                         SEQUENCE LISTING

<110>  Albany Medical College
       University of Washington
 
<120>  MULTI-FUNCTIONAL MUCOSAL VACCINE PLATFORM

<130>  AMC-002PCT1

<150>  61/938,607
<151>  2014-02-11

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  29
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  1
ataagcgctg gaggcggagg ttctagtga                                         29


<210>  2
<211>  34
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  2
agaattcgct agcagtcgag cctcccccac cggt                                   34


<210>  3
<211>  29
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  3
agaattcatg gaagaatctc ccgtagcca                                         29


<210>  4
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  4
ataagcgctg gtcgagcctc ccccaccggt                                        30


<210>  5
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  5
tgctagcgga ggcggaggtt ctagtga                                           27


<210>  6
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  6
agaattcagt cgagcctccc ccaccggt                                          28


<210>  7
<211>  29
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  7
atcgtacgca ccaccaccac caccactga                                         29


<210>  8
<211>  54
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  8
atcgtacgtg tacaaccgcc tgatccaccc tcgagttctg gggctggagt ttct             54


<210>  9
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  9
tgtacactag agaagtgctg tgccgct                                           27


<210>  10
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  10
cgtacgtaag cctaaggcag cttgactt                                          28


<210>  11
<211>  1122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Trivalent Anti-FcgRI---PspA

<400>  11

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Val 
        35                  40                  45              


Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu 
65                  70                  75                  80  


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr 
            100                 105                 110         


Cys His Gln Tyr Leu Ser Ser Trp Thr Phe Gly Gln Gly Thr Lys Val 
        115                 120                 125             


Glu Ile Lys Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
145                 150                 155                 160 


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ser Ser Ser Gly Phe Ile 
                165                 170                 175     


Phe Ser Asp Asn Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly 
            180                 185                 190         


Leu Glu Trp Val Ala Thr Ile Ser Asp Gly Gly Ser Tyr Thr Tyr Tyr 
        195                 200                 205             


Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
    210                 215                 220                 


Asn Thr Leu Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly 
225                 230                 235                 240 


Val Tyr Phe Cys Ala Arg Gly Tyr Tyr Arg Tyr Glu Gly Ala Met Asp 
                245                 250                 255     


Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser Gly Ser Thr Gly 
            260                 265                 270         


Gly Gly Gly Ser Thr Ser Ala Gly Gly Gly Gly Ser Ser Asp Ile Gln 
        275                 280                 285             


Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
    290                 295                 300                 


Thr Ile Thr Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Gln 
305                 310                 315                 320 


Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
                325                 330                 335     


Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Ser Arg 
            340                 345                 350         


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser 
        355                 360                 365             


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys His Gln Tyr Leu Ser 
    370                 375                 380                 


Ser Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ser Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
                405                 410                 415     


Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu 
            420                 425                 430         


Arg Leu Ser Cys Ser Ser Ser Gly Phe Ile Phe Ser Asp Asn Tyr Met 
        435                 440                 445             


Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Thr 
    450                 455                 460                 


Ile Ser Asp Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val Lys Gly 
465                 470                 475                 480 


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe Leu Gln 
                485                 490                 495     


Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys Ala Arg 
            500                 505                 510         


Gly Tyr Tyr Arg Tyr Glu Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr 
        515                 520                 525             


Pro Val Thr Val Ser Ser Gly Ser Thr Gly Gly Gly Gly Ser Thr Ala 
    530                 535                 540                 


Ser Gly Gly Gly Gly Ser Ser Asp Ile Gln Leu Thr Gln Ser Pro Ser 
545                 550                 555                 560 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ser 
                565                 570                 575     


Ser Gln Ser Val Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp 
            580                 585                 590         


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Trp Ala 
        595                 600                 605             


Ser Thr Arg Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
    610                 615                 620                 


Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile 
625                 630                 635                 640 


Ala Thr Tyr Tyr Cys His Gln Tyr Leu Ser Ser Trp Thr Phe Gly Gln 
                645                 650                 655     


Gly Thr Lys Val Glu Ile Lys Ser Ser Gly Gly Gly Gly Ser Gly Gly 
            660                 665                 670         


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
        675                 680                 685             


Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ser Ser 
    690                 695                 700                 


Ser Gly Phe Ile Phe Ser Asp Asn Tyr Met Tyr Trp Val Arg Gln Ala 
705                 710                 715                 720 


Pro Gly Lys Gly Leu Glu Trp Val Ala Thr Ile Ser Asp Gly Gly Ser 
                725                 730                 735     


Tyr Thr Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
            740                 745                 750         


Asp Asn Ser Lys Asn Thr Leu Phe Leu Gln Met Asp Ser Leu Arg Pro 
        755                 760                 765             


Glu Asp Thr Gly Val Tyr Phe Cys Ala Arg Gly Tyr Tyr Arg Tyr Glu 
    770                 775                 780                 


Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser 
785                 790                 795                 800 


Gly Ser Thr Gly Gly Gly Gly Ser Thr Glu Phe Met Glu Glu Ser Pro 
                805                 810                 815     


Val Ala Ser Gln Ser Lys Ala Glu Lys Asp Tyr Asp Ala Ala Lys Lys 
            820                 825                 830         


Asp Ala Lys Asn Ala Lys Lys Ala Val Glu Asp Ala Gln Lys Ala Leu 
        835                 840                 845             


Asp Asp Ala Lys Ala Ala Gln Lys Lys Tyr Asp Glu Asp Gln Lys Lys 
    850                 855                 860                 


Thr Glu Glu Lys Ala Ala Leu Glu Lys Ala Ala Ser Glu Glu Met Asp 
865                 870                 875                 880 


Lys Ala Val Ala Ala Val Gln Gln Ala Tyr Leu Ala Tyr Gln Gln Ala 
                885                 890                 895     


Thr Asp Lys Ala Ala Lys Asp Ala Ala Asp Lys Met Ile Asp Glu Ala 
            900                 905                 910         


Lys Lys Arg Glu Glu Glu Ala Lys Thr Lys Phe Asn Thr Val Arg Ala 
        915                 920                 925             


Met Val Val Pro Glu Pro Glu Gln Leu Ala Glu Thr Lys Lys Lys Ser 
    930                 935                 940                 


Glu Glu Ala Lys Gln Lys Ala Pro Glu Leu Thr Lys Lys Leu Glu Glu 
945                 950                 955                 960 


Ala Lys Ala Lys Leu Glu Glu Ala Glu Lys Lys Ala Thr Glu Ala Lys 
                965                 970                 975     


Gln Lys Val Asp Ala Glu Glu Val Ala Pro Gln Ala Lys Ile Ala Glu 
            980                 985                 990         


Leu Glu Asn Gln Val His Arg Leu  Glu Gln Glu Leu Lys  Glu Ile Asp 
        995                 1000                 1005             


Glu Ser  Glu Ser Glu Asp Tyr  Ala Lys Glu Gly Phe  Arg Ala Pro 
    1010                 1015                 1020             


Leu Gln  Ser Lys Leu Asp Ala  Lys Lys Ala Lys Leu  Ser Lys Leu 
    1025                 1030                 1035             


Glu Glu  Leu Ser Asp Lys Ile  Asp Glu Leu Asp Ala  Glu Ile Ala 
    1040                 1045                 1050             


Lys Leu  Glu Asp Gln Leu Lys  Ala Ala Glu Glu Asn  Asn Asn Val 
    1055                 1060                 1065             


Glu Asp  Tyr Phe Lys Glu Gly  Leu Glu Lys Thr Ile  Ala Ala Lys 
    1070                 1075                 1080             


Lys Ala  Glu Leu Glu Lys Thr  Glu Ala Asp Leu Lys  Lys Ala Val 
    1085                 1090                 1095             


Asn Glu  Pro Glu Lys Pro Ala  Pro Ala Pro Glu Thr  Pro Ala Pro 
    1100                 1105                 1110             


Glu Leu  Glu His His His His  His His 
    1115                 1120         


<210>  12
<211>  1097
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Bivalent Anti-FcgRI---PspA-HuSA

<400>  12

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Val 
        35                  40                  45              


Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu 
65                  70                  75                  80  


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr 
            100                 105                 110         


Cys His Gln Tyr Leu Ser Ser Trp Thr Phe Gly Gln Gly Thr Lys Val 
        115                 120                 125             


Glu Ile Lys Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
145                 150                 155                 160 


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ser Ser Ser Gly Phe Ile 
                165                 170                 175     


Phe Ser Asp Asn Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly 
            180                 185                 190         


Leu Glu Trp Val Ala Thr Ile Ser Asp Gly Gly Ser Tyr Thr Tyr Tyr 
        195                 200                 205             


Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
    210                 215                 220                 


Asn Thr Leu Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly 
225                 230                 235                 240 


Val Tyr Phe Cys Ala Arg Gly Tyr Tyr Arg Tyr Glu Gly Ala Met Asp 
                245                 250                 255     


Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser Gly Ser Thr Gly 
            260                 265                 270         


Gly Gly Gly Ser Thr Ser Ala Gly Gly Gly Gly Ser Ser Asp Ile Gln 
        275                 280                 285             


Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
    290                 295                 300                 


Thr Ile Thr Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Gln 
305                 310                 315                 320 


Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
                325                 330                 335     


Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Ser Arg 
            340                 345                 350         


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser 
        355                 360                 365             


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys His Gln Tyr Leu Ser 
    370                 375                 380                 


Ser Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ser Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
                405                 410                 415     


Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu 
            420                 425                 430         


Arg Leu Ser Cys Ser Ser Ser Gly Phe Ile Phe Ser Asp Asn Tyr Met 
        435                 440                 445             


Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Thr 
    450                 455                 460                 


Ile Ser Asp Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val Lys Gly 
465                 470                 475                 480 


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe Leu Gln 
                485                 490                 495     


Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys Ala Arg 
            500                 505                 510         


Gly Tyr Tyr Arg Tyr Glu Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr 
        515                 520                 525             


Pro Val Thr Val Ser Ser Gly Ser Thr Gly Gly Gly Gly Ser Thr Ala 
    530                 535                 540                 


Ser Glu Phe Met Glu Glu Ser Pro Val Ala Ser Gln Ser Lys Ala Glu 
545                 550                 555                 560 


Lys Asp Tyr Asp Ala Ala Lys Lys Asp Ala Lys Asn Ala Lys Lys Ala 
                565                 570                 575     


Val Glu Asp Ala Gln Lys Ala Leu Asp Asp Ala Lys Ala Ala Gln Lys 
            580                 585                 590         


Lys Tyr Asp Glu Asp Gln Lys Lys Thr Glu Glu Lys Ala Ala Leu Glu 
        595                 600                 605             


Lys Ala Ala Ser Glu Glu Met Asp Lys Ala Val Ala Ala Val Gln Gln 
    610                 615                 620                 


Ala Tyr Leu Ala Tyr Gln Gln Ala Thr Asp Lys Ala Ala Lys Asp Ala 
625                 630                 635                 640 


Ala Asp Lys Met Ile Asp Glu Ala Lys Lys Arg Glu Glu Glu Ala Lys 
                645                 650                 655     


Thr Lys Phe Asn Thr Val Arg Ala Met Val Val Pro Glu Pro Glu Gln 
            660                 665                 670         


Leu Ala Glu Thr Lys Lys Lys Ser Glu Glu Ala Lys Gln Lys Ala Pro 
        675                 680                 685             


Glu Leu Thr Lys Lys Leu Glu Glu Ala Lys Ala Lys Leu Glu Glu Ala 
    690                 695                 700                 


Glu Lys Lys Ala Thr Glu Ala Lys Gln Lys Val Asp Ala Glu Glu Val 
705                 710                 715                 720 


Ala Pro Gln Ala Lys Ile Ala Glu Leu Glu Asn Gln Val His Arg Leu 
                725                 730                 735     


Glu Gln Glu Leu Lys Glu Ile Asp Glu Ser Glu Ser Glu Asp Tyr Ala 
            740                 745                 750         


Lys Glu Gly Phe Arg Ala Pro Leu Gln Ser Lys Leu Asp Ala Lys Lys 
        755                 760                 765             


Ala Lys Leu Ser Lys Leu Glu Glu Leu Ser Asp Lys Ile Asp Glu Leu 
    770                 775                 780                 


Asp Ala Glu Ile Ala Lys Leu Glu Asp Gln Leu Lys Ala Ala Glu Glu 
785                 790                 795                 800 


Asn Asn Asn Val Glu Asp Tyr Phe Lys Glu Gly Leu Glu Lys Thr Ile 
                805                 810                 815     


Ala Ala Lys Lys Ala Glu Leu Glu Lys Thr Glu Ala Asp Leu Lys Lys 
            820                 825                 830         


Ala Val Asn Glu Pro Glu Lys Pro Ala Pro Ala Pro Glu Thr Pro Ala 
        835                 840                 845             


Pro Glu Leu Glu Gly Gly Ser Gly Gly Cys Thr Leu Glu Lys Cys Cys 
    850                 855                 860                 


Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe 
865                 870                 875                 880 


Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu 
                885                 890                 895     


Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val 
            900                 905                 910         


Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu 
        915                 920                 925             


Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro 
    930                 935                 940                 


Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu 
945                 950                 955                 960 


Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val 
                965                 970                 975     


Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser 
            980                 985                 990         


Ala Leu Glu Val Asp Glu Thr Tyr  Val Pro Lys Glu Phe  Asn Ala Glu 
        995                 1000                 1005             


Thr Phe  Thr Phe His Ala Asp  Ile Cys Thr Leu Ser  Glu Lys Glu 
    1010                 1015                 1020             


Arg Gln  Ile Lys Lys Gln Thr  Ala Leu Val Glu Leu  Val Lys His 
    1025                 1030                 1035             


Lys Pro  Lys Ala Thr Lys Glu  Gln Leu Lys Ala Val  Met Asp Asp 
    1040                 1045                 1050             


Phe Ala  Ala Phe Val Glu Lys  Cys Cys Lys Ala Asp  Asp Lys Glu 
    1055                 1060                 1065             


Thr Cys  Phe Ala Glu Glu Gly  Lys Lys Leu Val Ala  Ala Ser Gln 
    1070                 1075                 1080             


Ala Ala  Leu Gly Leu Arg Thr  His His His His His  His His 
    1085                 1090                 1095         


<210>  13
<211>  1361
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Trivalent Anti-FcgRI---PspA-HuSA

<400>  13

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Val 
        35                  40                  45              


Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu 
65                  70                  75                  80  


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr 
            100                 105                 110         


Cys His Gln Tyr Leu Ser Ser Trp Thr Phe Gly Gln Gly Thr Lys Val 
        115                 120                 125             


Glu Ile Lys Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
145                 150                 155                 160 


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ser Ser Ser Gly Phe Ile 
                165                 170                 175     


Phe Ser Asp Asn Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly 
            180                 185                 190         


Leu Glu Trp Val Ala Thr Ile Ser Asp Gly Gly Ser Tyr Thr Tyr Tyr 
        195                 200                 205             


Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
    210                 215                 220                 


Asn Thr Leu Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly 
225                 230                 235                 240 


Val Tyr Phe Cys Ala Arg Gly Tyr Tyr Arg Tyr Glu Gly Ala Met Asp 
                245                 250                 255     


Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser Gly Ser Thr Gly 
            260                 265                 270         


Gly Gly Gly Ser Thr Ser Ala Gly Gly Gly Gly Ser Ser Asp Ile Gln 
        275                 280                 285             


Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
    290                 295                 300                 


Thr Ile Thr Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Gln 
305                 310                 315                 320 


Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
                325                 330                 335     


Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Ser Arg 
            340                 345                 350         


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser 
        355                 360                 365             


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys His Gln Tyr Leu Ser 
    370                 375                 380                 


Ser Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ser Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
                405                 410                 415     


Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu 
            420                 425                 430         


Arg Leu Ser Cys Ser Ser Ser Gly Phe Ile Phe Ser Asp Asn Tyr Met 
        435                 440                 445             


Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Thr 
    450                 455                 460                 


Ile Ser Asp Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val Lys Gly 
465                 470                 475                 480 


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe Leu Gln 
                485                 490                 495     


Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys Ala Arg 
            500                 505                 510         


Gly Tyr Tyr Arg Tyr Glu Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr 
        515                 520                 525             


Pro Val Thr Val Ser Ser Gly Ser Thr Gly Gly Gly Gly Ser Thr Ala 
    530                 535                 540                 


Ser Gly Gly Gly Gly Ser Ser Asp Ile Gln Leu Thr Gln Ser Pro Ser 
545                 550                 555                 560 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ser 
                565                 570                 575     


Ser Gln Ser Val Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp 
            580                 585                 590         


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Trp Ala 
        595                 600                 605             


Ser Thr Arg Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
    610                 615                 620                 


Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile 
625                 630                 635                 640 


Ala Thr Tyr Tyr Cys His Gln Tyr Leu Ser Ser Trp Thr Phe Gly Gln 
                645                 650                 655     


Gly Thr Lys Val Glu Ile Lys Ser Ser Gly Gly Gly Gly Ser Gly Gly 
            660                 665                 670         


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
        675                 680                 685             


Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ser Ser 
    690                 695                 700                 


Ser Gly Phe Ile Phe Ser Asp Asn Tyr Met Tyr Trp Val Arg Gln Ala 
705                 710                 715                 720 


Pro Gly Lys Gly Leu Glu Trp Val Ala Thr Ile Ser Asp Gly Gly Ser 
                725                 730                 735     


Tyr Thr Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
            740                 745                 750         


Asp Asn Ser Lys Asn Thr Leu Phe Leu Gln Met Asp Ser Leu Arg Pro 
        755                 760                 765             


Glu Asp Thr Gly Val Tyr Phe Cys Ala Arg Gly Tyr Tyr Arg Tyr Glu 
    770                 775                 780                 


Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser 
785                 790                 795                 800 


Gly Ser Thr Gly Gly Gly Gly Ser Thr Glu Phe Met Glu Glu Ser Pro 
                805                 810                 815     


Val Ala Ser Gln Ser Lys Ala Glu Lys Asp Tyr Asp Ala Ala Lys Lys 
            820                 825                 830         


Asp Ala Lys Asn Ala Lys Lys Ala Val Glu Asp Ala Gln Lys Ala Leu 
        835                 840                 845             


Asp Asp Ala Lys Ala Ala Gln Lys Lys Tyr Asp Glu Asp Gln Lys Lys 
    850                 855                 860                 


Thr Glu Glu Lys Ala Ala Leu Glu Lys Ala Ala Ser Glu Glu Met Asp 
865                 870                 875                 880 


Lys Ala Val Ala Ala Val Gln Gln Ala Tyr Leu Ala Tyr Gln Gln Ala 
                885                 890                 895     


Thr Asp Lys Ala Ala Lys Asp Ala Ala Asp Lys Met Ile Asp Glu Ala 
            900                 905                 910         


Lys Lys Arg Glu Glu Glu Ala Lys Thr Lys Phe Asn Thr Val Arg Ala 
        915                 920                 925             


Met Val Val Pro Glu Pro Glu Gln Leu Ala Glu Thr Lys Lys Lys Ser 
    930                 935                 940                 


Glu Glu Ala Lys Gln Lys Ala Pro Glu Leu Thr Lys Lys Leu Glu Glu 
945                 950                 955                 960 


Ala Lys Ala Lys Leu Glu Glu Ala Glu Lys Lys Ala Thr Glu Ala Lys 
                965                 970                 975     


Gln Lys Val Asp Ala Glu Glu Val Ala Pro Gln Ala Lys Ile Ala Glu 
            980                 985                 990         


Leu Glu Asn Gln Val His Arg Leu  Glu Gln Glu Leu Lys  Glu Ile Asp 
        995                 1000                 1005             


Glu Ser  Glu Ser Glu Asp Tyr  Ala Lys Glu Gly Phe  Arg Ala Pro 
    1010                 1015                 1020             


Leu Gln  Ser Lys Leu Asp Ala  Lys Lys Ala Lys Leu  Ser Lys Leu 
    1025                 1030                 1035             


Glu Glu  Leu Ser Asp Lys Ile  Asp Glu Leu Asp Ala  Glu Ile Ala 
    1040                 1045                 1050             


Lys Leu  Glu Asp Gln Leu Lys  Ala Ala Glu Glu Asn  Asn Asn Val 
    1055                 1060                 1065             


Glu Asp  Tyr Phe Lys Glu Gly  Leu Glu Lys Thr Ile  Ala Ala Lys 
    1070                 1075                 1080             


Lys Ala  Glu Leu Glu Lys Thr  Glu Ala Asp Leu Lys  Lys Ala Val 
    1085                 1090                 1095             


Asn Glu  Pro Glu Lys Pro Ala  Pro Ala Pro Glu Thr  Pro Ala Pro 
    1100                 1105                 1110             


Glu Leu  Glu Gly Gly Ser Gly  Gly Cys Thr Leu Glu  Lys Cys Cys 
    1115                 1120                 1125             


Ala Ala  Ala Asp Pro His Glu  Cys Tyr Ala Lys Val  Phe Asp Glu 
    1130                 1135                 1140             


Phe Lys  Pro Leu Val Glu Glu  Pro Gln Asn Leu Ile  Lys Gln Asn 
    1145                 1150                 1155             


Cys Glu  Leu Phe Glu Gln Leu  Gly Glu Tyr Lys Phe  Gln Asn Ala 
    1160                 1165                 1170             


Leu Leu  Val Arg Tyr Thr Lys  Lys Val Pro Gln Val  Ser Thr Pro 
    1175                 1180                 1185             


Thr Leu  Val Glu Val Ser Arg  Asn Leu Gly Lys Val  Gly Ser Lys 
    1190                 1195                 1200             


Cys Cys  Lys His Pro Glu Ala  Lys Arg Met Pro Cys  Ala Glu Asp 
    1205                 1210                 1215             


Tyr Leu  Ser Val Val Leu Asn  Gln Leu Cys Val Leu  His Glu Lys 
    1220                 1225                 1230             


Thr Pro  Val Ser Asp Arg Val  Thr Lys Cys Cys Thr  Glu Ser Leu 
    1235                 1240                 1245             


Val Asn  Arg Arg Pro Cys Phe  Ser Ala Leu Glu Val  Asp Glu Thr 
    1250                 1255                 1260             


Tyr Val  Pro Lys Glu Phe Asn  Ala Glu Thr Phe Thr  Phe His Ala 
    1265                 1270                 1275             


Asp Ile  Cys Thr Leu Ser Glu  Lys Glu Arg Gln Ile  Lys Lys Gln 
    1280                 1285                 1290             


Thr Ala  Leu Val Glu Leu Val  Lys His Lys Pro Lys  Ala Thr Lys 
    1295                 1300                 1305             


Glu Gln  Leu Lys Ala Val Met  Asp Asp Phe Ala Ala  Phe Val Glu 
    1310                 1315                 1320             


Lys Cys  Cys Lys Ala Asp Asp  Lys Glu Thr Cys Phe  Ala Glu Glu 
    1325                 1330                 1335             


Gly Lys  Lys Leu Val Ala Ala  Ser Gln Ala Ala Leu  Gly Leu Arg 
    1340                 1345                 1350             


Thr His  His His His His His  His 
    1355                 1360     


<210>  14
<211>  574
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Non-Fc RI targeted PspA-HuSA

<400>  14

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Gly Gly Gly Ser Thr Ala Ser Glu Phe Met Glu Glu Ser Pro Val Ala 
            20                  25                  30          


Ser Gln Ser Lys Ala Glu Lys Asp Tyr Asp Ala Ala Lys Lys Asp Ala 
        35                  40                  45              


Lys Asn Ala Lys Lys Ala Val Glu Asp Ala Gln Lys Ala Leu Asp Asp 
    50                  55                  60                  


Ala Lys Ala Ala Gln Lys Lys Tyr Asp Glu Asp Gln Lys Lys Thr Glu 
65                  70                  75                  80  


Glu Lys Ala Ala Leu Glu Lys Ala Ala Ser Glu Glu Met Asp Lys Ala 
                85                  90                  95      


Val Ala Ala Val Gln Gln Ala Tyr Leu Ala Tyr Gln Gln Ala Thr Asp 
            100                 105                 110         


Lys Ala Ala Lys Asp Ala Ala Asp Lys Met Ile Asp Glu Ala Lys Lys 
        115                 120                 125             


Arg Glu Glu Glu Ala Lys Thr Lys Phe Asn Thr Val Arg Ala Met Val 
    130                 135                 140                 


Val Pro Glu Pro Glu Gln Leu Ala Glu Thr Lys Lys Lys Ser Glu Glu 
145                 150                 155                 160 


Ala Lys Gln Lys Ala Pro Glu Leu Thr Lys Lys Leu Glu Glu Ala Lys 
                165                 170                 175     


Ala Lys Leu Glu Glu Ala Glu Lys Lys Ala Thr Glu Ala Lys Gln Lys 
            180                 185                 190         


Val Asp Ala Glu Glu Val Ala Pro Gln Ala Lys Ile Ala Glu Leu Glu 
        195                 200                 205             


Asn Gln Val His Arg Leu Glu Gln Glu Leu Lys Glu Ile Asp Glu Ser 
    210                 215                 220                 


Glu Ser Glu Asp Tyr Ala Lys Glu Gly Phe Arg Ala Pro Leu Gln Ser 
225                 230                 235                 240 


Lys Leu Asp Ala Lys Lys Ala Lys Leu Ser Lys Leu Glu Glu Leu Ser 
                245                 250                 255     


Asp Lys Ile Asp Glu Leu Asp Ala Glu Ile Ala Lys Leu Glu Asp Gln 
            260                 265                 270         


Leu Lys Ala Ala Glu Glu Asn Asn Asn Val Glu Asp Tyr Phe Lys Glu 
        275                 280                 285             


Gly Leu Glu Lys Thr Ile Ala Ala Lys Lys Ala Glu Leu Glu Lys Thr 
    290                 295                 300                 


Glu Ala Asp Leu Lys Lys Ala Val Asn Glu Pro Glu Lys Pro Ala Pro 
305                 310                 315                 320 


Ala Pro Glu Thr Pro Ala Pro Glu Leu Glu Gly Gly Ser Gly Gly Cys 
                325                 330                 335     


Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala 
            340                 345                 350         


Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu 
        355                 360                 365             


Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe 
    370                 375                 380                 


Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser 
385                 390                 395                 400 


Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser 
                405                 410                 415     


Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp 
            420                 425                 430         


Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr 
        435                 440                 445             


Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn 
    450                 455                 460                 


Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro 
465                 470                 475                 480 


Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr 
                485                 490                 495     


Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu 
            500                 505                 510         


Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val 
        515                 520                 525             


Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp 
    530                 535                 540                 


Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser 
545                 550                 555                 560 


Gln Ala Ala Leu Gly Leu Arg Thr His His His His His His 
                565                 570                 


<210>  15
<211>  2532
<212>  DNA
<213>  Artificial sequence

<220>
<223>  anti-human FcgRI-PspA

<400>  15
atgggatgga gctgtatcat cctcttcttg gtggccacag ctaccggtgt ccactccgat       60

atccagctga cccagagccc aagcagcctg agcgccagcg tgggtgacag agtgaccatc      120

acctgtaagt ccagtcaaag tgttttatac agttcaaatc agaagaacta cttggcctgg      180

taccagcaga agccaggtaa ggctccaaag ctgctgatct actgggcatc cactagggaa      240

tctggtgtgc caagcagatt cagcggtagc ggtagcggta ccgacttcac cttcaccatc      300

agcagcctcc agccagagga catcgccacc tactactgcc atcaatacct ctcctcgtgg      360

acgttcggcc aagggaccaa ggtggaaatc aagagctctg gcggtggcgg ctccggaggt      420

ggaggcagcg gagggggtgg atccgaggtc caactggtgg agagcggtgg aggtgttgtg      480

caacctggcc ggtccctgcg cctgtcctgc tcctcgtctg gcttcatttt cagtgacaat      540

tacatgtatt gggtgagaca ggcacctgga aaaggtcttg agtgggttgc aaccattagt      600

gatggtggta gttacaccta ctatccagac agtgtgaagg gaagatttac aatatcgaga      660

gacaacagca agaacacatt gttcctgcaa atggacagcc tgagacccga agacaccggg      720

gtctattttt gtgcaagagg ctactatagg tacgaggggg ctatggacta ctggggccaa      780

gggaccccgg tcaccgtctc ctcaggctcg accggtgggg gaggctcgac cggaggcgga      840

ggttctagtg acatccagct gacccagagc ccaagcagcc tgagcgccag cgtgggtgac      900

agagtgacca tcacctgtaa gtccagtcaa agtgttttat acagttcaaa tcagaagaac      960

tacttggcct ggtaccagca gaagccaggt aaggctccaa agctgctgat ctactgggca     1020

tccactaggg aatctggtgt gccaagcaga ttcagcggta gcggtagcgg taccgacttc     1080

accttcacca tcagcagcct ccagccagag gacatcgcca cctactactg ccatcaatac     1140

ctctcctcgt ggacgttcgg ccaagggacc aaggtggaaa tcaagagctc tggcggtggc     1200

ggctccggag gtggaggcag cggagggggt ggatccgagg tccaactggt ggagagcggt     1260

ggaggtgttg tgcaacctgg ccggtccctg cgcctgtcct gctcctcgtc tggcttcatt     1320

ttcagtgaca attacatgta ttgggtgaga caggcacctg gaaaaggtct tgagtgggtt     1380

gcaaccatta gtgatggtgg tagttacacc tactatccag acagtgtgaa gggaagattt     1440

acaatatcga gagacaacag caagaacaca ttgttcctgc aaatggacag cctgagaccc     1500

gaagacaccg gggtctattt ttgtgcaaga ggctactata ggtacgaggg ggctatggac     1560

tactggggcc aagggacccc ggtcaccgtc tcctcaggct cgaccggtgg gggagggtcg     1620

actatggaag aatctcccgt agccagtcag tctaaagctg agaaagacta tgatgcagcg     1680

aagaaagatg ctaagaatgc gaaaaaagca gtagaagatg ctcaaaaggc tttagatgat     1740

gcaaaagctg ctcagaaaaa atatgacgag gatcagaaga aaactgagga gaaagccgcg     1800

ctagaaaaag cagcgtctga agagatggat aaggcagtgg cagcagttca acaagcgtat     1860

ctagcctatc aacaagctac agacaaagcc gcaaaagacg cagcagataa gatgatagat     1920

gaagctaaga aacgcgaaga agaggcaaaa actaaattta atactgttcg agcaatggta     1980

gttcctgagc cagagcagtt ggctgagact aagaaaaaat cagaagaagc taaacaaaaa     2040

gcaccagaac ttactaaaaa actagaagaa gctaaagcaa aattagaaga ggctgagaaa     2100

aaagctactg aagccaaaca aaaagtggat gctgaagaag tcgctcctca agctaaaatc     2160

gctgaattgg aaaatcaagt tcatagacta gaacaagagc tcaaagagat tgatgagtct     2220

gaatcagaag attatgctaa agaaggtttc cgtgctcctc ttcaatctaa attggatgcc     2280

aaaaaagcta aactatcaaa acttgaagag ttaagtgata agattgatga gttagacgct     2340

gaaattgcaa aacttgaaga tcaacttaaa gctgctgaag aaaacaataa tgtagaagac     2400

tactttaaag aaggtttaga gaaaactatt gctgctaaaa aagctgaatt agaaaaaact     2460

gaagctgacc ttaagaaagc agttaatgag ccagaaaaac cagctccagc tccagaaact     2520

ccagccccag aa                                                         2532


<210>  16
<211>  906
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PspA antigen

<400>  16
gaagaatctc ccgtagccag tcagtctaaa gctgagaaag actatgatgc agcgaagaaa       60

gatgctaaga atgcgaaaaa agcagtagaa gatgctcaaa aggctttaga tgatgcaaaa      120

gctgctcaga aaaaatatga cgaggatcag aagaaaactg aggagaaagc cgcgctagaa      180

aaagcagcgt ctgaagagat ggataaggca gtggcagcag ttcaacaagc gtatctagcc      240

tatcaacaag ctacagacaa agccgcaaaa gacgcagcag ataagatgat agatgaagct      300

aagaaacgcg aagaagaggc aaaaactaaa tttaatactg ttcgagcaat ggtagttcct      360

gagccagagc agttggctga gactaagaaa aaatcagaag aagctaaaca aaaagcacca      420

gaacttacta aaaaactaga agaagctaaa gcaaaattag aagaggctga gaaaaaagct      480

actgaagcca aacaaaaagt ggatgctgaa gaagtcgctc ctcaagctaa aatcgctgaa      540

ttggaaaatc aagttcatag actagaacaa gagctcaaag agattgatga gtctgaatca      600

gaagattatg ctaaagaagg tttccgtgct cctcttcaat ctaaattgga tgccaaaaaa      660

gctaaactat caaaacttga agagttaagt gataagattg atgagttaga cgctgaaatt      720

gcaaaacttg aagatcaact taaagctgct gaagaaaaca ataatgtaga agactacttt      780

aaagaaggtt tagagaaaac tattgctgct aaaaaagctg aattagaaaa aactgaagct      840

gaccttaaga aagcagttaa tgagccagaa aaaccagctc cagctccaga aactccagcc      900

ccagaa                                                                 906


<210>  17
<211>  4064
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pUW160s

<400>  17
gggggggggg ggcgctgagg tctgcctcgt gaagaaggtg ttgctgactc ataccaggcc       60

tgaatcgccc catcatccag ccagaaagtg agggagccac ggttgatgag agctttgttg      120

taggtggacc agttggtgat tttgaacttt tgctttgcca cggaacggtc tgcgttgtcg      180

ggaagatgcg tgatctgatc cttcaactca gcaaaagttc gatttattca acaaagccgc      240

cgtcccgtca agtcagcgta atgctctgcc agtgttacaa ccaattaacc aattctgatt      300

agaaaaactc atcgagcatc aaatgaaact gcaatttatt catatcagga ttatcaatac      360

catatttttg aaaaagccgt ttctgtaatg aaggagaaaa ctcaccgagg cagttccata      420

ggatggcaag atcctggtat cggtctgcga ttccgactcg tccaacatca atacaaccta      480

ttaatttccc ctcgtcaaaa ataaggttat caagtgagaa atcaccatga gtgacgactg      540

aatccggtga gaatggcaaa agcttatgca tttctttcca gacttgttca acaggccagc      600

cattacgctc gtcatcaaaa tcactcgcat caaccaaacc gttattcatt cgtgattgcg      660

cctgagcgag acgaaatacg cgatcgctgt taaaaggaca attacaaaca ggaatcgaat      720

gcaaccggcg caggaacact gccagcgcat caacaatatt ttcacctgaa tcaggatatt      780

cttctaatac ctggaatgct gttttcccgg ggatcgcagt ggtgagtaac catgcatcat      840

caggagtacg gataaaatgc ttgatggtcg gaagaggcat aaattccgtc agccagttta      900

gtctgaccat ctcatctgta acatcattgg caacgctacc tttgccatgt ttcagaaaca      960

actctggcgc atcgggcttc ccatacaatc gatagattgt cgcacctgat tgcccgacat     1020

tatcgcgagc ccatttatac ccatataaat cagcatccat gttggaattt aatcgcggcc     1080

tcgagcaaga cgtttcccgt tgaatatggc tcataacacc ccttgtatta ctgtttatgt     1140

aagcagacag gtcgacaata ttggctattg gccattgcat acgttgtatc tatatcataa     1200

tatgtacatt tatattggct catgtccaat atgaccgcca tgttgacatt gattattgac     1260

tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata tggagttccg     1320

cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt     1380

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca     1440

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc     1500

aagtccgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta     1560

catgacctta cgggactttc ctacttggca gtacatctac gtattagtca tcgctattac     1620

catggtgatg cggttttggc agtacaccaa tgggcgtgga tagcggtttg actcacgggg     1680

atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg     1740

ggactttcca aaatgtcgta ataaccccgc cccgttgacg caaatgggcg gtaggcgtgt     1800

acggtgggag gtctatataa gcagagctcg tttagtgaac cgtcagatcg cctggagacg     1860

ccatccacgc tgttttgacc tccatagaag acaccgggac cgatccagcc tccgcggccg     1920

ggaacggtgc attggaacgc ggattccccg tgccaagagt gactcaccgt ccggatctca     1980

gcaagcaggt atgtactctc cagggtgggc ctggcttccc cagtcaagac tccagggatt     2040

tgagggacgc tgtgggctct tctcttacat gtaccttttg cttgcctcaa ccctgactat     2100

cttccaggtc aggatcccag agtcaggggt ctgtattttc ctgctggtgg ctccagttca     2160

ggaacagtaa accctgctcc gaatattgcc tctcacatct cgtcaatctc cgcgaggact     2220

ggggaccctg tgacgaacat ggctagtagg tctttgctaa tcttggtgct ttgcttcctg     2280

cccctggctg ctctgggggc tagcagatct gggccctaac aaaacaaaaa gatggggtta     2340

ttccctaaac ttcatgggtt acgtaattgg aagttggggg acattgccac aagatcatat     2400

tgtacaaaag atcaaacact gttttagaaa acttcctgta aacaggccta ttgattggaa     2460

agtatgtcaa aggattgtgg gtcttttggg ctttgctgct ccatttacac aatgtggata     2520

tcctgcctta atgcctttgt atgcatgtat acaagctaaa caggctttca ctttctcgcc     2580

aacttacaag gcctttctaa gtaaacagta catgaacctt taccccgttg ctcggcaacg     2640

gcctggtctg tgccaagtgt ttgctgacgc aacccccact ggctggggct tggccatagg     2700

ccatcagcgc atgcgtggaa cctttgtggc tcctctgccg atccatactg cggaactcct     2760

agccgcttgt tttgctcgca gccggtctgg agcaaagctc ataggaactg acaattctgt     2820

cgtcctctcg cggaaatata catcgtttcg atctacgtat gatctttttc cctctgccaa     2880

aaattatggg gacatcatga agccccttga gcatctgact tctggctaat aaaggaaatt     2940

tattttcatt gcaatagtgt gttggaattt tttgtgtctc tcactcggaa ggaattctgc     3000

attaatgaat cggccaacgc gcggggagag gcggtttgcg tattgggcgc tcttccgctt     3060

cctcgctcac tgactcgctg cgctcggtcg ttcggctgcg gcgagcggta tcagctcact     3120

caaaggcggt aatacggtta tccacagaat caggggataa cgcaggaaag aacatgtgag     3180

caaaaggcca gcaaaaggcc aggaaccgta aaaaggccgc gttgctggcg tttttccata     3240

ggctccgccc ccctgacgag catcacaaaa atcgacgctc aagtcagagg tggcgaaacc     3300

cgacaggact ataaagatac caggcgtttc cccctggaag ctccctcgtg cgctctcctg     3360

ttccgaccct gccgcttacc ggatacctgt ccgcctttct cccttcggga agcgtggcgc     3420

tttctcatag ctcacgctgt aggtatctca gttcggtgta ggtcgttcgc tccaagctgg     3480

gctgtgtgca cgaacccccc gttcagcccg accgctgcgc cttatccggt aactatcgtc     3540

ttgagtccaa cccggtaaga cacgacttat cgccactggc agcagccact ggtaacagga     3600

ttagcagagc gaggtatgta ggcggtgcta cagagttctt gaagtggtgg cctaactacg     3660

gctacactag aagaacagta tttggtatct gcgctctgct gaagccagtt accttcggaa     3720

aaagagttgg tagctcttga tccggcaaac aaaccaccgc tggtagcggt ggtttttttg     3780

tttgcaagca gcagattacg cgcagaaaaa aaggatctca agaagatcct ttgatctttt     3840

ctacggggtc tgacgctcag tggaacgaaa actcacgtta agggattttg gtcatgagat     3900

tatcaaaaag gatcttcacc tagatccttt taaattaaaa atgaagtttt aaatcaatct     3960

aaagtatata tgagtaaact tggtctgaca gttaccaatg cttaatcagt gaggcaccta     4020

tctcagcgat ctgtctattt cgttcatcca tagttgcctg actc                      4064


<210>  18
<211>  3753
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pJV7563

<400>  18
ggcgtaatgc tctgccagtg ttacaaccaa ttaaccaatt ctgattagaa aaactcatcg       60

agcatcaaat gaaactgcaa tttattcata tcaggattat caataccata tttttgaaaa      120

agccgtttct gtaatgaagg agaaaactca ccgaggcagt tccataggat ggcaagatcc      180

tggtatcggt ctgcgattcc gactcgtcca acatcaatac aacctattaa tttcccctcg      240

tcaaaaataa ggttatcaag tgagaaatca ccatgagtga cgactgaatc cggtgagaat      300

ggcaaaagct tatgcatttc tttccagact tgttcaacag gccagccatt acgctcgtca      360

tcaaaatcac tcgcatcaac caaaccgtta ttcattcgtg attgcgcctg agcgagacga      420

aatacgcgat cgctgttaaa aggacaatta caaacaggaa tcaaatgcaa ccggcgcagg      480

aacactgcca gcgcatcaac aatattttca cctgaatcag gatattcttc taatacctgg      540

aatgctgttt tcccggggat cgcagtggtg agtaaccatg catcatcagg agtacggata      600

aaatgcttga tggtcggaag aggcataaat tccgtcagcc agtttagtct gaccatctca      660

tctgtaacat cattggcaac gctacctttg ccatgtttca gaaacaactc tggcgcatcg      720

ggcttcccat acaatcgata gattgtcgca cctgattgcc cgacattatc gcgagcccat      780

ttatacccat ataaatcagc atccatgttg gaatttaatc gcggcctcga gcaagacgtt      840

tcccgttgaa tatggctcat aacacccctt gtattactgt ttatgtaagc agacaggtcg      900

acaatattgg ctattggcca ttgcatacgt tgtatctata tcataatatg tacatttata      960

ttggctcatg tccaatatga ccgccatgtt gacattgatt attgactagt tattaatagt     1020

aatcaattac ggggtcatta gttcatagcc catatatgga gttccgcgtt acataactta     1080

cggtaaatgg cccgcctggc tgaccgccca acgacccccg cccattgacg tcaataatga     1140

cgtatgttcc catagtaacg ccaataggga ctttccattg acgtcaatgg gtggagtatt     1200

tacggtaaac tgcccacttg gcagtacatc aagtgtatca tatgccaagt ccgcccccta     1260

ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc ccagtacatg accttacggg     1320

actttcctac ttggcagtac atctacgtat tagtcatcgc tattaccatg gtgatgcggt     1380

tttggcagta caccaatggg cgtggatagc ggtttgactc acggggattt ccaagtctcc     1440

accccattga cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat     1500

gtcgtaataa ccccgccccg ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct     1560

atataagcag agctcgttta gtgaaccgtc agatcgcctg gagacgccat ccacgctgtt     1620

ttgacctcca tagaagacac cgggaccgat ccagcctccg cggccgggaa cggtgcattg     1680

gaacgcggat tccccgtgcc aagagtgact caccgtccgg atctcagcaa gcaggtatgt     1740

actctccagg gtgggcctgg cttccccagt caagactcca gggatttgag ggacgctgtg     1800

ggctcttctc ttacatgtac cttttgcttg cctcaaccct gactatcttc caggtcagga     1860

tcccagagtc aggggtctgt attttcctgc tggtggctcc agttcaggaa cagtaaaccc     1920

tgctccgaat attgcctctc acatctcgtc aatctccgcg aggactgggg accctgtgac     1980

gaacatggct agcagatctg ggccctaaca aaacaaaaag atggggttat tccctaaact     2040

tcatgggtta cgtaattgga agttggggga cattgccaca agatcatatt gtacaaaaga     2100

tcaaacactg ttttagaaaa cttcctgtaa acaggcctat tgattggaaa gtatgtcaaa     2160

ggattgtggg tcttttgggc tttgctgctc catttacaca atgtggatat cctgccttaa     2220

tgcctttgta tgcatgtata caagctaaac aggctttcac tttctcgcca acttacaagg     2280

cctttctaag taaacagtac atgaaccttt accccgttgc tcggcaacgg cctggtctgt     2340

gccaagtgtt tgctgacgca acccccactg gctggggctt ggccataggc catcagcgca     2400

tgcgtggaac ctttgtggct cctctgccga tccatactgc ggaactccta gccgcttgtt     2460

ttgctcgcag ccggtctgga gcaaagctca taggaactga caattctgtc gtcctctcgc     2520

ggaaatatac atcgtttcga tctacgtatg atctttttcc ctctgccaaa aattatgggg     2580

acatcatgaa gccccttgag catctgactt ctggctaata aaggaaattt attttcattg     2640

caatagtgtg ttggaatttt ttgtgtctct cactcggaag gaattctgca ttaatgaatc     2700

ggccaacgcg cggggagagg cggtttgcgt attgggcgct cttccgcttc ctcgctcact     2760

gactcgctgc gctcggtcgt tcggctgcgg cgagcggtat cagctcactc aaaggcggta     2820

atacggttat ccacagaatc aggggataac gcaggaaaga acatgtgagc aaaaggccag     2880

caaaaggcca ggaaccgtaa aaaggccgcg ttgctggcgt ttttccatag gctccgcccc     2940

cctgacgagc atcacaaaaa tcgacgctca agtcagaggt ggcgaaaccc gacaggacta     3000

taaagatacc aggcgtttcc ccctggaagc tccctcgtgc gctctcctgt tccgaccctg     3060

ccgcttaccg gatacctgtc cgcctttctc ccttcgggaa gcgtggcgct ttctcatagc     3120

tcacgctgta ggtatctcag ttcggtgtag gtcgttcgct ccaagctggg ctgtgtgcac     3180

gaaccccccg ttcagcccga ccgctgcgcc ttatccggta actatcgtct tgagtccaac     3240

ccggtaagac acgacttatc gccactggca gcagccactg gtaacaggat tagcagagcg     3300

aggtatgtag gcggtgctac agagttcttg aagtggtggc ctaactacgg ctacactaga     3360

agaacagtat ttggtatctg cgctctgctg aagccagtta ccttcggaaa aagagttggt     3420

agctcttgat ccggcaaaca aaccaccgct ggtagcggtg gtttttttgt ttgcaagcag     3480

cagattacgc gcagaaaaaa aggatctcaa gaagatcctt tgatcttttc tacggggtct     3540

gacgctcagt ggaacgaaaa ctcacgttaa gggattttgg tcatgagatt atcaaaaagg     3600

atcttcacct agatcctttt aaattaaaaa tgaagtttta aatcaatcta aagtatatat     3660

gagtaaactt ggtctgacag ttaccaatgc ttaatcagtg aggcacctat ctcagcgatc     3720

tgtctatttc gttcatccat agttgcctga ctc                                  3753


<210>  19
<211>  8912
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Trivalent anti-FcgR1-PspA

<400>  19
acggatcggg agatctcccg atcccctatg gtcgactctc agtacaatct gctctgatgc       60

cgcatagtta agccagtatc tgctccctgc ttgtgtgttg gaggtcgctg agtagtgcgc      120

gagcaaaatt taagctacaa caaggcaagg cttgaccgac aattgcatga agaatctgct      180

tagggttagg cgttttgcgc tgcttcgcga tgtacgggcc agatatacgc gttgacattg      240

attattgact agttattaat agtaatcaat tacggggtca ttagttcata gcccatatat      300

ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc      360

ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag ggactttcca      420

ttgacgtcaa tgggtggact atttacggta aactgcccac ttggcagtac atcaagtgta      480

tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg cctggcatta      540

tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg tattagtcat      600

cgctattacc atggtgatgc ggttttggca gtacatcaat gggcgtggat agcggtttga      660

ctcacgggga tttccaagtc tccaccccat tgacgtcaat gggagtttgt tttggcacca      720

aaatcaacgg gactttccaa aatgtcgtaa caactccgcc ccattgacgc aaatgggcgg      780

taggcgtgta cggtgggagg tctatataag cagagctctc tggctaacta gagaacccac      840

tgcttactgg cttatcgaaa ttaatacgac tcactatagg gagacccaag cttcaccatg      900

ggatggagct gtatcatcct cttcttggtg gccacagcta ccggtgtcca ctccgatatc      960

cagctgaccc agagcccaag cagcctgagc gccagcgtgg gtgacagagt gaccatcacc     1020

tgtaagtcca gtcaaagtgt tttatacagt tcaaatcaga agaactactt ggcctggtac     1080

cagcagaagc caggtaaggc tccaaagctg ctgatctact gggcatccac tagggaatct     1140

ggtgtgccaa gcagattcag cggtagcggt agcggtaccg acttcacctt caccatcagc     1200

agcctccagc cagaggacat cgccacctac tactgccatc aatacctctc ctcgtggacg     1260

ttcggccaag ggaccaaggt ggaaatcaag agctctggcg gtggcggctc cggaggtgga     1320

ggcagcggag ggggtggatc cgaggtccaa ctggtggaga gcggtggagg tgttgtgcaa     1380

cctggccggt ccctgcgcct gtcctgctcc tcgtctggct tcattttcag tgacaattac     1440

atgtattggg tgagacaggc acctggaaaa ggtcttgagt gggttgcaac cattagtgat     1500

ggtggtagtt acacctacta tccagacagt gtgaagggaa gatttacaat atcgagagac     1560

aacagcaaga acacattgtt cctgcaaatg gacagcctga gacccgaaga caccggggtc     1620

tatttttgtg caagaggcta ctataggtac gagggggcta tggactactg gggccaaggg     1680

accccggtca ccgtctcctc aggctcgacc ggtgggggag gctcgaccag cgctggaggc     1740

ggaggttcta gtgacatcca gctgacccag agcccaagca gcctgagcgc cagcgtgggt     1800

gacagagtga ccatcacctg taagtccagt caaagtgttt tatacagttc aaatcagaag     1860

aactacttgg cctggtacca gcagaagcca ggtaaggctc caaagctgct gatctactgg     1920

gcatccacta gggaatctgg tgtgccaagc agattcagcg gtagcggtag cggtaccgac     1980

ttcaccttca ccatcagcag cctccagcca gaggacatcg ccacctacta ctgccatcaa     2040

tacctctcct cgtggacgtt cggccaaggg accaaggtgg aaatcaagag ctctggcggt     2100

ggcggctccg gaggtggagg cagcggaggg ggtggatccg aggtccaact ggtggagagc     2160

ggtggaggtg ttgtgcaacc tggccggtcc ctgcgcctgt cctgctcctc gtctggcttc     2220

attttcagtg acaattacat gtattgggtg agacaggcac ctggaaaagg tcttgagtgg     2280

gttgcaacca ttagtgatgg tggtagttac acctactatc cagacagtgt gaagggaaga     2340

tttacaatat cgagagacaa cagcaagaac acattgttcc tgcaaatgga cagcctgaga     2400

cccgaagaca ccggggtcta tttttgtgca agaggctact ataggtacga gggggctatg     2460

gactactggg gccaagggac cccggtcacc gtctcctcag gctcgaccgg tgggggaggg     2520

tcgactgcta gcggaggcgg aggttctagt gacatccagc tgacccagag cccaagcagc     2580

ctgagcgcca gcgtgggtga cagagtgacc atcacctgta agtccagtca aagtgtttta     2640

tacagttcaa atcagaagaa ctacttggcc tggtaccagc agaagccagg taaggctcca     2700

aagctgctga tctactgggc atccactagg gaatctggtg tgccaagcag attcagcggt     2760

agcggtagcg gtaccgactt caccttcacc atcagcagcc tccagccaga ggacatcgcc     2820

acctactact gccatcaata cctctcctcg tggacgttcg gccaagggac caaggtggaa     2880

atcaagagct ctggcggtgg cggctccgga ggtggaggca gcggaggggg tggatccgag     2940

gtccaactgg tggagagcgg tggaggtgtt gtgcaacctg gccggtccct gcgcctgtcc     3000

tgctcctcgt ctggcttcat tttcagtgac aattacatgt attgggtgag acaggcacct     3060

ggaaaaggtc ttgagtgggt tgcaaccatt agtgatggtg gtagttacac ctactatcca     3120

gacagtgtga agggaagatt tacaatatcg agagacaaca gcaagaacac attgttcctg     3180

caaatggaca gcctgagacc cgaagacacc ggggtctatt tttgtgcaag aggctactat     3240

aggtacgagg gggctatgga ctactggggc caagggaccc cggtcaccgt ctcctcaggc     3300

tcgaccggtg ggggagggtc gactgaattc atggaagaat ctcccgtagc cagtcagtct     3360

aaagctgaga aagactatga tgcagcgaag aaagatgcta agaatgcgaa aaaagcagta     3420

gaagatgctc aaaaggcttt agatgatgca aaagctgctc agaaaaaata tgacgaggat     3480

cagaagaaaa ctgaggagaa agccgcgcta gaaaaagcag cgtctgaaga gatggataag     3540

gcagtggcag cagttcaaca agcgtatcta gcctatcaac aagctacaga caaagccgca     3600

aaagacgcag cagataagat gatagatgaa gctaagaaac gcgaagaaga ggcaaaaact     3660

aaatttaata ctgttcgagc aatggtagtt cctgagccag agcagttggc tgagactaag     3720

aaaaaatcag aagaagctaa acaaaaagca ccagaactta ctaaaaaact agaagaagct     3780

aaagcaaaat tagaagaggc tgagaaaaaa gctactgaag ccaaacaaaa agtggatgct     3840

gaagaagtcg ctcctcaagc taaaatcgct gaattggaaa atcaagttca tagactagaa     3900

caagagctca aagagattga tgagtctgaa tcagaagatt atgctaaaga aggtttccgt     3960

gctcctcttc aatctaaatt ggatgccaaa aaagctaaac tatcaaaact tgaagagtta     4020

agtgataaga ttgatgagtt agacgctgaa attgcaaaac ttgaagatca acttaaagct     4080

gctgaagaaa acaataatgt agaagactac tttaaagaag gtttagagaa aactattgct     4140

gctaaaaaag ctgaattaga aaaaactgaa gctgacctta agaaagcagt taatgagcca     4200

gaaaaaccag ctccagctcc agaaactcca gccccagaac tcgagcacca ccaccaccac     4260

cactgagatc cggctgctaa caaagcccga aaggaagctg agttggctgc tgccaccgct     4320

gagcaataac tagcataacc ccttggggcc tctaaacggg tcttgagggg ttttgcggcc     4380

gcacgacaga aactcatctc agaagaggat ctgaatggcg ccgcacatca ccatcatcac     4440

cattgattct agagggccct attctatagt gtcacctaaa tgctagagct cgctgatcag     4500

cctcgactgt gccttctagt tgccagccat ctgttgtttg cccctccccc gtgccttcct     4560

tgaccctgga aggtgccact cccactgtcc tttcctaata aaatgaggaa attgcatcgc     4620

attgtctgag taggtgtcat tctattctgg ggggtggggt ggggcaggac agcaaggggg     4680

aggattggga agacaatagc aggcatgctg gggatgcggt gggctctatg gcttctgagg     4740

cggaaagaac cagctggggc tctagggggt atccccacgc gccctgtagc ggcgcattaa     4800

gcgcggcggg tgtggtggtt acgcgcagcg tgaccgctac acttgccagc gccctagcgc     4860

ccgctccttt cgctttcttc ccttcctttc tcgccacgtt cgccggcttt ccccgtcaag     4920

ctctaaatcg gggcatccct ttagggttcc gatttagtgc tttacggcac ctcgacccca     4980

aaaaacttga ttagggtgat ggttcacgta gtgggccatc gccctgatag acggtttttc     5040

gccctttgac gttggagtcc acgttcttta atagtggact cttgttccaa actggaacaa     5100

cactcaaccc tatctcggtc tattcttttg atttataagg gattttgggg atttcggcct     5160

attggttaaa aaatgagctg atttaacaaa aatttaacgc gaattaattc tgtggaatgt     5220

gtgtcagtta gggtgtggaa agtccccagg ctccccaggc aggcagaagt atgcaaagca     5280

tgcatctcaa ttagtcagca accaggtgtg gaaagtcccc aggctcccca gcaggcagaa     5340

gtatgcaaag catgcatctc aattagtcag caaccatagt cccgccccta actccgccca     5400

tcccgcccct aactccgccc agttccgccc attctccgcc ccatggctga ctaatttttt     5460

ttatttatgc agaggccgag gccgcctctg cctctgagct attccagaag tagtgaggag     5520

gcttttttgg aggcctaggc ttttgcaaaa agctcccggg agcttgtata tccattttcg     5580

gatctgatca agagacagga tgaggatcgt ttcgcatgat tgaacaagat ggattgcacg     5640

caggttctcc ggccgcttgg gtggagaggc tattcggcta tgactgggca caacagacaa     5700

tcggctgctc tgatgccgcc gtgttccggc tgtcagcgca ggggcgcccg gttctttttg     5760

tcaagaccga cctgtccggt gccctgaatg aactgcagga cgaggcagcg cggctatcgt     5820

ggctggccac gacgggcgtt ccttgcgcag ctgtgctcga cgttgtcact gaagcgggaa     5880

gggactggct gctattgggc gaagtgccgg ggcaggatct cctgtcatct caccttgctc     5940

ctgccgagaa agtatccatc atggctgatg caatgcggcg gctgcatacg cttgatccgg     6000

ctacctgccc attcgaccac caagcgaaac atcgcatcga gcgagcacgt actcggatgg     6060

aagccggtct tgtcgatcag gatgatctgg acgaagagca tcaggggctc gcgccagccg     6120

aactgttcgc caggctcaag gcgcgcatgc ccgacggcga ggatctcgtc gtgacccatg     6180

gcgatgcctg cttgccgaat atcatggtgg aaaatggccg cttttctgga ttcatcgact     6240

gtggccggct gggtgtggcg gaccgctatc aggacatagc gttggctacc cgtgatattg     6300

ctgaagagct tggcggcgaa tgggctgacc gcttcctcgt gctttacggt atcgccgctc     6360

ccgattcgca gcgcatcgcc ttctatcgcc ttcttgacga gttcttctga gcgggactct     6420

ggggttcgaa atgaccgacc aagcgacgcc caacctgcca tcacgagatt tcgattccac     6480

cgccgccttc tatgaaaggt tgggcttcgg aatcgttttc cgggacgccg gctggatgat     6540

cctccagcgc ggggatctca tgctggagtt cttcgcccac cccaacttgt ttattgcagc     6600

ttataatggt tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc     6660

actgcattct agttgtggtt tgtccaaact catcaatgta tcttatcatg tctgtatacc     6720

gtcgacctct agctagagct tggcgtaatc atggtcatag ctgtttcctg tgtgaaattg     6780

ttatccgctc acaattccac acaacatacg agccggaagc ataaagtgta aagcctgggg     6840

tgcctaatga gtgagctaac tcacattaat tgcgttgcgc tcactgcccg ctttccagtc     6900

gggaaacctg tcgtgccagc tgcattaatg aatcggccaa cgcgcgggga gaggcggttt     6960

gcgtattggg cgctcttccg cttcctcgct cactgactcg ctgcgctcgg tcgttcggct     7020

gcggcgagcg gtatcagctc actcaaaggc ggtaatacgg ttatccacag aatcagggga     7080

taacgcagga aagaacatgt gagcaaaagg ccagcaaaag gccaggaacc gtaaaaaggc     7140

cgcgttgctg gcgtttttcc ataggctccg cccccctgac gagcatcaca aaaatcgacg     7200

ctcaagtcag aggtggcgaa acccgacagg actataaaga taccaggcgt ttccccctgg     7260

aagctccctc gtgcgctctc ctgttccgac cctgccgctt accggatacc tgtccgcctt     7320

tctcccttcg ggaagcgtgg cgctttctca atgctcacgc tgtaggtatc tcagttcggt     7380

gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc ccgaccgctg     7440

cgccttatcc ggtaactatc gtcttgagtc caacccggta agacacgact tatcgccact     7500

ggcagcagcc actggtaaca ggattagcag agcgaggtat gtaggcggtg ctacagagtt     7560

cttgaagtgg tggcctaact acggctacac tagaaggaca gtatttggta tctgcgctct     7620

gctgaagcca gttaccttcg gaaaaagagt tggtagctct tgatccggca aacaaaccac     7680

cgctggtagc ggtggttttt ttgtttgcaa gcagcagatt acgcgcagaa aaaaaggatc     7740

tcaagaagat cctttgatct tttctacggg gtctgacgct cagtggaacg aaaactcacg     7800

ttaagggatt ttggtcatga gattatcaaa aaggatcttc acctagatcc ttttaaatta     7860

aaaatgaagt tttaaatcaa tctaaagtat atatgagtaa acttggtctg acagttacca     7920

atgcttaatc agtgaggcac ctatctcagc gatctgtcta tttcgttcat ccatagttgc     7980

ctgactcccc gtcgtgtaga taactacgat acgggagggc ttaccatctg gccccagtgc     8040

tgcaatgata ccgcgagacc cacgctcacc ggctccagat ttatcagcaa taaaccagcc     8100

agccggaagg gccgagcgca gaagtggtcc tgcaacttta tccgcctcca tccagtctat     8160

taattgttgc cgggaagcta gagtaagtag ttcgccagtt aatagtttgc gcaacgttgt     8220

tgccattgct acaggcatcg tggtgtcacg ctcgtcgttt ggtatggctt cattcagctc     8280

cggttcccaa cgatcaaggc gagttacatg atcccccatg ttgtgcaaaa aagcggttag     8340

ctccttcggt cctccgatcg ttgtcagaag taagttggcc gcagtgttat cactcatggt     8400

tatggcagca ctgcataatt ctcttactgt catgccatcc gtaagatgct tttctgtgac     8460

tggtgagtac tcaaccaagt cattctgaga atagtgtatg cggcgaccga gttgctcttg     8520

cccggcgtca atacgggata ataccgcgcc acatagcaga actttaaaag tgctcatcat     8580

tggaaaacgt tcttcggggc gaaaactctc aaggatctta ccgctgttga gatccagttc     8640

gatgtaaccc actcgtgcac ccaactgatc ttcagcatct tttactttca ccagcgtttc     8700

tgggtgagca aaaacaggaa ggcaaaatgc cgcaaaaaag ggaataaggg cgacacggaa     8760

atgttgaata ctcatactct tcctttttca atattattga agcatttatc agggttattg     8820

tctcatgagc ggatacatat ttgaatgtat ttagaaaaat aaacaaatag gggttccgcg     8880

cacatttccc cgaaaagtgc cacctgacgt cg                                   8912


<210>  20
<211>  9626
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Trivalent anti-FcgR1-PspA-HuSA

<400>  20
acggatcggg agatctcccg atcccctatg gtcgactctc agtacaatct gctctgatgc       60

cgcatagtta agccagtatc tgctccctgc ttgtgtgttg gaggtcgctg agtagtgcgc      120

gagcaaaatt taagctacaa caaggcaagg cttgaccgac aattgcatga agaatctgct      180

tagggttagg cgttttgcgc tgcttcgcga tgtacgggcc agatatacgc gttgacattg      240

attattgact agttattaat agtaatcaat tacggggtca ttagttcata gcccatatat      300

ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc      360

ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag ggactttcca      420

ttgacgtcaa tgggtggact atttacggta aactgcccac ttggcagtac atcaagtgta      480

tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg cctggcatta      540

tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg tattagtcat      600

cgctattacc atggtgatgc ggttttggca gtacatcaat gggcgtggat agcggtttga      660

ctcacgggga tttccaagtc tccaccccat tgacgtcaat gggagtttgt tttggcacca      720

aaatcaacgg gactttccaa aatgtcgtaa caactccgcc ccattgacgc aaatgggcgg      780

taggcgtgta cggtgggagg tctatataag cagagctctc tggctaacta gagaacccac      840

tgcttactgg cttatcgaaa ttaatacgac tcactatagg gagacccaag cttcaccatg      900

ggatggagct gtatcatcct cttcttggtg gccacagcta ccggtgtcca ctccgatatc      960

cagctgaccc agagcccaag cagcctgagc gccagcgtgg gtgacagagt gaccatcacc     1020

tgtaagtcca gtcaaagtgt tttatacagt tcaaatcaga agaactactt ggcctggtac     1080

cagcagaagc caggtaaggc tccaaagctg ctgatctact gggcatccac tagggaatct     1140

ggtgtgccaa gcagattcag cggtagcggt agcggtaccg acttcacctt caccatcagc     1200

agcctccagc cagaggacat cgccacctac tactgccatc aatacctctc ctcgtggacg     1260

ttcggccaag ggaccaaggt ggaaatcaag agctctggcg gtggcggctc cggaggtgga     1320

ggcagcggag ggggtggatc cgaggtccaa ctggtggaga gcggtggagg tgttgtgcaa     1380

cctggccggt ccctgcgcct gtcctgctcc tcgtctggct tcattttcag tgacaattac     1440

atgtattggg tgagacaggc acctggaaaa ggtcttgagt gggttgcaac cattagtgat     1500

ggtggtagtt acacctacta tccagacagt gtgaagggaa gatttacaat atcgagagac     1560

aacagcaaga acacattgtt cctgcaaatg gacagcctga gacccgaaga caccggggtc     1620

tatttttgtg caagaggcta ctataggtac gagggggcta tggactactg gggccaaggg     1680

accccggtca ccgtctcctc aggctcgacc ggtgggggag gctcgaccag cgctggaggc     1740

ggaggttcta gtgacatcca gctgacccag agcccaagca gcctgagcgc cagcgtgggt     1800

gacagagtga ccatcacctg taagtccagt caaagtgttt tatacagttc aaatcagaag     1860

aactacttgg cctggtacca gcagaagcca ggtaaggctc caaagctgct gatctactgg     1920

gcatccacta gggaatctgg tgtgccaagc agattcagcg gtagcggtag cggtaccgac     1980

ttcaccttca ccatcagcag cctccagcca gaggacatcg ccacctacta ctgccatcaa     2040

tacctctcct cgtggacgtt cggccaaggg accaaggtgg aaatcaagag ctctggcggt     2100

ggcggctccg gaggtggagg cagcggaggg ggtggatccg aggtccaact ggtggagagc     2160

ggtggaggtg ttgtgcaacc tggccggtcc ctgcgcctgt cctgctcctc gtctggcttc     2220

attttcagtg acaattacat gtattgggtg agacaggcac ctggaaaagg tcttgagtgg     2280

gttgcaacca ttagtgatgg tggtagttac acctactatc cagacagtgt gaagggaaga     2340

tttacaatat cgagagacaa cagcaagaac acattgttcc tgcaaatgga cagcctgaga     2400

cccgaagaca ccggggtcta tttttgtgca agaggctact ataggtacga gggggctatg     2460

gactactggg gccaagggac cccggtcacc gtctcctcag gctcgaccgg tgggggaggc     2520

tcgactgcta gcggaggcgg aggttctagt gacatccagc tgacccagag cccaagcagc     2580

ctgagcgcca gcgtgggtga cagagtgacc atcacctgta agtccagtca aagtgtttta     2640

tacagttcaa atcagaagaa ctacttggcc tggtaccagc agaagccagg taaggctcca     2700

aagctgctga tctactgggc atccactagg gaatctggtg tgccaagcag attcagcggt     2760

agcggtagcg gtaccgactt caccttcacc atcagcagcc tccagccaga ggacatcgcc     2820

acctactact gccatcaata cctctcctcg tggacgttcg gccaagggac caaggtggaa     2880

atcaagagct ctggcggtgg cggctccgga ggtggaggca gcggaggggg tggatccgag     2940

gtccaactgg tggagagcgg tggaggtgtt gtgcaacctg gccggtccct gcgcctgtcc     3000

tgctcctcgt ctggcttcat tttcagtgac aattacatgt attgggtgag acaggcacct     3060

ggaaaaggtc ttgagtgggt tgcaaccatt agtgatggtg gtagttacac ctactatcca     3120

gacagtgtga agggaagatt tacaatatcg agagacaaca gcaagaacac attgttcctg     3180

caaatggaca gcctgagacc cgaagacacc ggggtctatt tttgtgcaag aggctactat     3240

aggtacgagg gggctatgga ctactggggc caagggaccc cggtcaccgt ctcctcaggc     3300

tcgaccggtg ggggaggctc gactgaattc atggaagaat ctcccgtagc cagtcagtct     3360

aaagctgaga aagactatga tgcagcgaag aaagatgcta agaatgcgaa aaaagcagta     3420

gaagatgctc aaaaggcttt agatgatgca aaagctgctc agaaaaaata tgacgaggat     3480

cagaagaaaa ctgaggagaa agccgcgcta gaaaaagcag cgtctgaaga gatggataag     3540

gcagtggcag cagttcaaca agcgtatcta gcctatcaac aagctacaga caaagccgca     3600

aaagacgcag cagataagat gatagatgaa gctaagaaac gcgaagaaga ggcaaaaact     3660

aaatttaata ctgttcgagc aatggtagtt cctgagccag agcagttggc tgagactaag     3720

aaaaaatcag aagaagctaa acaaaaagca ccagaactta ctaaaaaact agaagaagct     3780

aaagcaaaat tagaagaggc tgagaaaaaa gctactgaag ccaaacaaaa agtggatgct     3840

gaagaagtcg ctcctcaagc taaaatcgct gaattggaaa atcaagttca tagactagaa     3900

caagagctca aagagattga tgagtctgaa tcagaagatt atgctaaaga aggtttccgt     3960

gctcctcttc aatctaaatt ggatgccaaa aaagctaaac tatcaaaact tgaagagtta     4020

agtgataaga ttgatgagtt agacgctgaa attgcaaaac ttgaagatca acttaaagct     4080

gctgaagaaa acaataatgt agaagactac tttaaagaag gtttagagaa aactattgct     4140

gctaaaaaag ctgaattaga aaaaactgaa gctgacctta agaaagcagt taatgagcca     4200

gaaaaaccag ctccagctcc agaaactcca gccccagaac tcgagggtgg atcaggcggt     4260

tgtacactag agaagtgctg tgccgctgca gatcctcatg aatgctatgc caaagtgttc     4320

gatgaattta aacctcttgt ggaagagcct cagaatttaa tcaaacaaaa ttgtgagctt     4380

tttgagcagc ttggagagta caaattccag aatgcgctat tagttcgtta caccaagaaa     4440

gtaccccaag tgtcaactcc aactcttgta gaggtctcaa gaaacctagg aaaagtgggc     4500

agcaaatgtt gtaaacatcc tgaagcaaaa agaatgccct gtgcagaaga ctatctatcc     4560

gtggtcctga accagttatg tgtgttgcat gagaaaacgc cagtaagtga cagagtcacc     4620

aaatgctgca cagaatcctt ggtgaacagg cgaccatgct tttcagctct ggaagtcgat     4680

gaaacatacg ttcccaaaga gtttaatgct gaaacattca ccttccatgc agatatatgc     4740

acactttctg agaaggagag acaaatcaag aaacaaactg cacttgttga gctcgtgaaa     4800

cacaagccca aggcaacaaa agagcaactg aaagctgtta tggatgattt cgcagctttt     4860

gtagagaagt gctgcaaggc tgacgataag gagacctgct ttgccgagga gggtaaaaaa     4920

cttgttgctg caagtcaagc tgccttaggc ttacgtacgc accaccacca ccaccactga     4980

gatccggctg ctaacaaagc ccgaaaggaa gctgagttgg ctgctgccac cgctgagcaa     5040

taactagcat aaccccttgg ggcctctaaa cgggtcttga ggggttttgc ggccgcacga     5100

cagaaactca tctcagaaga ggatctgaat ggcgccgcac atcaccatca tcaccattga     5160

ttctagaggg ccctattcta tagtgtcacc taaatgctag agctcgctga tcagcctcga     5220

ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc     5280

tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc     5340

tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt     5400

gggaagacaa tagcaggcat gctggggatg cggtgggctc tatggcttct gaggcggaaa     5460

gaaccagctg gggctctagg gggtatcccc acgcgccctg tagcggcgca ttaagcgcgg     5520

cgggtgtggt ggttacgcgc agcgtgaccg ctacacttgc cagcgcccta gcgcccgctc     5580

ctttcgcttt cttcccttcc tttctcgcca cgttcgccgg ctttccccgt caagctctaa     5640

atcggggcat ccctttaggg ttccgattta gtgctttacg gcacctcgac cccaaaaaac     5700

ttgattaggg tgatggttca cgtagtgggc catcgccctg atagacggtt tttcgccctt     5760

tgacgttgga gtccacgttc tttaatagtg gactcttgtt ccaaactgga acaacactca     5820

accctatctc ggtctattct tttgatttat aagggatttt ggggatttcg gcctattggt     5880

taaaaaatga gctgatttaa caaaaattta acgcgaatta attctgtgga atgtgtgtca     5940

gttagggtgt ggaaagtccc caggctcccc aggcaggcag aagtatgcaa agcatgcatc     6000

tcaattagtc agcaaccagg tgtggaaagt ccccaggctc cccagcaggc agaagtatgc     6060

aaagcatgca tctcaattag tcagcaacca tagtcccgcc cctaactccg cccatcccgc     6120

ccctaactcc gcccagttcc gcccattctc cgccccatgg ctgactaatt ttttttattt     6180

atgcagaggc cgaggccgcc tctgcctctg agctattcca gaagtagtga ggaggctttt     6240

ttggaggcct aggcttttgc aaaaagctcc cgggagcttg tatatccatt ttcggatctg     6300

atcaagagac aggatgagga tcgtttcgca tgattgaaca agatggattg cacgcaggtt     6360

ctccggccgc ttgggtggag aggctattcg gctatgactg ggcacaacag acaatcggct     6420

gctctgatgc cgccgtgttc cggctgtcag cgcaggggcg cccggttctt tttgtcaaga     6480

ccgacctgtc cggtgccctg aatgaactgc aggacgaggc agcgcggcta tcgtggctgg     6540

ccacgacggg cgttccttgc gcagctgtgc tcgacgttgt cactgaagcg ggaagggact     6600

ggctgctatt gggcgaagtg ccggggcagg atctcctgtc atctcacctt gctcctgccg     6660

agaaagtatc catcatggct gatgcaatgc ggcggctgca tacgcttgat ccggctacct     6720

gcccattcga ccaccaagcg aaacatcgca tcgagcgagc acgtactcgg atggaagccg     6780

gtcttgtcga tcaggatgat ctggacgaag agcatcaggg gctcgcgcca gccgaactgt     6840

tcgccaggct caaggcgcgc atgcccgacg gcgaggatct cgtcgtgacc catggcgatg     6900

cctgcttgcc gaatatcatg gtggaaaatg gccgcttttc tggattcatc gactgtggcc     6960

ggctgggtgt ggcggaccgc tatcaggaca tagcgttggc tacccgtgat attgctgaag     7020

agcttggcgg cgaatgggct gaccgcttcc tcgtgcttta cggtatcgcc gctcccgatt     7080

cgcagcgcat cgccttctat cgccttcttg acgagttctt ctgagcggga ctctggggtt     7140

cgaaatgacc gaccaagcga cgcccaacct gccatcacga gatttcgatt ccaccgccgc     7200

cttctatgaa aggttgggct tcggaatcgt tttccgggac gccggctgga tgatcctcca     7260

gcgcggggat ctcatgctgg agttcttcgc ccaccccaac ttgtttattg cagcttataa     7320

tggttacaaa taaagcaata gcatcacaaa tttcacaaat aaagcatttt tttcactgca     7380

ttctagttgt ggtttgtcca aactcatcaa tgtatcttat catgtctgta taccgtcgac     7440

ctctagctag agcttggcgt aatcatggtc atagctgttt cctgtgtgaa attgttatcc     7500

gctcacaatt ccacacaaca tacgagccgg aagcataaag tgtaaagcct ggggtgccta     7560

atgagtgagc taactcacat taattgcgtt gcgctcactg cccgctttcc agtcgggaaa     7620

cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat     7680

tgggcgctct tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg     7740

agcggtatca gctcactcaa aggcggtaat acggttatcc acagaatcag gggataacgc     7800

aggaaagaac atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt     7860

gctggcgttt ttccataggc tccgcccccc tgacgagcat cacaaaaatc gacgctcaag     7920

tcagaggtgg cgaaacccga caggactata aagataccag gcgtttcccc ctggaagctc     7980

cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga tacctgtccg cctttctccc     8040

ttcgggaagc gtggcgcttt ctcaatgctc acgctgtagg tatctcagtt cggtgtaggt     8100

cgttcgctcc aagctgggct gtgtgcacga accccccgtt cagcccgacc gctgcgcctt     8160

atccggtaac tatcgtcttg agtccaaccc ggtaagacac gacttatcgc cactggcagc     8220

agccactggt aacaggatta gcagagcgag gtatgtaggc ggtgctacag agttcttgaa     8280

gtggtggcct aactacggct acactagaag gacagtattt ggtatctgcg ctctgctgaa     8340

gccagttacc ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg     8400

tagcggtggt ttttttgttt gcaagcagca gattacgcgc agaaaaaaag gatctcaaga     8460

agatcctttg atcttttcta cggggtctga cgctcagtgg aacgaaaact cacgttaagg     8520

gattttggtc atgagattat caaaaaggat cttcacctag atccttttaa attaaaaatg     8580

aagttttaaa tcaatctaaa gtatatatga gtaaacttgg tctgacagtt accaatgctt     8640

aatcagtgag gcacctatct cagcgatctg tctatttcgt tcatccatag ttgcctgact     8700

ccccgtcgtg tagataacta cgatacggga gggcttacca tctggcccca gtgctgcaat     8760

gataccgcga gacccacgct caccggctcc agatttatca gcaataaacc agccagccgg     8820

aagggccgag cgcagaagtg gtcctgcaac tttatccgcc tccatccagt ctattaattg     8880

ttgccgggaa gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat     8940

tgctacaggc atcgtggtgt cacgctcgtc gtttggtatg gcttcattca gctccggttc     9000

ccaacgatca aggcgagtta catgatcccc catgttgtgc aaaaaagcgg ttagctcctt     9060

cggtcctccg atcgttgtca gaagtaagtt ggccgcagtg ttatcactca tggttatggc     9120

agcactgcat aattctctta ctgtcatgcc atccgtaaga tgcttttctg tgactggtga     9180

gtactcaacc aagtcattct gagaatagtg tatgcggcga ccgagttgct cttgcccggc     9240

gtcaatacgg gataataccg cgccacatag cagaacttta aaagtgctca tcattggaaa     9300

acgttcttcg gggcgaaaac tctcaaggat cttaccgctg ttgagatcca gttcgatgta     9360

acccactcgt gcacccaact gatcttcagc atcttttact ttcaccagcg tttctgggtg     9420

agcaaaaaca ggaaggcaaa atgccgcaaa aaagggaata agggcgacac ggaaatgttg     9480

aatactcata ctcttccttt ttcaatatta ttgaagcatt tatcagggtt attgtctcat     9540

gagcggatac atatttgaat gtatttagaa aaataaacaa ataggggttc cgcgcacatt     9600

tccccgaaaa gtgccacctg acgtcg                                          9626


<210>  21
<211>  8102
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Bivalent anti-FcgR1-PspA

<400>  21
acggatcggg agatctcccg atcccctatg gtcgactctc agtacaatct gctctgatgc       60

cgcatagtta agccagtatc tgctccctgc ttgtgtgttg gaggtcgctg agtagtgcgc      120

gagcaaaatt taagctacaa caaggcaagg cttgaccgac aattgcatga agaatctgct      180

tagggttagg cgttttgcgc tgcttcgcga tgtacgggcc agatatacgc gttgacattg      240

attattgact agttattaat agtaatcaat tacggggtca ttagttcata gcccatatat      300

ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc      360

ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag ggactttcca      420

ttgacgtcaa tgggtggact atttacggta aactgcccac ttggcagtac atcaagtgta      480

tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg cctggcatta      540

tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg tattagtcat      600

cgctattacc atggtgatgc ggttttggca gtacatcaat gggcgtggat agcggtttga      660

ctcacgggga tttccaagtc tccaccccat tgacgtcaat gggagtttgt tttggcacca      720

aaatcaacgg gactttccaa aatgtcgtaa caactccgcc ccattgacgc aaatgggcgg      780

taggcgtgta cggtgggagg tctatataag cagagctctc tggctaacta gagaacccac      840

tgcttactgg cttatcgaaa ttaatacgac tcactatagg gagacccaag cttcaccatg      900

ggatggagct gtatcatcct cttcttggtg gccacagcta ccggtgtcca ctccgatatc      960

cagctgaccc agagcccaag cagcctgagc gccagcgtgg gtgacagagt gaccatcacc     1020

tgtaagtcca gtcaaagtgt tttatacagt tcaaatcaga agaactactt ggcctggtac     1080

cagcagaagc caggtaaggc tccaaagctg ctgatctact gggcatccac tagggaatct     1140

ggtgtgccaa gcagattcag cggtagcggt agcggtaccg acttcacctt caccatcagc     1200

agcctccagc cagaggacat cgccacctac tactgccatc aatacctctc ctcgtggacg     1260

ttcggccaag ggaccaaggt ggaaatcaag agctctggcg gtggcggctc cggaggtgga     1320

ggcagcggag ggggtggatc cgaggtccaa ctggtggaga gcggtggagg tgttgtgcaa     1380

cctggccggt ccctgcgcct gtcctgctcc tcgtctggct tcattttcag tgacaattac     1440

atgtattggg tgagacaggc acctggaaaa ggtcttgagt gggttgcaac cattagtgat     1500

ggtggtagtt acacctacta tccagacagt gtgaagggaa gatttacaat atcgagagac     1560

aacagcaaga acacattgtt cctgcaaatg gacagcctga gacccgaaga caccggggtc     1620

tatttttgtg caagaggcta ctataggtac gagggggcta tggactactg gggccaaggg     1680

accccggtca ccgtctcctc aggctcgacc ggtgggggag gctcgaccgg aggcggaggt     1740

tctagtgaca tccagctgac ccagagccca agcagcctga gcgccagcgt gggtgacaga     1800

gtgaccatca cctgtaagtc cagtcaaagt gttttataca gttcaaatca gaagaactac     1860

ttggcctggt accagcagaa gccaggtaag gctccaaagc tgctgatcta ctgggcatcc     1920

actagggaat ctggtgtgcc aagcagattc agcggtagcg gtagcggtac cgacttcacc     1980

ttcaccatca gcagcctcca gccagaggac atcgccacct actactgcca tcaatacctc     2040

tcctcgtgga cgttcggcca agggaccaag gtggaaatca agagctctgg cggtggcggc     2100

tccggaggtg gaggcagcgg agggggtgga tccgaggtcc aactggtgga gagcggtgga     2160

ggtgttgtgc aacctggccg gtccctgcgc ctgtcctgct cctcgtctgg cttcattttc     2220

agtgacaatt acatgtattg ggtgagacag gcacctggaa aaggtcttga gtgggttgca     2280

accattagtg atggtggtag ttacacctac tatccagaca gtgtgaaggg aagatttaca     2340

atatcgagag acaacagcaa gaacacattg ttcctgcaaa tggacagcct gagacccgaa     2400

gacaccgggg tctatttttg tgcaagaggc tactataggt acgagggggc tatggactac     2460

tggggccaag ggaccccggt caccgtctcc tcaggctcga ccggtggggg agggtcgact     2520

atggaagaat ctcccgtagc cagtcagtct aaagctgaga aagactatga tgcagcgaag     2580

aaagatgcta agaatgcgaa aaaagcagta gaagatgctc aaaaggcttt agatgatgca     2640

aaagctgctc agaaaaaata tgacgaggat cagaagaaaa ctgaggagaa agccgcgcta     2700

gaaaaagcag cgtctgaaga gatggataag gcagtggcag cagttcaaca agcgtatcta     2760

gcctatcaac aagctacaga caaagccgca aaagacgcag cagataagat gatagatgaa     2820

gctaagaaac gcgaagaaga ggcaaaaact aaatttaata ctgttcgagc aatggtagtt     2880

cctgagccag agcagttggc tgagactaag aaaaaatcag aagaagctaa acaaaaagca     2940

ccagaactta ctaaaaaact agaagaagct aaagcaaaat tagaagaggc tgagaaaaaa     3000

gctactgaag ccaaacaaaa agtggatgct gaagaagtcg ctcctcaagc taaaatcgct     3060

gaattggaaa atcaagttca tagactagaa caagagctca aagagattga tgagtctgaa     3120

tcagaagatt atgctaaaga aggtttccgt gctcctcttc aatctaaatt ggatgccaaa     3180

aaagctaaac tatcaaaact tgaagagtta agtgataaga ttgatgagtt agacgctgaa     3240

attgcaaaac ttgaagatca acttaaagct gctgaagaaa acaataatgt agaagactac     3300

tttaaagaag gtttagagaa aactattgct gctaaaaaag ctgaattaga aaaaactgaa     3360

gctgacctta agaaagcagt taatgagcca gaaaaaccag ctccagctcc agaaactcca     3420

gccccagaac tcgagcacca ccaccaccac cactgagatc cggctgctaa caaagcccga     3480

aaggaagctg agttggctgc tgccaccgct gagcaataac tagcataacc ccttggggcc     3540

tctaaacggg tcttgagggg ttttgcggcc gcacgacaga aactcatctc agaagaggat     3600

ctgaatggcg ccgcacatca ccatcatcac cattgattct agagggccct attctatagt     3660

gtcacctaaa tgctagagct cgctgatcag cctcgactgt gccttctagt tgccagccat     3720

ctgttgtttg cccctccccc gtgccttcct tgaccctgga aggtgccact cccactgtcc     3780

tttcctaata aaatgaggaa attgcatcgc attgtctgag taggtgtcat tctattctgg     3840

ggggtggggt ggggcaggac agcaaggggg aggattggga agacaatagc aggcatgctg     3900

gggatgcggt gggctctatg gcttctgagg cggaaagaac cagctggggc tctagggggt     3960

atccccacgc gccctgtagc ggcgcattaa gcgcggcggg tgtggtggtt acgcgcagcg     4020

tgaccgctac acttgccagc gccctagcgc ccgctccttt cgctttcttc ccttcctttc     4080

tcgccacgtt cgccggcttt ccccgtcaag ctctaaatcg gggcatccct ttagggttcc     4140

gatttagtgc tttacggcac ctcgacccca aaaaacttga ttagggtgat ggttcacgta     4200

gtgggccatc gccctgatag acggtttttc gccctttgac gttggagtcc acgttcttta     4260

atagtggact cttgttccaa actggaacaa cactcaaccc tatctcggtc tattcttttg     4320

atttataagg gattttgggg atttcggcct attggttaaa aaatgagctg atttaacaaa     4380

aatttaacgc gaattaattc tgtggaatgt gtgtcagtta gggtgtggaa agtccccagg     4440

ctccccaggc aggcagaagt atgcaaagca tgcatctcaa ttagtcagca accaggtgtg     4500

gaaagtcccc aggctcccca gcaggcagaa gtatgcaaag catgcatctc aattagtcag     4560

caaccatagt cccgccccta actccgccca tcccgcccct aactccgccc agttccgccc     4620

attctccgcc ccatggctga ctaatttttt ttatttatgc agaggccgag gccgcctctg     4680

cctctgagct attccagaag tagtgaggag gcttttttgg aggcctaggc ttttgcaaaa     4740

agctcccggg agcttgtata tccattttcg gatctgatca agagacagga tgaggatcgt     4800

ttcgcatgat tgaacaagat ggattgcacg caggttctcc ggccgcttgg gtggagaggc     4860

tattcggcta tgactgggca caacagacaa tcggctgctc tgatgccgcc gtgttccggc     4920

tgtcagcgca ggggcgcccg gttctttttg tcaagaccga cctgtccggt gccctgaatg     4980

aactgcagga cgaggcagcg cggctatcgt ggctggccac gacgggcgtt ccttgcgcag     5040

ctgtgctcga cgttgtcact gaagcgggaa gggactggct gctattgggc gaagtgccgg     5100

ggcaggatct cctgtcatct caccttgctc ctgccgagaa agtatccatc atggctgatg     5160

caatgcggcg gctgcatacg cttgatccgg ctacctgccc attcgaccac caagcgaaac     5220

atcgcatcga gcgagcacgt actcggatgg aagccggtct tgtcgatcag gatgatctgg     5280

acgaagagca tcaggggctc gcgccagccg aactgttcgc caggctcaag gcgcgcatgc     5340

ccgacggcga ggatctcgtc gtgacccatg gcgatgcctg cttgccgaat atcatggtgg     5400

aaaatggccg cttttctgga ttcatcgact gtggccggct gggtgtggcg gaccgctatc     5460

aggacatagc gttggctacc cgtgatattg ctgaagagct tggcggcgaa tgggctgacc     5520

gcttcctcgt gctttacggt atcgccgctc ccgattcgca gcgcatcgcc ttctatcgcc     5580

ttcttgacga gttcttctga gcgggactct ggggttcgaa atgaccgacc aagcgacgcc     5640

caacctgcca tcacgagatt tcgattccac cgccgccttc tatgaaaggt tgggcttcgg     5700

aatcgttttc cgggacgccg gctggatgat cctccagcgc ggggatctca tgctggagtt     5760

cttcgcccac cccaacttgt ttattgcagc ttataatggt tacaaataaa gcaatagcat     5820

cacaaatttc acaaataaag catttttttc actgcattct agttgtggtt tgtccaaact     5880

catcaatgta tcttatcatg tctgtatacc gtcgacctct agctagagct tggcgtaatc     5940

atggtcatag ctgtttcctg tgtgaaattg ttatccgctc acaattccac acaacatacg     6000

agccggaagc ataaagtgta aagcctgggg tgcctaatga gtgagctaac tcacattaat     6060

tgcgttgcgc tcactgcccg ctttccagtc gggaaacctg tcgtgccagc tgcattaatg     6120

aatcggccaa cgcgcgggga gaggcggttt gcgtattggg cgctcttccg cttcctcgct     6180

cactgactcg ctgcgctcgg tcgttcggct gcggcgagcg gtatcagctc actcaaaggc     6240

ggtaatacgg ttatccacag aatcagggga taacgcagga aagaacatgt gagcaaaagg     6300

ccagcaaaag gccaggaacc gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg     6360

cccccctgac gagcatcaca aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg     6420

actataaaga taccaggcgt ttccccctgg aagctccctc gtgcgctctc ctgttccgac     6480

cctgccgctt accggatacc tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca     6540

atgctcacgc tgtaggtatc tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt     6600

gcacgaaccc cccgttcagc ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc     6660

caacccggta agacacgact tatcgccact ggcagcagcc actggtaaca ggattagcag     6720

agcgaggtat gtaggcggtg ctacagagtt cttgaagtgg tggcctaact acggctacac     6780

tagaaggaca gtatttggta tctgcgctct gctgaagcca gttaccttcg gaaaaagagt     6840

tggtagctct tgatccggca aacaaaccac cgctggtagc ggtggttttt ttgtttgcaa     6900

gcagcagatt acgcgcagaa aaaaaggatc tcaagaagat cctttgatct tttctacggg     6960

gtctgacgct cagtggaacg aaaactcacg ttaagggatt ttggtcatga gattatcaaa     7020

aaggatcttc acctagatcc ttttaaatta aaaatgaagt tttaaatcaa tctaaagtat     7080

atatgagtaa acttggtctg acagttacca atgcttaatc agtgaggcac ctatctcagc     7140

gatctgtcta tttcgttcat ccatagttgc ctgactcccc gtcgtgtaga taactacgat     7200

acgggagggc ttaccatctg gccccagtgc tgcaatgata ccgcgagacc cacgctcacc     7260

ggctccagat ttatcagcaa taaaccagcc agccggaagg gccgagcgca gaagtggtcc     7320

tgcaacttta tccgcctcca tccagtctat taattgttgc cgggaagcta gagtaagtag     7380

ttcgccagtt aatagtttgc gcaacgttgt tgccattgct acaggcatcg tggtgtcacg     7440

ctcgtcgttt ggtatggctt cattcagctc cggttcccaa cgatcaaggc gagttacatg     7500

atcccccatg ttgtgcaaaa aagcggttag ctccttcggt cctccgatcg ttgtcagaag     7560

taagttggcc gcagtgttat cactcatggt tatggcagca ctgcataatt ctcttactgt     7620

catgccatcc gtaagatgct tttctgtgac tggtgagtac tcaaccaagt cattctgaga     7680

atagtgtatg cggcgaccga gttgctcttg cccggcgtca atacgggata ataccgcgcc     7740

acatagcaga actttaaaag tgctcatcat tggaaaacgt tcttcggggc gaaaactctc     7800

aaggatctta ccgctgttga gatccagttc gatgtaaccc actcgtgcac ccaactgatc     7860

ttcagcatct tttactttca ccagcgtttc tgggtgagca aaaacaggaa ggcaaaatgc     7920

cgcaaaaaag ggaataaggg cgacacggaa atgttgaata ctcatactct tcctttttca     7980

atattattga agcatttatc agggttattg tctcatgagc ggatacatat ttgaatgtat     8040

ttagaaaaat aaacaaatag gggttccgcg cacatttccc cgaaaagtgc cacctgacgt     8100

cg                                                                    8102


<210>  22
<211>  7268
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Non-FcgR1 targeted PspA-HuSA

<400>  22
acggatcggg agatctcccg atcccctatg gtcgactctc agtacaatct gctctgatgc       60

cgcatagtta agccagtatc tgctccctgc ttgtgtgttg gaggtcgctg agtagtgcgc      120

gagcaaaatt taagctacaa caaggcaagg cttgaccgac aattgcatga agaatctgct      180

tagggttagg cgttttgcgc tgcttcgcga tgtacgggcc agatatacgc gttgacattg      240

attattgact agttattaat agtaatcaat tacggggtca ttagttcata gcccatatat      300

ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc      360

ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag ggactttcca      420

ttgacgtcaa tgggtggact atttacggta aactgcccac ttggcagtac atcaagtgta      480

tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg cctggcatta      540

tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg tattagtcat      600

cgctattacc atggtgatgc ggttttggca gtacatcaat gggcgtggat agcggtttga      660

ctcacgggga tttccaagtc tccaccccat tgacgtcaat gggagtttgt tttggcacca      720

aaatcaacgg gactttccaa aatgtcgtaa caactccgcc ccattgacgc aaatgggcgg      780

taggcgtgta cggtgggagg tctatataag cagagctctc tggctaacta gagaacccac      840

tgcttactgg cttatcgaaa ttaatacgac tcactatagg gagacccaag cttcaccatg      900

ggatggagct gtatcatcct cttcttggtg gccacagcta ccggtggggg aggctcgact      960

gctagcgaat tcatggaaga atctcccgta gccagtcagt ctaaagctga gaaagactat     1020

gatgcagcga agaaagatgc taagaatgcg aaaaaagcag tagaagatgc tcaaaaggct     1080

ttagatgatg caaaagctgc tcagaaaaaa tatgacgagg atcagaagaa aactgaggag     1140

aaagccgcgc tagaaaaagc agcgtctgaa gagatggata aggcagtggc agcagttcaa     1200

caagcgtatc tagcctatca acaagctaca gacaaagccg caaaagacgc agcagataag     1260

atgatagatg aagctaagaa acgcgaagaa gaggcaaaaa ctaaatttaa tactgttcga     1320

gcaatggtag ttcctgagcc agagcagttg gctgagacta agaaaaaatc agaagaagct     1380

aaacaaaaag caccagaact tactaaaaaa ctagaagaag ctaaagcaaa attagaagag     1440

gctgagaaaa aagctactga agccaaacaa aaagtggatg ctgaagaagt cgctcctcaa     1500

gctaaaatcg ctgaattgga aaatcaagtt catagactag aacaagagct caaagagatt     1560

gatgagtctg aatcagaaga ttatgctaaa gaaggtttcc gtgctcctct tcaatctaaa     1620

ttggatgcca aaaaagctaa actatcaaaa cttgaagagt taagtgataa gattgatgag     1680

ttagacgctg aaattgcaaa acttgaagat caacttaaag ctgctgaaga aaacaataat     1740

gtagaagact actttaaaga aggtttagag aaaactattg ctgctaaaaa agctgaatta     1800

gaaaaaactg aagctgacct taagaaagca gttaatgagc cagaaaaacc agctccagct     1860

ccagaaactc cagccccaga actcgagggt ggatcaggcg gttgtacact agagaagtgc     1920

tgtgccgctg cagatcctca tgaatgctat gccaaagtgt tcgatgaatt taaacctctt     1980

gtggaagagc ctcagaattt aatcaaacaa aattgtgagc tttttgagca gcttggagag     2040

tacaaattcc agaatgcgct attagttcgt tacaccaaga aagtacccca agtgtcaact     2100

ccaactcttg tagaggtctc aagaaaccta ggaaaagtgg gcagcaaatg ttgtaaacat     2160

cctgaagcaa aaagaatgcc ctgtgcagaa gactatctat ccgtggtcct gaaccagtta     2220

tgtgtgttgc atgagaaaac gccagtaagt gacagagtca ccaaatgctg cacagaatcc     2280

ttggtgaaca ggcgaccatg cttttcagct ctggaagtcg atgaaacata cgttcccaaa     2340

gagtttaatg ctgaaacatt caccttccat gcagatatat gcacactttc tgagaaggag     2400

agacaaatca agaaacaaac tgcacttgtt gagctcgtga aacacaagcc caaggcaaca     2460

aaagagcaac tgaaagctgt tatggatgat ttcgcagctt ttgtagagaa gtgctgcaag     2520

gctgacgata aggagacctg ctttgccgag gagggtaaaa aacttgttgc tgcaagtcaa     2580

gctgccttag gcttacgtac gcaccaccac caccaccact gagatccggc tgctaacaaa     2640

gcccgaaagg aagctgagtt ggctgctgcc accgctgagc aataactagc ataacccctt     2700

ggggcctcta aacgggtctt gaggggtttt gcggccgcac gacagaaact catctcagaa     2760

gaggatctga atggcgccgc acatcaccat catcaccatt gattctagag ggccctattc     2820

tatagtgtca cctaaatgct agagctcgct gatcagcctc gactgtgcct tctagttgcc     2880

agccatctgt tgtttgcccc tcccccgtgc cttccttgac cctggaaggt gccactccca     2940

ctgtcctttc ctaataaaat gaggaaattg catcgcattg tctgagtagg tgtcattcta     3000

ttctgggggg tggggtgggg caggacagca agggggagga ttgggaagac aatagcaggc     3060

atgctgggga tgcggtgggc tctatggctt ctgaggcgga aagaaccagc tggggctcta     3120

gggggtatcc ccacgcgccc tgtagcggcg cattaagcgc ggcgggtgtg gtggttacgc     3180

gcagcgtgac cgctacactt gccagcgccc tagcgcccgc tcctttcgct ttcttccctt     3240

cctttctcgc cacgttcgcc ggctttcccc gtcaagctct aaatcggggc atccctttag     3300

ggttccgatt tagtgcttta cggcacctcg accccaaaaa acttgattag ggtgatggtt     3360

cacgtagtgg gccatcgccc tgatagacgg tttttcgccc tttgacgttg gagtccacgt     3420

tctttaatag tggactcttg ttccaaactg gaacaacact caaccctatc tcggtctatt     3480

cttttgattt ataagggatt ttggggattt cggcctattg gttaaaaaat gagctgattt     3540

aacaaaaatt taacgcgaat taattctgtg gaatgtgtgt cagttagggt gtggaaagtc     3600

cccaggctcc ccaggcaggc agaagtatgc aaagcatgca tctcaattag tcagcaacca     3660

ggtgtggaaa gtccccaggc tccccagcag gcagaagtat gcaaagcatg catctcaatt     3720

agtcagcaac catagtcccg cccctaactc cgcccatccc gcccctaact ccgcccagtt     3780

ccgcccattc tccgccccat ggctgactaa ttttttttat ttatgcagag gccgaggccg     3840

cctctgcctc tgagctattc cagaagtagt gaggaggctt ttttggaggc ctaggctttt     3900

gcaaaaagct cccgggagct tgtatatcca ttttcggatc tgatcaagag acaggatgag     3960

gatcgtttcg catgattgaa caagatggat tgcacgcagg ttctccggcc gcttgggtgg     4020

agaggctatt cggctatgac tgggcacaac agacaatcgg ctgctctgat gccgccgtgt     4080

tccggctgtc agcgcagggg cgcccggttc tttttgtcaa gaccgacctg tccggtgccc     4140

tgaatgaact gcaggacgag gcagcgcggc tatcgtggct ggccacgacg ggcgttcctt     4200

gcgcagctgt gctcgacgtt gtcactgaag cgggaaggga ctggctgcta ttgggcgaag     4260

tgccggggca ggatctcctg tcatctcacc ttgctcctgc cgagaaagta tccatcatgg     4320

ctgatgcaat gcggcggctg catacgcttg atccggctac ctgcccattc gaccaccaag     4380

cgaaacatcg catcgagcga gcacgtactc ggatggaagc cggtcttgtc gatcaggatg     4440

atctggacga agagcatcag gggctcgcgc cagccgaact gttcgccagg ctcaaggcgc     4500

gcatgcccga cggcgaggat ctcgtcgtga cccatggcga tgcctgcttg ccgaatatca     4560

tggtggaaaa tggccgcttt tctggattca tcgactgtgg ccggctgggt gtggcggacc     4620

gctatcagga catagcgttg gctacccgtg atattgctga agagcttggc ggcgaatggg     4680

ctgaccgctt cctcgtgctt tacggtatcg ccgctcccga ttcgcagcgc atcgccttct     4740

atcgccttct tgacgagttc ttctgagcgg gactctgggg ttcgaaatga ccgaccaagc     4800

gacgcccaac ctgccatcac gagatttcga ttccaccgcc gccttctatg aaaggttggg     4860

cttcggaatc gttttccggg acgccggctg gatgatcctc cagcgcgggg atctcatgct     4920

ggagttcttc gcccacccca acttgtttat tgcagcttat aatggttaca aataaagcaa     4980

tagcatcaca aatttcacaa ataaagcatt tttttcactg cattctagtt gtggtttgtc     5040

caaactcatc aatgtatctt atcatgtctg tataccgtcg acctctagct agagcttggc     5100

gtaatcatgg tcatagctgt ttcctgtgtg aaattgttat ccgctcacaa ttccacacaa     5160

catacgagcc ggaagcataa agtgtaaagc ctggggtgcc taatgagtga gctaactcac     5220

attaattgcg ttgcgctcac tgcccgcttt ccagtcggga aacctgtcgt gccagctgca     5280

ttaatgaatc ggccaacgcg cggggagagg cggtttgcgt attgggcgct cttccgcttc     5340

ctcgctcact gactcgctgc gctcggtcgt tcggctgcgg cgagcggtat cagctcactc     5400

aaaggcggta atacggttat ccacagaatc aggggataac gcaggaaaga acatgtgagc     5460

aaaaggccag caaaaggcca ggaaccgtaa aaaggccgcg ttgctggcgt ttttccatag     5520

gctccgcccc cctgacgagc atcacaaaaa tcgacgctca agtcagaggt ggcgaaaccc     5580

gacaggacta taaagatacc aggcgtttcc ccctggaagc tccctcgtgc gctctcctgt     5640

tccgaccctg ccgcttaccg gatacctgtc cgcctttctc ccttcgggaa gcgtggcgct     5700

ttctcaatgc tcacgctgta ggtatctcag ttcggtgtag gtcgttcgct ccaagctggg     5760

ctgtgtgcac gaaccccccg ttcagcccga ccgctgcgcc ttatccggta actatcgtct     5820

tgagtccaac ccggtaagac acgacttatc gccactggca gcagccactg gtaacaggat     5880

tagcagagcg aggtatgtag gcggtgctac agagttcttg aagtggtggc ctaactacgg     5940

ctacactaga aggacagtat ttggtatctg cgctctgctg aagccagtta ccttcggaaa     6000

aagagttggt agctcttgat ccggcaaaca aaccaccgct ggtagcggtg gtttttttgt     6060

ttgcaagcag cagattacgc gcagaaaaaa aggatctcaa gaagatcctt tgatcttttc     6120

tacggggtct gacgctcagt ggaacgaaaa ctcacgttaa gggattttgg tcatgagatt     6180

atcaaaaagg atcttcacct agatcctttt aaattaaaaa tgaagtttta aatcaatcta     6240

aagtatatat gagtaaactt ggtctgacag ttaccaatgc ttaatcagtg aggcacctat     6300

ctcagcgatc tgtctatttc gttcatccat agttgcctga ctccccgtcg tgtagataac     6360

tacgatacgg gagggcttac catctggccc cagtgctgca atgataccgc gagacccacg     6420

ctcaccggct ccagatttat cagcaataaa ccagccagcc ggaagggccg agcgcagaag     6480

tggtcctgca actttatccg cctccatcca gtctattaat tgttgccggg aagctagagt     6540

aagtagttcg ccagttaata gtttgcgcaa cgttgttgcc attgctacag gcatcgtggt     6600

gtcacgctcg tcgtttggta tggcttcatt cagctccggt tcccaacgat caaggcgagt     6660

tacatgatcc cccatgttgt gcaaaaaagc ggttagctcc ttcggtcctc cgatcgttgt     6720

cagaagtaag ttggccgcag tgttatcact catggttatg gcagcactgc ataattctct     6780

tactgtcatg ccatccgtaa gatgcttttc tgtgactggt gagtactcaa ccaagtcatt     6840

ctgagaatag tgtatgcggc gaccgagttg ctcttgcccg gcgtcaatac gggataatac     6900

cgcgccacat agcagaactt taaaagtgct catcattgga aaacgttctt cggggcgaaa     6960

actctcaagg atcttaccgc tgttgagatc cagttcgatg taacccactc gtgcacccaa     7020

ctgatcttca gcatctttta ctttcaccag cgtttctggg tgagcaaaaa caggaaggca     7080

aaatgccgca aaaaagggaa taagggcgac acggaaatgt tgaatactca tactcttcct     7140

ttttcaatat tattgaagca tttatcaggg ttattgtctc atgagcggat acatatttga     7200

atgtatttag aaaaataaac aaataggggt tccgcgcaca tttccccgaa aagtgccacc     7260

tgacgtcg                                                              7268


<210>  23
<211>  8834
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Bivalent anti FcgR1-PspA-HuSA

<400>  23
acggatcggg agatctcccg atcccctatg gtcgactctc agtacaatct gctctgatgc       60

cgcatagtta agccagtatc tgctccctgc ttgtgtgttg gaggtcgctg agtagtgcgc      120

gagcaaaatt taagctacaa caaggcaagg cttgaccgac aattgcatga agaatctgct      180

tagggttagg cgttttgcgc tgcttcgcga tgtacgggcc agatatacgc gttgacattg      240

attattgact agttattaat agtaatcaat tacggggtca ttagttcata gcccatatat      300

ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc      360

ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag ggactttcca      420

ttgacgtcaa tgggtggact atttacggta aactgcccac ttggcagtac atcaagtgta      480

tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg cctggcatta      540

tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg tattagtcat      600

cgctattacc atggtgatgc ggttttggca gtacatcaat gggcgtggat agcggtttga      660

ctcacgggga tttccaagtc tccaccccat tgacgtcaat gggagtttgt tttggcacca      720

aaatcaacgg gactttccaa aatgtcgtaa caactccgcc ccattgacgc aaatgggcgg      780

taggcgtgta cggtgggagg tctatataag cagagctctc tggctaacta gagaacccac      840

tgcttactgg cttatcgaaa ttaatacgac tcactatagg gagacccaag cttcaccatg      900

ggatggagct gtatcatcct cttcttggtg gccacagcta ccggtgtcca ctccgatatc      960

cagctgaccc agagcccaag cagcctgagc gccagcgtgg gtgacagagt gaccatcacc     1020

tgtaagtcca gtcaaagtgt tttatacagt tcaaatcaga agaactactt ggcctggtac     1080

cagcagaagc caggtaaggc tccaaagctg ctgatctact gggcatccac tagggaatct     1140

ggtgtgccaa gcagattcag cggtagcggt agcggtaccg acttcacctt caccatcagc     1200

agcctccagc cagaggacat cgccacctac tactgccatc aatacctctc ctcgtggacg     1260

ttcggccaag ggaccaaggt ggaaatcaag agctctggcg gtggcggctc cggaggtgga     1320

ggcagcggag ggggtggatc cgaggtccaa ctggtggaga gcggtggagg tgttgtgcaa     1380

cctggccggt ccctgcgcct gtcctgctcc tcgtctggct tcattttcag tgacaattac     1440

atgtattggg tgagacaggc acctggaaaa ggtcttgagt gggttgcaac cattagtgat     1500

ggtggtagtt acacctacta tccagacagt gtgaagggaa gatttacaat atcgagagac     1560

aacagcaaga acacattgtt cctgcaaatg gacagcctga gacccgaaga caccggggtc     1620

tatttttgtg caagaggcta ctataggtac gagggggcta tggactactg gggccaaggg     1680

accccggtca ccgtctcctc aggctcgacc ggtgggggag gctcgaccag cgctggaggc     1740

ggaggttcta gtgacatcca gctgacccag agcccaagca gcctgagcgc cagcgtgggt     1800

gacagagtga ccatcacctg taagtccagt caaagtgttt tatacagttc aaatcagaag     1860

aactacttgg cctggtacca gcagaagcca ggtaaggctc caaagctgct gatctactgg     1920

gcatccacta gggaatctgg tgtgccaagc agattcagcg gtagcggtag cggtaccgac     1980

ttcaccttca ccatcagcag cctccagcca gaggacatcg ccacctacta ctgccatcaa     2040

tacctctcct cgtggacgtt cggccaaggg accaaggtgg aaatcaagag ctctggcggt     2100

ggcggctccg gaggtggagg cagcggaggg ggtggatccg aggtccaact ggtggagagc     2160

ggtggaggtg ttgtgcaacc tggccggtcc ctgcgcctgt cctgctcctc gtctggcttc     2220

attttcagtg acaattacat gtattgggtg agacaggcac ctggaaaagg tcttgagtgg     2280

gttgcaacca ttagtgatgg tggtagttac acctactatc cagacagtgt gaagggaaga     2340

tttacaatat cgagagacaa cagcaagaac acattgttcc tgcaaatgga cagcctgaga     2400

cccgaagaca ccggggtcta tttttgtgca agaggctact ataggtacga gggggctatg     2460

gactactggg gccaagggac cccggtcacc gtctcctcag gctcgaccgg tgggggaggc     2520

tcgactgcta gcgaattcat ggaagaatct cccgtagcca gtcagtctaa agctgagaaa     2580

gactatgatg cagcgaagaa agatgctaag aatgcgaaaa aagcagtaga agatgctcaa     2640

aaggctttag atgatgcaaa agctgctcag aaaaaatatg acgaggatca gaagaaaact     2700

gaggagaaag ccgcgctaga aaaagcagcg tctgaagaga tggataaggc agtggcagca     2760

gttcaacaag cgtatctagc ctatcaacaa gctacagaca aagccgcaaa agacgcagca     2820

gataagatga tagatgaagc taagaaacgc gaagaagagg caaaaactaa atttaatact     2880

gttcgagcaa tggtagttcc tgagccagag cagttggctg agactaagaa aaaatcagaa     2940

gaagctaaac aaaaagcacc agaacttact aaaaaactag aagaagctaa agcaaaatta     3000

gaagaggctg agaaaaaagc tactgaagcc aaacaaaaag tggatgctga agaagtcgct     3060

cctcaagcta aaatcgctga attggaaaat caagttcata gactagaaca agagctcaaa     3120

gagattgatg agtctgaatc agaagattat gctaaagaag gtttccgtgc tcctcttcaa     3180

tctaaattgg atgccaaaaa agctaaacta tcaaaacttg aagagttaag tgataagatt     3240

gatgagttag acgctgaaat tgcaaaactt gaagatcaac ttaaagctgc tgaagaaaac     3300

aataatgtag aagactactt taaagaaggt ttagagaaaa ctattgctgc taaaaaagct     3360

gaattagaaa aaactgaagc tgaccttaag aaagcagtta atgagccaga aaaaccagct     3420

ccagctccag aaactccagc cccagaactc gagggtggat caggcggttg tacactagag     3480

aagtgctgtg ccgctgcaga tcctcatgaa tgctatgcca aagtgttcga tgaatttaaa     3540

cctcttgtgg aagagcctca gaatttaatc aaacaaaatt gtgagctttt tgagcagctt     3600

ggagagtaca aattccagaa tgcgctatta gttcgttaca ccaagaaagt accccaagtg     3660

tcaactccaa ctcttgtaga ggtctcaaga aacctaggaa aagtgggcag caaatgttgt     3720

aaacatcctg aagcaaaaag aatgccctgt gcagaagact atctatccgt ggtcctgaac     3780

cagttatgtg tgttgcatga gaaaacgcca gtaagtgaca gagtcaccaa atgctgcaca     3840

gaatccttgg tgaacaggcg accatgcttt tcagctctgg aagtcgatga aacatacgtt     3900

cccaaagagt ttaatgctga aacattcacc ttccatgcag atatatgcac actttctgag     3960

aaggagagac aaatcaagaa acaaactgca cttgttgagc tcgtgaaaca caagcccaag     4020

gcaacaaaag agcaactgaa agctgttatg gatgatttcg cagcttttgt agagaagtgc     4080

tgcaaggctg acgataagga gacctgcttt gccgaggagg gtaaaaaact tgttgctgca     4140

agtcaagctg ccttaggctt acgtacgcac caccaccacc accactgaga tccggctgct     4200

aacaaagccc gaaaggaagc tgagttggct gctgccaccg ctgagcaata actagcataa     4260

ccccttgggg cctctaaacg ggtcttgagg ggttttgcgg ccgcacgaca gaaactcatc     4320

tcagaagagg atctgaatgg cgccgcacat caccatcatc accattgatt ctagagggcc     4380

ctattctata gtgtcaccta aatgctagag ctcgctgatc agcctcgact gtgccttcta     4440

gttgccagcc atctgttgtt tgcccctccc ccgtgccttc cttgaccctg gaaggtgcca     4500

ctcccactgt cctttcctaa taaaatgagg aaattgcatc gcattgtctg agtaggtgtc     4560

attctattct ggggggtggg gtggggcagg acagcaaggg ggaggattgg gaagacaata     4620

gcaggcatgc tggggatgcg gtgggctcta tggcttctga ggcggaaaga accagctggg     4680

gctctagggg gtatccccac gcgccctgta gcggcgcatt aagcgcggcg ggtgtggtgg     4740

ttacgcgcag cgtgaccgct acacttgcca gcgccctagc gcccgctcct ttcgctttct     4800

tcccttcctt tctcgccacg ttcgccggct ttccccgtca agctctaaat cggggcatcc     4860

ctttagggtt ccgatttagt gctttacggc acctcgaccc caaaaaactt gattagggtg     4920

atggttcacg tagtgggcca tcgccctgat agacggtttt tcgccctttg acgttggagt     4980

ccacgttctt taatagtgga ctcttgttcc aaactggaac aacactcaac cctatctcgg     5040

tctattcttt tgatttataa gggattttgg ggatttcggc ctattggtta aaaaatgagc     5100

tgatttaaca aaaatttaac gcgaattaat tctgtggaat gtgtgtcagt tagggtgtgg     5160

aaagtcccca ggctccccag gcaggcagaa gtatgcaaag catgcatctc aattagtcag     5220

caaccaggtg tggaaagtcc ccaggctccc cagcaggcag aagtatgcaa agcatgcatc     5280

tcaattagtc agcaaccata gtcccgcccc taactccgcc catcccgccc ctaactccgc     5340

ccagttccgc ccattctccg ccccatggct gactaatttt ttttatttat gcagaggccg     5400

aggccgcctc tgcctctgag ctattccaga agtagtgagg aggctttttt ggaggcctag     5460

gcttttgcaa aaagctcccg ggagcttgta tatccatttt cggatctgat caagagacag     5520

gatgaggatc gtttcgcatg attgaacaag atggattgca cgcaggttct ccggccgctt     5580

gggtggagag gctattcggc tatgactggg cacaacagac aatcggctgc tctgatgccg     5640

ccgtgttccg gctgtcagcg caggggcgcc cggttctttt tgtcaagacc gacctgtccg     5700

gtgccctgaa tgaactgcag gacgaggcag cgcggctatc gtggctggcc acgacgggcg     5760

ttccttgcgc agctgtgctc gacgttgtca ctgaagcggg aagggactgg ctgctattgg     5820

gcgaagtgcc ggggcaggat ctcctgtcat ctcaccttgc tcctgccgag aaagtatcca     5880

tcatggctga tgcaatgcgg cggctgcata cgcttgatcc ggctacctgc ccattcgacc     5940

accaagcgaa acatcgcatc gagcgagcac gtactcggat ggaagccggt cttgtcgatc     6000

aggatgatct ggacgaagag catcaggggc tcgcgccagc cgaactgttc gccaggctca     6060

aggcgcgcat gcccgacggc gaggatctcg tcgtgaccca tggcgatgcc tgcttgccga     6120

atatcatggt ggaaaatggc cgcttttctg gattcatcga ctgtggccgg ctgggtgtgg     6180

cggaccgcta tcaggacata gcgttggcta cccgtgatat tgctgaagag cttggcggcg     6240

aatgggctga ccgcttcctc gtgctttacg gtatcgccgc tcccgattcg cagcgcatcg     6300

ccttctatcg ccttcttgac gagttcttct gagcgggact ctggggttcg aaatgaccga     6360

ccaagcgacg cccaacctgc catcacgaga tttcgattcc accgccgcct tctatgaaag     6420

gttgggcttc ggaatcgttt tccgggacgc cggctggatg atcctccagc gcggggatct     6480

catgctggag ttcttcgccc accccaactt gtttattgca gcttataatg gttacaaata     6540

aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg     6600

tttgtccaaa ctcatcaatg tatcttatca tgtctgtata ccgtcgacct ctagctagag     6660

cttggcgtaa tcatggtcat agctgtttcc tgtgtgaaat tgttatccgc tcacaattcc     6720

acacaacata cgagccggaa gcataaagtg taaagcctgg ggtgcctaat gagtgagcta     6780

actcacatta attgcgttgc gctcactgcc cgctttccag tcgggaaacc tgtcgtgcca     6840

gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt ttgcgtattg ggcgctcttc     6900

cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg ctgcggcgag cggtatcagc     6960

tcactcaaag gcggtaatac ggttatccac agaatcaggg gataacgcag gaaagaacat     7020

gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag gccgcgttgc tggcgttttt     7080

ccataggctc cgcccccctg acgagcatca caaaaatcga cgctcaagtc agaggtggcg     7140

aaacccgaca ggactataaa gataccaggc gtttccccct ggaagctccc tcgtgcgctc     7200

tcctgttccg accctgccgc ttaccggata cctgtccgcc tttctccctt cgggaagcgt     7260

ggcgctttct caatgctcac gctgtaggta tctcagttcg gtgtaggtcg ttcgctccaa     7320

gctgggctgt gtgcacgaac cccccgttca gcccgaccgc tgcgccttat ccggtaacta     7380

tcgtcttgag tccaacccgg taagacacga cttatcgcca ctggcagcag ccactggtaa     7440

caggattagc agagcgaggt atgtaggcgg tgctacagag ttcttgaagt ggtggcctaa     7500

ctacggctac actagaagga cagtatttgg tatctgcgct ctgctgaagc cagttacctt     7560

cggaaaaaga gttggtagct cttgatccgg caaacaaacc accgctggta gcggtggttt     7620

ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag atcctttgat     7680

cttttctacg gggtctgacg ctcagtggaa cgaaaactca cgttaaggga ttttggtcat     7740

gagattatca aaaaggatct tcacctagat ccttttaaat taaaaatgaa gttttaaatc     7800

aatctaaagt atatatgagt aaacttggtc tgacagttac caatgcttaa tcagtgaggc     7860

acctatctca gcgatctgtc tatttcgttc atccatagtt gcctgactcc ccgtcgtgta     7920

gataactacg atacgggagg gcttaccatc tggccccagt gctgcaatga taccgcgaga     7980

cccacgctca ccggctccag atttatcagc aataaaccag ccagccggaa gggccgagcg     8040

cagaagtggt cctgcaactt tatccgcctc catccagtct attaattgtt gccgggaagc     8100

tagagtaagt agttcgccag ttaatagttt gcgcaacgtt gttgccattg ctacaggcat     8160

cgtggtgtca cgctcgtcgt ttggtatggc ttcattcagc tccggttccc aacgatcaag     8220

gcgagttaca tgatccccca tgttgtgcaa aaaagcggtt agctccttcg gtcctccgat     8280

cgttgtcaga agtaagttgg ccgcagtgtt atcactcatg gttatggcag cactgcataa     8340

ttctcttact gtcatgccat ccgtaagatg cttttctgtg actggtgagt actcaaccaa     8400

gtcattctga gaatagtgta tgcggcgacc gagttgctct tgcccggcgt caatacggga     8460

taataccgcg ccacatagca gaactttaaa agtgctcatc attggaaaac gttcttcggg     8520

gcgaaaactc tcaaggatct taccgctgtt gagatccagt tcgatgtaac ccactcgtgc     8580

acccaactga tcttcagcat cttttacttt caccagcgtt tctgggtgag caaaaacagg     8640

aaggcaaaat gccgcaaaaa agggaataag ggcgacacgg aaatgttgaa tactcatact     8700

cttccttttt caatattatt gaagcattta tcagggttat tgtctcatga gcggatacat     8760

atttgaatgt atttagaaaa ataaacaaat aggggttccg cgcacatttc cccgaaaagt     8820

gccacctgac gtcg                                                       8834


<210>  24
<211>  258
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Anti-FcgR1 sequence

<400>  24

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys His Gln 
                85                  90                  95      


Tyr Leu Ser Ser Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
    130                 135                 140                 


Arg Ser Leu Arg Leu Ser Cys Ser Ser Ser Gly Phe Ile Phe Ser Asp 
145                 150                 155                 160 


Asn Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
                165                 170                 175     


Val Ala Thr Ile Ser Asp Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser 
            180                 185                 190         


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
        195                 200                 205             


Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe 
    210                 215                 220                 


Cys Ala Arg Gly Tyr Tyr Arg Tyr Glu Gly Ala Met Asp Tyr Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Pro Val Thr Val Ser Ser Gly Ser Thr Gly Gly Gly Gly 
                245                 250                 255     


Ser Thr 
        


<210>  25
<211>  229
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human Serum Albumin fragment (FcRn binding)

<400>  25

Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys 
1               5                   10                  15      


Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile 
            20                  25                  30          


Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln 
        35                  40                  45              


Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr 
    50                  55                  60                  


Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys 
65                  70                  75                  80  


Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr 
                85                  90                  95      


Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro 
            100                 105                 110         


Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg 
        115                 120                 125             


Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys 
    130                 135                 140                 


Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu 
145                 150                 155                 160 


Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu 
                165                 170                 175     


Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met 
            180                 185                 190         


Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys 
        195                 200                 205             


Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln 
    210                 215                 220                 


Ala Ala Leu Gly Leu 
225                 


