               SEQUENCE LISTING

<110> WESTPHAL Sören
      FROMME, Tobias
      KLINGENSPOR, Martin

<120> Paracrine FGFs as active agents to treat diseases or disorders of energy homeostasis

<130> W2192 PCT S3

<150> EP14 15 5088.9
<151> 2014-02-13

<160> 84

<170> BiSSAP 1.3

<210> 1
<211> 615
<212> DNA
<213> Homo sapiens

<220> 
<223> human FGF8a

<400> 1
atgggcagcc cccgctccgc gctgagctgc ctgctgttgc acttgctggt cctctgcctc      60

caagcccagc atgtgaggga gcagagcctg gtgacggatc agctcagccg ccgcctcatc     120

cggacctacc aactctacag ccgcaccagc gggaagcacg tgcaggtcct ggccaacaag     180

cgcatcaacg ccatggcaga ggacggcgac cccttcgcaa agctcatcgt ggagacggac     240

acctttggaa gcagagttcg agtccgagga gccgagacgg gcctctacat ctgcatgaac     300

aagaagggga agctgatcgc caagagcaac ggcaaaggca aggactgcgt cttcacggag     360

attgtgctgg agaacaacta cacagcgctg cagaatgcca agtacgaggg ctggtacatg     420

gccttcaccc gcaagggccg gccccgcaag ggctccaaga cgcggcagca ccagcgtgag     480

gtccacttca tgaagcggct gccccggggc caccacacca ccgagcagag cctgcgcttc     540

gagttcctca actacccgcc cttcacgcgc agcctgcgcg gcagccagag gacttgggcc     600

cccgagcccc gatag                                                      615


<210> 2
<211> 648
<212> DNA
<213> Homo sapiens

<220> 
<223> human FGF8b

<400> 2
atgggcagcc cccgctccgc gctgagctgc ctgctgttgc acttgctggt cctctgcctc      60

caagcccagg taactgttca gtcctcacct aattttacac agcatgtgag ggagcagagc     120

ctggtgacgg atcagctcag ccgccgcctc atccggacct accaactcta cagccgcacc     180

agcgggaagc acgtgcaggt cctggccaac aagcgcatca acgccatggc agaggacggc     240

gaccccttcg caaagctcat cgtggagacg gacacctttg gaagcagagt tcgagtccga     300

ggagccgaga cgggcctcta catctgcatg aacaagaagg ggaagctgat cgccaagagc     360

aacggcaaag gcaaggactg cgtcttcacg gagattgtgc tggagaacaa ctacacagcg     420

ctgcagaatg ccaagtacga gggctggtac atggccttca cccgcaaggg ccggccccgc     480

aagggctcca agacgcggca gcaccagcgt gaggtccact tcatgaagcg gctgccccgg     540

ggccaccaca ccaccgagca gagcctgcgc ttcgagttcc tcaactaccc gcccttcacg     600

cgcagcctgc gcggcagcca gaggacttgg gcccccgagc cccgatag                  648


<210> 3
<211> 702
<212> DNA
<213> Homo sapiens

<220> 
<223> human FGF8e

<400> 3
atgggcagcc cccgctccgc gctgagctgc ctgctgttgc acttgctggt cctctgcctc      60

caagcccagg aaggcccggg caggggccct gcgctgggca gggagctcgc ttccctgttc     120

cgggctggcc gggagcccca gggtgtctcc caacagcatg tgagggagca gagcctggtg     180

acggatcagc tcagccgccg cctcatccgg acctaccaac tctacagccg caccagcggg     240

aagcacgtgc aggtcctggc caacaagcgc atcaacgcca tggcagagga cggcgacccc     300

ttcgcaaagc tcatcgtgga gacggacacc tttggaagca gagttcgagt ccgaggagcc     360

gagacgggcc tctacatctg catgaacaag aaggggaagc tgatcgccaa gagcaacggc     420

aaaggcaagg actgcgtctt cacggagatt gtgctggaga acaactacac agcgctgcag     480

aatgccaagt acgagggctg gtacatggcc ttcacccgca agggccggcc ccgcaagggc     540

tccaagacgc ggcagcacca gcgtgaggtc cacttcatga agcggctgcc ccggggccac     600

cacaccaccg agcagagcct gcgcttcgag ttcctcaact acccgccctt cacgcgcagc     660

ctgcgcggca gccagaggac ttgggccccc gagccccgat ag                        702


<210> 4
<211> 735
<212> DNA
<213> Homo sapiens

<220> 
<223> human FGF8f

<400> 4
atgggcagcc cccgctccgc gctgagctgc ctgctgttgc acttgctggt cctctgcctc      60

caagcccagg aaggcccggg caggggccct gcgctgggca gggagctcgc ttccctgttc     120

cgggctggcc gggagcccca gggtgtctcc caacaggtaa ctgttcagtc ctcacctaat     180

tttacacagc atgtgaggga gcagagcctg gtgacggatc agctcagccg ccgcctcatc     240

cggacctacc aactctacag ccgcaccagc gggaagcacg tgcaggtcct ggccaacaag     300

cgcatcaacg ccatggcaga ggacggcgac cccttcgcaa agctcatcgt ggagacggac     360

acctttggaa gcagagttcg agtccgagga gccgagacgg gcctctacat ctgcatgaac     420

aagaagggga agctgatcgc caagagcaac ggcaaaggca aggactgcgt cttcacggag     480

attgtgctgg agaacaacta cacagcgctg cagaatgcca agtacgaggg ctggtacatg     540

gccttcaccc gcaagggccg gccccgcaag ggctccaaga cgcggcagca ccagcgtgag     600

gtccacttca tgaagcggct gccccggggc caccacacca ccgagcagag cctgcgcttc     660

gagttcctca actacccgcc cttcacgcgc agcctgcgcg gcagccagag gacttgggcc     720

cccgagcccc gatag                                                      735


<210> 5
<211> 615
<212> DNA
<213> Mus musculus

<220> 
<223> murine FGF8a

<400> 5
atgggcagcc cccgctccgc gctgagctgc ctgctgttgc acttgctggt tctctgcctc      60

caagcccagc atgtgaggga gcagagcctg gtgacggatc agctcagccg ccgcctcatc     120

cggacctacc agctctacag ccgcaccagc gggaagcacg tgcaggtcct ggccaacaag     180

cgcatcaacg ccatggcaga agacggagac cccttcgcga agctcattgt ggagaccgat     240

acttttggaa gcagagtccg agttcgcggc gcagagacag gtctctacat ctgcatgaac     300

aagaagggga agctaattgc caagagcaac ggcaaaggca aggactgcgt attcacagag     360

atcgtgctgg agaacaacta cacggcgctg cagaacgcca agtacgaggg ctggtacatg     420

gcctttaccc gcaagggccg gccccgcaag ggctccaaga cgcgccagca tcagcgcgag     480

gtgcacttca tgaagcgcct gccgcggggc caccacacca ccgagcagag cctgcgcttc     540

gagttcctca actacccgcc cttcacgcgc agcctgcgcg gcagccagag gacttgggcc     600

ccggagcccc gatag                                                      615


<210> 6
<211> 648
<212> DNA
<213> Mus musculus

<220> 
<223> murine FGF8b

<400> 6
atgggcagcc cccgctccgc gctgagctgc ctgctgttgc acttgctggt tctctgcctc      60

caagcccagg taactgttca gtcctcacct aattttacac agcatgtgag ggagcagagc     120

ctggtgacgg atcagctcag ccgccgcctc atccggacct accagctcta cagccgcacc     180

agcgggaagc acgtgcaggt cctggccaac aagcgcatca acgccatggc agaagacgga     240

gaccccttcg cgaagctcat tgtggagacc gatacttttg gaagcagagt ccgagttcgc     300

ggcgcagaga caggtctcta catctgcatg aacaagaagg ggaagctaat tgccaagagc     360

aacggcaaag gcaaggactg cgtattcaca gagatcgtgc tggagaacaa ctacacggcg     420

ctgcagaacg ccaagtacga gggctggtac atggccttta cccgcaaggg ccggccccgc     480

aagggctcca agacgcgcca gcatcagcgc gaggtgcact tcatgaagcg cctgccgcgg     540

ggccaccaca ccaccgagca gagcctgcgc ttcgagttcc tcaactaccc gcccttcacg     600

cgcagcctgc gcggcagcca gaggacttgg gccccggagc cccgatag                  648


<210> 7
<211> 702
<212> DNA
<213> Mus musculus

<220> 
<223> murine FGF8e

<400> 7
atgggcagcc cccgctccgc gctgagctgc ctgctgttgc acttgctggt tctctgcctc      60

caagcccagg aaggcccggg cggggggcct gcgctgggca gggagcccac ttccctgctc     120

cgagctggcc gggagcccca gggtgtttcc caacagcatg tgagggagca gagcctggtg     180

acggatcagc tcagccgccg cctcatccgg acctaccagc tctacagccg caccagcggg     240

aagcacgtgc aggtcctggc caacaagcgc atcaacgcca tggcagaaga cggagacccc     300

ttcgcgaagc tcattgtgga gaccgatact tttggaagca gagtccgagt tcgcggcgca     360

gagacaggtc tctacatctg catgaacaag aaggggaagc taattgccaa gagcaacggc     420

aaaggcaagg actgcgtatt cacagagatc gtgctggaga acaactacac ggcgctgcag     480

aacgccaagt acgagggctg gtacatggcc tttacccgca agggccggcc ccgcaagggc     540

tccaagacgc gccagcatca gcgcgaggtg cacttcatga agcgcctgcc gcggggccac     600

cacaccaccg agcagagcct gcgcttcgag ttcctcaact acccgccctt cacgcgcagc     660

ctgcgcggca gccagaggac ttgggccccg gagccccgat ag                        702


<210> 8
<211> 735
<212> DNA
<213> Mus musculus

<220> 
<223> murine FGF8f

<400> 8
atgggcagcc cccgctccgc gctgagctgc ctgctgttgc acttgctggt tctctgcctc      60

caagcccagg aaggcccggg cggggggcct gcgctgggca gggagcccac ttccctgctc     120

cgagctggcc gggagcccca gggtgtttcc caacaggtaa ctgttcagtc ctcacctaat     180

tttacacagc atgtgaggga gcagagcctg gtgacggatc agctcagccg ccgcctcatc     240

cggacctacc agctctacag ccgcaccagc gggaagcacg tgcaggtcct ggccaacaag     300

cgcatcaacg ccatggcaga agacggagac cccttcgcga agctcattgt ggagaccgat     360

acttttggaa gcagagtccg agttcgcggc gcagagacag gtctctacat ctgcatgaac     420

aagaagggga agctaattgc caagagcaac ggcaaaggca aggactgcgt attcacagag     480

atcgtgctgg agaacaacta cacggcgctg cagaacgcca agtacgaggg ctggtacatg     540

gcctttaccc gcaagggccg gccccgcaag ggctccaaga cgcgccagca tcagcgcgag     600

gtgcacttca tgaagcgcct gccgcggggc caccacacca ccgagcagag cctgcgcttc     660

gagttcctca actacccgcc cttcacgcgc agcctgcgcg gcagccagag gacttgggcc     720

ccggagcccc gatag                                                      735


<210> 9
<211> 651
<212> DNA
<213> Homo sapiens

<220> 
<223> human FGF17

<400> 9
atgggagccg cccgcctgct gcccaacctc actctgtgct tacagctgct gattctctgc      60

tgtcaaactc agggggagaa tcacccgtct cctaatttta accagtacgt gagggaccag     120

ggcgccatga ccgaccagct gagcaggcgg cagatccgcg agtaccaact ctacagcagg     180

accagtggca agcacgtgca ggtcaccggg cgtcgcatct ccgccaccgc cgaggacggc     240

aacaagtttg ccaagctcat agtggagacg gacacgtttg gcagccgggt tcgcatcaaa     300

ggggctgaga gtgagaagta catctgtatg aacaagaggg gcaagctcat cgggaagccc     360

agcgggaaga gcaaagactg cgtgttcacg gagatcgtgc tggagaacaa ctatacggcc     420

ttccagaacg cccggcacga gggctggttc atggccttca cgcggcaggg gcggccccgc     480

caggcttccc gcagccgcca gaaccagcgc gaggcccact tcatcaagcg cctctaccaa     540

ggccagctgc ccttccccaa ccacgccgag aagcagaagc agttcgagtt tgtgggctcc     600

gcccccaccc gccggaccaa gcgcacacgg cggccccagc ccctcacgta g              651


<210> 10
<211> 651
<212> DNA
<213> Mus musculus

<220> 
<223> murine FGF17

<400> 10
atgggagccg cccgcctgct gcctaacctt accctgtgct tgcagctatt gattctctgc      60

tgtcaaacac agggggagaa tcacccgtct cctaatttta accagtacgt gagggaccag     120

ggcgctatga ccgaccagct gagcaggcgg caaatccgtg aataccagct ctacagccgg     180

accagtggca agcacgtgca ggtcaccgga cgtcgcatct ctgccaccgc agaggatggc     240

aacaagttcg ccaagctcat cgtggagaca gatacattcg gcagcagagt ccgcatcaag     300

ggggcagaga gcgagaagta catctgtatg aacaagaggg gcaagctgat tgggaagccg     360

agcgggaaga gcaaagactg cgtgttcacc gagatcgtac tggagaacaa ctacacggcc     420

ttccagaacg cccggcacga gggctggttc atggctttca ctcggcaggg ccggccacgc     480

caggcctccc ggagccgcca gaaccagcga gaggcccact tcatcaagcg cctctaccaa     540

ggccagctgc cttttcccaa ccacgctgaa aggcagaagc agttcgaatt tgtgggctcc     600

gcccccactc gcaggaccaa gcgcactcgg aggccccagt cccaaacgta g              651


<210> 11
<211> 651
<212> DNA
<213> Homo sapiens

<220> 
<223> human FGF19

<400> 11
atgcggagcg ggtgtgtggt ggtccacgta tggatcctgg ccggcctctg gctggccgtg      60

gccgggcgcc ccctcgcctt ctcggacgcg gggccccacg tgcactacgg ctggggcgac     120

cccatccgcc tgcggcacct gtacacctcc ggcccccacg ggctctccag ctgcttcctg     180

cgcatccgtg ccgacggcgt cgtggactgc gcgcggggcc agagcgcgca cagtttgctg     240

gagatcaagg cagtcgctct gcggaccgtg gccatcaagg gcgtgcacag cgtgcggtac     300

ctctgcatgg gcgccgacgg caagatgcag gggctgcttc agtactcgga ggaagactgt     360

gctttcgagg aggagatccg cccagatggc tacaatgtgt accgatccga gaagcaccgc     420

ctcccggtct ccctgagcag tgccaaacag cggcagctgt acaagaacag aggctttctt     480

ccactctctc atttcctgcc catgctgccc atggtcccag aggagcctga ggacctcagg     540

ggccacttgg aatctgacat gttctcttcg cccctggaga ccgacagcat ggacccattt     600

gggcttgtca ccggactgga ggccgtgagg agtcccagct ttgagaagta a              651


<210> 12
<211> 657
<212> DNA
<213> Mus musculus

<220> 
<223> murine FGF15

<400> 12
atggcgagaa agtggaacgg gcgtgcggtg gcccgagccc tggtcctggc cactctgtgg      60

ctggctgtgt ctgggcgtcc cctggctcag caatcccagt ctgtgtcaga tgaagatcca     120

ctctttctct acggctgggg caagattacc cgcctgcagt acctgtactc cgctggtccc     180

tatgtctcca actgcttcct ccgaatccgg agcgacggct ctgtggactg cgaggaggac     240

caaaacgaac gaaatttgtt ggaattccgc gcggtcgctc tgaagacgat tgccatcaag     300

gacgtcagca gcgtgcggta cctctgcatg agcgcggacg gcaagatata cgggctgatt     360

cgctactcgg aggaagactg taccttcagg gaggaaatgg actgtttagg ctacaaccag     420

tacagatcca tgaagcacca tctccatatc atcttcatcc aggccaagcc cagagaacag     480

ctccaggacc agaaaccctc aaactttatc cccgtgtttc accgctcctt ctttgaaacc     540

ggggaccagc tgaggtctaa aatgttctcc ctgcccctgg agagtgacag catggatccg     600

ttcaggatgg tggaggatgt agaccaccta gtgaagagtc ccagcttcca gaaatga        657


<210> 13
<211> 630
<212> DNA
<213> Homo sapiens

<220> 
<223> human FGF21

<400> 13
atggactcgg acgagaccgg gttcgagcac tcaggactgt gggtttctgt gctggctggt      60

cttctgctgg gagcctgcca ggcacacccc atccctgact ccagtcctct cctgcaattc     120

gggggccaag tccggcagcg gtacctctac acagatgatg cccagcagac agaagcccac     180

ctggagatca gggaggatgg gacggtgggg ggcgctgctg accagagccc cgaaagtctc     240

ctgcagctga aagccttgaa gccgggagtt attcaaatct tgggagtcaa gacatccagg     300

ttcctgtgcc agcggccaga tggggccctg tatggatcgc tccactttga ccctgaggcc     360

tgcagcttcc gggagctgct tcttgaggac ggatacaatg tttaccagtc cgaagcccac     420

ggcctcccgc tgcacctgcc agggaacaag tccccacacc gggaccctgc accccgagga     480

ccagctcgct tcctgccact accaggcctg ccccccgcac tcccggagcc acccggaatc     540

ctggcccccc agccccccga tgtgggctcc tcggaccctc tgagcatggt gggaccttcc     600

cagggccgaa gccccagcta cgcttcctga                                      630


<210> 14
<211> 633
<212> DNA
<213> Mus musculus

<220> 
<223> murine FGF21

<400> 14
atggaatgga tgagatctag agttgggacc ctgggactgt gggtccgact gctgctggct      60

gtcttcctgc tgggggtcta ccaagcatac cccatccctg actccagccc cctcctccag     120

tttgggggtc aagtccggca gaggtacctc tacacagatg acgaccaaga cactgaagcc     180

cacctggaga tcagggagga tggaacagtg gtaggcgcag cacaccgcag tccagaaagt     240

ctcctggagc tcaaagcctt gaagccaggg gtcattcaaa tcctgggtgt caaagcctct     300

aggtttcttt gccaacagcc agatggagct ctctatggat cgcctcactt tgatcctgag     360

gcctgcagct tcagagaact gctgctggag gacggttaca atgtgtacca gtctgaagcc     420

catggcctgc ccctgcgtct gcctcagaag gactccccaa accaggatgc aacatcctgg     480

ggacctgtgc gcttcctgcc catgccaggc ctgctccacg agccccaaga ccaagcagga     540

ttcctgcccc cagagccccc agatgtgggc tcctctgacc ccctgagcat ggtagagcct     600

ttacagggcc gaagccccag ctatgcgtcc tga                                  633


<210> 15
<211> 204
<212> PRT
<213> Homo sapiens

<220> 
<223> human FGF8a

<400> 15
Met Gly Ser Pro Arg Ser Ala Leu Ser Cys Leu Leu Leu His Leu Leu 
1               5                   10                  15      
Val Leu Cys Leu Gln Ala Gln His Val Arg Glu Gln Ser Leu Val Thr 
            20                  25                  30          
Asp Gln Leu Ser Arg Arg Leu Ile Arg Thr Tyr Gln Leu Tyr Ser Arg 
        35                  40                  45              
Thr Ser Gly Lys His Val Gln Val Leu Ala Asn Lys Arg Ile Asn Ala 
    50                  55                  60                  
Met Ala Glu Asp Gly Asp Pro Phe Ala Lys Leu Ile Val Glu Thr Asp 
65                  70                  75                  80  
Thr Phe Gly Ser Arg Val Arg Val Arg Gly Ala Glu Thr Gly Leu Tyr 
                85                  90                  95      
Ile Cys Met Asn Lys Lys Gly Lys Leu Ile Ala Lys Ser Asn Gly Lys 
            100                 105                 110         
Gly Lys Asp Cys Val Phe Thr Glu Ile Val Leu Glu Asn Asn Tyr Thr 
        115                 120                 125             
Ala Leu Gln Asn Ala Lys Tyr Glu Gly Trp Tyr Met Ala Phe Thr Arg 
    130                 135                 140                 
Lys Gly Arg Pro Arg Lys Gly Ser Lys Thr Arg Gln His Gln Arg Glu 
145                 150                 155                 160 
Val His Phe Met Lys Arg Leu Pro Arg Gly His His Thr Thr Glu Gln 
                165                 170                 175     
Ser Leu Arg Phe Glu Phe Leu Asn Tyr Pro Pro Phe Thr Arg Ser Leu 
            180                 185                 190         
Arg Gly Ser Gln Arg Thr Trp Ala Pro Glu Pro Arg 
        195                 200                 

<210> 16
<211> 215
<212> PRT
<213> Homo sapiens

<220> 
<223> human FGF8b

<400> 16
Met Gly Ser Pro Arg Ser Ala Leu Ser Cys Leu Leu Leu His Leu Leu 
1               5                   10                  15      
Val Leu Cys Leu Gln Ala Gln Val Thr Val Gln Ser Ser Pro Asn Phe 
            20                  25                  30          
Thr Gln His Val Arg Glu Gln Ser Leu Val Thr Asp Gln Leu Ser Arg 
        35                  40                  45              
Arg Leu Ile Arg Thr Tyr Gln Leu Tyr Ser Arg Thr Ser Gly Lys His 
    50                  55                  60                  
Val Gln Val Leu Ala Asn Lys Arg Ile Asn Ala Met Ala Glu Asp Gly 
65                  70                  75                  80  
Asp Pro Phe Ala Lys Leu Ile Val Glu Thr Asp Thr Phe Gly Ser Arg 
                85                  90                  95      
Val Arg Val Arg Gly Ala Glu Thr Gly Leu Tyr Ile Cys Met Asn Lys 
            100                 105                 110         
Lys Gly Lys Leu Ile Ala Lys Ser Asn Gly Lys Gly Lys Asp Cys Val 
        115                 120                 125             
Phe Thr Glu Ile Val Leu Glu Asn Asn Tyr Thr Ala Leu Gln Asn Ala 
    130                 135                 140                 
Lys Tyr Glu Gly Trp Tyr Met Ala Phe Thr Arg Lys Gly Arg Pro Arg 
145                 150                 155                 160 
Lys Gly Ser Lys Thr Arg Gln His Gln Arg Glu Val His Phe Met Lys 
                165                 170                 175     
Arg Leu Pro Arg Gly His His Thr Thr Glu Gln Ser Leu Arg Phe Glu 
            180                 185                 190         
Phe Leu Asn Tyr Pro Pro Phe Thr Arg Ser Leu Arg Gly Ser Gln Arg 
        195                 200                 205             
Thr Trp Ala Pro Glu Pro Arg 
    210                 215 

<210> 17
<211> 233
<212> PRT
<213> Homo sapiens

<220> 
<223> human FGF8e

<400> 17
Met Gly Ser Pro Arg Ser Ala Leu Ser Cys Leu Leu Leu His Leu Leu 
1               5                   10                  15      
Val Leu Cys Leu Gln Ala Gln Glu Gly Pro Gly Arg Gly Pro Ala Leu 
            20                  25                  30          
Gly Arg Glu Leu Ala Ser Leu Phe Arg Ala Gly Arg Glu Pro Gln Gly 
        35                  40                  45              
Val Ser Gln Gln His Val Arg Glu Gln Ser Leu Val Thr Asp Gln Leu 
    50                  55                  60                  
Ser Arg Arg Leu Ile Arg Thr Tyr Gln Leu Tyr Ser Arg Thr Ser Gly 
65                  70                  75                  80  
Lys His Val Gln Val Leu Ala Asn Lys Arg Ile Asn Ala Met Ala Glu 
                85                  90                  95      
Asp Gly Asp Pro Phe Ala Lys Leu Ile Val Glu Thr Asp Thr Phe Gly 
            100                 105                 110         
Ser Arg Val Arg Val Arg Gly Ala Glu Thr Gly Leu Tyr Ile Cys Met 
        115                 120                 125             
Asn Lys Lys Gly Lys Leu Ile Ala Lys Ser Asn Gly Lys Gly Lys Asp 
    130                 135                 140                 
Cys Val Phe Thr Glu Ile Val Leu Glu Asn Asn Tyr Thr Ala Leu Gln 
145                 150                 155                 160 
Asn Ala Lys Tyr Glu Gly Trp Tyr Met Ala Phe Thr Arg Lys Gly Arg 
                165                 170                 175     
Pro Arg Lys Gly Ser Lys Thr Arg Gln His Gln Arg Glu Val His Phe 
            180                 185                 190         
Met Lys Arg Leu Pro Arg Gly His His Thr Thr Glu Gln Ser Leu Arg 
        195                 200                 205             
Phe Glu Phe Leu Asn Tyr Pro Pro Phe Thr Arg Ser Leu Arg Gly Ser 
    210                 215                 220                 
Gln Arg Thr Trp Ala Pro Glu Pro Arg 
225                 230             

<210> 18
<211> 244
<212> PRT
<213> Homo sapiens

<220> 
<223> human FGF8f

<400> 18
Met Gly Ser Pro Arg Ser Ala Leu Ser Cys Leu Leu Leu His Leu Leu 
1               5                   10                  15      
Val Leu Cys Leu Gln Ala Gln Glu Gly Pro Gly Arg Gly Pro Ala Leu 
            20                  25                  30          
Gly Arg Glu Leu Ala Ser Leu Phe Arg Ala Gly Arg Glu Pro Gln Gly 
        35                  40                  45              
Val Ser Gln Gln Val Thr Val Gln Ser Ser Pro Asn Phe Thr Gln His 
    50                  55                  60                  
Val Arg Glu Gln Ser Leu Val Thr Asp Gln Leu Ser Arg Arg Leu Ile 
65                  70                  75                  80  
Arg Thr Tyr Gln Leu Tyr Ser Arg Thr Ser Gly Lys His Val Gln Val 
                85                  90                  95      
Leu Ala Asn Lys Arg Ile Asn Ala Met Ala Glu Asp Gly Asp Pro Phe 
            100                 105                 110         
Ala Lys Leu Ile Val Glu Thr Asp Thr Phe Gly Ser Arg Val Arg Val 
        115                 120                 125             
Arg Gly Ala Glu Thr Gly Leu Tyr Ile Cys Met Asn Lys Lys Gly Lys 
    130                 135                 140                 
Leu Ile Ala Lys Ser Asn Gly Lys Gly Lys Asp Cys Val Phe Thr Glu 
145                 150                 155                 160 
Ile Val Leu Glu Asn Asn Tyr Thr Ala Leu Gln Asn Ala Lys Tyr Glu 
                165                 170                 175     
Gly Trp Tyr Met Ala Phe Thr Arg Lys Gly Arg Pro Arg Lys Gly Ser 
            180                 185                 190         
Lys Thr Arg Gln His Gln Arg Glu Val His Phe Met Lys Arg Leu Pro 
        195                 200                 205             
Arg Gly His His Thr Thr Glu Gln Ser Leu Arg Phe Glu Phe Leu Asn 
    210                 215                 220                 
Tyr Pro Pro Phe Thr Arg Ser Leu Arg Gly Ser Gln Arg Thr Trp Ala 
225                 230                 235                 240 
Pro Glu Pro Arg 
                

<210> 19
<211> 204
<212> PRT
<213> Mus musculus

<220> 
<223> murine FGF8a

<400> 19
Met Gly Ser Pro Arg Ser Ala Leu Ser Cys Leu Leu Leu His Leu Leu 
1               5                   10                  15      
Val Leu Cys Leu Gln Ala Gln His Val Arg Glu Gln Ser Leu Val Thr 
            20                  25                  30          
Asp Gln Leu Ser Arg Arg Leu Ile Arg Thr Tyr Gln Leu Tyr Ser Arg 
        35                  40                  45              
Thr Ser Gly Lys His Val Gln Val Leu Ala Asn Lys Arg Ile Asn Ala 
    50                  55                  60                  
Met Ala Glu Asp Gly Asp Pro Phe Ala Lys Leu Ile Val Glu Thr Asp 
65                  70                  75                  80  
Thr Phe Gly Ser Arg Val Arg Val Arg Gly Ala Glu Thr Gly Leu Tyr 
                85                  90                  95      
Ile Cys Met Asn Lys Lys Gly Lys Leu Ile Ala Lys Ser Asn Gly Lys 
            100                 105                 110         
Gly Lys Asp Cys Val Phe Thr Glu Ile Val Leu Glu Asn Asn Tyr Thr 
        115                 120                 125             
Ala Leu Gln Asn Ala Lys Tyr Glu Gly Trp Tyr Met Ala Phe Thr Arg 
    130                 135                 140                 
Lys Gly Arg Pro Arg Lys Gly Ser Lys Thr Arg Gln His Gln Arg Glu 
145                 150                 155                 160 
Val His Phe Met Lys Arg Leu Pro Arg Gly His His Thr Thr Glu Gln 
                165                 170                 175     
Ser Leu Arg Phe Glu Phe Leu Asn Tyr Pro Pro Phe Thr Arg Ser Leu 
            180                 185                 190         
Arg Gly Ser Gln Arg Thr Trp Ala Pro Glu Pro Arg 
        195                 200                 

<210> 20
<211> 215
<212> PRT
<213> Mus musculus

<220> 
<223> murine FGF8b

<400> 20
Met Gly Ser Pro Arg Ser Ala Leu Ser Cys Leu Leu Leu His Leu Leu 
1               5                   10                  15      
Val Leu Cys Leu Gln Ala Gln Val Thr Val Gln Ser Ser Pro Asn Phe 
            20                  25                  30          
Thr Gln His Val Arg Glu Gln Ser Leu Val Thr Asp Gln Leu Ser Arg 
        35                  40                  45              
Arg Leu Ile Arg Thr Tyr Gln Leu Tyr Ser Arg Thr Ser Gly Lys His 
    50                  55                  60                  
Val Gln Val Leu Ala Asn Lys Arg Ile Asn Ala Met Ala Glu Asp Gly 
65                  70                  75                  80  
Asp Pro Phe Ala Lys Leu Ile Val Glu Thr Asp Thr Phe Gly Ser Arg 
                85                  90                  95      
Val Arg Val Arg Gly Ala Glu Thr Gly Leu Tyr Ile Cys Met Asn Lys 
            100                 105                 110         
Lys Gly Lys Leu Ile Ala Lys Ser Asn Gly Lys Gly Lys Asp Cys Val 
        115                 120                 125             
Phe Thr Glu Ile Val Leu Glu Asn Asn Tyr Thr Ala Leu Gln Asn Ala 
    130                 135                 140                 
Lys Tyr Glu Gly Trp Tyr Met Ala Phe Thr Arg Lys Gly Arg Pro Arg 
145                 150                 155                 160 
Lys Gly Ser Lys Thr Arg Gln His Gln Arg Glu Val His Phe Met Lys 
                165                 170                 175     
Arg Leu Pro Arg Gly His His Thr Thr Glu Gln Ser Leu Arg Phe Glu 
            180                 185                 190         
Phe Leu Asn Tyr Pro Pro Phe Thr Arg Ser Leu Arg Gly Ser Gln Arg 
        195                 200                 205             
Thr Trp Ala Pro Glu Pro Arg 
    210                 215 

<210> 21
<211> 233
<212> PRT
<213> Mus musculus

<220> 
<223> murine FGF8e

<400> 21
Met Gly Ser Pro Arg Ser Ala Leu Ser Cys Leu Leu Leu His Leu Leu 
1               5                   10                  15      
Val Leu Cys Leu Gln Ala Gln Glu Gly Pro Gly Gly Gly Pro Ala Leu 
            20                  25                  30          
Gly Arg Glu Pro Thr Ser Leu Leu Arg Ala Gly Arg Glu Pro Gln Gly 
        35                  40                  45              
Val Ser Gln Gln His Val Arg Glu Gln Ser Leu Val Thr Asp Gln Leu 
    50                  55                  60                  
Ser Arg Arg Leu Ile Arg Thr Tyr Gln Leu Tyr Ser Arg Thr Ser Gly 
65                  70                  75                  80  
Lys His Val Gln Val Leu Ala Asn Lys Arg Ile Asn Ala Met Ala Glu 
                85                  90                  95      
Asp Gly Asp Pro Phe Ala Lys Leu Ile Val Glu Thr Asp Thr Phe Gly 
            100                 105                 110         
Ser Arg Val Arg Val Arg Gly Ala Glu Thr Gly Leu Tyr Ile Cys Met 
        115                 120                 125             
Asn Lys Lys Gly Lys Leu Ile Ala Lys Ser Asn Gly Lys Gly Lys Asp 
    130                 135                 140                 
Cys Val Phe Thr Glu Ile Val Leu Glu Asn Asn Tyr Thr Ala Leu Gln 
145                 150                 155                 160 
Asn Ala Lys Tyr Glu Gly Trp Tyr Met Ala Phe Thr Arg Lys Gly Arg 
                165                 170                 175     
Pro Arg Lys Gly Ser Lys Thr Arg Gln His Gln Arg Glu Val His Phe 
            180                 185                 190         
Met Lys Arg Leu Pro Arg Gly His His Thr Thr Glu Gln Ser Leu Arg 
        195                 200                 205             
Phe Glu Phe Leu Asn Tyr Pro Pro Phe Thr Arg Ser Leu Arg Gly Ser 
    210                 215                 220                 
Gln Arg Thr Trp Ala Pro Glu Pro Arg 
225                 230             

<210> 22
<211> 244
<212> PRT
<213> Mus musculus

<220> 
<223> murine FGF8f

<400> 22
Met Gly Ser Pro Arg Ser Ala Leu Ser Cys Leu Leu Leu His Leu Leu 
1               5                   10                  15      
Val Leu Cys Leu Gln Ala Gln Glu Gly Pro Gly Gly Gly Pro Ala Leu 
            20                  25                  30          
Gly Arg Glu Pro Thr Ser Leu Leu Arg Ala Gly Arg Glu Pro Gln Gly 
        35                  40                  45              
Val Ser Gln Gln Val Thr Val Gln Ser Ser Pro Asn Phe Thr Gln His 
    50                  55                  60                  
Val Arg Glu Gln Ser Leu Val Thr Asp Gln Leu Ser Arg Arg Leu Ile 
65                  70                  75                  80  
Arg Thr Tyr Gln Leu Tyr Ser Arg Thr Ser Gly Lys His Val Gln Val 
                85                  90                  95      
Leu Ala Asn Lys Arg Ile Asn Ala Met Ala Glu Asp Gly Asp Pro Phe 
            100                 105                 110         
Ala Lys Leu Ile Val Glu Thr Asp Thr Phe Gly Ser Arg Val Arg Val 
        115                 120                 125             
Arg Gly Ala Glu Thr Gly Leu Tyr Ile Cys Met Asn Lys Lys Gly Lys 
    130                 135                 140                 
Leu Ile Ala Lys Ser Asn Gly Lys Gly Lys Asp Cys Val Phe Thr Glu 
145                 150                 155                 160 
Ile Val Leu Glu Asn Asn Tyr Thr Ala Leu Gln Asn Ala Lys Tyr Glu 
                165                 170                 175     
Gly Trp Tyr Met Ala Phe Thr Arg Lys Gly Arg Pro Arg Lys Gly Ser 
            180                 185                 190         
Lys Thr Arg Gln His Gln Arg Glu Val His Phe Met Lys Arg Leu Pro 
        195                 200                 205             
Arg Gly His His Thr Thr Glu Gln Ser Leu Arg Phe Glu Phe Leu Asn 
    210                 215                 220                 
Tyr Pro Pro Phe Thr Arg Ser Leu Arg Gly Ser Gln Arg Thr Trp Ala 
225                 230                 235                 240 
Pro Glu Pro Arg 
                

<210> 23
<211> 216
<212> PRT
<213> Homo sapiens

<220> 
<223> human FGF17

<400> 23
Met Gly Ala Ala Arg Leu Leu Pro Asn Leu Thr Leu Cys Leu Gln Leu 
1               5                   10                  15      
Leu Ile Leu Cys Cys Gln Thr Gln Gly Glu Asn His Pro Ser Pro Asn 
            20                  25                  30          
Phe Asn Gln Tyr Val Arg Asp Gln Gly Ala Met Thr Asp Gln Leu Ser 
        35                  40                  45              
Arg Arg Gln Ile Arg Glu Tyr Gln Leu Tyr Ser Arg Thr Ser Gly Lys 
    50                  55                  60                  
His Val Gln Val Thr Gly Arg Arg Ile Ser Ala Thr Ala Glu Asp Gly 
65                  70                  75                  80  
Asn Lys Phe Ala Lys Leu Ile Val Glu Thr Asp Thr Phe Gly Ser Arg 
                85                  90                  95      
Val Arg Ile Lys Gly Ala Glu Ser Glu Lys Tyr Ile Cys Met Asn Lys 
            100                 105                 110         
Arg Gly Lys Leu Ile Gly Lys Pro Ser Gly Lys Ser Lys Asp Cys Val 
        115                 120                 125             
Phe Thr Glu Ile Val Leu Glu Asn Asn Tyr Thr Ala Phe Gln Asn Ala 
    130                 135                 140                 
Arg His Glu Gly Trp Phe Met Ala Phe Thr Arg Gln Gly Arg Pro Arg 
145                 150                 155                 160 
Gln Ala Ser Arg Ser Arg Gln Asn Gln Arg Glu Ala His Phe Ile Lys 
                165                 170                 175     
Arg Leu Tyr Gln Gly Gln Leu Pro Phe Pro Asn His Ala Glu Lys Gln 
            180                 185                 190         
Lys Gln Phe Glu Phe Val Gly Ser Ala Pro Thr Arg Arg Thr Lys Arg 
        195                 200                 205             
Thr Arg Arg Pro Gln Pro Leu Thr 
    210                 215     

<210> 24
<211> 216
<212> PRT
<213> Mus musculus

<220> 
<223> murine FGF17

<400> 24
Met Gly Ala Ala Arg Leu Leu Pro Asn Leu Thr Leu Cys Leu Gln Leu 
1               5                   10                  15      
Leu Ile Leu Cys Cys Gln Thr Gln Gly Glu Asn His Pro Ser Pro Asn 
            20                  25                  30          
Phe Asn Gln Tyr Val Arg Asp Gln Gly Ala Met Thr Asp Gln Leu Ser 
        35                  40                  45              
Arg Arg Gln Ile Arg Glu Tyr Gln Leu Tyr Ser Arg Thr Ser Gly Lys 
    50                  55                  60                  
His Val Gln Val Thr Gly Arg Arg Ile Ser Ala Thr Ala Glu Asp Gly 
65                  70                  75                  80  
Asn Lys Phe Ala Lys Leu Ile Val Glu Thr Asp Thr Phe Gly Ser Arg 
                85                  90                  95      
Val Arg Ile Lys Gly Ala Glu Ser Glu Lys Tyr Ile Cys Met Asn Lys 
            100                 105                 110         
Arg Gly Lys Leu Ile Gly Lys Pro Ser Gly Lys Ser Lys Asp Cys Val 
        115                 120                 125             
Phe Thr Glu Ile Val Leu Glu Asn Asn Tyr Thr Ala Phe Gln Asn Ala 
    130                 135                 140                 
Arg His Glu Gly Trp Phe Met Ala Phe Thr Arg Gln Gly Arg Pro Arg 
145                 150                 155                 160 
Gln Ala Ser Arg Ser Arg Gln Asn Gln Arg Glu Ala His Phe Ile Lys 
                165                 170                 175     
Arg Leu Tyr Gln Gly Gln Leu Pro Phe Pro Asn His Ala Glu Arg Gln 
            180                 185                 190         
Lys Gln Phe Glu Phe Val Gly Ser Ala Pro Thr Arg Arg Thr Lys Arg 
        195                 200                 205             
Thr Arg Arg Pro Gln Ser Gln Thr 
    210                 215     

<210> 25
<211> 216
<212> PRT
<213> Homo sapiens

<220> 
<223> human FGF19

<400> 25
Met Arg Ser Gly Cys Val Val Val His Val Trp Ile Leu Ala Gly Leu 
1               5                   10                  15      
Trp Leu Ala Val Ala Gly Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro 
            20                  25                  30          
His Val His Tyr Gly Trp Gly Asp Pro Ile Arg Leu Arg His Leu Tyr 
        35                  40                  45              
Thr Ser Gly Pro His Gly Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala 
    50                  55                  60                  
Asp Gly Val Val Asp Cys Ala Arg Gly Gln Ser Ala His Ser Leu Leu 
65                  70                  75                  80  
Glu Ile Lys Ala Val Ala Leu Arg Thr Val Ala Ile Lys Gly Val His 
                85                  90                  95      
Ser Val Arg Tyr Leu Cys Met Gly Ala Asp Gly Lys Met Gln Gly Leu 
            100                 105                 110         
Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro 
        115                 120                 125             
Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys His Arg Leu Pro Val Ser 
    130                 135                 140                 
Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu 
145                 150                 155                 160 
Pro Leu Ser His Phe Leu Pro Met Leu Pro Met Val Pro Glu Glu Pro 
                165                 170                 175     
Glu Asp Leu Arg Gly His Leu Glu Ser Asp Met Phe Ser Ser Pro Leu 
            180                 185                 190         
Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val Thr Gly Leu Glu Ala 
        195                 200                 205             
Val Arg Ser Pro Ser Phe Glu Lys 
    210                 215     

<210> 26
<211> 218
<212> PRT
<213> Mus musculus

<220> 
<223> murine FGF15

<400> 26
Met Ala Arg Lys Trp Asn Gly Arg Ala Val Ala Arg Ala Leu Val Leu 
1               5                   10                  15      
Ala Thr Leu Trp Leu Ala Val Ser Gly Arg Pro Leu Ala Gln Gln Ser 
            20                  25                  30          
Gln Ser Val Ser Asp Glu Asp Pro Leu Phe Leu Tyr Gly Trp Gly Lys 
        35                  40                  45              
Ile Thr Arg Leu Gln Tyr Leu Tyr Ser Ala Gly Pro Tyr Val Ser Asn 
    50                  55                  60                  
Cys Phe Leu Arg Ile Arg Ser Asp Gly Ser Val Asp Cys Glu Glu Asp 
65                  70                  75                  80  
Gln Asn Glu Arg Asn Leu Leu Glu Phe Arg Ala Val Ala Leu Lys Thr 
                85                  90                  95      
Ile Ala Ile Lys Asp Val Ser Ser Val Arg Tyr Leu Cys Met Ser Ala 
            100                 105                 110         
Asp Gly Lys Ile Tyr Gly Leu Ile Arg Tyr Ser Glu Glu Asp Cys Thr 
        115                 120                 125             
Phe Arg Glu Glu Met Asp Cys Leu Gly Tyr Asn Gln Tyr Arg Ser Met 
    130                 135                 140                 
Lys His His Leu His Ile Ile Phe Ile Gln Ala Lys Pro Arg Glu Gln 
145                 150                 155                 160 
Leu Gln Asp Gln Lys Pro Ser Asn Phe Ile Pro Val Phe His Arg Ser 
                165                 170                 175     
Phe Phe Glu Thr Gly Asp Gln Leu Arg Ser Lys Met Phe Ser Leu Pro 
            180                 185                 190         
Leu Glu Ser Asp Ser Met Asp Pro Phe Arg Met Val Glu Asp Val Asp 
        195                 200                 205             
His Leu Val Lys Ser Pro Ser Phe Gln Lys 
    210                 215             

<210> 27
<211> 209
<212> PRT
<213> Homo sapiens

<220> 
<223> human FGF21

<400> 27
Met Asp Ser Asp Glu Thr Gly Phe Glu His Ser Gly Leu Trp Val Ser 
1               5                   10                  15      
Val Leu Ala Gly Leu Leu Leu Gly Ala Cys Gln Ala His Pro Ile Pro 
            20                  25                  30          
Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr 
        35                  40                  45              
Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg 
    50                  55                  60                  
Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu 
65                  70                  75                  80  
Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val 
                85                  90                  95      
Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly 
            100                 105                 110         
Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu 
        115                 120                 125             
Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu 
    130                 135                 140                 
His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro Ala Pro Arg Gly 
145                 150                 155                 160 
Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Leu Pro Glu 
                165                 170                 175     
Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp 
            180                 185                 190         
Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala 
        195                 200                 205             
Ser 
    

<210> 28
<211> 210
<212> PRT
<213> Mus musculus

<220> 
<223> murine FGF21

<400> 28
Met Glu Trp Met Arg Ser Arg Val Gly Thr Leu Gly Leu Trp Val Arg 
1               5                   10                  15      
Leu Leu Leu Ala Val Phe Leu Leu Gly Val Tyr Gln Ala Tyr Pro Ile 
            20                  25                  30          
Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg 
        35                  40                  45              
Tyr Leu Tyr Thr Asp Asp Asp Gln Asp Thr Glu Ala His Leu Glu Ile 
    50                  55                  60                  
Arg Glu Asp Gly Thr Val Val Gly Ala Ala His Arg Ser Pro Glu Ser 
65                  70                  75                  80  
Leu Leu Glu Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly 
                85                  90                  95      
Val Lys Ala Ser Arg Phe Leu Cys Gln Gln Pro Asp Gly Ala Leu Tyr 
            100                 105                 110         
Gly Ser Pro His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu 
        115                 120                 125             
Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro 
    130                 135                 140                 
Leu Arg Leu Pro Gln Lys Asp Ser Pro Asn Gln Asp Ala Thr Ser Trp 
145                 150                 155                 160 
Gly Pro Val Arg Phe Leu Pro Met Pro Gly Leu Leu His Glu Pro Gln 
                165                 170                 175     
Asp Gln Ala Gly Phe Leu Pro Pro Glu Pro Pro Asp Val Gly Ser Ser 
            180                 185                 190         
Asp Pro Leu Ser Met Val Glu Pro Leu Gln Gly Arg Ser Pro Ser Tyr 
        195                 200                 205             
Ala Ser 
    210 

<210> 29
<211> 2463
<212> DNA
<213> Homo sapiens

<220> 
<223> human FGFR1

<400> 29
atgtggagct ggaagtgcct cctcttctgg gctgtgctgg tcacagccac actctgcacc      60

gctaggccgt ccccgacctt gcctgaacaa gcccagccct ggggagcccc tgtggaagtg     120

gagtccttcc tggtccaccc cggtgacctg ctgcagcttc gctgtcggct gcgggacgat     180

gtgcagagca tcaactggct gcgggacggg gtgcagctgg cggaaagcaa ccgcacccgc     240

atcacagggg aggaggtgga ggtgcaggac tccgtgcccg cagactccgg cctctatgct     300

tgcgtaacca gcagcccctc gggcagtgac accacctact tctccgtcaa tgtttcagat     360

gctctcccct cctcggagga tgatgatgat gatgatgact cctcttcaga ggagaaagaa     420

acagataaca ccaaaccaaa ccccgtagct ccatattgga catccccaga aaagatggaa     480

aagaaattgc atgcagtgcc ggctgccaag acagtgaagt tcaaatgccc ttccagtggg     540

accccaaacc ccacactgcg ctggttgaaa aatggcaaag aattcaaacc tgaccacaga     600

attggaggct acaaggtccg ttatgccacc tggagcatca taatggactc tgtggtgccc     660

tctgacaagg gcaactacac ctgcattgtg gagaatgagt acggcagcat caaccacaca     720

taccagctgg atgtcgtgga gcggtcccct caccggccca tcctgcaagc agggttgccc     780

gccaacaaaa cagtggccct gggtagcaac gtggagttca tgtgtaaggt gtacagtgac     840

ccgcagccgc acatccagtg gctaaagcac atcgaggtga atgggagcaa gattggccca     900

gacaacctgc cttatgtcca gatcttgaag actgctggag ttaataccac cgacaaagag     960

atggaggtgc ttcacttaag aaatgtctcc tttgaggacg caggggagta tacgtgcttg    1020

gcgggtaact ctatcggact ctcccatcac tctgcatggt tgaccgttct ggaagccctg    1080

gaagagaggc cggcagtgat gacctcgccc ctgtacctgg agatcatcat ctattgcaca    1140

ggggccttcc tcatctcctg catggtgggg tcggtcatcg tctacaagat gaagagtggt    1200

accaagaaga gtgacttcca cagccagatg gctgtgcaca agctggccaa gagcatccct    1260

ctgcgcagac aggtaacagt gtctgctgac tccagtgcat ccatgaactc tggggttctt    1320

ctggttcggc catcacggct ctcctccagt gggactccca tgctagcagg ggtctctgag    1380

tatgagcttc ccgaagaccc tcgctgggag ctgcctcggg acagactggt cttaggcaaa    1440

cccctgggag agggctgctt tgggcaggtg gtgttggcag aggctatcgg gctggacaag    1500

gacaaaccca accgtgtgac caaagtggct gtgaagatgt tgaagtcgga cgcaacagag    1560

aaagacttgt cagacctgat ctcagaaatg gagatgatga agatgatcgg gaagcataag    1620

aatatcatca acctgctggg ggcctgcacg caggatggtc ccttgtatgt catcgtggag    1680

tatgcctcca agggcaacct gcgggagtac ctgcaggccc ggaggccccc agggctggaa    1740

tactgctaca accccagcca caacccagag gagcagctct cctccaagga cctggtgtcc    1800

tgcgcctacc aggtggcccg aggcatggag tatctggcct ccaagaagtg catacaccga    1860

gacctggcag ccaggaatgt cctggtgaca gaggacaatg tgatgaagat agcagacttt    1920

ggcctcgcac gggacattca ccacatcgac tactataaaa agacaaccaa cggccgactg    1980

cctgtgaagt ggatggcacc cgaggcatta tttgaccgga tctacaccca ccagagtgat    2040

gtgtggtctt tcggggtgct cctgtgggag atcttcactc tgggcggctc cccatacccc    2100

ggtgtgcctg tggaggaact tttcaagctg ctgaaggagg gtcaccgcat ggacaagccc    2160

agtaactgca ccaacgagct gtacatgatg atgcgggact gctggcatgc agtgccctca    2220

cagagaccca ccttcaagca gctggtggaa gacctggacc gcatcgtggc cttgacctcc    2280

aaccaggagt acctggacct gtccatgccc ctggaccagt actcccccag ctttcccgac    2340

acccggagct ctacgtgctc ctcaggggag gattccgtct tctctcatga gccgctgccc    2400

gaggagccct gcctgccccg acacccagcc cagcttgcca atggcggact caaacgccgc    2460

tga                                                                  2463


<210> 30
<211> 2469
<212> DNA
<213> Mus musculus

<220> 
<223> murine FGFR1

<400> 30
atgtggggct ggaagtgcct cctcttctgg gctgtgctgg tcacagccac tctctgcact      60

gccaggccag ccccaacctt gcctgaacaa gctcagccct ggggagtccc tgtggaagtg     120

gagtctctcc tggtccaccc tggcgacctg ctacagcttc gctgtcggct tcgcgatgat     180

gtgcagagca tcaactggct gcgggatggg gtgcagctgg tggagagcaa ccgtacccgc     240

atcacagggg aggaggtgga ggtgcgggac tccatccccg ctgactctgg cctctacgct     300

tgcgtgacca gcagcccctc tggcagcgat accacctact tctccgtcaa tgtctcagat     360

gcactcccat cctcggaaga tgatgacgac gacgatgact cctcctcgga ggagaaagag     420

acggacaaca ccaaaccaaa ccgtaggcct gtagctccct actggacatc cccagagaaa     480

atggagaaga aactgcatgc ggtgcccgct gccaagacgg tgaagttcaa gtgcccgtcg     540

agtgggacac ccaaccccac tctgcgctgg ttgaaaaatg gcaaagagtt taagcctgac     600

caccgaattg gaggctacaa ggttcgctat gccacctgga gcatcataat ggattctgtg     660

gtgccttctg acaagggcaa ctacacctgc atcgtggaga atgagtatgg gagcatcaac     720

cacacctacc agcttgacgt cgtggaacga tctccgcacc gacccatcct tcaggcaggg     780

ctgcctgcca acaagacagt ggccctgggc agcaatgtgg agttcatgtg taaggtgtac     840

agcgatccgc agcctcacat tcagtggctg aagcacatcg aggtgaacgg gagtaagatc     900

gggccagaca acttgccgta tgtccagatc ctgaagactg ctggagttaa taccaccgac     960

aaggaaatgg aggtgcttca tctacggaat gtctcctttg aggatgcggg ggagtatacg    1020

tgcttggcgg gtaactctat cggactctcc catcactctg catggttgac cgttctggaa    1080

gccctggaag agagaccagc tgtgatgacc tcaccgctct acctggagat cattatctac    1140

tgcaccgggg ccttcctgat ctcctgcatg ttgggctctg tcatcatcta taagatgaag    1200

agcggcacca agaagagcga cttccatagc cagatggctg tgcacaagct ggccaagagc    1260

atccctctgc gcagacaggt aacagtgtca gctgactcca gtgcatccat gaactctggg    1320

gttctcctgg ttcggccctc acggctctcc tccagcggga cccccatgct ggctggagtc    1380

tccgaatatg agctccctga ggatccccgc tgggagctgc cacgagacag actggtctta    1440

ggcaaaccac ttggcgaggg ctgcttcggg caggtggtgt tggctgaggc catcgggctg    1500

gataaggaca aacccaaccg tgtgaccaaa gtggccgtga agatgttgaa gtccgacgca    1560

acggagaagg acctgtcgga tctgatctcg gagatggaga tgatgaaaat gattgggaag    1620

cacaagaata tcatcaacct tctgggagcg tgcacacagg atggtcctct ttatgtcatt    1680

gtggagtacg cctccaaagg caatctccgg gagtatctac aggcccggag gcctcctggg    1740

ctggagtact gctataaccc cagccacaac cccgaggaac agctgtcttc caaagatctg    1800

gtatcctgtg cctatcaggt ggctcggggc atggagtatc ttgcctctaa gaagtgtata    1860

caccgagacc tggctgctag gaacgtcctg gtgaccgagg ataacgtaat gaagatcgca    1920

gactttggct tagctcgaga cattcatcat atcgactact acaagaaaac caccaacggc    1980

cggctgcctg tgaagtggat ggcccctgag gcgttgtttg accggatcta cacacaccag    2040

agcgatgtgt ggtcttttgg agtgctcttg tgggagatct tcactctggg tggctcccca    2100

taccccggtg tgcctgtgga ggaacttttc aagctgctga aggagggtca tcgaatggac    2160

aagcccagta actgtaccaa tgagctgtac atgatgatgc gggactgctg gcatgcagtg    2220

ccctctcaga gacctacgtt caagcagttg gtggaagacc tggaccgcat tgtggccttg    2280

acctccaacc aggagtatct ggacctgtcc ataccgctgg accagtactc acccagcttt    2340

cccgacacac ggagctccac ctgctcctca ggggaggact ctgtcttctc tcatgagccg    2400

ttacctgagg agccctgtct gcctcgacac cccacccagc ttgccaacag tggactcaaa    2460

cggcgctga                                                            2469


<210> 31
<211> 2466
<212> DNA
<213> Homo sapiens

<220> 
<223> human FGFR2

<400> 31
atggtcagct ggggtcgttt catctgcctg gtcgtggtca ccatggcaac cttgtccctg      60

gcccggccct ccttcagttt agttgaggat accacattag agccagaaga gccaccaacc     120

aaataccaaa tctctcaacc agaagtgtac gtggctgcgc caggggagtc gctagaggtg     180

cgctgcctgt tgaaagatgc cgccgtgatc agttggacta aggatggggt gcacttgggg     240

cccaacaata ggacagtgct tattggggag tacttgcaga taaagggcgc cacgcctaga     300

gactccggcc tctatgcttg tactgccagt aggactgtag acagtgaaac ttggtacttc     360

atggtgaatg tcacagatgc catctcatcc ggagatgatg aggatgacac cgatggtgcg     420

gaagattttg tcagtgagaa cagtaacaac aagagagcac catactggac caacacagaa     480

aagatggaaa agcggctcca tgctgtgcct gcggccaaca ctgtcaagtt tcgctgccca     540

gccgggggga acccaatgcc aaccatgcgg tggctgaaaa acgggaagga gtttaagcag     600

gagcatcgca ttggaggcta caaggtacga aaccagcact ggagcctcat tatggaaagt     660

gtggtcccat ctgacaaggg aaattatacc tgtgtagtgg agaatgaata cgggtccatc     720

aatcacacgt accacctgga tgttgtggag cgatcgcctc accggcccat cctccaagcc     780

ggactgccgg caaatgcctc cacagtggtc ggaggagacg tagagtttgt ctgcaaggtt     840

tacagtgatg cccagcccca catccagtgg atcaagcacg tggaaaagaa cggcagtaaa     900

tacgggcccg acgggctgcc ctacctcaag gttctcaagg ccgccggtgt taacaccacg     960

gacaaagaga ttgaggttct ctatattcgg aatgtaactt ttgaggacgc tggggaatat    1020

acgtgcttgg cgggtaattc tattgggata tcctttcact ctgcatggtt gacagttctg    1080

ccagcgcctg gaagagaaaa ggagattaca gcttccccag actacctgga gatagccatt    1140

tactgcatag gggtcttctt aatcgcctgt atggtggtaa cagtcatcct gtgccgaatg    1200

aagaacacga ccaagaagcc agacttcagc agccagccgg ctgtgcacaa gctgaccaaa    1260

cgtatccccc tgcggagaca ggtaacagtt tcggctgagt ccagctcctc catgaactcc    1320

aacaccccgc tggtgaggat aacaacacgc ctctcttcaa cggcagacac ccccatgctg    1380

gcaggggtct ccgagtatga acttccagag gacccaaaat gggagtttcc aagagataag    1440

ctgacactgg gcaagcccct gggagaaggt tgctttgggc aagtggtcat ggcggaagca    1500

gtgggaattg acaaagacaa gcccaaggag gcggtcaccg tggccgtgaa gatgttgaaa    1560

gatgatgcca cagagaaaga cctttctgat ctggtgtcag agatggagat gatgaagatg    1620

attgggaaac acaagaatat cataaatctt cttggagcct gcacacagga tgggcctctc    1680

tatgtcatag ttgagtatgc ctctaaaggc aacctccgag aatacctccg agcccggagg    1740

ccacccggga tggagtactc ctatgacatt aaccgtgttc ctgaggagca gatgaccttc    1800

aaggacttgg tgtcatgcac ctaccagctg gccagaggca tggagtactt ggcttcccaa    1860

aaatgtattc atcgagattt agcagccaga aatgttttgg taacagaaaa caatgtgatg    1920

aaaatagcag actttggact cgccagagat atcaacaata tagactatta caaaaagacc    1980

accaatgggc ggcttccagt caagtggatg gctccagaag ccctgtttga tagagtatac    2040

actcatcaga gtgatgtctg gtccttcggg gtgttaatgt gggagatctt cactttaggg    2100

ggctcgccct acccagggat tcccgtggag gaacttttta agctgctgaa ggaaggacac    2160

agaatggata agccagccaa ctgcaccaac gaactgtaca tgatgatgag ggactgttgg    2220

catgcagtgc cctcccagag accaacgttc aagcagttgg tagaagactt ggatcgaatt    2280

ctcactctca caaccaatga ggaatacttg gacctcagcc aacctctcga acagtattca    2340

cctagttacc ctgacacaag aagttcttgt tcttcaggag atgattctgt tttttctcca    2400

gaccccatgc cttacgaacc atgccttcct cagtatccac acataaacgg cagtgttaaa    2460

acatga                                                               2466


<210> 32
<211> 2523
<212> DNA
<213> Mus musculus

<220> 
<223> murine FGFR2

<400> 32
atgggattac cgtccacgtg gagatatgga agaggaccag ggattggcac tgtgaccatg      60

gtcagctggg ggcgcttcat ctgcctggtc ttggtcacca tggcaacctt gtccctggcc     120

cggccctcct tcagtttagt tgaggatacc actttagaac cagaagagcc accaaccaaa     180

taccaaatct cccaaccaga agcgtacgtg gttgcccccg gggaatcgct agagttgcag     240

tgcatgttga aagatgccgc cgtgatcagt tggactaagg atggggtgca cttggggccc     300

aacaatagga cagtgcttat tggggagtat ctccagataa aaggtgccac acctagagac     360

tccggcctct atgcttgtac tgcagctagg acggtagaca gtgaaacttg gtacttcatg     420

gtgaatgtca cagatgccat ctcatctgga gatgatgagg acgacacaga tagctccgaa     480

gacgttgtca gtgagaacag gagcaaccag agagcaccgt actggaccaa caccgagaag     540

atggagaagc ggctccacgc tgtccctgcc gccaacactg tgaagttccg ctgtccggct     600

ggggggaatc caacgcccac aatgaggtgg ttaaaaaacg ggaaggagtt taagcaggag     660

catcgcattg gaggctataa ggtacgaaac cagcactgga gccttattat ggaaagtgtg     720

gtcccgtcag acaaaggcaa ctacacctgc ctggtggaga atgaatacgg gtccatcaac     780

cacacctacc acctcgatgt cgttgaacgg tcaccacacc ggcccatcct ccaagctgga     840

ctgcctgcaa atgcctccac ggtggtcgga ggggatgtgg agtttgtctg caaggtttac     900

agcgatgccc agccccacat ccagtggatc aagcacgtgg aaaagaacgg cagtaaatac     960

gggcctgatg ggctgcccta cctcaaggtc ctgaaggccg ccggtgttaa caccacggac    1020

aaagagattg aggttctcta tattcggaat gtaacttttg aggatgctgg ggaatatacg    1080

tgcttggcgg gtaattctat cgggatatcc tttcactctg catggttgac agttctgcca    1140

gcgcctgtga gagagaagga gatcacggct tccccagatt atctggagat agctatttac    1200

tgcatagggg tcttcttaat cgcctgcatg gtggtgacag tcatcttttg ccgaatgaag    1260

accacgacca agaagccaga cttcagcagc cagccagctg tgcacaagct gaccaagcgc    1320

atccccctgc ggagacaggt aacagtttcg gccgagtcca gctcctccat gaactccaac    1380

accccgctgg tgaggataac aacgcgtctg tcctcaacag cggacacccc gatgctagca    1440

ggggtctccg agtatgagtt gccagaggat ccaaagtggg aattccccag agataagctg    1500

acgctgggca aacccctggg ggaaggttgc ttcgggcaag tagtcatggc tgaagcagtg    1560

ggaatcgata aagacaaacc caaggaggcg gtcaccgtgg cagtgaagat gttgaaagat    1620

gatgccacag agaaggacct gtctgatctg gtatcagaga tggagatgat gaagatgatt    1680

gggaaacata agaacattat caacctcctg ggggcctgca cgcaggatgg acctctctac    1740

gtcatagttg aatatgcatc gaaaggcaac ctccgggaat acctccgagc ccggaggcca    1800

cctggcatgg agtactccta tgacattaac cgtgtccccg aggagcagat gaccttcaag    1860

gacttggtgt cctgcaccta ccagctggct agaggcatgg agtacttggc ttcccaaaaa    1920

tgtatccatc gagatttggc tgccagaaac gtgttggtaa cagaaaacaa tgtgatgaag    1980

atagcagact ttggcctggc cagggatatc aacaacatag actactataa aaagaccaca    2040

aatgggcgac ttccagtcaa gtggatggct cctgaagccc tttttgatag agtttacact    2100

catcagagcg atgtctggtc cttcggggtg ttaatgtggg agatctttac tttagggggc    2160

tcaccctacc cagggattcc cgtggaggaa ctttttaagc tgctcaaaga gggacacagg    2220

atggacaagc ccaccaactg caccaatgaa ctgtacatga tgatgaggga ttgctggcat    2280

gctgtaccct cacagagacc cacattcaag cagttggtcg aagacttgga tcgaattctg    2340

actctcacaa ccaatgagga atacttggat ctcacccagc ctctcgaaca gtattctcct    2400

agttaccccg acacaaggag ctcttgttct tcaggggacg attctgtgtt ttctccagac    2460

cccatgcctt atgaaccctg tctgcctcag tatccacaca taaacggcag tgttaaaaca    2520

tga                                                                  2523


<210> 33
<211> 2421
<212> DNA
<213> Homo sapiens

<220> 
<223> human FGFR3

<400> 33
atgggcgccc ctgcctgcgc cctcgcgctc tgcgtggccg tggccatcgt ggccggcgcc      60

tcctcggagt ccttggggac ggagcagcgc gtcgtggggc gagcggcaga agtcccgggc     120

ccagagcccg gccagcagga gcagttggtc ttcggcagcg gggatgctgt ggagctgagc     180

tgtcccccgc ccgggggtgg tcccatgggg cccactgtct gggtcaagga tggcacaggg     240

ctggtgccct cggagcgtgt cctggtgggg ccccagcggc tgcaggtgct gaatgcctcc     300

cacgaggact ccggggccta cagctgccgg cagcggctca cgcagcgcgt actgtgccac     360

ttcagtgtgc gggtgacaga cgctccatcc tcgggagatg acgaagacgg ggaggacgag     420

gctgaggaca caggtgtgga cacaggggcc ccttactgga cacggcccga gcggatggac     480

aagaagctgc tggccgtgcc ggccgccaac accgtccgct tccgctgccc agccgctggc     540

aaccccactc cctccatctc ctggctgaag aacggcaggg agttccgcgg cgagcaccgc     600

attggaggca tcaagctgcg gcatcagcag tggagcctgg tcatggaaag cgtggtgccc     660

tcggaccgcg gcaactacac ctgcgtcgtg gagaacaagt ttggcagcat ccggcagacg     720

tacacgctgg acgtgctgga gcgctccccg caccggccca tcctgcaggc ggggctgccg     780

gccaaccaga cggcggtgct gggcagcgac gtggagttcc actgcaaggt gtacagtgac     840

gcacagcccc acatccagtg gctcaagcac gtggaggtga atggcagcaa ggtgggcccg     900

gacggcacac cctacgttac cgtgctcaag acggcgggcg ctaacaccac cgacaaggag     960

ctagaggttc tctccttgca caacgtcacc tttgaggacg ccggggagta cacctgcctg    1020

gcgggcaatt ctattgggtt ttctcatcac tctgcgtggc tggtggtgct gccagccgag    1080

gaggagctgg tggaggctga cgaggcgggc agtgtgtatg caggcatcct cagctacggg    1140

gtgggcttct tcctgttcat cctggtggtg gcggctgtga cgctctgccg cctgcgcagc    1200

ccccccaaga aaggcctggg ctcccccacc gtgcacaaga tctcccgctt cccgctcaag    1260

cgacaggtgt ccctggagtc caacgcgtcc atgagctcca acacaccact ggtgcgcatc    1320

gcaaggctgt cctcagggga gggccccacg ctggccaatg tctccgagct cgagctgcct    1380

gccgacccca aatgggagct gtctcgggcc cggctgaccc tgggcaagcc ccttggggag    1440

ggctgcttcg gccaggtggt catggcggag gccatcggca ttgacaagga ccgggccgcc    1500

aagcctgtca ccgtagccgt gaagatgctg aaagacgatg ccactgacaa ggacctgtcg    1560

gacctggtgt ctgagatgga gatgatgaag atgatcggga aacacaaaaa catcatcaac    1620

ctgctgggcg cctgcacgca gggcgggccc ctgtacgtgc tggtggagta cgcggccaag    1680

ggtaacctgc gggagtttct gcgggcgcgg cggcccccgg gcctggacta ctccttcgac    1740

acctgcaagc cgcccgagga gcagctcacc ttcaaggacc tggtgtcctg tgcctaccag    1800

gtggcccggg gcatggagta cttggcctcc cagaagtgca tccacaggga cctggctgcc    1860

cgcaatgtgc tggtgaccga ggacaacgtg atgaagatcg cagacttcgg gctggcccgg    1920

gacgtgcaca acctcgacta ctacaagaag acgaccaacg gccggctgcc cgtgaagtgg    1980

atggcgcctg aggccttgtt tgaccgagtc tacactcacc agagtgacgt ctggtccttt    2040

ggggtcctgc tctgggagat cttcacgctg gggggctccc cgtaccccgg catccctgtg    2100

gaggagctct tcaagctgct gaaggagggc caccgcatgg acaagcccgc caactgcaca    2160

cacgacctgt acatgatcat gcgggagtgc tggcatgccg cgccctccca gaggcccacc    2220

ttcaagcagc tggtggagga cctggaccgt gtccttaccg tgacgtccac cgacgagtac    2280

ctggacctgt cggcgccttt cgagcagtac tccccgggtg gccaggacac ccccagctcc    2340

agctcctcag gggacgactc cgtgtttgcc cacgacctgc tgcccccggc cccacccagc    2400

agtgggggct cgcggacgtg a                                              2421


<210> 34
<211> 2349
<212> DNA
<213> Mus musculus

<220> 
<223> murine FGFR3

<400> 34
atggtagtcc cggcctgcgt gctagtgttc tgcgtggcgg tcgtggctgg agctacttcc      60

gagcctcctg gtccagagca gcgagttgtg cggagagcgg cagaggttcc agggcctgaa     120

cctagccagc aggagcaggt ggccttcggc agtggggaca ccgtggagct gagctgccat     180

cctcctggag gtgcccccac agggcccacg gtctgggcta aggatggtac aggtctggtg     240

gcctcccacc gcatcctggt ggggcctcag aggctgcaag tgctaaatgc ctcccacgaa     300

gatgcagggg tctacagctg ccagcaccgg ctcactcggc gtgtgctgtg ccacttcagt     360

gtgcgtgtaa caggggctcc ttattggact cgcccggagc gaatggataa gaaactgctg     420

gctgtgccag ccgcaaacac tgtccgcttc cgctgcccag ctgctggcaa ccctaccccc     480

tccatctcct ggctgaagaa tggcaaagaa ttccgagggg agcatcgcat tgggggcatc     540

aagctccggc accagcagtg gagcttggtc atggaaagtg tggtaccctc cgatcgtggc     600

aactatacct gtgtagttga gaacaagttt ggcagcatcc ggcagacata cacactggat     660

gtgctggagc gctccccaca ccggcccatc ctgcaggctg ggctgccggc caaccagaca     720

gccattctag gcagtgacgt ggagttccac tgcaaggtgt acagcgatgc acagccacac     780

atccagtggc tgaagcacgt ggaagtgaac ggcagcaagg tgggccctga cggcacgccc     840

tacgtcactg tactcaagac tgcaggcgct aacaccaccg acaaggagct agaggttctg     900

tccttgcaca atgtcacctt tgaggacgcg ggggagtaca cctgcctggc gggcaattct     960

attgggtttt cccatcactc tgcgtggctg gtggtgctgc cagctgagga ggagctgatg    1020

gaaactgatg aggctggcag cgtgtacgca ggcgtcctca gctacggggt ggtcttcttc    1080

ctcttcatcc tggtggtggc agctgtgata ctctgccgcc tgcgcagtcc cccaaagaag    1140

ggcttgggct cgcccaccgt gcacaaggtc tctcgcttcc cgcttaagcg acaggtgtcc    1200

ttggaatcta actcctctat gaactccaac acaccccttg tccggattgc ccggctgtcc    1260

tcaggagaag gtcctgttct ggccaatgtt tctgaacttg agctgcctgc tgaccccaag    1320

tgggagctat ccaggacccg gctgacactt ggtaagcctc ttggagaagg ctgctttgga    1380

caggtggtca tggcagaagc tattggcatc gacaaggacc gtactgccaa gcctgtcacc    1440

gtggccgtga agatgctgaa agatgatgcg actgacaagg acctgtcgga cctggtatct    1500

gagatggaga tgatgaaaat gattggcaag cacaagaaca tcattaacct gctgggggcg    1560

tgcacacagg gtgggcccct gtatgtgctg gtggagtacg cagccaaggg caatctccgg    1620

gagttccttc gggcgcggcg gcctccaggc atggactact cctttgatgc ctgcaggctg    1680

ccagaggaac agctcacctg caaggatcta gtgtcctgtg cctaccaggt ggcacggggc    1740

atggaatact tggcttctca gaagtgtatt cacagagact tggctgccag aaacgtcctg    1800

gtgaccgagg acaatgtgat gaagattgcg gactttggcc tggctcgaga tgtgcacaac    1860

ctggactact acaagaagac cacaaatggc cggctacctg tgaagtggat ggcaccagag    1920

gccctttttg accgagtcta cacccaccag agtgatgttt ggtcttttgg tgtcctcctc    1980

tgggagatct ttacgctggg gggctcaccg tatcctggca tcccagtgga agagcttttc    2040

aagctgttga aagagggcca ccgcatggac aagccagcca gctgcacaca tgacctgtac    2100

atgatcatgc gggaatgttg gcatgcggtg ccttcacaga ggcccacctt caagcagttg    2160

gtagaggatt tagaccgcat cctcactgtg acatcaaccg acgagtactt ggacctctcc    2220

gtgccgtttg agcagtactc gccaggtggc caggacacgc ctagctccag ctcgtccgga    2280

gatgactcgg tgttcaccca tgacctgcta cccccaggtc cacccagtaa cgggggacct    2340

cggacgtga                                                            2349


<210> 35
<211> 2409
<212> DNA
<213> Homo sapiens

<220> 
<223> human FGFR4

<400> 35
atgcggctgc tgctggccct gttgggggtc ctgctgagtg tgcctgggcc tccagtcttg      60

tccctggagg cctctgagga agtggagctt gagccctgcc tggctcccag cctggagcag     120

caagagcagg agctgacagt agcccttggg cagcctgtgc gtctgtgctg tgggcgggct     180

gagcgtggtg gccactggta caaggagggc agtcgcctgg cacctgctgg ccgtgtacgg     240

ggctggaggg gccgcctaga gattgccagc ttcctacctg aggatgctgg ccgctacctc     300

tgcctggcac gaggctccat gatcgtcctg cagaatctca ccttgattac aggtgactcc     360

ttgacctcca gcaacgatga tgaggacccc aagtcccata gggacccctc gaataggcac     420

agttaccccc agcaagcacc ctactggaca cacccccagc gcatggagaa gaaactgcat     480

gcagtacctg cggggaacac cgtcaagttc cgctgtccag ctgcaggcaa ccccacgccc     540

accatccgct ggcttaagga tggacaggcc tttcatgggg agaaccgcat tggaggcatt     600

cggctgcgcc atcagcactg gagtctcgtg atggagagcg tggtgccctc ggaccgcggc     660

acatacacct gcctggtaga gaacgctgtg ggcagcatcc gctataacta cctgctagat     720

gtgctggagc ggtccccgca ccggcccatc ctgcaggccg ggctcccggc caacaccaca     780

gccgtggtgg gcagcgacgt ggagctgctg tgcaaggtgt acagcgatgc ccagccccac     840

atccagtggc tgaagcacat cgtcatcaac ggcagcagct tcggagccga cggtttcccc     900

tatgtgcaag tcctaaagac tgcagacatc aatagctcag aggtggaggt cctgtacctg     960

cggaacgtgt cagccgagga cgcaggcgag tacacctgcc tcgcaggcaa ttccatcggc    1020

ctctcctacc agtctgcctg gctcacggtg ctgccagagg aggaccccac atggaccgca    1080

gcagcgcccg aggccaggta tacggacatc atcctgtacg cgtcgggctc cctggccttg    1140

gctgtgctcc tgctgctggc cgggctgtat cgagggcagg cgctccacgg ccggcacccc    1200

cgcccgcccg ccactgtgca gaagctctcc cgcttccctc tggcccgaca gttctccctg    1260

gagtcaggct cttccggcaa gtcaagctca tccctggtac gaggcgtgcg tctctcctcc    1320

agcggccccg ccttgctcgc cggcctcgtg agtctagatc tacctctcga cccactatgg    1380

gagttccccc gggacaggct ggtgcttggg aagcccctag gcgagggctg ctttggccag    1440

gtagtacgtg cagaggcctt tggcatggac cctgcccggc ctgaccaagc cagcactgtg    1500

gccgtcaaga tgctcaaaga caacgcctct gacaaggacc tggccgacct ggtctcggag    1560

atggaggtga tgaagctgat cggccgacac aagaacatca tcaacctgct tggtgtctgc    1620

acccaggaag ggcccctgta cgtgatcgtg gagtgcgccg ccaagggaaa cctgcgggag    1680

ttcctgcggg cccggcgccc cccaggcccc gacctcagcc ccgacggtcc tcggagcagt    1740

gaggggccgc tctccttccc agtcctggtc tcctgcgcct accaggtggc ccgaggcatg    1800

cagtatctgg agtcccggaa gtgtatccac cgggacctgg ctgcccgcaa tgtgctggtg    1860

actgaggaca atgtgatgaa gattgctgac tttgggctgg cccgcggcgt ccaccacatt    1920

gactactata agaaaaccag caacggccgc ctgcctgtga agtggatggc gcccgaggcc    1980

ttgtttgacc gggtgtacac acaccagagt gacgtgtggt cttttgggat cctgctatgg    2040

gagatcttca ccctcggggg ctccccgtat cctggcatcc cggtggagga gctgttctcg    2100

ctgctgcggg agggacatcg gatggaccga cccccacact gccccccaga gctgtacggg    2160

ctgatgcgtg agtgctggca cgcagcgccc tcccagaggc ctaccttcaa gcagctggtg    2220

gaggcgctgg acaaggtcct gctggccgtc tctgaggagt acctcgacct ccgcctgacc    2280

ttcggaccct attccccctc tggtggggac gccagcagca cctgctcctc cagcgattct    2340

gtcttcagcc acgaccccct gccattggga tccagctcct tccccttcgg gtctggggtg    2400

cagacatga                                                            2409


<210> 36
<211> 2400
<212> DNA
<213> Mus musculus

<220> 
<223> murine FGFR4

<400> 36
atgtggctgc tcttggccct gttgagcatc tttcagggga caccagcttt gtcccttgag      60

gcctctgagg aaatggagca ggagccctgc ctagccccaa tcctggagca gcaagagcag     120

gtgttgacgg tggccctggg gcagcctgtg aggctgtgct gtgggcgcac cgagcgtggt     180

cgtcactggt acaaagaggg cagccgccta gcatctgctg ggcgagtacg gggttggaga     240

ggccgcctgg agatcgccag cttccttcct gaggatgctg gccgatacct ctgcctggcc     300

cgtggctcca tgaccgtcgt acacaatctt acgttgctta tggatgactc cttaacctcc     360

atcagtaatg atgaagaccc caagacactc agcagctcct cgagtggtca tgtctaccca     420

cagcaagcac cctactggac acacccccaa cgcatggaga agaaactgca tgcagtgcct     480

gccgggaata ctgtcaaatt ccgctgtcca gctgcaggga accccatgcc taccatccac     540

tggctcaagg atggacaggc cttccacggg gagaatcgta ttggaggcat tcggctgcgc     600

caccaacact ggagcctggt gatggaaagt gtggtaccct cggaccgtgg cacatacaca     660

tgccttgtgg agaactctct gggtagcatt cgctacagct atctcctgga tgtgctggag     720

cggtccccgc accggcccat cctgcaggcg gggctcccag ccaacaccac agctgtggtt     780

ggcagcgatg tggagctact ctgcaaggtg tacagcgacg cccagcccca catacagtgg     840

ctgaaacacg tcgtcatcaa cggcagcagc ttcggcgccg acggtttccc ctacgtacaa     900

gtcctgaaga caacagacat caatagctcg gaggtagagg tcttgtatct gaggaacgtg     960

tccgctgagg atgcaggaga gtatacctgt ctggcgggca actccatcgg cctttcctac    1020

cagtcagcgt ggctcacggt gctgccagag gaagacctca cgtggacaac agcaacccct    1080

gaggccagat acacagatat catcctgtat gtatcaggct cactggttct gcttgtgctc    1140

ctgctgctgg ccggggtgta tcatcggcaa gtcatccgtg gccactactc tcgccagcct    1200

gtcactatac aaaagctgtc ccgtttccct ttggcccgac agttctcttt ggagtcgagg    1260

tcctctggca agtcaagttt gtccctggtg cgaggtgtcc gtctctcctc cagcggcccg    1320

cccttgctca cgggccttgt gaatctagac ctgcctctcg atccgctttg ggaattcccc    1380

cgggacaggt tggtgctcgg aaagcccctg ggtgagggct gctttgggca agtggttcgt    1440

gcagaggcct ttggtatgga tccctcccgg cccgaccaaa ccagcaccgt ggctgtgaag    1500

atgctgaaag acaatgcctc cgacaaggat ttggcagacc tggtctccga gatggaggtg    1560

atgaagctaa tcggaagaca caagaacatc atcaacctgc tgggtgtctg cactcaggaa    1620

gggcccctgt acgtgattgt ggaatgtgcc gccaagggaa accttcggga attcctccgt    1680

gcccggcgcc ccccaggccc tgatctcagc cctgatggac ctcggagcag cgaaggacca    1740

ctctccttcc cggccctagt ctcctgtgcc taccaggtgg cccgaggcat gcagtatctg    1800

gagtctcgga agtgcatcca ccgggacctg gctgcccgaa atgtgctggt gaccgaggat    1860

gatgtgatga agatcgctga ctttgggctg gcacgtggtg tccaccacat tgactactat    1920

aagaaaacca gcaacggccg cctgccagtc aaatggatgg ctccagaggc attgttcgac    1980

cgcgtgtaca cacaccagag tgacgtgtgg tctttcggga tcctgctgtg ggaaatcttc    2040

accctcgggg gctccccata ccctggcatt ccggtggagg agctcttctc actgctgcga    2100

gaggggcaca ggatggagcg gcccccaaac tgcccctcag agctgtatgg gctaatgagg    2160

gagtgctggc acgcagcccc atctcagagg cctactttta agcagctggt ggaagctctg    2220

gacaaggtcc tgctggctgt ctctgaagag taccttgacc tccgcctgac ctttggaccc    2280

ttttctccct ccaatgggga tgccagcagc acctgctcct ccagtgactc ggttttcagc    2340

cacgaccctt tgcccctcga gccaagcccc ttccctttct ctgactcgca gacgacatga    2400


<210> 37
<400> 37
000

<210> 38
<400> 38
000

<210> 39
<400> 39
000

<210> 40
<400> 40
000

<210> 41
<400> 41
000

<210> 42
<400> 42
000

<210> 43
<211> 820
<212> PRT
<213> Homo sapiens

<220> 
<223> human FGFR1

<400> 43
Met Trp Ser Trp Lys Cys Leu Leu Phe Trp Ala Val Leu Val Thr Ala 
1               5                   10                  15      
Thr Leu Cys Thr Ala Arg Pro Ser Pro Thr Leu Pro Glu Gln Ala Gln 
            20                  25                  30          
Pro Trp Gly Ala Pro Val Glu Val Glu Ser Phe Leu Val His Pro Gly 
        35                  40                  45              
Asp Leu Leu Gln Leu Arg Cys Arg Leu Arg Asp Asp Val Gln Ser Ile 
    50                  55                  60                  
Asn Trp Leu Arg Asp Gly Val Gln Leu Ala Glu Ser Asn Arg Thr Arg 
65                  70                  75                  80  
Ile Thr Gly Glu Glu Val Glu Val Gln Asp Ser Val Pro Ala Asp Ser 
                85                  90                  95      
Gly Leu Tyr Ala Cys Val Thr Ser Ser Pro Ser Gly Ser Asp Thr Thr 
            100                 105                 110         
Tyr Phe Ser Val Asn Val Ser Asp Ala Leu Pro Ser Ser Glu Asp Asp 
        115                 120                 125             
Asp Asp Asp Asp Asp Ser Ser Ser Glu Glu Lys Glu Thr Asp Asn Thr 
    130                 135                 140                 
Lys Pro Asn Pro Val Ala Pro Tyr Trp Thr Ser Pro Glu Lys Met Glu 
145                 150                 155                 160 
Lys Lys Leu His Ala Val Pro Ala Ala Lys Thr Val Lys Phe Lys Cys 
                165                 170                 175     
Pro Ser Ser Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu Lys Asn Gly 
            180                 185                 190         
Lys Glu Phe Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val Arg Tyr 
        195                 200                 205             
Ala Thr Trp Ser Ile Ile Met Asp Ser Val Val Pro Ser Asp Lys Gly 
    210                 215                 220                 
Asn Tyr Thr Cys Ile Val Glu Asn Glu Tyr Gly Ser Ile Asn His Thr 
225                 230                 235                 240 
Tyr Gln Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile Leu Gln 
                245                 250                 255     
Ala Gly Leu Pro Ala Asn Lys Thr Val Ala Leu Gly Ser Asn Val Glu 
            260                 265                 270         
Phe Met Cys Lys Val Tyr Ser Asp Pro Gln Pro His Ile Gln Trp Leu 
        275                 280                 285             
Lys His Ile Glu Val Asn Gly Ser Lys Ile Gly Pro Asp Asn Leu Pro 
    290                 295                 300                 
Tyr Val Gln Ile Leu Lys Thr Ala Gly Val Asn Thr Thr Asp Lys Glu 
305                 310                 315                 320 
Met Glu Val Leu His Leu Arg Asn Val Ser Phe Glu Asp Ala Gly Glu 
                325                 330                 335     
Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu Ser His His Ser Ala 
            340                 345                 350         
Trp Leu Thr Val Leu Glu Ala Leu Glu Glu Arg Pro Ala Val Met Thr 
        355                 360                 365             
Ser Pro Leu Tyr Leu Glu Ile Ile Ile Tyr Cys Thr Gly Ala Phe Leu 
    370                 375                 380                 
Ile Ser Cys Met Val Gly Ser Val Ile Val Tyr Lys Met Lys Ser Gly 
385                 390                 395                 400 
Thr Lys Lys Ser Asp Phe His Ser Gln Met Ala Val His Lys Leu Ala 
                405                 410                 415     
Lys Ser Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala Asp Ser Ser 
            420                 425                 430         
Ala Ser Met Asn Ser Gly Val Leu Leu Val Arg Pro Ser Arg Leu Ser 
        435                 440                 445             
Ser Ser Gly Thr Pro Met Leu Ala Gly Val Ser Glu Tyr Glu Leu Pro 
    450                 455                 460                 
Glu Asp Pro Arg Trp Glu Leu Pro Arg Asp Arg Leu Val Leu Gly Lys 
465                 470                 475                 480 
Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Leu Ala Glu Ala Ile 
                485                 490                 495     
Gly Leu Asp Lys Asp Lys Pro Asn Arg Val Thr Lys Val Ala Val Lys 
            500                 505                 510         
Met Leu Lys Ser Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu Ile Ser 
        515                 520                 525             
Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn 
    530                 535                 540                 
Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile Val Glu 
545                 550                 555                 560 
Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu Gln Ala Arg Arg Pro 
                565                 570                 575     
Pro Gly Leu Glu Tyr Cys Tyr Asn Pro Ser His Asn Pro Glu Glu Gln 
            580                 585                 590         
Leu Ser Ser Lys Asp Leu Val Ser Cys Ala Tyr Gln Val Ala Arg Gly 
        595                 600                 605             
Met Glu Tyr Leu Ala Ser Lys Lys Cys Ile His Arg Asp Leu Ala Ala 
    610                 615                 620                 
Arg Asn Val Leu Val Thr Glu Asp Asn Val Met Lys Ile Ala Asp Phe 
625                 630                 635                 640 
Gly Leu Ala Arg Asp Ile His His Ile Asp Tyr Tyr Lys Lys Thr Thr 
                645                 650                 655     
Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp 
            660                 665                 670         
Arg Ile Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu 
        675                 680                 685             
Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Val Pro Val 
    690                 695                 700                 
Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro 
705                 710                 715                 720 
Ser Asn Cys Thr Asn Glu Leu Tyr Met Met Met Arg Asp Cys Trp His 
                725                 730                 735     
Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu 
            740                 745                 750         
Asp Arg Ile Val Ala Leu Thr Ser Asn Gln Glu Tyr Leu Asp Leu Ser 
        755                 760                 765             
Met Pro Leu Asp Gln Tyr Ser Pro Ser Phe Pro Asp Thr Arg Ser Ser 
    770                 775                 780                 
Thr Cys Ser Ser Gly Glu Asp Ser Val Phe Ser His Glu Pro Leu Pro 
785                 790                 795                 800 
Glu Glu Pro Cys Leu Pro Arg His Pro Ala Gln Leu Ala Asn Gly Gly 
                805                 810                 815     
Leu Lys Arg Arg 
            820 

<210> 44
<211> 822
<212> PRT
<213> Mus musculus

<220> 
<223> murine FGFR1

<400> 44
Met Trp Gly Trp Lys Cys Leu Leu Phe Trp Ala Val Leu Val Thr Ala 
1               5                   10                  15      
Thr Leu Cys Thr Ala Arg Pro Ala Pro Thr Leu Pro Glu Gln Ala Gln 
            20                  25                  30          
Pro Trp Gly Val Pro Val Glu Val Glu Ser Leu Leu Val His Pro Gly 
        35                  40                  45              
Asp Leu Leu Gln Leu Arg Cys Arg Leu Arg Asp Asp Val Gln Ser Ile 
    50                  55                  60                  
Asn Trp Leu Arg Asp Gly Val Gln Leu Val Glu Ser Asn Arg Thr Arg 
65                  70                  75                  80  
Ile Thr Gly Glu Glu Val Glu Val Arg Asp Ser Ile Pro Ala Asp Ser 
                85                  90                  95      
Gly Leu Tyr Ala Cys Val Thr Ser Ser Pro Ser Gly Ser Asp Thr Thr 
            100                 105                 110         
Tyr Phe Ser Val Asn Val Ser Asp Ala Leu Pro Ser Ser Glu Asp Asp 
        115                 120                 125             
Asp Asp Asp Asp Asp Ser Ser Ser Glu Glu Lys Glu Thr Asp Asn Thr 
    130                 135                 140                 
Lys Pro Asn Arg Arg Pro Val Ala Pro Tyr Trp Thr Ser Pro Glu Lys 
145                 150                 155                 160 
Met Glu Lys Lys Leu His Ala Val Pro Ala Ala Lys Thr Val Lys Phe 
                165                 170                 175     
Lys Cys Pro Ser Ser Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu Lys 
            180                 185                 190         
Asn Gly Lys Glu Phe Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val 
        195                 200                 205             
Arg Tyr Ala Thr Trp Ser Ile Ile Met Asp Ser Val Val Pro Ser Asp 
    210                 215                 220                 
Lys Gly Asn Tyr Thr Cys Ile Val Glu Asn Glu Tyr Gly Ser Ile Asn 
225                 230                 235                 240 
His Thr Tyr Gln Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile 
                245                 250                 255     
Leu Gln Ala Gly Leu Pro Ala Asn Lys Thr Val Ala Leu Gly Ser Asn 
            260                 265                 270         
Val Glu Phe Met Cys Lys Val Tyr Ser Asp Pro Gln Pro His Ile Gln 
        275                 280                 285             
Trp Leu Lys His Ile Glu Val Asn Gly Ser Lys Ile Gly Pro Asp Asn 
    290                 295                 300                 
Leu Pro Tyr Val Gln Ile Leu Lys Thr Ala Gly Val Asn Thr Thr Asp 
305                 310                 315                 320 
Lys Glu Met Glu Val Leu His Leu Arg Asn Val Ser Phe Glu Asp Ala 
                325                 330                 335     
Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu Ser His His 
            340                 345                 350         
Ser Ala Trp Leu Thr Val Leu Glu Ala Leu Glu Glu Arg Pro Ala Val 
        355                 360                 365             
Met Thr Ser Pro Leu Tyr Leu Glu Ile Ile Ile Tyr Cys Thr Gly Ala 
    370                 375                 380                 
Phe Leu Ile Ser Cys Met Leu Gly Ser Val Ile Ile Tyr Lys Met Lys 
385                 390                 395                 400 
Ser Gly Thr Lys Lys Ser Asp Phe His Ser Gln Met Ala Val His Lys 
                405                 410                 415     
Leu Ala Lys Ser Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala Asp 
            420                 425                 430         
Ser Ser Ala Ser Met Asn Ser Gly Val Leu Leu Val Arg Pro Ser Arg 
        435                 440                 445             
Leu Ser Ser Ser Gly Thr Pro Met Leu Ala Gly Val Ser Glu Tyr Glu 
    450                 455                 460                 
Leu Pro Glu Asp Pro Arg Trp Glu Leu Pro Arg Asp Arg Leu Val Leu 
465                 470                 475                 480 
Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Leu Ala Glu 
                485                 490                 495     
Ala Ile Gly Leu Asp Lys Asp Lys Pro Asn Arg Val Thr Lys Val Ala 
            500                 505                 510         
Val Lys Met Leu Lys Ser Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu 
        515                 520                 525             
Ile Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys Asn Ile 
    530                 535                 540                 
Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile 
545                 550                 555                 560 
Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu Gln Ala Arg 
                565                 570                 575     
Arg Pro Pro Gly Leu Glu Tyr Cys Tyr Asn Pro Ser His Asn Pro Glu 
            580                 585                 590         
Glu Gln Leu Ser Ser Lys Asp Leu Val Ser Cys Ala Tyr Gln Val Ala 
        595                 600                 605             
Arg Gly Met Glu Tyr Leu Ala Ser Lys Lys Cys Ile His Arg Asp Leu 
    610                 615                 620                 
Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn Val Met Lys Ile Ala 
625                 630                 635                 640 
Asp Phe Gly Leu Ala Arg Asp Ile His His Ile Asp Tyr Tyr Lys Lys 
                645                 650                 655     
Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu 
            660                 665                 670         
Phe Asp Arg Ile Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Val 
        675                 680                 685             
Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Val 
    690                 695                 700                 
Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp 
705                 710                 715                 720 
Lys Pro Ser Asn Cys Thr Asn Glu Leu Tyr Met Met Met Arg Asp Cys 
                725                 730                 735     
Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu 
            740                 745                 750         
Asp Leu Asp Arg Ile Val Ala Leu Thr Ser Asn Gln Glu Tyr Leu Asp 
        755                 760                 765             
Leu Ser Ile Pro Leu Asp Gln Tyr Ser Pro Ser Phe Pro Asp Thr Arg 
    770                 775                 780                 
Ser Ser Thr Cys Ser Ser Gly Glu Asp Ser Val Phe Ser His Glu Pro 
785                 790                 795                 800 
Leu Pro Glu Glu Pro Cys Leu Pro Arg His Pro Thr Gln Leu Ala Asn 
                805                 810                 815     
Ser Gly Leu Lys Arg Arg 
            820         

<210> 45
<211> 821
<212> PRT
<213> Homo sapiens

<220> 
<223> human FGFR2

<400> 45
Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala 
1               5                   10                  15      
Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr 
            20                  25                  30          
Leu Glu Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu 
        35                  40                  45              
Val Tyr Val Ala Ala Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu 
    50                  55                  60                  
Lys Asp Ala Ala Val Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly 
65                  70                  75                  80  
Pro Asn Asn Arg Thr Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly 
                85                  90                  95      
Ala Thr Pro Arg Asp Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr 
            100                 105                 110         
Val Asp Ser Glu Thr Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile 
        115                 120                 125             
Ser Ser Gly Asp Asp Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val 
    130                 135                 140                 
Ser Glu Asn Ser Asn Asn Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu 
145                 150                 155                 160 
Lys Met Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys 
                165                 170                 175     
Phe Arg Cys Pro Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu 
            180                 185                 190         
Lys Asn Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys 
        195                 200                 205             
Val Arg Asn Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser 
    210                 215                 220                 
Asp Lys Gly Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile 
225                 230                 235                 240 
Asn His Thr Tyr His Leu Asp Val Val Glu Arg Ser Pro His Arg Pro 
                245                 250                 255     
Ile Leu Gln Ala Gly Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly 
            260                 265                 270         
Asp Val Glu Phe Val Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile 
        275                 280                 285             
Gln Trp Ile Lys His Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp 
    290                 295                 300                 
Gly Leu Pro Tyr Leu Lys Val Leu Lys Ala Ala Gly Val Asn Thr Thr 
305                 310                 315                 320 
Asp Lys Glu Ile Glu Val Leu Tyr Ile Arg Asn Val Thr Phe Glu Asp 
                325                 330                 335     
Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Ile Ser Phe 
            340                 345                 350         
His Ser Ala Trp Leu Thr Val Leu Pro Ala Pro Gly Arg Glu Lys Glu 
        355                 360                 365             
Ile Thr Ala Ser Pro Asp Tyr Leu Glu Ile Ala Ile Tyr Cys Ile Gly 
    370                 375                 380                 
Val Phe Leu Ile Ala Cys Met Val Val Thr Val Ile Leu Cys Arg Met 
385                 390                 395                 400 
Lys Asn Thr Thr Lys Lys Pro Asp Phe Ser Ser Gln Pro Ala Val His 
                405                 410                 415     
Lys Leu Thr Lys Arg Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala 
            420                 425                 430         
Glu Ser Ser Ser Ser Met Asn Ser Asn Thr Pro Leu Val Arg Ile Thr 
        435                 440                 445             
Thr Arg Leu Ser Ser Thr Ala Asp Thr Pro Met Leu Ala Gly Val Ser 
    450                 455                 460                 
Glu Tyr Glu Leu Pro Glu Asp Pro Lys Trp Glu Phe Pro Arg Asp Lys 
465                 470                 475                 480 
Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val 
                485                 490                 495     
Met Ala Glu Ala Val Gly Ile Asp Lys Asp Lys Pro Lys Glu Ala Val 
            500                 505                 510         
Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Glu Lys Asp Leu 
        515                 520                 525             
Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His 
    530                 535                 540                 
Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu 
545                 550                 555                 560 
Tyr Val Ile Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu 
                565                 570                 575     
Arg Ala Arg Arg Pro Pro Gly Met Glu Tyr Ser Tyr Asp Ile Asn Arg 
            580                 585                 590         
Val Pro Glu Glu Gln Met Thr Phe Lys Asp Leu Val Ser Cys Thr Tyr 
        595                 600                 605             
Gln Leu Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile His 
    610                 615                 620                 
Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asn Asn Val Met 
625                 630                 635                 640 
Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile Asn Asn Ile Asp Tyr 
                645                 650                 655     
Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro 
            660                 665                 670         
Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser 
        675                 680                 685             
Phe Gly Val Leu Met Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr 
    690                 695                 700                 
Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His 
705                 710                 715                 720 
Arg Met Asp Lys Pro Ala Asn Cys Thr Asn Glu Leu Tyr Met Met Met 
                725                 730                 735     
Arg Asp Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln 
            740                 745                 750         
Leu Val Glu Asp Leu Asp Arg Ile Leu Thr Leu Thr Thr Asn Glu Glu 
        755                 760                 765             
Tyr Leu Asp Leu Ser Gln Pro Leu Glu Gln Tyr Ser Pro Ser Tyr Pro 
    770                 775                 780                 
Asp Thr Arg Ser Ser Cys Ser Ser Gly Asp Asp Ser Val Phe Ser Pro 
785                 790                 795                 800 
Asp Pro Met Pro Tyr Glu Pro Cys Leu Pro Gln Tyr Pro His Ile Asn 
                805                 810                 815     
Gly Ser Val Lys Thr 
            820     

<210> 46
<211> 840
<212> PRT
<213> Mus musculus

<220> 
<223> murine FGFR2

<400> 46
Met Gly Leu Pro Ser Thr Trp Arg Tyr Gly Arg Gly Pro Gly Ile Gly 
1               5                   10                  15      
Thr Val Thr Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Leu Val 
            20                  25                  30          
Thr Met Ala Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu 
        35                  40                  45              
Asp Thr Thr Leu Glu Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser 
    50                  55                  60                  
Gln Pro Glu Ala Tyr Val Val Ala Pro Gly Glu Ser Leu Glu Leu Gln 
65                  70                  75                  80  
Cys Met Leu Lys Asp Ala Ala Val Ile Ser Trp Thr Lys Asp Gly Val 
                85                  90                  95      
His Leu Gly Pro Asn Asn Arg Thr Val Leu Ile Gly Glu Tyr Leu Gln 
            100                 105                 110         
Ile Lys Gly Ala Thr Pro Arg Asp Ser Gly Leu Tyr Ala Cys Thr Ala 
        115                 120                 125             
Ala Arg Thr Val Asp Ser Glu Thr Trp Tyr Phe Met Val Asn Val Thr 
    130                 135                 140                 
Asp Ala Ile Ser Ser Gly Asp Asp Glu Asp Asp Thr Asp Ser Ser Glu 
145                 150                 155                 160 
Asp Val Val Ser Glu Asn Arg Ser Asn Gln Arg Ala Pro Tyr Trp Thr 
                165                 170                 175     
Asn Thr Glu Lys Met Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn 
            180                 185                 190         
Thr Val Lys Phe Arg Cys Pro Ala Gly Gly Asn Pro Thr Pro Thr Met 
        195                 200                 205             
Arg Trp Leu Lys Asn Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly 
    210                 215                 220                 
Gly Tyr Lys Val Arg Asn Gln His Trp Ser Leu Ile Met Glu Ser Val 
225                 230                 235                 240 
Val Pro Ser Asp Lys Gly Asn Tyr Thr Cys Leu Val Glu Asn Glu Tyr 
                245                 250                 255     
Gly Ser Ile Asn His Thr Tyr His Leu Asp Val Val Glu Arg Ser Pro 
            260                 265                 270         
His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Ala Ser Thr Val 
        275                 280                 285             
Val Gly Gly Asp Val Glu Phe Val Cys Lys Val Tyr Ser Asp Ala Gln 
    290                 295                 300                 
Pro His Ile Gln Trp Ile Lys His Val Glu Lys Asn Gly Ser Lys Tyr 
305                 310                 315                 320 
Gly Pro Asp Gly Leu Pro Tyr Leu Lys Val Leu Lys Ala Ala Gly Val 
                325                 330                 335     
Asn Thr Thr Asp Lys Glu Ile Glu Val Leu Tyr Ile Arg Asn Val Thr 
            340                 345                 350         
Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly 
        355                 360                 365             
Ile Ser Phe His Ser Ala Trp Leu Thr Val Leu Pro Ala Pro Val Arg 
    370                 375                 380                 
Glu Lys Glu Ile Thr Ala Ser Pro Asp Tyr Leu Glu Ile Ala Ile Tyr 
385                 390                 395                 400 
Cys Ile Gly Val Phe Leu Ile Ala Cys Met Val Val Thr Val Ile Phe 
                405                 410                 415     
Cys Arg Met Lys Thr Thr Thr Lys Lys Pro Asp Phe Ser Ser Gln Pro 
            420                 425                 430         
Ala Val His Lys Leu Thr Lys Arg Ile Pro Leu Arg Arg Gln Val Thr 
        435                 440                 445             
Val Ser Ala Glu Ser Ser Ser Ser Met Asn Ser Asn Thr Pro Leu Val 
    450                 455                 460                 
Arg Ile Thr Thr Arg Leu Ser Ser Thr Ala Asp Thr Pro Met Leu Ala 
465                 470                 475                 480 
Gly Val Ser Glu Tyr Glu Leu Pro Glu Asp Pro Lys Trp Glu Phe Pro 
                485                 490                 495     
Arg Asp Lys Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly 
            500                 505                 510         
Gln Val Val Met Ala Glu Ala Val Gly Ile Asp Lys Asp Lys Pro Lys 
        515                 520                 525             
Glu Ala Val Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Glu 
    530                 535                 540                 
Lys Asp Leu Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile 
545                 550                 555                 560 
Gly Lys His Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp 
                565                 570                 575     
Gly Pro Leu Tyr Val Ile Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg 
            580                 585                 590         
Glu Tyr Leu Arg Ala Arg Arg Pro Pro Gly Met Glu Tyr Ser Tyr Asp 
        595                 600                 605             
Ile Asn Arg Val Pro Glu Glu Gln Met Thr Phe Lys Asp Leu Val Ser 
    610                 615                 620                 
Cys Thr Tyr Gln Leu Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys 
625                 630                 635                 640 
Cys Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asn 
                645                 650                 655     
Asn Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile Asn Asn 
            660                 665                 670         
Ile Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp 
        675                 680                 685             
Met Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp 
    690                 695                 700                 
Val Trp Ser Phe Gly Val Leu Met Trp Glu Ile Phe Thr Leu Gly Gly 
705                 710                 715                 720 
Ser Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys 
                725                 730                 735     
Glu Gly His Arg Met Asp Lys Pro Thr Asn Cys Thr Asn Glu Leu Tyr 
            740                 745                 750         
Met Met Met Arg Asp Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr 
        755                 760                 765             
Phe Lys Gln Leu Val Glu Asp Leu Asp Arg Ile Leu Thr Leu Thr Thr 
    770                 775                 780                 
Asn Glu Glu Tyr Leu Asp Leu Thr Gln Pro Leu Glu Gln Tyr Ser Pro 
785                 790                 795                 800 
Ser Tyr Pro Asp Thr Arg Ser Ser Cys Ser Ser Gly Asp Asp Ser Val 
                805                 810                 815     
Phe Ser Pro Asp Pro Met Pro Tyr Glu Pro Cys Leu Pro Gln Tyr Pro 
            820                 825                 830         
His Ile Asn Gly Ser Val Lys Thr 
        835                 840 

<210> 47
<211> 806
<212> PRT
<213> Homo sapiens

<220> 
<223> human FGFR3

<400> 47
Met Gly Ala Pro Ala Cys Ala Leu Ala Leu Cys Val Ala Val Ala Ile 
1               5                   10                  15      
Val Ala Gly Ala Ser Ser Glu Ser Leu Gly Thr Glu Gln Arg Val Val 
            20                  25                  30          
Gly Arg Ala Ala Glu Val Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln 
        35                  40                  45              
Leu Val Phe Gly Ser Gly Asp Ala Val Glu Leu Ser Cys Pro Pro Pro 
    50                  55                  60                  
Gly Gly Gly Pro Met Gly Pro Thr Val Trp Val Lys Asp Gly Thr Gly 
65                  70                  75                  80  
Leu Val Pro Ser Glu Arg Val Leu Val Gly Pro Gln Arg Leu Gln Val 
                85                  90                  95      
Leu Asn Ala Ser His Glu Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg 
            100                 105                 110         
Leu Thr Gln Arg Val Leu Cys His Phe Ser Val Arg Val Thr Asp Ala 
        115                 120                 125             
Pro Ser Ser Gly Asp Asp Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr 
    130                 135                 140                 
Gly Val Asp Thr Gly Ala Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp 
145                 150                 155                 160 
Lys Lys Leu Leu Ala Val Pro Ala Ala Asn Thr Val Arg Phe Arg Cys 
                165                 170                 175     
Pro Ala Ala Gly Asn Pro Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly 
            180                 185                 190         
Arg Glu Phe Arg Gly Glu His Arg Ile Gly Gly Ile Lys Leu Arg His 
        195                 200                 205             
Gln Gln Trp Ser Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly 
    210                 215                 220                 
Asn Tyr Thr Cys Val Val Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr 
225                 230                 235                 240 
Tyr Thr Leu Asp Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln 
                245                 250                 255     
Ala Gly Leu Pro Ala Asn Gln Thr Ala Val Leu Gly Ser Asp Val Glu 
            260                 265                 270         
Phe His Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu 
        275                 280                 285             
Lys His Val Glu Val Asn Gly Ser Lys Val Gly Pro Asp Gly Thr Pro 
    290                 295                 300                 
Tyr Val Thr Val Leu Lys Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu 
305                 310                 315                 320 
Leu Glu Val Leu Ser Leu His Asn Val Thr Phe Glu Asp Ala Gly Glu 
                325                 330                 335     
Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Phe Ser His His Ser Ala 
            340                 345                 350         
Trp Leu Val Val Leu Pro Ala Glu Glu Glu Leu Val Glu Ala Asp Glu 
        355                 360                 365             
Ala Gly Ser Val Tyr Ala Gly Ile Leu Ser Tyr Gly Val Gly Phe Phe 
    370                 375                 380                 
Leu Phe Ile Leu Val Val Ala Ala Val Thr Leu Cys Arg Leu Arg Ser 
385                 390                 395                 400 
Pro Pro Lys Lys Gly Leu Gly Ser Pro Thr Val His Lys Ile Ser Arg 
                405                 410                 415     
Phe Pro Leu Lys Arg Gln Val Ser Leu Glu Ser Asn Ala Ser Met Ser 
            420                 425                 430         
Ser Asn Thr Pro Leu Val Arg Ile Ala Arg Leu Ser Ser Gly Glu Gly 
        435                 440                 445             
Pro Thr Leu Ala Asn Val Ser Glu Leu Glu Leu Pro Ala Asp Pro Lys 
    450                 455                 460                 
Trp Glu Leu Ser Arg Ala Arg Leu Thr Leu Gly Lys Pro Leu Gly Glu 
465                 470                 475                 480 
Gly Cys Phe Gly Gln Val Val Met Ala Glu Ala Ile Gly Ile Asp Lys 
                485                 490                 495     
Asp Arg Ala Ala Lys Pro Val Thr Val Ala Val Lys Met Leu Lys Asp 
            500                 505                 510         
Asp Ala Thr Asp Lys Asp Leu Ser Asp Leu Val Ser Glu Met Glu Met 
        515                 520                 525             
Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn Leu Leu Gly Ala 
    530                 535                 540                 
Cys Thr Gln Gly Gly Pro Leu Tyr Val Leu Val Glu Tyr Ala Ala Lys 
545                 550                 555                 560 
Gly Asn Leu Arg Glu Phe Leu Arg Ala Arg Arg Pro Pro Gly Leu Asp 
                565                 570                 575     
Tyr Ser Phe Asp Thr Cys Lys Pro Pro Glu Glu Gln Leu Thr Phe Lys 
            580                 585                 590         
Asp Leu Val Ser Cys Ala Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu 
        595                 600                 605             
Ala Ser Gln Lys Cys Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu 
    610                 615                 620                 
Val Thr Glu Asp Asn Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg 
625                 630                 635                 640 
Asp Val His Asn Leu Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu 
                645                 650                 655     
Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr 
            660                 665                 670         
His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe 
        675                 680                 685             
Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe 
    690                 695                 700                 
Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro Ala Asn Cys Thr 
705                 710                 715                 720 
His Asp Leu Tyr Met Ile Met Arg Glu Cys Trp His Ala Ala Pro Ser 
                725                 730                 735     
Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu Asp Arg Val Leu 
            740                 745                 750         
Thr Val Thr Ser Thr Asp Glu Tyr Leu Asp Leu Ser Ala Pro Phe Glu 
        755                 760                 765             
Gln Tyr Ser Pro Gly Gly Gln Asp Thr Pro Ser Ser Ser Ser Ser Gly 
    770                 775                 780                 
Asp Asp Ser Val Phe Ala His Asp Leu Leu Pro Pro Ala Pro Pro Ser 
785                 790                 795                 800 
Ser Gly Gly Ser Arg Thr 
                805     

<210> 48
<211> 782
<212> PRT
<213> Mus musculus

<220> 
<223> murine FGFR3

<400> 48
Met Val Val Pro Ala Cys Val Leu Val Phe Cys Val Ala Val Val Ala 
1               5                   10                  15      
Gly Ala Thr Ser Glu Pro Pro Gly Pro Glu Gln Arg Val Val Arg Arg 
            20                  25                  30          
Ala Ala Glu Val Pro Gly Pro Glu Pro Ser Gln Gln Glu Gln Val Ala 
        35                  40                  45              
Phe Gly Ser Gly Asp Thr Val Glu Leu Ser Cys His Pro Pro Gly Gly 
    50                  55                  60                  
Ala Pro Thr Gly Pro Thr Val Trp Ala Lys Asp Gly Thr Gly Leu Val 
65                  70                  75                  80  
Ala Ser His Arg Ile Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn 
                85                  90                  95      
Ala Ser His Glu Asp Ala Gly Val Tyr Ser Cys Gln His Arg Leu Thr 
            100                 105                 110         
Arg Arg Val Leu Cys His Phe Ser Val Arg Val Thr Gly Ala Pro Tyr 
        115                 120                 125             
Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu Leu Ala Val Pro Ala 
    130                 135                 140                 
Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala Gly Asn Pro Thr Pro 
145                 150                 155                 160 
Ser Ile Ser Trp Leu Lys Asn Gly Lys Glu Phe Arg Gly Glu His Arg 
                165                 170                 175     
Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val Met Glu 
            180                 185                 190         
Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val Glu Asn 
        195                 200                 205             
Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val Leu Glu Arg 
    210                 215                 220                 
Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Gln Thr 
225                 230                 235                 240 
Ala Ile Leu Gly Ser Asp Val Glu Phe His Cys Lys Val Tyr Ser Asp 
                245                 250                 255     
Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu Val Asn Gly Ser 
            260                 265                 270         
Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys Thr Ala 
        275                 280                 285             
Gly Ala Asn Thr Thr Asp Lys Glu Leu Glu Val Leu Ser Leu His Asn 
    290                 295                 300                 
Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser 
305                 310                 315                 320 
Ile Gly Phe Ser His His Ser Ala Trp Leu Val Val Leu Pro Ala Glu 
                325                 330                 335     
Glu Glu Leu Met Glu Thr Asp Glu Ala Gly Ser Val Tyr Ala Gly Val 
            340                 345                 350         
Leu Ser Tyr Gly Val Val Phe Phe Leu Phe Ile Leu Val Val Ala Ala 
        355                 360                 365             
Val Ile Leu Cys Arg Leu Arg Ser Pro Pro Lys Lys Gly Leu Gly Ser 
    370                 375                 380                 
Pro Thr Val His Lys Val Ser Arg Phe Pro Leu Lys Arg Gln Val Ser 
385                 390                 395                 400 
Leu Glu Ser Asn Ser Ser Met Asn Ser Asn Thr Pro Leu Val Arg Ile 
                405                 410                 415     
Ala Arg Leu Ser Ser Gly Glu Gly Pro Val Leu Ala Asn Val Ser Glu 
            420                 425                 430         
Leu Glu Leu Pro Ala Asp Pro Lys Trp Glu Leu Ser Arg Thr Arg Leu 
        435                 440                 445             
Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Met 
    450                 455                 460                 
Ala Glu Ala Ile Gly Ile Asp Lys Asp Arg Thr Ala Lys Pro Val Thr 
465                 470                 475                 480 
Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Asp Lys Asp Leu Ser 
                485                 490                 495     
Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys 
            500                 505                 510         
Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Gly Gly Pro Leu Tyr 
        515                 520                 525             
Val Leu Val Glu Tyr Ala Ala Lys Gly Asn Leu Arg Glu Phe Leu Arg 
    530                 535                 540                 
Ala Arg Arg Pro Pro Gly Met Asp Tyr Ser Phe Asp Ala Cys Arg Leu 
545                 550                 555                 560 
Pro Glu Glu Gln Leu Thr Cys Lys Asp Leu Val Ser Cys Ala Tyr Gln 
                565                 570                 575     
Val Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile His Arg 
            580                 585                 590         
Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn Val Met Lys 
        595                 600                 605             
Ile Ala Asp Phe Gly Leu Ala Arg Asp Val His Asn Leu Asp Tyr Tyr 
    610                 615                 620                 
Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu 
625                 630                 635                 640 
Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser Phe 
                645                 650                 655     
Gly Val Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro 
            660                 665                 670         
Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg 
        675                 680                 685             
Met Asp Lys Pro Ala Ser Cys Thr His Asp Leu Tyr Met Ile Met Arg 
    690                 695                 700                 
Glu Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu 
705                 710                 715                 720 
Val Glu Asp Leu Asp Arg Ile Leu Thr Val Thr Ser Thr Asp Glu Tyr 
                725                 730                 735     
Leu Asp Leu Ser Val Pro Phe Glu Gln Tyr Ser Pro Gly Gly Gln Asp 
            740                 745                 750         
Thr Pro Ser Ser Ser Ser Ser Gly Asp Asp Ser Val Phe Thr His Asp 
        755                 760                 765             
Leu Leu Pro Pro Gly Pro Pro Ser Asn Gly Gly Pro Arg Thr 
    770                 775                 780         

<210> 49
<211> 802
<212> PRT
<213> Homo sapiens

<220> 
<223> human FGFR4

<400> 49
Met Arg Leu Leu Leu Ala Leu Leu Gly Val Leu Leu Ser Val Pro Gly 
1               5                   10                  15      
Pro Pro Val Leu Ser Leu Glu Ala Ser Glu Glu Val Glu Leu Glu Pro 
            20                  25                  30          
Cys Leu Ala Pro Ser Leu Glu Gln Gln Glu Gln Glu Leu Thr Val Ala 
        35                  40                  45              
Leu Gly Gln Pro Val Arg Leu Cys Cys Gly Arg Ala Glu Arg Gly Gly 
    50                  55                  60                  
His Trp Tyr Lys Glu Gly Ser Arg Leu Ala Pro Ala Gly Arg Val Arg 
65                  70                  75                  80  
Gly Trp Arg Gly Arg Leu Glu Ile Ala Ser Phe Leu Pro Glu Asp Ala 
                85                  90                  95      
Gly Arg Tyr Leu Cys Leu Ala Arg Gly Ser Met Ile Val Leu Gln Asn 
            100                 105                 110         
Leu Thr Leu Ile Thr Gly Asp Ser Leu Thr Ser Ser Asn Asp Asp Glu 
        115                 120                 125             
Asp Pro Lys Ser His Arg Asp Pro Ser Asn Arg His Ser Tyr Pro Gln 
    130                 135                 140                 
Gln Ala Pro Tyr Trp Thr His Pro Gln Arg Met Glu Lys Lys Leu His 
145                 150                 155                 160 
Ala Val Pro Ala Gly Asn Thr Val Lys Phe Arg Cys Pro Ala Ala Gly 
                165                 170                 175     
Asn Pro Thr Pro Thr Ile Arg Trp Leu Lys Asp Gly Gln Ala Phe His 
            180                 185                 190         
Gly Glu Asn Arg Ile Gly Gly Ile Arg Leu Arg His Gln His Trp Ser 
        195                 200                 205             
Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly Thr Tyr Thr Cys 
    210                 215                 220                 
Leu Val Glu Asn Ala Val Gly Ser Ile Arg Tyr Asn Tyr Leu Leu Asp 
225                 230                 235                 240 
Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro 
                245                 250                 255     
Ala Asn Thr Thr Ala Val Val Gly Ser Asp Val Glu Leu Leu Cys Lys 
            260                 265                 270         
Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Ile Val 
        275                 280                 285             
Ile Asn Gly Ser Ser Phe Gly Ala Asp Gly Phe Pro Tyr Val Gln Val 
    290                 295                 300                 
Leu Lys Thr Ala Asp Ile Asn Ser Ser Glu Val Glu Val Leu Tyr Leu 
305                 310                 315                 320 
Arg Asn Val Ser Ala Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly 
                325                 330                 335     
Asn Ser Ile Gly Leu Ser Tyr Gln Ser Ala Trp Leu Thr Val Leu Pro 
            340                 345                 350         
Glu Glu Asp Pro Thr Trp Thr Ala Ala Ala Pro Glu Ala Arg Tyr Thr 
        355                 360                 365             
Asp Ile Ile Leu Tyr Ala Ser Gly Ser Leu Ala Leu Ala Val Leu Leu 
    370                 375                 380                 
Leu Leu Ala Gly Leu Tyr Arg Gly Gln Ala Leu His Gly Arg His Pro 
385                 390                 395                 400 
Arg Pro Pro Ala Thr Val Gln Lys Leu Ser Arg Phe Pro Leu Ala Arg 
                405                 410                 415     
Gln Phe Ser Leu Glu Ser Gly Ser Ser Gly Lys Ser Ser Ser Ser Leu 
            420                 425                 430         
Val Arg Gly Val Arg Leu Ser Ser Ser Gly Pro Ala Leu Leu Ala Gly 
        435                 440                 445             
Leu Val Ser Leu Asp Leu Pro Leu Asp Pro Leu Trp Glu Phe Pro Arg 
    450                 455                 460                 
Asp Arg Leu Val Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln 
465                 470                 475                 480 
Val Val Arg Ala Glu Ala Phe Gly Met Asp Pro Ala Arg Pro Asp Gln 
                485                 490                 495     
Ala Ser Thr Val Ala Val Lys Met Leu Lys Asp Asn Ala Ser Asp Lys 
            500                 505                 510         
Asp Leu Ala Asp Leu Val Ser Glu Met Glu Val Met Lys Leu Ile Gly 
        515                 520                 525             
Arg His Lys Asn Ile Ile Asn Leu Leu Gly Val Cys Thr Gln Glu Gly 
    530                 535                 540                 
Pro Leu Tyr Val Ile Val Glu Cys Ala Ala Lys Gly Asn Leu Arg Glu 
545                 550                 555                 560 
Phe Leu Arg Ala Arg Arg Pro Pro Gly Pro Asp Leu Ser Pro Asp Gly 
                565                 570                 575     
Pro Arg Ser Ser Glu Gly Pro Leu Ser Phe Pro Val Leu Val Ser Cys 
            580                 585                 590         
Ala Tyr Gln Val Ala Arg Gly Met Gln Tyr Leu Glu Ser Arg Lys Cys 
        595                 600                 605             
Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn 
    610                 615                 620                 
Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Gly Val His His Ile 
625                 630                 635                 640 
Asp Tyr Tyr Lys Lys Thr Ser Asn Gly Arg Leu Pro Val Lys Trp Met 
                645                 650                 655     
Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val 
            660                 665                 670         
Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser 
        675                 680                 685             
Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Ser Leu Leu Arg Glu 
    690                 695                 700                 
Gly His Arg Met Asp Arg Pro Pro His Cys Pro Pro Glu Leu Tyr Gly 
705                 710                 715                 720 
Leu Met Arg Glu Cys Trp His Ala Ala Pro Ser Gln Arg Pro Thr Phe 
                725                 730                 735     
Lys Gln Leu Val Glu Ala Leu Asp Lys Val Leu Leu Ala Val Ser Glu 
            740                 745                 750         
Glu Tyr Leu Asp Leu Arg Leu Thr Phe Gly Pro Tyr Ser Pro Ser Gly 
        755                 760                 765             
Gly Asp Ala Ser Ser Thr Cys Ser Ser Ser Asp Ser Val Phe Ser His 
    770                 775                 780                 
Asp Pro Leu Pro Leu Gly Ser Ser Ser Phe Pro Phe Gly Ser Gly Val 
785                 790                 795                 800 
Gln Thr 
        

<210> 50
<211> 799
<212> PRT
<213> Mus musculus

<220> 
<223> murine FGFR4

<400> 50
Met Trp Leu Leu Leu Ala Leu Leu Ser Ile Phe Gln Gly Thr Pro Ala 
1               5                   10                  15      
Leu Ser Leu Glu Ala Ser Glu Glu Met Glu Gln Glu Pro Cys Leu Ala 
            20                  25                  30          
Pro Ile Leu Glu Gln Gln Glu Gln Val Leu Thr Val Ala Leu Gly Gln 
        35                  40                  45              
Pro Val Arg Leu Cys Cys Gly Arg Thr Glu Arg Gly Arg His Trp Tyr 
    50                  55                  60                  
Lys Glu Gly Ser Arg Leu Ala Ser Ala Gly Arg Val Arg Gly Trp Arg 
65                  70                  75                  80  
Gly Arg Leu Glu Ile Ala Ser Phe Leu Pro Glu Asp Ala Gly Arg Tyr 
                85                  90                  95      
Leu Cys Leu Ala Arg Gly Ser Met Thr Val Val His Asn Leu Thr Leu 
            100                 105                 110         
Leu Met Asp Asp Ser Leu Thr Ser Ile Ser Asn Asp Glu Asp Pro Lys 
        115                 120                 125             
Thr Leu Ser Ser Ser Ser Ser Gly His Val Tyr Pro Gln Gln Ala Pro 
    130                 135                 140                 
Tyr Trp Thr His Pro Gln Arg Met Glu Lys Lys Leu His Ala Val Pro 
145                 150                 155                 160 
Ala Gly Asn Thr Val Lys Phe Arg Cys Pro Ala Ala Gly Asn Pro Met 
                165                 170                 175     
Pro Thr Ile His Trp Leu Lys Asp Gly Gln Ala Phe His Gly Glu Asn 
            180                 185                 190         
Arg Ile Gly Gly Ile Arg Leu Arg His Gln His Trp Ser Leu Val Met 
        195                 200                 205             
Glu Ser Val Val Pro Ser Asp Arg Gly Thr Tyr Thr Cys Leu Val Glu 
    210                 215                 220                 
Asn Ser Leu Gly Ser Ile Arg Tyr Ser Tyr Leu Leu Asp Val Leu Glu 
225                 230                 235                 240 
Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Thr 
                245                 250                 255     
Thr Ala Val Val Gly Ser Asp Val Glu Leu Leu Cys Lys Val Tyr Ser 
            260                 265                 270         
Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Val Ile Asn Gly 
        275                 280                 285             
Ser Ser Phe Gly Ala Asp Gly Phe Pro Tyr Val Gln Val Leu Lys Thr 
    290                 295                 300                 
Thr Asp Ile Asn Ser Ser Glu Val Glu Val Leu Tyr Leu Arg Asn Val 
305                 310                 315                 320 
Ser Ala Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile 
                325                 330                 335     
Gly Leu Ser Tyr Gln Ser Ala Trp Leu Thr Val Leu Pro Glu Glu Asp 
            340                 345                 350         
Leu Thr Trp Thr Thr Ala Thr Pro Glu Ala Arg Tyr Thr Asp Ile Ile 
        355                 360                 365             
Leu Tyr Val Ser Gly Ser Leu Val Leu Leu Val Leu Leu Leu Leu Ala 
    370                 375                 380                 
Gly Val Tyr His Arg Gln Val Ile Arg Gly His Tyr Ser Arg Gln Pro 
385                 390                 395                 400 
Val Thr Ile Gln Lys Leu Ser Arg Phe Pro Leu Ala Arg Gln Phe Ser 
                405                 410                 415     
Leu Glu Ser Arg Ser Ser Gly Lys Ser Ser Leu Ser Leu Val Arg Gly 
            420                 425                 430         
Val Arg Leu Ser Ser Ser Gly Pro Pro Leu Leu Thr Gly Leu Val Asn 
        435                 440                 445             
Leu Asp Leu Pro Leu Asp Pro Leu Trp Glu Phe Pro Arg Asp Arg Leu 
    450                 455                 460                 
Val Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Arg 
465                 470                 475                 480 
Ala Glu Ala Phe Gly Met Asp Pro Ser Arg Pro Asp Gln Thr Ser Thr 
                485                 490                 495     
Val Ala Val Lys Met Leu Lys Asp Asn Ala Ser Asp Lys Asp Leu Ala 
            500                 505                 510         
Asp Leu Val Ser Glu Met Glu Val Met Lys Leu Ile Gly Arg His Lys 
        515                 520                 525             
Asn Ile Ile Asn Leu Leu Gly Val Cys Thr Gln Glu Gly Pro Leu Tyr 
    530                 535                 540                 
Val Ile Val Glu Cys Ala Ala Lys Gly Asn Leu Arg Glu Phe Leu Arg 
545                 550                 555                 560 
Ala Arg Arg Pro Pro Gly Pro Asp Leu Ser Pro Asp Gly Pro Arg Ser 
                565                 570                 575     
Ser Glu Gly Pro Leu Ser Phe Pro Ala Leu Val Ser Cys Ala Tyr Gln 
            580                 585                 590         
Val Ala Arg Gly Met Gln Tyr Leu Glu Ser Arg Lys Cys Ile His Arg 
        595                 600                 605             
Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asp Val Met Lys 
    610                 615                 620                 
Ile Ala Asp Phe Gly Leu Ala Arg Gly Val His His Ile Asp Tyr Tyr 
625                 630                 635                 640 
Lys Lys Thr Ser Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu 
                645                 650                 655     
Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser Phe 
            660                 665                 670         
Gly Ile Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro 
        675                 680                 685             
Gly Ile Pro Val Glu Glu Leu Phe Ser Leu Leu Arg Glu Gly His Arg 
    690                 695                 700                 
Met Glu Arg Pro Pro Asn Cys Pro Ser Glu Leu Tyr Gly Leu Met Arg 
705                 710                 715                 720 
Glu Cys Trp His Ala Ala Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu 
                725                 730                 735     
Val Glu Ala Leu Asp Lys Val Leu Leu Ala Val Ser Glu Glu Tyr Leu 
            740                 745                 750         
Asp Leu Arg Leu Thr Phe Gly Pro Phe Ser Pro Ser Asn Gly Asp Ala 
        755                 760                 765             
Ser Ser Thr Cys Ser Ser Ser Asp Ser Val Phe Ser His Asp Pro Leu 
    770                 775                 780                 
Pro Leu Glu Pro Ser Pro Phe Pro Phe Ser Asp Ser Gln Thr Thr 
785                 790                 795                 

<210> 51
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence Actb

<400> 51
agagggaaat cgtgcgtgac                                                20


<210> 52
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence Actb

<400> 52
caatagtgat gacctggccg t                                              21


<210> 53
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence Cidea

<400> 53
tgctcttctg tatcgcccag t                                              21


<210> 54
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence Cidea

<400> 54
gccgtgttaa ggaatctgct g                                              21


<210> 55
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence Cox7a1

<400> 55
ccgacaatga cctcccagta                                                20


<210> 56
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence Cox7a1

<400> 56
tgtttgtcca agtcctccaa                                                20


<210> 57
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer Sequence Elovl3

<400> 57
tccgcgttct catgtaggtc t                                              21


<210> 58
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence Elovl3

<400> 58
ggacctgatg caaccctatg a                                              21


<210> 59
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence Foxc2

<400> 59
acgagtgcgg atttgtaacc                                                20


<210> 60
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence Foxc2

<400> 60
cagtttgggg agggacctat                                                20


<210> 61
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence Hsp90

<400> 61
aggagggtca aggaagtggt                                                20


<210> 62
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence Hsp90

<400> 62
tttttcttgt ctttgccgct                                                20


<210> 63
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence Otop1

<400> 63
ggacctgatg caaccctatg a                                              21


<210> 64
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence Otop1

<400> 64
accatgctct acgtgctgtg                                                20


<210> 65
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence Ppargc1a

<400> 65
ggacggaagc aatttttcaa                                                20


<210> 66
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence Ppargc1a

<400> 66
gagtcttggg aaaggacacg                                                20


<210> 67
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence Prb

<400> 67
taaacatctc ccagcggagt                                                20


<210> 68
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence Prb

<400> 68
acaaccatga gccaggagtc                                                20


<210> 69
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence Prdm16

<400> 69
ctgttagctt tggagccgac                                                20


<210> 70
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence Prdm16

<400> 70
gacgagggtc ctgtgatgtt                                                20


<210> 71
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence Ucp1

<400> 71
tctctgccag gacagtaccc                                                20


<210> 72
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence Ucp1

<400> 72
agaagcccaa tgatgttcag                                                20


<210> 73
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence Fgfr1

<400> 73
ccggatctac acacaccaga                                                20


<210> 74
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence Fgfr1

<400> 74
ccaccaactg cttgaacgta                                                20


<210> 75
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence Fgfr2

<400> 75
agggacacag gatggacaag                                                20


<210> 76
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence Fgfr2

<400> 76
aaacacagaa tcgtcccctg                                                20


<210> 77
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence Fgfr3

<400> 77
accgagtcta cacccaccag                                                20


<210> 78
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence Fgfr3

<400> 78
tgaggatgcg gtctaaatcc                                                20


<210> 79
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence Fgfr4

<400> 79
tggaagctct ggacaaggtc                                                20


<210> 80
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence Fgfr4

<400> 80
atacaacatt gctgctcccc                                                20


<210> 81
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence aklotho

<400> 81
ggctcaactc tcccagtcag                                                20


<210> 82
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence aklotho

<400> 82
cgcaaactag ccacaaaggt                                                20


<210> 83
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence bklotho

<400> 83
atgtccagga ggctctgaaa                                                20


<210> 84
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer sequence bklotho

<400> 84
agcaaatggt gcagtctgtg                                                20


