                         SEQUENCE LISTING

<110>  E.I. du Pont de Nemours & Company, Inc.
       Payne, Mark
       Scholz, Thomas
       Brun, Yefim
       Paullin, Jayme
       Nambiar, Rakesh
       Dennes, Joseph
 
<120>  GLUCOSYLTRANSFERASE ENZYMES FOR PRODUCTION OF GLUCAN POLYMERS

<130>  CL6201

<150>  US 61/939,811
<151>  2014-02-14

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  4047
<212>  DNA
<213>  Streptococcus oralis

<400>  1
atgatcgacg gcaaaaacta ctacgtacag gatgatggca cggtaaagaa gaatttcgcg       60

gtagaactga atggtcgtat cctgtatttt gatgcagaaa ccggcgctct ggttgatagc      120

aacgagtatc agttccaaca gggtacgagc agcctgaaca atgaattttc tcagaagaac      180

gcattctatg gtacgaccga taaggatatt gagactgtgg atggctacct gaccgcagat      240

agctggtatc gcccgaaatt catcctgaag gatggcaaga cgtggaccgc gagcacggaa      300

acggatctgc gtccgctgtt gatggcatgg tggccggaca agcgtaccca aatcaactat      360

ctgaactaca tgaaccagca gggtctgggt gcgggtgcgt ttgagaacaa agtggagcag      420

gccctgctga cgggtgcaag ccaacaggta caacgcaaga tcgaagagaa gattggtaaa      480

gagggtgata ccaagtggct gcgcaccctg atgggtgcgt tcgtgaaaac gcaaccaaac      540

tggaatatca aaaccgagtc tgaaacgacc ggcacgaaaa aggaccatct gcaaggcggt      600

gcactgctgt atacgaacaa cgagaaatcc ccgcacgcgg acagcaaatt tcgtctgctg      660

aatcgtaccc cgaccagcca aaccggcacg ccgaagtatt tcatcgacaa gtctaacggt      720

ggctacgaat ttctgctggc gaacgatttt gacaatagca atcctgcggt acaagctgag      780

cagctgaatt ggctgcacta catgatgaac tttggcagca ttgttgcgaa tgatccgacc      840

gcgaatttcg acggcgttcg tgtggatgct gttgataacg tcaatgcgga cttgttgcaa      900

attgcaagcg attactttaa gagccgttac aaagtcggtg agagcgaaga agaagcgatc      960

aagcacctgt ccatcctgga agcatggagc gataacgacc cggactacaa caaagatacc     1020

aagggtgcac agttggcgat tgataacaaa ctgcgcctga gcctgctgta ctctttcatg     1080

cgtaatctga gcatccgtag cggtgttgaa ccgacgatta ccaatagcct gaatgaccgt     1140

tccagcgaaa agaagaacgg cgagcgtatg gcaaattaca tcttcgtgcg tgcccacgat     1200

agcgaggtcc aaacggtgat cgccgacatc attcgcgaaa acatcaatcc gaacaccgac     1260

ggcctgacgt ttacgatgga cgagctgaag caggcattca agatttacaa cgaggacatg     1320

cgcaaggcgg acaaaaagta tacccagttt aacattccta ccgcacacgc gctgatgctg     1380

tctaataagg attctattac ccgcgtgtac tatggtgatc tgtatactga cgatggtcag     1440

tacatggaga agaaaagccc gtatcacgat gcgattgacg ctctgctgcg tgcacgtatt     1500

aaatacgtcg cgggtggcca ggatatgaaa gtgacctata tgggcgtgcc gcgtgaagcg     1560

gataagtgga gctataacgg cattctgacc agcgtgcgct atggcacggg cgctaacgaa     1620

gccacggatg agggcactgc ggaaacgcgc acgcaaggta tggcagtgat tgcgagcaat     1680

aatccaaatc tgaaactgaa tgaatgggac aagttgcaag tcaacatggg tgcggcgcat     1740

aagaatcaat attaccgtcc ggttctgctg accactaagg acggtatcag ccgttatctg     1800

accgatgaag aagtgcctca gagcctgtgg aaaaagacgg acgcaaacgg tattctgacc     1860

ttcgacatga atgatattgc tggctacagc aacgtgcaag ttagcggtta cctggccgtc     1920

tgggtcccgg tcggtgcgaa ggcggatcaa gatgcgcgca cgaccgcatc caagaagaaa     1980

aatgcgtcgg gtcaggtgta cgaaagcagc gcggctctgg atagccagct gatttacgaa     2040

ggtttcagca actttcaaga ctttgccact cgcgatgatc agtacacgaa caaggtcatt     2100

gcgaaaaacg tgaatctgtt caaagaatgg ggtgtgacca gcttcgagct gccgccgcag     2160

tacgtgagca gccaagatgg cacctttctg gacagcatta tccaaaacgg ctatgcattt     2220

gaagaccgtt acgatatggc gatgagcaag aataacaagt atggtagcct gaaagacctg     2280

ttgaacgcgc tgcgcgcact gcacagcgtc aacattcaag caatcgccga ttgggtgccg     2340

gaccaaattt acaacttgcc gggcaaagag gtggtgaccg caactcgtgt caacaactac     2400

ggcacctacc gtgagggtgc tgaaatcaaa gaaaagctgt atgtcgccaa tagcaagacc     2460

aacgaaaccg atttccaagg taaatacggt ggtgcgttcc tggatgagct gaaggcgaag     2520

tacccggaga ttttcgagcg tgtccaaatc agcaacggcc aaaagatgac taccgatgaa     2580

aagatcacca aatggagcgc gaaatacttt aatggcacca atattctggg tcgtggcgcg     2640

tactatgtcc tgaaagattg ggccagcaat gattacctga cgaaccgtaa cggcgagatt     2700

gttttgccga agcaactggt taacaagaat agctataccg gctttgtcag cgacgcgaac     2760

ggcacgaagt tctattctac ctctggctac caggcgaaga acagcttcat tcaagacgaa     2820

aacggtaatt ggtattactt tgacaaacgt ggttatctgg ttacgggcgc acacgagatt     2880

gatggcaagc atgtctactt cctgaaaaac ggtatccaac tgcgtgacag catccgtgag     2940

gatgagaacg gtaatcaata ctattacgac cagaccggcg cacaagtgct gaaccgttac     3000

tacacgacgg acggtcagaa ttggcgctat ttcgatgcga aaggtgttat ggcacgcggc     3060

ctggtaaaga ttggtgacgg ccaacagttt ttcgatgaaa acggttacca ggtcaagggc     3120

aagattgtta gcgcaaaaga cggcaagctg cgctactttg ataaagactc tggcaatgct     3180

gtcattaatc gtttcgcgca gggtgacaat ccgagcgact ggtactattt cggtgtggaa     3240

tttgctaaac tgacgggttt gcaaaagatc ggccagcaga cgctgtattt tgaccaagac     3300

ggtaagcaag tcaaaggtaa gatcgtaact ctgtcggaca aaagcattcg ttacttcgat     3360

gccaacagcg gtgaaatggc ggttggcaag ttcgcggaag gtgcaaagaa tgagtggtat     3420

tatttcgata aaaccggcaa agcggttact ggtttgcaga aaattggtaa gcagaccctg     3480

tactttgacc aggacggtaa acaggttaaa ggcaaggttg tcacgctggc tgataaaagc     3540

atccgctact tcgacgcaga ctccggcgag atggcggtcg gtaagtttgc agagggtgcg     3600

aagaacgagt ggtactattt tgatcagact ggcaaggccg tgactggttt gcaaaagatt     3660

gacaagcaaa ccttgtactt cgaccaggac ggtaaacaag tcaagggtaa gattgtgacg     3720

ttgagcgaca agtcgatccg ttactttgat gctaatagcg gtgagatggc tactaacaaa     3780

ttcgtcgagg gctcgcagaa tgaatggtac tacttcgatc aagcgggtaa ggctgttacg     3840

ggcttgcaac aggtcggtca gcaaactctg tacttcaccc aggatggtaa gcaagtgaag     3900

ggtaaggtcg tggacgtgaa cggtgtttct cgttatttcg acgcaaactc cggtgacatg     3960

gctcgttcta aatggattca actggaagat ggcagctgga tgtatttcga ccgtgacggt     4020

cgtggccaga attttggccg taactaa                                         4047


<210>  2
<211>  1348
<212>  PRT
<213>  Streptococcus oralis

<400>  2

Met Ile Asp Gly Lys Asn Tyr Tyr Val Gln Asp Asp Gly Thr Val Lys 
1               5                   10                  15      


Lys Asn Phe Ala Val Glu Leu Asn Gly Arg Ile Leu Tyr Phe Asp Ala 
            20                  25                  30          


Glu Thr Gly Ala Leu Val Asp Ser Asn Glu Tyr Gln Phe Gln Gln Gly 
        35                  40                  45              


Thr Ser Ser Leu Asn Asn Glu Phe Ser Gln Lys Asn Ala Phe Tyr Gly 
    50                  55                  60                  


Thr Thr Asp Lys Asp Ile Glu Thr Val Asp Gly Tyr Leu Thr Ala Asp 
65                  70                  75                  80  


Ser Trp Tyr Arg Pro Lys Phe Ile Leu Lys Asp Gly Lys Thr Trp Thr 
                85                  90                  95      


Ala Ser Thr Glu Thr Asp Leu Arg Pro Leu Leu Met Ala Trp Trp Pro 
            100                 105                 110         


Asp Lys Arg Thr Gln Ile Asn Tyr Leu Asn Tyr Met Asn Gln Gln Gly 
        115                 120                 125             


Leu Gly Ala Gly Ala Phe Glu Asn Lys Val Glu Gln Ala Leu Leu Thr 
    130                 135                 140                 


Gly Ala Ser Gln Gln Val Gln Arg Lys Ile Glu Glu Lys Ile Gly Lys 
145                 150                 155                 160 


Glu Gly Asp Thr Lys Trp Leu Arg Thr Leu Met Gly Ala Phe Val Lys 
                165                 170                 175     


Thr Gln Pro Asn Trp Asn Ile Lys Thr Glu Ser Glu Thr Thr Gly Thr 
            180                 185                 190         


Lys Lys Asp His Leu Gln Gly Gly Ala Leu Leu Tyr Thr Asn Asn Glu 
        195                 200                 205             


Lys Ser Pro His Ala Asp Ser Lys Phe Arg Leu Leu Asn Arg Thr Pro 
    210                 215                 220                 


Thr Ser Gln Thr Gly Thr Pro Lys Tyr Phe Ile Asp Lys Ser Asn Gly 
225                 230                 235                 240 


Gly Tyr Glu Phe Leu Leu Ala Asn Asp Phe Asp Asn Ser Asn Pro Ala 
                245                 250                 255     


Val Gln Ala Glu Gln Leu Asn Trp Leu His Tyr Met Met Asn Phe Gly 
            260                 265                 270         


Ser Ile Val Ala Asn Asp Pro Thr Ala Asn Phe Asp Gly Val Arg Val 
        275                 280                 285             


Asp Ala Val Asp Asn Val Asn Ala Asp Leu Leu Gln Ile Ala Ser Asp 
    290                 295                 300                 


Tyr Phe Lys Ser Arg Tyr Lys Val Gly Glu Ser Glu Glu Glu Ala Ile 
305                 310                 315                 320 


Lys His Leu Ser Ile Leu Glu Ala Trp Ser Asp Asn Asp Pro Asp Tyr 
                325                 330                 335     


Asn Lys Asp Thr Lys Gly Ala Gln Leu Ala Ile Asp Asn Lys Leu Arg 
            340                 345                 350         


Leu Ser Leu Leu Tyr Ser Phe Met Arg Asn Leu Ser Ile Arg Ser Gly 
        355                 360                 365             


Val Glu Pro Thr Ile Thr Asn Ser Leu Asn Asp Arg Ser Ser Glu Lys 
    370                 375                 380                 


Lys Asn Gly Glu Arg Met Ala Asn Tyr Ile Phe Val Arg Ala His Asp 
385                 390                 395                 400 


Ser Glu Val Gln Thr Val Ile Ala Asp Ile Ile Arg Glu Asn Ile Asn 
                405                 410                 415     


Pro Asn Thr Asp Gly Leu Thr Phe Thr Met Asp Glu Leu Lys Gln Ala 
            420                 425                 430         


Phe Lys Ile Tyr Asn Glu Asp Met Arg Lys Ala Asp Lys Lys Tyr Thr 
        435                 440                 445             


Gln Phe Asn Ile Pro Thr Ala His Ala Leu Met Leu Ser Asn Lys Asp 
    450                 455                 460                 


Ser Ile Thr Arg Val Tyr Tyr Gly Asp Leu Tyr Thr Asp Asp Gly Gln 
465                 470                 475                 480 


Tyr Met Glu Lys Lys Ser Pro Tyr His Asp Ala Ile Asp Ala Leu Leu 
                485                 490                 495     


Arg Ala Arg Ile Lys Tyr Val Ala Gly Gly Gln Asp Met Lys Val Thr 
            500                 505                 510         


Tyr Met Gly Val Pro Arg Glu Ala Asp Lys Trp Ser Tyr Asn Gly Ile 
        515                 520                 525             


Leu Thr Ser Val Arg Tyr Gly Thr Gly Ala Asn Glu Ala Thr Asp Glu 
    530                 535                 540                 


Gly Thr Ala Glu Thr Arg Thr Gln Gly Met Ala Val Ile Ala Ser Asn 
545                 550                 555                 560 


Asn Pro Asn Leu Lys Leu Asn Glu Trp Asp Lys Leu Gln Val Asn Met 
                565                 570                 575     


Gly Ala Ala His Lys Asn Gln Tyr Tyr Arg Pro Val Leu Leu Thr Thr 
            580                 585                 590         


Lys Asp Gly Ile Ser Arg Tyr Leu Thr Asp Glu Glu Val Pro Gln Ser 
        595                 600                 605             


Leu Trp Lys Lys Thr Asp Ala Asn Gly Ile Leu Thr Phe Asp Met Asn 
    610                 615                 620                 


Asp Ile Ala Gly Tyr Ser Asn Val Gln Val Ser Gly Tyr Leu Ala Val 
625                 630                 635                 640 


Trp Val Pro Val Gly Ala Lys Ala Asp Gln Asp Ala Arg Thr Thr Ala 
                645                 650                 655     


Ser Lys Lys Lys Asn Ala Ser Gly Gln Val Tyr Glu Ser Ser Ala Ala 
            660                 665                 670         


Leu Asp Ser Gln Leu Ile Tyr Glu Gly Phe Ser Asn Phe Gln Asp Phe 
        675                 680                 685             


Ala Thr Arg Asp Asp Gln Tyr Thr Asn Lys Val Ile Ala Lys Asn Val 
    690                 695                 700                 


Asn Leu Phe Lys Glu Trp Gly Val Thr Ser Phe Glu Leu Pro Pro Gln 
705                 710                 715                 720 


Tyr Val Ser Ser Gln Asp Gly Thr Phe Leu Asp Ser Ile Ile Gln Asn 
                725                 730                 735     


Gly Tyr Ala Phe Glu Asp Arg Tyr Asp Met Ala Met Ser Lys Asn Asn 
            740                 745                 750         


Lys Tyr Gly Ser Leu Lys Asp Leu Leu Asn Ala Leu Arg Ala Leu His 
        755                 760                 765             


Ser Val Asn Ile Gln Ala Ile Ala Asp Trp Val Pro Asp Gln Ile Tyr 
    770                 775                 780                 


Asn Leu Pro Gly Lys Glu Val Val Thr Ala Thr Arg Val Asn Asn Tyr 
785                 790                 795                 800 


Gly Thr Tyr Arg Glu Gly Ala Glu Ile Lys Glu Lys Leu Tyr Val Ala 
                805                 810                 815     


Asn Ser Lys Thr Asn Glu Thr Asp Phe Gln Gly Lys Tyr Gly Gly Ala 
            820                 825                 830         


Phe Leu Asp Glu Leu Lys Ala Lys Tyr Pro Glu Ile Phe Glu Arg Val 
        835                 840                 845             


Gln Ile Ser Asn Gly Gln Lys Met Thr Thr Asp Glu Lys Ile Thr Lys 
    850                 855                 860                 


Trp Ser Ala Lys Tyr Phe Asn Gly Thr Asn Ile Leu Gly Arg Gly Ala 
865                 870                 875                 880 


Tyr Tyr Val Leu Lys Asp Trp Ala Ser Asn Asp Tyr Leu Thr Asn Arg 
                885                 890                 895     


Asn Gly Glu Ile Val Leu Pro Lys Gln Leu Val Asn Lys Asn Ser Tyr 
            900                 905                 910         


Thr Gly Phe Val Ser Asp Ala Asn Gly Thr Lys Phe Tyr Ser Thr Ser 
        915                 920                 925             


Gly Tyr Gln Ala Lys Asn Ser Phe Ile Gln Asp Glu Asn Gly Asn Trp 
    930                 935                 940                 


Tyr Tyr Phe Asp Lys Arg Gly Tyr Leu Val Thr Gly Ala His Glu Ile 
945                 950                 955                 960 


Asp Gly Lys His Val Tyr Phe Leu Lys Asn Gly Ile Gln Leu Arg Asp 
                965                 970                 975     


Ser Ile Arg Glu Asp Glu Asn Gly Asn Gln Tyr Tyr Tyr Asp Gln Thr 
            980                 985                 990         


Gly Ala Gln Val Leu Asn Arg Tyr  Tyr Thr Thr Asp Gly  Gln Asn Trp 
        995                 1000                 1005             


Arg Tyr  Phe Asp Ala Lys Gly  Val Met Ala Arg Gly  Leu Val Lys 
    1010                 1015                 1020             


Ile Gly  Asp Gly Gln Gln Phe  Phe Asp Glu Asn Gly  Tyr Gln Val 
    1025                 1030                 1035             


Lys Gly  Lys Ile Val Ser Ala  Lys Asp Gly Lys Leu  Arg Tyr Phe 
    1040                 1045                 1050             


Asp Lys  Asp Ser Gly Asn Ala  Val Ile Asn Arg Phe  Ala Gln Gly 
    1055                 1060                 1065             


Asp Asn  Pro Ser Asp Trp Tyr  Tyr Phe Gly Val Glu  Phe Ala Lys 
    1070                 1075                 1080             


Leu Thr  Gly Leu Gln Lys Ile  Gly Gln Gln Thr Leu  Tyr Phe Asp 
    1085                 1090                 1095             


Gln Asp  Gly Lys Gln Val Lys  Gly Lys Ile Val Thr  Leu Ser Asp 
    1100                 1105                 1110             


Lys Ser  Ile Arg Tyr Phe Asp  Ala Asn Ser Gly Glu  Met Ala Val 
    1115                 1120                 1125             


Gly Lys  Phe Ala Glu Gly Ala  Lys Asn Glu Trp Tyr  Tyr Phe Asp 
    1130                 1135                 1140             


Lys Thr  Gly Lys Ala Val Thr  Gly Leu Gln Lys Ile  Gly Lys Gln 
    1145                 1150                 1155             


Thr Leu  Tyr Phe Asp Gln Asp  Gly Lys Gln Val Lys  Gly Lys Val 
    1160                 1165                 1170             


Val Thr  Leu Ala Asp Lys Ser  Ile Arg Tyr Phe Asp  Ala Asp Ser 
    1175                 1180                 1185             


Gly Glu  Met Ala Val Gly Lys  Phe Ala Glu Gly Ala  Lys Asn Glu 
    1190                 1195                 1200             


Trp Tyr  Tyr Phe Asp Gln Thr  Gly Lys Ala Val Thr  Gly Leu Gln 
    1205                 1210                 1215             


Lys Ile  Asp Lys Gln Thr Leu  Tyr Phe Asp Gln Asp  Gly Lys Gln 
    1220                 1225                 1230             


Val Lys  Gly Lys Ile Val Thr  Leu Ser Asp Lys Ser  Ile Arg Tyr 
    1235                 1240                 1245             


Phe Asp  Ala Asn Ser Gly Glu  Met Ala Thr Asn Lys  Phe Val Glu 
    1250                 1255                 1260             


Gly Ser  Gln Asn Glu Trp Tyr  Tyr Phe Asp Gln Ala  Gly Lys Ala 
    1265                 1270                 1275             


Val Thr  Gly Leu Gln Gln Val  Gly Gln Gln Thr Leu  Tyr Phe Thr 
    1280                 1285                 1290             


Gln Asp  Gly Lys Gln Val Lys  Gly Lys Val Val Asp  Val Asn Gly 
    1295                 1300                 1305             


Val Ser  Arg Tyr Phe Asp Ala  Asn Ser Gly Asp Met  Ala Arg Ser 
    1310                 1315                 1320             


Lys Trp  Ile Gln Leu Glu Asp  Gly Ser Trp Met Tyr  Phe Asp Arg 
    1325                 1330                 1335             


Asp Gly  Arg Gly Gln Asn Phe  Gly Arg Asn 
    1340                 1345             


<210>  3
<211>  3729
<212>  DNA
<213>  Streptococcus sp. C150

<400>  3
atgattaacg gtaaagagta ttatgtcgaa gatgacggca cggtccgtaa gaattacgtt       60

ttggaacgta acggcggcag ccaatacttc aatgcagaga ctggtgaact cagcaatcag      120

aaagattatc gcttcgataa gaacggcggc accggtagcg cggcagatag caccactaat      180

accaatgtta ccgtgaatgg tgataagaac gcgttttacg gtaccacgga gaaagacatc      240

gagttggtgg acggttactt cactgcgaac acttggtatc gcccgaaaga aattctgaaa      300

gacggcaagg aatggacggc gagcaccgag aatgataagc gtccgttgct gacggtttgg      360

tggccaagca aggcaatcca ggcgagctat ctgaactata tgcgtgagga gggtctgggt      420

accaaccaaa ccttcacgag ctacagcagc caaacgcaaa tggatcaggc agccttagag      480

gttcaaaaac gtatcgaaga acgcattgca cgcgagggta ataccgattg gctgcgtacc      540

accatcaaga acttcgttaa aacgcagccg ggttggaaca gcacctcaga gaatctggac      600

aactctgacc atctgcaggg tggcgccctg ctgtataaca atagcaaccg cacgtcctac      660

gcgaactctg actatcgctt gctgaatcgt acccctaccc aacaagatgg cacgcgtcgc      720

tacttcaagg acaattcttc tggcggtttc gagtttttgc tggcgaatga catcgataac      780

agcaacccgg cagtgcaggc agaacaactg aattggctgc actacattat gaatattggc      840

agcctgacgg gtggtagcga agatgagaat ttcgacggtg ttcgtgttga tgctgtggac      900

aacgttaatg cggacttgct gcaaatcgca tccgactact ttaaagcaaa atacggcgtg      960

gagaaaagcg aagaagaagc gattaagcat ctgtccatct tagaggcgtg gagccacaac     1020

gatgcgtatt acaatgaaga tactaagggc gcacagctgc cgatggatga tccgctgcgc     1080

ttggcgatgg tttttagctt tctgcgtccg attggtaatc gtagcggcct ggagccgttg     1140

atcacgaact cgctgaacga ccgtagcgag agcaaaaaga ataccaagcg catggcgaac     1200

tataccttcg tgcgtgctca tgactctgag gtccagagcg ttatcggtca gattatcaag     1260

aacgaaatca atcctcagag cacgggtaac acgttcacgt tggatgaaat gaaaaaggct     1320

tttaagatct ataacgcgga catgcgcagc gcgaataaac gttacaccca atacaacatt     1380

ccgagcgcgt acgcttttat gctgaccaac aaggataccg ttccgcgtgt gtattatggt     1440

gacctgtaca cggacgatgg tcaatacatg gcacagaaat caccgtacca cgatgccatc     1500

agcaccctgc tgcaagcccg tattcgttac gctgctggcg gccaagatat gaagatgagc     1560

tatgtgggca gcggtaatac taacggctgg gacgcgtccg gtgtcctgac cagcgttcgc     1620

tatggtaaag gtgcgaacaa tgcgagcgac gcaggcaccg ccgaaacccg caatcaaggc     1680

atggccgtga ttctgagcaa ccagccggca ctgcgtctga atagcaatct gaccatcaac     1740

atgggtgccg cgcatcgtaa tcaagcatat cgcccactgc tgctgaccac gagcaatggc     1800

gtggcgagct acctgaatga cggtgatgcc aacggtattg ttaagtatac cgacgcgaac     1860

ggttatctga cgttcaaccc gggtgagatc agcggcgttc gtaatgctca ggtcgacggt     1920

tatttggcgg tttgggtccc gctgggcgca agcgagaacc aagacgtgcg tgttgccgcg     1980

agcaaaagca aaaacagcag cggtctggta tacgactcta gcgcggcact ggactcccaa     2040

gttatctatg aaggctttag caattttcag gatttcgtgc aggacccgtc ccagtatacc     2100

aacaagaaaa tcgccgagaa tgcaaatttg ttcaaatcct ggggcattac ctcgtttgaa     2160

tttgccccgc agtacgtgag ctccgacgat ggtaccttcc tggacagcgt cattcagaac     2220

ggctacgcgt tcagcgatcg ctacgatatt ggtatgagca aagacaacaa gtacggcagc     2280

ctggcagatc tgaaagcggc gcttaagtcc ctgcacgccg tcggtatctc cgcgatcgca     2340

gactgggtcc cggaccagat ttacaatctg cctggtgatg aagtggtgac cgccacccgt     2400

gtgaacaatt acggtgaaac gaaagacggc gcgatcatcg accacagcct gtacgtcgcg     2460

aaaacccgca cgtttggtaa cgattatcaa ggtaagtacg gtggcgctta cctggatgaa     2520

ctcaagcgtc tgtatccgca gtttttcgac cgtgttcaga tcagcaccgg caagcgtctg     2580

accaccgatg agaagattac gaagtggtcc gcgaaataca tgaatggtac caacattctg     2640

gaccgtggta gcgagtatgt tctgaagaac ggcctgtcgg gttactatgg cacgaacggt     2700

ggcaaagttt ccctgccgaa agtcgtcggc tctaaccaga gcacgaacaa caataaccaa     2760

aacggtgatg gcagcggccg tttcgagaaa agctggggta gcgtgtatta tcgttacaat     2820

gacggccagc gtgcgcgtaa tgctttcatt aaagacaacg atggtaacgt ttactacttt     2880

gacaacactg gccgtatggc catcggtgaa aagacgattg atggtaagca gtacttcttc     2940

ctggcgaacg gtgttcagct gcgtgacggt taccgtcaga accgtcgcgg tcaggtcttt     3000

tactacgacg agaacggtat tatgagccag acgggtaagc cgtccccgaa gccagagcca     3060

aaaccggaca acaatacgtt ttctcgcaat caattcattc agattggcaa taacgtctgg     3120

gcctattacg atggtaatgg taaaagagtg atcggtcgtc agaatatcaa tggtcaagaa     3180

ctgtttttcg ataacaacgg cgtccaagtc aagggtcgca ccgcccaagt ggacggcgtg     3240

acccgttact ttgacgctaa ttctggcgag atggcgcgta accgcttcgc agaagtggag     3300

ccgggtgtct gggcttactt caacaacgat ggtgccgcgg tgaccggtag ccagaacatt     3360

aatggccaga ccctgtattt cgaccagaat ggtcaccaag ttaaaggtgc cctggttacc     3420

gtcgatggca atctgcgcta ttacgacgcg aattcgggcg acctgtatcg caaccgcttc     3480

caagaagtca atggcagctg gtactatttt gatggtaacg gtaacgcagt caaaggcatg     3540

gtgaacatta acggtcagaa tctgctgttt gataatgatg gcaaacaagt gaaaggtcac     3600

ctggtccgcg ttaatggtgt cattcgttat tacgacccga atagcggtga gatggctgtt     3660

aatcgttggg tcgagatcag cagcggttgg tgggtgtact ttgatggcga gggtcgtggt     3720

caaatctaa                                                             3729


<210>  4
<211>  1242
<212>  PRT
<213>  Streptococcus sp. C150

<400>  4

Met Ile Asn Gly Lys Glu Tyr Tyr Val Glu Asp Asp Gly Thr Val Arg 
1               5                   10                  15      


Lys Asn Tyr Val Leu Glu Arg Asn Gly Gly Ser Gln Tyr Phe Asn Ala 
            20                  25                  30          


Glu Thr Gly Glu Leu Ser Asn Gln Lys Asp Tyr Arg Phe Asp Lys Asn 
        35                  40                  45              


Gly Gly Thr Gly Ser Ala Ala Asp Ser Thr Thr Asn Thr Asn Val Thr 
    50                  55                  60                  


Val Asn Gly Asp Lys Asn Ala Phe Tyr Gly Thr Thr Glu Lys Asp Ile 
65                  70                  75                  80  


Glu Leu Val Asp Gly Tyr Phe Thr Ala Asn Thr Trp Tyr Arg Pro Lys 
                85                  90                  95      


Glu Ile Leu Lys Asp Gly Lys Glu Trp Thr Ala Ser Thr Glu Asn Asp 
            100                 105                 110         


Lys Arg Pro Leu Leu Thr Val Trp Trp Pro Ser Lys Ala Ile Gln Ala 
        115                 120                 125             


Ser Tyr Leu Asn Tyr Met Arg Glu Glu Gly Leu Gly Thr Asn Gln Thr 
    130                 135                 140                 


Phe Thr Ser Tyr Ser Ser Gln Thr Gln Met Asp Gln Ala Ala Leu Glu 
145                 150                 155                 160 


Val Gln Lys Arg Ile Glu Glu Arg Ile Ala Arg Glu Gly Asn Thr Asp 
                165                 170                 175     


Trp Leu Arg Thr Thr Ile Lys Asn Phe Val Lys Thr Gln Pro Gly Trp 
            180                 185                 190         


Asn Ser Thr Ser Glu Asn Leu Asp Asn Ser Asp His Leu Gln Gly Gly 
        195                 200                 205             


Ala Leu Leu Tyr Asn Asn Ser Asn Arg Thr Ser Tyr Ala Asn Ser Asp 
    210                 215                 220                 


Tyr Arg Leu Leu Asn Arg Thr Pro Thr Gln Gln Asp Gly Thr Arg Arg 
225                 230                 235                 240 


Tyr Phe Lys Asp Asn Ser Ser Gly Gly Phe Glu Phe Leu Leu Ala Asn 
                245                 250                 255     


Asp Ile Asp Asn Ser Asn Pro Ala Val Gln Ala Glu Gln Leu Asn Trp 
            260                 265                 270         


Leu His Tyr Ile Met Asn Ile Gly Ser Leu Thr Gly Gly Ser Glu Asp 
        275                 280                 285             


Glu Asn Phe Asp Gly Val Arg Val Asp Ala Val Asp Asn Val Asn Ala 
    290                 295                 300                 


Asp Leu Leu Gln Ile Ala Ser Asp Tyr Phe Lys Ala Lys Tyr Gly Val 
305                 310                 315                 320 


Glu Lys Ser Glu Glu Glu Ala Ile Lys His Leu Ser Ile Leu Glu Ala 
                325                 330                 335     


Trp Ser His Asn Asp Ala Tyr Tyr Asn Glu Asp Thr Lys Gly Ala Gln 
            340                 345                 350         


Leu Pro Met Asp Asp Pro Leu Arg Leu Ala Met Val Phe Ser Phe Leu 
        355                 360                 365             


Arg Pro Ile Gly Asn Arg Ser Gly Leu Glu Pro Leu Ile Thr Asn Ser 
    370                 375                 380                 


Leu Asn Asp Arg Ser Glu Ser Lys Lys Asn Thr Lys Arg Met Ala Asn 
385                 390                 395                 400 


Tyr Thr Phe Val Arg Ala His Asp Ser Glu Val Gln Ser Val Ile Gly 
                405                 410                 415     


Gln Ile Ile Lys Asn Glu Ile Asn Pro Gln Ser Thr Gly Asn Thr Phe 
            420                 425                 430         


Thr Leu Asp Glu Met Lys Lys Ala Phe Lys Ile Tyr Asn Ala Asp Met 
        435                 440                 445             


Arg Ser Ala Asn Lys Arg Tyr Thr Gln Tyr Asn Ile Pro Ser Ala Tyr 
    450                 455                 460                 


Ala Phe Met Leu Thr Asn Lys Asp Thr Val Pro Arg Val Tyr Tyr Gly 
465                 470                 475                 480 


Asp Leu Tyr Thr Asp Asp Gly Gln Tyr Met Ala Gln Lys Ser Pro Tyr 
                485                 490                 495     


His Asp Ala Ile Ser Thr Leu Leu Gln Ala Arg Ile Arg Tyr Ala Ala 
            500                 505                 510         


Gly Gly Gln Asp Met Lys Met Ser Tyr Val Gly Ser Gly Asn Thr Asn 
        515                 520                 525             


Gly Trp Asp Ala Ser Gly Val Leu Thr Ser Val Arg Tyr Gly Lys Gly 
    530                 535                 540                 


Ala Asn Asn Ala Ser Asp Ala Gly Thr Ala Glu Thr Arg Asn Gln Gly 
545                 550                 555                 560 


Met Ala Val Ile Leu Ser Asn Gln Pro Ala Leu Arg Leu Asn Ser Asn 
                565                 570                 575     


Leu Thr Ile Asn Met Gly Ala Ala His Arg Asn Gln Ala Tyr Arg Pro 
            580                 585                 590         


Leu Leu Leu Thr Thr Ser Asn Gly Val Ala Ser Tyr Leu Asn Asp Gly 
        595                 600                 605             


Asp Ala Asn Gly Ile Val Lys Tyr Thr Asp Ala Asn Gly Tyr Leu Thr 
    610                 615                 620                 


Phe Asn Pro Gly Glu Ile Ser Gly Val Arg Asn Ala Gln Val Asp Gly 
625                 630                 635                 640 


Tyr Leu Ala Val Trp Val Pro Leu Gly Ala Ser Glu Asn Gln Asp Val 
                645                 650                 655     


Arg Val Ala Ala Ser Lys Ser Lys Asn Ser Ser Gly Leu Val Tyr Asp 
            660                 665                 670         


Ser Ser Ala Ala Leu Asp Ser Gln Val Ile Tyr Glu Gly Phe Ser Asn 
        675                 680                 685             


Phe Gln Asp Phe Val Gln Asp Pro Ser Gln Tyr Thr Asn Lys Lys Ile 
    690                 695                 700                 


Ala Glu Asn Ala Asn Leu Phe Lys Ser Trp Gly Ile Thr Ser Phe Glu 
705                 710                 715                 720 


Phe Ala Pro Gln Tyr Val Ser Ser Asp Asp Gly Thr Phe Leu Asp Ser 
                725                 730                 735     


Val Ile Gln Asn Gly Tyr Ala Phe Ser Asp Arg Tyr Asp Ile Gly Met 
            740                 745                 750         


Ser Lys Asp Asn Lys Tyr Gly Ser Leu Ala Asp Leu Lys Ala Ala Leu 
        755                 760                 765             


Lys Ser Leu His Ala Val Gly Ile Ser Ala Ile Ala Asp Trp Val Pro 
    770                 775                 780                 


Asp Gln Ile Tyr Asn Leu Pro Gly Asp Glu Val Val Thr Ala Thr Arg 
785                 790                 795                 800 


Val Asn Asn Tyr Gly Glu Thr Lys Asp Gly Ala Ile Ile Asp His Ser 
                805                 810                 815     


Leu Tyr Val Ala Lys Thr Arg Thr Phe Gly Asn Asp Tyr Gln Gly Lys 
            820                 825                 830         


Tyr Gly Gly Ala Tyr Leu Asp Glu Leu Lys Arg Leu Tyr Pro Gln Phe 
        835                 840                 845             


Phe Asp Arg Val Gln Ile Ser Thr Gly Lys Arg Leu Thr Thr Asp Glu 
    850                 855                 860                 


Lys Ile Thr Lys Trp Ser Ala Lys Tyr Met Asn Gly Thr Asn Ile Leu 
865                 870                 875                 880 


Asp Arg Gly Ser Glu Tyr Val Leu Lys Asn Gly Leu Ser Gly Tyr Tyr 
                885                 890                 895     


Gly Thr Asn Gly Gly Lys Val Ser Leu Pro Lys Val Val Gly Ser Asn 
            900                 905                 910         


Gln Ser Thr Asn Asn Asn Asn Gln Asn Gly Asp Gly Ser Gly Arg Phe 
        915                 920                 925             


Glu Lys Ser Trp Gly Ser Val Tyr Tyr Arg Tyr Asn Asp Gly Gln Arg 
    930                 935                 940                 


Ala Arg Asn Ala Phe Ile Lys Asp Asn Asp Gly Asn Val Tyr Tyr Phe 
945                 950                 955                 960 


Asp Asn Thr Gly Arg Met Ala Ile Gly Glu Lys Thr Ile Asp Gly Lys 
                965                 970                 975     


Gln Tyr Phe Phe Leu Ala Asn Gly Val Gln Leu Arg Asp Gly Tyr Arg 
            980                 985                 990         


Gln Asn Arg Arg Gly Gln Val Phe  Tyr Tyr Asp Glu Asn  Gly Ile Met 
        995                 1000                 1005             


Ser Gln  Thr Gly Lys Pro Ser  Pro Lys Pro Glu Pro  Lys Pro Asp 
    1010                 1015                 1020             


Asn Asn  Thr Phe Ser Arg Asn  Gln Phe Ile Gln Ile  Gly Asn Asn 
    1025                 1030                 1035             


Val Trp  Ala Tyr Tyr Asp Gly  Asn Gly Lys Arg Val  Ile Gly Arg 
    1040                 1045                 1050             


Gln Asn  Ile Asn Gly Gln Glu  Leu Phe Phe Asp Asn  Asn Gly Val 
    1055                 1060                 1065             


Gln Val  Lys Gly Arg Thr Ala  Gln Val Asp Gly Val  Thr Arg Tyr 
    1070                 1075                 1080             


Phe Asp  Ala Asn Ser Gly Glu  Met Ala Arg Asn Arg  Phe Ala Glu 
    1085                 1090                 1095             


Val Glu  Pro Gly Val Trp Ala  Tyr Phe Asn Asn Asp  Gly Ala Ala 
    1100                 1105                 1110             


Val Thr  Gly Ser Gln Asn Ile  Asn Gly Gln Thr Leu  Tyr Phe Asp 
    1115                 1120                 1125             


Gln Asn  Gly His Gln Val Lys  Gly Ala Leu Val Thr  Val Asp Gly 
    1130                 1135                 1140             


Asn Leu  Arg Tyr Tyr Asp Ala  Asn Ser Gly Asp Leu  Tyr Arg Asn 
    1145                 1150                 1155             


Arg Phe  Gln Glu Val Asn Gly  Ser Trp Tyr Tyr Phe  Asp Gly Asn 
    1160                 1165                 1170             


Gly Asn  Ala Val Lys Gly Met  Val Asn Ile Asn Gly  Gln Asn Leu 
    1175                 1180                 1185             


Leu Phe  Asp Asn Asp Gly Lys  Gln Val Lys Gly His  Leu Val Arg 
    1190                 1195                 1200             


Val Asn  Gly Val Ile Arg Tyr  Tyr Asp Pro Asn Ser  Gly Glu Met 
    1205                 1210                 1215             


Ala Val  Asn Arg Trp Val Glu  Ile Ser Ser Gly Trp  Trp Val Tyr 
    1220                 1225                 1230             


Phe Asp  Gly Glu Gly Arg Gly  Gln Ile 
    1235                 1240         


<210>  5
<211>  3942
<212>  DNA
<213>  Streptococcus mutans

<400>  5
atgattgacg gcaaatacta ctactatgac aacaacggca aagtacgcac caatttcacg       60

ttgatcgcgg acggtaaaat cctgcatttt gatgaaactg gcgcgtacac cgacactagc      120

attgataccg tgaacaagga tattgtcacg acgcgtagca acctgtataa gaaatacaat      180

caagtgtatg atcgcagcgc gcagagcttc gagcatgttg atcactacct gacggcggaa      240

tcttggtacc gtccgaaata cattctgaaa gatggcaaga cctggaccca gagcaccgag      300

aaggacttcc gtcctctgct gatgacctgg tggccgagcc aggaaacgca gcgccagtat      360

gtcaacttca tgaacgccca gttgggtatc aacaaaacgt acgacgacac cagcaatcag      420

ctgcaattga acatcgctgc tgcaacgatc caagcaaaga tcgaagccaa aatcacgacg      480

ctgaagaaca ccgattggct gcgtcaaacg atcagcgcgt tcgtcaaaac ccaaagcgct      540

tggaatagcg acagcgaaaa gccgtttgat gaccatctgc aaaacggtgc ggttctgtat      600

gataacgaag gtaaattgac gccgtatgcc aatagcaact atcgtattct gaaccgcacg      660

ccgaccaacc agaccggtaa gaaggacccg cgttataccg ccgacaacac gatcggcggc      720

tacgagtttc tgctggccaa cgacgtggat aatagcaacc cggtggttca ggccgagcag      780

ctgaactggc tgcacttcct gatgaacttt ggtaatatct acgcaaacga ccctgacgct      840

aacttcgact ccatccgcgt tgacgctgtc gataatgtgg acgccgatct gttacagatc      900

gcgggtgact atctgaaagc ggcaaagggc atccataaga atgacaaagc ggcgaacgac      960

cacctgtcca ttctggaagc gtggagcgac aatgacactc cgtatctgca tgatgatggc     1020

gacaacatga ttaacatgga taacaaactg cgcctgagcc tgctgttctc cctggcgaaa     1080

ccgctgaatc agcgtagcgg tatgaacccg ttgattacga acagcctggt caaccgtact     1140

gatgataatg ccgaaacggc ggcagtgcca agctactctt ttatccgtgc ccacgatagc     1200

gaggtccagg atttgattcg tgatatcatt aaggctgaga ttaacccgaa cgtcgtcggt     1260

tacagcttca cgatggaaga gattaagaag gcatttgaga tctacaataa ggacctgttg     1320

gccacggaga agaagtatac ccactataac accgcattga gctacgcgtt gctgctgacg     1380

aacaagagca gcgtgccgcg tgtctactat ggtgatatgt ttacggacga tggtcaatac     1440

atggcccaca agaccattaa ctacgaggca atcgaaaccc tgctgaaagc acgtatcaag     1500

tacgtgtccg gtggtcaggc tatgcgcaac cagcaagtgg gtaattcgga gatcatcacc     1560

agcgtgcgtt acggtaaagg tgcgctgaag gcgatggata cgggtgaccg cactacccgt     1620

acctctggtg tggcggtcat tgagggcaac aacccgagct tgcgcctgaa ggcttctgat     1680

cgtgtggttg tgaatatggg tgcggcccac aaaaatcaag cctatcgccc gctgctgttg     1740

acgaccgata acggcattaa ggcctatcac agcgaccaag aagcggcagg cctggtgcgt     1800

tacaccaacg accgtggcga actgatcttt accgcagccg acattaaggg ctacgcaaat     1860

ccgcaagtta gcggctacct gggcgtctgg gtccctgttg gcgcagcagc tgatcaggac     1920

gttcgtgttg cggcgagcac cgcgccaagc acggacggca agagcgttca ccagaacgcg     1980

gctctggaca gccgtgtgat gttcgagggt ttctcgaact tccaggcatt tgctaccaag     2040

aaagaagagt ataccaatgt ggtcatcgct aagaatgtgg ataagttcgc ggagtggggt     2100

gtcaccgatt tcgagatggc tccgcaatac gtttctagca ccgacggtag ctttttggat     2160

agcgtgattc aaaacggtta tgcttttacc gaccgttacg acctgggcat cagcaagccg     2220

aacaaatatg gcaccgcgga cgatctggtt aaagcgatta aggcattgca cagcaaaggc     2280

atcaaagtta tggcggattg ggttccggac cagatgtatg ccctgccgga aaaagaggtt     2340

gtgacggcaa cccgtgttga caaatacggt acgccggtag ctggcagcca gatcaaaaac     2400

acgctgtacg tggtcgatgg taaatctagc ggtaaggacc agcaggcgaa gtacggtggt     2460

gccttcctgg aagagctgca agcgaagtat ccggaactgt tcgcgcgcaa acagattagc     2520

accggtgttc cgatggaccc gagcgtcaag attaagcaat ggagcgcaaa atacttcaac     2580

ggcacgaata tcctgggtcg tggtgctggt tacgtgctga aagatcaggc aaccaacacc     2640

tactttaaca tcagcgacaa taaagagatc aatttcctgc caaagacgtt gctgaaccag     2700

gattctcaag ttggctttag ctacgacggt aagggctatg tgtactacag cacctcgggc     2760

taccaggcta aaaacacgtt catcagcgag ggtgacaagt ggtattactt cgacaataac     2820

ggttatatgg ttaccggcgc acagagcatt aatggtgtga actattactt cctgccgaat     2880

ggtttacagc tgcgtgatgc gattctgaaa aatgaggacg gtacgtacgc gtattatggc     2940

aatgatggtc gccgctacga gaatggctat tatcagttta tgagcggtgt ttggcgccat     3000

ttcaataatg gcgagatgtc cgttggtctg accgtcattg acggtcaagt tcaatacttt     3060

gacgagatgg gttaccaggc gaaaggcaaa ttcgttacca ccgcggatgg taagatccgt     3120

tacttcgata agcagagcgg caatatgtat cgtaatcgtt tcattgagaa cgaagagggc     3180

aaatggctgt acctgggtga ggacggcgcg gcagtcaccg gtagccagac gatcaatggt     3240

cagcacctgt attttcgtgc taacggcgtt caggttaagg gtgagttcgt gaccgatcgt     3300

catggccgca tctcttatta cgacggcaac agcggtgatc agatccgcaa ccgtttcgtc     3360

cgcaatgcgc aaggccagtg gttttacttt gacaacaatg gctatgcagt aactggtgct     3420

cgtacgatca acggccagca cctgtatttc cgcgcgaacg gtgttcaggt aaaaggtgag     3480

tttgttacgg accgccacgg ccgcattagc tattatgatg gtaatagcgg tgaccaaatt     3540

cgcaatcgtt tcgtgcgtaa tgcacagggt cagtggttct acttcgacaa taatggttat     3600

gcagtcacgg gtgcacgtac cattaacggc caacacctgt actttcgcgc caatggtgtg     3660

caagtgaaag gcgaatttgt tactgatcgt tatggtcgta tcagctacta tgatggcaat     3720

tctggcgacc aaattcgcaa tcgctttgtt cgtaacgccc aaggtcaatg gttctatttc     3780

gacaacaacg gttacgcggt gaccggtgcc cgcacgatta atggtcaaca cttgtacttc     3840

cgtgccaacg gtgtccaggt gaagggtgaa tttgtgaccg accgctatgg tcgcatttct     3900

tactacgacg caaattccgg tgaacgcgtc cgtatcaatt aa                        3942


<210>  6
<211>  1313
<212>  PRT
<213>  Streptococcus mutans

<400>  6

Met Ile Asp Gly Lys Tyr Tyr Tyr Tyr Asp Asn Asn Gly Lys Val Arg 
1               5                   10                  15      


Thr Asn Phe Thr Leu Ile Ala Asp Gly Lys Ile Leu His Phe Asp Glu 
            20                  25                  30          


Thr Gly Ala Tyr Thr Asp Thr Ser Ile Asp Thr Val Asn Lys Asp Ile 
        35                  40                  45              


Val Thr Thr Arg Ser Asn Leu Tyr Lys Lys Tyr Asn Gln Val Tyr Asp 
    50                  55                  60                  


Arg Ser Ala Gln Ser Phe Glu His Val Asp His Tyr Leu Thr Ala Glu 
65                  70                  75                  80  


Ser Trp Tyr Arg Pro Lys Tyr Ile Leu Lys Asp Gly Lys Thr Trp Thr 
                85                  90                  95      


Gln Ser Thr Glu Lys Asp Phe Arg Pro Leu Leu Met Thr Trp Trp Pro 
            100                 105                 110         


Ser Gln Glu Thr Gln Arg Gln Tyr Val Asn Phe Met Asn Ala Gln Leu 
        115                 120                 125             


Gly Ile Asn Lys Thr Tyr Asp Asp Thr Ser Asn Gln Leu Gln Leu Asn 
    130                 135                 140                 


Ile Ala Ala Ala Thr Ile Gln Ala Lys Ile Glu Ala Lys Ile Thr Thr 
145                 150                 155                 160 


Leu Lys Asn Thr Asp Trp Leu Arg Gln Thr Ile Ser Ala Phe Val Lys 
                165                 170                 175     


Thr Gln Ser Ala Trp Asn Ser Asp Ser Glu Lys Pro Phe Asp Asp His 
            180                 185                 190         


Leu Gln Asn Gly Ala Val Leu Tyr Asp Asn Glu Gly Lys Leu Thr Pro 
        195                 200                 205             


Tyr Ala Asn Ser Asn Tyr Arg Ile Leu Asn Arg Thr Pro Thr Asn Gln 
    210                 215                 220                 


Thr Gly Lys Lys Asp Pro Arg Tyr Thr Ala Asp Asn Thr Ile Gly Gly 
225                 230                 235                 240 


Tyr Glu Phe Leu Leu Ala Asn Asp Val Asp Asn Ser Asn Pro Val Val 
                245                 250                 255     


Gln Ala Glu Gln Leu Asn Trp Leu His Phe Leu Met Asn Phe Gly Asn 
            260                 265                 270         


Ile Tyr Ala Asn Asp Pro Asp Ala Asn Phe Asp Ser Ile Arg Val Asp 
        275                 280                 285             


Ala Val Asp Asn Val Asp Ala Asp Leu Leu Gln Ile Ala Gly Asp Tyr 
    290                 295                 300                 


Leu Lys Ala Ala Lys Gly Ile His Lys Asn Asp Lys Ala Ala Asn Asp 
305                 310                 315                 320 


His Leu Ser Ile Leu Glu Ala Trp Ser Asp Asn Asp Thr Pro Tyr Leu 
                325                 330                 335     


His Asp Asp Gly Asp Asn Met Ile Asn Met Asp Asn Lys Leu Arg Leu 
            340                 345                 350         


Ser Leu Leu Phe Ser Leu Ala Lys Pro Leu Asn Gln Arg Ser Gly Met 
        355                 360                 365             


Asn Pro Leu Ile Thr Asn Ser Leu Val Asn Arg Thr Asp Asp Asn Ala 
    370                 375                 380                 


Glu Thr Ala Ala Val Pro Ser Tyr Ser Phe Ile Arg Ala His Asp Ser 
385                 390                 395                 400 


Glu Val Gln Asp Leu Ile Arg Asp Ile Ile Lys Ala Glu Ile Asn Pro 
                405                 410                 415     


Asn Val Val Gly Tyr Ser Phe Thr Met Glu Glu Ile Lys Lys Ala Phe 
            420                 425                 430         


Glu Ile Tyr Asn Lys Asp Leu Leu Ala Thr Glu Lys Lys Tyr Thr His 
        435                 440                 445             


Tyr Asn Thr Ala Leu Ser Tyr Ala Leu Leu Leu Thr Asn Lys Ser Ser 
    450                 455                 460                 


Val Pro Arg Val Tyr Tyr Gly Asp Met Phe Thr Asp Asp Gly Gln Tyr 
465                 470                 475                 480 


Met Ala His Lys Thr Ile Asn Tyr Glu Ala Ile Glu Thr Leu Leu Lys 
                485                 490                 495     


Ala Arg Ile Lys Tyr Val Ser Gly Gly Gln Ala Met Arg Asn Gln Gln 
            500                 505                 510         


Val Gly Asn Ser Glu Ile Ile Thr Ser Val Arg Tyr Gly Lys Gly Ala 
        515                 520                 525             


Leu Lys Ala Met Asp Thr Gly Asp Arg Thr Thr Arg Thr Ser Gly Val 
    530                 535                 540                 


Ala Val Ile Glu Gly Asn Asn Pro Ser Leu Arg Leu Lys Ala Ser Asp 
545                 550                 555                 560 


Arg Val Val Val Asn Met Gly Ala Ala His Lys Asn Gln Ala Tyr Arg 
                565                 570                 575     


Pro Leu Leu Leu Thr Thr Asp Asn Gly Ile Lys Ala Tyr His Ser Asp 
            580                 585                 590         


Gln Glu Ala Ala Gly Leu Val Arg Tyr Thr Asn Asp Arg Gly Glu Leu 
        595                 600                 605             


Ile Phe Thr Ala Ala Asp Ile Lys Gly Tyr Ala Asn Pro Gln Val Ser 
    610                 615                 620                 


Gly Tyr Leu Gly Val Trp Val Pro Val Gly Ala Ala Ala Asp Gln Asp 
625                 630                 635                 640 


Val Arg Val Ala Ala Ser Thr Ala Pro Ser Thr Asp Gly Lys Ser Val 
                645                 650                 655     


His Gln Asn Ala Ala Leu Asp Ser Arg Val Met Phe Glu Gly Phe Ser 
            660                 665                 670         


Asn Phe Gln Ala Phe Ala Thr Lys Lys Glu Glu Tyr Thr Asn Val Val 
        675                 680                 685             


Ile Ala Lys Asn Val Asp Lys Phe Ala Glu Trp Gly Val Thr Asp Phe 
    690                 695                 700                 


Glu Met Ala Pro Gln Tyr Val Ser Ser Thr Asp Gly Ser Phe Leu Asp 
705                 710                 715                 720 


Ser Val Ile Gln Asn Gly Tyr Ala Phe Thr Asp Arg Tyr Asp Leu Gly 
                725                 730                 735     


Ile Ser Lys Pro Asn Lys Tyr Gly Thr Ala Asp Asp Leu Val Lys Ala 
            740                 745                 750         


Ile Lys Ala Leu His Ser Lys Gly Ile Lys Val Met Ala Asp Trp Val 
        755                 760                 765             


Pro Asp Gln Met Tyr Ala Leu Pro Glu Lys Glu Val Val Thr Ala Thr 
    770                 775                 780                 


Arg Val Asp Lys Tyr Gly Thr Pro Val Ala Gly Ser Gln Ile Lys Asn 
785                 790                 795                 800 


Thr Leu Tyr Val Val Asp Gly Lys Ser Ser Gly Lys Asp Gln Gln Ala 
                805                 810                 815     


Lys Tyr Gly Gly Ala Phe Leu Glu Glu Leu Gln Ala Lys Tyr Pro Glu 
            820                 825                 830         


Leu Phe Ala Arg Lys Gln Ile Ser Thr Gly Val Pro Met Asp Pro Ser 
        835                 840                 845             


Val Lys Ile Lys Gln Trp Ser Ala Lys Tyr Phe Asn Gly Thr Asn Ile 
    850                 855                 860                 


Leu Gly Arg Gly Ala Gly Tyr Val Leu Lys Asp Gln Ala Thr Asn Thr 
865                 870                 875                 880 


Tyr Phe Asn Ile Ser Asp Asn Lys Glu Ile Asn Phe Leu Pro Lys Thr 
                885                 890                 895     


Leu Leu Asn Gln Asp Ser Gln Val Gly Phe Ser Tyr Asp Gly Lys Gly 
            900                 905                 910         


Tyr Val Tyr Tyr Ser Thr Ser Gly Tyr Gln Ala Lys Asn Thr Phe Ile 
        915                 920                 925             


Ser Glu Gly Asp Lys Trp Tyr Tyr Phe Asp Asn Asn Gly Tyr Met Val 
    930                 935                 940                 


Thr Gly Ala Gln Ser Ile Asn Gly Val Asn Tyr Tyr Phe Leu Pro Asn 
945                 950                 955                 960 


Gly Leu Gln Leu Arg Asp Ala Ile Leu Lys Asn Glu Asp Gly Thr Tyr 
                965                 970                 975     


Ala Tyr Tyr Gly Asn Asp Gly Arg Arg Tyr Glu Asn Gly Tyr Tyr Gln 
            980                 985                 990         


Phe Met Ser Gly Val Trp Arg His  Phe Asn Asn Gly Glu  Met Ser Val 
        995                 1000                 1005             


Gly Leu  Thr Val Ile Asp Gly  Gln Val Gln Tyr Phe  Asp Glu Met 
    1010                 1015                 1020             


Gly Tyr  Gln Ala Lys Gly Lys  Phe Val Thr Thr Ala  Asp Gly Lys 
    1025                 1030                 1035             


Ile Arg  Tyr Phe Asp Lys Gln  Ser Gly Asn Met Tyr  Arg Asn Arg 
    1040                 1045                 1050             


Phe Ile  Glu Asn Glu Glu Gly  Lys Trp Leu Tyr Leu  Gly Glu Asp 
    1055                 1060                 1065             


Gly Ala  Ala Val Thr Gly Ser  Gln Thr Ile Asn Gly  Gln His Leu 
    1070                 1075                 1080             


Tyr Phe  Arg Ala Asn Gly Val  Gln Val Lys Gly Glu  Phe Val Thr 
    1085                 1090                 1095             


Asp Arg  His Gly Arg Ile Ser  Tyr Tyr Asp Gly Asn  Ser Gly Asp 
    1100                 1105                 1110             


Gln Ile  Arg Asn Arg Phe Val  Arg Asn Ala Gln Gly  Gln Trp Phe 
    1115                 1120                 1125             


Tyr Phe  Asp Asn Asn Gly Tyr  Ala Val Thr Gly Ala  Arg Thr Ile 
    1130                 1135                 1140             


Asn Gly  Gln His Leu Tyr Phe  Arg Ala Asn Gly Val  Gln Val Lys 
    1145                 1150                 1155             


Gly Glu  Phe Val Thr Asp Arg  His Gly Arg Ile Ser  Tyr Tyr Asp 
    1160                 1165                 1170             


Gly Asn  Ser Gly Asp Gln Ile  Arg Asn Arg Phe Val  Arg Asn Ala 
    1175                 1180                 1185             


Gln Gly  Gln Trp Phe Tyr Phe  Asp Asn Asn Gly Tyr  Ala Val Thr 
    1190                 1195                 1200             


Gly Ala  Arg Thr Ile Asn Gly  Gln His Leu Tyr Phe  Arg Ala Asn 
    1205                 1210                 1215             


Gly Val  Gln Val Lys Gly Glu  Phe Val Thr Asp Arg  Tyr Gly Arg 
    1220                 1225                 1230             


Ile Ser  Tyr Tyr Asp Gly Asn  Ser Gly Asp Gln Ile  Arg Asn Arg 
    1235                 1240                 1245             


Phe Val  Arg Asn Ala Gln Gly  Gln Trp Phe Tyr Phe  Asp Asn Asn 
    1250                 1255                 1260             


Gly Tyr  Ala Val Thr Gly Ala  Arg Thr Ile Asn Gly  Gln His Leu 
    1265                 1270                 1275             


Tyr Phe  Arg Ala Asn Gly Val  Gln Val Lys Gly Glu  Phe Val Thr 
    1280                 1285                 1290             


Asp Arg  Tyr Gly Arg Ile Ser  Tyr Tyr Asp Ala Asn  Ser Gly Glu 
    1295                 1300                 1305             


Arg Val  Arg Ile Asn 
    1310             


<210>  7
<211>  4047
<212>  DNA
<213>  Streptococcus sanguinis

<400>  7
atgattgatg gtaaaaagta ttacgtacag gacgacggca cggttaagaa gaatttcgcg       60

gttgagctga atggcaagat cctgtacttc gatgcagaga ctggtgcgtt gattgacagc      120

gcggagtatc aattccaaca aggcaccagc agcctgaata atgagttcac tcaaaagaac      180

gccttttacg gtacgaccga taaggatgtg gaaaccattg atggttactt gaccgccgat      240

tcctggtatc gtccgaagtt cattctgaaa gatggcaaaa cctggacggc gagcacggaa      300

attgacttgc gtccgttgtt gatggcgtgg tggccggaca aacagaccca ggttagctac      360

ctgaattaca tgaaccagca aggcttgggt gcaggcgcct tcgaaaacaa agtagagcag      420

gcaattctga ccggtgcgtc ccaacaggta caacgtaaaa tcgaagaacg catcggtaaa      480

gagggtgata ccaagtggct gcgtaccctg atgggtgcat ttgtaaagac ccagccgaac      540

tggaacatta agaccgagtc cgaaaccact ggcacgaata aagatcatct gcaaggtggc      600

gcactgctgt atagcaattc cgacaagacg agccatgcca actctaagta ccgtatcctg      660

aaccgcaccc cgaccaacca aacgggcacg ccgaaatact ttattgacaa gagcaatggt      720

ggttatgaat ttctgctggc gaatgacttt gacaatagca atccggcagt gcaagcggaa      780

cagctgaact ggttgcactt tatgatgaat tttggctcca tcgttgcaaa tgatccgacg      840

gccaacttcg acggcgtccg cgttgacgct gtggataacg tgaatgcgga tctgttgcaa      900

attgcgagcg actatttcaa gagccgctat aaagtcggcg aaagcgaaga agaggccatt      960

aagcacctgt ccatcctgga agcgtggagc gacaacgacc cggactacaa caaggatact     1020

aaaggtgccc aactgccgat cgacaacaaa ctgcgtctga gcctgctgta ctccttcatg     1080

cgtaagctga gcatccgtag cggcgtcgag ccgaccatca ccaactctct gaatgatcgc     1140

agcacggaga agaagaatgg tgagcgtatg gcaaactata tcttcgttcg tgcacatgat     1200

agcgaggtgc aaacggtcat cgccgacatt atccgtgaga acatcaatcc gaataccgac     1260

ggcctgacgt tcacgatgga tgaactgaag caggccttta aaatttacaa tgaggatatg     1320

cgtaaagccg acaaaaagta cacgcagttc aatatcccga ccgcgcacgc gctgatgctg     1380

agcaacaaag attctatcac ccgcgtttac tacggtgacc tgtatacgga tgacggtcag     1440

tatatggaaa agaaaagccc gtatcacgac gccattgacg ctctgctgcg tgcgcgtatc     1500

aaatatgttg cgggtggtca ggacatgaag gtgacctata tgggcgtgcc gcgtgaggca     1560

gataaatgga gctataacgg catcctgacc agcgttcgtt atggtacggg tgccaacgag     1620

gcaaccgacg agggtacggc agaaacccgt acccagggca tggccgtcat tgccagcaac     1680

aatccgaacc tgaaactgaa cgagtgggac aagttgcagg tcaacatggg tgcagctcac     1740

aaaaaccaat actatcgtcc ggtgctgctg accaccaagg acggcatctc gcgctacctg     1800

accgacgaag aagtcccgca gagcctgtgg aaaaagaccg atgcgaacgg catcttgacg     1860

tttgacatga atgatattgc gggttacagc aacgtccaag tgagcggtta tctggccgtc     1920

tgggttcctg tgggtgcgaa ggcggaccag gacgctcgtg ttacggcatc taagaagaaa     1980

aatgcctctg gccaagttta cgaaagcagc gcagccctgg actcccagct gatctatgag     2040

ggcttcagca attttcagga ctttgccacc cgtgacgacc agtacactaa caaggttatc     2100

gcgaaaaacg tcaatctgtt taaagagtgg ggcgtcacca gcttcgaatt gccgccacag     2160

tatgtgagca gccaagacgg tacgttcctg gatagcatca tccagaatgg ttatgcattc     2220

gaagatcgct atgatatggc gatgagcaaa aacaataagt acggtagctt gaacgacctg     2280

ttgaacgcct tgcgtgcact gcatagcgtg aatatccaag cgattgcgga ttgggtgccg     2340

gaccagattt acaatctgcc gggtaaagaa gttgtcactg caacccgtgt taacaattat     2400

ggcacgtatc gtgagggtag cgagattaaa gagaacctgt acgttgctaa caccaaaacc     2460

aatggtacgg actaccaagg taagtatggt ggtgcgttct tggacgagct gaaagccaaa     2520

taccctgaga tttttgagcg cgtccaaatc agcaacggcc agaagatgac caccgacgag     2580

aagattacga aatggtccgc caaacacttt aacggcacga acattctggg tcgtggtgcg     2640

tattatgtgc tgaaagactg ggcgagcaac gagtacctga ataacaaaaa tggcgagatg     2700

gttctgccga agcagctggt taataaaaat gcatataccg gcttcgtcag cgacgcgagc     2760

ggcaccaaat actattctac cagcggctat caggctcgta atagctttat tcaagatgaa     2820

aatggtaatt ggtactactt caataaccgt ggttatttgg tgacgggtgc acaggaaatc     2880

gacggtaagc aactgtattt cctgaaaaac ggcattcagc tgcgtgattc tctgcgtgag     2940

gacgaaaacg gcaaccagta ttactatgat aagacgggtg cgcaagttct gaatcgttat     3000

tacactacgg acggccaaaa ttggcgctac ttcgacgtta aaggcgtcat ggcccgtggt     3060

ctggtcacga tgggtggtaa ccaacaattc tttgaccaaa acggttacca ggttaaaggc     3120

aaaattgcgc gtgcaaaaga cggtaaactg cgttacttcg ataaagacag cggtaatgcg     3180

gcagctaacc gtttcgccca aggcgataac cctagcgact ggtactattt cggtgcagat     3240

ggtgttgcgg ttacgggcct gcaaaaggtt ggtcagcaaa ctctgtactt tgatcaggac     3300

ggcaagcagg tgaaaggtaa agttgttacc ttggcggaca aaagcattcg ttatttcgat     3360

gcaaacagcg gcgagatggc ggtgaacaag tttgtggaag gtgctaagaa cgtgtggtac     3420

tacttcgatc aagcaggcaa agcggtgacc ggcctgcaaa ccatcaataa acaagtgctg     3480

tatttcgacc aggatggtaa acaagtcaaa ggtaaggtgg tcacgctggc tgataagtct     3540

atccgctact tcgacgcgaa cagcggtgag atggcagtgg gcaaattcgc cgaaggcgca     3600

aagaatgagt ggtattactt tgaccaggcg ggcaaggctg ttaccggtct gcaaaagatc     3660

ggccaacaga cgctgtattt cgaccagaac ggtaaacagg ttaagggtaa agtggtcacc     3720

ctggcggata agagcatccg ctatttcgac gctaactctg gcgaaatggc aagcaataag     3780

ttcgttgagg gtgccaaaaa tgaatggtac tatttcgatc aggctggcaa ggcagtgacg     3840

ggtctgcaac aaattggcca gcagaccctg tattttgacc agaatggcaa acaggtgaag     3900

ggtaagattg tgtatgttaa tggtgcgaat cgctactttg atgccaatag cggtgaaatg     3960

gcgcgtaaca agtggattca gctggaagat ggcagctgga tgtattttga ccgcaatggt     4020

cgtggtcgtc gtttcggttg gaactaa                                         4047


<210>  8
<211>  1348
<212>  PRT
<213>  Streptococcus sanguinis

<400>  8

Met Ile Asp Gly Lys Lys Tyr Tyr Val Gln Asp Asp Gly Thr Val Lys 
1               5                   10                  15      


Lys Asn Phe Ala Val Glu Leu Asn Gly Lys Ile Leu Tyr Phe Asp Ala 
            20                  25                  30          


Glu Thr Gly Ala Leu Ile Asp Ser Ala Glu Tyr Gln Phe Gln Gln Gly 
        35                  40                  45              


Thr Ser Ser Leu Asn Asn Glu Phe Thr Gln Lys Asn Ala Phe Tyr Gly 
    50                  55                  60                  


Thr Thr Asp Lys Asp Val Glu Thr Ile Asp Gly Tyr Leu Thr Ala Asp 
65                  70                  75                  80  


Ser Trp Tyr Arg Pro Lys Phe Ile Leu Lys Asp Gly Lys Thr Trp Thr 
                85                  90                  95      


Ala Ser Thr Glu Ile Asp Leu Arg Pro Leu Leu Met Ala Trp Trp Pro 
            100                 105                 110         


Asp Lys Gln Thr Gln Val Ser Tyr Leu Asn Tyr Met Asn Gln Gln Gly 
        115                 120                 125             


Leu Gly Ala Gly Ala Phe Glu Asn Lys Val Glu Gln Ala Ile Leu Thr 
    130                 135                 140                 


Gly Ala Ser Gln Gln Val Gln Arg Lys Ile Glu Glu Arg Ile Gly Lys 
145                 150                 155                 160 


Glu Gly Asp Thr Lys Trp Leu Arg Thr Leu Met Gly Ala Phe Val Lys 
                165                 170                 175     


Thr Gln Pro Asn Trp Asn Ile Lys Thr Glu Ser Glu Thr Thr Gly Thr 
            180                 185                 190         


Asn Lys Asp His Leu Gln Gly Gly Ala Leu Leu Tyr Ser Asn Ser Asp 
        195                 200                 205             


Lys Thr Ser His Ala Asn Ser Lys Tyr Arg Ile Leu Asn Arg Thr Pro 
    210                 215                 220                 


Thr Asn Gln Thr Gly Thr Pro Lys Tyr Phe Ile Asp Lys Ser Asn Gly 
225                 230                 235                 240 


Gly Tyr Glu Phe Leu Leu Ala Asn Asp Phe Asp Asn Ser Asn Pro Ala 
                245                 250                 255     


Val Gln Ala Glu Gln Leu Asn Trp Leu His Phe Met Met Asn Phe Gly 
            260                 265                 270         


Ser Ile Val Ala Asn Asp Pro Thr Ala Asn Phe Asp Gly Val Arg Val 
        275                 280                 285             


Asp Ala Val Asp Asn Val Asn Ala Asp Leu Leu Gln Ile Ala Ser Asp 
    290                 295                 300                 


Tyr Phe Lys Ser Arg Tyr Lys Val Gly Glu Ser Glu Glu Glu Ala Ile 
305                 310                 315                 320 


Lys His Leu Ser Ile Leu Glu Ala Trp Ser Asp Asn Asp Pro Asp Tyr 
                325                 330                 335     


Asn Lys Asp Thr Lys Gly Ala Gln Leu Pro Ile Asp Asn Lys Leu Arg 
            340                 345                 350         


Leu Ser Leu Leu Tyr Ser Phe Met Arg Lys Leu Ser Ile Arg Ser Gly 
        355                 360                 365             


Val Glu Pro Thr Ile Thr Asn Ser Leu Asn Asp Arg Ser Thr Glu Lys 
    370                 375                 380                 


Lys Asn Gly Glu Arg Met Ala Asn Tyr Ile Phe Val Arg Ala His Asp 
385                 390                 395                 400 


Ser Glu Val Gln Thr Val Ile Ala Asp Ile Ile Arg Glu Asn Ile Asn 
                405                 410                 415     


Pro Asn Thr Asp Gly Leu Thr Phe Thr Met Asp Glu Leu Lys Gln Ala 
            420                 425                 430         


Phe Lys Ile Tyr Asn Glu Asp Met Arg Lys Ala Asp Lys Lys Tyr Thr 
        435                 440                 445             


Gln Phe Asn Ile Pro Thr Ala His Ala Leu Met Leu Ser Asn Lys Asp 
    450                 455                 460                 


Ser Ile Thr Arg Val Tyr Tyr Gly Asp Leu Tyr Thr Asp Asp Gly Gln 
465                 470                 475                 480 


Tyr Met Glu Lys Lys Ser Pro Tyr His Asp Ala Ile Asp Ala Leu Leu 
                485                 490                 495     


Arg Ala Arg Ile Lys Tyr Val Ala Gly Gly Gln Asp Met Lys Val Thr 
            500                 505                 510         


Tyr Met Gly Val Pro Arg Glu Ala Asp Lys Trp Ser Tyr Asn Gly Ile 
        515                 520                 525             


Leu Thr Ser Val Arg Tyr Gly Thr Gly Ala Asn Glu Ala Thr Asp Glu 
    530                 535                 540                 


Gly Thr Ala Glu Thr Arg Thr Gln Gly Met Ala Val Ile Ala Ser Asn 
545                 550                 555                 560 


Asn Pro Asn Leu Lys Leu Asn Glu Trp Asp Lys Leu Gln Val Asn Met 
                565                 570                 575     


Gly Ala Ala His Lys Asn Gln Tyr Tyr Arg Pro Val Leu Leu Thr Thr 
            580                 585                 590         


Lys Asp Gly Ile Ser Arg Tyr Leu Thr Asp Glu Glu Val Pro Gln Ser 
        595                 600                 605             


Leu Trp Lys Lys Thr Asp Ala Asn Gly Ile Leu Thr Phe Asp Met Asn 
    610                 615                 620                 


Asp Ile Ala Gly Tyr Ser Asn Val Gln Val Ser Gly Tyr Leu Ala Val 
625                 630                 635                 640 


Trp Val Pro Val Gly Ala Lys Ala Asp Gln Asp Ala Arg Val Thr Ala 
                645                 650                 655     


Ser Lys Lys Lys Asn Ala Ser Gly Gln Val Tyr Glu Ser Ser Ala Ala 
            660                 665                 670         


Leu Asp Ser Gln Leu Ile Tyr Glu Gly Phe Ser Asn Phe Gln Asp Phe 
        675                 680                 685             


Ala Thr Arg Asp Asp Gln Tyr Thr Asn Lys Val Ile Ala Lys Asn Val 
    690                 695                 700                 


Asn Leu Phe Lys Glu Trp Gly Val Thr Ser Phe Glu Leu Pro Pro Gln 
705                 710                 715                 720 


Tyr Val Ser Ser Gln Asp Gly Thr Phe Leu Asp Ser Ile Ile Gln Asn 
                725                 730                 735     


Gly Tyr Ala Phe Glu Asp Arg Tyr Asp Met Ala Met Ser Lys Asn Asn 
            740                 745                 750         


Lys Tyr Gly Ser Leu Asn Asp Leu Leu Asn Ala Leu Arg Ala Leu His 
        755                 760                 765             


Ser Val Asn Ile Gln Ala Ile Ala Asp Trp Val Pro Asp Gln Ile Tyr 
    770                 775                 780                 


Asn Leu Pro Gly Lys Glu Val Val Thr Ala Thr Arg Val Asn Asn Tyr 
785                 790                 795                 800 


Gly Thr Tyr Arg Glu Gly Ser Glu Ile Lys Glu Asn Leu Tyr Val Ala 
                805                 810                 815     


Asn Thr Lys Thr Asn Gly Thr Asp Tyr Gln Gly Lys Tyr Gly Gly Ala 
            820                 825                 830         


Phe Leu Asp Glu Leu Lys Ala Lys Tyr Pro Glu Ile Phe Glu Arg Val 
        835                 840                 845             


Gln Ile Ser Asn Gly Gln Lys Met Thr Thr Asp Glu Lys Ile Thr Lys 
    850                 855                 860                 


Trp Ser Ala Lys His Phe Asn Gly Thr Asn Ile Leu Gly Arg Gly Ala 
865                 870                 875                 880 


Tyr Tyr Val Leu Lys Asp Trp Ala Ser Asn Glu Tyr Leu Asn Asn Lys 
                885                 890                 895     


Asn Gly Glu Met Val Leu Pro Lys Gln Leu Val Asn Lys Asn Ala Tyr 
            900                 905                 910         


Thr Gly Phe Val Ser Asp Ala Ser Gly Thr Lys Tyr Tyr Ser Thr Ser 
        915                 920                 925             


Gly Tyr Gln Ala Arg Asn Ser Phe Ile Gln Asp Glu Asn Gly Asn Trp 
    930                 935                 940                 


Tyr Tyr Phe Asn Asn Arg Gly Tyr Leu Val Thr Gly Ala Gln Glu Ile 
945                 950                 955                 960 


Asp Gly Lys Gln Leu Tyr Phe Leu Lys Asn Gly Ile Gln Leu Arg Asp 
                965                 970                 975     


Ser Leu Arg Glu Asp Glu Asn Gly Asn Gln Tyr Tyr Tyr Asp Lys Thr 
            980                 985                 990         


Gly Ala Gln Val Leu Asn Arg Tyr  Tyr Thr Thr Asp Gly  Gln Asn Trp 
        995                 1000                 1005             


Arg Tyr  Phe Asp Val Lys Gly  Val Met Ala Arg Gly  Leu Val Thr 
    1010                 1015                 1020             


Met Gly  Gly Asn Gln Gln Phe  Phe Asp Gln Asn Gly  Tyr Gln Val 
    1025                 1030                 1035             


Lys Gly  Lys Ile Ala Arg Ala  Lys Asp Gly Lys Leu  Arg Tyr Phe 
    1040                 1045                 1050             


Asp Lys  Asp Ser Gly Asn Ala  Ala Ala Asn Arg Phe  Ala Gln Gly 
    1055                 1060                 1065             


Asp Asn  Pro Ser Asp Trp Tyr  Tyr Phe Gly Ala Asp  Gly Val Ala 
    1070                 1075                 1080             


Val Thr  Gly Leu Gln Lys Val  Gly Gln Gln Thr Leu  Tyr Phe Asp 
    1085                 1090                 1095             


Gln Asp  Gly Lys Gln Val Lys  Gly Lys Val Val Thr  Leu Ala Asp 
    1100                 1105                 1110             


Lys Ser  Ile Arg Tyr Phe Asp  Ala Asn Ser Gly Glu  Met Ala Val 
    1115                 1120                 1125             


Asn Lys  Phe Val Glu Gly Ala  Lys Asn Val Trp Tyr  Tyr Phe Asp 
    1130                 1135                 1140             


Gln Ala  Gly Lys Ala Val Thr  Gly Leu Gln Thr Ile  Asn Lys Gln 
    1145                 1150                 1155             


Val Leu  Tyr Phe Asp Gln Asp  Gly Lys Gln Val Lys  Gly Lys Val 
    1160                 1165                 1170             


Val Thr  Leu Ala Asp Lys Ser  Ile Arg Tyr Phe Asp  Ala Asn Ser 
    1175                 1180                 1185             


Gly Glu  Met Ala Val Gly Lys  Phe Ala Glu Gly Ala  Lys Asn Glu 
    1190                 1195                 1200             


Trp Tyr  Tyr Phe Asp Gln Ala  Gly Lys Ala Val Thr  Gly Leu Gln 
    1205                 1210                 1215             


Lys Ile  Gly Gln Gln Thr Leu  Tyr Phe Asp Gln Asn  Gly Lys Gln 
    1220                 1225                 1230             


Val Lys  Gly Lys Val Val Thr  Leu Ala Asp Lys Ser  Ile Arg Tyr 
    1235                 1240                 1245             


Phe Asp  Ala Asn Ser Gly Glu  Met Ala Ser Asn Lys  Phe Val Glu 
    1250                 1255                 1260             


Gly Ala  Lys Asn Glu Trp Tyr  Tyr Phe Asp Gln Ala  Gly Lys Ala 
    1265                 1270                 1275             


Val Thr  Gly Leu Gln Gln Ile  Gly Gln Gln Thr Leu  Tyr Phe Asp 
    1280                 1285                 1290             


Gln Asn  Gly Lys Gln Val Lys  Gly Lys Ile Val Tyr  Val Asn Gly 
    1295                 1300                 1305             


Ala Asn  Arg Tyr Phe Asp Ala  Asn Ser Gly Glu Met  Ala Arg Asn 
    1310                 1315                 1320             


Lys Trp  Ile Gln Leu Glu Asp  Gly Ser Trp Met Tyr  Phe Asp Arg 
    1325                 1330                 1335             


Asn Gly  Arg Gly Arg Arg Phe  Gly Trp Asn 
    1340                 1345             


<210>  9
<211>  3744
<212>  DNA
<213>  Streptococcus salivarius

<400>  9
atgccaagcc acattaagac catcaacggc aaacaatact acgtggagga tgacggtacg       60

attcgcaaga attacgtcct ggagcgtatc ggtggcagcc aatactttaa tgcagaaacc      120

ggtgaactgt ctaatcagaa agagtatcgt ttcgacaaaa atggtggtac tggtagcagc      180

gcggacagca cgaacaccaa cgtgactgtg aacggtgaca aaaacgcatt ttacggtacc      240

acggacaaag acattgagct ggtcgacggc tatttcaccg cgaacacctg gtatcgcccg      300

aaagaaatcc tgaaagacgg caaagaatgg accgccagca cggagaacga taaacgcccg      360

ctgctgaccg tctggtggcc tagcaaagca atccaggcgt cttatctgaa ctacatgaaa      420

gagcaaggcc tgggtaccaa ccaaacgtac acgagcttct ccagccaaac ccaaatggat      480

caagcagccc tggaagtgca aaagcgtatt gaagagcgca tcgcacgcga gggcaatacc      540

gactggctgc gcacgaccat caagaacttc gtgaaaaccc aaccgggttg gaacagcacc      600

tctgaaaatc tggacaataa tgatcatctg caaggtggcg ccctgctgta caataacgac      660

tcccgcacga gccacgcgaa cagcgactat cgcctgctga atcgtacgcc gaccagccag      720

accggcaaac acaatccgaa atacaccaaa gataccagca atggtggttt cgaatttctg      780

ctggcgaacg acatcgataa ctctaatccg gcggttcaag cagagcaact gaactggctg      840

cattacatta tgaacatcgg taccatcacg ggcggttctg aggatgaaaa cttcgacggc      900

gttcgtgttg acgctgtgga taatgtgaat gcggatctgc tgcaaatcgc gagcgactat      960

ttcaaagcaa aatacggtgc tgatcaaagc caagatcagg cgatcaaaca cttgagcatc     1020

ctggaagcgt ggtcccataa cgacgcctac tataacgaag ataccaaagg cgcgcagttg     1080

ccgatggatg atccgatgca cctggctctg gtctactcgc tgctgcgtcc gatcggcaat     1140

cgcagcggtg tggaaccgct gatttccaac agcctgaatg accgtagcga gtccggtaag     1200

aacagcaaac gtatggcgaa ctacgcgttc gtacgcgcgc atgatagcga ggtgcaatcg     1260

attattggcc agatcatcaa aaacgagatc aatccgcaaa gcaccggtaa tacgttcacc     1320

ctggatgaga tgaagaaagc gtttgagatt tacaacaagg atatgcgtag cgcgaataag     1380

cagtatacgc agtacaacat cccgagcgcg tatgcgttga tgctgaccca caaggatacc     1440

gttccgcgtg tgtattacgg tgatatgtat acggacgacg gtcagtacat ggcgcaaaag     1500

agcccatact atgatgcgat cgaaacgctg ctgaaaggtc gcatccgcta tgccgcaggt     1560

ggtcaggaca tgaaggtcaa ctatattggt tacggtaaca ctaacggctg ggatgctgcg     1620

ggcgtgctga ccagcgtacg ttatggcacg ggcgcaaata gcgccagcga tacgggtacc     1680

gccgaaacgc gtaatcaagg tatggcagtg attgttagca accaaccggc gctgcgtctg     1740

actagcaatt tgaccattaa catgggtgcc gcacaccgta atcaggctta ccgtccgctg     1800

ctgctgacga ccaacgatgg cgtcgcgacc tatttgaacg atagcgatgc gaatggtatc     1860

gttaagtaca ccgacggtaa tggtaatctg accttctccg caaacgagat tcgtggcatc     1920

cgtaacccgc aagttgatgg ctatctggcc gtctgggttc cggtaggtgc gtcggagaat     1980

caggatgttc gtgtggcgcc gagcaaagag aagaacagct ccggtctggt ttacgagagc     2040

aatgctgccc tggatagcca agttatctac gaaggcttca gcaacttcca ggacttcgtt     2100

cagaatccga gccagtatac caacaaaaag attgcagaga atgcaaattt gttcaaatcc     2160

tggggtatta ccagctttga atttgcgccg cagtacgtga gctcggatga tggtagcttc     2220

ctggacagcg ttattcagaa cggttatgcg tttacggacc gctacgacat tggtatgagc     2280

aaagacaaca aatatggttc gctggcggat ttgaaggcag cactgaagag cttgcatgcc     2340

gttggtatta gcgcaatcgc ggattgggtt cctgatcaga tctacaatct gccaggcgac     2400

gaggtcgtca ccgcaacccg cgttaacaac tacggcgaaa ccaaagatgg tgcaatcatt     2460

gatcactctt tgtacgcggc caaaacccgt acttttggta acgactacca gggtaagtat     2520

ggtggtgcgt tcctggacga gctgaaacgt ctgtatccgc agatctttga ccgcgttcag     2580

atttctaccg gtaagcgcat gaccacggac gagaagatca cccaatggtc tgcaaagtat     2640

atgaacggta cgaacatctt ggaccgtggc tctgaatacg ttttgaagaa tggtctgaat     2700

ggttactatg gcaccaatgg tggcaaagtt tcgctgccga aagttgtggg tagcaatcaa     2760

agcacgaatg gcgacaatca aaacggcgac ggtagcggca agtttgaaaa gcgtctgttc     2820

agcgtgcgtt accgttataa caatggccag tacgcgaaaa atgcctttat caaagataac     2880

gacggcaatg tttactattt cgacaatagc ggtcgtatgg ctgtcggtga gaaaacgatt     2940

gacggcaagc agtacttctt cctggctaat ggcgttcagc tgcgtgacgg ctaccgtcaa     3000

aatcgtcgcg gtcaggtgtt ttactacgac cagaatggtg tgctgaacgc aaacggtaaa     3060

caagacccga agcctgacaa caataacaat gcgagcggcc gtaatcaatt cgtccagatc     3120

ggtaacaacg tgtgggcgta ttatgatggc aatggtaaac gtgtcaccgg tcaccagaac     3180

atcaacggtc aggagttgtt tttcgataac aacggtgtcc aggttaaggg tcgtacggtg     3240

aatgagaacg gtgcaattcg ctactatgac gcgaatagcg gtgagatggc acgcaatcgt     3300

ttcgcggaga ttgaaccggg cgtctgggca tactttaaca atgacggcac cgcagtgaag     3360

ggttctcaga atatcaatgg tcaagacctg tacttcgacc agaacggtcg tcaggtcaag     3420

ggtgcgctgg ccaatgttga tggcaacctg cgctattacg acgttaacag cggtgagctg     3480

taccgtaatc gtttccacga aatcgacggc agctggtatt actttgatgg taacggtaat     3540

gcggtgaagg gtatggtcaa tatcaacggc caaaatctgt tgtttgacaa taacggcaaa     3600

cagattaagg gtcatctggt ccgcgtcaac ggcgtcgtgc gctattttga tccgaactct     3660

ggtgaaatgg cggttaatcg ttgggttgag gtgagcccag gttggtgggt ttactttgac     3720

ggtgaaggtc gtggtcagat ctaa                                            3744


<210>  10
<211>  1247
<212>  PRT
<213>  Streptococcus salivarius

<400>  10

Met Pro Ser His Ile Lys Thr Ile Asn Gly Lys Gln Tyr Tyr Val Glu 
1               5                   10                  15      


Asp Asp Gly Thr Ile Arg Lys Asn Tyr Val Leu Glu Arg Ile Gly Gly 
            20                  25                  30          


Ser Gln Tyr Phe Asn Ala Glu Thr Gly Glu Leu Ser Asn Gln Lys Glu 
        35                  40                  45              


Tyr Arg Phe Asp Lys Asn Gly Gly Thr Gly Ser Ser Ala Asp Ser Thr 
    50                  55                  60                  


Asn Thr Asn Val Thr Val Asn Gly Asp Lys Asn Ala Phe Tyr Gly Thr 
65                  70                  75                  80  


Thr Asp Lys Asp Ile Glu Leu Val Asp Gly Tyr Phe Thr Ala Asn Thr 
                85                  90                  95      


Trp Tyr Arg Pro Lys Glu Ile Leu Lys Asp Gly Lys Glu Trp Thr Ala 
            100                 105                 110         


Ser Thr Glu Asn Asp Lys Arg Pro Leu Leu Thr Val Trp Trp Pro Ser 
        115                 120                 125             


Lys Ala Ile Gln Ala Ser Tyr Leu Asn Tyr Met Lys Glu Gln Gly Leu 
    130                 135                 140                 


Gly Thr Asn Gln Thr Tyr Thr Ser Phe Ser Ser Gln Thr Gln Met Asp 
145                 150                 155                 160 


Gln Ala Ala Leu Glu Val Gln Lys Arg Ile Glu Glu Arg Ile Ala Arg 
                165                 170                 175     


Glu Gly Asn Thr Asp Trp Leu Arg Thr Thr Ile Lys Asn Phe Val Lys 
            180                 185                 190         


Thr Gln Pro Gly Trp Asn Ser Thr Ser Glu Asn Leu Asp Asn Asn Asp 
        195                 200                 205             


His Leu Gln Gly Gly Ala Leu Leu Tyr Asn Asn Asp Ser Arg Thr Ser 
    210                 215                 220                 


His Ala Asn Ser Asp Tyr Arg Leu Leu Asn Arg Thr Pro Thr Ser Gln 
225                 230                 235                 240 


Thr Gly Lys His Asn Pro Lys Tyr Thr Lys Asp Thr Ser Asn Gly Gly 
                245                 250                 255     


Phe Glu Phe Leu Leu Ala Asn Asp Ile Asp Asn Ser Asn Pro Ala Val 
            260                 265                 270         


Gln Ala Glu Gln Leu Asn Trp Leu His Tyr Ile Met Asn Ile Gly Thr 
        275                 280                 285             


Ile Thr Gly Gly Ser Glu Asp Glu Asn Phe Asp Gly Val Arg Val Asp 
    290                 295                 300                 


Ala Val Asp Asn Val Asn Ala Asp Leu Leu Gln Ile Ala Ser Asp Tyr 
305                 310                 315                 320 


Phe Lys Ala Lys Tyr Gly Ala Asp Gln Ser Gln Asp Gln Ala Ile Lys 
                325                 330                 335     


His Leu Ser Ile Leu Glu Ala Trp Ser His Asn Asp Ala Tyr Tyr Asn 
            340                 345                 350         


Glu Asp Thr Lys Gly Ala Gln Leu Pro Met Asp Asp Pro Met His Leu 
        355                 360                 365             


Ala Leu Val Tyr Ser Leu Leu Arg Pro Ile Gly Asn Arg Ser Gly Val 
    370                 375                 380                 


Glu Pro Leu Ile Ser Asn Ser Leu Asn Asp Arg Ser Glu Ser Gly Lys 
385                 390                 395                 400 


Asn Ser Lys Arg Met Ala Asn Tyr Ala Phe Val Arg Ala His Asp Ser 
                405                 410                 415     


Glu Val Gln Ser Ile Ile Gly Gln Ile Ile Lys Asn Glu Ile Asn Pro 
            420                 425                 430         


Gln Ser Thr Gly Asn Thr Phe Thr Leu Asp Glu Met Lys Lys Ala Phe 
        435                 440                 445             


Glu Ile Tyr Asn Lys Asp Met Arg Ser Ala Asn Lys Gln Tyr Thr Gln 
    450                 455                 460                 


Tyr Asn Ile Pro Ser Ala Tyr Ala Leu Met Leu Thr His Lys Asp Thr 
465                 470                 475                 480 


Val Pro Arg Val Tyr Tyr Gly Asp Met Tyr Thr Asp Asp Gly Gln Tyr 
                485                 490                 495     


Met Ala Gln Lys Ser Pro Tyr Tyr Asp Ala Ile Glu Thr Leu Leu Lys 
            500                 505                 510         


Gly Arg Ile Arg Tyr Ala Ala Gly Gly Gln Asp Met Lys Val Asn Tyr 
        515                 520                 525             


Ile Gly Tyr Gly Asn Thr Asn Gly Trp Asp Ala Ala Gly Val Leu Thr 
    530                 535                 540                 


Ser Val Arg Tyr Gly Thr Gly Ala Asn Ser Ala Ser Asp Thr Gly Thr 
545                 550                 555                 560 


Ala Glu Thr Arg Asn Gln Gly Met Ala Val Ile Val Ser Asn Gln Pro 
                565                 570                 575     


Ala Leu Arg Leu Thr Ser Asn Leu Thr Ile Asn Met Gly Ala Ala His 
            580                 585                 590         


Arg Asn Gln Ala Tyr Arg Pro Leu Leu Leu Thr Thr Asn Asp Gly Val 
        595                 600                 605             


Ala Thr Tyr Leu Asn Asp Ser Asp Ala Asn Gly Ile Val Lys Tyr Thr 
    610                 615                 620                 


Asp Gly Asn Gly Asn Leu Thr Phe Ser Ala Asn Glu Ile Arg Gly Ile 
625                 630                 635                 640 


Arg Asn Pro Gln Val Asp Gly Tyr Leu Ala Val Trp Val Pro Val Gly 
                645                 650                 655     


Ala Ser Glu Asn Gln Asp Val Arg Val Ala Pro Ser Lys Glu Lys Asn 
            660                 665                 670         


Ser Ser Gly Leu Val Tyr Glu Ser Asn Ala Ala Leu Asp Ser Gln Val 
        675                 680                 685             


Ile Tyr Glu Gly Phe Ser Asn Phe Gln Asp Phe Val Gln Asn Pro Ser 
    690                 695                 700                 


Gln Tyr Thr Asn Lys Lys Ile Ala Glu Asn Ala Asn Leu Phe Lys Ser 
705                 710                 715                 720 


Trp Gly Ile Thr Ser Phe Glu Phe Ala Pro Gln Tyr Val Ser Ser Asp 
                725                 730                 735     


Asp Gly Ser Phe Leu Asp Ser Val Ile Gln Asn Gly Tyr Ala Phe Thr 
            740                 745                 750         


Asp Arg Tyr Asp Ile Gly Met Ser Lys Asp Asn Lys Tyr Gly Ser Leu 
        755                 760                 765             


Ala Asp Leu Lys Ala Ala Leu Lys Ser Leu His Ala Val Gly Ile Ser 
    770                 775                 780                 


Ala Ile Ala Asp Trp Val Pro Asp Gln Ile Tyr Asn Leu Pro Gly Asp 
785                 790                 795                 800 


Glu Val Val Thr Ala Thr Arg Val Asn Asn Tyr Gly Glu Thr Lys Asp 
                805                 810                 815     


Gly Ala Ile Ile Asp His Ser Leu Tyr Ala Ala Lys Thr Arg Thr Phe 
            820                 825                 830         


Gly Asn Asp Tyr Gln Gly Lys Tyr Gly Gly Ala Phe Leu Asp Glu Leu 
        835                 840                 845             


Lys Arg Leu Tyr Pro Gln Ile Phe Asp Arg Val Gln Ile Ser Thr Gly 
    850                 855                 860                 


Lys Arg Met Thr Thr Asp Glu Lys Ile Thr Gln Trp Ser Ala Lys Tyr 
865                 870                 875                 880 


Met Asn Gly Thr Asn Ile Leu Asp Arg Gly Ser Glu Tyr Val Leu Lys 
                885                 890                 895     


Asn Gly Leu Asn Gly Tyr Tyr Gly Thr Asn Gly Gly Lys Val Ser Leu 
            900                 905                 910         


Pro Lys Val Val Gly Ser Asn Gln Ser Thr Asn Gly Asp Asn Gln Asn 
        915                 920                 925             


Gly Asp Gly Ser Gly Lys Phe Glu Lys Arg Leu Phe Ser Val Arg Tyr 
    930                 935                 940                 


Arg Tyr Asn Asn Gly Gln Tyr Ala Lys Asn Ala Phe Ile Lys Asp Asn 
945                 950                 955                 960 


Asp Gly Asn Val Tyr Tyr Phe Asp Asn Ser Gly Arg Met Ala Val Gly 
                965                 970                 975     


Glu Lys Thr Ile Asp Gly Lys Gln Tyr Phe Phe Leu Ala Asn Gly Val 
            980                 985                 990         


Gln Leu Arg Asp Gly Tyr Arg Gln  Asn Arg Arg Gly Gln  Val Phe Tyr 
        995                 1000                 1005             


Tyr Asp  Gln Asn Gly Val Leu  Asn Ala Asn Gly Lys  Gln Asp Pro 
    1010                 1015                 1020             


Lys Pro  Asp Asn Asn Asn Asn  Ala Ser Gly Arg Asn  Gln Phe Val 
    1025                 1030                 1035             


Gln Ile  Gly Asn Asn Val Trp  Ala Tyr Tyr Asp Gly  Asn Gly Lys 
    1040                 1045                 1050             


Arg Val  Thr Gly His Gln Asn  Ile Asn Gly Gln Glu  Leu Phe Phe 
    1055                 1060                 1065             


Asp Asn  Asn Gly Val Gln Val  Lys Gly Arg Thr Val  Asn Glu Asn 
    1070                 1075                 1080             


Gly Ala  Ile Arg Tyr Tyr Asp  Ala Asn Ser Gly Glu  Met Ala Arg 
    1085                 1090                 1095             


Asn Arg  Phe Ala Glu Ile Glu  Pro Gly Val Trp Ala  Tyr Phe Asn 
    1100                 1105                 1110             


Asn Asp  Gly Thr Ala Val Lys  Gly Ser Gln Asn Ile  Asn Gly Gln 
    1115                 1120                 1125             


Asp Leu  Tyr Phe Asp Gln Asn  Gly Arg Gln Val Lys  Gly Ala Leu 
    1130                 1135                 1140             


Ala Asn  Val Asp Gly Asn Leu  Arg Tyr Tyr Asp Val  Asn Ser Gly 
    1145                 1150                 1155             


Glu Leu  Tyr Arg Asn Arg Phe  His Glu Ile Asp Gly  Ser Trp Tyr 
    1160                 1165                 1170             


Tyr Phe  Asp Gly Asn Gly Asn  Ala Val Lys Gly Met  Val Asn Ile 
    1175                 1180                 1185             


Asn Gly  Gln Asn Leu Leu Phe  Asp Asn Asn Gly Lys  Gln Ile Lys 
    1190                 1195                 1200             


Gly His  Leu Val Arg Val Asn  Gly Val Val Arg Tyr  Phe Asp Pro 
    1205                 1210                 1215             


Asn Ser  Gly Glu Met Ala Val  Asn Arg Trp Val Glu  Val Ser Pro 
    1220                 1225                 1230             


Gly Trp  Trp Val Tyr Phe Asp  Gly Glu Gly Arg Gly  Gln Ile 
    1235                 1240                 1245         


