                         SEQUENCE LISTING

<110>  MacroGenics, Inc.
       Chi, Andrew S
 
<120>  Improved Methods for the Treatment of Vascularizing Cancers

<130>  1301.0113PCT

<150>  US 61/939,804
<151>  2014-02-14

<160>  110   

<170>  PatentIn version 3.5

<210>  1
<211>  316
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(316)
<223>  "2Ig" form of human B7-H3

<400>  1

Met Leu Arg Arg Arg Gly Ser Pro Gly Met Gly Val His Val Gly Ala 
1               5                   10                  15      


Ala Leu Gly Ala Leu Trp Phe Cys Leu Thr Gly Ala Leu Glu Val Gln 
            20                  25                  30          


Val Pro Glu Asp Pro Val Val Ala Leu Val Gly Thr Asp Ala Thr Leu 
        35                  40                  45              


Cys Cys Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn 
    50                  55                  60                  


Leu Ile Trp Gln Leu Thr Asp Thr Lys Gln Leu Val His Ser Phe Ala 
65                  70                  75                  80  


Glu Gly Gln Asp Gln Gly Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe 
                85                  90                  95      


Pro Asp Leu Leu Ala Gln Gly Asn Ala Ser Leu Arg Leu Gln Arg Val 
            100                 105                 110         


Arg Val Ala Asp Glu Gly Ser Phe Thr Cys Phe Val Ser Ile Arg Asp 
        115                 120                 125             


Phe Gly Ser Ala Ala Val Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys 
    130                 135                 140                 


Pro Ser Met Thr Leu Glu Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr 
145                 150                 155                 160 


Val Thr Ile Thr Cys Ser Ser Tyr Arg Gly Tyr Pro Glu Ala Glu Val 
                165                 170                 175     


Phe Trp Gln Asp Gly Gln Gly Val Pro Leu Thr Gly Asn Val Thr Thr 
            180                 185                 190         


Ser Gln Met Ala Asn Glu Gln Gly Leu Phe Asp Val His Ser Val Leu 
        195                 200                 205             


Arg Val Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn 
    210                 215                 220                 


Pro Val Leu Gln Gln Asp Ala His Gly Ser Val Thr Ile Thr Gly Gln 
225                 230                 235                 240 


Pro Met Thr Phe Pro Pro Glu Ala Leu Trp Val Thr Val Gly Leu Ser 
                245                 250                 255     


Val Cys Leu Ile Ala Leu Leu Val Ala Leu Ala Phe Val Cys Trp Arg 
            260                 265                 270         


Lys Ile Lys Gln Ser Cys Glu Glu Glu Asn Ala Gly Ala Glu Asp Gln 
        275                 280                 285             


Asp Gly Glu Gly Glu Gly Ser Lys Thr Ala Leu Gln Pro Leu Lys His 
    290                 295                 300                 


Ser Asp Ser Lys Glu Asp Asp Gly Gln Glu Ile Ala 
305                 310                 315     


<210>  2
<211>  948
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(948)
<223>  Polynucleotide Sequence Encoding the "2Ig" Form of Human B7-H3

<400>  2
atgctgcgtc ggcggggcag ccctggcatg ggtgtgcatg tgggtgcagc cctgggagca       60

ctgtggttct gcctcacagg agccctggag gtccaggtcc ctgaagaccc agtggtggca      120

ctggtgggca ccgatgccac cctgtgctgc tccttctccc ctgagcctgg cttcagcctg      180

gcacagctca acctcatctg gcagctgaca gataccaaac agctggtgca cagctttgct      240

gagggccagg accagggcag cgcctatgcc aaccgcacgg ccctcttccc ggacctgctg      300

gcacagggca acgcatccct gaggctgcag cgcgtgcgtg tggcggacga gggcagcttc      360

acctgcttcg tgagcatccg ggatttcggc agcgctgccg tcagcctgca ggtggccgct      420

ccctactcga agcccagcat gaccctggag cccaacaagg acctgcggcc aggggacacg      480

gtgaccatca cgtgctccag ctaccggggc taccctgagg ctgaggtgtt ctggcaggat      540

gggcagggtg tgcccctgac tggcaacgtg accacgtcgc agatggccaa cgagcagggc      600

ttgtttgatg tgcacagcgt cctgcgggtg gtgctgggtg cgaatggcac ctacagctgc      660

ctggtgcgca accccgtgct gcagcaggat gcgcacggct ctgtcaccat cacagggcag      720

cctatgacat tccccccaga ggccctgtgg gtgaccgtgg ggctgtctgt ctgtctcatt      780

gcactgctgg tggccctggc tttcgtgtgc tggagaaaga tcaaacagag ctgtgaggag      840

gagaatgcag gagctgagga ccaggatggg gagggagaag gctccaagac agccctgcag      900

cctctgaaac actctgacag caaagaagat gatggacaag aaatagcc                   948


<210>  3
<211>  534
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(534)
<223>  "4Ig" form of human B7-H3

<400>  3

Met Leu Arg Arg Arg Gly Ser Pro Gly Met Gly Val His Val Gly Ala 
1               5                   10                  15      


Ala Leu Gly Ala Leu Trp Phe Cys Leu Thr Gly Ala Leu Glu Val Gln 
            20                  25                  30          


Val Pro Glu Asp Pro Val Val Ala Leu Val Gly Thr Asp Ala Thr Leu 
        35                  40                  45              


Cys Cys Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn 
    50                  55                  60                  


Leu Ile Trp Gln Leu Thr Asp Thr Lys Gln Leu Val His Ser Phe Ala 
65                  70                  75                  80  


Glu Gly Gln Asp Gln Gly Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe 
                85                  90                  95      


Pro Asp Leu Leu Ala Gln Gly Asn Ala Ser Leu Arg Leu Gln Arg Val 
            100                 105                 110         


Arg Val Ala Asp Glu Gly Ser Phe Thr Cys Phe Val Ser Ile Arg Asp 
        115                 120                 125             


Phe Gly Ser Ala Ala Val Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys 
    130                 135                 140                 


Pro Ser Met Thr Leu Glu Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr 
145                 150                 155                 160 


Val Thr Ile Thr Cys Ser Ser Tyr Gln Gly Tyr Pro Glu Ala Glu Val 
                165                 170                 175     


Phe Trp Gln Asp Gly Gln Gly Val Pro Leu Thr Gly Asn Val Thr Thr 
            180                 185                 190         


Ser Gln Met Ala Asn Glu Gln Gly Leu Phe Asp Val His Ser Ile Leu 
        195                 200                 205             


Arg Val Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn 
    210                 215                 220                 


Pro Val Leu Gln Gln Asp Ala His Ser Ser Val Thr Ile Thr Pro Gln 
225                 230                 235                 240 


Arg Ser Pro Thr Gly Ala Val Glu Val Gln Val Pro Glu Asp Pro Val 
                245                 250                 255     


Val Ala Leu Val Gly Thr Asp Ala Thr Leu Arg Cys Ser Phe Ser Pro 
            260                 265                 270         


Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn Leu Ile Trp Gln Leu Thr 
        275                 280                 285             


Asp Thr Lys Gln Leu Val His Ser Phe Thr Glu Gly Arg Asp Gln Gly 
    290                 295                 300                 


Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe Pro Asp Leu Leu Ala Gln 
305                 310                 315                 320 


Gly Asn Ala Ser Leu Arg Leu Gln Arg Val Arg Val Ala Asp Glu Gly 
                325                 330                 335     


Ser Phe Thr Cys Phe Val Ser Ile Arg Asp Phe Gly Ser Ala Ala Val 
            340                 345                 350         


Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys Pro Ser Met Thr Leu Glu 
        355                 360                 365             


Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr Val Thr Ile Thr Cys Ser 
    370                 375                 380                 


Ser Tyr Arg Gly Tyr Pro Glu Ala Glu Val Phe Trp Gln Asp Gly Gln 
385                 390                 395                 400 


Gly Val Pro Leu Thr Gly Asn Val Thr Thr Ser Gln Met Ala Asn Glu 
                405                 410                 415     


Gln Gly Leu Phe Asp Val His Ser Val Leu Arg Val Val Leu Gly Ala 
            420                 425                 430         


Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn Pro Val Leu Gln Gln Asp 
        435                 440                 445             


Ala His Gly Ser Val Thr Ile Thr Gly Gln Pro Met Thr Phe Pro Pro 
    450                 455                 460                 


Glu Ala Leu Trp Val Thr Val Gly Leu Ser Val Cys Leu Ile Ala Leu 
465                 470                 475                 480 


Leu Val Ala Leu Ala Phe Val Cys Trp Arg Lys Ile Lys Gln Ser Cys 
                485                 490                 495     


Glu Glu Glu Asn Ala Gly Ala Glu Asp Gln Asp Gly Glu Gly Glu Gly 
            500                 505                 510         


Ser Lys Thr Ala Leu Gln Pro Leu Lys His Ser Asp Ser Lys Glu Asp 
        515                 520                 525             


Asp Gly Gln Glu Ile Ala 
    530                 


<210>  4
<211>  1602
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1602)
<223>  Polynucleotide Sequence Encoding the "4Ig" Form of Human B7-H3

<400>  4
atgctgcgtc ggcggggcag ccctggcatg ggtgtgcatg tgggtgcagc cctgggagca       60

ctgtggttct gcctcacagg agccctggag gtccaggtcc ctgaagaccc agtggtggca      120

ctggtgggca ccgatgccac cctgtgctgc tccttctccc ctgagcctgg cttcagcctg      180

gcacagctca acctcatctg gcagctgaca gataccaaac agctggtgca cagctttgct      240

gagggccagg accagggcag cgcctatgcc aaccgcacgg ccctcttccc ggacctgctg      300

gcacagggca acgcatccct gaggctgcag cgcgtgcgtg tggcggacga gggcagcttc      360

acctgcttcg tgagcatccg ggatttcggc agcgctgccg tcagcctgca ggtggccgct      420

ccctactcga agcccagcat gaccctggag cccaacaagg acctgcggcc aggggacacg      480

gtgaccatca cgtgctccag ctaccagggc taccctgagg ctgaggtgtt ctggcaggat      540

gggcagggtg tgcccctgac tggcaacgtg accacgtcgc agatggccaa cgagcagggc      600

ttgtttgatg tgcacagcat cctgcgggtg gtgctgggtg caaatggcac ctacagctgc      660

ctggtgcgca accccgtgct gcagcaggat gcgcacagct ctgtcaccat cacaccccag      720

agaagcccca caggagccgt ggaggtccag gtccctgagg acccggtggt ggccctagtg      780

ggcaccgatg ccaccctgcg ctgctccttc tcccccgagc ctggcttcag cctggcacag      840

ctcaacctca tctggcagct gacagacacc aaacagctgg tgcacagttt caccgaaggc      900

cgggaccagg gcagcgccta tgccaaccgc acggccctct tcccggacct gctggcacaa      960

ggcaatgcat ccctgaggct gcagcgcgtg cgtgtggcgg acgagggcag cttcacctgc     1020

ttcgtgagca tccgggattt cggcagcgct gccgtcagcc tgcaggtggc cgctccctac     1080

tcgaagccca gcatgaccct ggagcccaac aaggacctgc ggccagggga cacggtgacc     1140

atcacgtgct ccagctaccg gggctaccct gaggctgagg tgttctggca ggatgggcag     1200

ggtgtgcccc tgactggcaa cgtgaccacg tcgcagatgg ccaacgagca gggcttgttt     1260

gatgtgcaca gcgtcctgcg ggtggtgctg ggtgcgaatg gcacctacag ctgcctggtg     1320

cgcaaccccg tgctgcagca ggatgcgcac ggctctgtca ccatcacagg gcagcctatg     1380

acattccccc cagaggccct gtgggtgacc gtggggctgt ctgtctgtct cattgcactg     1440

ctggtggccc tggctttcgt gtgctggaga aagatcaaac agagctgtga ggaggagaat     1500

gcaggagctg aggaccagga tggggaggga gaaggctcca agacagccct gcagcctctg     1560

aaacactctg acagcaaaga agatgatgga caagaaatag cc                        1602


<210>  5
<211>  107
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(107)
<223>  Amino Acid Sequence of BRCA69D Variable Light Chain

<400>  5

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Asp Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  6
<211>  321
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(321)
<223>  Polynucleotide Sequence Encoding BRCA69D Variable Light Chain

<400>  6
gatatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgca gggcaagtca ggacattagt aattatttaa actggtatca gcagaaacca      120

gatggaactg ttaaactcct gatctactac acatcacgat tacactcagg agtcccatca      180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattgacaa cctggagcaa      240

gaagatattg ccacttactt ttgccaacag ggtaatacgc ttcctccgac gttcggtgga      300

ggcaccaaac tggaaatcaa a                                                321


<210>  7
<211>  11
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(11)
<223>  BRCA69D Variable Light Chain CDR1

<400>  7

Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  8
<211>  33
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(33)
<223>  Polynucleotide Sequence Encoding BRCA69D Variable Light Chain 
       CDR1

<400>  8
agggcaagtc aggacattag taattattta aac                                    33


<210>  9
<211>  7
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  BRCA69D Variable Light Chain CDR2

<400>  9

Tyr Thr Ser Arg Leu His Ser 
1               5           


<210>  10
<211>  21
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  Polynucleotide Sequence Encoding BRCA69D Variable Light Chain 
       CDR2

<400>  10
tacacatcac gattacactc a                                                 21


<210>  11
<211>  9
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(9)
<223>  BRCA69D Variable Light Chain CDR3

<400>  11

Gln Gln Gly Asn Thr Leu Pro Pro Thr 
1               5                   


<210>  12
<211>  27
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(27)
<223>  Polynucleotide Sequence Encoding BRCA69D Variable Light Chain 
       CDR3

<400>  12
caacagggta atacgcttcc tccgacg                                           27


<210>  13
<211>  120
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(120)
<223>  Amino Acid Sequence of BRCA69D Variable Heavy Chain

<400>  13

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met Gln Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Thr Ile Tyr Pro Gly Asp Gly Asp Thr Arg Tyr Thr Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Ile Pro Arg Leu Trp Tyr Phe Asp Val Trp Gly Ala 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  14
<211>  360
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(360)
<223>  Polynucleotide Sequence Encoding BRCA69D Variable Heavy Chain

<400>  14
caggttcagc tccagcagtc tggggctgag ctggcaagac ctggggcttc agtgaagttg       60

tcctgcaagg cttctggcta cacctttact agctactgga tgcagtgggt aaaacagagg      120

cctggacagg gtctggaatg gattgggact atttatcctg gagatggtga tactaggtac      180

actcagaagt tcaagggcaa ggccacattg actgcagata aatcctccag cacagcctac      240

atgcaactca gcagcttggc atctgaggac tctgcggtct attactgtgc aagaagaggg      300

attccacggc tttggtactt cgatgtctgg ggcgcaggga ccacggtcac cgtctcctca      360


<210>  15
<211>  5
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  BRCA69D Variable Heavy Chain CDR1

<400>  15

Ser Tyr Trp Met Gln 
1               5   


<210>  16
<211>  15
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  Polynucleotide Sequence Encoding BRCA69D Variable Heavy Chain 
       CDR1

<400>  16
agctactgga tgcag                                                        15


<210>  17
<211>  17
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  BRCA69D Variable Heavy Chain CDR2

<400>  17

Thr Ile Tyr Pro Gly Asp Gly Asp Thr Arg Tyr Thr Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  18
<211>  51
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(51)
<223>  Polynucleotide Sequence Encoding BRCA69D Variable Heavy Chain 
       CDR2

<400>  18
actatttatc ctggagatgg tgatactagg tacactcaga agttcaaggg c                51


<210>  19
<211>  11
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(11)
<223>  BRCA69D Variable Heavy Chain CDR3

<400>  19

Arg Gly Ile Pro Arg Leu Trp Tyr Phe Asp Val 
1               5                   10      


<210>  20
<211>  33
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(33)
<223>  Polynucleotide Sequence Encoding BRCA69D Variable Heavy Chain 
       CDR3

<400>  20
agagggattc cacggctttg gtacttcgat gtc                                    33


<210>  21
<211>  108
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(108)
<223>  Amino Acid Sequence of PRCA157 Variable Light Chain

<400>  21

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Ile Tyr Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Asn Thr Lys Thr Leu Pro Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Arg Tyr Tyr Cys Gln His His Tyr Gly Thr Pro Pro 
                85                  90                  95      


Trp Thr Phe Gly Gly Gly Thr Asn Leu Glu Ile Lys 
            100                 105             


<210>  22
<211>  324
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(324)
<223>  Polynucleotide Sequence Encoding PRCA157 Variable Light Chain

<400>  22
gacatccaga tgactcagtc tccagcctcc ctatctgtat ctgtgggaga aactgtcacc       60

attacatgtc gagcaagtga gagtatttac agttatttag catggtatca gcagaaacag      120

ggaaaatctc ctcagctcct ggtctataat acaaaaacct taccagaggg tgtgccatca      180

aggttcagtg gcagtggatc aggcacacag ttttctctga agatcaacag cctgcagcct      240

gaagattttg ggagatatta ctgtcaacat cattatggta ctcctccgtg gacgttcggt      300

ggaggcacca acctggaaat caaa                                             324


<210>  23
<211>  11
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(11)
<223>  PRCA157 Variable Light Chain CDR1

<400>  23

Arg Ala Ser Glu Ser Ile Tyr Ser Tyr Leu Ala 
1               5                   10      


<210>  24
<211>  33
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(33)
<223>  Polynucleotide Sequence Encoding PRCA157 Variable Light Chain 
       CDR1

<400>  24
cgagcaagtg agagtattta cagttattta gca                                    33


<210>  25
<211>  7
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  PRCA157 Variable Light Chain CDR2

<400>  25

Asn Thr Lys Thr Leu Pro Glu 
1               5           


<210>  26
<211>  21
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  Polynucleotide Sequence Encoding PRCA157 Variable Light Chain 
       CDR2

<400>  26
aatacaaaaa ccttaccaga g                                                 21


<210>  27
<211>  9
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(9)
<223>  PRCA157 Variable Light Chain CDR3

<400>  27

Gln His His Tyr Gly Thr Pro Pro Trp 
1               5                   


<210>  28
<211>  27
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(27)
<223>  Polynucleotide Sequence Encoding PRCA157 Variable Light Chain 
       CDR3

<400>  28
caacatcatt atggtactcc tccgtgg                                           27


<210>  29
<211>  117
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(117)
<223>  Amino Acid Sequence of PRCA157 Variable Heavy Chain

<400>  29

Glu Val Gln Gln Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Asn Ser Gly Gly Ser Asn Thr Tyr Tyr Pro Asp Ser Leu 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Arg Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Asp Gly Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  30
<211>  351
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(351)
<223>  Polynucleotide Sequence Encoding PRCA157 Variable Heavy Chain

<400>  30
gaggtgcagc aggtggagtc ggggggagac ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt tcctatggca tgtcttgggt tcgccagact      120

ccagacaaga ggctggagtg ggtcgcaacc attaatagtg gtggaagtaa cacctactat      180

ccagacagtt tgaaggggcg attcaccatc tccagagaca atgccaagaa caccctttac      240

ctgcaaatgc gcagtctgaa gtctgaggac acagccatgt attactgtgc aagacatgac      300

gggggagcta tggactactg gggtcaagga acctcagtca ccgtctcctc a               351


<210>  31
<211>  5
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  PRCA157 Variable Heavy Chain CDR1

<400>  31

Ser Tyr Gly Met Ser 
1               5   


<210>  32
<211>  15
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  Polynucleotide Sequence Encoding PRCA157 Variable Heavy Chain 
       CDR1

<400>  32
tcctatggca tgtct                                                        15


<210>  33
<211>  19
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(19)
<223>  PRCA157 Variable Heavy Chain CDR2

<400>  33

Val Ala Thr Ile Asn Ser Gly Gly Ser Asn Thr Tyr Tyr Pro Asp Ser 
1               5                   10                  15      


Leu Lys Gly 
            


<210>  34
<211>  57
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(57)
<223>  Polynucleotide Sequence Encoding PRCA157 Variable Heavy Chain 
       CDR2

<400>  34
gtcgcaacca ttaatagtgg tggaagtaac acctactatc cagacagttt gaagggg          57


<210>  35
<211>  8
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  PRCA157 Variable Heavy Chain CDR3

<400>  35

His Asp Gly Gly Ala Met Asp Tyr 
1               5               


<210>  36
<211>  24
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(24)
<223>  Polynucleotide Sequence Encoding PRCA157 Variable Heavy Chain 
       CDR3

<400>  36
catgacgggg gagctatgga ctac                                              24


<210>  37
<211>  107
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(107)
<223>  Amino Acid Sequence of BRCA84D Variable Light Chain

<400>  37

Asp Ile Ala Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Asp Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Asn Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  38
<211>  321
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(321)
<223>  Polynucleotide Sequence Encoding BRCA84D Variable Light Chain

<400>  38
gacattgcga tgacccagtc tcaaaaattc atgtccacat cagtaggaga cagggtcagc       60

gtcacctgca aggccagtca gaatgtggat actaatgtag cctggtatca acagaaacca      120

gggcaatctc ctaaagcact gatttactcg gcatcctacc ggtacagtgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat ttcactctca ccatcaacaa tgtgcagtct      240

gaagacttgg cagagtattt ctgtcagcaa tataacaact atccattcac gttcggctcg      300

gggacaaagt tggaaataaa a                                                321


<210>  39
<211>  11
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(11)
<223>  BRCA84D Variable Light Chain CDR1

<400>  39

Lys Ala Ser Gln Asn Val Asp Thr Asn Val Ala 
1               5                   10      


<210>  40
<211>  33
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(33)
<223>  Polynucleotide Sequence Encoding BRCA84D Variable Light Chain 
       CDR1

<400>  40
aaggccagtc agaatgtgga tactaatgta gcc                                    33


<210>  41
<211>  7
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  BRCA84D Variable Light Chain CDR2

<400>  41

Ser Ala Ser Tyr Arg Tyr Ser 
1               5           


<210>  42
<211>  21
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(21)
<223>  Polynucleotide Sequence Encoding BRCA84D Variable Light Chain 
       CDR2

<400>  42

Thr Cys Gly Gly Cys Ala Thr Cys Cys Thr Ala Cys Cys Gly Gly Thr 
1               5                   10                  15      


Ala Cys Ala Gly Thr 
            20      


<210>  43
<211>  9
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(9)
<223>  BRCA84D Variable Light Chain CDR3

<400>  43

Gln Gln Tyr Asn Asn Tyr Pro Phe Thr 
1               5                   


<210>  44
<211>  27
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(27)
<223>  Polynucleotide Sequence Encoding BRCA84D Variable Light Chain 
       CDR3

<400>  44
cagcaatata acaactatcc attcacg                                           27


<210>  45
<211>  122
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  Amino Acid Sequence of BRCA84D Variable Heavy Chain

<400>  45

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Asp Ser Ser Ala Ile Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Gly Arg Gly Arg Glu Asn Ile Tyr Tyr Gly Ser Arg Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120         


<210>  46
<211>  366
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(366)
<223>  Polynucleotide Sequence Encoding BRCA84D Variable Heavy Chain

<400>  46
gatgtgcagc tggtggagtc tgggggaggc ttagtgcagc ctggagggtc ccggaaactc       60

tcctgtgcag cctctggatt cactttcagt agctttggaa tgcactgggt tcgtcaggct      120

ccagagaagg ggctggagtg ggtcgcatac attagtagtg acagtagtgc catctactat      180

gcagacacag tgaagggccg attcaccatc tccagagaca atcccaagaa caccctgttc      240

ctgcaaatga ccagtctaag gtctgaggac acggccatgt attactgtgg aagagggagg      300

gaaaacattt actacggtag taggcttgac tactggggcc aaggcaccac tctcacagtc      360

tcctca                                                                 366


<210>  47
<211>  4
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(4)
<223>  BRCA84D Variable Heavy Chain CDR1

<400>  47

Phe Gly Met His 
1               


<210>  48
<211>  12
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  Polynucleotide Sequence Encoding BRCA84D Variable Heavy Chain 
       CDR1

<400>  48
tttggaatgc ac                                                           12


<210>  49
<211>  16
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(16)
<223>  BRCA84D Variable Heavy Chain CDR2

<400>  49

Tyr Ile Ser Ser Asp Ser Ser Ala Ile Tyr Tyr Ala Asp Thr Val Lys 
1               5                   10                  15      


<210>  50
<211>  48
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(48)
<223>  Polynucleotide Sequence Encoding BRCA84D Variable Heavy Chain 
       CDR2

<400>  50
tacattagta gtgacagtag tgccatctac tatgcagaca cagtgaag                    48


<210>  51
<211>  13
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  BRCA84D Variable Heavy Chain CDR3

<400>  51

Gly Arg Glu Asn Ile Tyr Tyr Gly Ser Arg Leu Asp Tyr 
1               5                   10              


<210>  52
<211>  39
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(39)
<223>  Polynucleotide Sequence Encoding BRCA84D Variable Heavy Chain 
       CDR3

<400>  52
gggagggaaa acatttacta cggtagtagg cttgactac                              39


<210>  53
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized BRCA84D-1 Variable Light Chain

<400>  53

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Asp Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Asn Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  54
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Sequence Encoding Humanized BRCA84D-1 Variable 
       Light Chain

<400>  54
gacatccagc tgacccagtc cccctccttc ctgtctgcct ccgtgggcga cagagtgacc       60

atcacatgca aggcctccca gaacgtggac accaacgtgg cctggtatca gcagaagcct      120

ggcaaggccc ctaagctgct gatctactcc gcctcctacc ggtactccgg cgtgccttcc      180

aggttctccg gctccggctc tggcaccgac ttcaccctga ccatctccag cctgcagcct      240

gaggacttcg ccacctacta ctgccagcag tacaacaact accctttcac cttcggccag      300

ggcaccaagc tggaaatcaa g                                                321


<210>  55
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized BRCA84D-1 Variable Light Chain CDR1

<400>  55

Lys Ala Ser Gln Asn Val Asp Thr Asn Val Ala 
1               5                   10      


<210>  56
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Sequence Encoding Humanized BRCA84D-1 Variable 
       Light Chain CDR1

<400>  56
aaggccagtc agaatgtgga tactaatgta gcc                                    33


<210>  57
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized BRCA84D-1 Variable Light Chain CDR2

<400>  57

Ser Ala Ser Tyr Arg Tyr Ser 
1               5           


<210>  58
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Sequence Encoding Humanized BRCA84D-1 Variable 
       Light Chain CDR2

<400>  58
tcggcatcct accggtacag t                                                 21


<210>  59
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized BRCA84D-1 Variable Light Chain CDR3

<400>  59

Gln Gln Tyr Asn Asn Tyr Pro Phe Thr 
1               5                   


<210>  60
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Sequence Encoding Humanized BRCA84D-1 Variable 
       Light Chain CDR3

<400>  60
cagcaatata acaactatcc attcacg                                           27


<210>  61
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of Humanized BRCA84D-1 Variable Heavy Chain

<400>  61

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Asp Ser Ser Ala Ile Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Glu Asn Ile Tyr Tyr Gly Ser Arg Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  62
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Sequence Encoding Humanized BRCA84D-1 Variable 
       Heavy Chain

<400>  62
gaggtgcagc tggtcgagtc tggcggagga ctggtgcagc ctggcggctc cctgagactg       60

tcttgcgccg cctccggctt caccttctcc agcttcggca tgcactgggt ccgccaggct      120

ccaggcaagg gactggaatg ggtggcctac atctcctccg actcctccgc catctactac      180

gccgacaccg tgaagggcag gttcaccatc tcccgggaca acgccaagaa ctccctgtac      240

ctgcagatga actccctgcg ggacgaggac accgccgtgt actactgcgc cagaggccgg      300

gagaatatct actacggctc ccggctggat tattggggcc agggcaccac cgtgaccgtg      360

tcctct                                                                 366


<210>  63
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized BRCA84D-1 Variable Heavy Chain CDR1

<400>  63

Phe Gly Met His 
1               


<210>  64
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Sequence Encoding Humanized BRCA84D-1 Variable 
       Heavy Chain CDR1

<400>  64
tttggaatgc ac                                                           12


<210>  65
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized BRCA84D Variable Heavy Chain CDR2

<400>  65

Tyr Ile Ser Ser Asp Ser Ser Ala Ile Tyr Tyr Ala Asp Thr Val Lys 
1               5                   10                  15      


<210>  66
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Sequence Encoding Humanized BRCA84D-1 Variable 
       Heavy Chain CDR2

<400>  66
tacattagta gtgacagtag tgccatctac tatgcagaca cagtgaag                    48


<210>  67
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized BRCA84D-1 Variable Heavy Chain CDR3

<400>  67

Gly Arg Glu Asn Ile Tyr Tyr Gly Ser Arg Leu Asp Tyr 
1               5                   10              


<210>  68
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Sequence Encoding Humanized BRCA84D-1 Variable 
       Heavy Chain CDR3

<400>  68
gggagggaaa acatttacta cggtagtagg cttgactac                              39


<210>  69
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of hBRCA84D-2VL

<400>  69

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Asp Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Asn Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  70
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding hBRCA84D-2VL

<400>  70
gacatccagc tgacccagtc cccctccttc ctgtctgcct ccgtgggcga cagagtgacc       60

atcacatgca aggcctccca gaacgtggac accaacgtgg cctggtatca gcagaagcct      120

ggcaaggccc ctaaggcgct gatctactcc gcctcctacc ggtactccgg cgtgccttcc      180

aggttctccg gctccggctc tggcaccgac ttcaccctga ccatctccag cctgcagcct      240

gaggacttcg ccacctacta ctgccagcag tacaacaact accctttcac cttcggccag      300

ggcaccaagc tggaaatcaa g                                                321


<210>  71
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of hBRCA84D-3VL

<400>  71

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Asp Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Asn Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  72
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding hBRCA84D-3VL

<400>  72
gacatccagc tgacccagtc cccctccttc ctgtctgcct ccgtgggcga cagagtgtcc       60

gtcacatgca aggcctccca gaacgtggac accaacgtgg cctggtatca gcagaagcct      120

ggcaaggccc ctaagctgct gatctactcc gcctcctacc ggtactccgg cgtgccttcc      180

aggttctccg gctccggctc tggcaccgac ttcaccctga ccatctccag cctgcagcct      240

gaggacttcg ccacctacta ctgccagcag tacaacaact accctttcac cttcggccag      300

ggcaccaagc tggaaatcaa g                                                321


<210>  73
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of hBRCA84D-4VL

<400>  73

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Asp Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Asn Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  74
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding hBRCA84D-4VL

<400>  74
gacatccagc tgacccagtc cccctccttc ctgtctgcct ccgtgggcga cagagtgacc       60

atcacatgca aggcctccca gaacgtggac accaacgtgg cctggtatca gcagaagcct      120

ggccaggccc ctaagctgct gatctactcc gcctcctacc ggtactccgg cgtgccttcc      180

aggttctccg gctccggctc tggcaccgac ttcaccctga ccatctccag cctgcagcct      240

gaggacttcg ccacctacta ctgccagcag tacaacaact accctttcac cttcggccag      300

ggcaccaagc tggaaatcaa g                                                321


<210>  75
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of hBRCA84D-5VL

<400>  75

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Asp Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Asn Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  76
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding hBRCA84D-5VL

<400>  76
gacatccagc tgacccagtc cccctccttc ctgtctgcct ccgtgggcga cagagtgacc       60

atcacatgca aggcctccca gaacgtggac accaacgtgg cctggtatca gcagaagcct      120

ggccaggccc ctaaggcgct gatctactcc gcctcctacc ggtactccgg cgtgccttcc      180

aggttctccg gctccggctc tggcaccgac ttcaccctga ccatctccag cctgcagcct      240

gaggacttcg ccacctacta ctgccagcag tacaacaact accctttcac cttcggccag      300

ggcaccaagc tggaaatcaa g                                                321


<210>  77
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of hBRCA84D-6VL

<400>  77

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Asp Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Glu Tyr Tyr Cys Gln Gln Tyr Asn Asn Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  78
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding hBRCA84D-6VL

<400>  78
gacatccagc tgacccagtc cccctccttc ctgtctgcct ccgtgggcga cagagtgacc       60

atcacatgca aggcctccca gaacgtggac accaacgtgg cctggtatca gcagaagcct      120

ggcaaggccc ctaagctgct gatctactcc gcctcctacc ggtactccgg cgtgccttcc      180

aggttctccg gctccggctc tggcaccgac ttcaccctga ccatctccag cctgcagcct      240

gaggacttcg ccgagtacta ctgccagcag tacaacaact accctttcac cttcggccag      300

ggcaccaagc tggaaatcaa g                                                321


<210>  79
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of hBRCA84D-2VH

<400>  79

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Asp Ser Ser Ala Ile Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gly Arg Gly Arg Glu Asn Ile Tyr Tyr Gly Ser Arg Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  80
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding hBRCA84D-2VH

<400>  80
gaggtgcagc tggtcgagtc tggcggagga ctggtgcagc ctggcggctc cctgagactg       60

tcttgcgccg cctccggctt caccttctcc agcttcggca tgcactgggt ccgccaggct      120

ccaggcaagg gactggaatg ggtggcctac atctcctccg actcctccgc catctactac      180

gccgacaccg tgaagggcag gttcaccatc tcccgggaca acgccaagaa ctccctgtac      240

ctgcagatga actccctgcg ggacgaggac accgccgtgt actactgcgg cagaggccgg      300

gagaatatct actacggctc ccggctggat tattggggcc agggcaccac cgtgaccgtg      360

tcctct                                                                 366


<210>  81
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of hBRCA84D-3VH

<400>  81

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Asp Ser Ser Ala Ile Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Gly Arg Gly Arg Glu Asn Ile Tyr Tyr Gly Ser Arg Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  82
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding hBRCA84D-3VH

<400>  82
gaggtgcagc tggtcgagtc tggcggagga ctggtgcagc ctggcggctc cctgagactg       60

tcttgcgccg cctccggctt caccttctcc agcttcggca tgcactgggt ccgccaggct      120

ccaggcaagg gactggaatg ggtggcctac atctcctccg actcctccgc catctactac      180

gccgacaccg tgaagggcag gttcaccatc tcccgggaca acgccaagaa ctccctgtac      240

ctgcagatga actccctgcg ggacgaggac accgccatgt actactgcgg cagaggccgg      300

gagaatatct actacggctc ccggctggat tattggggcc agggcaccac cgtgaccgtg      360

tcctct                                                                 366


<210>  83
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of hBRCA84D-4VH

<400>  83

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Asp Ser Ser Ala Ile Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Glu Asn Ile Tyr Tyr Gly Ser Arg Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  84
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding hBRCA84D-4VH

<400>  84
gaggtgcagc tggtcgagtc tggcggagga ctggtgcagc ctggcggctc cctgagactg       60

tcttgcgccg cctccggctt caccttctcc agcttcggca tgcactgggt ccgccaggct      120

ccaggcaagg gactggaatg ggtggcctac atctcctccg actcctccgc catctactac      180

gccgacaccg tgaagggcag gttcaccatc tcccgggaca acgccaagaa ctccctgtac      240

ctgcagatga actccctgcg gagcgaggac accgccgtgt actactgcgc cagaggccgg      300

gagaatatct actacggctc ccggctggat tattggggcc agggcaccac cgtgaccgtg      360

tcctct                                                                 366


<210>  85
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of chBRCA84D Light Chain

<400>  85

Asp Ile Ala Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Asp Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Asn Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  86
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding chBRCA84D Light Chain

<400>  86
gacattgcga tgacccagtc tcaaaaattc atgtccacat cagtaggaga cagggtcagc       60

gtcacctgca aggccagtca gaatgtggat actaatgtag cctggtatca acagaaacca      120

gggcaatctc ctaaagcact gatttactcg gcatcctacc ggtacagtgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat ttcactctca ccatcaacaa tgtgcagtct      240

gaagacttgg cagagtattt ctgtcagcaa tataacaact atccattcac gttcggctcg      300

gggacaaagt tggaaataaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gttag                      645


<210>  87
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of chBRCA84D Heavy Chain

<400>  87

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Asp Ser Ser Ala Ile Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Gly Arg Gly Arg Glu Asn Ile Tyr Tyr Gly Ser Arg Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  88
<211>  1359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding chBRCA84D Heavy Chain

<400>  88
gatgtgcagc tggtggagtc tgggggaggc ttagtgcagc ctggagggtc ccggaaactc       60

tcctgtgcag cctctggatt cactttcagt agctttggaa tgcactgggt tcgtcaggct      120

ccagagaagg ggctggagtg ggtcgcatac attagtagtg acagtagtgc catctactat      180

gcagacacag tgaagggccg attcaccatc tccagagaca atcccaagaa caccctgttc      240

ctgcaaatga ccagtctaag gtctgaggac acggccatgt attactgtgg aagagggagg      300

gaaaacattt actacggtag taggcttgac tactggggcc aaggcaccac tctcacagtc      360

tcctcagcct ccaccaaggg cccatcggtc ttccccctgg caccctcctc caagagcacc      420

tctgggggca cagcggccct gggctgcctg gtcaaggact acttccccga accggtgacg      480

gtgtcgtgga actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag      540

tcctcaggac tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc      600

cagacctaca tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagagagtt      660

gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg      720

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      780

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      840

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      900

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      960

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc     1020

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     1080

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     1140

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1200

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1260

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1320

tacacgcaga agagcctctc cctgtctccg ggtaaatga                            1359


<210>  89
<211>  191
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(191)
<223>  Amino Acid Sequence of VEGF Isoform 162

<400>  89

Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 
1               5                   10                  15      


Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala Glu Gly 
            20                  25                  30          


Gly Gly Gln Asn His His Glu Val Val Lys Phe Met Asp Val Tyr Gln 
        35                  40                  45              


Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu 
    50                  55                  60                  


Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro Leu 
65                  70                  75                  80  


Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro 
                85                  90                  95      


Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg Ile Lys Pro His 
            100                 105                 110         


Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln His Asn Lys Cys 
        115                 120                 125             


Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu Asn Pro Cys Gly 
    130                 135                 140                 


Pro Cys Ser Glu Arg Arg Lys His Leu Phe Val Gln Asp Pro Gln Thr 
145                 150                 155                 160 


Cys Lys Cys Ser Cys Lys Asn Thr Asp Ser Arg Cys Lys Ala Arg Gln 
                165                 170                 175     


Leu Glu Leu Asn Glu Arg Thr Cys Arg Cys Asp Lys Pro Arg Arg 
            180                 185                 190     


<210>  90
<211>  990
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(990)
<223>  Polynucleotide Encoding the Amino Acid Sequence of VEGF Isoform 
       162

<400>  90
cagtgtgctg gcggcccggc gcgagccggc ccggccccgg tcgggcctcc gaaaccatga       60

actttctgct gtcttgggtg cattggagcc tcgccttgct gctctacctc caccatgcca      120

agtggtccca ggctgcaccc atggcagaag gaggagggca gaatcatcac gaagtggtga      180

agttcatgga tgtctatcag cgcagctact gccatccaat cgagaccctg gtggacatct      240

tccaggagta ccctgatgag atcgagtaca tcttcaagcc atcctgtgtg cccctgatgc      300

gatgcggggg ctgctgcaat gacgagggcc tggagtgtgt gcccactgag gagtccaaca      360

tcaccatgca gattatgcgg atcaaacctc accaaggcca gcacatagga gagatgagct      420

tcctacagca caacaaatgt gaatgcagac caaagaaaga tagagcaaga caagaaaatc      480

cctgtgggcc ttgctcagag cggagaaagc atttgtttgt acaagatccg cagacgtgta      540

aatgttcctg caaaaacaca gactcgcgtt gcaaggcgag gcagcttgag ttaaacgaac      600

gtacttgcag atgtgacaag ccgaggcggt gagccgggca ggaggaagga gcctccctca      660

gggtttcggg aaccagatct ctcaccagga aagactgata cagaacgatc gatacagaaa      720

ccacgctgcc gccaccacac catcaccatc gacagaacag tccttaatcc agaaacctga      780

aatgaaggaa gaggagactc tgcgcagagc actttgggtc cggagggcga gactccggcg      840

gaagcattcc cgggcgggtg acccagcacg gtccctcttg gaattggatt cgccatttta      900

tttttcttgc tgctaaatca ccgagcccgg aagattagag agttttattt ctgggattcc      960

tgtagacaca ccgcggccgc cagcacactg                                       990


<210>  91
<211>  232
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(232)
<223>  Amino Acid Sequence of VEGF Isoform 206

<400>  91

Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 
1               5                   10                  15      


Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala Glu Gly 
            20                  25                  30          


Gly Gly Gln Asn His His Glu Val Val Lys Phe Met Asp Val Tyr Gln 
        35                  40                  45              


Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu 
    50                  55                  60                  


Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro Leu 
65                  70                  75                  80  


Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro 
                85                  90                  95      


Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg Ile Lys Pro His 
            100                 105                 110         


Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln His Asn Lys Cys 
        115                 120                 125             


Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu Lys Lys Ser Val 
    130                 135                 140                 


Arg Gly Lys Gly Lys Gly Gln Lys Arg Lys Arg Lys Lys Ser Arg Tyr 
145                 150                 155                 160 


Lys Ser Trp Ser Val Tyr Val Gly Ala Arg Cys Cys Leu Met Pro Trp 
                165                 170                 175     


Ser Leu Pro Gly Pro His Pro Cys Gly Pro Cys Ser Glu Arg Arg Lys 
            180                 185                 190         


His Leu Phe Val Gln Asp Pro Gln Thr Cys Lys Cys Ser Cys Lys Asn 
        195                 200                 205             


Thr Asp Ser Arg Cys Lys Ala Arg Gln Leu Glu Leu Asn Glu Arg Thr 
    210                 215                 220                 


Cys Arg Cys Asp Lys Pro Arg Arg 
225                 230         


<210>  92
<211>  1338
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1338)
<223>  Amino Acid Sequence of VEGF Receptor VEGFR-1

<400>  92

Met Val Ser Tyr Trp Asp Thr Gly Val Leu Leu Cys Ala Leu Leu Ser 
1               5                   10                  15      


Cys Leu Leu Leu Thr Gly Ser Ser Ser Gly Ser Lys Leu Lys Asp Pro 
            20                  25                  30          


Glu Leu Ser Leu Lys Gly Thr Gln His Ile Met Gln Ala Gly Gln Thr 
        35                  40                  45              


Leu His Leu Gln Cys Arg Gly Glu Ala Ala His Lys Trp Ser Leu Pro 
    50                  55                  60                  


Glu Met Val Ser Lys Glu Ser Glu Arg Leu Ser Ile Thr Lys Ser Ala 
65                  70                  75                  80  


Cys Gly Arg Asn Gly Lys Gln Phe Cys Ser Thr Leu Thr Leu Asn Thr 
                85                  90                  95      


Ala Gln Ala Asn His Thr Gly Phe Tyr Ser Cys Lys Tyr Leu Ala Val 
            100                 105                 110         


Pro Thr Ser Lys Lys Lys Glu Thr Glu Ser Ala Ile Tyr Ile Phe Ile 
        115                 120                 125             


Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu 
    130                 135                 140                 


Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val 
145                 150                 155                 160 


Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr 
                165                 170                 175     


Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe 
            180                 185                 190         


Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu 
        195                 200                 205             


Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg 
    210                 215                 220                 


Gln Thr Asn Thr Ile Ile Asp Val Gln Ile Ser Thr Pro Arg Pro Val 
225                 230                 235                 240 


Lys Leu Leu Arg Gly His Thr Leu Val Leu Asn Cys Thr Ala Thr Thr 
                245                 250                 255     


Pro Leu Asn Thr Arg Val Gln Met Thr Trp Ser Tyr Pro Asp Glu Lys 
            260                 265                 270         


Asn Lys Arg Ala Ser Val Arg Arg Arg Ile Asp Gln Ser Asn Ser His 
        275                 280                 285             


Ala Asn Ile Phe Tyr Ser Val Leu Thr Ile Asp Lys Met Gln Asn Lys 
    290                 295                 300                 


Asp Lys Gly Leu Tyr Thr Cys Arg Val Arg Ser Gly Pro Ser Phe Lys 
305                 310                 315                 320 


Ser Val Asn Thr Ser Val His Ile Tyr Asp Lys Ala Phe Ile Thr Val 
                325                 330                 335     


Lys His Arg Lys Gln Gln Val Leu Glu Thr Val Ala Gly Lys Arg Ser 
            340                 345                 350         


Tyr Arg Leu Ser Met Lys Val Lys Ala Phe Pro Ser Pro Glu Val Val 
        355                 360                 365             


Trp Leu Lys Asp Gly Leu Pro Ala Thr Glu Lys Ser Ala Arg Tyr Leu 
    370                 375                 380                 


Thr Arg Gly Tyr Ser Leu Ile Ile Lys Asp Val Thr Glu Glu Asp Ala 
385                 390                 395                 400 


Gly Asn Tyr Thr Ile Leu Leu Ser Ile Lys Gln Ser Asn Val Phe Lys 
                405                 410                 415     


Asn Leu Thr Ala Thr Leu Ile Val Asn Val Lys Pro Gln Ile Tyr Glu 
            420                 425                 430         


Lys Ala Val Ser Ser Phe Pro Asp Pro Ala Leu Tyr Pro Leu Gly Ser 
        435                 440                 445             


Arg Gln Ile Leu Thr Cys Thr Ala Tyr Gly Ile Pro Gln Pro Thr Ile 
    450                 455                 460                 


Lys Trp Phe Trp His Pro Cys Asn His Asn His Ser Glu Ala Arg Cys 
465                 470                 475                 480 


Asp Phe Cys Ser Asn Asn Glu Glu Ser Phe Ile Leu Asp Ala Asp Ser 
                485                 490                 495     


Asn Met Gly Asn Arg Ile Glu Ser Ile Thr Gln Arg Met Ala Ile Ile 
            500                 505                 510         


Glu Gly Lys Asn Lys Met Ala Ser Thr Leu Val Val Ala Asp Ser Arg 
        515                 520                 525             


Ile Ser Gly Ile Tyr Ile Cys Ile Ala Ser Asn Lys Val Gly Thr Val 
    530                 535                 540                 


Gly Arg Asn Ile Ser Phe Tyr Ile Thr Asp Val Pro Asn Gly Phe His 
545                 550                 555                 560 


Val Asn Leu Glu Lys Met Pro Thr Glu Gly Glu Asp Leu Lys Leu Ser 
                565                 570                 575     


Cys Thr Val Asn Lys Phe Leu Tyr Arg Asp Val Thr Trp Ile Leu Leu 
            580                 585                 590         


Arg Thr Val Asn Asn Arg Thr Met His Tyr Ser Ile Ser Lys Gln Lys 
        595                 600                 605             


Met Ala Ile Thr Lys Glu His Ser Ile Thr Leu Asn Leu Thr Ile Met 
    610                 615                 620                 


Asn Val Ser Leu Gln Asp Ser Gly Thr Tyr Ala Cys Arg Ala Arg Asn 
625                 630                 635                 640 


Val Tyr Thr Gly Glu Glu Ile Leu Gln Lys Lys Glu Ile Thr Ile Arg 
                645                 650                 655     


Asp Gln Glu Ala Pro Tyr Leu Leu Arg Asn Leu Ser Asp His Thr Val 
            660                 665                 670         


Ala Ile Ser Ser Ser Thr Thr Leu Asp Cys His Ala Asn Gly Val Pro 
        675                 680                 685             


Glu Pro Gln Ile Thr Trp Phe Lys Asn Asn His Lys Ile Gln Gln Glu 
    690                 695                 700                 


Pro Gly Ile Ile Leu Gly Pro Gly Ser Ser Thr Leu Phe Ile Glu Arg 
705                 710                 715                 720 


Val Thr Glu Glu Asp Glu Gly Val Tyr His Cys Lys Ala Thr Asn Gln 
                725                 730                 735     


Lys Gly Ser Val Glu Ser Ser Ala Tyr Leu Thr Val Gln Gly Thr Ser 
            740                 745                 750         


Asp Lys Ser Asn Leu Glu Leu Ile Thr Leu Thr Cys Thr Cys Val Ala 
        755                 760                 765             


Ala Thr Leu Phe Trp Leu Leu Leu Thr Leu Phe Ile Arg Lys Met Lys 
    770                 775                 780                 


Arg Ser Ser Ser Glu Ile Lys Thr Asp Tyr Leu Ser Ile Ile Met Asp 
785                 790                 795                 800 


Pro Asp Glu Val Pro Leu Asp Glu Gln Cys Glu Arg Leu Pro Tyr Asp 
                805                 810                 815     


Ala Ser Lys Trp Glu Phe Ala Arg Glu Arg Leu Lys Leu Gly Lys Ser 
            820                 825                 830         


Leu Gly Arg Gly Ala Phe Gly Lys Val Val Gln Ala Ser Ala Phe Gly 
        835                 840                 845             


Ile Lys Lys Ser Pro Thr Cys Arg Thr Val Ala Val Lys Met Leu Lys 
    850                 855                 860                 


Glu Gly Ala Thr Ala Ser Glu Tyr Lys Ala Leu Met Thr Glu Leu Lys 
865                 870                 875                 880 


Ile Leu Thr His Ile Gly His His Leu Asn Val Val Asn Leu Leu Gly 
                885                 890                 895     


Ala Cys Thr Lys Gln Gly Gly Pro Leu Met Val Ile Val Glu Tyr Cys 
            900                 905                 910         


Lys Tyr Gly Asn Leu Ser Asn Tyr Leu Lys Ser Lys Arg Asp Leu Phe 
        915                 920                 925             


Phe Leu Asn Lys Asp Ala Ala Leu His Met Glu Pro Lys Lys Glu Lys 
    930                 935                 940                 


Met Glu Pro Gly Leu Glu Gln Gly Lys Lys Pro Arg Leu Asp Ser Val 
945                 950                 955                 960 


Thr Ser Ser Glu Ser Phe Ala Ser Ser Gly Phe Gln Glu Asp Lys Ser 
                965                 970                 975     


Leu Ser Asp Val Glu Glu Glu Glu Asp Ser Asp Gly Phe Tyr Lys Glu 
            980                 985                 990         


Pro Ile Thr Met Glu Asp Leu Ile  Ser Tyr Ser Phe Gln  Val Ala Arg 
        995                 1000                 1005             


Gly Met  Glu Phe Leu Ser Ser  Arg Lys Cys Ile His  Arg Asp Leu 
    1010                 1015                 1020             


Ala Ala  Arg Asn Ile Leu Leu  Ser Glu Asn Asn Val  Val Lys Ile 
    1025                 1030                 1035             


Cys Asp  Phe Gly Leu Ala Arg  Asp Ile Tyr Lys Asn  Pro Asp Tyr 
    1040                 1045                 1050             


Val Arg  Lys Gly Asp Thr Arg  Leu Pro Leu Lys Trp  Met Ala Pro 
    1055                 1060                 1065             


Glu Ser  Ile Phe Asp Lys Ile  Tyr Ser Thr Lys Ser  Asp Val Trp 
    1070                 1075                 1080             


Ser Tyr  Gly Val Leu Leu Trp  Glu Ile Phe Ser Leu  Gly Gly Ser 
    1085                 1090                 1095             


Pro Tyr  Pro Gly Val Gln Met  Asp Glu Asp Phe Cys  Ser Arg Leu 
    1100                 1105                 1110             


Arg Glu  Gly Met Arg Met Arg  Ala Pro Glu Tyr Ser  Thr Pro Glu 
    1115                 1120                 1125             


Ile Tyr  Gln Ile Met Leu Asp  Cys Trp His Arg Asp  Pro Lys Glu 
    1130                 1135                 1140             


Arg Pro  Arg Phe Ala Glu Leu  Val Glu Lys Leu Gly  Asp Leu Leu 
    1145                 1150                 1155             


Gln Ala  Asn Val Gln Gln Asp  Gly Lys Asp Tyr Ile  Pro Ile Asn 
    1160                 1165                 1170             


Ala Ile  Leu Thr Gly Asn Ser  Gly Phe Thr Tyr Ser  Thr Pro Ala 
    1175                 1180                 1185             


Phe Ser  Glu Asp Phe Phe Lys  Glu Ser Ile Ser Ala  Pro Lys Phe 
    1190                 1195                 1200             


Asn Ser  Gly Ser Ser Asp Asp  Val Arg Tyr Val Asn  Ala Phe Lys 
    1205                 1210                 1215             


Phe Met  Ser Leu Glu Arg Ile  Lys Thr Phe Glu Glu  Leu Leu Pro 
    1220                 1225                 1230             


Asn Ala  Thr Ser Met Phe Asp  Asp Tyr Gln Gly Asp  Ser Ser Thr 
    1235                 1240                 1245             


Leu Leu  Ala Ser Pro Met Leu  Lys Arg Phe Thr Trp  Thr Asp Ser 
    1250                 1255                 1260             


Lys Pro  Lys Ala Ser Leu Lys  Ile Asp Leu Arg Val  Thr Ser Lys 
    1265                 1270                 1275             


Ser Lys  Glu Ser Gly Leu Ser  Asp Val Ser Arg Pro  Ser Phe Cys 
    1280                 1285                 1290             


His Ser  Ser Cys Gly His Val  Ser Glu Gly Lys Arg  Arg Phe Thr 
    1295                 1300                 1305             


Tyr Asp  His Ala Glu Leu Glu  Arg Lys Ile Ala Cys  Cys Ser Pro 
    1310                 1315                 1320             


Pro Pro  Asp Tyr Asn Ser Val  Val Leu Tyr Ser Thr  Pro Pro Ile 
    1325                 1330                 1335             


<210>  93
<211>  1356
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1356)
<223>  Amino Acid Sequence of VEGF Receptor VEGFR-2

<400>  93

Met Gln Ser Lys Val Leu Leu Ala Val Ala Leu Trp Leu Cys Val Glu 
1               5                   10                  15      


Thr Arg Ala Ala Ser Val Gly Leu Pro Ser Val Ser Leu Asp Leu Pro 
            20                  25                  30          


Arg Leu Ser Ile Gln Lys Asp Ile Leu Thr Ile Lys Ala Asn Thr Thr 
        35                  40                  45              


Leu Gln Ile Thr Cys Arg Gly Gln Arg Asp Leu Asp Trp Leu Trp Pro 
    50                  55                  60                  


Asn Asn Gln Ser Gly Ser Glu Gln Arg Val Glu Val Thr Glu Cys Ser 
65                  70                  75                  80  


Asp Gly Leu Phe Cys Lys Thr Leu Thr Ile Pro Lys Val Ile Gly Asn 
                85                  90                  95      


Asp Thr Gly Ala Tyr Lys Cys Phe Tyr Arg Glu Thr Asp Leu Ala Ser 
            100                 105                 110         


Val Ile Tyr Val Tyr Val Gln Asp Tyr Arg Ser Pro Phe Ile Ala Ser 
        115                 120                 125             


Val Ser Asp Gln His Gly Val Val Tyr Ile Thr Glu Asn Lys Asn Lys 
    130                 135                 140                 


Thr Val Val Ile Pro Cys Leu Gly Ser Ile Ser Asn Leu Asn Val Ser 
145                 150                 155                 160 


Leu Cys Ala Arg Tyr Pro Glu Lys Arg Phe Val Pro Asp Gly Asn Arg 
                165                 170                 175     


Ile Ser Trp Asp Ser Lys Lys Gly Phe Thr Ile Pro Ser Tyr Met Ile 
            180                 185                 190         


Ser Tyr Ala Gly Met Val Phe Cys Glu Ala Lys Ile Asn Asp Glu Ser 
        195                 200                 205             


Tyr Gln Ser Ile Met Tyr Ile Val Val Val Val Gly Tyr Arg Ile Tyr 
    210                 215                 220                 


Asp Val Val Leu Ser Pro Ser His Gly Ile Glu Leu Ser Val Gly Glu 
225                 230                 235                 240 


Lys Leu Val Leu Asn Cys Thr Ala Arg Thr Glu Leu Asn Val Gly Ile 
                245                 250                 255     


Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys His Gln His Lys Lys Leu 
            260                 265                 270         


Val Asn Arg Asp Leu Lys Thr Gln Ser Gly Ser Glu Met Lys Lys Phe 
        275                 280                 285             


Leu Ser Thr Leu Thr Ile Asp Gly Val Thr Arg Ser Asp Gln Gly Leu 
    290                 295                 300                 


Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met Thr Lys Lys Asn Ser Thr 
305                 310                 315                 320 


Phe Val Arg Val His Glu Lys Pro Phe Val Ala Phe Gly Ser Gly Met 
                325                 330                 335     


Glu Ser Leu Val Glu Ala Thr Val Gly Glu Arg Val Arg Ile Pro Ala 
            340                 345                 350         


Lys Tyr Leu Gly Tyr Pro Pro Pro Glu Ile Lys Trp Tyr Lys Asn Gly 
        355                 360                 365             


Ile Pro Leu Glu Ser Asn His Thr Ile Lys Ala Gly His Val Leu Thr 
    370                 375                 380                 


Ile Met Glu Val Ser Glu Arg Asp Thr Gly Asn Tyr Thr Val Ile Leu 
385                 390                 395                 400 


Thr Asn Pro Ile Ser Lys Glu Lys Gln Ser His Val Val Ser Leu Val 
                405                 410                 415     


Val Tyr Val Pro Pro Gln Ile Gly Glu Lys Ser Leu Ile Ser Pro Val 
            420                 425                 430         


Asp Ser Tyr Gln Tyr Gly Thr Thr Gln Thr Leu Thr Cys Thr Val Tyr 
        435                 440                 445             


Ala Ile Pro Pro Pro His His Ile His Trp Tyr Trp Gln Leu Glu Glu 
    450                 455                 460                 


Glu Cys Ala Asn Glu Pro Ser Gln Ala Val Ser Val Thr Asn Pro Tyr 
465                 470                 475                 480 


Pro Cys Glu Glu Trp Arg Ser Val Glu Asp Phe Gln Gly Gly Asn Lys 
                485                 490                 495     


Ile Glu Val Asn Lys Asn Gln Phe Ala Leu Ile Glu Gly Lys Asn Lys 
            500                 505                 510         


Thr Val Ser Thr Leu Val Ile Gln Ala Ala Asn Val Ser Ala Leu Tyr 
        515                 520                 525             


Lys Cys Glu Ala Val Asn Lys Val Gly Arg Gly Glu Arg Val Ile Ser 
    530                 535                 540                 


Phe His Val Thr Arg Gly Pro Glu Ile Thr Leu Gln Pro Asp Met Gln 
545                 550                 555                 560 


Pro Thr Glu Gln Glu Ser Val Ser Leu Trp Cys Thr Ala Asp Arg Ser 
                565                 570                 575     


Thr Phe Glu Asn Leu Thr Trp Tyr Lys Leu Gly Pro Gln Pro Leu Pro 
            580                 585                 590         


Ile His Val Gly Glu Leu Pro Thr Pro Val Cys Lys Asn Leu Asp Thr 
        595                 600                 605             


Leu Trp Lys Leu Asn Ala Thr Met Phe Ser Asn Ser Thr Asn Asp Ile 
    610                 615                 620                 


Leu Ile Met Glu Leu Lys Asn Ala Ser Leu Gln Asp Gln Gly Asp Tyr 
625                 630                 635                 640 


Val Cys Leu Ala Gln Asp Arg Lys Thr Lys Lys Arg His Cys Val Val 
                645                 650                 655     


Arg Gln Leu Thr Val Leu Glu Arg Val Ala Pro Thr Ile Thr Gly Asn 
            660                 665                 670         


Leu Glu Asn Gln Thr Thr Ser Ile Gly Glu Ser Ile Glu Val Ser Cys 
        675                 680                 685             


Thr Ala Ser Gly Asn Pro Pro Pro Gln Ile Met Trp Phe Lys Asp Asn 
    690                 695                 700                 


Glu Thr Leu Val Glu Asp Ser Gly Ile Val Leu Lys Asp Gly Asn Arg 
705                 710                 715                 720 


Asn Leu Thr Ile Arg Arg Val Arg Lys Glu Asp Glu Gly Leu Tyr Thr 
                725                 730                 735     


Cys Gln Ala Cys Ser Val Leu Gly Cys Ala Lys Val Glu Ala Phe Phe 
            740                 745                 750         


Ile Ile Glu Gly Ala Gln Glu Lys Thr Asn Leu Glu Ile Ile Ile Leu 
        755                 760                 765             


Val Gly Thr Ala Val Ile Ala Met Phe Phe Trp Leu Leu Leu Val Ile 
    770                 775                 780                 


Ile Leu Arg Thr Val Lys Arg Ala Asn Gly Gly Glu Leu Lys Thr Gly 
785                 790                 795                 800 


Tyr Leu Ser Ile Val Met Asp Pro Asp Glu Leu Pro Leu Asp Glu His 
                805                 810                 815     


Cys Glu Arg Leu Pro Tyr Asp Ala Ser Lys Trp Glu Phe Pro Arg Asp 
            820                 825                 830         


Arg Leu Lys Leu Gly Lys Pro Leu Gly Arg Gly Ala Phe Gly Gln Val 
        835                 840                 845             


Ile Glu Ala Asp Ala Phe Gly Ile Asp Lys Thr Ala Thr Cys Arg Thr 
    850                 855                 860                 


Val Ala Val Lys Met Leu Lys Glu Gly Ala Thr His Ser Glu His Arg 
865                 870                 875                 880 


Ala Leu Met Ser Glu Leu Lys Ile Leu Ile His Ile Gly His His Leu 
                885                 890                 895     


Asn Val Val Asn Leu Leu Gly Ala Cys Thr Lys Pro Gly Gly Pro Leu 
            900                 905                 910         


Met Val Ile Val Glu Phe Cys Lys Phe Gly Asn Leu Ser Thr Tyr Leu 
        915                 920                 925             


Arg Ser Lys Arg Asn Glu Phe Val Pro Tyr Lys Thr Lys Gly Ala Arg 
    930                 935                 940                 


Phe Arg Gln Gly Lys Asp Tyr Val Gly Ala Ile Pro Val Asp Leu Lys 
945                 950                 955                 960 


Arg Arg Leu Asp Ser Ile Thr Ser Ser Gln Ser Ser Ala Ser Ser Gly 
                965                 970                 975     


Phe Val Glu Glu Lys Ser Leu Ser Asp Val Glu Glu Glu Glu Ala Pro 
            980                 985                 990         


Glu Asp Leu Tyr Lys Asp Phe Leu  Thr Leu Glu His Leu  Ile Cys Tyr 
        995                 1000                 1005             


Ser Phe  Gln Val Ala Lys Gly  Met Glu Phe Leu Ala  Ser Arg Lys 
    1010                 1015                 1020             


Cys Ile  His Arg Asp Leu Ala  Ala Arg Asn Ile Leu  Leu Ser Glu 
    1025                 1030                 1035             


Lys Asn  Val Val Lys Ile Cys  Asp Phe Gly Leu Ala  Arg Asp Ile 
    1040                 1045                 1050             


Tyr Lys  Asp Pro Asp Tyr Val  Arg Lys Gly Asp Ala  Arg Leu Pro 
    1055                 1060                 1065             


Leu Lys  Trp Met Ala Pro Glu  Thr Ile Phe Asp Arg  Val Tyr Thr 
    1070                 1075                 1080             


Ile Gln  Ser Asp Val Trp Ser  Phe Gly Val Leu Leu  Trp Glu Ile 
    1085                 1090                 1095             


Phe Ser  Leu Gly Ala Ser Pro  Tyr Pro Gly Val Lys  Ile Asp Glu 
    1100                 1105                 1110             


Glu Phe  Cys Arg Arg Leu Lys  Glu Gly Thr Arg Met  Arg Ala Pro 
    1115                 1120                 1125             


Asp Tyr  Thr Thr Pro Glu Met  Tyr Gln Thr Met Leu  Asp Cys Trp 
    1130                 1135                 1140             


His Gly  Glu Pro Ser Gln Arg  Pro Thr Phe Ser Glu  Leu Val Glu 
    1145                 1150                 1155             


His Leu  Gly Asn Leu Leu Gln  Ala Asn Ala Gln Gln  Asp Gly Lys 
    1160                 1165                 1170             


Asp Tyr  Ile Val Leu Pro Ile  Ser Glu Thr Leu Ser  Met Glu Glu 
    1175                 1180                 1185             


Asp Ser  Gly Leu Ser Leu Pro  Thr Ser Pro Val Ser  Cys Met Glu 
    1190                 1195                 1200             


Glu Glu  Glu Val Cys Asp Pro  Lys Phe His Tyr Asp  Asn Thr Ala 
    1205                 1210                 1215             


Gly Ile  Ser Gln Tyr Leu Gln  Asn Ser Lys Arg Lys  Ser Arg Pro 
    1220                 1225                 1230             


Val Ser  Val Lys Thr Phe Glu  Asp Ile Pro Leu Glu  Glu Pro Glu 
    1235                 1240                 1245             


Val Lys  Val Ile Pro Asp Asp  Asn Gln Thr Asp Ser  Gly Met Val 
    1250                 1255                 1260             


Leu Ala  Ser Glu Glu Leu Lys  Thr Leu Glu Asp Arg  Thr Lys Leu 
    1265                 1270                 1275             


Ser Pro  Ser Phe Gly Gly Met  Val Pro Ser Lys Ser  Arg Glu Ser 
    1280                 1285                 1290             


Val Ala  Ser Glu Gly Ser Asn  Gln Thr Ser Gly Tyr  Gln Ser Gly 
    1295                 1300                 1305             


Tyr His  Ser Asp Asp Thr Asp  Thr Thr Val Tyr Ser  Ser Glu Glu 
    1310                 1315                 1320             


Ala Glu  Leu Leu Lys Leu Ile  Glu Ile Gly Val Gln  Thr Gly Ser 
    1325                 1330                 1335             


Thr Ala  Gln Ile Leu Gln Pro  Asp Ser Gly Thr Thr  Leu Ser Ser 
    1340                 1345                 1350             


Pro Pro  Val 
    1355     


<210>  94
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of the Light Chain of Bevacizumab

<400>  94

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Phe Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Thr Val Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Glu Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  95
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of the Heavy Chain of Bevacizumab

<400>  95

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Ala Asp Phe 
    50                  55                  60                  


Lys Arg Arg Phe Thr Phe Ser Leu Asp Thr Ser Lys Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Tyr Pro His Tyr Tyr Gly Ser Ser His Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  96
<211>  218
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(218)
<223>  Amino Acid Sequence of the IgG1 Fc Region

<400>  96

Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        35                  40                  45              


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    50                  55                  60                  


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
65                  70                  75                  80  


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                85                  90                  95      


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            100                 105                 110         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    130                 135                 140                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
145                 150                 155                 160 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                165                 170                 175     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            180                 185                 190         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        195                 200                 205             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215             


<210>  97
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Preferred Linker of VL and VH Diabody Domains

<400>  97

Gly Gly Gly Ser Gly Gly Gly Gly 
1               5               


<210>  98
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding Preferred Linker of VL and VH Diabody 
       Domains

<400>  98
ggaggcggat ccggaggcgg aggc                                              24


<210>  99
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cysteine-Containing Linker

<400>  99

Leu Gly Gly Cys 
1               


<210>  100
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of Hinge Domain Linker

<400>  100

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
1               5                   10              


<210>  101
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of Hinge Domain Linker

<400>  101

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser 
1               5                   10  


<210>  102
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cysteine-Containing, Heterodimer-Promoting Linker Derived from 
       IgG Hinge Domain

<400>  102

Val Glu Pro Lys Ser Cys 
1               5       


<210>  103
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding Cysteine-Containing, 
       Heterodimer-Promoting Linker Derived from IgG Hinge Domain

<400>  103
gttgagccca aatcttgt                                                     18


<210>  104
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cysteine-Containing, Heterodimer-Promoting Linker Derived from 
       Human Kappa Light Chain Domain

<400>  104

Leu Gly Gly Cys Phe Asn Arg Gly Glu Cys 
1               5                   10  


<210>  105
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding Cysteine-Containing, 
       Heterodimer-Promoting Linker Derived from Human Kappa Light Chain
       Domain

<400>  105
ctgggaggct gcttcaacag gggagagtgt                                        30


<210>  106
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cysteine-Containing, Heterodimer-Promoting Linker Derived from 
       Human Kappa Light Chain Domain

<400>  106

Phe Asn Arg Gly Glu Cys 
1               5       


<210>  107
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding Cysteine-Containing, 
       Heterodimer-Promoting Linker Derived from Human Kappa Light Chain
       Domain

<400>  107
ttcaacaggg gagagtgt                                                     18


<210>  108
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of E-coil Heterodimer-Promoting Domain

<400>  108

Glu Val Ala Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys Glu Val 
1               5                   10                  15      


Ala Ala Leu Glu Lys Glu Val Ala Ala Leu Glu Lys 
            20                  25              


<210>  109
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of K-coil Heterodimer-Promoting Domain

<400>  109

Lys Val Ala Ala Leu Lys Glu Lys Val Ala Ala Leu Lys Glu Lys Val 
1               5                   10                  15      


Ala Ala Leu Lys Glu Lys Val Ala Ala Leu Lys Glu 
            20                  25              


<210>  110
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of Linker

<400>  110

Gly Gly Gly Asn Ser 
1               5   


