                         SEQUENCE LISTING

<110>  Ventana Medical Systems, Inc. et al.
 
<120>  G-ALPHA, INTERACTING VESICLE ASSOCIATED PROTEIN (GIV) AS A 
       PREDICTIVE MARKER IN STAGE II COLORECTAL CANCER

<130>  R69606PC

<150>  US61/940,705
<151>  2014-02-17

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  1870
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Asn Glu Ile Phe Thr Pro Leu Leu Glu Gln Phe Met Thr Ser 
1               5                   10                  15      


Pro Leu Val Thr Trp Val Lys Thr Phe Gly Pro Leu Ala Ala Gly Asn 
            20                  25                  30          


Gly Thr Asn Leu Asp Glu Tyr Val Ala Leu Val Asp Gly Val Phe Leu 
        35                  40                  45              


Asn Gln Val Met Leu Gln Ile Asn Pro Lys Leu Glu Ser Gln Arg Val 
    50                  55                  60                  


Asn Lys Lys Val Asn Asn Asp Ala Ser Leu Arg Met His Asn Leu Ser 
65                  70                  75                  80  


Ile Leu Val Arg Gln Ile Lys Phe Tyr Tyr Gln Glu Thr Leu Gln Gln 
                85                  90                  95      


Leu Ile Met Met Ser Leu Pro Asn Val Leu Ile Ile Gly Lys Asn Pro 
            100                 105                 110         


Phe Ser Glu Gln Gly Thr Glu Glu Val Lys Lys Leu Leu Leu Leu Leu 
        115                 120                 125             


Leu Gly Cys Ala Val Gln Cys Gln Lys Lys Glu Glu Phe Ile Glu Arg 
    130                 135                 140                 


Ile Gln Gly Leu Asp Phe Asp Thr Lys Ala Ala Val Ala Ala His Ile 
145                 150                 155                 160 


Gln Glu Val Thr His Asn Gln Glu Asn Val Phe Asp Leu Gln Trp Met 
                165                 170                 175     


Glu Val Thr Asp Met Ser Gln Glu Asp Ile Glu Pro Leu Leu Lys Asn 
            180                 185                 190         


Met Ala Leu His Leu Lys Arg Leu Ile Asp Glu Arg Asp Glu His Ser 
        195                 200                 205             


Glu Thr Ile Ile Glu Leu Ser Glu Glu Arg Asp Gly Leu His Phe Leu 
    210                 215                 220                 


Pro His Ala Ser Ser Ser Ala Gln Ser Pro Cys Gly Ser Pro Gly Met 
225                 230                 235                 240 


Lys Arg Thr Glu Ser Arg Gln His Leu Ser Val Glu Leu Ala Asp Ala 
                245                 250                 255     


Lys Ala Lys Ile Arg Arg Leu Arg Gln Glu Leu Glu Glu Lys Thr Glu 
            260                 265                 270         


Gln Leu Leu Asp Cys Lys Gln Glu Leu Glu Gln Met Glu Ile Glu Leu 
        275                 280                 285             


Lys Arg Leu Gln Gln Glu Asn Met Asn Leu Leu Ser Asp Ala Arg Ser 
    290                 295                 300                 


Ala Arg Met Tyr Arg Asp Glu Leu Asp Ala Leu Arg Glu Lys Ala Val 
305                 310                 315                 320 


Arg Val Asp Lys Leu Glu Ser Glu Val Ser Arg Tyr Lys Glu Arg Leu 
                325                 330                 335     


His Asp Ile Glu Phe Tyr Lys Ala Arg Val Glu Glu Leu Lys Glu Asp 
            340                 345                 350         


Asn Gln Val Leu Leu Glu Thr Lys Thr Met Leu Glu Asp Gln Leu Glu 
        355                 360                 365             


Gly Thr Arg Ala Arg Ser Asp Lys Leu His Glu Leu Glu Lys Glu Asn 
    370                 375                 380                 


Leu Gln Leu Lys Ala Lys Leu His Asp Met Glu Met Glu Arg Asp Met 
385                 390                 395                 400 


Asp Arg Lys Lys Ile Glu Glu Leu Met Glu Glu Asn Met Thr Leu Glu 
                405                 410                 415     


Met Ala Gln Lys Gln Ser Met Asp Glu Ser Leu His Leu Gly Trp Glu 
            420                 425                 430         


Leu Glu Gln Ile Ser Arg Thr Ser Glu Leu Ser Glu Ala Pro Gln Lys 
        435                 440                 445             


Ser Leu Gly His Glu Val Asn Glu Leu Thr Ser Ser Arg Leu Leu Lys 
    450                 455                 460                 


Leu Glu Met Glu Asn Gln Ser Leu Thr Lys Thr Val Glu Glu Leu Arg 
465                 470                 475                 480 


Thr Thr Val Asp Ser Val Glu Gly Asn Ala Ser Lys Ile Leu Lys Met 
                485                 490                 495     


Glu Lys Glu Asn Gln Arg Leu Ser Lys Lys Val Glu Ile Leu Glu Asn 
            500                 505                 510         


Glu Ile Val Gln Glu Lys Gln Ser Leu Gln Asn Cys Gln Asn Leu Ser 
        515                 520                 525             


Lys Asp Leu Met Lys Glu Lys Ala Gln Leu Glu Lys Thr Ile Glu Thr 
    530                 535                 540                 


Leu Arg Glu Asn Ser Glu Arg Gln Ile Lys Ile Leu Glu Gln Glu Asn 
545                 550                 555                 560 


Glu His Leu Asn Gln Thr Val Ser Ser Leu Arg Gln Arg Ser Gln Ile 
                565                 570                 575     


Ser Ala Glu Ala Arg Val Lys Asp Ile Glu Lys Glu Asn Lys Ile Leu 
            580                 585                 590         


His Glu Ser Ile Lys Glu Thr Ser Ser Lys Leu Ser Lys Ile Glu Phe 
        595                 600                 605             


Glu Lys Arg Gln Ile Lys Lys Glu Leu Glu His Tyr Lys Glu Lys Gly 
    610                 615                 620                 


Glu Arg Ala Glu Glu Leu Glu Asn Glu Leu His His Leu Glu Lys Glu 
625                 630                 635                 640 


Asn Glu Leu Leu Gln Lys Lys Ile Thr Asn Leu Lys Ile Thr Cys Glu 
                645                 650                 655     


Lys Ile Glu Ala Leu Glu Gln Glu Asn Ser Glu Leu Glu Arg Glu Asn 
            660                 665                 670         


Arg Lys Leu Lys Lys Thr Leu Asp Ser Phe Lys Asn Leu Thr Phe Gln 
        675                 680                 685             


Leu Glu Ser Leu Glu Lys Glu Asn Ser Gln Leu Asp Glu Glu Asn Leu 
    690                 695                 700                 


Glu Leu Arg Arg Asn Val Glu Ser Leu Lys Cys Ala Ser Met Lys Met 
705                 710                 715                 720 


Ala Gln Leu Gln Leu Glu Asn Lys Glu Leu Glu Ser Glu Lys Glu Gln 
                725                 730                 735     


Leu Lys Lys Gly Leu Glu Leu Leu Lys Ala Ser Phe Lys Lys Thr Glu 
            740                 745                 750         


Arg Leu Glu Val Ser Tyr Gln Gly Leu Asp Ile Glu Asn Gln Arg Leu 
        755                 760                 765             


Gln Lys Thr Leu Glu Asn Ser Asn Lys Lys Ile Gln Gln Leu Glu Ser 
    770                 775                 780                 


Glu Leu Gln Asp Leu Glu Met Glu Asn Gln Thr Leu Gln Lys Asn Leu 
785                 790                 795                 800 


Glu Glu Leu Lys Ile Ser Ser Lys Arg Leu Glu Gln Leu Glu Lys Glu 
                805                 810                 815     


Asn Lys Ser Leu Glu Gln Glu Thr Ser Gln Leu Glu Lys Asp Lys Lys 
            820                 825                 830         


Gln Leu Glu Lys Glu Asn Lys Arg Leu Arg Gln Gln Ala Glu Ile Lys 
        835                 840                 845             


Asp Thr Thr Leu Glu Glu Asn Asn Val Lys Ile Gly Asn Leu Glu Lys 
    850                 855                 860                 


Glu Asn Lys Thr Leu Ser Lys Glu Ile Gly Ile Tyr Lys Glu Ser Cys 
865                 870                 875                 880 


Val Arg Leu Lys Glu Leu Glu Lys Glu Asn Lys Glu Leu Val Lys Arg 
                885                 890                 895     


Ala Thr Ile Asp Ile Lys Thr Leu Val Thr Leu Arg Glu Asp Leu Val 
            900                 905                 910         


Ser Glu Lys Leu Lys Thr Gln Gln Met Asn Asn Asp Leu Glu Lys Leu 
        915                 920                 925             


Thr His Glu Leu Glu Lys Ile Gly Leu Asn Lys Glu Arg Leu Leu His 
    930                 935                 940                 


Asp Glu Gln Ser Thr Asp Asp Arg Tyr Lys Leu Leu Glu Ser Lys Leu 
945                 950                 955                 960 


Glu Ser Thr Leu Lys Lys Ser Leu Glu Ile Lys Glu Glu Lys Ile Ala 
                965                 970                 975     


Ala Leu Glu Ala Arg Leu Glu Glu Ser Thr Asn Tyr Asn Gln Gln Leu 
            980                 985                 990         


Arg Gln Glu Leu Lys Thr Val Lys  Lys Asn Tyr Glu Ala  Leu Lys Gln 
        995                 1000                 1005             


Arg Gln  Asp Glu Glu Arg Met  Val Gln Ser Ser Pro  Pro Ile Ser 
    1010                 1015                 1020             


Gly Glu  Asp Asn Lys Trp Glu  Arg Glu Ser Gln Glu  Thr Thr Arg 
    1025                 1030                 1035             


Glu Leu  Leu Lys Val Lys Asp  Arg Leu Ile Glu Val  Glu Arg Asn 
    1040                 1045                 1050             


Asn Ala  Thr Leu Gln Ala Glu  Lys Gln Ala Leu Lys  Thr Gln Leu 
    1055                 1060                 1065             


Lys Gln  Leu Glu Thr Gln Asn  Asn Asn Leu Gln Ala  Gln Ile Leu 
    1070                 1075                 1080             


Ala Leu  Gln Arg Gln Thr Val  Ser Leu Gln Glu Gln  Asn Thr Thr 
    1085                 1090                 1095             


Leu Gln  Thr Gln Asn Ala Lys  Leu Gln Val Glu Asn  Ser Thr Leu 
    1100                 1105                 1110             


Asn Ser  Gln Ser Thr Ser Leu  Met Asn Gln Asn Ala  Gln Leu Leu 
    1115                 1120                 1125             


Ile Gln  Gln Ser Ser Leu Glu  Asn Glu Asn Glu Ser  Val Ile Lys 
    1130                 1135                 1140             


Glu Arg  Glu Asp Leu Lys Ser  Leu Tyr Asp Ser Leu  Ile Lys Asp 
    1145                 1150                 1155             


His Glu  Lys Leu Glu Leu Leu  His Glu Arg Gln Ala  Ser Glu Tyr 
    1160                 1165                 1170             


Glu Ser  Leu Ile Ser Lys His  Gly Thr Leu Lys Ser  Ala His Lys 
    1175                 1180                 1185             


Asn Leu  Glu Val Glu His Arg  Asp Leu Glu Asp Arg  Tyr Asn Gln 
    1190                 1195                 1200             


Leu Leu  Lys Gln Lys Gly Gln  Leu Glu Asp Leu Glu  Lys Met Leu 
    1205                 1210                 1215             


Lys Val  Glu Gln Glu Lys Met  Leu Leu Glu Asn Lys  Asn His Glu 
    1220                 1225                 1230             


Thr Val  Ala Ala Glu Tyr Lys  Lys Leu Cys Gly Glu  Asn Asp Arg 
    1235                 1240                 1245             


Leu Asn  His Thr Tyr Ser Gln  Leu Leu Lys Glu Thr  Glu Val Leu 
    1250                 1255                 1260             


Gln Thr  Asp His Lys Asn Leu  Lys Ser Leu Leu Asn  Asn Ser Lys 
    1265                 1270                 1275             


Leu Glu  Gln Thr Arg Leu Glu  Ala Glu Phe Ser Lys  Leu Lys Glu 
    1280                 1285                 1290             


Gln Tyr  Gln Gln Leu Asp Ile  Thr Ser Thr Lys Leu  Asn Asn Gln 
    1295                 1300                 1305             


Cys Glu  Leu Leu Ser Gln Leu  Lys Gly Asn Leu Glu  Glu Glu Asn 
    1310                 1315                 1320             


Arg His  Leu Leu Asp Gln Ile  Gln Thr Leu Met Leu  Gln Asn Arg 
    1325                 1330                 1335             


Thr Leu  Leu Glu Gln Asn Met  Glu Ser Lys Asp Leu  Phe His Val 
    1340                 1345                 1350             


Glu Gln  Arg Gln Tyr Ile Asp  Lys Leu Asn Glu Leu  Arg Arg Gln 
    1355                 1360                 1365             


Lys Glu  Lys Leu Glu Glu Lys  Ile Met Asp Gln Tyr  Lys Phe Tyr 
    1370                 1375                 1380             


Asp Pro  Ser Pro Pro Arg Arg  Arg Gly Asn Trp Ile  Thr Leu Lys 
    1385                 1390                 1395             


Met Arg  Lys Leu Ile Lys Ser  Lys Lys Asp Ile Asn  Arg Glu Arg 
    1400                 1405                 1410             


Gln Lys  Ser Leu Thr Leu Thr  Pro Thr Arg Ser Asp  Ser Ser Glu 
    1415                 1420                 1425             


Gly Phe  Leu Gln Leu Pro His  Gln Asp Ser Gln Asp  Ser Ser Ser 
    1430                 1435                 1440             


Val Gly  Ser Asn Ser Leu Glu  Asp Gly Gln Thr Leu  Gly Thr Lys 
    1445                 1450                 1455             


Lys Ser  Ser Met Val Ala Leu  Lys Arg Leu Pro Phe  Leu Arg Asn 
    1460                 1465                 1470             


Arg Pro  Lys Asp Lys Asp Lys  Met Lys Ala Cys Tyr  Arg Arg Ser 
    1475                 1480                 1485             


Met Ser  Met Asn Asp Leu Val  Gln Ser Met Val Leu  Ala Gly Gln 
    1490                 1495                 1500             


Trp Thr  Gly Ser Thr Glu Asn  Leu Glu Val Pro Asp  Asp Ile Ser 
    1505                 1510                 1515             


Thr Gly  Lys Arg Arg Lys Glu  Leu Gly Ala Met Ala  Phe Ser Thr 
    1520                 1525                 1530             


Thr Ala  Ile Asn Phe Ser Thr  Val Asn Ser Ser Ala  Gly Phe Arg 
    1535                 1540                 1545             


Ser Lys  Gln Leu Val Asn Asn  Lys Asp Thr Thr Ser  Phe Glu Asp 
    1550                 1555                 1560             


Ile Ser  Pro Gln Gly Val Ser  Asp Asp Ser Ser Thr  Gly Ser Arg 
    1565                 1570                 1575             


Val His  Ala Ser Arg Pro Ala  Ser Leu Asp Ser Gly  Arg Thr Ser 
    1580                 1585                 1590             


Thr Ser  Asn Ser Asn Asn Asn  Ala Ser Leu His Glu  Val Lys Ala 
    1595                 1600                 1605             


Gly Ala  Val Asn Asn Gln Ser  Arg Pro Gln Ser His  Ser Ser Gly 
    1610                 1615                 1620             


Glu Phe  Ser Leu Leu His Asp  His Glu Ala Trp Ser  Ser Ser Gly 
    1625                 1630                 1635             


Ser Ser  Pro Ile Gln Tyr Leu  Lys Arg Gln Thr Arg  Ser Ser Pro 
    1640                 1645                 1650             


Val Leu  Gln His Lys Ile Ser  Glu Thr Leu Glu Ser  Arg His His 
    1655                 1660                 1665             


Lys Ile  Lys Thr Gly Ser Pro  Gly Ser Glu Val Val  Thr Leu Gln 
    1670                 1675                 1680             


Gln Phe  Leu Glu Glu Ser Asn  Lys Leu Thr Ser Val  Gln Ile Lys 
    1685                 1690                 1695             


Ser Ser  Ser Gln Glu Asn Leu  Leu Asp Glu Val Met  Lys Ser Leu 
    1700                 1705                 1710             


Ser Val  Ser Ser Asp Phe Leu  Gly Lys Asp Lys Pro  Val Ser Cys 
    1715                 1720                 1725             


Gly Leu  Ala Arg Ser Val Ser  Gly Lys Thr Pro Gly  Asp Phe Tyr 
    1730                 1735                 1740             


Asp Arg  Arg Thr Thr Lys Pro  Glu Phe Leu Arg Pro  Gly Pro Arg 
    1745                 1750                 1755             


Lys Thr  Glu Asp Thr Tyr Phe  Ile Ser Ser Ala Gly  Lys Pro Thr 
    1760                 1765                 1770             


Pro Gly  Thr Gln Gly Lys Ile  Lys Leu Val Lys Glu  Ser Ser Leu 
    1775                 1780                 1785             


Ser Arg  Gln Ser Lys Asp Ser  Asn Pro Tyr Ala Thr  Leu Pro Arg 
    1790                 1795                 1800             


Ala Ser  Ser Val Ile Ser Thr  Ala Glu Gly Thr Thr  Arg Arg Thr 
    1805                 1810                 1815             


Ser Ile  His Asp Phe Leu Thr  Lys Asp Ser Arg Leu  Pro Ile Ser 
    1820                 1825                 1830             


Val Asp  Ser Pro Pro Ala Ala  Ala Asp Ser Asn Thr  Thr Ala Ala 
    1835                 1840                 1845             


Ser Asn  Val Asp Lys Val Gln  Glu Ser Arg Asn Ser  Lys Ser Arg 
    1850                 1855                 1860             


Ser Arg  Glu Gln Gln Ser Ser  
    1865                 1870 


<210>  2
<211>  1871
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Asn Glu Ile Phe Thr Pro Leu Leu Glu Gln Phe Met Thr Ser 
1               5                   10                  15      


Pro Leu Val Thr Trp Val Lys Thr Phe Gly Pro Leu Ala Ala Gly Asn 
            20                  25                  30          


Gly Thr Asn Leu Asp Glu Tyr Val Ala Leu Val Asp Gly Val Phe Leu 
        35                  40                  45              


Asn Gln Val Met Leu Gln Ile Asn Pro Lys Leu Glu Ser Gln Arg Val 
    50                  55                  60                  


Asn Lys Lys Val Asn Asn Asp Ala Ser Leu Arg Met His Asn Leu Ser 
65                  70                  75                  80  


Ile Leu Val Arg Gln Ile Lys Phe Tyr Tyr Gln Glu Thr Leu Gln Gln 
                85                  90                  95      


Leu Ile Met Met Ser Leu Pro Asn Val Leu Ile Ile Gly Lys Asn Pro 
            100                 105                 110         


Phe Ser Glu Gln Gly Thr Glu Glu Val Lys Lys Leu Leu Leu Leu Leu 
        115                 120                 125             


Leu Gly Cys Ala Val Gln Cys Gln Lys Lys Glu Glu Phe Ile Glu Arg 
    130                 135                 140                 


Ile Gln Gly Leu Asp Phe Asp Thr Lys Ala Ala Val Ala Ala His Ile 
145                 150                 155                 160 


Gln Glu Val Thr His Asn Gln Glu Asn Val Phe Asp Leu Gln Trp Met 
                165                 170                 175     


Glu Val Thr Asp Met Ser Gln Glu Asp Ile Glu Pro Leu Leu Lys Asn 
            180                 185                 190         


Met Ala Leu His Leu Lys Arg Leu Ile Asp Glu Arg Asp Glu His Ser 
        195                 200                 205             


Glu Thr Ile Ile Glu Leu Ser Glu Glu Arg Asp Gly Leu His Phe Leu 
    210                 215                 220                 


Pro His Ala Ser Ser Ser Ala Gln Ser Pro Cys Gly Ser Pro Gly Met 
225                 230                 235                 240 


Lys Arg Thr Glu Ser Arg Gln His Leu Ser Val Glu Leu Ala Asp Ala 
                245                 250                 255     


Lys Ala Lys Ile Arg Arg Leu Arg Gln Glu Leu Glu Glu Lys Thr Glu 
            260                 265                 270         


Gln Leu Leu Asp Cys Lys Gln Glu Leu Glu Gln Met Glu Ile Glu Leu 
        275                 280                 285             


Lys Arg Leu Gln Gln Glu Asn Met Asn Leu Leu Ser Asp Ala Arg Ser 
    290                 295                 300                 


Ala Arg Met Tyr Arg Asp Glu Leu Asp Ala Leu Arg Glu Lys Ala Val 
305                 310                 315                 320 


Arg Val Asp Lys Leu Glu Ser Glu Val Ser Arg Tyr Lys Glu Arg Leu 
                325                 330                 335     


His Asp Ile Glu Phe Tyr Lys Ala Arg Val Glu Glu Leu Lys Glu Asp 
            340                 345                 350         


Asn Gln Val Leu Leu Glu Thr Lys Thr Met Leu Glu Asp Gln Leu Glu 
        355                 360                 365             


Gly Thr Arg Ala Arg Ser Asp Lys Leu His Glu Leu Glu Lys Glu Asn 
    370                 375                 380                 


Leu Gln Leu Lys Ala Lys Leu His Asp Met Glu Met Glu Arg Asp Met 
385                 390                 395                 400 


Asp Arg Lys Lys Ile Glu Glu Leu Met Glu Glu Asn Met Thr Leu Glu 
                405                 410                 415     


Met Ala Gln Lys Gln Ser Met Asp Glu Ser Leu His Leu Gly Trp Glu 
            420                 425                 430         


Leu Glu Gln Ile Ser Arg Thr Ser Glu Leu Ser Glu Ala Pro Gln Lys 
        435                 440                 445             


Ser Leu Gly His Glu Val Asn Glu Leu Thr Ser Ser Arg Leu Leu Lys 
    450                 455                 460                 


Leu Glu Met Glu Asn Gln Ser Leu Thr Lys Thr Val Glu Glu Leu Arg 
465                 470                 475                 480 


Thr Thr Val Asp Ser Val Glu Gly Asn Ala Ser Lys Ile Leu Lys Met 
                485                 490                 495     


Glu Lys Glu Asn Gln Arg Leu Ser Lys Lys Val Glu Ile Leu Glu Asn 
            500                 505                 510         


Glu Ile Val Gln Glu Lys Gln Ser Leu Gln Asn Cys Gln Asn Leu Ser 
        515                 520                 525             


Lys Asp Leu Met Lys Glu Lys Ala Gln Leu Glu Lys Thr Ile Glu Thr 
    530                 535                 540                 


Leu Arg Glu Asn Ser Glu Arg Gln Ile Lys Ile Leu Glu Gln Glu Asn 
545                 550                 555                 560 


Glu His Leu Asn Gln Thr Val Ser Ser Leu Arg Gln Arg Ser Gln Ile 
                565                 570                 575     


Ser Ala Glu Ala Arg Val Lys Asp Ile Glu Lys Glu Asn Lys Ile Leu 
            580                 585                 590         


His Glu Ser Ile Lys Glu Thr Ser Ser Lys Leu Ser Lys Ile Glu Phe 
        595                 600                 605             


Glu Lys Arg Gln Ile Lys Lys Glu Leu Glu His Tyr Lys Glu Lys Gly 
    610                 615                 620                 


Glu Arg Ala Glu Glu Leu Glu Asn Glu Leu His His Leu Glu Lys Glu 
625                 630                 635                 640 


Asn Glu Leu Leu Gln Lys Lys Ile Thr Asn Leu Lys Ile Thr Cys Glu 
                645                 650                 655     


Lys Ile Glu Ala Leu Glu Gln Glu Asn Ser Glu Leu Glu Arg Glu Asn 
            660                 665                 670         


Arg Lys Leu Lys Lys Thr Leu Asp Ser Phe Lys Asn Leu Thr Phe Gln 
        675                 680                 685             


Leu Glu Ser Leu Glu Lys Glu Asn Ser Gln Leu Asp Glu Glu Asn Leu 
    690                 695                 700                 


Glu Leu Arg Arg Asn Val Glu Ser Leu Lys Cys Ala Ser Met Lys Met 
705                 710                 715                 720 


Ala Gln Leu Gln Leu Glu Asn Lys Glu Leu Glu Ser Glu Lys Glu Gln 
                725                 730                 735     


Leu Lys Lys Gly Leu Glu Leu Leu Lys Ala Ser Phe Lys Lys Thr Glu 
            740                 745                 750         


Arg Leu Glu Val Ser Tyr Gln Gly Leu Asp Ile Glu Asn Gln Arg Leu 
        755                 760                 765             


Gln Lys Thr Leu Glu Asn Ser Asn Lys Lys Ile Gln Gln Leu Glu Ser 
    770                 775                 780                 


Glu Leu Gln Asp Leu Glu Met Glu Asn Gln Thr Leu Gln Lys Asn Leu 
785                 790                 795                 800 


Glu Glu Leu Lys Ile Ser Ser Lys Arg Leu Glu Gln Leu Glu Lys Glu 
                805                 810                 815     


Asn Lys Ser Leu Glu Gln Glu Thr Ser Gln Leu Glu Lys Asp Lys Lys 
            820                 825                 830         


Gln Leu Glu Lys Glu Asn Lys Arg Leu Arg Gln Gln Ala Glu Ile Lys 
        835                 840                 845             


Asp Thr Thr Leu Glu Glu Asn Asn Val Lys Ile Gly Asn Leu Glu Lys 
    850                 855                 860                 


Glu Asn Lys Thr Leu Ser Lys Glu Ile Gly Ile Tyr Lys Glu Ser Cys 
865                 870                 875                 880 


Val Arg Leu Lys Glu Leu Glu Lys Glu Asn Lys Glu Leu Val Lys Arg 
                885                 890                 895     


Ala Thr Ile Asp Ile Lys Thr Leu Val Thr Leu Arg Glu Asp Leu Val 
            900                 905                 910         


Ser Glu Lys Leu Lys Thr Gln Gln Met Asn Asn Asp Leu Glu Lys Leu 
        915                 920                 925             


Thr His Glu Leu Glu Lys Ile Gly Leu Asn Lys Glu Arg Leu Leu His 
    930                 935                 940                 


Asp Glu Gln Ser Thr Asp Asp Ser Arg Tyr Lys Leu Leu Glu Ser Lys 
945                 950                 955                 960 


Leu Glu Ser Thr Leu Lys Lys Ser Leu Glu Ile Lys Glu Glu Lys Ile 
                965                 970                 975     


Ala Ala Leu Glu Ala Arg Leu Glu Glu Ser Thr Asn Tyr Asn Gln Gln 
            980                 985                 990         


Leu Arg Gln Glu Leu Lys Thr Val  Lys Lys Asn Tyr Glu  Ala Leu Lys 
        995                 1000                 1005             


Gln Arg  Gln Asp Glu Glu Arg  Met Val Gln Ser Ser  Pro Pro Ile 
    1010                 1015                 1020             


Ser Gly  Glu Asp Asn Lys Trp  Glu Arg Glu Ser Gln  Glu Thr Thr 
    1025                 1030                 1035             


Arg Glu  Leu Leu Lys Val Lys  Asp Arg Leu Ile Glu  Val Glu Arg 
    1040                 1045                 1050             


Asn Asn  Ala Thr Leu Gln Ala  Glu Lys Gln Ala Leu  Lys Thr Gln 
    1055                 1060                 1065             


Leu Lys  Gln Leu Glu Thr Gln  Asn Asn Asn Leu Gln  Ala Gln Ile 
    1070                 1075                 1080             


Leu Ala  Leu Gln Arg Gln Thr  Val Ser Leu Gln Glu  Gln Asn Thr 
    1085                 1090                 1095             


Thr Leu  Gln Thr Gln Asn Ala  Lys Leu Gln Val Glu  Asn Ser Thr 
    1100                 1105                 1110             


Leu Asn  Ser Gln Ser Thr Ser  Leu Met Asn Gln Asn  Ala Gln Leu 
    1115                 1120                 1125             


Leu Ile  Gln Gln Ser Ser Leu  Glu Asn Glu Asn Glu  Ser Val Ile 
    1130                 1135                 1140             


Lys Glu  Arg Glu Asp Leu Lys  Ser Leu Tyr Asp Ser  Leu Ile Lys 
    1145                 1150                 1155             


Asp His  Glu Lys Leu Glu Leu  Leu His Glu Arg Gln  Ala Ser Glu 
    1160                 1165                 1170             


Tyr Glu  Ser Leu Ile Ser Lys  His Gly Thr Leu Lys  Ser Ala His 
    1175                 1180                 1185             


Lys Asn  Leu Glu Val Glu His  Arg Asp Leu Glu Asp  Arg Tyr Asn 
    1190                 1195                 1200             


Gln Leu  Leu Lys Gln Lys Gly  Gln Leu Glu Asp Leu  Glu Lys Met 
    1205                 1210                 1215             


Leu Lys  Val Glu Gln Glu Lys  Met Leu Leu Glu Asn  Lys Asn His 
    1220                 1225                 1230             


Glu Thr  Val Ala Ala Glu Tyr  Lys Lys Leu Cys Gly  Glu Asn Asp 
    1235                 1240                 1245             


Arg Leu  Asn His Thr Tyr Ser  Gln Leu Leu Lys Glu  Thr Glu Val 
    1250                 1255                 1260             


Leu Gln  Thr Asp His Lys Asn  Leu Lys Ser Leu Leu  Asn Asn Ser 
    1265                 1270                 1275             


Lys Leu  Glu Gln Thr Arg Leu  Glu Ala Glu Phe Ser  Lys Leu Lys 
    1280                 1285                 1290             


Glu Gln  Tyr Gln Gln Leu Asp  Ile Thr Ser Thr Lys  Leu Asn Asn 
    1295                 1300                 1305             


Gln Cys  Glu Leu Leu Ser Gln  Leu Lys Gly Asn Leu  Glu Glu Glu 
    1310                 1315                 1320             


Asn Arg  His Leu Leu Asp Gln  Ile Gln Thr Leu Met  Leu Gln Asn 
    1325                 1330                 1335             


Arg Thr  Leu Leu Glu Gln Asn  Met Glu Ser Lys Asp  Leu Phe His 
    1340                 1345                 1350             


Val Glu  Gln Arg Gln Tyr Ile  Asp Lys Leu Asn Glu  Leu Arg Arg 
    1355                 1360                 1365             


Gln Lys  Glu Lys Leu Glu Glu  Lys Ile Met Asp Gln  Tyr Lys Phe 
    1370                 1375                 1380             


Tyr Asp  Pro Ser Pro Pro Arg  Arg Arg Gly Asn Trp  Ile Thr Leu 
    1385                 1390                 1395             


Lys Met  Arg Lys Leu Ile Lys  Ser Lys Lys Asp Ile  Asn Arg Glu 
    1400                 1405                 1410             


Arg Gln  Lys Ser Leu Thr Leu  Thr Pro Thr Arg Ser  Asp Ser Ser 
    1415                 1420                 1425             


Glu Gly  Phe Leu Gln Leu Pro  His Gln Asp Ser Gln  Asp Ser Ser 
    1430                 1435                 1440             


Ser Val  Gly Ser Asn Ser Leu  Glu Asp Gly Gln Thr  Leu Gly Thr 
    1445                 1450                 1455             


Lys Lys  Ser Ser Met Val Ala  Leu Lys Arg Leu Pro  Phe Leu Arg 
    1460                 1465                 1470             


Asn Arg  Pro Lys Asp Lys Asp  Lys Met Lys Ala Cys  Tyr Arg Arg 
    1475                 1480                 1485             


Ser Met  Ser Met Asn Asp Leu  Val Gln Ser Met Val  Leu Ala Gly 
    1490                 1495                 1500             


Gln Trp  Thr Gly Ser Thr Glu  Asn Leu Glu Val Pro  Asp Asp Ile 
    1505                 1510                 1515             


Ser Thr  Gly Lys Arg Arg Lys  Glu Leu Gly Ala Met  Ala Phe Ser 
    1520                 1525                 1530             


Thr Thr  Ala Ile Asn Phe Ser  Thr Val Asn Ser Ser  Ala Gly Phe 
    1535                 1540                 1545             


Arg Ser  Lys Gln Leu Val Asn  Asn Lys Asp Thr Thr  Ser Phe Glu 
    1550                 1555                 1560             


Asp Ile  Ser Pro Gln Gly Val  Ser Asp Asp Ser Ser  Thr Gly Ser 
    1565                 1570                 1575             


Arg Val  His Ala Ser Arg Pro  Ala Ser Leu Asp Ser  Gly Arg Thr 
    1580                 1585                 1590             


Ser Thr  Ser Asn Ser Asn Asn  Asn Ala Ser Leu His  Glu Val Lys 
    1595                 1600                 1605             


Ala Gly  Ala Val Asn Asn Gln  Ser Arg Pro Gln Ser  His Ser Ser 
    1610                 1615                 1620             


Gly Glu  Phe Ser Leu Leu His  Asp His Glu Ala Trp  Ser Ser Ser 
    1625                 1630                 1635             


Gly Ser  Ser Pro Ile Gln Tyr  Leu Lys Arg Gln Thr  Arg Ser Ser 
    1640                 1645                 1650             


Pro Val  Leu Gln His Lys Ile  Ser Glu Thr Leu Glu  Ser Arg His 
    1655                 1660                 1665             


His Lys  Ile Lys Thr Gly Ser  Pro Gly Ser Glu Val  Val Thr Leu 
    1670                 1675                 1680             


Gln Gln  Phe Leu Glu Glu Ser  Asn Lys Leu Thr Ser  Val Gln Ile 
    1685                 1690                 1695             


Lys Ser  Ser Ser Gln Glu Asn  Leu Leu Asp Glu Val  Met Lys Ser 
    1700                 1705                 1710             


Leu Ser  Val Ser Ser Asp Phe  Leu Gly Lys Asp Lys  Pro Val Ser 
    1715                 1720                 1725             


Cys Gly  Leu Ala Arg Ser Val  Ser Gly Lys Thr Pro  Gly Asp Phe 
    1730                 1735                 1740             


Tyr Asp  Arg Arg Thr Thr Lys  Pro Glu Phe Leu Arg  Pro Gly Pro 
    1745                 1750                 1755             


Arg Lys  Thr Glu Asp Thr Tyr  Phe Ile Ser Ser Ala  Gly Lys Pro 
    1760                 1765                 1770             


Thr Pro  Gly Thr Gln Gly Lys  Ile Lys Leu Val Lys  Glu Ser Ser 
    1775                 1780                 1785             


Leu Ser  Arg Gln Ser Lys Asp  Ser Asn Pro Tyr Ala  Thr Leu Pro 
    1790                 1795                 1800             


Arg Ala  Ser Ser Val Ile Ser  Thr Ala Glu Gly Thr  Thr Arg Arg 
    1805                 1810                 1815             


Thr Ser  Ile His Asp Phe Leu  Thr Lys Asp Ser Arg  Leu Pro Ile 
    1820                 1825                 1830             


Ser Val  Asp Ser Pro Pro Ala  Ala Ala Asp Ser Asn  Thr Thr Ala 
    1835                 1840                 1845             


Ala Ser  Asn Val Asp Lys Val  Gln Glu Ser Arg Asn  Ser Lys Ser 
    1850                 1855                 1860             


Arg Ser  Arg Glu Gln Gln Ser  Ser 
    1865                 1870     


