                         SEQUENCE LISTING

<110>  DANA-FARBER CANCER INSTITUTE, INC.
 
<120>  PI3K-mTORC1-S6K1 Signaling Pathway Biomarkers Predictive Of 
       Anti-Cancer Responses

<130>  DFS-131.25

<140>  PCT/US2015/015544
<141>  2015-02-12

<150>  61/938,816
<151>  2014-02-12

<160>  46    

<170>  PatentIn version 3.5

<210>  1
<211>  525
<212>  DNA
<213>  Homo sapiens

<400>  1
gacccccgag ctgtgctgct cgcggccgcc accgccgggc cccggccgtc cctggctccc       60

ctcctgcctc gagaagggca gggcttctca gaggcttggc gggaaaaaga acggagggag      120

ggatcgcgct gagtataaaa gccggttttc ggggctttat ctaactcgct gtagtaattc      180

cagcgagagg cagagggagc gagcgggcgg ccggctaggg tggaagagcc gggcgagcag      240

agctgcgctg cgggcgtcct gggaagggag atccggagcg aatagggggc ttcgcctctg      300

gcccagccct cccgctgatc ccccagccag cggtccgcaa cccttgccgc atccacgaaa      360

ctttgcccat agcagcgggc gggcactttg cactggaact tacaacaccc gagcaaggac      420

gcgactctcc cgacgcgggg aggctattct gcccatttgg ggacacttcc ccgccgctgc      480

caggacccgc ttctctgaaa ggctctcctt gcagctgctt agacg                      525


<210>  2
<211>  626
<212>  DNA
<213>  Mus musculus

<400>  2
cccgcccacc cgccctttat attccggggg tctgcgcggc cgaggacccc tgggctgcgc       60

tgctctcagc tgccgggtcc gactcgcctc actcagctcc cctcctgcct cctgaagggc      120

agggcttcgc cgacgcttgg cgggaaaaag aagggagggg agggatcctg agtcgcagta      180

taaaagaagc ttttcgggcg tttttttctg actcgctgta gtaattccag cgagagacag      240

agggagtgag cggacggttg gaagagccgt gtgtgcagag ccgcgctccg gggcgaccta      300

agaaggcagc tctggagtga gaggggcttt gcctccgagc ctgccgccca ctctccccaa      360

ccctgcgact gacccaacat cagcggccgc aaccctcgcc gccgctggga aactttgccc      420

attgcagcgg gcagacactt ctcactggaa cttacaatct gcgagccagg acaggactcc      480

ccaggctccg gggagggaat ttttgtctat ttggggacag tgttctctgc ctctgcccgc      540

gatcagctct cctgaaaaga gctcctcgag ctgtttgaag gctggatttc ctttgggcgt      600

tggaaacccc gcagacagcc acgacg                                           626


<210>  3
<211>  536
<212>  DNA
<213>  Rattus norvegicus

<400>  3
acccccgggc tgcgctgctc tccgctgccg cctccgccgc gcccactccg ctcgcctcct       60

gcctccaaaa gggcagggct tcgccgaggc ttggcgggaa aaagaagcga ggggagggat      120

ccggagtcgc agtataaaag aagcttttcg ggcgtttttt ttctgactcg ctgtagtaat      180

tccagcgaga gacagaggga gtgagcgggc gggttggaag agcccagtgt gcagagcccc      240

actccgggct tcctaggaag gcagctctgg agtgagaagg gctttgcctc caggcttgct      300

gcctcctcga cccaatcctc ccgctgaccc aacatcagcg gtcgcaaccc tcgccgcctc      360

tgggaaactt tgcccattgc aacgggcaga cacttctcac tggaacttac aatctgcgag      420

ccaggacagg actccccagg cgcaggggag ggaatttttg tctatttggg gacagtgttc      480

tctgcctctg cccgcgatcg gctcccctga aaagagctcc tcgcgttatt tgaagc          536


<210>  4
<211>  592
<212>  DNA
<213>  Sus scrofa

<400>  4
tataggcgag ggtctgcgcg gctggggacc ctccggctgc gcatctctcg gctgccgccg       60

cctttgccgc accccggcca ccgctaggct ccccactgcc tctggaaggg cagggctata      120

cagaggcttg gcgggaaaaa gagcacggag gggaggggtg ttcctagcag tataaaagcc      180

ggttttctgg gctttctctg actcgctgta gtaattccag cgagaggcag agggagcgag      240

cgggcgggcc ctccagggtg gaagagcaga gccggccgag caatctgagt cgcgctctgg      300

gcgcccgggg gaagggagat ccggagtgaa agagggtctt cgcctccgtc ccggccgccc      360

ccaccccacc ctgcccgccg acccctgcca gcggtccgcc acccgcgccg catccacgaa      420

actttgccca ctgcagcggg cgggtacttt ccactggaac ttacaacacc cgagcgacaa      480

cgcgactctc cggacgcgga gaggctattc tgcctatttg gggagacact tttccctgtc      540

gctgcccacg actcgctcct ctgaaaggcg ctcctcgccg ctttttggac gc              592


<210>  5
<211>  1221
<212>  DNA
<213>  Homo sapiens

<400>  5
atgtctgcga gccaggattc ccgatccaga gacaatggcc ccgatgggat ggagcccgaa       60

ggcgtcatcg agagtaactg gaatgagatt gttgacagct ttgatgacat gaacctctcg      120

gagtcccttc tccgtggcat ctacgcgtat ggttttgaga agccctctgc catccagcag      180

cgagccattc taccttgtat caagggttat gatgtgattg ctcaagccca atctgggact      240

gggaaaacgg ccacatttgc catatcgatt ctgcagcaga ttgaattaga tctaaaagcc      300

acccaggcct tggtcctagc acccactcga gaattggctc agcagataca gaaggtggtc      360

atggcactag gagactacat gggcgcctcc tgtcacgcct gtatcggggg caccaacgtg      420

cgtgctgagg tgcagaaact gcagatggaa gctccccaca tcatcgtggg tacccctggc      480

cgtgtgtttg atatgcttaa ccggagatac ctgtccccca aatacatcaa gatgtttgta      540

ctggatgaag ctgacgaaat gttaagccgt ggattcaagg accagatcta tgacatattc      600

caaaagctca acagcaacac ccaggtagtt ttgctgtcag ccacaatgcc ttctgatgtg      660

cttgaggtga ccaagaagtt catgagggac cccattcgga ttcttgtcaa gaaggaagag      720

ttgaccctgg agggtatccg ccagttctac atcaacgtgg aacgagagga gtggaagctg      780

gacacactat gtgacttgta tgaaaccctg accatcaccc aggcagtcat cttcatcaac      840

acccggagga aggtggactg gctcaccgag aagatgcatg ctcgagattt cactgtatcc      900

gccatgcatg gagatatgga ccaaaaggaa cgagacgtga ttatgaggga gtttcgttct      960

ggctctagca gagttttgat taccactgac ctgctggcca gaggcattga tgtgcagcag     1020

gtttctttag tcatcaacta tgaccttccc accaacaggg aaaactatat ccacagaatc     1080

ggtcgaggtg gacggtttgg ccgtaaaggt gtggctatta acatggtgac agaagaagac     1140

aagaggactc ttcgagacat tgagaccttc tacaacacct ccattgagga aatgcccctc     1200

aatgttgctg acctcatctg a                                               1221


<210>  6
<211>  406
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ser Ala Ser Gln Asp Ser Arg Ser Arg Asp Asn Gly Pro Asp Gly 
1               5                   10                  15      


Met Glu Pro Glu Gly Val Ile Glu Ser Asn Trp Asn Glu Ile Val Asp 
            20                  25                  30          


Ser Phe Asp Asp Met Asn Leu Ser Glu Ser Leu Leu Arg Gly Ile Tyr 
        35                  40                  45              


Ala Tyr Gly Phe Glu Lys Pro Ser Ala Ile Gln Gln Arg Ala Ile Leu 
    50                  55                  60                  


Pro Cys Ile Lys Gly Tyr Asp Val Ile Ala Gln Ala Gln Ser Gly Thr 
65                  70                  75                  80  


Gly Lys Thr Ala Thr Phe Ala Ile Ser Ile Leu Gln Gln Ile Glu Leu 
                85                  90                  95      


Asp Leu Lys Ala Thr Gln Ala Leu Val Leu Ala Pro Thr Arg Glu Leu 
            100                 105                 110         


Ala Gln Gln Ile Gln Lys Val Val Met Ala Leu Gly Asp Tyr Met Gly 
        115                 120                 125             


Ala Ser Cys His Ala Cys Ile Gly Gly Thr Asn Val Arg Ala Glu Val 
    130                 135                 140                 


Gln Lys Leu Gln Met Glu Ala Pro His Ile Ile Val Gly Thr Pro Gly 
145                 150                 155                 160 


Arg Val Phe Asp Met Leu Asn Arg Arg Tyr Leu Ser Pro Lys Tyr Ile 
                165                 170                 175     


Lys Met Phe Val Leu Asp Glu Ala Asp Glu Met Leu Ser Arg Gly Phe 
            180                 185                 190         


Lys Asp Gln Ile Tyr Asp Ile Phe Gln Lys Leu Asn Ser Asn Thr Gln 
        195                 200                 205             


Val Val Leu Leu Ser Ala Thr Met Pro Ser Asp Val Leu Glu Val Thr 
    210                 215                 220                 


Lys Lys Phe Met Arg Asp Pro Ile Arg Ile Leu Val Lys Lys Glu Glu 
225                 230                 235                 240 


Leu Thr Leu Glu Gly Ile Arg Gln Phe Tyr Ile Asn Val Glu Arg Glu 
                245                 250                 255     


Glu Trp Lys Leu Asp Thr Leu Cys Asp Leu Tyr Glu Thr Leu Thr Ile 
            260                 265                 270         


Thr Gln Ala Val Ile Phe Ile Asn Thr Arg Arg Lys Val Asp Trp Leu 
        275                 280                 285             


Thr Glu Lys Met His Ala Arg Asp Phe Thr Val Ser Ala Met His Gly 
    290                 295                 300                 


Asp Met Asp Gln Lys Glu Arg Asp Val Ile Met Arg Glu Phe Arg Ser 
305                 310                 315                 320 


Gly Ser Ser Arg Val Leu Ile Thr Thr Asp Leu Leu Ala Arg Gly Ile 
                325                 330                 335     


Asp Val Gln Gln Val Ser Leu Val Ile Asn Tyr Asp Leu Pro Thr Asn 
            340                 345                 350         


Arg Glu Asn Tyr Ile His Arg Ile Gly Arg Gly Gly Arg Phe Gly Arg 
        355                 360                 365             


Lys Gly Val Ala Ile Asn Met Val Thr Glu Glu Asp Lys Arg Thr Leu 
    370                 375                 380                 


Arg Asp Ile Glu Thr Phe Tyr Asn Thr Ser Ile Glu Glu Met Pro Leu 
385                 390                 395                 400 


Asn Val Ala Asp Leu Ile 
                405     


<210>  7
<211>  1044
<212>  DNA
<213>  Homo sapiens

<400>  7
atgtctgcga gccaggattc ccgatccaga gacaatggcc ccgatgggat ggagcccgaa       60

ggcgtcatcg agagtaactg gaatgagatt gttgacagct ttgatgacat gaacctctcg      120

gagtcccttc tccgtggcat ctacgcgtat ggttttgaga agccctctgc catccagcag      180

cgagccattc taccttgtat caagggttat gatgtgattg ctcaagccca atctgggact      240

gggaaaacgg ccacatttgc catatcgatt ctgcagcaga ttgaattaga tctaaaagcc      300

acccaggcct tggtcctagc acccactcga gaattggctc agcagataca gaaggtggtc      360

atggcactag gagactacat gggcgcctcc tgtcacgcct gtatcggggg caccaacgtg      420

cgtgctgagg tgcagaaact gcagatggaa gctccccaca tcatcgtggg tacccctggc      480

cgtgtgtttg atatgcttaa ccggagatac ctgtccccca aatacatcaa gatgtttgta      540

ctggatgaag ctgacgaaat gttaagccgt ggattcaagg accagatcta tgacatattc      600

caaaagctca acagcaacac ccaggtagtt ttgctgtcag ccacaatgcc ttctgatgtg      660

cttgaggtga ccaagaagtt catgagggac cccattcgga ttcttgtcaa gaaggaagag      720

ttgaccctgg agggtatccg ccagttctac atcaacgtgg aacgagagga gtggaagctg      780

gacacactat gtgacttgta tgaaaccctg accatcaccc aggcagtcat cttcatcaac      840

acccggagga aggtggactg gctcaccgag aagatgcatg ctcgagattt cactgtatcc      900

gccatgcatg gagatatgga ccaaaaggaa cgagacgtga ttatgaggga gtttcgttct      960

ggctctagca gagttttgat taccactgac ctgctgggaa aactatatcc acagaatcgg     1020

tcgaggtgga cggtttggcc gtaa                                            1044


<210>  8
<211>  347
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ser Ala Ser Gln Asp Ser Arg Ser Arg Asp Asn Gly Pro Asp Gly 
1               5                   10                  15      


Met Glu Pro Glu Gly Val Ile Glu Ser Asn Trp Asn Glu Ile Val Asp 
            20                  25                  30          


Ser Phe Asp Asp Met Asn Leu Ser Glu Ser Leu Leu Arg Gly Ile Tyr 
        35                  40                  45              


Ala Tyr Gly Phe Glu Lys Pro Ser Ala Ile Gln Gln Arg Ala Ile Leu 
    50                  55                  60                  


Pro Cys Ile Lys Gly Tyr Asp Val Ile Ala Gln Ala Gln Ser Gly Thr 
65                  70                  75                  80  


Gly Lys Thr Ala Thr Phe Ala Ile Ser Ile Leu Gln Gln Ile Glu Leu 
                85                  90                  95      


Asp Leu Lys Ala Thr Gln Ala Leu Val Leu Ala Pro Thr Arg Glu Leu 
            100                 105                 110         


Ala Gln Gln Ile Gln Lys Val Val Met Ala Leu Gly Asp Tyr Met Gly 
        115                 120                 125             


Ala Ser Cys His Ala Cys Ile Gly Gly Thr Asn Val Arg Ala Glu Val 
    130                 135                 140                 


Gln Lys Leu Gln Met Glu Ala Pro His Ile Ile Val Gly Thr Pro Gly 
145                 150                 155                 160 


Arg Val Phe Asp Met Leu Asn Arg Arg Tyr Leu Ser Pro Lys Tyr Ile 
                165                 170                 175     


Lys Met Phe Val Leu Asp Glu Ala Asp Glu Met Leu Ser Arg Gly Phe 
            180                 185                 190         


Lys Asp Gln Ile Tyr Asp Ile Phe Gln Lys Leu Asn Ser Asn Thr Gln 
        195                 200                 205             


Val Val Leu Leu Ser Ala Thr Met Pro Ser Asp Val Leu Glu Val Thr 
    210                 215                 220                 


Lys Lys Phe Met Arg Asp Pro Ile Arg Ile Leu Val Lys Lys Glu Glu 
225                 230                 235                 240 


Leu Thr Leu Glu Gly Ile Arg Gln Phe Tyr Ile Asn Val Glu Arg Glu 
                245                 250                 255     


Glu Trp Lys Leu Asp Thr Leu Cys Asp Leu Tyr Glu Thr Leu Thr Ile 
            260                 265                 270         


Thr Gln Ala Val Ile Phe Ile Asn Thr Arg Arg Lys Val Asp Trp Leu 
        275                 280                 285             


Thr Glu Lys Met His Ala Arg Asp Phe Thr Val Ser Ala Met His Gly 
    290                 295                 300                 


Asp Met Asp Gln Lys Glu Arg Asp Val Ile Met Arg Glu Phe Arg Ser 
305                 310                 315                 320 


Gly Ser Ser Arg Val Leu Ile Thr Thr Asp Leu Leu Gly Lys Leu Tyr 
                325                 330                 335     


Pro Gln Asn Arg Ser Arg Trp Thr Val Trp Pro 
            340                 345         


<210>  9
<211>  1221
<212>  DNA
<213>  Mus musculus

<400>  9
atgtctgcga gtcaggattc tcgatccaga gacaatggcc ccgacgggat ggagccggaa       60

ggcgtcatcg agagtaactg gaacgagatt gtggatagct ttgatgacat gaatctctca      120

gagtccctcc tccgtggtat ttatgcctat ggttttgaga agccctctgc catccagcag      180

cgagctattc ttccttgtat caagggttat gatgtgattg ctcaagccca gtctgggact      240

gggaaaacag ctacatttgc catatcaatt ctgcagcaga ttgaattaga tctaaaggcc      300

actcaggctt tggttctggc acccacacgt gaattggctc agcagataca aaaggtggtt      360

atggcattag gagactacat gggtgcctct tgtcatgcct gcattggggg caccaatgtg      420

cgtgctgagg tgcagaagct gcagatggaa gctccccata tcatcgtggg tacccctggc      480

cgggtgtttg acatgcttaa ccggagatac ctgtccccca aatacatcaa gatgttcgta      540

ctggatgaag cagatgaaat gttaagccga gggttcaagg atcagatcta tgacatattc      600

cagaagctca acagcaacac acaggtagtt ttgttgtctg ctacaatgcc ttctgatgtc      660

cttgaggtga ccaagaaatt tatgagagac cctattcgga ttcttgtcaa gaaggaagaa      720

ttgaccctgg agggtatccg ccaattctac atcaatgtgg aacgagagga gtggaagctt      780

gacacattgt gtgacttgta tgagacgctg accatcaccc aggcagtcat ctttatcaac      840

accagaagga aggtggactg gctcaccgag aagatgcatg cccgagattt cactgtttct      900

gccatgcacg gagatatgga ccaaaaggaa cgagatgtga tcatgaggga gttccggtct      960

ggctctagca gagtattaat taccactgac ctgttggcca gaggcattga tgtgcagcag     1020

gtctccttag tcatcaacta tgaccttccc accaacaggg aaaactacat ccacagaatc     1080

ggtcgaggtg gtcggtttgg tcgtaagggt gtggctatta acatggtgac cgaagaagac     1140

aagaggactc ttcgagacat tgagactttc tacaacacct ccattgaaga gatgcccctc     1200

aacgttgctg acctcatttg a                                               1221


<210>  10
<211>  406
<212>  PRT
<213>  Mus musculus

<400>  10

Met Ser Ala Ser Gln Asp Ser Arg Ser Arg Asp Asn Gly Pro Asp Gly 
1               5                   10                  15      


Met Glu Pro Glu Gly Val Ile Glu Ser Asn Trp Asn Glu Ile Val Asp 
            20                  25                  30          


Ser Phe Asp Asp Met Asn Leu Ser Glu Ser Leu Leu Arg Gly Ile Tyr 
        35                  40                  45              


Ala Tyr Gly Phe Glu Lys Pro Ser Ala Ile Gln Gln Arg Ala Ile Leu 
    50                  55                  60                  


Pro Cys Ile Lys Gly Tyr Asp Val Ile Ala Gln Ala Gln Ser Gly Thr 
65                  70                  75                  80  


Gly Lys Thr Ala Thr Phe Ala Ile Ser Ile Leu Gln Gln Ile Glu Leu 
                85                  90                  95      


Asp Leu Lys Ala Thr Gln Ala Leu Val Leu Ala Pro Thr Arg Glu Leu 
            100                 105                 110         


Ala Gln Gln Ile Gln Lys Val Val Met Ala Leu Gly Asp Tyr Met Gly 
        115                 120                 125             


Ala Ser Cys His Ala Cys Ile Gly Gly Thr Asn Val Arg Ala Glu Val 
    130                 135                 140                 


Gln Lys Leu Gln Met Glu Ala Pro His Ile Ile Val Gly Thr Pro Gly 
145                 150                 155                 160 


Arg Val Phe Asp Met Leu Asn Arg Arg Tyr Leu Ser Pro Lys Tyr Ile 
                165                 170                 175     


Lys Met Phe Val Leu Asp Glu Ala Asp Glu Met Leu Ser Arg Gly Phe 
            180                 185                 190         


Lys Asp Gln Ile Tyr Asp Ile Phe Gln Lys Leu Asn Ser Asn Thr Gln 
        195                 200                 205             


Val Val Leu Leu Ser Ala Thr Met Pro Ser Asp Val Leu Glu Val Thr 
    210                 215                 220                 


Lys Lys Phe Met Arg Asp Pro Ile Arg Ile Leu Val Lys Lys Glu Glu 
225                 230                 235                 240 


Leu Thr Leu Glu Gly Ile Arg Gln Phe Tyr Ile Asn Val Glu Arg Glu 
                245                 250                 255     


Glu Trp Lys Leu Asp Thr Leu Cys Asp Leu Tyr Glu Thr Leu Thr Ile 
            260                 265                 270         


Thr Gln Ala Val Ile Phe Ile Asn Thr Arg Arg Lys Val Asp Trp Leu 
        275                 280                 285             


Thr Glu Lys Met His Ala Arg Asp Phe Thr Val Ser Ala Met His Gly 
    290                 295                 300                 


Asp Met Asp Gln Lys Glu Arg Asp Val Ile Met Arg Glu Phe Arg Ser 
305                 310                 315                 320 


Gly Ser Ser Arg Val Leu Ile Thr Thr Asp Leu Leu Ala Arg Gly Ile 
                325                 330                 335     


Asp Val Gln Gln Val Ser Leu Val Ile Asn Tyr Asp Leu Pro Thr Asn 
            340                 345                 350         


Arg Glu Asn Tyr Ile His Arg Ile Gly Arg Gly Gly Arg Phe Gly Arg 
        355                 360                 365             


Lys Gly Val Ala Ile Asn Met Val Thr Glu Glu Asp Lys Arg Thr Leu 
    370                 375                 380                 


Arg Asp Ile Glu Thr Phe Tyr Asn Thr Ser Ile Glu Glu Met Pro Leu 
385                 390                 395                 400 


Asn Val Ala Asp Leu Ile 
                405     


<210>  11
<211>  1221
<212>  DNA
<213>  Pan troglodytes

<400>  11
atgtctgcga gccaggattc ccgatccaga gacaatggcc ccgatgggat ggagcccgaa       60

ggcgtcatcg agagtaactg gaatgagatt gttgacagct ttgatgacat gaacctctcg      120

gagtcccttc tccgtggtat ctacgcctat ggttttgaga agccctctgc catccagcag      180

cgagccattc taccttgtat caagggttat gatgtgattg ctcaagccca atctgggact      240

gggaaaacgg ccacatttgc catatcgatt ctgcagcaga ttgaattaga tctaaaagcc      300

acccaggcct tggtcctagc acccactcga gaattggctc agcagataca gaaggtggtc      360

atggcattag gagactacat gggcgcctcc tgtcacgcct gtatcggggg caccaacgtg      420

cgtgctgagg tgcagaaact gcagatggaa gctccccaca tcatcgtggg tacccctggc      480

cgtgtgtttg atatgcttaa ccggagatac ctgtccccca agtacatcaa gatgtttgta      540

ctggatgaag ctgacgaaat gttaagccgt ggattcaagg accagatcta tgacatattc      600

caaaagctca acagcaacac ccaggtagtt ttgctgtcag ccacaatgcc ttctgatgtg      660

cttgaggtga ccaagaagtt catgagggac cccattcgga ttctcgtcaa gaaggaagag      720

ttgaccctgg agggtatccg ccagttctac atcaacgtgg aacgagagga gtggaagctg      780

gacacactat gtgacttgta tgaaaccctg accatcaccc aggcagtcat cttcatcaac      840

acccggagga aggtggactg gctcaccgag aagatgcatg ctcgagattt cactgtatcc      900

gccatgcatg gagatatgga ccaaaaggaa cgagacgtga tcatgaggga gtttcgttct      960

ggctctagca gagttttgat taccactgac ctgctggcca gaggcattga tgtgcagcag     1020

gtttctttag tcatcaacta tgaccttccc accaacaggg aaaactatat ccacagaatc     1080

ggtcgaggtg gacggttcgg ccgtaaaggt gtgactatta acatggtgac agaagaagac     1140

aagaggactc ttcgagacat tgagaccttt tacaacacct ccattgagga aatgcccctc     1200

aatgttgctg acctcatctg a                                               1221


<210>  12
<211>  406
<212>  PRT
<213>  Pan troglodytes

<400>  12

Met Ser Ala Ser Gln Asp Ser Arg Ser Arg Asp Asn Gly Pro Asp Gly 
1               5                   10                  15      


Met Glu Pro Glu Gly Val Ile Glu Ser Asn Trp Asn Glu Ile Val Asp 
            20                  25                  30          


Ser Phe Asp Asp Met Asn Leu Ser Glu Ser Leu Leu Arg Gly Ile Tyr 
        35                  40                  45              


Ala Tyr Gly Phe Glu Lys Pro Ser Ala Ile Gln Gln Arg Ala Ile Leu 
    50                  55                  60                  


Pro Cys Ile Lys Gly Tyr Asp Val Ile Ala Gln Ala Gln Ser Gly Thr 
65                  70                  75                  80  


Gly Lys Thr Ala Thr Phe Ala Ile Ser Ile Leu Gln Gln Ile Glu Leu 
                85                  90                  95      


Asp Leu Lys Ala Thr Gln Ala Leu Val Leu Ala Pro Thr Arg Glu Leu 
            100                 105                 110         


Ala Gln Gln Ile Gln Lys Val Val Met Ala Leu Gly Asp Tyr Met Gly 
        115                 120                 125             


Ala Ser Cys His Ala Cys Ile Gly Gly Thr Asn Val Arg Ala Glu Val 
    130                 135                 140                 


Gln Lys Leu Gln Met Glu Ala Pro His Ile Ile Val Gly Thr Pro Gly 
145                 150                 155                 160 


Arg Val Phe Asp Met Leu Asn Arg Arg Tyr Leu Ser Pro Lys Tyr Ile 
                165                 170                 175     


Lys Met Phe Val Leu Asp Glu Ala Asp Glu Met Leu Ser Arg Gly Phe 
            180                 185                 190         


Lys Asp Gln Ile Tyr Asp Ile Phe Gln Lys Leu Asn Ser Asn Thr Gln 
        195                 200                 205             


Val Val Leu Leu Ser Ala Thr Met Pro Ser Asp Val Leu Glu Val Thr 
    210                 215                 220                 


Lys Lys Phe Met Arg Asp Pro Ile Arg Ile Leu Val Lys Lys Glu Glu 
225                 230                 235                 240 


Leu Thr Leu Glu Gly Ile Arg Gln Phe Tyr Ile Asn Val Glu Arg Glu 
                245                 250                 255     


Glu Trp Lys Leu Asp Thr Leu Cys Asp Leu Tyr Glu Thr Leu Thr Ile 
            260                 265                 270         


Thr Gln Ala Val Ile Phe Ile Asn Thr Arg Arg Lys Val Asp Trp Leu 
        275                 280                 285             


Thr Glu Lys Met His Ala Arg Asp Phe Thr Val Ser Ala Met His Gly 
    290                 295                 300                 


Asp Met Asp Gln Lys Glu Arg Asp Val Ile Met Arg Glu Phe Arg Ser 
305                 310                 315                 320 


Gly Ser Ser Arg Val Leu Ile Thr Thr Asp Leu Leu Ala Arg Gly Ile 
                325                 330                 335     


Asp Val Gln Gln Val Ser Leu Val Ile Asn Tyr Asp Leu Pro Thr Asn 
            340                 345                 350         


Arg Glu Asn Tyr Ile His Arg Ile Gly Arg Gly Gly Arg Phe Gly Arg 
        355                 360                 365             


Lys Gly Val Thr Ile Asn Met Val Thr Glu Glu Asp Lys Arg Thr Leu 
    370                 375                 380                 


Arg Asp Ile Glu Thr Phe Tyr Asn Thr Ser Ile Glu Glu Met Pro Leu 
385                 390                 395                 400 


Asn Val Ala Asp Leu Ile 
                405     


<210>  13
<211>  1221
<212>  DNA
<213>  Macaca mulatta

<400>  13
atgtctgcga gccaggattc ccgatccaga gacaatggcc ccgatggaat ggagcccgaa       60

ggcgtcatcg agagtaactg gaatgagatt gttgacagct ttgatgacat gaacctctca      120

gagtctcttc tccgtggcat ctacgcctat ggttttgaga agccgtctgc catccagcag      180

cgagccattc taccttgtat caagggttac gatgtgatcg ctcaagccca atctgggact      240

gggaaaacgg ccacatttgc catatcaatt ctgcagcaga tcgaattaga tctaaaagcc      300

acccaggcct tggtcctggc acccactcga gaattggctc agcagataca gaaggtggtc      360

atggcactag gagactacat gggtgcctcc tgtcatgcct gtattggggg caccaacgtg      420

cgtgctgagg tgcagaaact gcagatggaa gccccccaca taatcatggg gacccctggc      480

cgagtgtttg atatgcttaa ccggagatac ctgtctccca aatacatcaa gatgtttgta      540

ctggacgaag ctgatgaaat gttaagccgt ggattcaagg accagatcta tgacatattc      600

caaaagctca acagcaacac ccaggtagtt ttgctgtcag ctacaatgcc ttctgatgtg      660

cttgaggtga ccaagaagtt catgagggac cccattcgga ttcttgtcaa gaaggaagag      720

ttgaccctgg agggtatctg ccaattctac atcaacgtgg aacgagagga gtggaagctg      780

gacacactat gtgacttgta tgaaacgctg accatcaccc aggcagtcat cttcatcaac      840

acccagagga aggtggactg gctcaccgag aagatgcatg ctcgagattt cactgtctct      900

gccatgcatg gagatatgga ccaaaaggaa cgagacgtga tcatgaggga gtttcgttct      960

ggctctagca gagttttgat taccactgac ctgctggcca gaggcattga tgtgcagcag     1020

gtttctttag tcatcaacta tgaccttccc accaacaggg aaaactatat ccacagaatc     1080

ggtcgaggtg gacggtttgg ccgtaaaggt gtggctatta acatggtgac agaagaagac     1140

aagaggactc ttcgagacat cgagaccttc tataacacct ccattgagga aatgcccctc     1200

aatgttgccg acctcatctg a                                               1221


<210>  14
<211>  406
<212>  PRT
<213>  Macaca mulatta

<400>  14

Met Ser Ala Ser Gln Asp Ser Arg Ser Arg Asp Asn Gly Pro Asp Gly 
1               5                   10                  15      


Met Glu Pro Glu Gly Val Ile Glu Ser Asn Trp Asn Glu Ile Val Asp 
            20                  25                  30          


Ser Phe Asp Asp Met Asn Leu Ser Glu Ser Leu Leu Arg Gly Ile Tyr 
        35                  40                  45              


Ala Tyr Gly Phe Glu Lys Pro Ser Ala Ile Gln Gln Arg Ala Ile Leu 
    50                  55                  60                  


Pro Cys Ile Lys Gly Tyr Asp Val Ile Ala Gln Ala Gln Ser Gly Thr 
65                  70                  75                  80  


Gly Lys Thr Ala Thr Phe Ala Ile Ser Ile Leu Gln Gln Ile Glu Leu 
                85                  90                  95      


Asp Leu Lys Ala Thr Gln Ala Leu Val Leu Ala Pro Thr Arg Glu Leu 
            100                 105                 110         


Ala Gln Gln Ile Gln Lys Val Val Met Ala Leu Gly Asp Tyr Met Gly 
        115                 120                 125             


Ala Ser Cys His Ala Cys Ile Gly Gly Thr Asn Val Arg Ala Glu Val 
    130                 135                 140                 


Gln Lys Leu Gln Met Glu Ala Pro His Ile Ile Met Gly Thr Pro Gly 
145                 150                 155                 160 


Arg Val Phe Asp Met Leu Asn Arg Arg Tyr Leu Ser Pro Lys Tyr Ile 
                165                 170                 175     


Lys Met Phe Val Leu Asp Glu Ala Asp Glu Met Leu Ser Arg Gly Phe 
            180                 185                 190         


Lys Asp Gln Ile Tyr Asp Ile Phe Gln Lys Leu Asn Ser Asn Thr Gln 
        195                 200                 205             


Val Val Leu Leu Ser Ala Thr Met Pro Ser Asp Val Leu Glu Val Thr 
    210                 215                 220                 


Lys Lys Phe Met Arg Asp Pro Ile Arg Ile Leu Val Lys Lys Glu Glu 
225                 230                 235                 240 


Leu Thr Leu Glu Gly Ile Cys Gln Phe Tyr Ile Asn Val Glu Arg Glu 
                245                 250                 255     


Glu Trp Lys Leu Asp Thr Leu Cys Asp Leu Tyr Glu Thr Leu Thr Ile 
            260                 265                 270         


Thr Gln Ala Val Ile Phe Ile Asn Thr Gln Arg Lys Val Asp Trp Leu 
        275                 280                 285             


Thr Glu Lys Met His Ala Arg Asp Phe Thr Val Ser Ala Met His Gly 
    290                 295                 300                 


Asp Met Asp Gln Lys Glu Arg Asp Val Ile Met Arg Glu Phe Arg Ser 
305                 310                 315                 320 


Gly Ser Ser Arg Val Leu Ile Thr Thr Asp Leu Leu Ala Arg Gly Ile 
                325                 330                 335     


Asp Val Gln Gln Val Ser Leu Val Ile Asn Tyr Asp Leu Pro Thr Asn 
            340                 345                 350         


Arg Glu Asn Tyr Ile His Arg Ile Gly Arg Gly Gly Arg Phe Gly Arg 
        355                 360                 365             


Lys Gly Val Ala Ile Asn Met Val Thr Glu Glu Asp Lys Arg Thr Leu 
    370                 375                 380                 


Arg Asp Ile Glu Thr Phe Tyr Asn Thr Ser Ile Glu Glu Met Pro Leu 
385                 390                 395                 400 


Asn Val Ala Asp Leu Ile 
                405     


<210>  15
<211>  1221
<212>  DNA
<213>  Canis familiaris

<400>  15
atgtctgcga gtcaggattc ccgatccaga gacaatggcc ccgatgggat ggagcccgaa       60

ggcgtcatcg agagtaactg gaatgagatt gttgacagct ttgatgacat gaacctctcc      120

gagtcccttc tccgtggcat ctatgcttat ggtttcgaga agccttctgc catccagcag      180

cgagccattc ttccttgtat caagggttat gatgtgatcg ctcaagccca atctgggact      240

gggaaaacag ccacttttgc catatcgatt ctgcaacaaa ttgaattgga tctaaaggct      300

acacaggcct tggtcctggc acccactagg gagttggctc agcagataca gaaggtagtc      360

atggcattag gagattacat gggtgcttcc tgccatgcct gcattggggg gaccaatgta      420

cgtgctgagg tgcagaagct tcagatggag gctcctcata tcatcgtggg caccccgggt      480

cgtgtgtttg acatgctgaa ccggagatac ctatctccca aatatatcaa gatgtttgta      540

ctggacgaag ctgatgagat gttaagccgt ggattcaagg accagatcta tgacatattc      600

caaaagctca acagcaacac ccaggtggtt ttgctgtctg ccacgatgcc ttctgacgtg      660

cttgaggtga ccaagaagtt catgagggac cccattcgga ttctggtcaa gaaagaagag      720

ttgaccctcg agggcatccg ccagttctac atcaacgtgg agcgagagga gtggaagctg      780

gacacgctgt gtgacttgta cgagactctg accatcacac aggcagtcat tttcatcaac      840

acccgaagga aggtggattg gctcaccgag aagatgcacg cccgagactt caccgtgtct      900

gccatgcacg gagacatgga ccagaaggag cgagatgtta tcatgaggga gttccgctcg      960

ggctctagca gagtactgat taccactgac ttgctggcca gaggcatcga tgtgcagcag     1020

gtgtctctag tcatcaacta tgaccttcct accaacaggg aaaactatat ccacagaatc     1080

ggccgtggtg gacgatttgg ccggaagggt gtggctatta acatggtgac agaagaagac     1140

aagaggactc ttcgagacat cgagactttc tacaacacct ccattgagga aatgcccctc     1200

aatgttgctg acctcatctg a                                               1221


<210>  16
<211>  406
<212>  PRT
<213>  Canis familiaris

<400>  16

Met Ser Ala Ser Gln Asp Ser Arg Ser Arg Asp Asn Gly Pro Asp Gly 
1               5                   10                  15      


Met Glu Pro Glu Gly Val Ile Glu Ser Asn Trp Asn Glu Ile Val Asp 
            20                  25                  30          


Ser Phe Asp Asp Met Asn Leu Ser Glu Ser Leu Leu Arg Gly Ile Tyr 
        35                  40                  45              


Ala Tyr Gly Phe Glu Lys Pro Ser Ala Ile Gln Gln Arg Ala Ile Leu 
    50                  55                  60                  


Pro Cys Ile Lys Gly Tyr Asp Val Ile Ala Gln Ala Gln Ser Gly Thr 
65                  70                  75                  80  


Gly Lys Thr Ala Thr Phe Ala Ile Ser Ile Leu Gln Gln Ile Glu Leu 
                85                  90                  95      


Asp Leu Lys Ala Thr Gln Ala Leu Val Leu Ala Pro Thr Arg Glu Leu 
            100                 105                 110         


Ala Gln Gln Ile Gln Lys Val Val Met Ala Leu Gly Asp Tyr Met Gly 
        115                 120                 125             


Ala Ser Cys His Ala Cys Ile Gly Gly Thr Asn Val Arg Ala Glu Val 
    130                 135                 140                 


Gln Lys Leu Gln Met Glu Ala Pro His Ile Ile Val Gly Thr Pro Gly 
145                 150                 155                 160 


Arg Val Phe Asp Met Leu Asn Arg Arg Tyr Leu Ser Pro Lys Tyr Ile 
                165                 170                 175     


Lys Met Phe Val Leu Asp Glu Ala Asp Glu Met Leu Ser Arg Gly Phe 
            180                 185                 190         


Lys Asp Gln Ile Tyr Asp Ile Phe Gln Lys Leu Asn Ser Asn Thr Gln 
        195                 200                 205             


Val Val Leu Leu Ser Ala Thr Met Pro Ser Asp Val Leu Glu Val Thr 
    210                 215                 220                 


Lys Lys Phe Met Arg Asp Pro Ile Arg Ile Leu Val Lys Lys Glu Glu 
225                 230                 235                 240 


Leu Thr Leu Glu Gly Ile Arg Gln Phe Tyr Ile Asn Val Glu Arg Glu 
                245                 250                 255     


Glu Trp Lys Leu Asp Thr Leu Cys Asp Leu Tyr Glu Thr Leu Thr Ile 
            260                 265                 270         


Thr Gln Ala Val Ile Phe Ile Asn Thr Arg Arg Lys Val Asp Trp Leu 
        275                 280                 285             


Thr Glu Lys Met His Ala Arg Asp Phe Thr Val Ser Ala Met His Gly 
    290                 295                 300                 


Asp Met Asp Gln Lys Glu Arg Asp Val Ile Met Arg Glu Phe Arg Ser 
305                 310                 315                 320 


Gly Ser Ser Arg Val Leu Ile Thr Thr Asp Leu Leu Ala Arg Gly Ile 
                325                 330                 335     


Asp Val Gln Gln Val Ser Leu Val Ile Asn Tyr Asp Leu Pro Thr Asn 
            340                 345                 350         


Arg Glu Asn Tyr Ile His Arg Ile Gly Arg Gly Gly Arg Phe Gly Arg 
        355                 360                 365             


Lys Gly Val Ala Ile Asn Met Val Thr Glu Glu Asp Lys Arg Thr Leu 
    370                 375                 380                 


Arg Asp Ile Glu Thr Phe Tyr Asn Thr Ser Ile Glu Glu Met Pro Leu 
385                 390                 395                 400 


Asn Val Ala Asp Leu Ile 
                405     


<210>  17
<211>  1221
<212>  DNA
<213>  Bos taurus

<400>  17
atgtctgcga gtcaggattc ccgatctaga gacaatggcc ccgatgggat ggaacccgaa       60

ggcgtcatcg agagtaactg gaatgagatt gtcgacagct ttgatgacat gaacctctca      120

gagtcactcc tccgtggcat atatgcctat ggttttgaga agccctctgc cattcagcag      180

cgagccattc ttccttgtat caagggttat gatgtgattg ctcaagccca atctgggact      240

gggaaaacgg ccacttttgc catatcaatt ctgcaacaga ttgaattaga tctaaaggcc      300

acccaggcct tggtcctggc acccactaga gagttggccc agcagataca gaaggtagta      360

atggccttag gagattacat gggtgcctcg tgccatgcct gcattggggg taccaatgta      420

cgtgctgagg tgcagaagct gcagatggaa gccccccata tcatcgtggg taccccaggc      480

cgtgtgttcg acatgcttaa ccggagatac ttgtctccca aatacatcaa gatgtttgta      540

ctggatgaag ctgatgaaat gttaagccgt ggattcaagg accagatcta tgacatattc      600

cagaagctca acagcaacac ccaggtggtt ttgctgtcag ctacaatgcc ttctgatgtg      660

cttgaggtga ccaagaagtt catgagggac ccaattagaa ttcttgtcaa gaaggaagag      720

ttgacgctgg agggtatccg tcagttctac atcaatgtgg aacgagagga gtggaagctg      780

gacacactgt gcgacttgta tgaaaccctg accattaccc aggcagtcat cttcatcaac      840

acccgaagga aggtggattg gctcaccgag aagatgcatg cccgagactt caccgtctct      900

gccatgcacg gagacatgga ccaaaaagaa cgagacgtta tcatgaggga gttccgctct      960

ggctctagca gagtattgat taccactgac ctactggcca gaggtattga tgtacagcaa     1020

gtttccttag tcatcaacta tgacctcccc accaataggg aaaactatat ccacagaatt     1080

ggtcgtggcg gacgtttcgg ccgtaagggt gtggctatta acatggtgac agaagaggac     1140

aagaggactc ttcgagacat cgaaaccttc tacaacacct ccattgagga aatgcccctc     1200

aatgttgctg acctcatctg a                                               1221


<210>  18
<211>  406
<212>  PRT
<213>  Bos taurus

<400>  18

Met Ser Ala Ser Gln Asp Ser Arg Ser Arg Asp Asn Gly Pro Asp Gly 
1               5                   10                  15      


Met Glu Pro Glu Gly Val Ile Glu Ser Asn Trp Asn Glu Ile Val Asp 
            20                  25                  30          


Ser Phe Asp Asp Met Asn Leu Ser Glu Ser Leu Leu Arg Gly Ile Tyr 
        35                  40                  45              


Ala Tyr Gly Phe Glu Lys Pro Ser Ala Ile Gln Gln Arg Ala Ile Leu 
    50                  55                  60                  


Pro Cys Ile Lys Gly Tyr Asp Val Ile Ala Gln Ala Gln Ser Gly Thr 
65                  70                  75                  80  


Gly Lys Thr Ala Thr Phe Ala Ile Ser Ile Leu Gln Gln Ile Glu Leu 
                85                  90                  95      


Asp Leu Lys Ala Thr Gln Ala Leu Val Leu Ala Pro Thr Arg Glu Leu 
            100                 105                 110         


Ala Gln Gln Ile Gln Lys Val Val Met Ala Leu Gly Asp Tyr Met Gly 
        115                 120                 125             


Ala Ser Cys His Ala Cys Ile Gly Gly Thr Asn Val Arg Ala Glu Val 
    130                 135                 140                 


Gln Lys Leu Gln Met Glu Ala Pro His Ile Ile Val Gly Thr Pro Gly 
145                 150                 155                 160 


Arg Val Phe Asp Met Leu Asn Arg Arg Tyr Leu Ser Pro Lys Tyr Ile 
                165                 170                 175     


Lys Met Phe Val Leu Asp Glu Ala Asp Glu Met Leu Ser Arg Gly Phe 
            180                 185                 190         


Lys Asp Gln Ile Tyr Asp Ile Phe Gln Lys Leu Asn Ser Asn Thr Gln 
        195                 200                 205             


Val Val Leu Leu Ser Ala Thr Met Pro Ser Asp Val Leu Glu Val Thr 
    210                 215                 220                 


Lys Lys Phe Met Arg Asp Pro Ile Arg Ile Leu Val Lys Lys Glu Glu 
225                 230                 235                 240 


Leu Thr Leu Glu Gly Ile Arg Gln Phe Tyr Ile Asn Val Glu Arg Glu 
                245                 250                 255     


Glu Trp Lys Leu Asp Thr Leu Cys Asp Leu Tyr Glu Thr Leu Thr Ile 
            260                 265                 270         


Thr Gln Ala Val Ile Phe Ile Asn Thr Arg Arg Lys Val Asp Trp Leu 
        275                 280                 285             


Thr Glu Lys Met His Ala Arg Asp Phe Thr Val Ser Ala Met His Gly 
    290                 295                 300                 


Asp Met Asp Gln Lys Glu Arg Asp Val Ile Met Arg Glu Phe Arg Ser 
305                 310                 315                 320 


Gly Ser Ser Arg Val Leu Ile Thr Thr Asp Leu Leu Ala Arg Gly Ile 
                325                 330                 335     


Asp Val Gln Gln Val Ser Leu Val Ile Asn Tyr Asp Leu Pro Thr Asn 
            340                 345                 350         


Arg Glu Asn Tyr Ile His Arg Ile Gly Arg Gly Gly Arg Phe Gly Arg 
        355                 360                 365             


Lys Gly Val Ala Ile Asn Met Val Thr Glu Glu Asp Lys Arg Thr Leu 
    370                 375                 380                 


Arg Asp Ile Glu Thr Phe Tyr Asn Thr Ser Ile Glu Glu Met Pro Leu 
385                 390                 395                 400 


Asn Val Ala Asp Leu Ile 
                405     


<210>  19
<211>  1221
<212>  DNA
<213>  Rattus norvegicus

<400>  19
atgtctgcga gtcaggattc tcgatccaga gacaatggcc ccgatgggat ggagccggaa       60

ggcgtcatcg agagtaactg gaatgagatt gtggatagct tcgatgacat gaatctctca      120

gaatccctcc tccgtggtat ttatgcctat ggttttgaga agccctctgc catccagcag      180

cgagctattc ttccttgtat caagggttat gatgtgattg ctcaagccca gtctgggact      240

gggaaaacag ctacatttgc catatccatt ctgcagcaga ttgaattaga tctaaaggcc      300

actcaggctt tggttctggc acccactcgt gaattggctc agcagattca aaaggtggtt      360

atggcactgg gagactacat gggtgcctct tgtcatgcct gtattggggg caccaacgtg      420

cgtgctgagg tgcagaagct gcaaatggaa gctccccata tcatcgtggg cacccctggc      480

cgggtgttcg atatgcttaa ccggagatac ctgtcaccca aatacatcaa gatgttcgtc      540

ctggatgaag cagatgaaat gctaagccgt gggttcaagg atcagatcta tgatatattc      600

caaaagctca acagcaacac acaggtagtt ttgctgtctg ccacaatgcc ttctgatgtc      660

cttgaggtga ctaagaagtt catgagagac cctattcgga ttcttgtcaa gaaggaagag      720

ttgaccctgg agggtatccg ccaattctac atcaatgtgg aacgagagga gtggaagctc      780

gacacattgt gtgacttgta tgaaacactg accatcaccc aggcagtaat ctttattaat      840

accagaagga aggtggactg gctcactgag aagatgcatg cccgggattt cacagtttct      900

gccatgcatg gagatatgga ccaaaaggaa cgagacgtga tcatgaggga gttccggtct      960

ggctctagca gagtattaat taccactgac ctgttggcca gaggcattga tgtgcagcag     1020

gtctccctag tcatcaatta tgaccttccc accaacaggg aaaactacat ccacagaatt     1080

ggtcgaggtg gtcggtttgg ccggaaaggt gtggctatta acatggtgac agaagaagac     1140

aagaggactc ttcgagacat tgagactttc tacaacacct ccattgaaga gatgcccctc     1200

aacgttgctg acctcatttg a                                               1221


<210>  20
<211>  406
<212>  PRT
<213>  Rattus norvegicus

<400>  20

Met Ser Ala Ser Gln Asp Ser Arg Ser Arg Asp Asn Gly Pro Asp Gly 
1               5                   10                  15      


Met Glu Pro Glu Gly Val Ile Glu Ser Asn Trp Asn Glu Ile Val Asp 
            20                  25                  30          


Ser Phe Asp Asp Met Asn Leu Ser Glu Ser Leu Leu Arg Gly Ile Tyr 
        35                  40                  45              


Ala Tyr Gly Phe Glu Lys Pro Ser Ala Ile Gln Gln Arg Ala Ile Leu 
    50                  55                  60                  


Pro Cys Ile Lys Gly Tyr Asp Val Ile Ala Gln Ala Gln Ser Gly Thr 
65                  70                  75                  80  


Gly Lys Thr Ala Thr Phe Ala Ile Ser Ile Leu Gln Gln Ile Glu Leu 
                85                  90                  95      


Asp Leu Lys Ala Thr Gln Ala Leu Val Leu Ala Pro Thr Arg Glu Leu 
            100                 105                 110         


Ala Gln Gln Ile Gln Lys Val Val Met Ala Leu Gly Asp Tyr Met Gly 
        115                 120                 125             


Ala Ser Cys His Ala Cys Ile Gly Gly Thr Asn Val Arg Ala Glu Val 
    130                 135                 140                 


Gln Lys Leu Gln Met Glu Ala Pro His Ile Ile Val Gly Thr Pro Gly 
145                 150                 155                 160 


Arg Val Phe Asp Met Leu Asn Arg Arg Tyr Leu Ser Pro Lys Tyr Ile 
                165                 170                 175     


Lys Met Phe Val Leu Asp Glu Ala Asp Glu Met Leu Ser Arg Gly Phe 
            180                 185                 190         


Lys Asp Gln Ile Tyr Asp Ile Phe Gln Lys Leu Asn Ser Asn Thr Gln 
        195                 200                 205             


Val Val Leu Leu Ser Ala Thr Met Pro Ser Asp Val Leu Glu Val Thr 
    210                 215                 220                 


Lys Lys Phe Met Arg Asp Pro Ile Arg Ile Leu Val Lys Lys Glu Glu 
225                 230                 235                 240 


Leu Thr Leu Glu Gly Ile Arg Gln Phe Tyr Ile Asn Val Glu Arg Glu 
                245                 250                 255     


Glu Trp Lys Leu Asp Thr Leu Cys Asp Leu Tyr Glu Thr Leu Thr Ile 
            260                 265                 270         


Thr Gln Ala Val Ile Phe Ile Asn Thr Arg Arg Lys Val Asp Trp Leu 
        275                 280                 285             


Thr Glu Lys Met His Ala Arg Asp Phe Thr Val Ser Ala Met His Gly 
    290                 295                 300                 


Asp Met Asp Gln Lys Glu Arg Asp Val Ile Met Arg Glu Phe Arg Ser 
305                 310                 315                 320 


Gly Ser Ser Arg Val Leu Ile Thr Thr Asp Leu Leu Ala Arg Gly Ile 
                325                 330                 335     


Asp Val Gln Gln Val Ser Leu Val Ile Asn Tyr Asp Leu Pro Thr Asn 
            340                 345                 350         


Arg Glu Asn Tyr Ile His Arg Ile Gly Arg Gly Gly Arg Phe Gly Arg 
        355                 360                 365             


Lys Gly Val Ala Ile Asn Met Val Thr Glu Glu Asp Lys Arg Thr Leu 
    370                 375                 380                 


Arg Asp Ile Glu Thr Phe Tyr Asn Thr Ser Ile Glu Glu Met Pro Leu 
385                 390                 395                 400 


Asn Val Ala Asp Leu Ile 
                405     


<210>  21
<211>  1836
<212>  DNA
<213>  Homo sapiens

<400>  21
atggcggcct cagcaaaaaa gaagaataag aaggggaaga ctatctccct aacagacttt       60

ctggctgagg atgggggtac tggtggagga agcacctatg tttccaaacc agtcagctgg      120

gctgatgaaa cggatgacct ggaaggagat gtttcgacca cttggcacag taacgatgac      180

gatgtgtata gggcgcctcc aattgaccgt tccatccttc ccactgctcc acgggctgct      240

cgggaaccca atatcgaccg gagccgtctt cccaaatcgc caccctacac tgcttttcta      300

ggaaacctac cctatgatgt tacagaagag tcaattaagg aattctttcg aggattaaat      360

atcagtgcag tgcgtttacc acgtgaaccc agcaatccag agaggttgaa aggttttggt      420

tatgctgaat ttgaggacct ggattccctg ctcagtgccc tgagtctcaa tgaagagtct      480

ctaggtaaca ggagaattcg agtggacgtt gctgatcaag cacaggataa agacagggat      540

gatcgttctt ttggccgtga tagaaatcgg gattctgaca aaacagatac agactggagg      600

gctcgtcctg ctacagacag ctttgatgac tacccaccta gaagaggtga tgatagcttt      660

ggagacaagt atcgagatcg ttatgattca gaccggtatc gggatgggta tcgggatggg      720

tatcgggatg gcccacgccg ggatatggat cgatatggtg gccgggatcg ctatgatgac      780

cgaggcagca gagactatga tagaggctat gattcccgga taggcagtgg cagaagagca      840

tttggcagtg ggtatcgcag ggatgatgac tacagaggag gcggggaccg ctatgaagac      900

cgatatgaca gacgggatga tcggtcgtgg agctccagag atgattactc tcgggatgat      960

tataggcgtg atgatagagg tcccccccaa agacccaaac tgaatctaaa gcctcggagt     1020

actcctaagg aagatgattc ctctgctagt acctcccagt ccactcgagc tgcttctatc     1080

tttggagggg caaagcctgt tgacacagct gctagagaaa gagaagtaga agaacggcta     1140

cagaaggaac aagagaagtt gcagcgtcag ctggatgagc caaaactaga acgacggcct     1200

cgggagagac acccaagctg gcgaagtgaa gaaactcagg aacgggaacg gtcgaggaca     1260

ggaagtgagt catcacaaac tgggacctcc accacatcta gcagaaatgc acgaaggaga     1320

gagagtgaga agtctctaga aaatgaaaca ctcaataagg aggaagattg ccactctcca     1380

acttctaaac ctcccaaacc tgatcagccc ctaaaggtaa tgccagcccc tccaccaaag     1440

gagaatgctt gggtgaagcg aagttctaac cctcctgctc gatctcagag ctcagacaca     1500

gagcagcagt cccctacaag tggtggggga aaagtagctc cagctcaacc atctgaggaa     1560

ggaccaggaa ggaaagatga aaataaagta gatgggatga atgccccaaa aggccaaact     1620

gggaactcta gccgtggtcc aggagacgga gggaacagag accactggaa ggagtcagat     1680

aggaaagatg gcaaaaagga tcaagactcc agatctgcac ctgagccaaa gaaacctgag     1740

gaaaatccag cttccaagtt cagttctgca agcaagtatg ctgctctctc tgttgatggt     1800

gaagatgaaa atgagggaga agattatgcc gaatag                               1836


<210>  22
<211>  611
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ala Ala Ser Ala Lys Lys Lys Asn Lys Lys Gly Lys Thr Ile Ser 
1               5                   10                  15      


Leu Thr Asp Phe Leu Ala Glu Asp Gly Gly Thr Gly Gly Gly Ser Thr 
            20                  25                  30          


Tyr Val Ser Lys Pro Val Ser Trp Ala Asp Glu Thr Asp Asp Leu Glu 
        35                  40                  45              


Gly Asp Val Ser Thr Thr Trp His Ser Asn Asp Asp Asp Val Tyr Arg 
    50                  55                  60                  


Ala Pro Pro Ile Asp Arg Ser Ile Leu Pro Thr Ala Pro Arg Ala Ala 
65                  70                  75                  80  


Arg Glu Pro Asn Ile Asp Arg Ser Arg Leu Pro Lys Ser Pro Pro Tyr 
                85                  90                  95      


Thr Ala Phe Leu Gly Asn Leu Pro Tyr Asp Val Thr Glu Glu Ser Ile 
            100                 105                 110         


Lys Glu Phe Phe Arg Gly Leu Asn Ile Ser Ala Val Arg Leu Pro Arg 
        115                 120                 125             


Glu Pro Ser Asn Pro Glu Arg Leu Lys Gly Phe Gly Tyr Ala Glu Phe 
    130                 135                 140                 


Glu Asp Leu Asp Ser Leu Leu Ser Ala Leu Ser Leu Asn Glu Glu Ser 
145                 150                 155                 160 


Leu Gly Asn Arg Arg Ile Arg Val Asp Val Ala Asp Gln Ala Gln Asp 
                165                 170                 175     


Lys Asp Arg Asp Asp Arg Ser Phe Gly Arg Asp Arg Asn Arg Asp Ser 
            180                 185                 190         


Asp Lys Thr Asp Thr Asp Trp Arg Ala Arg Pro Ala Thr Asp Ser Phe 
        195                 200                 205             


Asp Asp Tyr Pro Pro Arg Arg Gly Asp Asp Ser Phe Gly Asp Lys Tyr 
    210                 215                 220                 


Arg Asp Arg Tyr Asp Ser Asp Arg Tyr Arg Asp Gly Tyr Arg Asp Gly 
225                 230                 235                 240 


Tyr Arg Asp Gly Pro Arg Arg Asp Met Asp Arg Tyr Gly Gly Arg Asp 
                245                 250                 255     


Arg Tyr Asp Asp Arg Gly Ser Arg Asp Tyr Asp Arg Gly Tyr Asp Ser 
            260                 265                 270         


Arg Ile Gly Ser Gly Arg Arg Ala Phe Gly Ser Gly Tyr Arg Arg Asp 
        275                 280                 285             


Asp Asp Tyr Arg Gly Gly Gly Asp Arg Tyr Glu Asp Arg Tyr Asp Arg 
    290                 295                 300                 


Arg Asp Asp Arg Ser Trp Ser Ser Arg Asp Asp Tyr Ser Arg Asp Asp 
305                 310                 315                 320 


Tyr Arg Arg Asp Asp Arg Gly Pro Pro Gln Arg Pro Lys Leu Asn Leu 
                325                 330                 335     


Lys Pro Arg Ser Thr Pro Lys Glu Asp Asp Ser Ser Ala Ser Thr Ser 
            340                 345                 350         


Gln Ser Thr Arg Ala Ala Ser Ile Phe Gly Gly Ala Lys Pro Val Asp 
        355                 360                 365             


Thr Ala Ala Arg Glu Arg Glu Val Glu Glu Arg Leu Gln Lys Glu Gln 
    370                 375                 380                 


Glu Lys Leu Gln Arg Gln Leu Asp Glu Pro Lys Leu Glu Arg Arg Pro 
385                 390                 395                 400 


Arg Glu Arg His Pro Ser Trp Arg Ser Glu Glu Thr Gln Glu Arg Glu 
                405                 410                 415     


Arg Ser Arg Thr Gly Ser Glu Ser Ser Gln Thr Gly Thr Ser Thr Thr 
            420                 425                 430         


Ser Ser Arg Asn Ala Arg Arg Arg Glu Ser Glu Lys Ser Leu Glu Asn 
        435                 440                 445             


Glu Thr Leu Asn Lys Glu Glu Asp Cys His Ser Pro Thr Ser Lys Pro 
    450                 455                 460                 


Pro Lys Pro Asp Gln Pro Leu Lys Val Met Pro Ala Pro Pro Pro Lys 
465                 470                 475                 480 


Glu Asn Ala Trp Val Lys Arg Ser Ser Asn Pro Pro Ala Arg Ser Gln 
                485                 490                 495     


Ser Ser Asp Thr Glu Gln Gln Ser Pro Thr Ser Gly Gly Gly Lys Val 
            500                 505                 510         


Ala Pro Ala Gln Pro Ser Glu Glu Gly Pro Gly Arg Lys Asp Glu Asn 
        515                 520                 525             


Lys Val Asp Gly Met Asn Ala Pro Lys Gly Gln Thr Gly Asn Ser Ser 
    530                 535                 540                 


Arg Gly Pro Gly Asp Gly Gly Asn Arg Asp His Trp Lys Glu Ser Asp 
545                 550                 555                 560 


Arg Lys Asp Gly Lys Lys Asp Gln Asp Ser Arg Ser Ala Pro Glu Pro 
                565                 570                 575     


Lys Lys Pro Glu Glu Asn Pro Ala Ser Lys Phe Ser Ser Ala Ser Lys 
            580                 585                 590         


Tyr Ala Ala Leu Ser Val Asp Gly Glu Asp Glu Asn Glu Gly Glu Asp 
        595                 600                 605             


Tyr Ala Glu 
    610     


<210>  23
<211>  1836
<212>  DNA
<213>  Mus musculus

<400>  23
atggcggcct cagcaaaaaa gaagaataag aaggggaaga ccatctccct aacggacttt       60

ctagctgagg atggaggaac tggtggagga agcacctatg tccccaaacc agtcagctgg      120

gctgatgaaa cagacgatct ggaaggagat gtgtcaacaa cttggcatag taacgatgat      180

gacgtgtaca gggcgcctcc aattgaccgt tccatccttc ccactgctcc acgggctgct      240

cgggaaccca atattgaccg gagccgtctt cccaagtcgc caccctacac tgctttccta      300

gggaatctgc cctatgatgt gacagaagac tccattaagg atttctttag aggattaaat      360

atcagcgctg tacgcttacc acgggaaccc agcaatccag acaggttgaa aggtttcggc      420

tacgcagaat ttgaggacct ggattctctg ctcagtgctc tgagtctcaa tgaagagtct      480

ctaggtaaca ggagaattcg tgtggatgtt gctgatcaag cacaggataa agacagggat      540

gaccgttctt ttggtcgaga tagaaatcgg gattctgaca aaacagacac agactggagg      600

gcccgtccca ccacagacag ttttgatgac tacccaccta gaagaggcga tgatagcttt      660

ggagacaagt atcgagatcg ttacgattca gaccggtatc gggatgggta tagggacgga      720

tatcgggacg gcccacgcag agacatggac cgctatgggg gccgggatcg ctatgatgac      780

cgaggcagca gagactatga ccgaggctat gactccagga taggcagtgg cagaagggca      840

tttggaagtg ggtaccggag agatgatgac tacagaggag gtggggaccg ctatgaagac      900

cgctatgaca gacgggatga tcggtcgtgg agctccaggg atgactactc tcgggatgat      960

tataggcgtg atgacagagg tcccccccag agacccagac tgaacctcaa gcctcgaagc     1020

gctcctaagg aggatgacgc ctccgccagc acctcccagt ccagccgggc agcctccatc     1080

tttggagggg cgaagcctgt tgacacagct gctagggaaa gagaagtaga ggagcggcta     1140

cagaaggagc aggagaagct gcagcgtcag ctggatgagc caaaactaga ccgccggccc     1200

cgggagagac acccaagctg gcgaagtgaa gaaactcagg aaagagaacg gtcaaggaca     1260

ggaagtgagt catcgcagac tggggcctca gccacatctg gcagaaatac acgaaggaga     1320

gagagtgaga agtctctaga aaatgaaacc ctcaataaag aagaagactg tcactctcca     1380

acctctaagc ctcctaaacc tgaccagcct ctaaaggtaa tgccagcccc tccaccaaag     1440

gagaatgcgt gggtgaagcg aagctctaac cctcctgccc gatctcagag ctcagacaca     1500

gagcagccgt cccctacaag tggtggaggg aaagtagctg cagtccagcc ccctgaggaa     1560

ggaccatcaa gaaaagatgg aaataaagtg gatgtggtgg gtgccacaca aggccaagct     1620

ggaagctgca gccgtggtcc cggggatgga gggagcagag accactggaa ggacttggat     1680

aggaaggatg gcaaaaaaga tcaagactcc agatctgcgc ctgagccaaa gaaacctgag     1740

gagaacccag cctctaagtt cagctctgca agcaagtacg ctgctctgtc tgtggatggc     1800

gaggatgagg atgagggcga cgactgcact gagtag                               1836


<210>  24
<211>  611
<212>  PRT
<213>  Mus musculus

<400>  24

Met Ala Ala Ser Ala Lys Lys Lys Asn Lys Lys Gly Lys Thr Ile Ser 
1               5                   10                  15      


Leu Thr Asp Phe Leu Ala Glu Asp Gly Gly Thr Gly Gly Gly Ser Thr 
            20                  25                  30          


Tyr Val Pro Lys Pro Val Ser Trp Ala Asp Glu Thr Asp Asp Leu Glu 
        35                  40                  45              


Gly Asp Val Ser Thr Thr Trp His Ser Asn Asp Asp Asp Val Tyr Arg 
    50                  55                  60                  


Ala Pro Pro Ile Asp Arg Ser Ile Leu Pro Thr Ala Pro Arg Ala Ala 
65                  70                  75                  80  


Arg Glu Pro Asn Ile Asp Arg Ser Arg Leu Pro Lys Ser Pro Pro Tyr 
                85                  90                  95      


Thr Ala Phe Leu Gly Asn Leu Pro Tyr Asp Val Thr Glu Asp Ser Ile 
            100                 105                 110         


Lys Asp Phe Phe Arg Gly Leu Asn Ile Ser Ala Val Arg Leu Pro Arg 
        115                 120                 125             


Glu Pro Ser Asn Pro Asp Arg Leu Lys Gly Phe Gly Tyr Ala Glu Phe 
    130                 135                 140                 


Glu Asp Leu Asp Ser Leu Leu Ser Ala Leu Ser Leu Asn Glu Glu Ser 
145                 150                 155                 160 


Leu Gly Asn Arg Arg Ile Arg Val Asp Val Ala Asp Gln Ala Gln Asp 
                165                 170                 175     


Lys Asp Arg Asp Asp Arg Ser Phe Gly Arg Asp Arg Asn Arg Asp Ser 
            180                 185                 190         


Asp Lys Thr Asp Thr Asp Trp Arg Ala Arg Pro Thr Thr Asp Ser Phe 
        195                 200                 205             


Asp Asp Tyr Pro Pro Arg Arg Gly Asp Asp Ser Phe Gly Asp Lys Tyr 
    210                 215                 220                 


Arg Asp Arg Tyr Asp Ser Asp Arg Tyr Arg Asp Gly Tyr Arg Asp Gly 
225                 230                 235                 240 


Tyr Arg Asp Gly Pro Arg Arg Asp Met Asp Arg Tyr Gly Gly Arg Asp 
                245                 250                 255     


Arg Tyr Asp Asp Arg Gly Ser Arg Asp Tyr Asp Arg Gly Tyr Asp Ser 
            260                 265                 270         


Arg Ile Gly Ser Gly Arg Arg Ala Phe Gly Ser Gly Tyr Arg Arg Asp 
        275                 280                 285             


Asp Asp Tyr Arg Gly Gly Gly Asp Arg Tyr Glu Asp Arg Tyr Asp Arg 
    290                 295                 300                 


Arg Asp Asp Arg Ser Trp Ser Ser Arg Asp Asp Tyr Ser Arg Asp Asp 
305                 310                 315                 320 


Tyr Arg Arg Asp Asp Arg Gly Pro Pro Gln Arg Pro Arg Leu Asn Leu 
                325                 330                 335     


Lys Pro Arg Ser Ala Pro Lys Glu Asp Asp Ala Ser Ala Ser Thr Ser 
            340                 345                 350         


Gln Ser Ser Arg Ala Ala Ser Ile Phe Gly Gly Ala Lys Pro Val Asp 
        355                 360                 365             


Thr Ala Ala Arg Glu Arg Glu Val Glu Glu Arg Leu Gln Lys Glu Gln 
    370                 375                 380                 


Glu Lys Leu Gln Arg Gln Leu Asp Glu Pro Lys Leu Asp Arg Arg Pro 
385                 390                 395                 400 


Arg Glu Arg His Pro Ser Trp Arg Ser Glu Glu Thr Gln Glu Arg Glu 
                405                 410                 415     


Arg Ser Arg Thr Gly Ser Glu Ser Ser Gln Thr Gly Ala Ser Ala Thr 
            420                 425                 430         


Ser Gly Arg Asn Thr Arg Arg Arg Glu Ser Glu Lys Ser Leu Glu Asn 
        435                 440                 445             


Glu Thr Leu Asn Lys Glu Glu Asp Cys His Ser Pro Thr Ser Lys Pro 
    450                 455                 460                 


Pro Lys Pro Asp Gln Pro Leu Lys Val Met Pro Ala Pro Pro Pro Lys 
465                 470                 475                 480 


Glu Asn Ala Trp Val Lys Arg Ser Ser Asn Pro Pro Ala Arg Ser Gln 
                485                 490                 495     


Ser Ser Asp Thr Glu Gln Pro Ser Pro Thr Ser Gly Gly Gly Lys Val 
            500                 505                 510         


Ala Ala Val Gln Pro Pro Glu Glu Gly Pro Ser Arg Lys Asp Gly Asn 
        515                 520                 525             


Lys Val Asp Val Val Gly Ala Thr Gln Gly Gln Ala Gly Ser Cys Ser 
    530                 535                 540                 


Arg Gly Pro Gly Asp Gly Gly Ser Arg Asp His Trp Lys Asp Leu Asp 
545                 550                 555                 560 


Arg Lys Asp Gly Lys Lys Asp Gln Asp Ser Arg Ser Ala Pro Glu Pro 
                565                 570                 575     


Lys Lys Pro Glu Glu Asn Pro Ala Ser Lys Phe Ser Ser Ala Ser Lys 
            580                 585                 590         


Tyr Ala Ala Leu Ser Val Asp Gly Glu Asp Glu Asp Glu Gly Asp Asp 
        595                 600                 605             


Cys Thr Glu 
    610     


<210>  25
<211>  2090
<212>  DNA
<213>  Macaca mulatta

<400>  25
ctctcccaac atggcggcct cagcaaaaaa gaagaataag aaggggaaga ctatctccct       60

aacagacttt ctggctgagg atgggggtac tggtggagga agcacctatg tttccaaacc      120

agtcagctgg gctgatgaaa cggatgacct ggaaggagat gtttcaacaa cgtggcacag      180

taatgacgac gatgtgtaca gggcgcctcc aattgaccgt tccatccttc ccactgctcc      240

acgggctgct cgggaaccca atatcgaccg gagccgtctt cccaaatcgc caccctacac      300

tgcttttcta gggaacctac cctatgatgt gacagaagaa tcaattaagg aattctttag      360

aggattaaat atcagtgcag tgcgtttacc acgtgaaccc agcaatccag agaggttgaa      420

aggttttggt tatgctgaat ttgaggacct ggattccctg ctcagtgccc tgagtctcaa      480

tgaagagtct ctaggtaaca ggagaattcg agtggacgtt gctgatcaag cacaggataa      540

agacagggat gatcgttctt ttggccgtga tagaaatcgg gattctgaca aaacagatac      600

agactggagg gctcgtcctg ctacagacag ctttgatgac tacccaccta gaagaggtga      660

tgatagcttt ggagacaagt atcgagatcg ttatgattca gaccggtatc gggatgggta      720

tcgggatggc ccacgccggg atatggatcg atatggtggc cgggatcgct atgatgaccg      780

aggcagcaga gactatgata gaggctatga ttcccggata ggcagtggca gaagagcatt      840

tggcagtggg tatcgcaggg atgatgacta cagaggaggc ggggaccgat atgaagaccg      900

atacgacaga cgggatgatc ggtcgtggag ctccagagat gattactctc gggatgatta      960

taggcgcgat gacagaggtc cccctcaaag acccaaactg aatctaaagc ctcggagtac     1020

tcctaaggaa gatgattcct ctgctagtac ctcccagtcc agtcgagctg cttctatctt     1080

tggaggggca aagcctgttg acacagctgc tagagaaaga gaagtagaag aacggctaca     1140

gaaggaacaa gagaagttgc agcgtcagct ggatgagcca aaactagaac gacggcctcg     1200

ggagagacac ccaagctggc gaagtgaaga aactcaggaa cgggaacggt cgaggacagg     1260

aagtgagtca tcacagactg ggacctccgc cacatctggc agaaatgcac gaaggagaga     1320

gagtgagaag tctctagaaa atgaaacact caataaggag gaagattgtc actctccaac     1380

ttctaaacct cccaaacctg atcagcccct aaaggtaatg ccagcccctc caccaaagga     1440

gaatgcttgg gtgaagcgaa gttctaaccc tccagctcga tctcagagct cagacacaga     1500

gcagcaatcc cctacaagtg gtgggggaaa agtagctcca gctcaaccat ctgaggaagg     1560

accagcaagg aaagatgaaa ataaagtaga tgggatgaat gtcccaaaag gccaaactgg     1620

gacctctagc cgtggaccag gagacggagg gaacaaagac cactggaagg agtcagatag     1680

gaaagatggc aaaaaggatc aagactccag atctgcacct gagccaaaga aacctgagga     1740

aaatccagct tcgaagttca gttctgcaag caagtatgct gctctctctg ttgatggtga     1800

agatgaaaac gagggagaag attatgccga atagacctct acatcctgtg ctttctccta     1860

gtttctctcc accctggaac attcgagagc aaatcaaaac ctctatccag acaagacaaa     1920

ataaaactca ccatctcctg aagacctttc ttaccttttt ttaaaaacaa aaaatgaaat     1980

tattttgcat gctgctgcag cctttaaagt attaaagtaa ctggagaatc gccaatatag     2040

ccagagagaa agggactaca gctttttaga ggaagagttg tggtgtgtta                2090


<210>  26
<211>  607
<212>  PRT
<213>  Macaca mulatta

<400>  26

Met Ala Ala Ser Ala Lys Lys Lys Asn Lys Lys Gly Lys Thr Ile Ser 
1               5                   10                  15      


Leu Thr Asp Phe Leu Ala Glu Asp Gly Gly Thr Gly Gly Gly Ser Thr 
            20                  25                  30          


Tyr Val Ser Lys Pro Val Ser Trp Ala Asp Glu Thr Asp Asp Leu Glu 
        35                  40                  45              


Gly Asp Val Ser Thr Thr Trp His Ser Asn Asp Asp Asp Val Tyr Arg 
    50                  55                  60                  


Ala Pro Pro Ile Asp Arg Ser Ile Leu Pro Thr Ala Pro Arg Ala Ala 
65                  70                  75                  80  


Arg Glu Pro Asn Ile Asp Arg Ser Arg Leu Pro Lys Ser Pro Pro Tyr 
                85                  90                  95      


Thr Ala Phe Leu Gly Asn Leu Pro Tyr Asp Val Thr Glu Glu Ser Ile 
            100                 105                 110         


Lys Glu Phe Phe Arg Gly Leu Asn Ile Ser Ala Val Arg Leu Pro Arg 
        115                 120                 125             


Glu Pro Ser Asn Pro Glu Arg Leu Lys Gly Phe Gly Tyr Ala Glu Phe 
    130                 135                 140                 


Glu Asp Leu Asp Ser Leu Leu Ser Ala Leu Ser Leu Asn Glu Glu Ser 
145                 150                 155                 160 


Leu Gly Asn Arg Arg Ile Arg Val Asp Val Ala Asp Gln Ala Gln Asp 
                165                 170                 175     


Lys Asp Arg Asp Asp Arg Ser Phe Gly Arg Asp Arg Asn Arg Asp Ser 
            180                 185                 190         


Asp Lys Thr Asp Thr Asp Trp Arg Ala Arg Pro Ala Thr Asp Ser Phe 
        195                 200                 205             


Asp Asp Tyr Pro Pro Arg Arg Gly Asp Asp Ser Phe Gly Asp Lys Tyr 
    210                 215                 220                 


Arg Asp Arg Tyr Asp Ser Asp Arg Tyr Arg Asp Gly Tyr Arg Asp Gly 
225                 230                 235                 240 


Pro Arg Arg Asp Met Asp Arg Tyr Gly Gly Arg Asp Arg Tyr Asp Asp 
                245                 250                 255     


Arg Gly Ser Arg Asp Tyr Asp Arg Gly Tyr Asp Ser Arg Ile Gly Ser 
            260                 265                 270         


Gly Arg Arg Ala Phe Gly Ser Gly Tyr Arg Arg Asp Asp Asp Tyr Arg 
        275                 280                 285             


Gly Gly Gly Asp Arg Tyr Glu Asp Arg Tyr Asp Arg Arg Asp Asp Arg 
    290                 295                 300                 


Ser Trp Ser Ser Arg Asp Asp Tyr Ser Arg Asp Asp Tyr Arg Arg Asp 
305                 310                 315                 320 


Asp Arg Gly Pro Pro Gln Arg Pro Lys Leu Asn Leu Lys Pro Arg Ser 
                325                 330                 335     


Thr Pro Lys Glu Asp Asp Ser Ser Ala Ser Thr Ser Gln Ser Ser Arg 
            340                 345                 350         


Ala Ala Ser Ile Phe Gly Gly Ala Lys Pro Val Asp Thr Ala Ala Arg 
        355                 360                 365             


Glu Arg Glu Val Glu Glu Arg Leu Gln Lys Glu Gln Glu Lys Leu Gln 
    370                 375                 380                 


Arg Gln Leu Asp Glu Pro Lys Leu Glu Arg Arg Pro Arg Glu Arg His 
385                 390                 395                 400 


Pro Ser Trp Arg Ser Glu Glu Thr Gln Glu Arg Glu Arg Ser Arg Thr 
                405                 410                 415     


Gly Ser Glu Ser Ser Gln Thr Gly Thr Ser Ala Thr Ser Gly Arg Asn 
            420                 425                 430         


Ala Arg Arg Arg Glu Ser Glu Lys Ser Leu Glu Asn Glu Thr Leu Asn 
        435                 440                 445             


Lys Glu Glu Asp Cys His Ser Pro Thr Ser Lys Pro Pro Lys Pro Asp 
    450                 455                 460                 


Gln Pro Leu Lys Val Met Pro Ala Pro Pro Pro Lys Glu Asn Ala Trp 
465                 470                 475                 480 


Val Lys Arg Ser Ser Asn Pro Pro Ala Arg Ser Gln Ser Ser Asp Thr 
                485                 490                 495     


Glu Gln Gln Ser Pro Thr Ser Gly Gly Gly Lys Val Ala Pro Ala Gln 
            500                 505                 510         


Pro Ser Glu Glu Gly Pro Ala Arg Lys Asp Glu Asn Lys Val Asp Gly 
        515                 520                 525             


Met Asn Val Pro Lys Gly Gln Thr Gly Thr Ser Ser Arg Gly Pro Gly 
    530                 535                 540                 


Asp Gly Gly Asn Lys Asp His Trp Lys Glu Ser Asp Arg Lys Asp Gly 
545                 550                 555                 560 


Lys Lys Asp Gln Asp Ser Arg Ser Ala Pro Glu Pro Lys Lys Pro Glu 
                565                 570                 575     


Glu Asn Pro Ala Ser Lys Phe Ser Ser Ala Ser Lys Tyr Ala Ala Leu 
            580                 585                 590         


Ser Val Asp Gly Glu Asp Glu Asn Glu Gly Glu Asp Tyr Ala Glu 
        595                 600                 605         


<210>  27
<211>  1833
<212>  DNA
<213>  Bos taurus

<400>  27
atggcggcct cagcgaaaaa gaagaataag aaggggaaga ctatctccct aacagacttt       60

ctggctgagg atggagggac tggtggaggc agcacctatg tccccaaacc agtcagctgg      120

gctgatgaaa cagacgatct ggaaggggat gtttcaacca cttggcatag taatgatgat      180

gatgtgtatc gggcacctcc aattgaccgt tccatcctgc ccactgctcc acgggctgct      240

cgggaaccca atatcgaccg gagccgtctt cccaaatctc caccctacac tgcttttcta      300

gggaacctgc cctatgatgt gacagaagac tccattaagg aattctttag aggattaaat      360

atcagtgcag tgcgtttacc gcgtgaaccc agcaatcctg agaggttaaa aggttttggt      420

tatgcagagt ttgaggacct ggattccttg ctcagtgcct tgagcctcaa cgaagagtct      480

ctaggtaaca ggagaattcg agtggacgtt gctgatcaag cacaggataa agacagggat      540

gatcgttctt ttggccgaga tagaaatcgt gattctgaca aaacagatac agactggagg      600

gcccgtcctg ctgcagacag ctttgatgac tacccgccca gaaggggtga tgatagcttt      660

ggagacaagt atcgagatcg ttacgattca gacagatatc gtgatgggta tcgggacagt      720

taccgtgatg gcccacgccg ggacatggat cgatacgggg gccgagatcg ctatgatgac      780

cgaggtggca gagactatga cagaggctac gattccagga taggcagtgg cagaagagca      840

ttcggtagcg ggtaccggag ggatgatgac tacagaggag gcggggaccg ctatgaagac      900

agatacgaca gacgagatga ccggtcctgg agttccagag atgattactc tcgggatgat      960

tacaggcggg atgatagagg tccccctcaa agacccaaac tgaacctaaa gcctcggagt     1020

actcctaagg aagatgattc ctccgctagc acctcccagt ccagtcgtgc agcctctatc     1080

tttggagggg caaagcctgt tgacacagct gctagagaac gagaagtaga agagcggcta     1140

cagaaggaac aggagaaact gcagcgtcag ctggatgagc caaaactaga acgacggcct     1200

cgggagagac acccaagctg gcgaagtgaa gaaactcagg aacgggaacg atcgaggaca     1260

ggaagtgagt catcacagac tgggacctca gccacatctg gcagaaatgc aagaagaaga     1320

gagagtgaga agtctttaga aaatgaaacc cccaataaag aggaagactg tcagtctcca     1380

acttctaagc ctcccaaacc tgaacagcct ctaaaggtaa tgccagcccc tccaccaaag     1440

gagaatgctt gggtgaagcg aagttctaac cctcctgctc gatctcagag ctcagacaca     1500

gagcagcagt cccctacaag tggtggaggg aaagtagttc cagctcaact atctgaggaa     1560

ggatcagcaa ggaaagatga aaataaagta gatggggtga gtgccccaaa aggccaaagt     1620

gggagctcca gccgtggtcc gggagatggg gggaacaaag accactggaa ggaggcagac     1680

aggaaagatg gcaaaaagga tcacgactcc agatctgcac ctgagccaaa gaaagctgaa     1740

gaaaatccag cctcgaagtt cagatctgca agcaagtacg ctactctcgc cattgacggt     1800

gaagatgaaa atgagggaga ttacaccgaa tag                                  1833


<210>  28
<211>  610
<212>  PRT
<213>  Bos taurus

<400>  28

Met Ala Ala Ser Ala Lys Lys Lys Asn Lys Lys Gly Lys Thr Ile Ser 
1               5                   10                  15      


Leu Thr Asp Phe Leu Ala Glu Asp Gly Gly Thr Gly Gly Gly Ser Thr 
            20                  25                  30          


Tyr Val Pro Lys Pro Val Ser Trp Ala Asp Glu Thr Asp Asp Leu Glu 
        35                  40                  45              


Gly Asp Val Ser Thr Thr Trp His Ser Asn Asp Asp Asp Val Tyr Arg 
    50                  55                  60                  


Ala Pro Pro Ile Asp Arg Ser Ile Leu Pro Thr Ala Pro Arg Ala Ala 
65                  70                  75                  80  


Arg Glu Pro Asn Ile Asp Arg Ser Arg Leu Pro Lys Ser Pro Pro Tyr 
                85                  90                  95      


Thr Ala Phe Leu Gly Asn Leu Pro Tyr Asp Val Thr Glu Asp Ser Ile 
            100                 105                 110         


Lys Glu Phe Phe Arg Gly Leu Asn Ile Ser Ala Val Arg Leu Pro Arg 
        115                 120                 125             


Glu Pro Ser Asn Pro Glu Arg Leu Lys Gly Phe Gly Tyr Ala Glu Phe 
    130                 135                 140                 


Glu Asp Leu Asp Ser Leu Leu Ser Ala Leu Ser Leu Asn Glu Glu Ser 
145                 150                 155                 160 


Leu Gly Asn Arg Arg Ile Arg Val Asp Val Ala Asp Gln Ala Gln Asp 
                165                 170                 175     


Lys Asp Arg Asp Asp Arg Ser Phe Gly Arg Asp Arg Asn Arg Asp Ser 
            180                 185                 190         


Asp Lys Thr Asp Thr Asp Trp Arg Ala Arg Pro Ala Ala Asp Ser Phe 
        195                 200                 205             


Asp Asp Tyr Pro Pro Arg Arg Gly Asp Asp Ser Phe Gly Asp Lys Tyr 
    210                 215                 220                 


Arg Asp Arg Tyr Asp Ser Asp Arg Tyr Arg Asp Gly Tyr Arg Asp Ser 
225                 230                 235                 240 


Tyr Arg Asp Gly Pro Arg Arg Asp Met Asp Arg Tyr Gly Gly Arg Asp 
                245                 250                 255     


Arg Tyr Asp Asp Arg Gly Gly Arg Asp Tyr Asp Arg Gly Tyr Asp Ser 
            260                 265                 270         


Arg Ile Gly Ser Gly Arg Arg Ala Phe Gly Ser Gly Tyr Arg Arg Asp 
        275                 280                 285             


Asp Asp Tyr Arg Gly Gly Gly Asp Arg Tyr Glu Asp Arg Tyr Asp Arg 
    290                 295                 300                 


Arg Asp Asp Arg Ser Trp Ser Ser Arg Asp Asp Tyr Ser Arg Asp Asp 
305                 310                 315                 320 


Tyr Arg Arg Asp Asp Arg Gly Pro Pro Gln Arg Pro Lys Leu Asn Leu 
                325                 330                 335     


Lys Pro Arg Ser Thr Pro Lys Glu Asp Asp Ser Ser Ala Ser Thr Ser 
            340                 345                 350         


Gln Ser Ser Arg Ala Ala Ser Ile Phe Gly Gly Ala Lys Pro Val Asp 
        355                 360                 365             


Thr Ala Ala Arg Glu Arg Glu Val Glu Glu Arg Leu Gln Lys Glu Gln 
    370                 375                 380                 


Glu Lys Leu Gln Arg Gln Leu Asp Glu Pro Lys Leu Glu Arg Arg Pro 
385                 390                 395                 400 


Arg Glu Arg His Pro Ser Trp Arg Ser Glu Glu Thr Gln Glu Arg Glu 
                405                 410                 415     


Arg Ser Arg Thr Gly Ser Glu Ser Ser Gln Thr Gly Thr Ser Ala Thr 
            420                 425                 430         


Ser Gly Arg Asn Ala Arg Arg Arg Glu Ser Glu Lys Ser Leu Glu Asn 
        435                 440                 445             


Glu Thr Pro Asn Lys Glu Glu Asp Cys Gln Ser Pro Thr Ser Lys Pro 
    450                 455                 460                 


Pro Lys Pro Glu Gln Pro Leu Lys Val Met Pro Ala Pro Pro Pro Lys 
465                 470                 475                 480 


Glu Asn Ala Trp Val Lys Arg Ser Ser Asn Pro Pro Ala Arg Ser Gln 
                485                 490                 495     


Ser Ser Asp Thr Glu Gln Gln Ser Pro Thr Ser Gly Gly Gly Lys Val 
            500                 505                 510         


Val Pro Ala Gln Leu Ser Glu Glu Gly Ser Ala Arg Lys Asp Glu Asn 
        515                 520                 525             


Lys Val Asp Gly Val Ser Ala Pro Lys Gly Gln Ser Gly Ser Ser Ser 
    530                 535                 540                 


Arg Gly Pro Gly Asp Gly Gly Asn Lys Asp His Trp Lys Glu Ala Asp 
545                 550                 555                 560 


Arg Lys Asp Gly Lys Lys Asp His Asp Ser Arg Ser Ala Pro Glu Pro 
                565                 570                 575     


Lys Lys Ala Glu Glu Asn Pro Ala Ser Lys Phe Arg Ser Ala Ser Lys 
            580                 585                 590         


Tyr Ala Thr Leu Ala Ile Asp Gly Glu Asp Glu Asn Glu Gly Asp Tyr 
        595                 600                 605             


Thr Glu 
    610 


<210>  29
<211>  1836
<212>  DNA
<213>  Rattus norvegicus

<400>  29
atggcggcct cagcaaaaaa gaagaataag aaggggaaga ccatctccct aacagacttt       60

ctagctgagg atgggggaac tggtggagga agcacctatg tccccaaacc agtcagctgg      120

gctgatgaaa cagacgatct ggaaggagat gtgtcaacaa cttggcatag taacgatgac      180

gatgtgtaca gggcacctcc tattgaccgt tccatccttc ccactgctcc acgggctgct      240

cgggaaccca atattgatcg gagccgtctt cccaagtcac caccctacac tgctttccta      300

gggaatctgc cctatgatgt gacagaagac tctattaagg atttctttag aggattaaat      360

atcagcgctg tacgcttgcc gcgtgagccc agcaatccag acaggttgaa aggttttggc      420

tatgccgaat ttgaggatct ggattctctg ctcagtgctc tgagtctcaa tgaagagtct      480

ctaggtaaca ggagaattcg ggtggatgtt gctgatcaag cacaggataa agacagggat      540

gaccgttctt ttggtcgaga tagaaatcgg gattctgaca agacagacac agactggagg      600

gcccgtcctg ccacagacag ctttgatgac tacccaccta gacgaggtga tgacagcttc      660

ggagacaagt atcgagatcg ttacgagtca gaccggtatc gggatgggta tagggacgga      720

tatcgggacg gcccacgcag agacatggac cgctatgggg gccgggatcg ctatgatgac      780

cgaggcagca gagactatga ccgaggctat gactccagga taggcagtgg cagaagagca      840

tttggaagtg ggtaccggag ggatgacgac tacagaggag gtggggaccg ctatgaagat      900

cgctatgaca gacgggacga tcggtcatgg agctccaggg acgattactc tcgggacgat      960

tacaggcgtg atgacagagg tcccccccaa agacccaaac tgaatctaaa gcctcggagt     1020

actcctaaag aagatgattc ctctgctagc acctcccagt ccagccgagc ggcttctatc     1080

tttggagggg cgaagcctgt tgacacagct gctagagaaa gagaagtaga ggagcggcta     1140

cagaaggagc aggagaagct gcagcgtcag ctggatgagc caaaactaga ccgccggccc     1200

cgggagagac acccaagttg gcgaagtgaa gaaactcagg aaagagaacg gtcgaggaca     1260

ggaagtgagt catcgcagac tgggacctca gccacatctg gcagaaatac acgaaggaga     1320

gagagtgaga agtctctaga aaatgaaacc ctcaataaag aagaagactg tcactctcca     1380

acctctaagc ctcctaaacc tgaccagcct ctaaaggtaa tgccagcccc tccaccaaag     1440

gagaatgcgt gggtgaagcg aagctctaac cctcctgctc gatctcagag ctcagacaca     1500

gagcagccgt cccctacaag tggtggaggg aaagttgctc cagctcagcc ctctgaggaa     1560

ggaccatcaa ggaaagatga aactaaagtg gatggggtga gcaccaccaa aggccagact     1620

ggacactcca gccgtggtcc tggggatgga gggagcagag accactggaa ggagttggat     1680

aggaaggacg gcaaaaaaga tcaagactcc agatctgcac ctgagccaaa gaaatctgag     1740

gagaaccgag cctctaagtt cagttctgca agcaagtacg ctgctctgtc tgtggacggt     1800

gaggatgagg atgagggaga cgactgcact gagtag                               1836


<210>  30
<211>  611
<212>  PRT
<213>  Rattus norvegicus

<400>  30

Met Ala Ala Ser Ala Lys Lys Lys Asn Lys Lys Gly Lys Thr Ile Ser 
1               5                   10                  15      


Leu Thr Asp Phe Leu Ala Glu Asp Gly Gly Thr Gly Gly Gly Ser Thr 
            20                  25                  30          


Tyr Val Pro Lys Pro Val Ser Trp Ala Asp Glu Thr Asp Asp Leu Glu 
        35                  40                  45              


Gly Asp Val Ser Thr Thr Trp His Ser Asn Asp Asp Asp Val Tyr Arg 
    50                  55                  60                  


Ala Pro Pro Ile Asp Arg Ser Ile Leu Pro Thr Ala Pro Arg Ala Ala 
65                  70                  75                  80  


Arg Glu Pro Asn Ile Asp Arg Ser Arg Leu Pro Lys Ser Pro Pro Tyr 
                85                  90                  95      


Thr Ala Phe Leu Gly Asn Leu Pro Tyr Asp Val Thr Glu Asp Ser Ile 
            100                 105                 110         


Lys Asp Phe Phe Arg Gly Leu Asn Ile Ser Ala Val Arg Leu Pro Arg 
        115                 120                 125             


Glu Pro Ser Asn Pro Asp Arg Leu Lys Gly Phe Gly Tyr Ala Glu Phe 
    130                 135                 140                 


Glu Asp Leu Asp Ser Leu Leu Ser Ala Leu Ser Leu Asn Glu Glu Ser 
145                 150                 155                 160 


Leu Gly Asn Arg Arg Ile Arg Val Asp Val Ala Asp Gln Ala Gln Asp 
                165                 170                 175     


Lys Asp Arg Asp Asp Arg Ser Phe Gly Arg Asp Arg Asn Arg Asp Ser 
            180                 185                 190         


Asp Lys Thr Asp Thr Asp Trp Arg Ala Arg Pro Ala Thr Asp Ser Phe 
        195                 200                 205             


Asp Asp Tyr Pro Pro Arg Arg Gly Asp Asp Ser Phe Gly Asp Lys Tyr 
    210                 215                 220                 


Arg Asp Arg Tyr Glu Ser Asp Arg Tyr Arg Asp Gly Tyr Arg Asp Gly 
225                 230                 235                 240 


Tyr Arg Asp Gly Pro Arg Arg Asp Met Asp Arg Tyr Gly Gly Arg Asp 
                245                 250                 255     


Arg Tyr Asp Asp Arg Gly Ser Arg Asp Tyr Asp Arg Gly Tyr Asp Ser 
            260                 265                 270         


Arg Ile Gly Ser Gly Arg Arg Ala Phe Gly Ser Gly Tyr Arg Arg Asp 
        275                 280                 285             


Asp Asp Tyr Arg Gly Gly Gly Asp Arg Tyr Glu Asp Arg Tyr Asp Arg 
    290                 295                 300                 


Arg Asp Asp Arg Ser Trp Ser Ser Arg Asp Asp Tyr Ser Arg Asp Asp 
305                 310                 315                 320 


Tyr Arg Arg Asp Asp Arg Gly Pro Pro Gln Arg Pro Lys Leu Asn Leu 
                325                 330                 335     


Lys Pro Arg Ser Thr Pro Lys Glu Asp Asp Ser Ser Ala Ser Thr Ser 
            340                 345                 350         


Gln Ser Ser Arg Ala Ala Ser Ile Phe Gly Gly Ala Lys Pro Val Asp 
        355                 360                 365             


Thr Ala Ala Arg Glu Arg Glu Val Glu Glu Arg Leu Gln Lys Glu Gln 
    370                 375                 380                 


Glu Lys Leu Gln Arg Gln Leu Asp Glu Pro Lys Leu Asp Arg Arg Pro 
385                 390                 395                 400 


Arg Glu Arg His Pro Ser Trp Arg Ser Glu Glu Thr Gln Glu Arg Glu 
                405                 410                 415     


Arg Ser Arg Thr Gly Ser Glu Ser Ser Gln Thr Gly Thr Ser Ala Thr 
            420                 425                 430         


Ser Gly Arg Asn Thr Arg Arg Arg Glu Ser Glu Lys Ser Leu Glu Asn 
        435                 440                 445             


Glu Thr Leu Asn Lys Glu Glu Asp Cys His Ser Pro Thr Ser Lys Pro 
    450                 455                 460                 


Pro Lys Pro Asp Gln Pro Leu Lys Val Met Pro Ala Pro Pro Pro Lys 
465                 470                 475                 480 


Glu Asn Ala Trp Val Lys Arg Ser Ser Asn Pro Pro Ala Arg Ser Gln 
                485                 490                 495     


Ser Ser Asp Thr Glu Gln Pro Ser Pro Thr Ser Gly Gly Gly Lys Val 
            500                 505                 510         


Ala Pro Ala Gln Pro Ser Glu Glu Gly Pro Ser Arg Lys Asp Glu Thr 
        515                 520                 525             


Lys Val Asp Gly Val Ser Thr Thr Lys Gly Gln Thr Gly His Ser Ser 
    530                 535                 540                 


Arg Gly Pro Gly Asp Gly Gly Ser Arg Asp His Trp Lys Glu Leu Asp 
545                 550                 555                 560 


Arg Lys Asp Gly Lys Lys Asp Gln Asp Ser Arg Ser Ala Pro Glu Pro 
                565                 570                 575     


Lys Lys Ser Glu Glu Asn Arg Ala Ser Lys Phe Ser Ser Ala Ser Lys 
            580                 585                 590         


Tyr Ala Ala Leu Ser Val Asp Gly Glu Asp Glu Asp Glu Gly Asp Asp 
        595                 600                 605             


Cys Thr Glu 
    610     


<210>  31
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: sh-eIF4A #1 shRNA 
       target sequence"

<400>  31
gccgtgtgtt tgatatgctt a                                                 21


<210>  32
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: sh-eIF4A #2 shRNA 
       target sequence"

<400>  32
gccgtaaagg tgtggctatt a                                                 21


<210>  33
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: sh-eIF4A #3 shRNA 
       target sequence"

<400>  33
ccttgtatca agggttatga t                                                 21


<210>  34
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: sh-eIF4A #4 shRNA 
       target sequence"

<400>  34
cgaaatgtta agccgtggat t                                                 21


<210>  35
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: sh-eIF4A #5 shRNA 
       target sequence"

<400>  35
gcagcaggtt tctttagtca t                                                 21


<210>  36
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: sh-eIF4B #1 shRNA 
       target sequence"

<400>  36
gcggagaaac accttgatct t                                                 21


<210>  37
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: sh-eIF4B #2 shRNA 
       target sequence"

<400>  37
gccgtgatag aaatcgggat t                                                 21


<210>  38
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: sh-eIF4B #3 shRNA 
       target sequence"

<400>  38
ccaacttcta aacctcccaa a                                                 21


<210>  39
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: sh-eIF4B #4 shRNA 
       target sequence"

<400>  39
ctaccctatg atgttacaga a                                                 21


<210>  40
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: sh-eIF4B #5 shRNA 
       target sequence"

<400>  40
cgggatgatt ataggcgtga t                                                 21


<210>  41
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  41
acccccgagc tgtgctgctc g                                                 21


<210>  42
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  42
cgtcgcggga ggctgctggt t                                                 21


<210>  43
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  43
ctaccctctc aacgacagca                                                   20


<210>  44
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  44
agagcagaga atccgaggac                                                   20


<210>  45
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  45
gtgctgcatg aggagacacc                                                   20


<210>  46
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  46
tttgcctctt ctccacagac a                                                 21


