                         SEQUENCE LISTING

<110>  Inserm
 
<120>  METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF 
       CANCER

<130>  BIO13321-POYET

<160>  17    

<170>  PatentIn version 3.3

<210>  1
<211>  524
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Pro Thr Val Glu Glu Leu Tyr Arg Asn Tyr Gly Ile Leu Ala Asp 
1               5                   10                  15      


Ala Thr Glu Gln Val Gly Gln His Lys Asp Ala Tyr Gln Val Ile Leu 
            20                  25                  30          


Asp Gly Val Lys Gly Gly Thr Lys Glu Lys Arg Leu Ala Ala Gln Phe 
        35                  40                  45              


Ile Pro Lys Phe Phe Lys His Phe Pro Glu Leu Ala Asp Ser Ala Ile 
    50                  55                  60                  


Asn Ala Gln Leu Asp Leu Cys Glu Asp Glu Asp Val Ser Ile Arg Arg 
65                  70                  75                  80  


Gln Ala Ile Lys Glu Leu Pro Gln Phe Ala Thr Gly Glu Asn Leu Pro 
                85                  90                  95      


Arg Val Ala Asp Ile Leu Thr Gln Leu Leu Gln Thr Asp Asp Ser Ala 
            100                 105                 110         


Glu Phe Asn Leu Val Asn Asn Ala Leu Leu Ser Ile Phe Lys Met Asp 
        115                 120                 125             


Ala Lys Gly Thr Leu Gly Gly Leu Phe Ser Gln Ile Leu Gln Gly Glu 
    130                 135                 140                 


Asp Ile Val Arg Glu Arg Ala Ile Lys Phe Leu Ser Thr Lys Leu Lys 
145                 150                 155                 160 


Thr Leu Pro Asp Glu Val Leu Thr Lys Glu Val Glu Glu Leu Ile Leu 
                165                 170                 175     


Thr Glu Ser Lys Lys Val Leu Glu Asp Val Thr Gly Glu Glu Phe Val 
            180                 185                 190         


Leu Phe Met Lys Ile Leu Ser Gly Leu Lys Ser Leu Gln Thr Val Ser 
        195                 200                 205             


Gly Arg Gln Gln Leu Val Glu Leu Val Ala Glu Gln Ala Asp Leu Glu 
    210                 215                 220                 


Gln Thr Phe Asn Pro Ser Asp Pro Asp Cys Val Asp Arg Leu Leu Gln 
225                 230                 235                 240 


Cys Thr Arg Gln Ala Val Pro Leu Phe Ser Lys Asn Val His Ser Thr 
                245                 250                 255     


Arg Phe Val Thr Tyr Phe Cys Glu Gln Val Leu Pro Asn Leu Gly Thr 
            260                 265                 270         


Leu Thr Thr Pro Val Glu Gly Leu Asp Ile Gln Leu Glu Val Leu Lys 
        275                 280                 285             


Leu Leu Ala Glu Met Ser Ser Phe Cys Gly Asp Met Glu Lys Leu Glu 
    290                 295                 300                 


Thr Asn Leu Arg Lys Leu Phe Asp Lys Leu Leu Glu Tyr Met Pro Leu 
305                 310                 315                 320 


Pro Pro Glu Glu Ala Glu Asn Gly Glu Asn Ala Gly Asn Glu Glu Pro 
                325                 330                 335     


Lys Leu Gln Phe Ser Tyr Val Glu Cys Leu Leu Tyr Ser Phe His Gln 
            340                 345                 350         


Leu Gly Arg Lys Leu Pro Asp Phe Leu Thr Ala Lys Leu Asn Ala Glu 
        355                 360                 365             


Lys Leu Lys Asp Phe Lys Ile Arg Leu Gln Tyr Phe Ala Arg Gly Leu 
    370                 375                 380                 


Gln Val Tyr Ile Arg Gln Leu Arg Leu Ala Leu Gln Gly Lys Thr Gly 
385                 390                 395                 400 


Glu Ala Leu Lys Thr Glu Glu Asn Lys Ile Lys Val Val Ala Leu Lys 
                405                 410                 415     


Ile Thr Asn Asn Ile Asn Val Leu Ile Lys Asp Leu Phe His Ile Pro 
            420                 425                 430         


Pro Ser Tyr Lys Ser Thr Val Thr Leu Ser Trp Lys Pro Val Gln Lys 
        435                 440                 445             


Val Glu Ile Gly Gln Lys Arg Ala Ser Glu Asp Thr Thr Ser Gly Ser 
    450                 455                 460                 


Pro Pro Lys Lys Ser Ser Ala Gly Pro Lys Arg Asp Ala Arg Gln Ile 
465                 470                 475                 480 


Tyr Asn Pro Pro Ser Gly Lys Tyr Ser Ser Asn Leu Gly Asn Phe Asn 
                485                 490                 495     


Tyr Glu Gln Arg Gly Ala Phe Arg Gly Ser Arg Gly Gly Arg Gly Trp 
            500                 505                 510         


Gly Thr Arg Gly Asn Arg Ser Arg Gly Arg Leu Tyr 
        515                 520                 


<210>  2
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Penetratin

<400>  2

Arg Gln Ile Lys Ile Trp Phe Lys Lys Gln Asn Arg Arg Met Lys Trp 
1               5                   10                  15      


Lys Lys 
        


<210>  3
<211>  37
<212>  PRT
<213>  Artificial

<220>
<223>  AAC-11-LZ (363-399)

<400>  3

Ala Lys Leu Asn Ala Glu Lys Leu Lys Asp Phe Lys Ile Arg Leu Gln 
1               5                   10                  15      


Tyr Phe Ala Arg Gly Leu Gln Val Tyr Ile Arg Gln Leu Arg Leu Ala 
            20                  25                  30          


Leu Gln Gly Lys Thr 
        35          


<210>  4
<211>  55
<212>  PRT
<213>  Artificial

<220>
<223>  Antp-AAC-11-LZ (363-399)

<400>  4

Arg Gln Ile Lys Ile Trp Phe Lys Lys Gln Asn Arg Arg Met Lys Trp 
1               5                   10                  15      


Lys Lys Ala Lys Leu Asn Ala Glu Lys Leu Lys Asp Phe Lys Ile Arg 
            20                  25                  30          


Leu Gln Tyr Phe Ala Arg Gly Leu Gln Val Tyr Ile Arg Gln Leu Arg 
        35                  40                  45              


Leu Ala Leu Gln Gly Lys Thr 
    50                  55  


<210>  5
<211>  55
<212>  PRT
<213>  Artificial

<220>
<223>  Antp-AAC-11-LZ (363-399)L/G

<400>  5

Arg Gln Ile Lys Ile Trp Phe Lys Lys Gln Asn Arg Arg Met Lys Trp 
1               5                   10                  15      


Lys Lys Ala Lys Leu Asn Ala Glu Lys Leu Lys Asp Phe Lys Ile Arg 
            20                  25                  30          


Gly Gln Tyr Phe Ala Arg Gly Gly Gln Val Tyr Ile Arg Gln Gly Arg 
        35                  40                  45              


Leu Ala Leu Gln Gly Lys Thr 
    50                  55  


<210>  6
<211>  47
<212>  PRT
<213>  Artificial

<220>
<223>  Antp-AAC-11-LZ (371-399)

<400>  6

Arg Gln Ile Lys Ile Trp Phe Lys Lys Gln Asn Arg Arg Met Lys Trp 
1               5                   10                  15      


Lys Lys Lys Asp Phe Lys Ile Arg Leu Gln Tyr Phe Ala Arg Gly Leu 
            20                  25                  30          


Gln Val Tyr Ile Arg Gln Leu Arg Leu Ala Leu Gln Gly Lys Thr 
        35                  40                  45          


<210>  7
<211>  45
<212>  PRT
<213>  Artificial

<220>
<223>  Antp-AAC-11-LZ (371-397)

<400>  7

Arg Gln Ile Lys Ile Trp Phe Lys Lys Gln Asn Arg Arg Met Lys Trp 
1               5                   10                  15      


Lys Lys Lys Asp Phe Lys Ile Arg Leu Gln Tyr Phe Ala Arg Gly Leu 
            20                  25                  30          


Gln Val Tyr Ile Arg Gln Leu Arg Leu Ala Leu Gln Gly 
        35                  40                  45  


<210>  8
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  Antp-AAC-11-LZ (371-391)

<400>  8

Arg Gln Ile Lys Ile Trp Phe Lys Lys Gln Asn Arg Arg Met Lys Trp 
1               5                   10                  15      


Lys Lys Lys Asp Phe Lys Ile Arg Leu Gln Tyr Phe Ala Arg Gly Leu 
            20                  25                  30          


Gln Val Tyr Ile Arg Gln Leu 
        35                  


<210>  9
<211>  41
<212>  PRT
<213>  Artificial

<220>
<223>  Antp-AAC-11-LZ (377-399)

<400>  9

Arg Gln Ile Lys Ile Trp Phe Lys Lys Gln Asn Arg Arg Met Lys Trp 
1               5                   10                  15      


Lys Lys Leu Gln Tyr Phe Ala Arg Gly Leu Gln Val Tyr Ile Arg Gln 
            20                  25                  30          


Leu Arg Leu Ala Leu Gln Gly Lys Thr 
        35                  40      


<210>  10
<211>  38
<212>  PRT
<213>  Artificial

<220>
<223>  Antp-AAC-11-LZ (380-399)

<400>  10

Arg Gln Ile Lys Ile Trp Phe Lys Lys Gln Asn Arg Arg Met Lys Trp 
1               5                   10                  15      


Lys Lys Phe Ala Arg Gly Leu Gln Val Tyr Ile Arg Gln Leu Arg Leu 
            20                  25                  30          


Ala Leu Gln Gly Lys Thr 
        35              


<210>  11
<211>  55
<212>  PRT
<213>  Artificial

<220>
<223>  Cter-Antp-AAC-11-LZ (363-399)

<400>  11

Ala Lys Leu Asn Ala Glu Lys Leu Lys Asp Phe Lys Ile Arg Leu Gln 
1               5                   10                  15      


Tyr Phe Ala Arg Gly Leu Gln Val Tyr Ile Arg Gln Leu Arg Leu Ala 
            20                  25                  30          


Leu Gln Gly Lys Thr Arg Gln Ile Lys Ile Trp Phe Lys Lys Gln Asn 
        35                  40                  45              


Arg Arg Met Lys Trp Lys Lys 
    50                  55  


<210>  12
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  TAT alone

<400>  12

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  13
<211>  51
<212>  PRT
<213>  Artificial

<220>
<223>  TAT-AAC-11-LZ (363-399)

<400>  13

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Gly Gly Ala Lys 
1               5                   10                  15      


Leu Asn Ala Glu Lys Leu Lys Asp Phe Lys Ile Arg Leu Gln Tyr Phe 
            20                  25                  30          


Ala Arg Gly Leu Gln Val Tyr Ile Arg Gln Leu Arg Leu Ala Leu Gln 
        35                  40                  45              


Gly Lys Thr 
    50      


<210>  14
<211>  49
<212>  PRT
<213>  Artificial

<220>
<223>  TAT-AAC-11-LZ (363-399)RI  (D-amino acids)

<400>  14

Arg Arg Arg Gln Arg Arg Lys Lys Arg Gly Tyr Gly Thr Lys Gly Gln 
1               5                   10                  15      


Leu Ala Leu Arg Leu Gln Arg Ile Tyr Val Gln Leu Gly Arg Ala Phe 
            20                  25                  30          


Tyr Gln Leu Arg Ile Lys Phe Asp Lys Leu Lys Glu Ala Asn Leu Lys 
        35                  40                  45              


Ala 
    


<210>  15
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  TAT (47-57) (RI)

<400>  15

Arg Arg Arg Gln Arg Arg Lys Lys Arg Gly Tyr 
1               5                   10      


<210>  16
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  AAC-11-LZ (377-399)

<400>  16

Leu Gln Tyr Phe Ala Arg Gly Leu Gln Val Tyr Ile Arg Gln Leu Arg 
1               5                   10                  15      


Leu Ala Leu Gln Gly Lys Thr 
            20              


<210>  17
<211>  35
<212>  PRT
<213>  Artificial

<220>
<223>  Antp-AAC-11-LZ (377-399 ?385-390)

<400>  17

Arg Gln Ile Lys Ile Trp Phe Lys Lys Gln Asn Arg Arg Met Lys Trp 
1               5                   10                  15      


Lys Lys Leu Gln Tyr Phe Ala Arg Gly Leu Leu Arg Leu Ala Leu Gln 
            20                  25                  30          


Gly Lys Thr 
        35  


