                485                 490                 495     


Tyr Leu Trp Ser Asn Ser Gln Pro Phe Phe Trp Val Gln Leu Cys Ile 
            500                 505                 510         


Pro Leu Ala Ala Phe Ile Val Leu Met Arg Cys Cys Ser Cys Cys Leu 
        515                 520                 525             


Pro Phe Leu Val Val Ala Gly Ala Tyr Leu Ala Lys Val Asp Ala Tyr 
    530                 535                 540                 


Glu His Ala Thr Thr Val Pro Asn Val Pro Gln Ile Pro Tyr Lys Ala 
545                 550                 555                 560 


Leu Val Glu Arg Ala Gly Tyr Ala Pro Leu Asn Leu Glu Ile Thr Val 
                565                 570                 575     


Met Ser Ser Glu Val Leu Pro Ser Thr Asn Gln Glu Tyr Ile Thr Cys 
            580                 585                 590         


Lys Phe Thr Thr Val Val Pro Ser Pro Lys Ile Lys Cys Cys Gly Ser 
        595                 600                 605             


Leu Glu Cys Gln Pro Ala Ala His Ala Asp Tyr Thr Cys Lys Val Phe 
    610                 615                 620                 


Gly Gly Val Tyr Pro Phe Met Trp Gly Gly Ala Gln Cys Phe Cys Asp 
625                 630                 635                 640 


Ser Glu Asn Ser Gln Met Ser Glu Ala Tyr Val Glu Leu Ser Ala Asp 
                645                 650                 655     


Cys Ala Ser Asp His Ala Gln Ala Ile Lys Val His Thr Ala Ala Met 
            660                 665                 670         


Lys Val Gly Leu Arg Ile Val Tyr Gly Asn Thr Thr Ser Phe Leu Asp 
        675                 680                 685             


Val Tyr Val Asn Gly Val Thr Pro Gly Thr Ser Lys Asp Leu Lys Val 
    690                 695                 700                 


Ile Ala Gly Pro Ile Ser Ala Ser Phe Thr Pro Phe Asp His Lys Val 
705                 710                 715                 720 


Val Ile His Arg Gly Leu Val Tyr Asn Tyr Asp Phe Pro Glu Tyr Gly 
                725                 730                 735     


Ala Met Lys Pro Gly Ala Phe Gly Asp Ile Gln Ala Thr Ser Leu Thr 
            740                 745                 750         


Ser Lys Asp Leu Ile Ala Ser Thr Asp Ile Arg Leu Leu Lys Pro Ser 
        755                 760                 765             


Ala Lys Asn Val His Val Pro Tyr Thr Gln Ala Ser Ser Gly Phe Glu 
    770                 775                 780                 


Met Trp Lys Asn Asn Ser Gly Arg Pro Leu Gln Glu Thr Ala Pro Phe 
785                 790                 795                 800 


Gly Cys Lys Ile Ala Val Asn Pro Leu Arg Ala Val Asp Cys Ser Tyr 
                805                 810                 815     


Gly Asn Ile Pro Ile Ser Ile Asp Ile Pro Asn Ala Ala Phe Ile Arg 
            820                 825                 830         


Thr Ser Asp Ala Pro Leu Val Ser Thr Val Lys Cys Glu Val Ser Glu 
        835                 840                 845             


Cys Thr Tyr Ser Ala Asp Phe Gly Gly Met Ala Thr Leu Gln Tyr Val 
    850                 855                 860                 


Ser Asp Arg Glu Gly Gln Cys Pro Val His Ser His Ser Ser Thr Ala 
865                 870                 875                 880 


Thr Leu Gln Glu Ser Thr Val His Val Leu Glu Lys Gly Ala Val Thr 
                885                 890                 895     


Val His Phe Ser Thr Ala Ser Pro Gln Ala Asn Phe Ile Val Ser Leu 
            900                 905                 910         


Cys Gly Lys Lys Thr Thr Cys Asn Ala Glu Cys Lys Pro Pro Ala Asp 
        915                 920                 925             


His Ile Val Ser Thr Pro His Lys Asn Asp Gln Glu Phe Gln Ala Ala 
    930                 935                 940                 


Ile Ser Lys Thr Ser Trp Ser Trp Leu Phe Ala Leu Phe Gly Gly Ala 
945                 950                 955                 960 


Ser Ser Leu Leu Ile Ile Gly Leu Met Ile Phe Ala Cys Ser Met Met 
                965                 970                 975     


Leu Thr Ser Thr Arg Arg 
            980         


<210>  16
<211>  981
<212>  PRT
<213>  Sindbis virus

<400>  16

Met Ser Ala Ala Pro Leu Val Thr Ala Met Cys Leu Leu Gly Asn Val 
1               5                   10                  15      


Ser Phe Pro Cys Asp Arg Pro Pro Thr Cys Tyr Thr Arg Glu Pro Ser 
            20                  25                  30          


Arg Ala Leu Asp Ile Leu Glu Glu Asn Val Asn His Glu Ala Tyr Asp 
        35                  40                  45              


Thr Leu Leu Asn Ala Ile Leu Arg Cys Gly Ser Ser Gly Arg Ser Lys 
    50                  55                  60                  


Arg Ser Val Ile Asp Asp Phe Thr Leu Thr Ser Pro Tyr Leu Gly Thr 
65                  70                  75                  80  


Cys Ser Tyr Cys His His Thr Val Pro Cys Phe Ser Pro Val Lys Ile 
                85                  90                  95      


Glu Gln Val Trp Asp Glu Ala Asp Asp Asn Thr Ile Arg Ile Gln Thr 
            100                 105                 110         


Ser Ala Gln Phe Gly Tyr Asp Gln Ser Gly Ala Ala Ser Ala Asn Lys 
        115                 120                 125             


Tyr Arg Tyr Met Ser Leu Glu Gln Asp His Thr Val Glu Glu Gly Thr 
    130                 135                 140                 


Met Asp Asp Ile Lys Ile Ser Thr Ser Gly Pro Cys Arg Arg Leu Ser 
145                 150                 155                 160 


Tyr Lys Gly Tyr Phe Leu Leu Ala Lys Cys Pro Pro Gly Asp Ser Val 
                165                 170                 175     


Thr Val Ser Ile Val Ser Ser Asn Ser Ala Thr Ser Cys Thr Leu Ala 
            180                 185                 190         


Arg Lys Ile Lys Pro Lys Phe Val Gly Arg Glu Lys Tyr Asp Leu Pro 
        195                 200                 205             


Pro Val His Gly Lys Lys Ile Pro Cys Thr Val Tyr Asp Arg Leu Lys 
    210                 215                 220                 


Thr Thr Ala Gly Tyr Ile Thr Met His Arg Pro Arg Pro His Ala Tyr 
225                 230                 235                 240 


Thr Ser Tyr Leu Glu Glu Ser Ser Gly Lys Val Tyr Ala Lys Pro Pro 
                245                 250                 255     


Ser Gly Lys Asn Ile Thr Tyr Glu Cys Lys Cys Gly Asp Tyr Lys Thr 
            260                 265                 270         


Gly Thr Val Ser Thr Arg Thr Glu Ile Thr Gly Cys Thr Ala Ile Lys 
        275                 280                 285             


Gln Cys Val Ala Tyr Lys Ser Asp Gln Thr Lys Trp Val Phe Asn Ser 
    290                 295                 300                 


Pro Asp Leu Ile Arg His Asp Asp His Thr Ala Gln Gly Lys Leu His 
305                 310                 315                 320 


Leu Pro Phe Lys Leu Ile Pro Ser Thr Cys Met Val Pro Val Ala His 
                325                 330                 335     


Ala Pro Asn Val Ile His Gly Phe Lys His Ile Ser Leu Gln Leu Asp 
            340                 345                 350         


Thr Asp His Leu Thr Leu Leu Thr Thr Arg Arg Leu Gly Ala Asn Pro 
        355                 360                 365             


Glu Pro Thr Thr Glu Trp Ile Val Gly Lys Thr Val Arg Asn Phe Thr 
    370                 375                 380                 


Val Asp Arg Asp Gly Leu Glu Tyr Ile Trp Gly Asn His Glu Pro Val 
385                 390                 395                 400 


Arg Val Tyr Ala Gln Glu Ser Ala Pro Gly Asp Pro His Gly Trp Pro 
                405                 410                 415     


His Glu Ile Val Gln His Tyr Tyr His Arg His Pro Val Tyr Thr Ile 
            420                 425                 430         


Leu Ala Val Ala Ser Ala Thr Val Ala Met Met Ile Gly Val Thr Val 
        435                 440                 445             


Ala Val Leu Cys Ala Cys Lys Ala Arg Arg Glu Cys Leu Thr Pro Tyr 
    450                 455                 460                 


Ala Leu Ala Pro Asn Ala Val Ile Pro Thr Ser Leu Ala Leu Leu Cys 
465                 470                 475                 480 


Cys Val Arg Ser Ala Asn Ala Glu Thr Phe Thr Glu Thr Met Ser Tyr 
                485                 490                 495     


Leu Trp Ser Asn Ser Gln Pro Phe Phe Trp Val Gln Leu Cys Ile Pro 
            500                 505                 510         


Leu Ala Ala Phe Ile Val Leu Met Arg Cys Cys Ser Cys Cys Leu Pro 
        515                 520                 525             


Phe Leu Val Val Ala Gly Ala Tyr Leu Ala Lys Val Asp Ala Tyr Glu 
    530                 535                 540                 


His Ala Thr Thr Val Pro Asn Val Pro Gln Ile Pro Tyr Lys Ala Leu 
545                 550                 555                 560 


Val Glu Arg Ala Gly Tyr Ala Pro Leu Asn Leu Glu Ile Thr Val Met 
                565                 570                 575     


Ser Ser Glu Val Leu Pro Ser Thr Asn Gln Glu Tyr Ile Thr Cys Lys 
            580                 585                 590         


Phe Thr Thr Val Val Pro Ser Pro Lys Ile Lys Cys Cys Gly Ser Leu 
        595                 600                 605             


Glu Cys Gln Pro Ala Ala His Ala Asp Tyr Thr Cys Lys Val Phe Gly 
    610                 615                 620                 


Gly Val Tyr Pro Phe Met Trp Gly Gly Ala Gln Cys Phe Cys Asp Ser 
625                 630                 635                 640 


Glu Asn Ser Gln Met Ser Glu Ala Tyr Val Glu Leu Ser Ala Asp Cys 
                645                 650                 655     


Ala Ser Asp His Ala Gln Ala Ile Lys Val His Thr Ala Ala Met Lys 
            660                 665                 670         


Val Gly Leu Arg Ile Val Tyr Gly Asn Thr Thr Ser Phe Leu Asp Val 
        675                 680                 685             


Tyr Val Asn Gly Val Thr Pro Gly Thr Ser Lys Asp Leu Lys Val Ile 
    690                 695                 700                 


Ala Gly Pro Ile Ser Ala Ser Phe Thr Pro Phe Asp His Lys Val Val 
705                 710                 715                 720 


Ile His Arg Gly Leu Val Tyr Asn Tyr Asp Phe Pro Glu Tyr Gly Ala 
                725                 730                 735     


Met Lys Pro Gly Ala Phe Gly Asp Ile Gln Ala Thr Ser Leu Thr Ser 
            740                 745                 750         


Lys Asp Leu Ile Ala Ser Thr Asp Ile Arg Leu Leu Lys Pro Ser Ala 
        755                 760                 765             


Lys Asn Val His Val Pro Tyr Thr Gln Ala Ser Ser Gly Phe Glu Met 
    770                 775                 780                 


Trp Lys Asn Asn Ser Gly Arg Pro Leu Gln Glu Thr Ala Pro Phe Gly 
785                 790                 795                 800 


Cys Lys Ile Ala Val Asn Pro Leu Arg Ala Val Asp Cys Ser Tyr Gly 
                805                 810                 815     


Asn Ile Pro Ile Ser Ile Asp Ile Pro Asn Ala Ala Phe Ile Arg Thr 
            820                 825                 830         


Ser Asp Ala Pro Leu Val Ser Thr Val Lys Cys Glu Val Ser Glu Cys 
        835                 840                 845             


Thr Tyr Ser Ala Asp Phe Gly Gly Met Ala Thr Leu Gln Tyr Val Ser 
    850                 855                 860                 


Asp Arg Glu Gly Gln Cys Pro Val His Ser His Ser Ser Thr Ala Thr 
865                 870                 875                 880 


Leu Gln Glu Ser Thr Val His Val Leu Glu Lys Gly Ala Val Thr Val 
                885                 890                 895     


His Phe Ser Thr Ala Ser Pro Gln Ala Asn Phe Ile Val Ser Leu Cys 
            900                 905                 910         


Gly Lys Lys Thr Thr Cys Asn Ala Glu Cys Lys Pro Pro Ala Asp His 
        915                 920                 925             


Ile Val Ser Thr Pro His Lys Asn Asp Gln Glu Phe Gln Ala Ala Ile 
    930                 935                 940                 


Ser Lys Thr Ser Trp Ser Trp Leu Phe Ala Leu Phe Gly Gly Ala Ser 
945                 950                 955                 960 


Ser Leu Leu Ile Ile Gly Leu Met Ile Phe Ala Cys Ser Met Met Leu 
                965                 970                 975     


Thr Ser Thr Arg Arg 
            980     


<210>  17
<211>  982
<212>  PRT
<213>  Sindbis virus

<400>  17

Met Ser Ala Ala Pro Leu Val Thr Ala Met Cys Leu Leu Gly Asn Val 
1               5                   10                  15      


Ser Phe Pro Cys Asp Arg Pro Pro Thr Cys Tyr Thr Arg Glu Pro Ser 
            20                  25                  30          


Arg Ala Leu Asp Ile Leu Glu Glu Asn Val Asn His Glu Ala Tyr Asp 
        35                  40                  45              


Thr Leu Leu Asn Ala Ile Leu Arg Cys Gly Ser Ser Gly Arg Ser Lys 
    50                  55                  60                  


Arg Ser Val Ile Asp Asp Phe Thr Leu Thr Ser Pro Tyr Leu Gly Thr 
65                  70                  75                  80  


Cys Ser Tyr Cys His His Thr Val Pro Cys Phe Ser Pro Val Lys Ile 
                85                  90                  95      


Glu Gln Val Trp Asp Glu Ala Asp Asp Asn Thr Ile Arg Ile Gln Thr 
            100                 105                 110         


Ser Ala Gln Phe Gly Tyr Asp Gln Ser Gly Ala Ala Ser Ala Asn Lys 
        115                 120                 125             


Tyr Arg Tyr Met Ser Leu Lys Gln Asp His Thr Val Lys Glu Gly Thr 
    130                 135                 140                 


Met Asp Asp Ile Lys Ile Ser Thr Ser Gly Pro Cys Arg Arg Leu Ser 
145                 150                 155                 160 


Tyr Lys Gly Tyr Phe Leu Leu Ala Lys Cys Pro Pro Gly Asp Ser Val 
                165                 170                 175     


Thr Val Ser Ile Val Ser Ser Asn Ser Ala Thr Ser Cys Thr Leu Ala 
            180                 185                 190         


Arg Lys Ile Lys Pro Lys Phe Val Gly Arg Glu Lys Tyr Asp Leu Pro 
        195                 200                 205             


Pro Val His Gly Lys Lys Ile Pro Cys Thr Val Tyr Asp Arg Leu Lys 
    210                 215                 220                 


Glu Thr Thr Ala Gly Tyr Ile Thr Met His Arg Pro Arg Pro His Ala 
225                 230                 235                 240 


Tyr Thr Ser Tyr Leu Glu Glu Ser Ser Gly Lys Val Tyr Ala Lys Pro 
                245                 250                 255     


Pro Ser Gly Lys Asn Ile Thr Tyr Glu Cys Lys Cys Gly Asp Tyr Lys 
            260                 265                 270         


Thr Gly Thr Val Ser Thr Arg Thr Glu Ile Thr Gly Cys Thr Ala Ile 
        275                 280                 285             


Lys Gln Cys Val Ala Tyr Lys Ser Asp Gln Thr Lys Trp Val Phe Asn 
    290                 295                 300                 


Ser Pro Asp Leu Ile Arg His Asp Asp His Thr Ala Gln Gly Lys Leu 
305                 310                 315                 320 


His Leu Pro Phe Lys Leu Ile Pro Ser Thr Cys Met Val Pro Val Ala 
                325                 330                 335     


His Ala Pro Asn Val Ile His Gly Phe Lys His Ile Ser Leu Gln Leu 
            340                 345                 350         


Asp Thr Asp His Leu Thr Leu Leu Thr Thr Arg Arg Leu Gly Ala Asn 
        355                 360                 365             


Pro Glu Pro Thr Thr Glu Trp Ile Val Gly Lys Thr Val Arg Asn Phe 
    370                 375                 380                 


Thr Val Asp Arg Asp Gly Leu Glu Tyr Ile Trp Gly Asn His Glu Pro 
385                 390                 395                 400 


Val Arg Val Tyr Ala Gln Glu Ser Ala Pro Gly Asp Pro His Gly Trp 
                405                 410                 415     


Pro His Glu Ile Val Gln His Tyr Tyr His Arg His Pro Val Tyr Thr 
            420                 425                 430         


Ile Leu Ala Val Ala Ser Ala Thr Val Ala Met Met Ile Gly Val Thr 
        435                 440                 445             


Val Ala Val Leu Cys Ala Cys Lys Ala Arg Arg Glu Cys Leu Thr Pro 
    450                 455                 460                 


Tyr Ala Leu Ala Pro Asn Ala Val Ile Pro Thr Ser Leu Ala Leu Leu 
465                 470                 475                 480 


Cys Cys Val Arg Ser Ala Asn Ala Glu Thr Phe Thr Glu Thr Met Ser 
                485                 490                 495     


Tyr Leu Trp Ser Asn Ser Gln Pro Phe Phe Trp Val Gln Leu Cys Ile 
            500                 505                 510         


Pro Leu Ala Ala Phe Ile Val Leu Met Arg Cys Cys Ser Cys Cys Leu 
        515                 520                 525             


Pro Phe Leu Val Val Ala Gly Ala Tyr Leu Ala Lys Val Asp Ala Tyr 
    530                 535                 540                 


Glu His Ala Thr Thr Val Pro Asn Val Pro Gln Ile Pro Tyr Lys Ala 
545                 550                 555                 560 


Leu Val Glu Arg Ala Gly Tyr Ala Pro Leu Asn Leu Glu Ile Thr Val 
                565                 570                 575     


Met Ser Ser Glu Val Leu Pro Ser Thr Asn Gln Glu Tyr Ile Thr Cys 
            580                 585                 590         


Lys Phe Thr Thr Val Val Pro Ser Pro Lys Ile Lys Cys Cys Gly Ser 
        595                 600                 605             


Leu Glu Cys Gln Pro Ala Ala His Ala Asp Tyr Thr Cys Lys Val Phe 
    610                 615                 620                 


Gly Gly Val Tyr Pro Phe Met Trp Gly Gly Ala Gln Cys Phe Cys Asp 
625                 630                 635                 640 


Ser Glu Asn Ser Gln Met Ser Glu Ala Tyr Val Glu Leu Ser Ala Asp 
                645                 650                 655     


Cys Ala Ser Asp His Ala Gln Ala Ile Lys Val His Thr Ala Ala Met 
            660                 665                 670         


Lys Val Gly Leu Arg Ile Val Tyr Gly Asn Thr Thr Ser Phe Leu Asp 
        675                 680                 685             


Val Tyr Val Asn Gly Val Thr Pro Gly Thr Ser Lys Asp Leu Lys Val 
    690                 695                 700                 


Ile Ala Gly Pro Ile Ser Ala Ser Phe Thr Pro Phe Asp His Lys Val 
705                 710                 715                 720 


Val Ile His Arg Gly Leu Val Tyr Asn Tyr Asp Phe Pro Glu Tyr Gly 
                725                 730                 735     


Ala Met Lys Pro Gly Ala Phe Gly Asp Ile Gln Ala Thr Ser Leu Thr 
            740                 745                 750         


Ser Lys Asp Leu Ile Ala Ser Thr Asp Ile Arg Leu Leu Lys Pro Ser 
        755                 760                 765             


Ala Lys Asn Val His Val Pro Tyr Thr Gln Ala Ser Ser Gly Phe Glu 
    770                 775                 780                 


Met Trp Lys Asn Asn Ser Gly Arg Pro Leu Gln Glu Thr Ala Pro Phe 
785                 790                 795                 800 


Gly Cys Lys Ile Ala Val Asn Pro Leu Arg Ala Val Asp Cys Ser Tyr 
                805                 810                 815     


Gly Asn Ile Pro Ile Ser Ile Asp Ile Pro Asn Ala Ala Phe Ile Arg 
            820                 825                 830         


Thr Ser Asp Ala Pro Leu Val Ser Thr Val Lys Cys Glu Val Ser Glu 
        835                 840                 845             


Cys Thr Tyr Ser Ala Asp Phe Gly Gly Met Ala Thr Leu Gln Tyr Val 
    850                 855                 860                 


Ser Asp Arg Glu Gly Gln Cys Pro Val His Ser His Ser Ser Thr Ala 
865                 870                 875                 880 


Thr Leu Gln Glu Ser Thr Val His Val Leu Glu Lys Gly Ala Val Thr 
                885                 890                 895     


Val His Phe Ser Thr Ala Ser Pro Gln Ala Asn Phe Ile Val Ser Leu 
            900                 905                 910         


Cys Gly Lys Lys Thr Thr Cys Asn Ala Glu Cys Lys Pro Pro Ala Asp 
        915                 920                 925             


His Ile Val Ser Thr Pro His Lys Asn Asp Gln Glu Phe Gln Ala Ala 
    930                 935                 940                 


Ile Ser Lys Thr Ser Trp Ser Trp Leu Phe Ala Leu Phe Gly Gly Ala 
945                 950                 955                 960 


Ser Ser Leu Leu Ile Ile Gly Leu Met Ile Phe Ala Cys Ser Met Met 
                965                 970                 975     


Leu Thr Ser Thr Arg Arg 
            980         


<210>  18

<400>  18
000

<210>  19

<400>  19
000

<210>  20
<211>  488
<212>  PRT
<213>  Sindbis virus

<400>  20

Met Ser Ala Ala Pro Leu Val Thr Ala Met Cys Leu Leu Gly Asn Val 
1               5                   10                  15      


Ser Phe Pro Cys Asp Arg Pro Pro Thr Cys Tyr Thr Arg Glu Pro Ser 
            20                  25                  30          


Arg Ala Leu Asp Ile Leu Glu Glu Asn Val Asn His Glu Ala Tyr Asp 
        35                  40                  45              


Thr Leu Leu Asn Ala Ile Leu Arg Cys Gly Ser Ser Gly Arg Ser Lys 
    50                  55                  60                  


Arg Ser Val Ile Asp Asp Phe Thr Leu Thr Ser Pro Tyr Leu Gly Thr 
65                  70                  75                  80  


Cys Ser Tyr Cys His His Thr Val Pro Cys Phe Ser Pro Val Lys Ile 
                85                  90                  95      


Glu Gln Val Trp Asp Glu Ala Asp Asp Asn Thr Ile Arg Ile Gln Thr 
            100                 105                 110         


Ser Ala Gln Phe Gly Tyr Asp Gln Ser Gly Ala Ala Ser Ala Asn Lys 
        115                 120                 125             


Tyr Arg Tyr Met Ser Leu Lys Gln Asp His Thr Val Lys Glu Gly Thr 
    130                 135                 140                 


Met Asp Asp Ile Lys Ile Ser Thr Ser Gly Pro Cys Arg Arg Leu Ser 
145                 150                 155                 160 


Tyr Lys Gly Tyr Phe Leu Leu Ala Lys Cys Pro Pro Gly Asp Ser Val 
                165                 170                 175     


Thr Val Ser Ile Val Ser Ser Asn Ser Ala Thr Ser Cys Thr Leu Ala 
            180                 185                 190         


Arg Lys Ile Lys Pro Lys Phe Val Gly Arg Glu Lys Tyr Asp Leu Pro 
        195                 200                 205             


Pro Val His Gly Lys Lys Ile Pro Cys Thr Val Tyr Asp Arg Leu Lys 
    210                 215                 220                 


Glu Thr Thr Ala Gly Tyr Ile Thr Met His Arg Pro Arg Pro His Ala 
225                 230                 235                 240 


Tyr Thr Ser Tyr Leu Glu Glu Ser Ser Gly Lys Val Tyr Ala Lys Pro 
                245                 250                 255     


Pro Ser Gly Lys Asn Ile Thr Tyr Glu Cys Lys Cys Gly Asp Tyr Lys 
            260                 265                 270         


Thr Gly Thr Val Ser Thr Arg Thr Glu Ile Thr Gly Cys Thr Ala Ile 
        275                 280                 285             


Lys Gln Cys Val Ala Tyr Lys Ser Asp Gln Thr Lys Trp Val Phe Asn 
    290                 295                 300                 


Ser Pro Asp Leu Ile Arg His Asp Asp His Thr Ala Gln Gly Lys Leu 
305                 310                 315                 320 


His Leu Pro Phe Lys Leu Ile Pro Ser Thr Cys Met Val Pro Val Ala 
                325                 330                 335     


His Ala Pro Asn Val Ile His Gly Phe Lys His Ile Ser Leu Gln Leu 
            340                 345                 350         


Asp Thr Asp His Leu Thr Leu Leu Thr Thr Arg Arg Leu Gly Ala Asn 
        355                 360                 365             


Pro Glu Pro Thr Thr Glu Trp Ile Val Gly Lys Thr Val Arg Asn Phe 
    370                 375                 380                 


Thr Val Asp Arg Asp Gly Leu Glu Tyr Ile Trp Gly Asn His Glu Pro 
385                 390                 395                 400 


Val Arg Val Tyr Ala Gln Glu Ser Ala Pro Gly Asp Pro His Gly Trp 
                405                 410                 415     


Pro His Glu Ile Val Gln His Tyr Tyr His Arg His Pro Val Tyr Thr 
            420                 425                 430         


Ile Leu Ala Val Ala Ser Ala Thr Val Ala Met Met Ile Gly Val Thr 
        435                 440                 445             


Val Ala Val Leu Cys Ala Cys Lys Ala Arg Arg Glu Cys Leu Thr Pro 
    450                 455                 460                 


Tyr Ala Leu Ala Pro Asn Ala Val Ile Pro Thr Ser Leu Ala Leu Leu 
465                 470                 475                 480 


Cys Cys Val Arg Ser Ala Asn Ala 
                485             


<210>  21
<211>  683
<212>  DNA
<213>  Human immunodeficiency virus type 1

<400>  21
cctagaaaaa catggagcaa tcacaagtag caatacagca gctaccaatg ctgattgtgc       60

ctggctagaa gcacaagagg aggaggaggt gggttttcca gtcacacctc aggtaccttt      120

aagaccaatg acttacaagg cagctgtaga tcttagccac tttttaaaag aaaagggggg      180

actggaaggg ctaattcact cccaacgaag acaagatatc cttgatctgt ggatctacca      240

cacacaaggc tacttccctg attggcagaa ctacacacca gggccaggga tcagatatcc      300

actgaccttt ggatggtgct acaagctagt accagttgag caagagaagg tagaagaagc      360

caatgaagga gagaacaccc gcttgttaca ccctgtgagc ctgcatggga tggatgaccc      420

ggagagagaa gtattagagt ggaggtttga cagccgccta gcatttcatc acatggcccg      480

agagctgcat ccggactgta ctgggtctct ctggttagac cagatctgag cctgggagct      540

ctctggctaa ctagggaacc cactgcttaa gcctcaataa agcttgcctt gagtgcttca      600

agtagtgtgt gcccgtctgt tgtgtgactc tggtaactag agatccctca gaccctttta      660

gtcagtgtgg aaaatctcta gca                                              683


<210>  22
<211>  416
<212>  DNA
<213>  Human immunodeficiency virus type 1

<400>  22
cctagaaaaa catggagcaa tcacaagtag caatacagca gctaccaatg ctgattgtgc       60

ctggctagaa gcacaagagg aggaggaggt gggttttcca gtcacacctc aggtaccttt      120

aagaccaatg acttacaagg cagctgtaga tcttagccac tttttaaaag aaaagggggg      180

actggaaggg ctaattcact cccaacgaag acaagatctg ctttttgcct gtactgggtc      240

tctctggtta gaccagatct gagcctggga gctctctggc taactaggga acccactgct      300

taagcctcaa taaagcttgc cttgagtgct tcaagtagtg tgtgcccgtc tgttgtgtga      360

ctctggtaac tagagatccc tcagaccctt ttagtcagtg tggaaaatct ctagca          416


<210>  23
<211>  401
<212>  DNA
<213>  Human immunodeficiency virus type 1

<400>  23
cctagaaaaa catggagcaa tcacaagtag caatacagca gctaccaatg ctgattgtgc       60

ctggctagaa gcacaagagg aggaggaggt gggttttcca gtcacacctc aggtaccttt      120

aagaccaatg acttacaagg cagctgtaga tcttagccac tttttactgg aagggctaat      180

tcactcccaa cgaagacaag atctgctttt tgcctgtact gggtctctct ggttagacca      240

gatctgagcc tgggagctct ctggctaact agggaaccca ctgcttaagc ctcaataaag      300

cttgccttga gtgcttcaag tagtgtgtgc ccgtctgttg tgtgactctg gtaactagag      360

atccctcaga cccttttagt cagtgtggaa aatctctagc a                          401


<210>  24

<400>  24
000

<210>  25

<400>  25
000

<210>  26
<211>  5
<212>  PRT
<213>  Sindbis virus

<400>  26

Arg Ser Lys Arg Ser 
1               5   


<210>  27
<211>  4
<212>  PRT
<213>  Sindbis virus

<400>  27

Arg Ser Lys Arg 
1               


<210>  28

<400>  28
000

<210>  29

<400>  29
000

<210>  30

<400>  30
000

<210>  31

<400>  31
000

<210>  32

<400>  32
000

<210>  33

<400>  33
000

<210>  34

<400>  34
000

<210>  35
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  a tag peptide sequence

<400>  35

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  36
<211>  1374
<212>  PRT
<213>  Human herpesvirus 2

<400>  36

Met Ala Ala Pro Ala Arg Asp Pro Pro Gly Tyr Arg Tyr Ala Ala Ala 
1               5                   10                  15      


Ile Leu Pro Thr Gly Ser Ile Leu Ser Thr Ile Glu Val Ala Ser His 
            20                  25                  30          


Arg Arg Leu Phe Asp Phe Phe Ala Ala Val Arg Ser Asp Glu Asn Ser 
        35                  40                  45              


Leu Tyr Asp Val Glu Phe Asp Ala Leu Leu Gly Ser Tyr Cys Asn Thr 
    50                  55                  60                  


Leu Ser Leu Val Arg Phe Leu Glu Leu Gly Leu Ser Val Ala Cys Val 
65                  70                  75                  80  


Cys Thr Lys Phe Pro Glu Leu Ala Tyr Met Asn Glu Gly Arg Val Gln 
                85                  90                  95      


Phe Glu Val His Gln Pro Leu Ile Ala Arg Asp Gly Pro His Pro Val 
            100                 105                 110         


Glu Gln Pro Val His Asn Tyr Met Thr Lys Val Ile Asp Arg Arg Ala 
        115                 120                 125             


Leu Asn Ala Ala Phe Ser Leu Ala Thr Glu Ala Ile Ala Leu Leu Thr 
    130                 135                 140                 


Gly Glu Ala Leu Asp Gly Thr Gly Ile Ser Leu His Arg Gln Leu Arg 
145                 150                 155                 160 


Ala Ile Gln Gln Leu Ala Arg Asn Val Gln Ala Val Leu Gly Ala Phe 
                165                 170                 175     


Glu Arg Gly Thr Ala Asp Gln Met Leu His Val Leu Leu Glu Lys Ala 
            180                 185                 190         


Pro Pro Leu Ala Leu Leu Leu Pro Met Gln Arg Tyr Leu Asp Asn Gly 
        195                 200                 205             


Arg Leu Ala Thr Arg Val Ala Arg Ala Thr Leu Val Ala Glu Leu Lys 
    210                 215                 220                 


Arg Ser Phe Cys Asp Thr Ser Phe Phe Leu Gly Lys Ala Gly His Arg 
225                 230                 235                 240 


Arg Glu Ala Ile Glu Ala Trp Leu Val Asp Leu Thr Thr Ala Thr Gln 
                245                 250                 255     


Pro Ser Val Ala Val Pro Arg Leu Thr His Ala Asp Thr Arg Gly Arg 
            260                 265                 270         


Pro Val Asp Gly Val Leu Val Thr Thr Ala Ala Ile Lys Gln Arg Leu 
        275                 280                 285             


Leu Gln Ser Phe Leu Lys Val Glu Asp Thr Glu Ala Asp Val Pro Val 
    290                 295                 300                 


Thr Tyr Gly Glu Met Val Leu Asn Gly Ala Asn Leu Val Thr Ala Leu 
305                 310                 315                 320 


Val Met Gly Lys Ala Val Arg Ser Leu Asp Asp Val Gly Arg His Leu 
                325                 330                 335     


Leu Asp Met Gln Glu Glu Gln Leu Glu Ala Asn Arg Glu Thr Leu Asp 
            340                 345                 350         


Glu Leu Glu Ser Ala Pro Gln Thr Thr Arg Val Arg Ala Asp Leu Val 
        355                 360                 365             


Ala Ile Gly Asp Arg Leu Val Phe Leu Glu Ala Leu Glu Arg Arg Ile 
    370                 375                 380                 


Tyr Ala Ala Thr Asn Val Pro Tyr Pro Leu Val Gly Ala Met Asp Leu 
385                 390                 395                 400 


Thr Phe Val Leu Pro Leu Gly Leu Phe Asn Pro Ala Met Glu Arg Phe 
                405                 410                 415     


Ala Ala His Ala Gly Asp Leu Val Pro Ala Pro Gly His Pro Glu Pro 
            420                 425                 430         


Arg Ala Phe Pro Pro Arg Gln Leu Phe Phe Trp Gly Lys Asp His Gln 
        435                 440                 445             


Val Leu Arg Leu Ser Met Glu Asn Ala Val Gly Thr Val Cys His Pro 
    450                 455                 460                 


Ser Leu Met Asn Ile Asp Ala Ala Val Gly Gly Val Asn His Asp Pro 
465                 470                 475                 480 


Val Glu Ala Ala Asn Pro Tyr Gly Ala Tyr Val Ala Ala Pro Ala Gly 
                485                 490                 495     


Pro Gly Ala Asp Met Gln Gln Arg Phe Leu Asn Ala Trp Arg Gln Arg 
            500                 505                 510         


Leu Ala His Gly Arg Val Arg Trp Val Ala Glu Cys Gln Met Thr Ala 
        515                 520                 525             


Glu Gln Phe Met Gln Pro Asp Asn Ala Asn Leu Ala Leu Glu Leu His 
    530                 535                 540                 


Pro Ala Phe Asp Phe Phe Ala Gly Val Ala Asp Val Glu Leu Pro Gly 
545                 550                 555                 560 


Gly Glu Val Pro Pro Ala Gly Pro Gly Ala Ile Gln Ala Thr Trp Arg 
                565                 570                 575     


Val Val Asn Gly Asn Leu Pro Leu Ala Leu Cys Pro Val Ala Phe Arg 
            580                 585                 590         


Asp Ala Arg Gly Leu Glu Leu Gly Val Gly Arg His Ala Met Ala Pro 
        595                 600                 605             


Ala Thr Ile Ala Ala Val Arg Gly Ala Phe Glu Asp Arg Ser Tyr Pro 
    610                 615                 620                 


Ala Val Phe Tyr Leu Leu Gln Ala Ala Ile His Gly Asn Glu His Val 
625                 630                 635                 640 


Phe Cys Ala Leu Ala Arg Leu Val Thr Gln Cys Ile Thr Ser Tyr Trp 
                645                 650                 655     


Asn Asn Thr Arg Cys Ala Ala Phe Val Asn Asp Tyr Ser Leu Val Ser 
            660                 665                 670         


Tyr Ile Val Thr Tyr Leu Gly Gly Asp Leu Pro Glu Glu Cys Met Ala 
        675                 680                 685             


Val Tyr Arg Asp Leu Val Ala His Val Glu Ala Leu Ala Gln Leu Val 
    690                 695                 700                 


Asp Asp Phe Thr Leu Pro Gly Pro Glu Leu Gly Gly Gln Ala Gln Ala 
705                 710                 715                 720 


Glu Leu Asn His Leu Met Arg Asp Pro Ala Leu Leu Pro Pro Leu Val 
                725                 730                 735     


Trp Asp Cys Asp Gly Leu Met Arg His Ala Ala Leu Asp Arg His Arg 
            740                 745                 750         


Asp Cys Arg Ile Asp Ala Gly Gly His Glu Pro Val Tyr Ala Ala Ala 
        755                 760                 765             


Cys Asn Val Ala Thr Ala Asp Phe Asn Arg Asn Asp Gly Arg Leu Leu 
    770                 775                 780                 


His Asn Thr Gln Ala Arg Ala Ala Asp Ala Ala Asp Asp Arg Pro His 
785                 790                 795                 800 


Arg Pro Ala Asp Trp Thr Val His His Lys Ile Tyr Tyr Tyr Val Leu 
                805                 810                 815     


Val Pro Ala Phe Ser Arg Gly Arg Cys Cys Thr Ala Gly Val Arg Phe 
            820                 825                 830         


Asp Arg Val Tyr Ala Thr Leu Gln Asn Met Val Val Pro Glu Ile Ala 
        835                 840                 845             


Pro Gly Glu Glu Cys Pro Ser Asp Pro Val Thr Asp Pro Ala His Pro 
    850                 855                 860                 


Leu His Pro Ala Asn Leu Val Ala Asn Thr Val Lys Arg Met Phe His 
865                 870                 875                 880 


Asn Gly Arg Val Val Val Asp Gly Pro Ala Met Leu Thr Leu Gln Val 
                885                 890                 895     


Leu Ala His Asn Met Ala Glu Arg Thr Thr Ala Leu Leu Cys Ser Ala 
            900                 905                 910         


Ala Pro Asp Ala Gly Ala Asn Thr Ala Ser Thr Ala Asn Met Arg Ile 
        915                 920                 925             


Phe Asp Gly Ala Leu His Ala Gly Val Leu Leu Met Ala Pro Gln His 
    930                 935                 940                 


Leu Asp His Thr Ile Gln Asn Gly Glu Tyr Phe Tyr Val Leu Pro Val 
945                 950                 955                 960 


His Ala Leu Phe Ala Gly Ala Asp His Val Ala Asn Ala Pro Asn Phe 
                965                 970                 975     


Pro Pro Ala Leu Arg Asp Leu Ala Arg Asp Val Pro Leu Val Pro Pro 
            980                 985                 990         


Ala Leu Gly Ala Asn Tyr Phe Ser  Ser Ile Arg Gln Pro  Val Val Gln 
        995                 1000                 1005             


His Ala  Arg Glu Ser Ala Ala  Gly Glu Asn Ala Leu  Thr Tyr Ala 
    1010                 1015                 1020             


Leu Met  Ala Gly Tyr Phe Lys  Met Ser Pro Val Ala  Leu Tyr His 
    1025                 1030                 1035             


Gln Leu  Lys Thr Gly Leu His  Pro Gly Phe Gly Phe  Thr Val Val 
    1040                 1045                 1050             


Arg Gln  Asp Arg Phe Val Thr  Glu Asn Val Leu Phe  Ser Glu Arg 
    1055                 1060                 1065             


Ala Ser  Glu Ala Tyr Phe Leu  Gly Gln Leu Gln Val  Ala Arg His 
    1070                 1075                 1080             


Glu Thr  Gly Gly Gly Val Asn  Phe Thr Leu Thr Gln  Pro Arg Gly 
    1085                 1090                 1095             


Asn Val  Asp Leu Gly Val Gly  Tyr Thr Ala Val Ala  Ala Thr Gly 
    1100                 1105                 1110             


Thr Val  Arg Asn Pro Val Thr  Asp Met Gly Asn Leu  Pro Gln Asn 
    1115                 1120                 1125             


Phe Tyr  Leu Gly Arg Gly Ala  Pro Pro Leu Leu Asp  Asn Ala Ala 
    1130                 1135                 1140             


Ala Val  Tyr Leu Arg Asn Ala  Val Val Ala Gly Asn  Arg Leu Gly 
    1145                 1150                 1155             


Pro Ala  Gln Pro Leu Pro Val  Phe Gly Cys Ala Gln  Val Pro Arg 
    1160                 1165                 1170             


Arg Ala  Gly Met Asp His Gly  Gln Asp Ala Val Cys  Glu Phe Ile 
    1175                 1180                 1185             


Ala Thr  Pro Val Ala Thr Asp  Ile Asn Tyr Phe Arg  Arg Pro Cys 
    1190                 1195                 1200             


Asn Pro  Arg Gly Arg Ala Ala  Gly Gly Val Tyr Ala  Gly Asp Lys 
    1205                 1210                 1215             


Glu Gly  Asp Val Ile Ala Leu  Met Tyr Asp His Gly  Gln Ser Asp 
    1220                 1225                 1230             


Pro Ala  Arg Pro Phe Ala Ala  Thr Ala Asn Pro Trp  Ala Ser Gln 
    1235                 1240                 1245             


Arg Phe  Ser Tyr Gly Asp Leu  Leu Tyr Asn Gly Ala  Tyr His Leu 
    1250                 1255                 1260             


Asn Gly  Ala Ser Pro Val Leu  Ser Pro Cys Phe Lys  Phe Phe Thr 
    1265                 1270                 1275             


Ala Ala  Asp Ile Thr Ala Lys  His Arg Cys Leu Glu  Arg Leu Ile 
    1280                 1285                 1290             


Val Glu  Thr Gly Ser Ala Val  Ser Thr Ala Thr Ala  Ala Ser Asp 
    1295                 1300                 1305             


Val Gln  Phe Lys Arg Pro Pro  Gly Cys Arg Glu Leu  Val Glu Asp 
    1310                 1315                 1320             


Pro Cys  Gly Leu Phe Gln Glu  Ala Tyr Pro Ile Thr  Cys Ala Ser 
    1325                 1330                 1335             


Asp Pro  Ala Leu Leu Arg Ser  Ala Arg Asp Gly Glu  Ala His Ala 
    1340                 1345                 1350             


Arg Glu  Thr His Phe Thr Gln  Tyr Leu Ile Tyr Asp  Ala Ser Pro 
    1355                 1360                 1365             


Leu Lys  Gly Leu Ser Leu 
    1370                 


<210>  37
<211>  15
<212>  PRT
<213>  Human herpesvirus 2

<400>  37

Asn Tyr Phe Ser Ser Ile Arg Gln Pro Val Val Gln His Ala Arg 
1               5                   10                  15  


<210>  38
<211>  15
<212>  PRT
<213>  Human herpesvirus 2

<400>  38

Cys Glu Phe Ile Ala Thr Pro Val Ala Thr Asp Ile Asn Tyr Phe 
1               5                   10                  15  


<210>  39
<211>  15
<212>  PRT
<213>  Human herpesvirus 2

<400>  39

Glu Asn Ala Leu Thr Tyr Ala Leu Met Ala Gly Tyr Phe Lys Met 
1               5                   10                  15  


<210>  40
<211>  15
<212>  PRT
<213>  Human herpesvirus 2

<400>  40

His Pro Gly Phe Gly Phe Thr Val Val Arg Gln Asp Arg Phe Val 
1               5                   10                  15  


<210>  41
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  a tag peptide sequence

<400>  41

Asp Leu Tyr Asp Asp Asp Asp Lys 
1               5               


<210>  42
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  42

Gly Pro Lys Glu Pro Phe Gln Ser Tyr Val Asp Arg Phe Tyr Lys Ser 
1               5                   10                  15      


Leu Arg Ala Glu Gln Thr Asp Ala Ala Val Lys Asn Trp Met Thr Gln 
            20                  25                  30          


Thr Leu Leu Ile Gln Asn Ala Asn Pro Asp Cys Lys Leu 
        35                  40                  45  


<210>  43
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  43

Ala Ala Val Lys Asn Trp Met Thr Gln Thr Leu 
1               5                   10      


<210>  44
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  44

Lys Ser Leu Tyr Asn Thr Val Cys Val 
1               5                   


<210>  45
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  45

Asp Arg Phe Tyr Lys Ser Leu Arg Ala Glu Gln Thr Asp 
1               5                   10              


