                         SEQUENCE LISTING

<110>  INSTITUT PASTEUR
       INSERM
 
<120>  TREATMENT OF CARDIAC DISEASES WITH MODULATORS OF THE HIPPO 
       PATHWAY

<130>  B367197 D34646

<150>  US 61/938480
<151>  2014-02-11

<160>  27    

<170>  PatentIn version 3.5

<210>  1
<211>  16109
<212>  DNA
<213>  mus musculus


<220>
<221>  misc_feature
<223>  mouse Fat4 cDNA

<400>  1
ggttcctgga aactaggacc atgaacttgg ccgcaaaccg ggctcctggc cgcaggcggc       60

tcccgctacc ttctccatct ctgtgccagc tcctgagagt ctgggggctg ctatcactgc      120

tccccggctc cgcccgagtc caagcggccg aacagcgcca ggtgttccag gtgatggaag      180

agcagccccc agggactctg gtgggcacca tcccaacgcg tcctggcttt acctatcgtc      240

tcagtgaaag ccacgccctg ttcgcgatta acagcagcac cggagcgctg tacaccaccg      300

ctaccatcga ccgcgagagc ctgcccagcg atgtggtcaa cctggtggtc ctttccagct      360

cccccacata ccctaccgag gtgcgagtgc tggtgcgtga cctcaatgac aacgccccag      420

tcttcccaga cccttcgatc gtggtcacct tcaaggagga cagtggtagc gggcgtcagg      480

tcattctgga caccgccacg gactctgaca tcggctccaa cggtgtggac caccactcct      540

accgcatcgt cagcggcaac gaggcgggcc gctttcggct ggacatcacc ttgaacccca      600

gtggcgaggg agcgttcctg cacctggtat ccaagggcgg gctggaccgc gaagtcacac      660

ctcagtacca gctcctggtg gaggtggagg acaagggtga gccaaagcgg cggggttacc      720

ttcaggtcaa cgtaactgta caggacatta acgacaatcc cccggtgttt ggcagttccc      780

attaccaggc gggggtgcct gaagacgcag ttgtgggctc cagtgtcctg caggtggcgg      840

cggcggacgc agacgagggc accaatgcag acatccgtta ccggctgcaa gatgagggaa      900

cccccttcca gatggaccca gagacggggc tcatcaccgt gagagagccg ctagatttcg      960

aggcccggcg acagtattcg ctaacagttc aggccacgga ccggggcgtg ccctctctca     1020

ccgggcgcgc cgaagcgttt atccagttgt tagatgtcaa tgacaacgac ccggtagtga     1080

agtttcgcta cttccctgcc acctcgcgct atgcttcggt ggatgagaac gcgcaggtgg     1140

gtacagtggt ggctctgctc accgtgactg acgctgactc cccagcagcc aacggaaaca     1200

tttcagtgca gattctcggg ggcaatgagc agcgccactt tgaggtgcag aggagcaagg     1260

tgcccaacct gagcctcatc aaggtggcca gcgccctgga ccgggagcgc atcccttcat     1320

acaacctcac agtctcggtc tcggataact ccggggcgcc ccctaccgcc gaggtccagg     1380

ctcgttcgtc tgtggccagc ttggtgattt ttgtcaatga catcaatgat caccctccgg     1440

tctttgagca gcaagtatac agagtgaacc tgagcgagga ggtgcctccg gggagctacg     1500

tgagtggggt gtcggccacc gatggcgact ctggtctgaa tgctaacctg cgttacagca     1560

ttgtctccgg aaatgggttg ggctggtttc acattagtga gcacagtgga ctggtgacta     1620

ccagtgctgc cgggggcctt gaccgtgaac ttgcttccca gattgtacta aatattagtg     1680

cccgagacca gggggtccac cccaaggtat cctatgccca gcttgtggta actgtcctgg     1740

atgtcaatga tgaaaagccg gtgtttagcc agcctgaagg ttatgaggtg tctgtggttg     1800

aaaatgctcc aactgggaca gagttgctgg ttctcggggc aacagacagg gatctgggtg     1860

acaatgggac agtgcgcttc tccctgcaag aggcagagaa tgaccaaagg ctcttccgcc     1920

tggatccggt atctgggagg ctgagcactg cctcctccct ggacagagag gaacaagcct     1980

tctactgtct atcgattcta gccacagacc tgggttcccc tccccagtcg tccacagctc     2040

aggtaaatgt cagtcttctg gatataaacg ataacagccc tgtgttctac ccagtccaat     2100

actttgctca tatccaggaa aatgagcctg gaggtagcta tgtcaccaca gtgtctgcta     2160

ccgacccaga catgggtccc aacggaactg ttaagtacag tatatcagct ggggacaggt     2220

ctcggtttca gattcatgcg aagagtgggg tcatttctac aaaaatggcc ctagatagag     2280

aagagaaaac agcataccag ctgcaagtag tggccacaga tgggggcaat ctacagtctc     2340

ccaaccaggc catcgtaact gtcacagtgt tagacacaca agacaaccca cctgtgttca     2400

gccaggctgc ctacagcttt gtggtctttg agaacgtggc tctggggtat catgtgggca     2460

gtgtttctgc aactacaatg gacctcaatg ccaacatcag ttatctcatc actaccgggg     2520

accagcgagg gatgtttgct atgaatcctg tcacagggca gctgaccaca gcaagtgtca     2580

ttgacaggga agaacagtcc ttttatcagc tgaaaatagt ggccagtggg ggagccgtca     2640

cgggagacac tgtggttaac atcacagtga aagatttgaa cgacaacgcc ccccacttcc     2700

tccaggcagt ggaaagcata aatgctgtgg agaactggca ggcgggacac agcatcttcc     2760

aggccaaagc cgtggacccg gatgagggtg tcaacggtag ggtgctctat agtctgaagc     2820

agaaccccaa gaacctgttt actattaatg agcagaatgg taacattagt ctgctggggg     2880

ccctagatgt ccacgctggc tcataccagg tagaaatcgt ggcctctgat atgggtgtcc     2940

ctcagctgtc ctccagtatc cttctgacag tttacgtgca tgatgtaaat gacaacccac     3000

cagtgtttga tcagatttcc tacgaggtca cactctccga gtcagagcct gtgaattctc     3060

gattcttcaa ggtacaagct tcagacaaag attctggagc aaatggggaa atagcataca     3120

cgatcacaga tgggaacaac ggggatgcct ttggcatatt cccagatggc cagctgtata     3180

taaaaagtga actggatcgt gaacttcagg acagatatgt gttactggtt gttgcctctg     3240

accgggcagt ggagcctcta agtgctactg tgaatgtcac tgtgctttta gaagatgtga     3300

atgacaacag gcctttgttt aatagcacca attacacatt ttacttcgaa gaggagcaga     3360

gagctgggtc cttcgtaggc aaagtcagtg ctgtggacaa agacttcggg ccaaatgggg     3420

aagtcaggta tgcttttgag gtgacacagc caaatttcga gttgcacgct gtcactgggg     3480

agatcaccag cactcacaag tttgataggg agtccctcat gaggagaagg gggacagcag     3540

tattcagctt cacagtgaca gccatggatc ggggcctccc tcagcccctc aaggaccagg     3600

ccactgtgca tgtctacatg aaggacatca acgacaatgc ccctaagttt ctaaaagact     3660

tttaccaagc tacagtatcc gagacggcga ccaatctgac ccaggtctta cgagtgtctg     3720

cctccgacgt ggacgaggga agcaacggtc tcattcatta ctctatcctc aaaggaaacg     3780

aagaaagaca gtttgccata gacagcttct ctggacaggt gactcttgta ggcaagctag     3840

actatgaagc aacctcagcc tactctctcc tcatccaggc agtggattca ggggccattc     3900

ccctcaactc aacctgcacc ctgagtatcg atattttgga tgagaatgat aacaccccct     3960

ctttcccaaa gtcaacacta ttcgtggatg ttttggaaaa catgaggatt ggcgaacttg     4020

tatcctccgt cactgccact gactctgact cgggtgtcaa tgctgaccta cactacacta     4080

ttacagggtc aaacaaccat gggactttta gtattagccc caacactggg agtatctttc     4140

tggccaaaaa gttggacttt gagacacagt ctttatataa attaaacata acagcgaaag     4200

accaggggcg gcctcctcga tcgtccacga tgtcagtggt gatccaggta cgggacttca     4260

atgacaaccc ccccagcttt cctccgggag acatttttaa gtcaatagtg gagaacatcc     4320

cccttggtac gtctgttatt tccgtgacag cgcatgaccc agatgcagat atcaacgggc     4380

agctgtctta cgccatcatc caacagatgc cccgaggcaa ccacttcagc atagacgaag     4440

tcaaaggaac catctacacc agtgctgaga tcgaccggga atttgccaac ctcttcgagt     4500

taacggtgaa agccaatgac caagcagtgc cgatagaaac caggaggtac gctctgaaaa     4560

atgtgaccat tttggtgacc gacctcaatg acaatgtccc aatgtttata tctcaaaatg     4620

cactggctgc agacccgtca gccatgattg gttctgtcct gactaccatc atggctgcag     4680

acccggatga aggtgccaat ggcgaggtcg agtatgagat actcaatggg gacacagaca     4740

cctttactgt ggatcgttac agtggggatc ttcgagtggc ttctgccttg gtgccttcac     4800

agctcatcta caaccttatc gtatcagcca cagacctggg cccagagcgg aggaagtcaa     4860

ccacagagct aactgtcatt ctccagggcc tagatgggcc tgttttcaca cagaccaagt     4920

acataaccat cttgaaggaa ggggaaccca ttggcaccaa tgtcatctcc atagaagcag     4980

ccagccccag agggtcagaa gctccagtgg aatattacat cgtttctgtt cgttgtgaag     5040

agaagactgt cggacgtctc tttaccattg gacggcagac gggtgtcatt caaactgcag     5100

ccattttgga ccgggagcag ggtgcgtgtc tctacctggt ggatgtttat gccatagaga     5160

agtcctctgc ctttcccagg acacagagag cagaggtaga aataacactt caagatatca     5220

atgacaaccc accggtgttt ccaacagaca ccctggatct caccgtggaa gagaacattg     5280

gagatggctc aaagattatg cagctgactg ccatggatgc tgatgagggt gccaacgctc     5340

tggtcacgta tgctctcatt agtggagctg atgacagctt ccgaattgat cctgagtctg     5400

gagacctgat agccaccaag aggttggaca gggagcacag gtccaagtac tcattgctgg     5460

ttcgtgcaga cgatggcctc cagtcctcag acatgaggat aaatatcacc atcagcgacg     5520

tgaatgacca cacccccaga ttctccaggc ccgtgtactc tttcgacatc ccagaagaca     5580

caacccctgg ttccctggtg gcagctattt tagcaacaga tgatgactct ggtgtgaatg     5640

gagagatcag ctatgtggtg gaggaggatg acggggatgg cgtgttcttt ctgaatctgg     5700

tcactggtgt cttcaacctg acccgagcac tggactatga aacacagcag tattacatcc     5760

tcacagtccg tgcggaggat ggtgggggtc agtccaccac catccgagct tacttcaaca     5820

ttcttgatgt caacgacaat ccacctgtct tcagcatgag ctcctacagc acatccttaa     5880

tggaaaacct gcctctcgga tccacggtcc ttgtgtttaa cgtcaccgat gcagatgatg     5940

gtgtcaactc tcagctgtcc tacagcattg cttcaggtga cagccttggg cagtttgcag     6000

tggataagca cggagtcctc aaaaccctca aagctttgga ccgggaaagc cagtccttct     6060

acaacctggt cattcaggtc catgacttgc cccagcctcc tacctccagg ttcaccagca     6120

cagcccaagt ttctatcatc ttgttagatg tcaatgataa cccacctatg tttctttccc     6180

ccaagttgac atacattcca gaaaacacac ccattgatac tgttgtcttc aaggctcaag     6240

cgacagaccc agacagtggc cccaacagct atattgagta tactctcctg aacccttcag     6300

gaaacaagtt cagcattggg accattgatg gtgaagtgca tcttacagga gagctggaca     6360

gagaggaagt ttccaattac agcctgacag tggtggccac agacaaaggg cagccacctc     6420

tgtcgtcctc tactgaggtt gtggttatgg tccttgacat caatgataac aaccctgttt     6480

ttgctcaggc tatgtaccga gtgcagatta aggagaacat actcactgga acagatataa     6540

tccaagtgtc tgcagcagac aatgatgaag gtaccaacgg acaggttcgc tacggcatcg     6600

tgggtggaaa cacacatcaa gagttcagga tcgactcagt gacaggggcc atcacagtgg     6660

ctaagtcttt ggatagagag acgacccctg cttacacttt aactgttcag gccacagatc     6720

ggggcagtag ccccagaacg gactcctgca cagtcgccat cactttactt gacatgaatg     6780

attttgtccc tgtatttgag ttgtctccgt attctgtgaa tgttcctgaa aatttaggga     6840

ccctgcccag agccattctt caggtggtgg caagagacga tgatcaaggt ccaaatagcc     6900

agctctcata tgttttgctt ggtggaaatg aagacaatgc ttttgtcctc acggccagtg     6960

gcgagcttcg ggtgacccag agtctggacc gggaagcaag agatcacttc gtcctggttg     7020

tcacagctgc tgatgcagga tccccagcct tgacgggaac aggaacaatc aacatcattg     7080

tagatgatat caacgacaac gtccccactt ttgccaataa catgtactta acttcaattg     7140

ccgaggatgc ccggacgggg acagatgtcc tgttggtgaa tgcctcggat gcagatgctg     7200

cggcaaatgc tgtcatcagt tacagtatca tcggtggaaa ctcgcagttc accatcaacc     7260

catccacggg acagatcatc actagtgctt tgctggacag agaaaccaaa gataattaca     7320

ctttggtcgt ggttgccagt gatgctgggt ctccagagtc tctttccagc tctactagtg     7380

tgcttgtgac catcactgat gttaatgaca acccaccccg gttccaacat cacccatacg     7440

tcacacacat cccatctcct actcctccag gttcctttgt ttttgctgtc acagtcaccg     7500

acgcggacat aggatctaat tctgaactcc attactcact ctcaggtaga aactctgaaa     7560

aatttcacat tgaccccctg aggggggcaa tcatggcagc tgggccacta agtggagctt     7620

cggaggtgac gttctctgtc catgtgaaag atggtggctc atttccaaag acagattcta     7680

ctacagtgac tgttaggttt gccaacaagg cagatttccc caaagtcaga gccaaagaac     7740

aaacattcat gtttccagaa aaccagccag tgggcactct ggtcaccact atcacagggt     7800

cctctttgag aggagaaact ttgtcttact acatcgcaag tggaaacctg ggcgacactt     7860

tccaaattga tccactaaca ggacaggtgt ccatcagcca gcctctggac tttgagaaga     7920

tacaaaaata cgttgtttgg atcgaagcta gagatggagg cttccctccc ttctcttctt     7980

atgagaagct tgacatcacg gtgctggata tcaatgacaa tgctccaaca tttgaagaag     8040

acccatttgt atctgagatc ctggaaaacc tatcccctcg gaaaatcctt accgtctcag     8100

caacggacaa ggacagtggt cccaatggac aactagacta tgagattgtg aatggcaacc     8160

aggagagcag tttcaccatc aatcatgcta caggtgaaat cagaagcatt cggccactag     8220

acagagaaaa aatatcccac tatgaactca ctgtgaaatc ttcagacaaa gggtcccctt     8280

ctcagagcac ctccgtaaaa gtgatcatca gtattttaga tgaaaacgat aacgcaccta     8340

ggttttcaca gatattcagt gcctatgttt ctgaaaactc ccccttggga tacacagtta     8400

cccgtgtaac aacttctgat gaagacattg ggataaatgc aattagtaga tattccatag     8460

tggacacaag tcttccattt actattaacc ccaacacagg agatattgtc atcagtcgac     8520

ctttaaacag agaagataca gacagataca ggatccgagt gtccgcacat gattctggct     8580

ggactgtaag taccgatgtc accatatttg tgactgacat caatgacaac actccaagat     8640

ttagcagacc ctcttattat ttagattgcc ctgaacttcc tgagcttggc tccagagtga     8700

ctcaagtgtc tgccacagat cctgatgagg ggtcaaatgg gcaggtgttt tatttcataa     8760

agtcgcagtc agagtatttc agaatcaatg ccaccactgg agagattttc aacaagcagg     8820

tgttaaaata ccaaaatgtc agtggcttca gtaatgtgaa catcaacagg cacagtttca     8880

ttgtgacagc ttctgaccga ggcaacccct ccttactcag cgagaccaca gttaccatca     8940

acacggtgga tagcaacgac aacccacctc agtttctcca aaataaatac tttaccccag     9000

ttaccaaaaa cgttaaagtt ggtactaagt taatcaaagt gactgcggtg gatgacaaag     9060

actttggatt aaactctgaa gtggagtatt tcgtgtcgga tgggaaccac ctagggaagt     9120

ttaagttaga caacgatact gggtggattt caatagcctc ttccttggtt tctgacctaa     9180

atcaaaactt cctgatcaga gtcacagcaa aggacaaagg gaacccccca ctttcctccc     9240

aagcagtcgt tcacatcaca gtcactgaag agaactacca cacccctgaa ttttcccaga     9300

accatataag tgccaccatc cctgagagcc acagcattgg gtctgtggtc agaactgtct     9360

ctgccagaga tcgtgacacc gccatgaatg gtctgatcag ttacaacatt atttcgggga     9420

atgaagaggg catctttgca atcaattcct caacaggtgt ggtaacccta gccaaagccc     9480

ttgattatga gatgagctca aagcacgaga tgaccattag tgccacagat ggaggatggg     9540

ttgcgaggac tggctactgc agcctgactg tgagtgtgat cgatgtgaat gacaattccc     9600

cagtgtttgt tcctgatgaa tttttcccaa ctgttatgga gaacgcccca agtgggacca     9660

ctgttatcca cctaaacgca acagacgctg actcgggagc caatgctgtg attgcgtaca     9720

ctgtgcagtc atcagacagt gacctgtttg ttattgaccc caacatggga gtcatcacca     9780

ctcaaggctt cttggatttt gaaaccaagc agagctacca cctcacagtg aaagccttca     9840

acgtccccga cgaggaaaag tgcagctttg ccactgtgga tatccagttg aaggggacga     9900

acgagtatgt gcctcgcttt gtttctaagc tctactactt tgaggtgtcg gaagcggctt     9960

ctagggggac tgctgttggg gaagtgtttg ccagtgacag ggacatgggt gctgatggag    10020

aagtacacta tttgattttt ggaaatagta ggaaaaaggg cttccagatc aacaagatga    10080

cagggcagat ctacgtgtct gggcttcttg atagagagaa agaagaaagg gtgtctttga    10140

aagtgttagc caagaacttt ggcaacattc gaggtgcaga tatcgatgaa gtcacagtaa    10200

atatcactgt gcttgatgct aatgacccgc cagtgtttag tctgagcacc tatagagtcc    10260

agatcagtga aggggtccct attgggaccc acgtgacctt tgtgagtgcc tttgactcag    10320

attccatccc gagctggagc aggttctcat acttcattgg gtccgggaat gaaaatggtg    10380

ccttttccat taacccacag acagggcaga tcacagttac ctcagggctg gaccgggaaa    10440

gcctgcctgt ttataatctc actgtcctgg ctgtagactc agggactccc tctgccacag    10500

gaagtgcttc cttggtagtt accctggaag acatcaatga caatggccca gtgttgactg    10560

tcagtgaagg ggaagttcta gaaaacaaac gaccaggaac tctagtgatg accctgcagt    10620

ccacagatcc tgacctccct ccaaatcaag gccccttcaa ttattacctg ctgagcacag    10680

gccccgctac taattatttc agtctcagta ccgctggcgt tctaagcaca acccgggaga    10740

tcgacagaga gcagattgcg gacttctatt tgtctgtggt caccagggat tctggggctc    10800

ctcaaatgtc atccacagga actgtgcaca tcactgttct agatcaaaat gacaacccct    10860

cacagtcccg cacagtggag atatttgtta attattacgg caacttattt cctggtggca    10920

ctctgggctc tgtgaagccc caggacccgg atgtgttaga cagtttccac tgctccctca    10980

cttcaggagt caccagcctc ttcagtatcc cagcgggcag ctgtgacctg agttcccagc    11040

ccagatccac agatggcacc tttgatctga ctgttgtcag cagcgatggg gttcacagca    11100

cagtcaccaa caatattcga gttttctttg caggattctc caatgctacg atagataaca    11160

gcatcttgct tcgtgttggt gttcccacag tcaaggactt cctgactaat cactaccttc    11220

actttctgcg cattgctagt tcccagctta cgggcctggg cacggcagtg cagctgtatg    11280

ctgcctatga ggagaacaac agaacgtttc ttttagcagc tgtgaaacga aataataacc    11340

agtatgtgaa ccccagtggt gtagccacgt tcttcgaaag catcaaagag atcctcctcc    11400

gtcagagtgg tgtcaaggtc gaatctgtgg atcacgaccc atgcattcat gggccgtgtc    11460

agaacggagg cagctgcctt cgaagacttg ccgtgggctc tgcgctgaag attcaggaga    11520

gtctgcctgt catcattgtg gccaacgagc ctctgcagcc ttcccagtgc aagtgtgtgc    11580

caggctatgc tggaagctgg tgcgaggtgg atattgatga atgcctccca gccccttgcc    11640

acaatggggg cacctgccac aacttagttg ggggattttc atgcagctgc ccagagggct    11700

tcactgggag agcctgtgag agagacatca atgaatgttt gcccagccct tgcaagcatg    11760

gggccgtctg tcaaaatttc ccagggggat tcaactgcgt gtgcaaaact ggatacacag    11820

gaaaaatgtg tgaatcttca gtcaattact gtgaatgcaa cccctgcttc aatggtggtt    11880

cctgtcagag tggtgtggag tcctattact gtcactgtcc attcggcgtc tttggcaagc    11940

actgtgagct gaacagttat ggatttgagg aactgtcata catggagttt cccagcctgg    12000

accccaacaa caactatatt tatgtcaagt ttgccaccat caaaagccat gctttattgc    12060

tttataacta tgacaaccag acgggagaga gggcagagtt cctggctctg gagattgccg    12120

aagaaagact cagattctca tacaatctgg gcagtgggac gtacaaactg accaccatga    12180

agaaggtgtc ggatggacag ttccacacag tgattgcacg gcgagcaggc atggcagctt    12240

ctttaactgt ggactcctgc tcagagaatc aagagccagg ctattgcact gtcagtaatg    12300

tggcggtttc agacgactgg actcttgatg ttcagccaaa ccgagtcact gttggaggaa    12360

tcagatcact agagccaatc cttcagagga gggggcatgt ggagagccac gattttgtgg    12420

gctgtgtaat ggagtttgct gtcaatggac gacccctgga gcccagccag gctctggcag    12480

cacaaggcat tcttgaccag tgtcctagat tggaaggcac gtgtgctcgc aacccctgcc    12540

agcatggtgg cacctgtgtg gacttctggt catggcagca gtgtcagtgc atggagggtc    12600

tgactgggaa gtactgtgaa aaatctgtca ctccagacac tgccttgtca ctagaaggca    12660

aaggacgcct ggactaccac atgagccaga gtgagaagcg ggaatacttg ctgacccaga    12720

gcatacggga caccacattg gagccttttg gggtcaatag cctggaagta aaattcagga    12780

ctcggagtga gaatggcatt ttgatccata tccaggaaag cagcaattat accacagtga    12840

agattaagaa tggcaaagtg cactttacat cggatgcagg tgttgctggg aaggtggagc    12900

gaatcatccc agaagcatac attgcagatg gccattggca taccttccgg atctcaaaga    12960

atggaagcat cactgtgctg tctgtagaca ggatacacaa cagagacatc gtccacccca    13020

ctcaggactt tggtggcatt gaggtgcttt ccatgtctct gggaggaatc ccccccaacc    13080

aagcccatcg agacactcag acaggtttta atggctgcat tgcctcagtg ctctatggtg    13140

gagagagcct ccccttcagt gggaagcaca gcttggcgtc catctccaaa acagaccctt    13200

cagtgaagat cggctgtcgg ggccctaaca tctgtgccag caacccctgc tggggcgatc    13260

ttctgtgtat caaccagtgg tatgcctaca aatgtgtccc tcctggtgac tgtgcatccc    13320

acccttgcca gaatggaggt agctgtgaac caggtctgct ctccggctac acttgcagct    13380

gtccagagtc gcacacaggg aggacctgtg agacggtggt ggcctgcctc ggtgttctct    13440

gtcctcaggg caaggtgtgc aaggctggaa gtccaggggg acacgtgtgt gtccagagtc    13500

agggtccaga tgagatatcc ttacctctgt gggcagtgcc tgcaattgtg ggcagctgtg    13560

ccacagccct agcgctgctg gtcctcagtt tgattctatg caaccagtgc aggggaaaga    13620

tgcccaaaaa ccccaaagag gagaagaagc cgaaggagaa gaagaaaaag ggcagtgaga    13680

atgtagcttt tgatgaccca gacaacatcc ctccctatgg ggatgaccta gctgttagga    13740

agcaacctga ggggaatccc aagccggaca tcatagagcg agagaacccc tatctaatct    13800

tcgatgagac tgacatcccc cacaactcag agaccatccc tagtgccccg ctggcttccc    13860

ctgagcagga gattgagcac tatgacatcg acaatgccag cagtatcgcg ccctcagatg    13920

cagacatcat ccagcactac aaacagttcc gaagccacac gcctaagttt tccatccaga    13980

ggcacagtcc tctgggcttc gccaggcagt cccctatgcc cttgggagca agcagtctga    14040

cctaccagcc ttcttcatat ggccaagggt taagaaccag ctcccttagc cactcggcct    14100

gccccactcc caaccctctg tccaggcaca gcccagctcc tttctccaaa ccatctgcct    14160

tctacaggaa cagcccagcc cgggaactgc atcttcctct gagggatggg ggtacgctgg    14220

aaatgcatgg ggacccctgc cagcctggca tgttcaacta tgccaccagg ctagggagaa    14280

gaagtaagag ccctcaggcc atggcatctc atggatcgag accagggagt cgcctcaaac    14340

agcccatagc acagatccct ctagaatctt ctcctcccgt gggactctcc atagaggagg    14400

tagagaggct caacacccct cgacccagaa accccagcat ctgcagtgca gaccatggga    14460

ggtcctcttc tgaagaagac tgtagaaggc ccctgtccag aaccaggaac ccagcagatg    14520

gcatccctgc cccagaatcg tcttctgaca gtgactccca tgattctttc acgtgctcag    14580

aaatggaata cgacagggag aagcccgtgg tctacacttc caggatgccc aagttatctc    14640

aagtcaacga atccgatgca gatgacgaag ataattatgg agccagactg aaacccagaa    14700

ggtaccatgg acgcagggct gaggggggac cagtgggtac ccctgcagca gcgtctgggg    14760

ctgcagacag caccctgaag ctggggcagc aggcaggcaa cttcaactgg gacaaccttt    14820

tgaactgggg cccaggcttt ggtcattatg tggatgtctt taaagatttg gcctctctcc    14880

cagaaaaagc agctggtaac gaagaaggta aaagtggggc agctaaacca gccgccaaag    14940

atggggaggc agaacagtat gtgtgaggtg tatgtgtggg caagaaacac tcaaagcacg    15000

gtgtggcttc ccaccagcgg gggtcacctt tgtaaaacag gccagtatag accggtggcc    15060

agggacacat ttaaagttaa ccacaaagct gctcacatag actccaaacg actgactctt    15120

taatttaaat gtgctcagtg gaacggaatg atcctcctgc atgcatcttg ttttgtgatg    15180

agttttgggg catgcaacat tgggaagtgt tgctttgtgt ttggtttgtg gttttttgcc    15240

gtttatacca ttgcagttgt agactcgagc ttgtgctttc acagtggggt tgcttgtttc    15300

cattgtagtg ttacggttgt gttttacctt gcaagatcat ttaagtttag ccaacccgtg    15360

tggagtgcag gaaggaggac ttcccacctt ggagggatga aaggctgcac atttaacact    15420

cttcagatga atagattcat atgtgatgtc gctcagacac aataagggct tgttttacat    15480

gacggtgggt actaagaata agtcattttg ttccgcactt taaagctttc ttaaaaactg    15540

tgttgacact tgtgtgtctc cgtgcgaaca gtcatggcct cctgacttac ctcaggcttc    15600

caggaagaac aagatgacca catactgtcc ccagaacact gccacctttc ctcttccggg    15660

ataacattct cagcgcactt ctaagagaca atttttaaag ttatttattg aagaaaaaaa    15720

gttctatgct tttaacattg taacaaattg acctatgcag gccctaattg gttttatttt    15780

ctatccattc aacatttacc ccaagtaccc agtttttata atttatataa agtcagattg    15840

caatgtttct tactttccgt cgttttgtag atcatttttt taatactgtg taaaactttt    15900

tttttttttt ttttacacct gagctgtggt tttgatactg atattttcct atgccggaaa    15960

cttttcttgc tttcagggaa ggtaagaaaa tgtgtttttt acatttgtta cttatgtaac    16020

attcatattt tcacagtttg atatctgtaa catactgtat gctttctacc tgtaaatgcc    16080

aacaatagaa ttaaaatatt tatttaaaa                                      16109


<210>  2
<211>  16120
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  human Fat4 cDNA

<400>  2
atggacttag caccagacag ggctactggc cgcccgtggc tcccgttgca cactctatca       60

gtatctcagc tccttcgagt gttttggcta ctgtcattgc ttccggggca ggcctgggtc      120

cacggggccg agccgcgcca ggtgttccaa gtgctggaag agcaacctcc aggcactctg      180

gtaggcacca tccagacgcg ccccggcttc acctacaggc tcagcgaaag ccacgccctg      240

tttgccataa acagtagcac cggagccctg tacaccacct ccaccatcga ccgcgagagc      300

ctgcccagcg acgtgatcaa cctggtggtc ctttccagcg cgcccaccta ccccaccgaa      360

gtgcgagtgc tggtgcggga cctcaatgac aacgcccccg ttttcccgga cccctctatc      420

gtggtcactt tcaaggaaga cagtagcagc ggacgccaag tcatcttaga caccgccacc      480

gactcggaca tcggctcaaa cggtgtggac caccgctcct accgcatcat ccgcggcaat      540

gaggcggggc gcttccgtct ggacatcacc ctgaacccga gcggcgaggg agcgttcctg      600

catctggtgt ccaagggcgg actggaccgt gaggtcactc cgcagtacca gctcctggtt      660

gaggtggagg acaagggtga gcctaagcgg cggggctacc ttcaggtaaa cgtgactgtg      720

caagacatta atgacaaccc cccggttttt ggcagttctc actaccaggc gggggtgcct      780

gaggacgcgg ttgtgggttc cagcgtcctc caggtggcgg cggcggacgc ggacgagggc      840

accaacgcgg acatccgcta tcgcctgcag gacgagggga cccccttcca aatggaccct      900

gagacgggac ttatcacggt gcgggagccc ctggacttcg aagctcggcg ccaatactcg      960

cttacggtgc aggcgatgga cagaggcgtg ccttccctca ctgggcgcgc cgaggcgctg     1020

attcagctgc tggacgtgaa tgacaatgac ccggtagtga agttccgcta cttcccggcc     1080

acctcgcgct acgcctcggt agatgagaat gctcaagtgg gcaccgtggt ggctctgctc     1140

accgtgacgg acgcagattc tcccgcggcc aacgggaaca tctccgtgca aattctcggg     1200

ggcaatgagc agcgccactt tgaagtgcaa agcagcaaag tgccgaacct gagcctaatc     1260

aaggtggcca gcgccttgga ccgcgagcgc atcccttcct acaacctcac agtttccgtc     1320

tctgataact acggggcgcc ccctggcgca gcagtccagg cgcgctcttc tgtggcaagc     1380

ctggtgattt ttgttaatga catcaatgac catcctcctg tcttttcaca gcaagtgtac     1440

agagtgaacc tgagcgagga ggcgcctccg ggaagctatg tgagtgggat atctgccact     1500

gatggcgact ctggtctcaa tgctaatctg cgttacagca ttgtctctgg caatggactg     1560

ggatggttcc atatcagtga acatagcggc ctcgtgacca ctgggtcctc tgggggcctg     1620

gaccgtgaac ttgcttccca gattgttctg aatataagtg cccgggacca gggagttcac     1680

cccaaggtgt cctatgccca gcttgtagta actctcctag atgtgaatga tgaaaagcca     1740

gtatttagcc agccagaagg gtatgatgtg tctgtggttg agaatgcccc aacagggaca     1800

gaactgttga tgctcagggc aactgacggg gacctgggtg acaacggaac agtgcgcttc     1860

tccttacaag aggcagagac tgaccggagg tccttccgtc tggatcctgt gtctgggagg     1920

ttgagtacta tttcctcctt ggacagagaa gagcaagcct tctactccct gttggttctg     1980

gccacagatc tgggctcccc tccccagtca tcaatggctc gcataaatgt gagtcttctg     2040

gatataaatg ataacagccc tgtcttctac ccggtccaat actttgctca cattaaggag     2100

aatgagcctg gaggtagcta catcaccact gtgtctgcca ctgacccaga cttgggtacc     2160

aatggtactg tcaaatatag catatctgct ggggacaggt ctcggtttca ggtcaatgct     2220

cagagtgggg ttatttctac aagaatggcc ctagacagag aagaaaaaac agcttatcag     2280

ttgcaaatag tagctactga tggtggcaat ttacaatctc ccaaccaggc aatagtaacc     2340

atcactgtat tggacactca agacaaccca cctgtattca gtcaggttgc ctacagcttt     2400

gtggtttttg agaacgtggc gctgggatat catgtgggta gtgtgtctgc atccaccatg     2460

gatctcaatt ccaacatcag ttatctcatt actactgggg atcagaaagg tatgtttgct     2520

atcaaccagg tcactgggca gcttaccaca gcaaatgtga ttgatagaga agagcaatcc     2580

ttttatcagc tgaaggtagt ggccagtggg ggcacagtga ctggagacac tatggttaac     2640

ataacagtta aggatttgaa tgacaactct ccccatttcc ttcaggcaat agagagtgta     2700

aatgtggtgg agaattggca ggcaggtcac agcattttcc aggccaaagc tgtggaccct     2760

gatgaaggtg tcaatggcat ggtactctat agtctgaagc aaaaccccaa gaacctgttt     2820

gctatcaatg aaaagaatgg cactattagt ctgcttgggc ccctggatgt tcatgctggc     2880

tcctaccaaa tagagatctt ggcatctgac atgggtgtcc cacagctctc ctctagtgtc     2940

atcttaacag tttatgtcca tgatgtaaat gacaattcac cagtgtttga ccaactctct     3000

tatgaagtca ccctttctga gtcagaacct gtgaattctc gattctttaa agtacaagct     3060

tctgataagg attcaggagc aaatggtgaa attgcataca ccattgctga aggaaataca     3120

ggggatgctt ttggcatatt cccagatggt caattgtata taaaaagtga actggaccgt     3180

gaacttcaag acagatatgt tttaatggtt gttgcttctg acagagcagt ggaacccctt     3240

agtgctactg tgaatgttac tgtaatttta gaagatgtaa atgataacag acctcttttt     3300

aacagtacca attacacatt ttacttcgaa gaagagcaga gggctgggtc gtttgtgggc     3360

aaagtaagtg ctgtagataa agactttggg ccaaatggag aagtaaggta ttcttttgaa     3420

atggtgcagc cagattttga gttgcatgcc atcagtgggg aaattacaaa tactcatcag     3480

tttgacaggg agtctcttat gaggcggaga gggactgctg tgtttagctt tacagtcata     3540

gcaacagatc aggggatccc tcagcctctc aaggatcagg ccactgtaca tgtttacatg     3600

aaggatataa atgataatgc tcccaaattt ttaaaagact tttaccaagc tacaatatca     3660

gaatcagcag ccaatctgac acaagtgtta agagtatctg cctcagatgt tgatgaaggt     3720

aataatggac ttattcacta ttctataata aaaggaaatg aagaaagaca gtttgctata     3780

gacagtacct ctggtcaggt aacactaatt ggcaaattag actatgaagc aacacctgcc     3840

tattcccttg taattcaagc agtggattca gggacaatcc ccctcaattc aacgtgtact     3900

ttaaatattg atattttaga tgaaaatgac aatacccctt ctttccctaa atcaacactc     3960

tttgttgatg ttttggaaaa catgagaatt ggtgaactcg tgtcctctgt tactgcaact     4020

gattccgatt caggtgacaa tgctgattta tattacagta ttactgggac taacaaccac     4080

ggaactttta gcattagccc aaacactggg agtatttttc ttgccaaaaa actggacttt     4140

gaaacacagt ctttgtataa attaaatata acagcaaaag accaaggaag acctcctcgt     4200

tcatctacaa tgtcagtggt tattcacgtg agggacttta atgacaatcc tcctagcttt     4260

cctcctggag atattttcaa gtctattgtt gagaacattc ccatcggtac atctgtcatt     4320

tcagtgactg cacatgaccc tgatgcagac attaatggtc aactatccta cacaatcatt     4380

caacagatgc caagaggcaa ccactttacc atagatgaag tcaaagggac tatatatact     4440

aatgctgaaa tagatcggga atttgctaat ctctttgagt tgactgtaaa agccaatgat     4500

caagctgtgc caatagaaac tagacggtat gctttgaaga acgtgaccat tttggttaca     4560

gacctcaatg acaatgtccc aatgtttata tcacaaaacg cccttgctgc agacccatca     4620

gctgtgattg gttccgttct gacaacaatt atggctgctg acccagatga aggtgctaat     4680

ggagaaatag agtatgagat catcaatggg gacacagaca ccttcattgt tgatcgttat     4740

agtggagacc tgagagtggc ttcagcgttg gtgccttcac agttgatcta caatctcata     4800

gtttcagcaa cagaccttgg gcctgaaagg aggaaatcga ccactgaatt gaccatcatt     4860

cttcagggcc ttgatggacc tgtttttact caacccaaat atataactat tttgaaggaa     4920

ggagaaccca ttggcacaaa cgtgatatca atagaagcag ctagccccag aggatctgag     4980

gccccagtgg agtattatat tgtttcagtt cgttgtgaag aaaaaactgt tggacgcctc     5040

tttactattg gacgacatac tggtataatt cagaccgcag ccattctgga ccgggagcaa     5100

ggagcatgtc tttacctggt ggatgtttat gccatagaaa aatcaactgc ttttcccaga     5160

acacagagag cagaggtaga aataacactt caggatatca atgacaatcc accagtattt     5220

ccaacggaca tgctggatct cacggtagag gagaacattg gagatggctc taagattatg     5280

cagctgacag ccatggatgc tgatgagggt gcaaatgctc tcgtcacata cactatcatt     5340

agtggagctg atgatagttt tcgcatcgac ccagaatccg gagatctgat agcaaccagg     5400

cggttggaca gggaacgccg ctccaaatat tcactgctag ttcgtgctga tgatggtctt     5460

cagtcctcgg atatgagaat taatatcact gtcagtgatg tgaatgacca tacacccaaa     5520

ttttccagac ccgtgtactc ttttgacatt cctgaggaca caatccctgg ttctttggta     5580

gcagccattt tagccacgga tgatgactct ggtgtgaatg gagaaattac atatattgtg     5640

aatgaagatg atgaagatgg catctttttc ctgaatccta ttactggggt ctttaatttg     5700

actcgattat tagattatga agtacagcaa tattatatcc tcactgttcg agcagaagat     5760

ggtgggggac aatttactac catcagagtt tatttcaata ttctagatgt aaatgataat     5820

ccacctattt tcagcttgaa ttcatacagc acatctttaa tggagaatct acctgtggga     5880

tctactgttc ttgtgtttaa tgttactgat gcagatgatg gcatcaactc tcaattgact     5940

tatagcattg cttcaggtga tagccttggg cagtttactg ttgacaagaa tggtgtactc     6000

aaagtcctaa aagctttgga tcgggaaagt cagtccttct acaacttggt tgttcaagtg     6060

catgacctgc cacagattcc agcctccaga ttcacaagca ctgctcaagt ctccattatt     6120

ttgttggatg taaatgataa cccaccgaca tttctttccc ctaaattgac atacattcca     6180

gaaaatacac ctattgatac tgttgttttc aaagctcaag caactgaccc agatagtggc     6240

ccaaacagct atattgagta cactctgctg aaccctttgg gaaacaagtt cagtattggg     6300

accattgatg gtgaagtgag gctcactgga gaactggaca gagaagaagt ttctaattat     6360

actctaacag tggtggctac agacaaaggt caaccatctc tctcttcatc tacagaggtt     6420

gtagttatgg tacttgacat caatgataac aaccccatct ttgcacaagc tttgtataaa     6480

gtggagatta atgaaaacac acttactgga acagatataa tacaagtgtt cgcagcagat     6540

ggagatgaag gcacaaatgg acaggttcgc tatggcattg ttaatggtaa taccaatcag     6600

gaatttcgga tagactctgt cacaggtgcc atcactgtcg ctaaaccttt ggatagagaa     6660

aagaccccta cctaccattt aactgttcag gcaacagatc gaggcagcac acccagaact     6720

gatacctcca cggtcagcat tgttctactg gatattaatg actttgttcc tgtatttgag     6780

ctatctccat attctgtaaa tgtccctgag aatttaggga cactacccag aacaattctt     6840

caggtggtgg caagagatga tgatcgagga tctaacagca aactctcata tgttctgttt     6900

ggtggtaatg aagacaatgc ttttactctc tcagccagtg gagaacttgg agtaacacag     6960

agtctggatc gggaaacaaa agagcgcttt gtcttaatga ttacagctac agattcagga     7020

tcccctgcct tgactggaac tggaacaatc aacgtcatag tagatgatgt caatgacaat     7080

gtccccacat ttgccagtaa agcgtatttc acaacaattc ctgaggatgc accaactgga     7140

acagatgttt tattggtaaa tgcctcagat gctgatgctt caaagaatgc agttataagt     7200

tataggatca tcggtggaaa ctctcagttc acgatcaacc catcgacagg acaaatcatc     7260

accagcgcat tgttagatag ggaaacaaaa gataattata ctttggtagt ggtctgcagt     7320

gatgcgggat ccccagagcc tctttccagt tccaccagtg tgcttgtcac tgtgactgat     7380

gtcaatgaca atccaccaag atttcagcat cacccatatg tcactcacat cccatctcct     7440

actcttccag gttcctttgt ctttgcggtt acagtcacag atgctgatat tggaccaaat     7500

tctgaactgc attattctct ttcgggtaga aattctgaaa aatttcacat tgacccactg     7560

aggggagcca ttatggccgc cggaccacta aacggagctt cagaagtgac attttctgtg     7620

catgtaaaag atggtggctc atttccaaag acagattcta caacagtgac tgttagattc     7680

gtgaataagg ccgatttccc taaagtgaga gccaaagaac aaacgttcat gtttcctgaa     7740

aaccaaccag tcagctctct tgtcaccacc atcacaggat cctctttaag aggagaacct     7800

atgtcatatt atatcgcaag tgggaatctt ggcaatactt tccagattga tcagttaaca     7860

gggcaggtgt ctattagtca acctctggat tttgaaaaga tacaaaaata tgttgtatgg     7920

atagaggcca gagacggtgg tttccctcct ttctcctctt acgagaaact tgatataaca     7980

gtattagatg tcaatgataa tgccccaatt tttaaggaag acccatttat atctgaaata     8040

ttggaaaacc tttcccctcg aaaaatactt actgtttcgg caatggacaa ggacagtgga     8100

cccaatggac agttagatta tgaaattgtt aatggcaaca tggaaaatag tttcagtatc     8160

aatcatgcta ctggtgaaat tagaagcgtt agacctttgg acagggaaaa agtatctcat     8220

tatgtcctaa ccataaaatc atcagacaaa gggtccccgt ctcagagtac ttcagtaaaa     8280

gtcatgatta acattttaga tgaaaatgat aatgccccta ggttttctca gatatttagt     8340

gcccatgttc ctgaaaattc ccccttagga tacacagtta cccgtgtcac aacttctgat     8400

gaagacattg ggatcaatgc aattagtaga tattctataa tggatgcaag tcttccattt     8460

acaattaatc ccagcacagg ggatattgtc ataagcagac ctttaaatag ggaagataca     8520

gaccgttaca gaattcgagt ttccgcacat gattctgggt ggactgtaag tacagatgtc     8580

acaatatttg tgacagacat caatgacaat gctccaagat ttagcagaac ttcctattat     8640

ttagattgcc ctgaacttac tgagattggc tccaaagtaa ctcaggtatt tgcaacagat     8700

cctgatgagg gatcaaatgg acaagtgttt tatttcataa aatcccaatc agaatatttc     8760

aggattaatg ccaccactgg agagattttc aataaacaga tcttaaaata ccaaaatgtc     8820

actggcttca gtaatgtgaa tatcaacagg catagtttta tagtgacatc ttcagatcga     8880

ggtaaacctt ccttaattag tgagacaaca gttaccatca atatagtgga cagtaatgac     8940

aatgcacctc aatttcttaa aagtaaatat ttcactccag tcaccaaaaa tgttaaggtt     9000

ggtacgaagt taatcagagt tacagcaata gatgacaaag attttggact gaattcagaa     9060

gtggagtatt tcatttctaa tgataaccat ttaggaaaat ttaagttgga caatgatacg     9120

gggtggattt cagtagcatc ctccctgatt tctgacttga accaaaactt ttttatcaca     9180

gtcactgcaa aggataaggg aaaccctcca ctttcttccc aagcaactgt tcacataact     9240

gtcactgagg aaaactacca tacacctgaa ttctctcaaa gccacatgag tgcaaccatc     9300

cctgagagcc atagcattgg gtccattgtc agaactgttt ctgcaagaga tagagatgca     9360

gcgatgaatg gcttgattaa gtacagcatt tcttcaggaa atgaagaagg catttttgca     9420

atcaattctt ctacaggtat attaacacta gccaaagctc ttgattatga gctatgccag     9480

aaacacgaaa tgacgattag tgctatagat ggaggatggg ttgcaagaac tggttactgc     9540

agtgtgaccg taaatgtgat tgatgtgaat gataattctc cagtattcct ctctgatgac     9600

tatttcccta ctgttttgga aaatgcccca agtggaacaa cagttatcca cctaaatgca     9660

acagatgctg actctggaac aaatgctgtg attgcgtata ctgtacagtc atctgacagt     9720

gacctctttg tcattgaccc taacacagga gtcataacca ctcaaggctt cttggatttt     9780

gaaaccaagc agagctacca tcttactgtg aaagccttca atgtccccga tgaggaaagg     9840

tgtagctttg ccactgttaa tatacaatta aaagggacaa atgaatatgt gccccgtttt     9900

gtttccaaac tttactattt tgaaatctca gaagcagctc ctaaaggtac tattgttgga     9960

gaagtgtttg ctagcgaccg tgatttgggc actgatgggg aggtacacta tttgattttt    10020

ggtaatagtc gaaagaaggg tttccagatc aataagaaga ctggacagat ttatgtttct    10080

ggaattcttg atcgagaaaa agaagaaagg gtgtctttga aggtattggc caagaacttt    10140

ggcagcatta gaggtgcaga tatagatgag gtcactgtaa atgtcaccgt gcttgatgca    10200

aatgacccac ccatttttac tctaaacatc tacagtgtgc agatcagtga aggggtccca    10260

ataggaactc atgtgacctt tgtcagtgcc tttgactcag actccatccc cagctggagc    10320

aggttttctt acttcatcgg atcagggaat gaaaatggtg ccttttctat taatccgcag    10380

acaggacaga tcaccgttac tgcagaatta gatcgagaaa cccttcccat ctataatctc    10440

tcagttttgg ctgttgattc agggaccccc tcagctacag gtagtgcctc tttattagtc    10500

accctggaag atataaatga taacgggccc atgctgactg tcagtgaagg agaagtcatg    10560

gaaaacaaac ggccaggcac tttggtgatg acccttcagt ccactgaccc tgatctccct    10620

ccaaatcaag gtccctttac ttattacttg ctgagcacag gtcctgccac cagttatttc    10680

agtctgagca ctgctggagt tctgagcaca accagagaga ttgacagaga gcagattgca    10740

gacttctatc tgtctgtggt taccaaggat tctggtgttc ctcaaatgtc ttccacagga    10800

actgtgcata tcacagttat agaccaaaat gacaatcctt cacagtctcg gacggtggag    10860

atatttgtta attattatgg taacttgttt cccggtggga ttttaggctc tgtgaagcca    10920

caggatccag atgtgttaga cagcttccac tgctccctta cttcaggagt taccagcctc    10980

ttcagtattc cagggggtac ttgtgatctg aattcccagc caaggtccac agatggcacg    11040

tttgatctga ctgtccttag caatgatgga gttcacagca cagtcacgag caacatccga    11100

gttttctttg ctggattttc caatgccaca gtggataaca gcatcttact tcgtctcggc    11160

gtaccaacag taaaggactt cttgaccaac cactatcttc attttttacg cattgccagc    11220

tcacagctga caggcttagg gactgctgtg caactgtaca gtgcatatga agagaacaat    11280

agaacgtttc ttttggcagc tgtgaagcga aatcataatc agtatgtgaa tcccagtggc    11340

gtagccacct tctttgaaag catcaaagag atccttctcc ggcagagtgg agtaaaggtg    11400

gaatctgtgg atcatgactc ctgtgtgcat ggcccatgtc agaatggagg gagctgtcta    11460

cgaagattgg ctgtgagctc cgtattaaaa agccgtgaga gtcttccagt catcatcgtg    11520

gcaaatgaac ctctgcagcc tttcttatgc aagtgtctgc caggatatgc gggtagctgg    11580

tgtgaaatag atatagatga atgtcttcca tcaccttgcc acagtggtgg aacctgtcac    11640

aatttagtgg gaggattttc atgcagctgc ccagatggct tcactggtag ggcgtgtgag    11700

agagatatca atgagtgcct gcagagtcct tgcaagaatg gtgccatctg ccagaatttt    11760

ccaggaagct tcaactgtgt ttgcaaaact ggatacacag ggaaaatgtg tgaatcttca    11820

gtcaattact gtgaatgcaa cccctgcttt aatggtggtt cctgccaaag tggtgtggat    11880

tcttattatt gtcattgtcc atttggtgtc tttggaaaac actgcgagtt gaacagttat    11940

ggatttgagg agttatcata catggaattt ccaagcttgg accccaataa caactatatt    12000

tatgtcaaat ttgccacgat taaaagtcat gccttattgc tttacaacta tgacaaccag    12060

acaggcgacc gggctgagtt tttggccctt gaaattgccg aagaaagact aagattctct    12120

tataatttag gcagtggtac atataagctc accaccatga agaaggtgtc agatggacat    12180

tttcacactg tgattgccag gagagcagga atggcagcct ccttaactgt ggactcctgt    12240

tctgagaacc aagagccagg atattgtact gtcagtaatg tggcagtttc agatgactgg    12300

actcttgatg ttcagccaaa tagagttaca gttggaggta tcagatctct agaaccaatc    12360

cttcagagaa gaggacacgt ggaaagccat gattttgttg ggtgtataat ggagtttgca    12420

gtcaatggaa ggcctctgga acccagccaa gctttggcag cacaaggcat cctagatcaa    12480

tgccctaggc tggaaggcgc ttgtactcgc agcccatgcc aacatggtgg cacatgtatg    12540

gattactggt catggcagca gtgtcattgc aaagagggac tcactgggaa atactgtgaa    12600

aaatctgtta ctcctgacac tgccttatca ttagaaggca aagggcgctt ggactaccac    12660

atgagtcaga atgagaagcg ggaatatttg ttaaggcaaa gcttacgagg tgccatgttg    12720

gagccttttg gtgtgaacag tctggaagta aaatttagga ccagaagcga gaatggcgtt    12780

ttaatccata tccaagaaag cagcaattac actactgtga agattaagaa tggcaaagta    12840

tattttacat ccgatgcagg aattgctggg aaagtggaga gaaatattcc tgaagtatat    12900

gttgcagacg gccactggca cacttttcta attgggaaaa atggaacagc aacagtattg    12960

tctgttgaca gaatatataa cagagatatt atccacccta ctcaggactt cggtggcctt    13020

gatgtgctta ctatatcact tggaggaatt ccacccaatc aagcacatcg agatgcccaa    13080

acagcaggtt ttgatggctg cattgcttct atgtggtatg gtggagaaag tcttcctttc    13140

agcgggaagc atagcttggc ctccatctca aaaacagatc cctcagtgaa gattggctgc    13200

cgtggcccga acatttgtgc cagcaacccc tgctggggtg atttgctgtg cattaatcag    13260

tggtatgcct acaggtgtgt ccctcctggg gactgtgcct cccacccgtg ccagaatggt    13320

ggcagctgtg agccaggcct gcactccggc ttcacctgta gctgcccaga ctcgcacacg    13380

ggaaggacct gtgagatggt ggtggcctgt cttggcgtcc tctgtcctca ggggaaggtg    13440

tgcaaagctg gaagtcctgc ggggcatgtc tgtgttctga gtcagggccc tgaagagatc    13500

tctctgcctt tgtgggctgt gcctgccatc gtgggcagct gcgcaaccgt cttggccctc    13560

ctggtcctta gcctgatcct gtgtaaccag tgcaggggga agaaggccaa aaatcccaaa    13620

gaggagaaga aaccgaagga gaagaagaaa aagggaagtg agaacgttgc ttttgatgac    13680

cctgacaata tccctcccta tggggatgac atgactgtga ggaagcagcc tgaagggaac    13740

ccaaaaccag atatcattga aagggaaaac ccctacctta tctatgatga aactgatatt    13800

cctcacaact cagaaaccat ccccagcgcc cctttggcat ctccagagca ggagatagag    13860

cactatgaca ttgacaacgc cagcagcatc gccccttcgg atgcagacat cattcaacac    13920

tacaagcagt tccgcagcca cacaccaaaa ttttcaatcc agaggcacag tcccctaggc    13980

tttgcaaggc aatcccccat gcccttagga gcaagcagtt tgacttacca gccttcatat    14040

ggtcaaggtt tgagaaccag ctccctaagc cactcagcat gcccaactcc caaccctctg    14100

tctcgacaca gtccagcccc tttctccaaa tcttctacgt tctatagaaa cagcccagca    14160

agggaattgc atcttcctat aagggatggt aatactttgg aaatgcatgg tgacacctgc    14220

caacctggca ttttcaacta tgccacaagg ctgggaagga gaagcaagag tcctcaggcc    14280

atggcatcac atggttctag accagggagt cgcctaaagc agccgattgg gcagattcca    14340

ctggaatctt ctcctccagt cggactttct attgaagaag tggagaggct caacacacct    14400

cgccctagaa acccaagtat ctgcagtgca gaccatggga ggtcttcttc agaggaggac    14460

tgcagaaggc cactgtctag aacaaggaat ccagcggatg gcattccagc tccagaatcc    14520

tcttctgata gtgactccca tgaatctttc acttgctcag aaatggaata tgacagggag    14580

aagccaatgg tatatacttc cagaatgccc aaattatctc aagtcaatga atctgatgca    14640

gatgatgaag ataattatgg agccagactg aagcctcgaa ggtaccacgg tcgcagggcc    14700

gagggaggac ctgtgggcac ccaggcagca gcaccaggca ctgctgacaa cacactgccc    14760

atgaagctag ggcagcaagc agggactttc aactgggaca accttttgaa ctggggccct    14820

ggctttggcc attatgtaga tgtttttaaa gatttggcat ctcttccaga aaaagcagca    14880

gcaaatgaag aaggcaaagc tgggacaact aaaccagtcc ccaaagatgg ggaagcagaa    14940

cagtatgtgt gaagtttatg tactggcact ataaaatata aaaacaagaa ataatactca    15000

aaccattgta aagttgctga ctaggttggg tcacatttga aaaacaggcc agtatggact    15060

agtggtggag ggaaaacttt aaaaataata accacaatgc tgctgaaaca gactcacaac    15120

aactcttaat ttaaacatgt gtggttgaat ttatttccct gcatgcattg tgttttgtaa    15180

ctagttatgt ggcatgcagc atttggaaaa tttttcttat ttaccagtgt ttgatttgtg    15240

atttttaaaa attgatacct ttaccattgc agaaaagaac ttgtgctttc ccagtggcgt    15300

atgtgtattg tttcaactgt attattataa ttatattttg cattgcaaga ttcttgatgt    15360

taaaccaatc cttgtaaagt gtaaaaagga accctcctat cgtggaatga aagattaagt    15420

atattaacac ttttcagaat gatagtttct gtatttgatg ttgctcagaa atgtctgagt    15480

atttgagtaa gttttacatg acagtgggta ctgaaattaa gtcattttgt tcagcacttt    15540

aacgctttct tatagaattg tcttaaaact tctggatcct tgagcaaatg attatagtct    15600

cctgactttc atgaggcttc cattaggaac agaatgattg catgttgtcc ccagaacact    15660

gccaccttgc tatgcgaatg atgttctcag cagcacttct aagaaacact cttaaaagtt    15720

atttattgaa aatttttcgt atgcttttaa tattttaaag aattgaccta aggaaagctt    15780

atgattggac ttattttcca accagataac atttactcta agtacccagt ttttataatt    15840

tatatgaaat cagatttcaa cacttacttt gtcattttgt agatcatttt ttttaaatac    15900

tgtgtaaaaa ctttttttac acctaagctg tgtttttgat actgatattt tcctatgctg    15960

aatagttttc ttactttcag ggaaggtaag aaaatacttt ttttatattt gttacttatg    16020

taacattcat atttttctca ttttgatatt tgtaacatac tgtatgcttt ctacttgtaa    16080

atgtcaacaa tagaattaaa atatttattt aaaataaaaa                          16120


<210>  3
<211>  16066
<212>  DNA
<213>  rattus norvegicus


<220>
<221>  misc_feature
<223>  Rat Fat4 cDNA

<400>  3
atgaacttgg ccgcaaaccg gactccgggc cgcaggcggt tcccgctacc ttccccatct       60

ctgggccagc ttctgagagt ctggggactg ctgtcgctgc tccccagtcc ggcccgagtc      120

caagcggccg aacagcgcca ggtgtttcag gtgatggagg agcaaccccc agggactctg      180

gtgggcacca tcccaacgcg tcctggcttc acctatcggc tcagtgaaag ccacgccctg      240

ttcgctatta acagcagcac tggagcgttg tacaccaccg ctaccatcga ccgcgagagc      300

ctgcccagcg atgtggtcaa cctggtggtc ctttccagct cgcccaccta ccccaccgag      360

gtgcgcgtgc tggtgcgtga cctcaacgac aatgccccag tcttcccaga cccctcgatc      420

gtggtcacct tcaaggagga tagtggcagc gggcgtcagg tcattctgga cactgccacc      480

gactctgaca tcggctccaa cggcgtggac caccgctcct accgcatcgt ccgcggcaac      540

gaggcgggcc gctttcgcct ggacatcact ttgaacccca gtggcgaggg agcattcctg      600

cacctggtgt ccaagggtgg gctggaccgc gaggtcacac ctcagtacca gctcctggta      660

gaggtggagg acaagggtga gccaaagcgg cggggttacc ttcaggtcaa cgtgactgta      720

caggacatta acgacaatcc cccggtgttt ggcagttccc attaccaggc gggggtgcct      780

gaagacgcag ttgtgggttc cagtgtcctg caggtggcgg cggcggacgc agacgagggc      840

accaatgcgg acatccgtta ccggctgcag gacgagggaa cccccttcca gatggacccg      900

gagacggggc tcatcaccgt gagagagccg ctagactttg aggcccggcg acagtattcg      960

ctgacagttc aggccacgga ccgaggcgtg ccctcgctca ccgggcgtgc cgaagcgctt     1020

atccagctgc tagatgtcaa tgacaacgac cctgtagtga agtttcgcta cttccctgcc     1080

acctcgcgct acgcttcggt ggatgagaac gcgcaggtgg gtaccgtggt ggctctgctc     1140

accgtgaccg atgctgactc cccagcagcc aacggaaaca tttcagtgca gattctcggg     1200

ggtaatgagc agcgccactt tgaggtacag aggagcaagg tgcccaacct gagcctcatc     1260

aaggtggcca gcgccctgga ccgcgagcgc atcccttcat acaatctcac agtctcggtc     1320

tcggataact ccggggcgcc ccctactgcc gaggtccagg cccgctcctc tgtggccagc     1380

ttggtgattt ttgtcaatga catcaatgat caccctccgg tctttgagca gcaagtgtac     1440

agagtgaacc tgagtgagga agtacctccg gggagctatg tgagtggggt gtctgccacc     1500

gatggtgact ctggtctgaa tgctaacctg cgttatagca ttgtctctgg aaatgggttg     1560

ggctggtttc acattagtga gcacagtggc ctggtgacta ccagcgctgc tgggggcctt     1620

gaccgtgaac ttgcttccca gattgtactg aatatcagtg cccgagatca gggagttcac     1680

cctaaggtat cctatgccca gcttgtggtc agtgtcctgg atgttaatga ccaaaagccc     1740

gtgtttagcc agcctgaagg ctatgaggtg tctgtggttg agaatgctcc aactgggaca     1800

gagctgttgg ttcttggggc aacagatggg gatctgggtg acaatgggac agtgcgcttc     1860

tccctgcaag aggctgagag tgaccaaagg ctcttccgcc tggatccagt atctgggagg     1920

ctgagtacta tctcttccct ggacagagag gaacaagcct tctactgtct attgattcta     1980

gccacagacc tgggttcccc tccccagtcc tccaccgtgc aggtaaacgt cagtctcctt     2040

gatataaacg acaacagccc tgtgttctac ccagtccaat actttgctca tatccaggaa     2100

aatgagcccg gaggtagcta tgtcaccaca gtgtctgcta ctgacccaga catgggtccc     2160

aacggaactg ttaagtacag tatatcagct ggggacaggt ctcggtttca gattcatgct     2220

aagagtggag tcatttctac aaagatggcc ctagacagag aagagaaaac agcataccag     2280

ctgcaaatag tggccaccga tgggggtaat ttacagtccc ccagccaggc catagtaaca     2340

gtcacagtgc tagatacaca ggacaaccca cccgtattca gccaggctgc ctatagcttt     2400

gtggtctttg agaatgtggc tctggggtat catgtgggca gtgtttctgc aaccaccatg     2460

gaccttaatg ccaacatcag ttacctcatc accactgggg accagagagg tatgtttgct     2520

atgaatcctg ttacagggca gctgaccaca gcaagtgtca ttgacaggga agaacagtcc     2580

ttttatcagc tgagagtggt ggccagtggg ggggcagtca caggagatgc tgtggttaac     2640

atcacagtga aagatttgaa tgacaacgcc ccccacttcc tccaggcagt ggaaagcata     2700

gatgcagtgg agaactggca ggcaggacac agcatcttcc aggccaaagc cgtggaccct     2760

gatgaaggtg tcaacggtag ggtgctctat agtctgaagc agaaccccaa gaacctgttt     2820

actattaacg agcagaatgg taacatcagt ctgctgggta ccctagatgt ccatgctggc     2880

tcgtaccagg tagaaatcgt ggcctccgat atgggggtcc cccagctctc ctccagcatc     2940

attctgacag tttatgtcca cgatgtaaat gacaacccgc cagtatttga tcagatttcc     3000

tacgaggtca ccctttctga gtcagagcct gtgaactctc gattctttaa agtacaagct     3060

ttggataaag attccggagc gaatggggag atagcatacg cgatcacaga tgggaacagt     3120

ggggaggcct ttggcatatt cccagatggt cagctgtata taaagagcga actagatcgc     3180

gaacttcagg acagatatgt gttgctggtt gttgcctctg accgggcggt agagcctcta     3240

agtgctactg tgaacgtcac tgtgatttta gaagacgtga atgacaacag gcctttgttt     3300

aatagcacca attacacatt ttacttcgaa gaggagcaga gagccgggtc attcgtaggc     3360

aaagtcagcg ctgtggacaa agactttggg ccgaatgggg aagtaaggta tgcttttgag     3420

gtggcacagc cagatttcga gctgcatgcc atcactgggg agatcaccaa cactcacaag     3480

tttgacagag agtccctcat gaggagaagg gggacagcag tgttcagctt cacagtgata     3540

gccacggatc agggcctccc tcagcctctc aaggaccagg ccactgtgca tgtctacatg     3600

aaggacatca acgataatgc ccccaagttt ctaaaagact tttatcaagc tacagtatca     3660

gagacggcaa ccaatctgac ccaggtctta cgagtgtctg cctcggacgt ggatgagggg     3720

aataatggcc tcattcatta ctctatcctc aaaggaaatg aagagagaca gttttccata     3780

gacaggttct ctggccaggt gactctcgta ggcaagttag actatgaagc aaccccagcc     3840

tattccctcc tcatccaggc ggtggattca gggaccgtcc ccctcaactc gacctgtacc     3900

ctgagtattg atattttgga tgagaatgat aacactccct ctttcccgaa gtcaacactc     3960

tttgtggatg ttttggaaaa catgaggatt ggggaacttg tatcctctgt cactgccact     4020

gactcggact caggtgtcaa tgccgatctc cactacacta ttacagggtc aaacaaccac     4080

gggactttta gtattagtcc aaacaccggg agtatctttc tggccaaaaa gttggacttt     4140

gagacacagt ctttatataa attaaacata acagcgaaag accaggggcg gcctcctcgg     4200

tcatccacaa tgtcagtggt gatccatgtg agggacttca atgacaaccc cccgagcttt     4260

cctccaggag acatttttaa gtcaatcgtg gagaacatcc cccttggtac atctgttatt     4320

tctgtgacag cacatgaccc agatgcggac atcaatgggc agctgtctta tgccatcatc     4380

caacagatgc cccgaggcaa ccacttcagc atagacgaag tcaaaggaac catctacacc     4440

agtgctgaga ttgacaggga attcgccaac ctctttgagt taacggtaaa agccaatgac     4500

caagctgtgc cgatagaaac caggaggtat gctttgaaaa atgtgaccat tttggtgacg     4560

gacctcaatg acaatgtccc aatatttata tcacaaaatg cactggctgc agacccttca     4620

gccatgattg gttctgtcct gactaccatc atggctgcag acccggatga aggtgccaat     4680

ggagaggtgg agtatgagat agtcaatggg gacacagaca ccttcactgt ggatcgttac     4740

agtggagacc ttcgagtggc ttctgcactg gttccttctc agctcattta caaccttata     4800

gtatcagcca cagaccttgg cccagagaga aggaagtcaa ccacagaact gactgtcatc     4860

cttcagggcc tagatgggcc tgttttcaca cagaccaaat acataaccat cttgaaagaa     4920

ggggagccaa ttggcaccaa tgtcatctcc atagaagcag ccagccccag agggtcagaa     4980

gctccagtgg aatattacat cgtttctgtt cgttgtgaag agaagactgt cggacgtctg     5040

tttaccattg gacgtcagac tggtgtcatt caaactgcag ccattttgga ccgggagcag     5100

ggagcatgcc tctacctggt ggatgtttat gccatagaga agtcgtctgc ttttcccagg     5160

acacagagag cagaggtaga aataacactt caggatatca atgacaaccc accagtgttt     5220

ccaacagaca ccctggatct cactgtggaa gagaacattg gagatggctc taagattatg     5280

cagctgactg ccatggatgc tgacgagggt gcaaatgctt tggtcacgta tgctctcatt     5340

agtggagctg atgacagctt ccggattgac cctgaatctg gagacctgat agccaccaag     5400

aggctggata gggagcacag gtccaagtac tcattgctgg ttcgtgcaga tgacggcctc     5460

cagtcctccg acatgaggat aaacatcacc atcagcgatg tgaatgacca cacccccaga     5520

ttctccagac ctgtgtactc tttcgacatc ccagaagaca caacccctgg ttccctggtg     5580

gcagctattt tagcaacaga tgacgactct ggtgtgaatg gagagatcag ctatgtggtg     5640

gaggaagacg atggggatgg tgtatttttc ctgaatccag ttactggtgt cttcaacttg     5700

acccgagcac tggattatga aaggcagcag tattacatac tcacagtccg cgctgaggat     5760

ggcggaggac agtttaccac catccgagct tacttcaaca tacttgacat caatgacaat     5820

ccgcctgtct tcagcctgag ctcctacagc acatcgttaa tggaaaacct gcctctggga     5880

tccaccgtcc ttgtgtttaa cgtcaccgat gcagatgacg gtgtcaactc tcagctgtcc     5940

tacagcattg cttcagggga cagccttgga cagtttgcag tggataagca tggagtcctc     6000

aaagccctca aagctttgga ccgggaaagt cagtccttct acaacctggt cattcaggtc     6060

catgacttgc cccagcctcc tgcctccaga ttcacaagca cagcccaagt ctccatcatc     6120

ttgttagatg tcaatgataa cccacccatg tttctttccc ccaagttgac gtacattcca     6180

gaaaacacac ccattgatac tgttgtcttc aaggctcaag cgacagaccc agacagtggc     6240

cccaacagct atattgagta tactctcctg aaccctgcag gaaacaagtt cagcattggg     6300

accattgatg gtgaggtgca tcttactgga gagctggaca gagaggaagt ttccaattac     6360

agcctaacag tggtggccac agacaaaggg caaccacctc tgtcgtcctc tactgaggtt     6420

gtggttatgg tccttgacat caatgacaac aacccagttt ttgcccaggc tatgtaccga     6480

gtgcagatta aggagaacac actcactgga acagatataa tccaagtgtc tgcagcagat     6540

aatgatgaag gcaccaatgg gcaggttcgc tatggcatcg tgggtggaaa cacacatcag     6600

gagttcagga tcgactcggt gacaggggcc atcacagtgg ctaagtcttt ggatagagag     6660

acaatccctg cttacatttt aactgttcag gccacggatc ggggcagtag ccccagaaca     6720

gattcctgca cggtcgccat cactttactt gacatgaatg attttgttcc tgtatttgag     6780

ctgtctccgt attctgtgaa tgttcctgaa aatttagggg ccctgcccag aaccattctc     6840

caggtggtgg caagagatga tgatcaagga ccaaatagcc agctctcata tgttttgctt     6900

ggtggaaatg aagacaatgc ctttgccctt actgccagtg gtgagcttcg ggtgacccag     6960

agtctggatc gggaagcaag agatcacttc gtcttggttg tcacagctgc agatgcagga     7020

tcaccagcct tgacaggaac agggacaatc aacatcattg tagatgatat caatgacaat     7080

gtccccactt tcgccagtaa catgtacttt actgcaattc ctgaggatgc cccgacgggg     7140

acagatgtcc tgttggtaaa tgcctcagat gcagatgctg caacaaatgc tgtcatcagt     7200

atcatcggtg gaaactcaca gttcaccatc aacccatcca cgggacagat catcactagt     7260

gcactgctgg acagagaaac caaagataat tacactttgg tcgtggttgc cagtgatgct     7320

ggatctccag agtctctttc cagctctact agtgtgctgg tgtctgttac cgatgttaat     7380

gacaacccac cccggttcca gcatcaccca tatgttacac acatcccatc tcctactcct     7440

ccaggttcct ttgtttttgc tgtcacggtc actgacgctg acattggacc caattctgaa     7500

ctccattact cactctcagg tagaaactct gaaaaatttc acattgaccc tctgaggggg     7560

gcaatcatgg cagctgggcc actaagtgga gcttctgagg tgacattctc tgtccatgtg     7620

aaagatggcg gctcatttcc aaagacagat tctaccacag tgactgttag gtttgccaac     7680

aaggcagatt tccccaaagt cagagccaaa gaacaaacat tcatgtttcc agaaaaccag     7740

ccagtgggca ctctggtcac aaccatcacg gggtcctcct tgagaggaga aactttgtcc     7800

tactacatcg cgagtgggaa cctgggcaac gctttccaaa ttgatccact aacaggacag     7860

gtgtccatca gccaaccttt ggactttgag aagatacaaa aatacattgt ttggatcgaa     7920

gccagagatg ggggcttccc tcccttctct tcttatgaga agcttgacat cacggtgcta     7980

gatatcaatg acaatgcccc ggcttttgaa gaagatcctt ttgtgtctga gatcctggaa     8040

aacctatccc ctcgaaaaat ccttactgtt tcagcaacag acaaggacag tggtcccaat     8100

ggacaactag cttatgagat tgtgaatggt aaccaggaaa gcagtttcac gattaatcac     8160

gctacaggtg aaatcagaag cattcggcca ctagacagag aaaaaatatc ttattatgag     8220

ctcactgtga aatcttcaga caaagggtct ccttctcaga gcacctctgt caaagtaatt     8280

atcagtgttt tagatgaaaa tgataatgca cctaggtttt ctcagatatt cagtgcctat     8340

gtttccgaaa actctccctt gggatataca gttacccgtg tcacaacttc tgatgaagac     8400

attggcataa atgcaattag tagatattcc atagcggaca cagctcttcc atttaccatc     8460

aaccccaaca caggggatat tgtcatcagt cgacctttaa acagagaaga tacagatcga     8520

tacaggatcc gtgtgtccgc acatgattct ggctggaccg taagtactga tgtcaccata     8580

ttcgtgactg acatcaatga caacactcca agatttagca gaccctctta ttatttagat     8640

tgccctgaac ttactgaact tggctccaga gttactcaag tatctgccac tgatcccgat     8700

gaggggtcaa acggacaagt gttttatttc ataaagtcga agtcagagta tttcagaata     8760

aatgccacca ctggagagat tttcaacaag caggtgttaa aataccaaaa tgtcagtggc     8820

ttcagtaatg tgaacatcaa caggcacagt ttcattgtga cagcttctga tcgaggcaac     8880

ccttccttac tcagtgagac cacggttact atcaacacag tagacagcaa tgacaaccca     8940

cctcagtttc tcaaaaataa atactttacc ccagttacca aaaacgttaa agtcggtact     9000

aagttaatca aagtgacagc ggtagatgac aaagactttg gattaaactc tgaagtggag     9060

tactttgtgt ctaatgggaa ccacctaggg aagtttaaat tagacaatga tactgggtgg     9120

atttcaatag cgtcttcctt ggtttctgac ctaaatcaaa acttcttcat cagagtaaca     9180

gcaaaggaca aagggaatcc cccactttcc tcccaagtag tcattcacat tacagtcact     9240

gaagagaact accacacccc tgaattctcc cagagccata taagtgccac catccctgag     9300

agccacagca ttgggtctgt ggtcagaact gtctctgcca gagatcgtga cacagccatg     9360

aacggtctga tcagctacaa catttcttca gggaatgaag agggcatctt tgctatcaat     9420

tcctcaacag gtgtggtaac cctagccaaa gcccttgatt atgagttgag ctcgaagcat     9480

gagatgacca ttagcgccac agatggagga tgggttgcga ggactggcta ttgcagccta     9540

actgtgagtg tgatcgacgt gaatgacaat tctccagtgt ttgttcctga tgaattcttc     9600

ccaactgtta tggagaatgc cccaagcggg accactgtta ttcacctaaa tgcaacagat     9660

gctgactcgg gagccaatgc tgtgattgca tacactgtgc agtcatcaga cagtgatctg     9720

tttgtcattg atcccaacac aggggtcatc accactcaag gcttcttgga ttttgaaacg     9780

aagcagagct accacctcac agtgaaagcc ttcaatgtcc ctgatgagga aaagtgcagc     9840

tttgccactg ttaacatcca gttgatggga accaatgagt atgtgcctcg ctttgtttcc     9900

aagctctact actttgaagt gtcagaagcg gctcctaggg ggactgctgt tggagaagtg     9960

tttgccagtg acagggacat gggtgctgat ggagaagtgc actatttgat ctttggaaac    10020

agcaggaaga agggcttcca gatccacaag atgacagggc agatctatgt gtctgggctt    10080

cttgatagag agaaagaaga aagggtgtcc ttaaaagtgt tggccaagaa ctttggcaac    10140

atccggggcg cagacattga tgaagtcact gtgaacatca cggtgcttga tgctaatgac    10200

ccacccgtgt ttagtctgaa cacctataga gtccagatca gtgaaggggt ccctattggg    10260

acccacgtga cctttgtgag tgcctttgac tcagattcca tccctagctg gagcaggttc    10320

tcatacttca ttgggtctgg aaatgaaaat ggtgcctttt ccattaaccc acagacagga    10380

cagatcacag ttacctcagg gctggaccgg gaaagcctgc ctgtttataa tctcactgtc    10440

ttggctgtag actcagggac tccctctgcc acaggaagtg cttccttgtt agttacccta    10500

gaagacatca atgacaatgg cccagtgttg actgtcagtg aaggagaagt tctagaaaac    10560

aaacgcccag gaactctagt gatgaccctg cagtccacgg atcctgacct tccccccaat    10620

caaggccctt tcaactatta cctgctgagc acaggccctg ctactaatta tttcagtctc    10680

aacaccgctg gagttttaag cacaacccgg gaaattgacc gagagcagat tgcagacttc    10740

tatctgtctg tggtcaccag agattctggg gctcctcaga tgtcatcgac aggaactgtg    10800

cacatcactg ttctagatca aaatgacaac ccctcgcagt cccgcacagt ggagatattt    10860

gttaattatt atggcaactt atttcctggc gggactctgg gctctgtgaa gccccaggat    10920

ccggatgtgt tagacagttt ccactgttcc ctcacatcag gagtcacaag tctcttcagt    10980

atcccagcag gcagctgtga cctgagttcc cagcccagat ccacagacgg caccttcgac    11040

ctgactgtgg ttagcagcga tggggttcac agcacagtca ccaacaatat ccgagttttc    11100

tttgcaggat tctctaatgc tacgatagat aacagcattt tgcttcgtgt cggtgttccc    11160

acagtcaagg acttcctgac taatcactac cttcactttc tgcgcattgc tagttcccag    11220

cttaccggcc tgggcactgc ggtgcagctg tatgctgctt atgaggagaa caacagaacg    11280

tttcttttag cagctgtgaa acgtaatcat aaccaatatg tgaaccccag cggtgtagcc    11340

accttcttcg aaagcatcaa agagatcctt ctccggcaga gtggagtcaa ggtcgaatct    11400

gtggatcatg acccatgcat tcatgcgccg tgtcagaacg gaggcagctg ccttcgaagg    11460

cttgctgtgg gctctgcgct gaagatccag gagagtctgc ctgtcatcat tgtggccaat    11520

gaacctctgc agcctttcca gtgtaagtgt gttccaggct atgctggaag ctggtgtgaa    11580

gttgatattg atgaatgcct tccagcccct tgccacaatg gggggacctg ccacaactta    11640

gttgggggat tttcatgcag ctgctcggag ggcttcactg ggagagcctg tgagagagac    11700

attaacgaat gtctgcccag cccttgcaag catggagccg tctgtcagaa tttcccaggg    11760

ggattcaact gtgtgtgcaa aactggatac acaggaaaaa tgtgtgaatc ttcagtcaat    11820

tactgtgaat gcaatccctg cttcaatggt ggttcctgtc agagcggtgt ggagtcatat    11880

tactgccact gtccattcgg tgtctttggc aagcactgtg aactgaacag ttatggattt    11940

gaggaactgt catacatgga gtttcctagc ctggacccca acaacaacta tatttatgtc    12000

aagtttgcta ctatcaaaag tcatgcttta ttgctttata actacgacaa ccagacagga    12060

gagcgggcag agttcctggc cttggaaatt gctgaagaaa ggctcagatt ctcatataat    12120

cttggcagtg ggacatacaa actgaccacc atgaagaagg tgtcagatgg acaattccac    12180

acagtgattg ctcggcgcgc aggaatggca gcctcgttaa ctgtggactc ctgctcggag    12240

aatcaagagc caggctattg cactgtcagt aatgtggctg tttcagatga ctggactctt    12300

gatgtacagc caaaccgagt cactgttgga ggaatcagat cactagagcc aatccttcag    12360

aggaaggggc atgtggagag ccacgatttt gtgggctgta taatggagtt cgctgtgaat    12420

ggacggcccc tggagcccag ccaggctctg gcagcacaag gcatccttga tcagtgccct    12480

agactagaag gcacctgtgc tcgaaacccc tgccagcacg gtggcacctg tgtggacttc    12540

tggtcatggc agcagtgtca gtgcatggag ggcctgactg ggaagtactg tgaaaaatct    12600

gtcactccag acactgcctt gtcactagaa ggcaaaggac gcctggacta ccacatgagc    12660

cagagcgaga agcgggaata cttgctgacg cagagcatac gggaagccac attggagcct    12720

tttggtgtca atagcctgga agtaaaattc aggactcgga gtgagaatgg cattttgatc    12780

catatccagg aaagcagcaa ttataccaca gtgaagatta agaacggcaa agtgcacttt    12840

acatcagatg caggtgttgc tgggaaagtg gagcggatca tcccggaagc atacgttgcg    12900

gatggccatt ggcatacctt ccggatctca aagaatggaa gctccactgt gctgtctgta    12960

gaccggacgc acagcagaga cgttgtccac cccacgcagg actttggtgg tatcgaggtg    13020

ctttccatgt ccctgggagg aatccctccc aaccaagccc atcgggacac gcagacgggt    13080

tttaacggct gcatcgcctc agtgctctat ggcggagaga gccttccctt cagtgggaaa    13140

cacagcttag cgtccatctc caaaaccgac ccttcagtga agattggctg tcggggtccc    13200

aacatctgtg ctagcaaccc ctgctggggc gaccttctgt gtatcaacca gtggtatgcc    13260

tacaaatgcg tccctcctgg tgactgtgca tcccaccctt gccagaatgg aggtagctgt    13320

gagccaggtc tgctctctgg ctacacgtgc agctgtccag agtcacacac tgggaggacc    13380

tgtgagacag tggtggcttg cctcggtgtt ctctgtcctc agggcaaggt ttgcaaggct    13440

ggaagtcctg ggggacacgt gtgtgtccag agtcagggtc cagatgagat ctccttacct    13500

ctgtgggctg tgcctgcaat cgtgggcagc tgtgccacag ccctagcact gctcgtcctc    13560

agcttgattc tatgcaacca gtgcaggggg aagatgccca aaaaccccaa agaggagaag    13620

aagccaaagg agaaaaagaa aaagggcagt gagaatgtgg cttttgatga cccagacaac    13680

atccctccct atggggatga cctagctgtt aggaagcaac ccgaggggaa tcccaagccg    13740

gacatcatag agcgagagaa cccttaccta atcttcgatg agactgacat cccccacaac    13800

tcagagacca tccccagtgc cccactggct tcccctgagc aggaaattga acactacgac    13860

atcgacaatg ccagcagtat cgcgccctct gatgcagaca tcatccagca ctacaaacag    13920

ttccgaagcc acacgcctaa gttttctatc cagaggcaca gtcctctggg cttcgccagg    13980

cagtccccta tgcctttggg agcaagcagt ttgacctacc agccttcttc atatggtcag    14040

gcattaagaa ccagctccct cagccactcg gcctgcccca ctcccaaccc cttgtccaga    14100

cacagcccgg ctcctttctc caaaccatct gctttctaca ggaacagccc agcccgggaa    14160

ctgcatcttc ctctgcggga tggggggacg ctggaaatgc atggggaccc ctgtcagcct    14220

ggcatgttca actatgccac caggctaggt agaagaagta agagccccca ggccatggca    14280

tcacatggct cgagacctgg gagtcgcctc aagcagccca tagcacagat ccccctagaa    14340

tcttctcctc ctgtgggact gtccattgag gaggtagaga ggctcaatac ccctcgcccc    14400

agaaacccca gcatctgcag tgcagaccat gggagatcct cttctgaaga agactgtaga    14460

aggcctctgt ccagaaccag gaacccagca gatggcatcc ctgccccaga atcttcttct    14520

gacagtgact cccatgattc cttcacatgc tcagaaatgg agtacgacag ggagaagccg    14580

gtggtctaca cttccagaat gcccaagtta tctcaagtta atgaatccga tgcagatgac    14640

gaagataatt atggagccag actgaaaccc agaaggtacc atggacgcag agctgagggg    14700

ggaccggtgg gtacccctgc agcagcatct ggggctgcag acagcaccct gaaactggga    14760

cagcaggcag gcaacttcaa ctgggacaat cttttgaact ggggcccggg ctttggccac    14820

tatgtggatg tctttaaaga tttggcctct ctcccagaaa aagcagctgg taatgaagaa    14880

ggtaaaagcg gggcagctaa accagccgcc aaagacgggg aagcagaaca gtacgtgtga    14940

ggtgtatgtg tgggcaagaa acattcaaaa agatggtgtg gcttcccacc agcggggtca    15000

cctttgtaaa acaggccagt atagaccggt ggccagggag ggacacgttt aaaattaacc    15060

acaaagctgc tcacatagac tccaagtgac tctttaattt aaatgtgctc ggtggaacag    15120

aatgagcctc ctgcatgcat cttgttttgt gatgagtttt ggggcatgca acattgggga    15180

gttttgcttt gtgtttggtt tgtggttttt tgcagtttat accattgcag ttgtagacat    15240

gagcttgtct tttcacagtg gggttgcttg tttccgttgt gttttacctt gcaagatcat    15300

ttgagtttaa ccaacctgcg taaagtgcag gaaggagcgc ttcccatctt ggagggatga    15360

aagactgcac attaaccctc ttcagacgta tagattcata cgtgatgttg ctcagacacg    15420

ataagggctt gttttacatg acggtgggta ctaggcttaa gtcattttgt tccgcacttt    15480

aaagctttct taaaaactgt gtagacacac ctgtgtctct gtgcgaactg tcatggcctc    15540

ctgacttacc tcaggcttcc aggaagaaca agatgaccac atactgtccc cagaacactg    15600

ccacctttct cttctggaat aacgttctca gcgcacttct aagagacaat ttttaaagtt    15660

atttattgaa aaaaaaagtt ctatgctttt aacattgtaa caaattgacc tatgcaggcc    15720

ctaattggtt ttattttcta gccattcaac atttacccca agtacccagt tttcataatt    15780

tatataaaat cagattgcag cgtttcttac tttctgttgt tttgtagatc attttttaat    15840

actgtgtaaa actttttttt ttttacacct gagctgtggt tttgatactg atattttcct    15900

atgccggaaa cttttcttgc tttcagagaa ggtaagaaaa tgtgtttttt acatttgtta    15960

cttatgtaac attcatattt tcacagtttg atatctgtaa catactgtat gctttctacc    16020

tgtaaatgcc aacaatagaa ttaaaatatt tatttaaaat accgtg                   16066


<210>  4
<211>  4981
<212>  PRT
<213>  mus musculus


<220>
<221>  MISC_FEATURE
<223>  mouse Fat4 protein

<400>  4

Met Asn Leu Ala Ala Asn Arg Ala Pro Gly Arg Arg Arg Leu Pro Leu 
1               5                   10                  15      


Pro Ser Pro Ser Leu Cys Gln Leu Leu Arg Val Trp Gly Leu Leu Ser 
            20                  25                  30          


Leu Leu Pro Gly Ser Ala Arg Val Gln Ala Ala Glu Gln Arg Gln Val 
        35                  40                  45              


Phe Gln Val Met Glu Glu Gln Pro Pro Gly Thr Leu Val Gly Thr Ile 
    50                  55                  60                  


Pro Thr Arg Pro Gly Phe Thr Tyr Arg Leu Ser Glu Ser His Ala Leu 
65                  70                  75                  80  


Phe Ala Ile Asn Ser Ser Thr Gly Ala Leu Tyr Thr Thr Ala Thr Ile 
                85                  90                  95      


Asp Arg Glu Ser Leu Pro Ser Asp Val Val Asn Leu Val Val Leu Ser 
            100                 105                 110         


Ser Ser Pro Thr Tyr Pro Thr Glu Val Arg Val Leu Val Arg Asp Leu 
        115                 120                 125             


Asn Asp Asn Ala Pro Val Phe Pro Asp Pro Ser Ile Val Val Thr Phe 
    130                 135                 140                 


Lys Glu Asp Ser Gly Ser Gly Arg Gln Val Ile Leu Asp Thr Ala Thr 
145                 150                 155                 160 


Asp Ser Asp Ile Gly Ser Asn Gly Val Asp His His Ser Tyr Arg Ile 
                165                 170                 175     


Val Ser Gly Asn Glu Ala Gly Arg Phe Arg Leu Asp Ile Thr Leu Asn 
            180                 185                 190         


Pro Ser Gly Glu Gly Ala Phe Leu His Leu Val Ser Lys Gly Gly Leu 
        195                 200                 205             


Asp Arg Glu Val Thr Pro Gln Tyr Gln Leu Leu Val Glu Val Glu Asp 
    210                 215                 220                 


Lys Gly Glu Pro Lys Arg Arg Gly Tyr Leu Gln Val Asn Val Thr Val 
225                 230                 235                 240 


Gln Asp Ile Asn Asp Asn Pro Pro Val Phe Gly Ser Ser His Tyr Gln 
                245                 250                 255     


Ala Gly Val Pro Glu Asp Ala Val Val Gly Ser Ser Val Leu Gln Val 
            260                 265                 270         


Ala Ala Ala Asp Ala Asp Glu Gly Thr Asn Ala Asp Ile Arg Tyr Arg 
        275                 280                 285             


Leu Gln Asp Glu Gly Thr Pro Phe Gln Met Asp Pro Glu Thr Gly Leu 
    290                 295                 300                 


Ile Thr Val Arg Glu Pro Leu Asp Phe Glu Ala Arg Arg Gln Tyr Ser 
305                 310                 315                 320 


Leu Thr Val Gln Ala Thr Asp Arg Gly Val Pro Ser Leu Thr Gly Arg 
                325                 330                 335     


Ala Glu Ala Phe Ile Gln Leu Leu Asp Val Asn Asp Asn Asp Pro Val 
            340                 345                 350         


Val Lys Phe Arg Tyr Phe Pro Ala Thr Ser Arg Tyr Ala Ser Val Asp 
        355                 360                 365             


Glu Asn Ala Gln Val Gly Thr Val Val Ala Leu Leu Thr Val Thr Asp 
    370                 375                 380                 


Ala Asp Ser Pro Ala Ala Asn Gly Asn Ile Ser Val Gln Ile Leu Gly 
385                 390                 395                 400 


Gly Asn Glu Gln Arg His Phe Glu Val Gln Arg Ser Lys Val Pro Asn 
                405                 410                 415     


Leu Ser Leu Ile Lys Val Ala Ser Ala Leu Asp Arg Glu Arg Ile Pro 
            420                 425                 430         


Ser Tyr Asn Leu Thr Val Ser Val Ser Asp Asn Ser Gly Ala Pro Pro 
        435                 440                 445             


Thr Ala Glu Val Gln Ala Arg Ser Ser Val Ala Ser Leu Val Ile Phe 
    450                 455                 460                 


Val Asn Asp Ile Asn Asp His Pro Pro Val Phe Glu Gln Gln Val Tyr 
465                 470                 475                 480 


Arg Val Asn Leu Ser Glu Glu Val Pro Pro Gly Ser Tyr Val Ser Gly 
                485                 490                 495     


Val Ser Ala Thr Asp Gly Asp Ser Gly Leu Asn Ala Asn Leu Arg Tyr 
            500                 505                 510         


Ser Ile Val Ser Gly Asn Gly Leu Gly Trp Phe His Ile Ser Glu His 
        515                 520                 525             


Ser Gly Leu Val Thr Thr Ser Ala Ala Gly Gly Leu Asp Arg Glu Leu 
    530                 535                 540                 


Ala Ser Gln Ile Val Leu Asn Ile Ser Ala Arg Asp Gln Gly Val His 
545                 550                 555                 560 


Pro Lys Val Ser Tyr Ala Gln Leu Val Val Thr Val Leu Asp Val Asn 
                565                 570                 575     


Asp Glu Lys Pro Val Phe Ser Gln Pro Glu Gly Tyr Glu Val Ser Val 
            580                 585                 590         


Val Glu Asn Ala Pro Thr Gly Thr Glu Leu Leu Val Leu Gly Ala Thr 
        595                 600                 605             


Asp Arg Asp Leu Gly Asp Asn Gly Thr Val Arg Phe Ser Leu Gln Glu 
    610                 615                 620                 


Ala Glu Asn Asp Gln Arg Leu Phe Arg Leu Asp Pro Val Ser Gly Arg 
625                 630                 635                 640 


Leu Ser Thr Ala Ser Ser Leu Asp Arg Glu Glu Gln Ala Phe Tyr Cys 
                645                 650                 655     


Leu Ser Ile Leu Ala Thr Asp Leu Gly Ser Pro Pro Gln Ser Ser Thr 
            660                 665                 670         


Ala Gln Val Asn Val Ser Leu Leu Asp Ile Asn Asp Asn Ser Pro Val 
        675                 680                 685             


Phe Tyr Pro Val Gln Tyr Phe Ala His Ile Gln Glu Asn Glu Pro Gly 
    690                 695                 700                 


Gly Ser Tyr Val Thr Thr Val Ser Ala Thr Asp Pro Asp Met Gly Pro 
705                 710                 715                 720 


Asn Gly Thr Val Lys Tyr Ser Ile Ser Ala Gly Asp Arg Ser Arg Phe 
                725                 730                 735     


Gln Ile His Ala Lys Ser Gly Val Ile Ser Thr Lys Met Ala Leu Asp 
            740                 745                 750         


Arg Glu Glu Lys Thr Ala Tyr Gln Leu Gln Val Val Ala Thr Asp Gly 
        755                 760                 765             


Gly Asn Leu Gln Ser Pro Asn Gln Ala Ile Val Thr Val Thr Val Leu 
    770                 775                 780                 


Asp Thr Gln Asp Asn Pro Pro Val Phe Ser Gln Ala Ala Tyr Ser Phe 
785                 790                 795                 800 


Val Val Phe Glu Asn Val Ala Leu Gly Tyr His Val Gly Ser Val Ser 
                805                 810                 815     


Ala Thr Thr Met Asp Leu Asn Ala Asn Ile Ser Tyr Leu Ile Thr Thr 
            820                 825                 830         


Gly Asp Gln Arg Gly Met Phe Ala Met Asn Pro Val Thr Gly Gln Leu 
        835                 840                 845             


Thr Thr Ala Ser Val Ile Asp Arg Glu Glu Gln Ser Phe Tyr Gln Leu 
    850                 855                 860                 


Lys Ile Val Ala Ser Gly Gly Ala Val Thr Gly Asp Thr Val Val Asn 
865                 870                 875                 880 


Ile Thr Val Lys Asp Leu Asn Asp Asn Ala Pro His Phe Leu Gln Ala 
                885                 890                 895     


Val Glu Ser Ile Asn Ala Val Glu Asn Trp Gln Ala Gly His Ser Ile 
            900                 905                 910         


Phe Gln Ala Lys Ala Val Asp Pro Asp Glu Gly Val Asn Gly Arg Val 
        915                 920                 925             


Leu Tyr Ser Leu Lys Gln Asn Pro Lys Asn Leu Phe Thr Ile Asn Glu 
    930                 935                 940                 


Gln Asn Gly Asn Ile Ser Leu Leu Gly Ala Leu Asp Val His Ala Gly 
945                 950                 955                 960 


Ser Tyr Gln Val Glu Ile Val Ala Ser Asp Met Gly Val Pro Gln Leu 
                965                 970                 975     


Ser Ser Ser Ile Leu Leu Thr Val Tyr Val His Asp Val Asn Asp Asn 
            980                 985                 990         


Pro Pro Val Phe Asp Gln Ile Ser  Tyr Glu Val Thr Leu  Ser Glu Ser 
        995                 1000                 1005             


Glu Pro  Val Asn Ser Arg Phe  Phe Lys Val Gln Ala  Ser Asp Lys 
    1010                 1015                 1020             


Asp Ser  Gly Ala Asn Gly Glu  Ile Ala Tyr Thr Ile  Thr Asp Gly 
    1025                 1030                 1035             


Asn Asn  Gly Asp Ala Phe Gly  Ile Phe Pro Asp Gly  Gln Leu Tyr 
    1040                 1045                 1050             


Ile Lys  Ser Glu Leu Asp Arg  Glu Leu Gln Asp Arg  Tyr Val Leu 
    1055                 1060                 1065             


Leu Val  Val Ala Ser Asp Arg  Ala Val Glu Pro Leu  Ser Ala Thr 
    1070                 1075                 1080             


Val Asn  Val Thr Val Leu Leu  Glu Asp Val Asn Asp  Asn Arg Pro 
    1085                 1090                 1095             


Leu Phe  Asn Ser Thr Asn Tyr  Thr Phe Tyr Phe Glu  Glu Glu Gln 
    1100                 1105                 1110             


Arg Ala  Gly Ser Phe Val Gly  Lys Val Ser Ala Val  Asp Lys Asp 
    1115                 1120                 1125             


Phe Gly  Pro Asn Gly Glu Val  Arg Tyr Ala Phe Glu  Val Thr Gln 
    1130                 1135                 1140             


Pro Asn  Phe Glu Leu His Ala  Val Thr Gly Glu Ile  Thr Ser Thr 
    1145                 1150                 1155             


His Lys  Phe Asp Arg Glu Ser  Leu Met Arg Arg Arg  Gly Thr Ala 
    1160                 1165                 1170             


Val Phe  Ser Phe Thr Val Thr  Ala Met Asp Arg Gly  Leu Pro Gln 
    1175                 1180                 1185             


Pro Leu  Lys Asp Gln Ala Thr  Val His Val Tyr Met  Lys Asp Ile 
    1190                 1195                 1200             


Asn Asp  Asn Ala Pro Lys Phe  Leu Lys Asp Phe Tyr  Gln Ala Thr 
    1205                 1210                 1215             


Val Ser  Glu Thr Ala Thr Asn  Leu Thr Gln Val Leu  Arg Val Ser 
    1220                 1225                 1230             


Ala Ser  Asp Val Asp Glu Gly  Ser Asn Gly Leu Ile  His Tyr Ser 
    1235                 1240                 1245             


Ile Leu  Lys Gly Asn Glu Glu  Arg Gln Phe Ala Ile  Asp Ser Phe 
    1250                 1255                 1260             


Ser Gly  Gln Val Thr Leu Val  Gly Lys Leu Asp Tyr  Glu Ala Thr 
    1265                 1270                 1275             


Ser Ala  Tyr Ser Leu Leu Ile  Gln Ala Val Asp Ser  Gly Ala Ile 
    1280                 1285                 1290             


Pro Leu  Asn Ser Thr Cys Thr  Leu Ser Ile Asp Ile  Leu Asp Glu 
    1295                 1300                 1305             


Asn Asp  Asn Thr Pro Ser Phe  Pro Lys Ser Thr Leu  Phe Val Asp 
    1310                 1315                 1320             


Val Leu  Glu Asn Met Arg Ile  Gly Glu Leu Val Ser  Ser Val Thr 
    1325                 1330                 1335             


Ala Thr  Asp Ser Asp Ser Gly  Val Asn Ala Asp Leu  His Tyr Thr 
    1340                 1345                 1350             


Ile Thr  Gly Ser Asn Asn His  Gly Thr Phe Ser Ile  Ser Pro Asn 
    1355                 1360                 1365             


Thr Gly  Ser Ile Phe Leu Ala  Lys Lys Leu Asp Phe  Glu Thr Gln 
    1370                 1375                 1380             


Ser Leu  Tyr Lys Leu Asn Ile  Thr Ala Lys Asp Gln  Gly Arg Pro 
    1385                 1390                 1395             


Pro Arg  Ser Ser Thr Met Ser  Val Val Ile Gln Val  Arg Asp Phe 
    1400                 1405                 1410             


Asn Asp  Asn Pro Pro Ser Phe  Pro Pro Gly Asp Ile  Phe Lys Ser 
    1415                 1420                 1425             


Ile Val  Glu Asn Ile Pro Leu  Gly Thr Ser Val Ile  Ser Val Thr 
    1430                 1435                 1440             


Ala His  Asp Pro Asp Ala Asp  Ile Asn Gly Gln Leu  Ser Tyr Ala 
    1445                 1450                 1455             


Ile Ile  Gln Gln Met Pro Arg  Gly Asn His Phe Ser  Ile Asp Glu 
    1460                 1465                 1470             


Val Lys  Gly Thr Ile Tyr Thr  Ser Ala Glu Ile Asp  Arg Glu Phe 
    1475                 1480                 1485             


Ala Asn  Leu Phe Glu Leu Thr  Val Lys Ala Asn Asp  Gln Ala Val 
    1490                 1495                 1500             


Pro Ile  Glu Thr Arg Arg Tyr  Ala Leu Lys Asn Val  Thr Ile Leu 
    1505                 1510                 1515             


Val Thr  Asp Leu Asn Asp Asn  Val Pro Met Phe Ile  Ser Gln Asn 
    1520                 1525                 1530             


Ala Leu  Ala Ala Asp Pro Ser  Ala Met Ile Gly Ser  Val Leu Thr 
    1535                 1540                 1545             


Thr Ile  Met Ala Ala Asp Pro  Asp Glu Gly Ala Asn  Gly Glu Val 
    1550                 1555                 1560             


Glu Tyr  Glu Ile Leu Asn Gly  Asp Thr Asp Thr Phe  Thr Val Asp 
    1565                 1570                 1575             


Arg Tyr  Ser Gly Asp Leu Arg  Val Ala Ser Ala Leu  Val Pro Ser 
    1580                 1585                 1590             


Gln Leu  Ile Tyr Asn Leu Ile  Val Ser Ala Thr Asp  Leu Gly Pro 
    1595                 1600                 1605             


Glu Arg  Arg Lys Ser Thr Thr  Glu Leu Thr Val Ile  Leu Gln Gly 
    1610                 1615                 1620             


Leu Asp  Gly Pro Val Phe Thr  Gln Thr Lys Tyr Ile  Thr Ile Leu 
    1625                 1630                 1635             


Lys Glu  Gly Glu Pro Ile Gly  Thr Asn Val Ile Ser  Ile Glu Ala 
    1640                 1645                 1650             


Ala Ser  Pro Arg Gly Ser Glu  Ala Pro Val Glu Tyr  Tyr Ile Val 
    1655                 1660                 1665             


Ser Val  Arg Cys Glu Glu Lys  Thr Val Gly Arg Leu  Phe Thr Ile 
    1670                 1675                 1680             


Gly Arg  Gln Thr Gly Val Ile  Gln Thr Ala Ala Ile  Leu Asp Arg 
    1685                 1690                 1695             


Glu Gln  Gly Ala Cys Leu Tyr  Leu Val Asp Val Tyr  Ala Ile Glu 
    1700                 1705                 1710             


Lys Ser  Ser Ala Phe Pro Arg  Thr Gln Arg Ala Glu  Val Glu Ile 
    1715                 1720                 1725             


Thr Leu  Gln Asp Ile Asn Asp  Asn Pro Pro Val Phe  Pro Thr Asp 
    1730                 1735                 1740             


Thr Leu  Asp Leu Thr Val Glu  Glu Asn Ile Gly Asp  Gly Ser Lys 
    1745                 1750                 1755             


Ile Met  Gln Leu Thr Ala Met  Asp Ala Asp Glu Gly  Ala Asn Ala 
    1760                 1765                 1770             


Leu Val  Thr Tyr Ala Leu Ile  Ser Gly Ala Asp Asp  Ser Phe Arg 
    1775                 1780                 1785             


Ile Asp  Pro Glu Ser Gly Asp  Leu Ile Ala Thr Lys  Arg Leu Asp 
    1790                 1795                 1800             


Arg Glu  His Arg Ser Lys Tyr  Ser Leu Leu Val Arg  Ala Asp Asp 
    1805                 1810                 1815             


Gly Leu  Gln Ser Ser Asp Met  Arg Ile Asn Ile Thr  Ile Ser Asp 
    1820                 1825                 1830             


Val Asn  Asp His Thr Pro Arg  Phe Ser Arg Pro Val  Tyr Ser Phe 
    1835                 1840                 1845             


Asp Ile  Pro Glu Asp Thr Thr  Pro Gly Ser Leu Val  Ala Ala Ile 
    1850                 1855                 1860             


Leu Ala  Thr Asp Asp Asp Ser  Gly Val Asn Gly Glu  Ile Ser Tyr 
    1865                 1870                 1875             


Val Val  Glu Glu Asp Asp Gly  Asp Gly Val Phe Phe  Leu Asn Leu 
    1880                 1885                 1890             


Val Thr  Gly Val Phe Asn Leu  Thr Arg Ala Leu Asp  Tyr Glu Thr 
    1895                 1900                 1905             


Gln Gln  Tyr Tyr Ile Leu Thr  Val Arg Ala Glu Asp  Gly Gly Gly 
    1910                 1915                 1920             


Gln Ser  Thr Thr Ile Arg Ala  Tyr Phe Asn Ile Leu  Asp Val Asn 
    1925                 1930                 1935             


Asp Asn  Pro Pro Val Phe Ser  Met Ser Ser Tyr Ser  Thr Ser Leu 
    1940                 1945                 1950             


Met Glu  Asn Leu Pro Leu Gly  Ser Thr Val Leu Val  Phe Asn Val 
    1955                 1960                 1965             


Thr Asp  Ala Asp Asp Gly Val  Asn Ser Gln Leu Ser  Tyr Ser Ile 
    1970                 1975                 1980             


Ala Ser  Gly Asp Ser Leu Gly  Gln Phe Ala Val Asp  Lys His Gly 
    1985                 1990                 1995             


Val Leu  Lys Thr Leu Lys Ala  Leu Asp Arg Glu Ser  Gln Ser Phe 
    2000                 2005                 2010             


Tyr Asn  Leu Val Ile Gln Val  His Asp Leu Pro Gln  Pro Pro Thr 
    2015                 2020                 2025             


Ser Arg  Phe Thr Ser Thr Ala  Gln Val Ser Ile Ile  Leu Leu Asp 
    2030                 2035                 2040             


Val Asn  Asp Asn Pro Pro Met  Phe Leu Ser Pro Lys  Leu Thr Tyr 
    2045                 2050                 2055             


Ile Pro  Glu Asn Thr Pro Ile  Asp Thr Val Val Phe  Lys Ala Gln 
    2060                 2065                 2070             


Ala Thr  Asp Pro Asp Ser Gly  Pro Asn Ser Tyr Ile  Glu Tyr Thr 
    2075                 2080                 2085             


Leu Leu  Asn Pro Ser Gly Asn  Lys Phe Ser Ile Gly  Thr Ile Asp 
    2090                 2095                 2100             


Gly Glu  Val His Leu Thr Gly  Glu Leu Asp Arg Glu  Glu Val Ser 
    2105                 2110                 2115             


Asn Tyr  Ser Leu Thr Val Val  Ala Thr Asp Lys Gly  Gln Pro Pro 
    2120                 2125                 2130             


Leu Ser  Ser Ser Thr Glu Val  Val Val Met Val Leu  Asp Ile Asn 
    2135                 2140                 2145             


Asp Asn  Asn Pro Val Phe Ala  Gln Ala Met Tyr Arg  Val Gln Ile 
    2150                 2155                 2160             


Lys Glu  Asn Ile Leu Thr Gly  Thr Asp Ile Ile Gln  Val Ser Ala 
    2165                 2170                 2175             


Ala Asp  Asn Asp Glu Gly Thr  Asn Gly Gln Val Arg  Tyr Gly Ile 
    2180                 2185                 2190             


Val Gly  Gly Asn Thr His Gln  Glu Phe Arg Ile Asp  Ser Val Thr 
    2195                 2200                 2205             


Gly Ala  Ile Thr Val Ala Lys  Ser Leu Asp Arg Glu  Thr Thr Pro 
    2210                 2215                 2220             


Ala Tyr  Thr Leu Thr Val Gln  Ala Thr Asp Arg Gly  Ser Ser Pro 
    2225                 2230                 2235             


Arg Thr  Asp Ser Cys Thr Val  Ala Ile Thr Leu Leu  Asp Met Asn 
    2240                 2245                 2250             


Asp Phe  Val Pro Val Phe Glu  Leu Ser Pro Tyr Ser  Val Asn Val 
    2255                 2260                 2265             


Pro Glu  Asn Leu Gly Thr Leu  Pro Arg Ala Ile Leu  Gln Val Val 
    2270                 2275                 2280             


Ala Arg  Asp Asp Asp Gln Gly  Pro Asn Ser Gln Leu  Ser Tyr Val 
    2285                 2290                 2295             


Leu Leu  Gly Gly Asn Glu Asp  Asn Ala Phe Val Leu  Thr Ala Ser 
    2300                 2305                 2310             


Gly Glu  Leu Arg Val Thr Gln  Ser Leu Asp Arg Glu  Ala Arg Asp 
    2315                 2320                 2325             


His Phe  Val Leu Val Val Thr  Ala Ala Asp Ala Gly  Ser Pro Ala 
    2330                 2335                 2340             


Leu Thr  Gly Thr Gly Thr Ile  Asn Ile Ile Val Asp  Asp Ile Asn 
    2345                 2350                 2355             


Asp Asn  Val Pro Thr Phe Ala  Asn Asn Met Tyr Leu  Thr Ser Ile 
    2360                 2365                 2370             


Ala Glu  Asp Ala Arg Thr Gly  Thr Asp Val Leu Leu  Val Asn Ala 
    2375                 2380                 2385             


Ser Asp  Ala Asp Ala Ala Ala  Asn Ala Val Ile Ser  Tyr Ser Ile 
    2390                 2395                 2400             


Ile Gly  Gly Asn Ser Gln Phe  Thr Ile Asn Pro Ser  Thr Gly Gln 
    2405                 2410                 2415             


Ile Ile  Thr Ser Ala Leu Leu  Asp Arg Glu Thr Lys  Asp Asn Tyr 
    2420                 2425                 2430             


Thr Leu  Val Val Val Ala Ser  Asp Ala Gly Ser Pro  Glu Ser Leu 
    2435                 2440                 2445             


Ser Ser  Ser Thr Ser Val Leu  Val Thr Ile Thr Asp  Val Asn Asp 
    2450                 2455                 2460             


Asn Pro  Pro Arg Phe Gln His  His Pro Tyr Val Thr  His Ile Pro 
    2465                 2470                 2475             


Ser Pro  Thr Pro Pro Gly Ser  Phe Val Phe Ala Val  Thr Val Thr 
    2480                 2485                 2490             


Asp Ala  Asp Ile Gly Ser Asn  Ser Glu Leu His Tyr  Ser Leu Ser 
    2495                 2500                 2505             


Gly Arg  Asn Ser Glu Lys Phe  His Ile Asp Pro Leu  Arg Gly Ala 
    2510                 2515                 2520             


Ile Met  Ala Ala Gly Pro Leu  Ser Gly Ala Ser Glu  Val Thr Phe 
    2525                 2530                 2535             


Ser Val  His Val Lys Asp Gly  Gly Ser Phe Pro Lys  Thr Asp Ser 
    2540                 2545                 2550             


Thr Thr  Val Thr Val Arg Phe  Ala Asn Lys Ala Asp  Phe Pro Lys 
    2555                 2560                 2565             


Val Arg  Ala Lys Glu Gln Thr  Phe Met Phe Pro Glu  Asn Gln Pro 
    2570                 2575                 2580             


Val Gly  Thr Leu Val Thr Thr  Ile Thr Gly Ser Ser  Leu Arg Gly 
    2585                 2590                 2595             


Glu Thr  Leu Ser Tyr Tyr Ile  Ala Ser Gly Asn Leu  Gly Asp Thr 
    2600                 2605                 2610             


Phe Gln  Ile Asp Pro Leu Thr  Gly Gln Val Ser Ile  Ser Gln Pro 
    2615                 2620                 2625             


Leu Asp  Phe Glu Lys Ile Gln  Lys Tyr Val Val Trp  Ile Glu Ala 
    2630                 2635                 2640             


Arg Asp  Gly Gly Phe Pro Pro  Phe Ser Ser Tyr Glu  Lys Leu Asp 
    2645                 2650                 2655             


Ile Thr  Val Leu Asp Ile Asn  Asp Asn Ala Pro Thr  Phe Glu Glu 
    2660                 2665                 2670             


Asp Pro  Phe Val Ser Glu Ile  Leu Glu Asn Leu Ser  Pro Arg Lys 
    2675                 2680                 2685             


Ile Leu  Thr Val Ser Ala Thr  Asp Lys Asp Ser Gly  Pro Asn Gly 
    2690                 2695                 2700             


Gln Leu  Asp Tyr Glu Ile Val  Asn Gly Asn Gln Glu  Ser Ser Phe 
    2705                 2710                 2715             


Thr Ile  Asn His Ala Thr Gly  Glu Ile Arg Ser Ile  Arg Pro Leu 
    2720                 2725                 2730             


Asp Arg  Glu Lys Ile Ser His  Tyr Glu Leu Thr Val  Lys Ser Ser 
    2735                 2740                 2745             


Asp Lys  Gly Ser Pro Ser Gln  Ser Thr Ser Val Lys  Val Ile Ile 
    2750                 2755                 2760             


Ser Ile  Leu Asp Glu Asn Asp  Asn Ala Pro Arg Phe  Ser Gln Ile 
    2765                 2770                 2775             


Phe Ser  Ala Tyr Val Ser Glu  Asn Ser Pro Leu Gly  Tyr Thr Val 
    2780                 2785                 2790             


Thr Arg  Val Thr Thr Ser Asp  Glu Asp Ile Gly Ile  Asn Ala Ile 
    2795                 2800                 2805             


Ser Arg  Tyr Ser Ile Val Asp  Thr Ser Leu Pro Phe  Thr Ile Asn 
    2810                 2815                 2820             


Pro Asn  Thr Gly Asp Ile Val  Ile Ser Arg Pro Leu  Asn Arg Glu 
    2825                 2830                 2835             


Asp Thr  Asp Arg Tyr Arg Ile  Arg Val Ser Ala His  Asp Ser Gly 
    2840                 2845                 2850             


Trp Thr  Val Ser Thr Asp Val  Thr Ile Phe Val Thr  Asp Ile Asn 
    2855                 2860                 2865             


Asp Asn  Thr Pro Arg Phe Ser  Arg Pro Ser Tyr Tyr  Leu Asp Cys 
    2870                 2875                 2880             


Pro Glu  Leu Pro Glu Leu Gly  Ser Arg Val Thr Gln  Val Ser Ala 
    2885                 2890                 2895             


Thr Asp  Pro Asp Glu Gly Ser  Asn Gly Gln Val Phe  Tyr Phe Ile 
    2900                 2905                 2910             


Lys Ser  Gln Ser Glu Tyr Phe  Arg Ile Asn Ala Thr  Thr Gly Glu 
    2915                 2920                 2925             


Ile Phe  Asn Lys Gln Val Leu  Lys Tyr Gln Asn Val  Ser Gly Phe 
    2930                 2935                 2940             


Ser Asn  Val Asn Ile Asn Arg  His Ser Phe Ile Val  Thr Ala Ser 
    2945                 2950                 2955             


Asp Arg  Gly Asn Pro Ser Leu  Leu Ser Glu Thr Thr  Val Thr Ile 
    2960                 2965                 2970             


Asn Thr  Val Asp Ser Asn Asp  Asn Pro Pro Gln Phe  Leu Gln Asn 
    2975                 2980                 2985             


Lys Tyr  Phe Thr Pro Val Thr  Lys Asn Val Lys Val  Gly Thr Lys 
    2990                 2995                 3000             


Leu Ile  Lys Val Thr Ala Val  Asp Asp Lys Asp Phe  Gly Leu Asn 
    3005                 3010                 3015             


Ser Glu  Val Glu Tyr Phe Val  Ser Asp Gly Asn His  Leu Gly Lys 
    3020                 3025                 3030             


Phe Lys  Leu Asp Asn Asp Thr  Gly Trp Ile Ser Ile  Ala Ser Ser 
    3035                 3040                 3045             


Leu Val  Ser Asp Leu Asn Gln  Asn Phe Leu Ile Arg  Val Thr Ala 
    3050                 3055                 3060             


Lys Asp  Lys Gly Asn Pro Pro  Leu Ser Ser Gln Ala  Val Val His 
    3065                 3070                 3075             


Ile Thr  Val Thr Glu Glu Asn  Tyr His Thr Pro Glu  Phe Ser Gln 
    3080                 3085                 3090             


Asn His  Ile Ser Ala Thr Ile  Pro Glu Ser His Ser  Ile Gly Ser 
    3095                 3100                 3105             


Val Val  Arg Thr Val Ser Ala  Arg Asp Arg Asp Thr  Ala Met Asn 
    3110                 3115                 3120             


Gly Leu  Ile Ser Tyr Asn Ile  Ile Ser Gly Asn Glu  Glu Gly Ile 
    3125                 3130                 3135             


Phe Ala  Ile Asn Ser Ser Thr  Gly Val Val Thr Leu  Ala Lys Ala 
    3140                 3145                 3150             


Leu Asp  Tyr Glu Met Ser Ser  Lys His Glu Met Thr  Ile Ser Ala 
    3155                 3160                 3165             


Thr Asp  Gly Gly Trp Val Ala  Arg Thr Gly Tyr Cys  Ser Leu Thr 
    3170                 3175                 3180             


Val Ser  Val Ile Asp Val Asn  Asp Asn Ser Pro Val  Phe Val Pro 
    3185                 3190                 3195             


Asp Glu  Phe Phe Pro Thr Val  Met Glu Asn Ala Pro  Ser Gly Thr 
    3200                 3205                 3210             


Thr Val  Ile His Leu Asn Ala  Thr Asp Ala Asp Ser  Gly Ala Asn 
    3215                 3220                 3225             


Ala Val  Ile Ala Tyr Thr Val  Gln Ser Ser Asp Ser  Asp Leu Phe 
    3230                 3235                 3240             


Val Ile  Asp Pro Asn Met Gly  Val Ile Thr Thr Gln  Gly Phe Leu 
    3245                 3250                 3255             


Asp Phe  Glu Thr Lys Gln Ser  Tyr His Leu Thr Val  Lys Ala Phe 
    3260                 3265                 3270             


Asn Val  Pro Asp Glu Glu Lys  Cys Ser Phe Ala Thr  Val Asp Ile 
    3275                 3280                 3285             


Gln Leu  Lys Gly Thr Asn Glu  Tyr Val Pro Arg Phe  Val Ser Lys 
    3290                 3295                 3300             


Leu Tyr  Tyr Phe Glu Val Ser  Glu Ala Ala Ser Arg  Gly Thr Ala 
    3305                 3310                 3315             


Val Gly  Glu Val Phe Ala Ser  Asp Arg Asp Met Gly  Ala Asp Gly 
    3320                 3325                 3330             


Glu Val  His Tyr Leu Ile Phe  Gly Asn Ser Arg Lys  Lys Gly Phe 
    3335                 3340                 3345             


Gln Ile  Asn Lys Met Thr Gly  Gln Ile Tyr Val Ser  Gly Leu Leu 
    3350                 3355                 3360             


Asp Arg  Glu Lys Glu Glu Arg  Val Ser Leu Lys Val  Leu Ala Lys 
    3365                 3370                 3375             


Asn Phe  Gly Asn Ile Arg Gly  Ala Asp Ile Asp Glu  Val Thr Val 
    3380                 3385                 3390             


Asn Ile  Thr Val Leu Asp Ala  Asn Asp Pro Pro Val  Phe Ser Leu 
    3395                 3400                 3405             


Ser Thr  Tyr Arg Val Gln Ile  Ser Glu Gly Val Pro  Ile Gly Thr 
    3410                 3415                 3420             


His Val  Thr Phe Val Ser Ala  Phe Asp Ser Asp Ser  Ile Pro Ser 
    3425                 3430                 3435             


Trp Ser  Arg Phe Ser Tyr Phe  Ile Gly Ser Gly Asn  Glu Asn Gly 
    3440                 3445                 3450             


Ala Phe  Ser Ile Asn Pro Gln  Thr Gly Gln Ile Thr  Val Thr Ser 
    3455                 3460                 3465             


Gly Leu  Asp Arg Glu Ser Leu  Pro Val Tyr Asn Leu  Thr Val Leu 
    3470                 3475                 3480             


Ala Val  Asp Ser Gly Thr Pro  Ser Ala Thr Gly Ser  Ala Ser Leu 
    3485                 3490                 3495             


Val Val  Thr Leu Glu Asp Ile  Asn Asp Asn Gly Pro  Val Leu Thr 
    3500                 3505                 3510             


Val Ser  Glu Gly Glu Val Leu  Glu Asn Lys Arg Pro  Gly Thr Leu 
    3515                 3520                 3525             


Val Met  Thr Leu Gln Ser Thr  Asp Pro Asp Leu Pro  Pro Asn Gln 
    3530                 3535                 3540             


Gly Pro  Phe Asn Tyr Tyr Leu  Leu Ser Thr Gly Pro  Ala Thr Asn 
    3545                 3550                 3555             


Tyr Phe  Ser Leu Ser Thr Ala  Gly Val Leu Ser Thr  Thr Arg Glu 
    3560                 3565                 3570             


Ile Asp  Arg Glu Gln Ile Ala  Asp Phe Tyr Leu Ser  Val Val Thr 
    3575                 3580                 3585             


Arg Asp  Ser Gly Ala Pro Gln  Met Ser Ser Thr Gly  Thr Val His 
    3590                 3595                 3600             


Ile Thr  Val Leu Asp Gln Asn  Asp Asn Pro Ser Gln  Ser Arg Thr 
    3605                 3610                 3615             


Val Glu  Ile Phe Val Asn Tyr  Tyr Gly Asn Leu Phe  Pro Gly Gly 
    3620                 3625                 3630             


Thr Leu  Gly Ser Val Lys Pro  Gln Asp Pro Asp Val  Leu Asp Ser 
    3635                 3640                 3645             


Phe His  Cys Ser Leu Thr Ser  Gly Val Thr Ser Leu  Phe Ser Ile 
    3650                 3655                 3660             


Pro Ala  Gly Ser Cys Asp Leu  Ser Ser Gln Pro Arg  Ser Thr Asp 
    3665                 3670                 3675             


Gly Thr  Phe Asp Leu Thr Val  Val Ser Ser Asp Gly  Val His Ser 
    3680                 3685                 3690             


Thr Val  Thr Asn Asn Ile Arg  Val Phe Phe Ala Gly  Phe Ser Asn 
    3695                 3700                 3705             


Ala Thr  Ile Asp Asn Ser Ile  Leu Leu Arg Val Gly  Val Pro Thr 
    3710                 3715                 3720             


Val Lys  Asp Phe Leu Thr Asn  His Tyr Leu His Phe  Leu Arg Ile 
    3725                 3730                 3735             


Ala Ser  Ser Gln Leu Thr Gly  Leu Gly Thr Ala Val  Gln Leu Tyr 
    3740                 3745                 3750             


Ala Ala  Tyr Glu Glu Asn Asn  Arg Thr Phe Leu Leu  Ala Ala Val 
    3755                 3760                 3765             


Lys Arg  Asn Asn Asn Gln Tyr  Val Asn Pro Ser Gly  Val Ala Thr 
    3770                 3775                 3780             


Phe Phe  Glu Ser Ile Lys Glu  Ile Leu Leu Arg Gln  Ser Gly Val 
    3785                 3790                 3795             


Lys Val  Glu Ser Val Asp His  Asp Pro Cys Ile His  Gly Pro Cys 
    3800                 3805                 3810             


Gln Asn  Gly Gly Ser Cys Leu  Arg Arg Leu Ala Val  Gly Ser Ala 
    3815                 3820                 3825             


Leu Lys  Ile Gln Glu Ser Leu  Pro Val Ile Ile Val  Ala Asn Glu 
    3830                 3835                 3840             


Pro Leu  Gln Pro Ser Gln Cys  Lys Cys Val Pro Gly  Tyr Ala Gly 
    3845                 3850                 3855             


Ser Trp  Cys Glu Val Asp Ile  Asp Glu Cys Leu Pro  Ala Pro Cys 
    3860                 3865                 3870             


His Asn  Gly Gly Thr Cys His  Asn Leu Val Gly Gly  Phe Ser Cys 
    3875                 3880                 3885             


Ser Cys  Pro Glu Gly Phe Thr  Gly Arg Ala Cys Glu  Arg Asp Ile 
    3890                 3895                 3900             


Asn Glu  Cys Leu Pro Ser Pro  Cys Lys His Gly Ala  Val Cys Gln 
    3905                 3910                 3915             


Asn Phe  Pro Gly Gly Phe Asn  Cys Val Cys Lys Thr  Gly Tyr Thr 
    3920                 3925                 3930             


Gly Lys  Met Cys Glu Ser Ser  Val Asn Tyr Cys Glu  Cys Asn Pro 
    3935                 3940                 3945             


Cys Phe  Asn Gly Gly Ser Cys  Gln Ser Gly Val Glu  Ser Tyr Tyr 
    3950                 3955                 3960             


Cys His  Cys Pro Phe Gly Val  Phe Gly Lys His Cys  Glu Leu Asn 
    3965                 3970                 3975             


Ser Tyr  Gly Phe Glu Glu Leu  Ser Tyr Met Glu Phe  Pro Ser Leu 
    3980                 3985                 3990             


Asp Pro  Asn Asn Asn Tyr Ile  Tyr Val Lys Phe Ala  Thr Ile Lys 
    3995                 4000                 4005             


Ser His  Ala Leu Leu Leu Tyr  Asn Tyr Asp Asn Gln  Thr Gly Glu 
    4010                 4015                 4020             


Arg Ala  Glu Phe Leu Ala Leu  Glu Ile Ala Glu Glu  Arg Leu Arg 
    4025                 4030                 4035             


Phe Ser  Tyr Asn Leu Gly Ser  Gly Thr Tyr Lys Leu  Thr Thr Met 
    4040                 4045                 4050             


Lys Lys  Val Ser Asp Gly Gln  Phe His Thr Val Ile  Ala Arg Arg 
    4055                 4060                 4065             


Ala Gly  Met Ala Ala Ser Leu  Thr Val Asp Ser Cys  Ser Glu Asn 
    4070                 4075                 4080             


Gln Glu  Pro Gly Tyr Cys Thr  Val Ser Asn Val Ala  Val Ser Asp 
    4085                 4090                 4095             


Asp Trp  Thr Leu Asp Val Gln  Pro Asn Arg Val Thr  Val Gly Gly 
    4100                 4105                 4110             


Ile Arg  Ser Leu Glu Pro Ile  Leu Gln Arg Arg Gly  His Val Glu 
    4115                 4120                 4125             


Ser His  Asp Phe Val Gly Cys  Val Met Glu Phe Ala  Val Asn Gly 
    4130                 4135                 4140             


Arg Pro  Leu Glu Pro Ser Gln  Ala Leu Ala Ala Gln  Gly Ile Leu 
    4145                 4150                 4155             


Asp Gln  Cys Pro Arg Leu Glu  Gly Thr Cys Ala Arg  Asn Pro Cys 
    4160                 4165                 4170             


Gln His  Gly Gly Thr Cys Val  Asp Phe Trp Ser Trp  Gln Gln Cys 
    4175                 4180                 4185             


Gln Cys  Met Glu Gly Leu Thr  Gly Lys Tyr Cys Glu  Lys Ser Val 
    4190                 4195                 4200             


Thr Pro  Asp Thr Ala Leu Ser  Leu Glu Gly Lys Gly  Arg Leu Asp 
    4205                 4210                 4215             


Tyr His  Met Ser Gln Ser Glu  Lys Arg Glu Tyr Leu  Leu Thr Gln 
    4220                 4225                 4230             


Ser Ile  Arg Asp Thr Thr Leu  Glu Pro Phe Gly Val  Asn Ser Leu 
    4235                 4240                 4245             


Glu Val  Lys Phe Arg Thr Arg  Ser Glu Asn Gly Ile  Leu Ile His 
    4250                 4255                 4260             


Ile Gln  Glu Ser Ser Asn Tyr  Thr Thr Val Lys Ile  Lys Asn Gly 
    4265                 4270                 4275             


Lys Val  His Phe Thr Ser Asp  Ala Gly Val Ala Gly  Lys Val Glu 
    4280                 4285                 4290             


Arg Ile  Ile Pro Glu Ala Tyr  Ile Ala Asp Gly His  Trp His Thr 
    4295                 4300                 4305             


Phe Arg  Ile Ser Lys Asn Gly  Ser Ile Thr Val Leu  Ser Val Asp 
    4310                 4315                 4320             


Arg Ile  His Asn Arg Asp Ile  Val His Pro Thr Gln  Asp Phe Gly 
    4325                 4330                 4335             


Gly Ile  Glu Val Leu Ser Met  Ser Leu Gly Gly Ile  Pro Pro Asn 
    4340                 4345                 4350             


Gln Ala  His Arg Asp Thr Gln  Thr Gly Phe Asn Gly  Cys Ile Ala 
    4355                 4360                 4365             


Ser Val  Leu Tyr Gly Gly Glu  Ser Leu Pro Phe Ser  Gly Lys His 
    4370                 4375                 4380             


Ser Leu  Ala Ser Ile Ser Lys  Thr Asp Pro Ser Val  Lys Ile Gly 
    4385                 4390                 4395             


Cys Arg  Gly Pro Asn Ile Cys  Ala Ser Asn Pro Cys  Trp Gly Asp 
    4400                 4405                 4410             


Leu Leu  Cys Ile Asn Gln Trp  Tyr Ala Tyr Lys Cys  Val Pro Pro 
    4415                 4420                 4425             


Gly Asp  Cys Ala Ser His Pro  Cys Gln Asn Gly Gly  Ser Cys Glu 
    4430                 4435                 4440             


Pro Gly  Leu Leu Ser Gly Tyr  Thr Cys Ser Cys Pro  Glu Ser His 
    4445                 4450                 4455             


Thr Gly  Arg Thr Cys Glu Thr  Val Val Ala Cys Leu  Gly Val Leu 
    4460                 4465                 4470             


Cys Pro  Gln Gly Lys Val Cys  Lys Ala Gly Ser Pro  Gly Gly His 
    4475                 4480                 4485             


Val Cys  Val Gln Ser Gln Gly  Pro Asp Glu Ile Ser  Leu Pro Leu 
    4490                 4495                 4500             


Trp Ala  Val Pro Ala Ile Val  Gly Ser Cys Ala Thr  Ala Leu Ala 
    4505                 4510                 4515             


Leu Leu  Val Leu Ser Leu Ile  Leu Cys Asn Gln Cys  Arg Gly Lys 
    4520                 4525                 4530             


Met Pro  Lys Asn Pro Lys Glu  Glu Lys Lys Pro Lys  Glu Lys Lys 
    4535                 4540                 4545             


Lys Lys  Gly Ser Glu Asn Val  Ala Phe Asp Asp Pro  Asp Asn Ile 
    4550                 4555                 4560             


Pro Pro  Tyr Gly Asp Asp Leu  Ala Val Arg Lys Gln  Pro Glu Gly 
    4565                 4570                 4575             


Asn Pro  Lys Pro Asp Ile Ile  Glu Arg Glu Asn Pro  Tyr Leu Ile 
    4580                 4585                 4590             


Phe Asp  Glu Thr Asp Ile Pro  His Asn Ser Glu Thr  Ile Pro Ser 
    4595                 4600                 4605             


Ala Pro  Leu Ala Ser Pro Glu  Gln Glu Ile Glu His  Tyr Asp Ile 
    4610                 4615                 4620             


Asp Asn  Ala Ser Ser Ile Ala  Pro Ser Asp Ala Asp  Ile Ile Gln 
    4625                 4630                 4635             


His Tyr  Lys Gln Phe Arg Ser  His Thr Pro Lys Phe  Ser Ile Gln 
    4640                 4645                 4650             


Arg His  Ser Pro Leu Gly Phe  Ala Arg Gln Ser Pro  Met Pro Leu 
    4655                 4660                 4665             


Gly Ala  Ser Ser Leu Thr Tyr  Gln Pro Ser Ser Tyr  Gly Gln Gly 
    4670                 4675                 4680             


Leu Arg  Thr Ser Ser Leu Ser  His Ser Ala Cys Pro  Thr Pro Asn 
    4685                 4690                 4695             


Pro Leu  Ser Arg His Ser Pro  Ala Pro Phe Ser Lys  Pro Ser Ala 
    4700                 4705                 4710             


Phe Tyr  Arg Asn Ser Pro Ala  Arg Glu Leu His Leu  Pro Leu Arg 
    4715                 4720                 4725             


Asp Gly  Gly Thr Leu Glu Met  His Gly Asp Pro Cys  Gln Pro Gly 
    4730                 4735                 4740             


Met Phe  Asn Tyr Ala Thr Arg  Leu Gly Arg Arg Ser  Lys Ser Pro 
    4745                 4750                 4755             


Gln Ala  Met Ala Ser His Gly  Ser Arg Pro Gly Ser  Arg Leu Lys 
    4760                 4765                 4770             


Gln Pro  Ile Ala Gln Ile Pro  Leu Glu Ser Ser Pro  Pro Val Gly 
    4775                 4780                 4785             


Leu Ser  Ile Glu Glu Val Glu  Arg Leu Asn Thr Pro  Arg Pro Arg 
    4790                 4795                 4800             


Asn Pro  Ser Ile Cys Ser Ala  Asp His Gly Arg Ser  Ser Ser Glu 
    4805                 4810                 4815             


Glu Asp  Cys Arg Arg Pro Leu  Ser Arg Thr Arg Asn  Pro Ala Asp 
    4820                 4825                 4830             


Gly Ile  Pro Ala Pro Glu Ser  Ser Ser Asp Ser Asp  Ser His Asp 
    4835                 4840                 4845             


Ser Phe  Thr Cys Ser Glu Met  Glu Tyr Asp Arg Glu  Lys Pro Val 
    4850                 4855                 4860             


Val Tyr  Thr Ser Arg Met Pro  Lys Leu Ser Gln Val  Asn Glu Ser 
    4865                 4870                 4875             


Asp Ala  Asp Asp Glu Asp Asn  Tyr Gly Ala Arg Leu  Lys Pro Arg 
    4880                 4885                 4890             


Arg Tyr  His Gly Arg Arg Ala  Glu Gly Gly Pro Val  Gly Thr Pro 
    4895                 4900                 4905             


Ala Ala  Ala Ser Gly Ala Ala  Asp Ser Thr Leu Lys  Leu Gly Gln 
    4910                 4915                 4920             


Gln Ala  Gly Asn Phe Asn Trp  Asp Asn Leu Leu Asn  Trp Gly Pro 
    4925                 4930                 4935             


Gly Phe  Gly His Tyr Val Asp  Val Phe Lys Asp Leu  Ala Ser Leu 
    4940                 4945                 4950             


Pro Glu  Lys Ala Ala Gly Asn  Glu Glu Gly Lys Ser  Gly Ala Ala 
    4955                 4960                 4965             


Lys Pro  Ala Ala Lys Asp Gly  Glu Ala Glu Gln Tyr  Val 
    4970                 4975                 4980     


<210>  5
<211>  4983
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  human Fat4 protein

<400>  5

Met Asp Leu Ala Pro Asp Arg Ala Thr Gly Arg Pro Trp Leu Pro Leu 
1               5                   10                  15      


His Thr Leu Ser Val Ser Gln Leu Leu Arg Val Phe Trp Leu Leu Ser 
            20                  25                  30          


Leu Leu Pro Gly Gln Ala Trp Val His Gly Ala Glu Pro Arg Gln Val 
        35                  40                  45              


Phe Gln Val Leu Glu Glu Gln Pro Pro Gly Thr Leu Val Gly Thr Ile 
    50                  55                  60                  


Gln Thr Arg Pro Gly Phe Thr Tyr Arg Leu Ser Glu Ser His Ala Leu 
65                  70                  75                  80  


Phe Ala Ile Asn Ser Ser Thr Gly Ala Leu Tyr Thr Thr Ser Thr Ile 
                85                  90                  95      


Asp Arg Glu Ser Leu Pro Ser Asp Val Ile Asn Leu Val Val Leu Ser 
            100                 105                 110         


Ser Ala Pro Thr Tyr Pro Thr Glu Val Arg Val Leu Val Arg Asp Leu 
        115                 120                 125             


Asn Asp Asn Ala Pro Val Phe Pro Asp Pro Ser Ile Val Val Thr Phe 
    130                 135                 140                 


Lys Glu Asp Ser Ser Ser Gly Arg Gln Val Ile Leu Asp Thr Ala Thr 
145                 150                 155                 160 


Asp Ser Asp Ile Gly Ser Asn Gly Val Asp His Arg Ser Tyr Arg Ile 
                165                 170                 175     


Ile Arg Gly Asn Glu Ala Gly Arg Phe Arg Leu Asp Ile Thr Leu Asn 
            180                 185                 190         


Pro Ser Gly Glu Gly Ala Phe Leu His Leu Val Ser Lys Gly Gly Leu 
        195                 200                 205             


Asp Arg Glu Val Thr Pro Gln Tyr Gln Leu Leu Val Glu Val Glu Asp 
    210                 215                 220                 


Lys Gly Glu Pro Lys Arg Arg Gly Tyr Leu Gln Val Asn Val Thr Val 
225                 230                 235                 240 


Gln Asp Ile Asn Asp Asn Pro Pro Val Phe Gly Ser Ser His Tyr Gln 
                245                 250                 255     


Ala Gly Val Pro Glu Asp Ala Val Val Gly Ser Ser Val Leu Gln Val 
            260                 265                 270         


Ala Ala Ala Asp Ala Asp Glu Gly Thr Asn Ala Asp Ile Arg Tyr Arg 
        275                 280                 285             


Leu Gln Asp Glu Gly Thr Pro Phe Gln Met Asp Pro Glu Thr Gly Leu 
    290                 295                 300                 


Ile Thr Val Arg Glu Pro Leu Asp Phe Glu Ala Arg Arg Gln Tyr Ser 
305                 310                 315                 320 


Leu Thr Val Gln Ala Met Asp Arg Gly Val Pro Ser Leu Thr Gly Arg 
                325                 330                 335     


Ala Glu Ala Leu Ile Gln Leu Leu Asp Val Asn Asp Asn Asp Pro Val 
            340                 345                 350         


Val Lys Phe Arg Tyr Phe Pro Ala Thr Ser Arg Tyr Ala Ser Val Asp 
        355                 360                 365             


Glu Asn Ala Gln Val Gly Thr Val Val Ala Leu Leu Thr Val Thr Asp 
    370                 375                 380                 


Ala Asp Ser Pro Ala Ala Asn Gly Asn Ile Ser Val Gln Ile Leu Gly 
385                 390                 395                 400 


Gly Asn Glu Gln Arg His Phe Glu Val Gln Ser Ser Lys Val Pro Asn 
                405                 410                 415     


Leu Ser Leu Ile Lys Val Ala Ser Ala Leu Asp Arg Glu Arg Ile Pro 
            420                 425                 430         


Ser Tyr Asn Leu Thr Val Ser Val Ser Asp Asn Tyr Gly Ala Pro Pro 
        435                 440                 445             


Gly Ala Ala Val Gln Ala Arg Ser Ser Val Ala Ser Leu Val Ile Phe 
    450                 455                 460                 


Val Asn Asp Ile Asn Asp His Pro Pro Val Phe Ser Gln Gln Val Tyr 
465                 470                 475                 480 


Arg Val Asn Leu Ser Glu Glu Ala Pro Pro Gly Ser Tyr Val Ser Gly 
                485                 490                 495     


Ile Ser Ala Thr Asp Gly Asp Ser Gly Leu Asn Ala Asn Leu Arg Tyr 
            500                 505                 510         


Ser Ile Val Ser Gly Asn Gly Leu Gly Trp Phe His Ile Ser Glu His 
        515                 520                 525             


Ser Gly Leu Val Thr Thr Gly Ser Ser Gly Gly Leu Asp Arg Glu Leu 
    530                 535                 540                 


Ala Ser Gln Ile Val Leu Asn Ile Ser Ala Arg Asp Gln Gly Val His 
545                 550                 555                 560 


Pro Lys Val Ser Tyr Ala Gln Leu Val Val Thr Leu Leu Asp Val Asn 
                565                 570                 575     


Asp Glu Lys Pro Val Phe Ser Gln Pro Glu Gly Tyr Asp Val Ser Val 
            580                 585                 590         


Val Glu Asn Ala Pro Thr Gly Thr Glu Leu Leu Met Leu Arg Ala Thr 
        595                 600                 605             


Asp Gly Asp Leu Gly Asp Asn Gly Thr Val Arg Phe Ser Leu Gln Glu 
    610                 615                 620                 


Ala Glu Thr Asp Arg Arg Ser Phe Arg Leu Asp Pro Val Ser Gly Arg 
625                 630                 635                 640 


Leu Ser Thr Ile Ser Ser Leu Asp Arg Glu Glu Gln Ala Phe Tyr Ser 
                645                 650                 655     


Leu Leu Val Leu Ala Thr Asp Leu Gly Ser Pro Pro Gln Ser Ser Met 
            660                 665                 670         


Ala Arg Ile Asn Val Ser Leu Leu Asp Ile Asn Asp Asn Ser Pro Val 
        675                 680                 685             


Phe Tyr Pro Val Gln Tyr Phe Ala His Ile Lys Glu Asn Glu Pro Gly 
    690                 695                 700                 


Gly Ser Tyr Ile Thr Thr Val Ser Ala Thr Asp Pro Asp Leu Gly Thr 
705                 710                 715                 720 


Asn Gly Thr Val Lys Tyr Ser Ile Ser Ala Gly Asp Arg Ser Arg Phe 
                725                 730                 735     


Gln Val Asn Ala Gln Ser Gly Val Ile Ser Thr Arg Met Ala Leu Asp 
            740                 745                 750         


Arg Glu Glu Lys Thr Ala Tyr Gln Leu Gln Ile Val Ala Thr Asp Gly 
        755                 760                 765             


Gly Asn Leu Gln Ser Pro Asn Gln Ala Ile Val Thr Ile Thr Val Leu 
    770                 775                 780                 


Asp Thr Gln Asp Asn Pro Pro Val Phe Ser Gln Val Ala Tyr Ser Phe 
785                 790                 795                 800 


Val Val Phe Glu Asn Val Ala Leu Gly Tyr His Val Gly Ser Val Ser 
                805                 810                 815     


Ala Ser Thr Met Asp Leu Asn Ser Asn Ile Ser Tyr Leu Ile Thr Thr 
            820                 825                 830         


Gly Asp Gln Lys Gly Met Phe Ala Ile Asn Gln Val Thr Gly Gln Leu 
        835                 840                 845             


Thr Thr Ala Asn Val Ile Asp Arg Glu Glu Gln Ser Phe Tyr Gln Leu 
    850                 855                 860                 


Lys Val Val Ala Ser Gly Gly Thr Val Thr Gly Asp Thr Met Val Asn 
865                 870                 875                 880 


Ile Thr Val Lys Asp Leu Asn Asp Asn Ser Pro His Phe Leu Gln Ala 
                885                 890                 895     


Ile Glu Ser Val Asn Val Val Glu Asn Trp Gln Ala Gly His Ser Ile 
            900                 905                 910         


Phe Gln Ala Lys Ala Val Asp Pro Asp Glu Gly Val Asn Gly Met Val 
        915                 920                 925             


Leu Tyr Ser Leu Lys Gln Asn Pro Lys Asn Leu Phe Ala Ile Asn Glu 
    930                 935                 940                 


Lys Asn Gly Thr Ile Ser Leu Leu Gly Pro Leu Asp Val His Ala Gly 
945                 950                 955                 960 


Ser Tyr Gln Ile Glu Ile Leu Ala Ser Asp Met Gly Val Pro Gln Leu 
                965                 970                 975     


Ser Ser Ser Val Ile Leu Thr Val Tyr Val His Asp Val Asn Asp Asn 
            980                 985                 990         


Ser Pro Val Phe Asp Gln Leu Ser  Tyr Glu Val Thr Leu  Ser Glu Ser 
        995                 1000                 1005             


Glu Pro  Val Asn Ser Arg Phe  Phe Lys Val Gln Ala  Ser Asp Lys 
    1010                 1015                 1020             


Asp Ser  Gly Ala Asn Gly Glu  Ile Ala Tyr Thr Ile  Ala Glu Gly 
    1025                 1030                 1035             


Asn Thr  Gly Asp Ala Phe Gly  Ile Phe Pro Asp Gly  Gln Leu Tyr 
    1040                 1045                 1050             


Ile Lys  Ser Glu Leu Asp Arg  Glu Leu Gln Asp Arg  Tyr Val Leu 
    1055                 1060                 1065             


Met Val  Val Ala Ser Asp Arg  Ala Val Glu Pro Leu  Ser Ala Thr 
    1070                 1075                 1080             


Val Asn  Val Thr Val Ile Leu  Glu Asp Val Asn Asp  Asn Arg Pro 
    1085                 1090                 1095             


Leu Phe  Asn Ser Thr Asn Tyr  Thr Phe Tyr Phe Glu  Glu Glu Gln 
    1100                 1105                 1110             


Arg Ala  Gly Ser Phe Val Gly  Lys Val Ser Ala Val  Asp Lys Asp 
    1115                 1120                 1125             


Phe Gly  Pro Asn Gly Glu Val  Arg Tyr Ser Phe Glu  Met Val Gln 
    1130                 1135                 1140             


Pro Asp  Phe Glu Leu His Ala  Ile Ser Gly Glu Ile  Thr Asn Thr 
    1145                 1150                 1155             


His Gln  Phe Asp Arg Glu Ser  Leu Met Arg Arg Arg  Gly Thr Ala 
    1160                 1165                 1170             


Val Phe  Ser Phe Thr Val Ile  Ala Thr Asp Gln Gly  Ile Pro Gln 
    1175                 1180                 1185             


Pro Leu  Lys Asp Gln Ala Thr  Val His Val Tyr Met  Lys Asp Ile 
    1190                 1195                 1200             


Asn Asp  Asn Ala Pro Lys Phe  Leu Lys Asp Phe Tyr  Gln Ala Thr 
    1205                 1210                 1215             


Ile Ser  Glu Ser Ala Ala Asn  Leu Thr Gln Val Leu  Arg Val Ser 
    1220                 1225                 1230             


Ala Ser  Asp Val Asp Glu Gly  Asn Asn Gly Leu Ile  His Tyr Ser 
    1235                 1240                 1245             


Ile Ile  Lys Gly Asn Glu Glu  Arg Gln Phe Ala Ile  Asp Ser Thr 
    1250                 1255                 1260             


Ser Gly  Gln Val Thr Leu Ile  Gly Lys Leu Asp Tyr  Glu Ala Thr 
    1265                 1270                 1275             


Pro Ala  Tyr Ser Leu Val Ile  Gln Ala Val Asp Ser  Gly Thr Ile 
    1280                 1285                 1290             


Pro Leu  Asn Ser Thr Cys Thr  Leu Asn Ile Asp Ile  Leu Asp Glu 
    1295                 1300                 1305             


Asn Asp  Asn Thr Pro Ser Phe  Pro Lys Ser Thr Leu  Phe Val Asp 
    1310                 1315                 1320             


Val Leu  Glu Asn Met Arg Ile  Gly Glu Leu Val Ser  Ser Val Thr 
    1325                 1330                 1335             


Ala Thr  Asp Ser Asp Ser Gly  Asp Asn Ala Asp Leu  Tyr Tyr Ser 
    1340                 1345                 1350             


Ile Thr  Gly Thr Asn Asn His  Gly Thr Phe Ser Ile  Ser Pro Asn 
    1355                 1360                 1365             


Thr Gly  Ser Ile Phe Leu Ala  Lys Lys Leu Asp Phe  Glu Thr Gln 
    1370                 1375                 1380             


Ser Leu  Tyr Lys Leu Asn Ile  Thr Ala Lys Asp Gln  Gly Arg Pro 
    1385                 1390                 1395             


Pro Arg  Ser Ser Thr Met Ser  Val Val Ile His Val  Arg Asp Phe 
    1400                 1405                 1410             


Asn Asp  Asn Pro Pro Ser Phe  Pro Pro Gly Asp Ile  Phe Lys Ser 
    1415                 1420                 1425             


Ile Val  Glu Asn Ile Pro Ile  Gly Thr Ser Val Ile  Ser Val Thr 
    1430                 1435                 1440             


Ala His  Asp Pro Asp Ala Asp  Ile Asn Gly Gln Leu  Ser Tyr Thr 
    1445                 1450                 1455             


Ile Ile  Gln Gln Met Pro Arg  Gly Asn His Phe Thr  Ile Asp Glu 
    1460                 1465                 1470             


Val Lys  Gly Thr Ile Tyr Thr  Asn Ala Glu Ile Asp  Arg Glu Phe 
    1475                 1480                 1485             


Ala Asn  Leu Phe Glu Leu Thr  Val Lys Ala Asn Asp  Gln Ala Val 
    1490                 1495                 1500             


Pro Ile  Glu Thr Arg Arg Tyr  Ala Leu Lys Asn Val  Thr Ile Leu 
    1505                 1510                 1515             


Val Thr  Asp Leu Asn Asp Asn  Val Pro Met Phe Ile  Ser Gln Asn 
    1520                 1525                 1530             


Ala Leu  Ala Ala Asp Pro Ser  Ala Val Ile Gly Ser  Val Leu Thr 
    1535                 1540                 1545             


Thr Ile  Met Ala Ala Asp Pro  Asp Glu Gly Ala Asn  Gly Glu Ile 
    1550                 1555                 1560             


Glu Tyr  Glu Ile Ile Asn Gly  Asp Thr Asp Thr Phe  Ile Val Asp 
    1565                 1570                 1575             


Arg Tyr  Ser Gly Asp Leu Arg  Val Ala Ser Ala Leu  Val Pro Ser 
    1580                 1585                 1590             


Gln Leu  Ile Tyr Asn Leu Ile  Val Ser Ala Thr Asp  Leu Gly Pro 
    1595                 1600                 1605             


Glu Arg  Arg Lys Ser Thr Thr  Glu Leu Thr Ile Ile  Leu Gln Gly 
    1610                 1615                 1620             


Leu Asp  Gly Pro Val Phe Thr  Gln Pro Lys Tyr Ile  Thr Ile Leu 
    1625                 1630                 1635             


Lys Glu  Gly Glu Pro Ile Gly  Thr Asn Val Ile Ser  Ile Glu Ala 
    1640                 1645                 1650             


Ala Ser  Pro Arg Gly Ser Glu  Ala Pro Val Glu Tyr  Tyr Ile Val 
    1655                 1660                 1665             


Ser Val  Arg Cys Glu Glu Lys  Thr Val Gly Arg Leu  Phe Thr Ile 
    1670                 1675                 1680             


Gly Arg  His Thr Gly Ile Ile  Gln Thr Ala Ala Ile  Leu Asp Arg 
    1685                 1690                 1695             


Glu Gln  Gly Ala Cys Leu Tyr  Leu Val Asp Val Tyr  Ala Ile Glu 
    1700                 1705                 1710             


Lys Ser  Thr Ala Phe Pro Arg  Thr Gln Arg Ala Glu  Val Glu Ile 
    1715                 1720                 1725             


Thr Leu  Gln Asp Ile Asn Asp  Asn Pro Pro Val Phe  Pro Thr Asp 
    1730                 1735                 1740             


Met Leu  Asp Leu Thr Val Glu  Glu Asn Ile Gly Asp  Gly Ser Lys 
    1745                 1750                 1755             


Ile Met  Gln Leu Thr Ala Met  Asp Ala Asp Glu Gly  Ala Asn Ala 
    1760                 1765                 1770             


Leu Val  Thr Tyr Thr Ile Ile  Ser Gly Ala Asp Asp  Ser Phe Arg 
    1775                 1780                 1785             


Ile Asp  Pro Glu Ser Gly Asp  Leu Ile Ala Thr Arg  Arg Leu Asp 
    1790                 1795                 1800             


Arg Glu  Arg Arg Ser Lys Tyr  Ser Leu Leu Val Arg  Ala Asp Asp 
    1805                 1810                 1815             


Gly Leu  Gln Ser Ser Asp Met  Arg Ile Asn Ile Thr  Val Ser Asp 
    1820                 1825                 1830             


Val Asn  Asp His Thr Pro Lys  Phe Ser Arg Pro Val  Tyr Ser Phe 
    1835                 1840                 1845             


Asp Ile  Pro Glu Asp Thr Ile  Pro Gly Ser Leu Val  Ala Ala Ile 
    1850                 1855                 1860             


Leu Ala  Thr Asp Asp Asp Ser  Gly Val Asn Gly Glu  Ile Thr Tyr 
    1865                 1870                 1875             


Ile Val  Asn Glu Asp Asp Glu  Asp Gly Ile Phe Phe  Leu Asn Pro 
    1880                 1885                 1890             


Ile Thr  Gly Val Phe Asn Leu  Thr Arg Leu Leu Asp  Tyr Glu Val 
    1895                 1900                 1905             


Gln Gln  Tyr Tyr Ile Leu Thr  Val Arg Ala Glu Asp  Gly Gly Gly 
    1910                 1915                 1920             


Gln Phe  Thr Thr Ile Arg Val  Tyr Phe Asn Ile Leu  Asp Val Asn 
    1925                 1930                 1935             


Asp Asn  Pro Pro Ile Phe Ser  Leu Asn Ser Tyr Ser  Thr Ser Leu 
    1940                 1945                 1950             


Met Glu  Asn Leu Pro Val Gly  Ser Thr Val Leu Val  Phe Asn Val 
    1955                 1960                 1965             


Thr Asp  Ala Asp Asp Gly Ile  Asn Ser Gln Leu Thr  Tyr Ser Ile 
    1970                 1975                 1980             


Ala Ser  Gly Asp Ser Leu Gly  Gln Phe Thr Val Asp  Lys Asn Gly 
    1985                 1990                 1995             


Val Leu  Lys Val Leu Lys Ala  Leu Asp Arg Glu Ser  Gln Ser Phe 
    2000                 2005                 2010             


Tyr Asn  Leu Val Val Gln Val  His Asp Leu Pro Gln  Ile Pro Ala 
    2015                 2020                 2025             


Ser Arg  Phe Thr Ser Thr Ala  Gln Val Ser Ile Ile  Leu Leu Asp 
    2030                 2035                 2040             


Val Asn  Asp Asn Pro Pro Thr  Phe Leu Ser Pro Lys  Leu Thr Tyr 
    2045                 2050                 2055             


Ile Pro  Glu Asn Thr Pro Ile  Asp Thr Val Val Phe  Lys Ala Gln 
    2060                 2065                 2070             


Ala Thr  Asp Pro Asp Ser Gly  Pro Asn Ser Tyr Ile  Glu Tyr Thr 
    2075                 2080                 2085             


Leu Leu  Asn Pro Leu Gly Asn  Lys Phe Ser Ile Gly  Thr Ile Asp 
    2090                 2095                 2100             


Gly Glu  Val Arg Leu Thr Gly  Glu Leu Asp Arg Glu  Glu Val Ser 
    2105                 2110                 2115             


Asn Tyr  Thr Leu Thr Val Val  Ala Thr Asp Lys Gly  Gln Pro Ser 
    2120                 2125                 2130             


Leu Ser  Ser Ser Thr Glu Val  Val Val Met Val Leu  Asp Ile Asn 
    2135                 2140                 2145             


Asp Asn  Asn Pro Ile Phe Ala  Gln Ala Leu Tyr Lys  Val Glu Ile 
    2150                 2155                 2160             


Asn Glu  Asn Thr Leu Thr Gly  Thr Asp Ile Ile Gln  Val Phe Ala 
    2165                 2170                 2175             


Ala Asp  Gly Asp Glu Gly Thr  Asn Gly Gln Val Arg  Tyr Gly Ile 
    2180                 2185                 2190             


Val Asn  Gly Asn Thr Asn Gln  Glu Phe Arg Ile Asp  Ser Val Thr 
    2195                 2200                 2205             


Gly Ala  Ile Thr Val Ala Lys  Pro Leu Asp Arg Glu  Lys Thr Pro 
    2210                 2215                 2220             


Thr Tyr  His Leu Thr Val Gln  Ala Thr Asp Arg Gly  Ser Thr Pro 
    2225                 2230                 2235             


Arg Thr  Asp Thr Ser Thr Val  Ser Ile Val Leu Leu  Asp Ile Asn 
    2240                 2245                 2250             


Asp Phe  Val Pro Val Phe Glu  Leu Ser Pro Tyr Ser  Val Asn Val 
    2255                 2260                 2265             


Pro Glu  Asn Leu Gly Thr Leu  Pro Arg Thr Ile Leu  Gln Val Val 
    2270                 2275                 2280             


Ala Arg  Asp Asp Asp Arg Gly  Ser Asn Ser Lys Leu  Ser Tyr Val 
    2285                 2290                 2295             


Leu Phe  Gly Gly Asn Glu Asp  Asn Ala Phe Thr Leu  Ser Ala Ser 
    2300                 2305                 2310             


Gly Glu  Leu Gly Val Thr Gln  Ser Leu Asp Arg Glu  Thr Lys Glu 
    2315                 2320                 2325             


Arg Phe  Val Leu Met Ile Thr  Ala Thr Asp Ser Gly  Ser Pro Ala 
    2330                 2335                 2340             


Leu Thr  Gly Thr Gly Thr Ile  Asn Val Ile Val Asp  Asp Val Asn 
    2345                 2350                 2355             


Asp Asn  Val Pro Thr Phe Ala  Ser Lys Ala Tyr Phe  Thr Thr Ile 
    2360                 2365                 2370             


Pro Glu  Asp Ala Pro Thr Gly  Thr Asp Val Leu Leu  Val Asn Ala 
    2375                 2380                 2385             


Ser Asp  Ala Asp Ala Ser Lys  Asn Ala Val Ile Ser  Tyr Arg Ile 
    2390                 2395                 2400             


Ile Gly  Gly Asn Ser Gln Phe  Thr Ile Asn Pro Ser  Thr Gly Gln 
    2405                 2410                 2415             


Ile Ile  Thr Ser Ala Leu Leu  Asp Arg Glu Thr Lys  Asp Asn Tyr 
    2420                 2425                 2430             


Thr Leu  Val Val Val Cys Ser  Asp Ala Gly Ser Pro  Glu Pro Leu 
    2435                 2440                 2445             


Ser Ser  Ser Thr Ser Val Leu  Val Thr Val Thr Asp  Val Asn Asp 
    2450                 2455                 2460             


Asn Pro  Pro Arg Phe Gln His  His Pro Tyr Val Thr  His Ile Pro 
    2465                 2470                 2475             


Ser Pro  Thr Leu Pro Gly Ser  Phe Val Phe Ala Val  Thr Val Thr 
    2480                 2485                 2490             


Asp Ala  Asp Ile Gly Pro Asn  Ser Glu Leu His Tyr  Ser Leu Ser 
    2495                 2500                 2505             


Gly Arg  Asn Ser Glu Lys Phe  His Ile Asp Pro Leu  Arg Gly Ala 
    2510                 2515                 2520             


Ile Met  Ala Ala Gly Pro Leu  Asn Gly Ala Ser Glu  Val Thr Phe 
    2525                 2530                 2535             


Ser Val  His Val Lys Asp Gly  Gly Ser Phe Pro Lys  Thr Asp Ser 
    2540                 2545                 2550             


Thr Thr  Val Thr Val Arg Phe  Val Asn Lys Ala Asp  Phe Pro Lys 
    2555                 2560                 2565             


Val Arg  Ala Lys Glu Gln Thr  Phe Met Phe Pro Glu  Asn Gln Pro 
    2570                 2575                 2580             


Val Ser  Ser Leu Val Thr Thr  Ile Thr Gly Ser Ser  Leu Arg Gly 
    2585                 2590                 2595             


Glu Pro  Met Ser Tyr Tyr Ile  Ala Ser Gly Asn Leu  Gly Asn Thr 
    2600                 2605                 2610             


Phe Gln  Ile Asp Gln Leu Thr  Gly Gln Val Ser Ile  Ser Gln Pro 
    2615                 2620                 2625             


Leu Asp  Phe Glu Lys Ile Gln  Lys Tyr Val Val Trp  Ile Glu Ala 
    2630                 2635                 2640             


Arg Asp  Gly Gly Phe Pro Pro  Phe Ser Ser Tyr Glu  Lys Leu Asp 
    2645                 2650                 2655             


Ile Thr  Val Leu Asp Val Asn  Asp Asn Ala Pro Ile  Phe Lys Glu 
    2660                 2665                 2670             


Asp Pro  Phe Ile Ser Glu Ile  Leu Glu Asn Leu Ser  Pro Arg Lys 
    2675                 2680                 2685             


Ile Leu  Thr Val Ser Ala Met  Asp Lys Asp Ser Gly  Pro Asn Gly 
    2690                 2695                 2700             


Gln Leu  Asp Tyr Glu Ile Val  Asn Gly Asn Met Glu  Asn Ser Phe 
    2705                 2710                 2715             


Ser Ile  Asn His Ala Thr Gly  Glu Ile Arg Ser Val  Arg Pro Leu 
    2720                 2725                 2730             


Asp Arg  Glu Lys Val Ser His  Tyr Val Leu Thr Ile  Lys Ser Ser 
    2735                 2740                 2745             


Asp Lys  Gly Ser Pro Ser Gln  Ser Thr Ser Val Lys  Val Met Ile 
    2750                 2755                 2760             


Asn Ile  Leu Asp Glu Asn Asp  Asn Ala Pro Arg Phe  Ser Gln Ile 
    2765                 2770                 2775             


Phe Ser  Ala His Val Pro Glu  Asn Ser Pro Leu Gly  Tyr Thr Val 
    2780                 2785                 2790             


Thr Arg  Val Thr Thr Ser Asp  Glu Asp Ile Gly Ile  Asn Ala Ile 
    2795                 2800                 2805             


Ser Arg  Tyr Ser Ile Met Asp  Ala Ser Leu Pro Phe  Thr Ile Asn 
    2810                 2815                 2820             


Pro Ser  Thr Gly Asp Ile Val  Ile Ser Arg Pro Leu  Asn Arg Glu 
    2825                 2830                 2835             


Asp Thr  Asp Arg Tyr Arg Ile  Arg Val Ser Ala His  Asp Ser Gly 
    2840                 2845                 2850             


Trp Thr  Val Ser Thr Asp Val  Thr Ile Phe Val Thr  Asp Ile Asn 
    2855                 2860                 2865             


Asp Asn  Ala Pro Arg Phe Ser  Arg Thr Ser Tyr Tyr  Leu Asp Cys 
    2870                 2875                 2880             


Pro Glu  Leu Thr Glu Ile Gly  Ser Lys Val Thr Gln  Val Phe Ala 
    2885                 2890                 2895             


Thr Asp  Pro Asp Glu Gly Ser  Asn Gly Gln Val Phe  Tyr Phe Ile 
    2900                 2905                 2910             


Lys Ser  Gln Ser Glu Tyr Phe  Arg Ile Asn Ala Thr  Thr Gly Glu 
    2915                 2920                 2925             


Ile Phe  Asn Lys Gln Ile Leu  Lys Tyr Gln Asn Val  Thr Gly Phe 
    2930                 2935                 2940             


Ser Asn  Val Asn Ile Asn Arg  His Ser Phe Ile Val  Thr Ser Ser 
    2945                 2950                 2955             


Asp Arg  Gly Lys Pro Ser Leu  Ile Ser Glu Thr Thr  Val Thr Ile 
    2960                 2965                 2970             


Asn Ile  Val Asp Ser Asn Asp  Asn Ala Pro Gln Phe  Leu Lys Ser 
    2975                 2980                 2985             


Lys Tyr  Phe Thr Pro Val Thr  Lys Asn Val Lys Val  Gly Thr Lys 
    2990                 2995                 3000             


Leu Ile  Arg Val Thr Ala Ile  Asp Asp Lys Asp Phe  Gly Leu Asn 
    3005                 3010                 3015             


Ser Glu  Val Glu Tyr Phe Ile  Ser Asn Asp Asn His  Leu Gly Lys 
    3020                 3025                 3030             


Phe Lys  Leu Asp Asn Asp Thr  Gly Trp Ile Ser Val  Ala Ser Ser 
    3035                 3040                 3045             


Leu Ile  Ser Asp Leu Asn Gln  Asn Phe Phe Ile Thr  Val Thr Ala 
    3050                 3055                 3060             


Lys Asp  Lys Gly Asn Pro Pro  Leu Ser Ser Gln Ala  Thr Val His 
    3065                 3070                 3075             


Ile Thr  Val Thr Glu Glu Asn  Tyr His Thr Pro Glu  Phe Ser Gln 
    3080                 3085                 3090             


Ser His  Met Ser Ala Thr Ile  Pro Glu Ser His Ser  Ile Gly Ser 
    3095                 3100                 3105             


Ile Val  Arg Thr Val Ser Ala  Arg Asp Arg Asp Ala  Ala Met Asn 
    3110                 3115                 3120             


Gly Leu  Ile Lys Tyr Ser Ile  Ser Ser Gly Asn Glu  Glu Gly Ile 
    3125                 3130                 3135             


Phe Ala  Ile Asn Ser Ser Thr  Gly Ile Leu Thr Leu  Ala Lys Ala 
    3140                 3145                 3150             


Leu Asp  Tyr Glu Leu Cys Gln  Lys His Glu Met Thr  Ile Ser Ala 
    3155                 3160                 3165             


Ile Asp  Gly Gly Trp Val Ala  Arg Thr Gly Tyr Cys  Ser Val Thr 
    3170                 3175                 3180             


Val Asn  Val Ile Asp Val Asn  Asp Asn Ser Pro Val  Phe Leu Ser 
    3185                 3190                 3195             


Asp Asp  Tyr Phe Pro Thr Val  Leu Glu Asn Ala Pro  Ser Gly Thr 
    3200                 3205                 3210             


Thr Val  Ile His Leu Asn Ala  Thr Asp Ala Asp Ser  Gly Thr Asn 
    3215                 3220                 3225             


Ala Val  Ile Ala Tyr Thr Val  Gln Ser Ser Asp Ser  Asp Leu Phe 
    3230                 3235                 3240             


Val Ile  Asp Pro Asn Thr Gly  Val Ile Thr Thr Gln  Gly Phe Leu 
    3245                 3250                 3255             


Asp Phe  Glu Thr Lys Gln Ser  Tyr His Leu Thr Val  Lys Ala Phe 
    3260                 3265                 3270             


Asn Val  Pro Asp Glu Glu Arg  Cys Ser Phe Ala Thr  Val Asn Ile 
    3275                 3280                 3285             


Gln Leu  Lys Gly Thr Asn Glu  Tyr Val Pro Arg Phe  Val Ser Lys 
    3290                 3295                 3300             


Leu Tyr  Tyr Phe Glu Ile Ser  Glu Ala Ala Pro Lys  Gly Thr Ile 
    3305                 3310                 3315             


Val Gly  Glu Val Phe Ala Ser  Asp Arg Asp Leu Gly  Thr Asp Gly 
    3320                 3325                 3330             


Glu Val  His Tyr Leu Ile Phe  Gly Asn Ser Arg Lys  Lys Gly Phe 
    3335                 3340                 3345             


Gln Ile  Asn Lys Lys Thr Gly  Gln Ile Tyr Val Ser  Gly Ile Leu 
    3350                 3355                 3360             


Asp Arg  Glu Lys Glu Glu Arg  Val Ser Leu Lys Val  Leu Ala Lys 
    3365                 3370                 3375             


Asn Phe  Gly Ser Ile Arg Gly  Ala Asp Ile Asp Glu  Val Thr Val 
    3380                 3385                 3390             


Asn Val  Thr Val Leu Asp Ala  Asn Asp Pro Pro Ile  Phe Thr Leu 
    3395                 3400                 3405             


Asn Ile  Tyr Ser Val Gln Ile  Ser Glu Gly Val Pro  Ile Gly Thr 
    3410                 3415                 3420             


His Val  Thr Phe Val Ser Ala  Phe Asp Ser Asp Ser  Ile Pro Ser 
    3425                 3430                 3435             


Trp Ser  Arg Phe Ser Tyr Phe  Ile Gly Ser Gly Asn  Glu Asn Gly 
    3440                 3445                 3450             


Ala Phe  Ser Ile Asn Pro Gln  Thr Gly Gln Ile Thr  Val Thr Ala 
    3455                 3460                 3465             


Glu Leu  Asp Arg Glu Thr Leu  Pro Ile Tyr Asn Leu  Ser Val Leu 
    3470                 3475                 3480             


Ala Val  Asp Ser Gly Thr Pro  Ser Ala Thr Gly Ser  Ala Ser Leu 
    3485                 3490                 3495             


Leu Val  Thr Leu Glu Asp Ile  Asn Asp Asn Gly Pro  Met Leu Thr 
    3500                 3505                 3510             


Val Ser  Glu Gly Glu Val Met  Glu Asn Lys Arg Pro  Gly Thr Leu 
    3515                 3520                 3525             


Val Met  Thr Leu Gln Ser Thr  Asp Pro Asp Leu Pro  Pro Asn Gln 
    3530                 3535                 3540             


Gly Pro  Phe Thr Tyr Tyr Leu  Leu Ser Thr Gly Pro  Ala Thr Ser 
    3545                 3550                 3555             


Tyr Phe  Ser Leu Ser Thr Ala  Gly Val Leu Ser Thr  Thr Arg Glu 
    3560                 3565                 3570             


Ile Asp  Arg Glu Gln Ile Ala  Asp Phe Tyr Leu Ser  Val Val Thr 
    3575                 3580                 3585             


Lys Asp  Ser Gly Val Pro Gln  Met Ser Ser Thr Gly  Thr Val His 
    3590                 3595                 3600             


Ile Thr  Val Ile Asp Gln Asn  Asp Asn Pro Ser Gln  Ser Arg Thr 
    3605                 3610                 3615             


Val Glu  Ile Phe Val Asn Tyr  Tyr Gly Asn Leu Phe  Pro Gly Gly 
    3620                 3625                 3630             


Ile Leu  Gly Ser Val Lys Pro  Gln Asp Pro Asp Val  Leu Asp Ser 
    3635                 3640                 3645             


Phe His  Cys Ser Leu Thr Ser  Gly Val Thr Ser Leu  Phe Ser Ile 
    3650                 3655                 3660             


Pro Gly  Gly Thr Cys Asp Leu  Asn Ser Gln Pro Arg  Ser Thr Asp 
    3665                 3670                 3675             


Gly Thr  Phe Asp Leu Thr Val  Leu Ser Asn Asp Gly  Val His Ser 
    3680                 3685                 3690             


Thr Val  Thr Ser Asn Ile Arg  Val Phe Phe Ala Gly  Phe Ser Asn 
    3695                 3700                 3705             


Ala Thr  Val Asp Asn Ser Ile  Leu Leu Arg Leu Gly  Val Pro Thr 
    3710                 3715                 3720             


Val Lys  Asp Phe Leu Thr Asn  His Tyr Leu His Phe  Leu Arg Ile 
    3725                 3730                 3735             


Ala Ser  Ser Gln Leu Thr Gly  Leu Gly Thr Ala Val  Gln Leu Tyr 
    3740                 3745                 3750             


Ser Ala  Tyr Glu Glu Asn Asn  Arg Thr Phe Leu Leu  Ala Ala Val 
    3755                 3760                 3765             


Lys Arg  Asn His Asn Gln Tyr  Val Asn Pro Ser Gly  Val Ala Thr 
    3770                 3775                 3780             


Phe Phe  Glu Ser Ile Lys Glu  Ile Leu Leu Arg Gln  Ser Gly Val 
    3785                 3790                 3795             


Lys Val  Glu Ser Val Asp His  Asp Ser Cys Val His  Gly Pro Cys 
    3800                 3805                 3810             


Gln Asn  Gly Gly Ser Cys Leu  Arg Arg Leu Ala Val  Ser Ser Val 
    3815                 3820                 3825             


Leu Lys  Ser Arg Glu Ser Leu  Pro Val Ile Ile Val  Ala Asn Glu 
    3830                 3835                 3840             


Pro Leu  Gln Pro Phe Leu Cys  Lys Cys Leu Pro Gly  Tyr Ala Gly 
    3845                 3850                 3855             


Ser Trp  Cys Glu Ile Asp Ile  Asp Glu Cys Leu Pro  Ser Pro Cys 
    3860                 3865                 3870             


His Ser  Gly Gly Thr Cys His  Asn Leu Val Gly Gly  Phe Ser Cys 
    3875                 3880                 3885             


Ser Cys  Pro Asp Gly Phe Thr  Gly Arg Ala Cys Glu  Arg Asp Ile 
    3890                 3895                 3900             


Asn Glu  Cys Leu Gln Ser Pro  Cys Lys Asn Gly Ala  Ile Cys Gln 
    3905                 3910                 3915             


Asn Phe  Pro Gly Ser Phe Asn  Cys Val Cys Lys Thr  Gly Tyr Thr 
    3920                 3925                 3930             


Gly Lys  Met Cys Glu Ser Ser  Val Asn Tyr Cys Glu  Cys Asn Pro 
    3935                 3940                 3945             


Cys Phe  Asn Gly Gly Ser Cys  Gln Ser Gly Val Asp  Ser Tyr Tyr 
    3950                 3955                 3960             


Cys His  Cys Pro Phe Gly Val  Phe Gly Lys His Cys  Glu Leu Asn 
    3965                 3970                 3975             


Ser Tyr  Gly Phe Glu Glu Leu  Ser Tyr Met Glu Phe  Pro Ser Leu 
    3980                 3985                 3990             


Asp Pro  Asn Asn Asn Tyr Ile  Tyr Val Lys Phe Ala  Thr Ile Lys 
    3995                 4000                 4005             


Ser His  Ala Leu Leu Leu Tyr  Asn Tyr Asp Asn Gln  Thr Gly Asp 
    4010                 4015                 4020             


Arg Ala  Glu Phe Leu Ala Leu  Glu Ile Ala Glu Glu  Arg Leu Arg 
    4025                 4030                 4035             


Phe Ser  Tyr Asn Leu Gly Ser  Gly Thr Tyr Lys Leu  Thr Thr Met 
    4040                 4045                 4050             


Lys Lys  Val Ser Asp Gly His  Phe His Thr Val Ile  Ala Arg Arg 
    4055                 4060                 4065             


Ala Gly  Met Ala Ala Ser Leu  Thr Val Asp Ser Cys  Ser Glu Asn 
    4070                 4075                 4080             


Gln Glu  Pro Gly Tyr Cys Thr  Val Ser Asn Val Ala  Val Ser Asp 
    4085                 4090                 4095             


Asp Trp  Thr Leu Asp Val Gln  Pro Asn Arg Val Thr  Val Gly Gly 
    4100                 4105                 4110             


Ile Arg  Ser Leu Glu Pro Ile  Leu Gln Arg Arg Gly  His Val Glu 
    4115                 4120                 4125             


Ser His  Asp Phe Val Gly Cys  Ile Met Glu Phe Ala  Val Asn Gly 
    4130                 4135                 4140             


Arg Pro  Leu Glu Pro Ser Gln  Ala Leu Ala Ala Gln  Gly Ile Leu 
    4145                 4150                 4155             


Asp Gln  Cys Pro Arg Leu Glu  Gly Ala Cys Thr Arg  Ser Pro Cys 
    4160                 4165                 4170             


Gln His  Gly Gly Thr Cys Met  Asp Tyr Trp Ser Trp  Gln Gln Cys 
    4175                 4180                 4185             


His Cys  Lys Glu Gly Leu Thr  Gly Lys Tyr Cys Glu  Lys Ser Val 
    4190                 4195                 4200             


Thr Pro  Asp Thr Ala Leu Ser  Leu Glu Gly Lys Gly  Arg Leu Asp 
    4205                 4210                 4215             


Tyr His  Met Ser Gln Asn Glu  Lys Arg Glu Tyr Leu  Leu Arg Gln 
    4220                 4225                 4230             


Ser Leu  Arg Gly Ala Met Leu  Glu Pro Phe Gly Val  Asn Ser Leu 
    4235                 4240                 4245             


Glu Val  Lys Phe Arg Thr Arg  Ser Glu Asn Gly Val  Leu Ile His 
    4250                 4255                 4260             


Ile Gln  Glu Ser Ser Asn Tyr  Thr Thr Val Lys Ile  Lys Asn Gly 
    4265                 4270                 4275             


Lys Val  Tyr Phe Thr Ser Asp  Ala Gly Ile Ala Gly  Lys Val Glu 
    4280                 4285                 4290             


Arg Asn  Ile Pro Glu Val Tyr  Val Ala Asp Gly His  Trp His Thr 
    4295                 4300                 4305             


Phe Leu  Ile Gly Lys Asn Gly  Thr Ala Thr Val Leu  Ser Val Asp 
    4310                 4315                 4320             


Arg Ile  Tyr Asn Arg Asp Ile  Ile His Pro Thr Gln  Asp Phe Gly 
    4325                 4330                 4335             


Gly Leu  Asp Val Leu Thr Ile  Ser Leu Gly Gly Ile  Pro Pro Asn 
    4340                 4345                 4350             


Gln Ala  His Arg Asp Ala Gln  Thr Ala Gly Phe Asp  Gly Cys Ile 
    4355                 4360                 4365             


Ala Ser  Met Trp Tyr Gly Gly  Glu Ser Leu Pro Phe  Ser Gly Lys 
    4370                 4375                 4380             


His Ser  Leu Ala Ser Ile Ser  Lys Thr Asp Pro Ser  Val Lys Ile 
    4385                 4390                 4395             


Gly Cys  Arg Gly Pro Asn Ile  Cys Ala Ser Asn Pro  Cys Trp Gly 
    4400                 4405                 4410             


Asp Leu  Leu Cys Ile Asn Gln  Trp Tyr Ala Tyr Arg  Cys Val Pro 
    4415                 4420                 4425             


Pro Gly  Asp Cys Ala Ser His  Pro Cys Gln Asn Gly  Gly Ser Cys 
    4430                 4435                 4440             


Glu Pro  Gly Leu His Ser Gly  Phe Thr Cys Ser Cys  Pro Asp Ser 
    4445                 4450                 4455             


His Thr  Gly Arg Thr Cys Glu  Met Val Val Ala Cys  Leu Gly Val 
    4460                 4465                 4470             


Leu Cys  Pro Gln Gly Lys Val  Cys Lys Ala Gly Ser  Pro Ala Gly 
    4475                 4480                 4485             


His Val  Cys Val Leu Ser Gln  Gly Pro Glu Glu Ile  Ser Leu Pro 
    4490                 4495                 4500             


Leu Trp  Ala Val Pro Ala Ile  Val Gly Ser Cys Ala  Thr Val Leu 
    4505                 4510                 4515             


Ala Leu  Leu Val Leu Ser Leu  Ile Leu Cys Asn Gln  Cys Arg Gly 
    4520                 4525                 4530             


Lys Lys  Ala Lys Asn Pro Lys  Glu Glu Lys Lys Pro  Lys Glu Lys 
    4535                 4540                 4545             


Lys Lys  Lys Gly Ser Glu Asn  Val Ala Phe Asp Asp  Pro Asp Asn 
    4550                 4555                 4560             


Ile Pro  Pro Tyr Gly Asp Asp  Met Thr Val Arg Lys  Gln Pro Glu 
    4565                 4570                 4575             


Gly Asn  Pro Lys Pro Asp Ile  Ile Glu Arg Glu Asn  Pro Tyr Leu 
    4580                 4585                 4590             


Ile Tyr  Asp Glu Thr Asp Ile  Pro His Asn Ser Glu  Thr Ile Pro 
    4595                 4600                 4605             


Ser Ala  Pro Leu Ala Ser Pro  Glu Gln Glu Ile Glu  His Tyr Asp 
    4610                 4615                 4620             


Ile Asp  Asn Ala Ser Ser Ile  Ala Pro Ser Asp Ala  Asp Ile Ile 
    4625                 4630                 4635             


Gln His  Tyr Lys Gln Phe Arg  Ser His Thr Pro Lys  Phe Ser Ile 
    4640                 4645                 4650             


Gln Arg  His Ser Pro Leu Gly  Phe Ala Arg Gln Ser  Pro Met Pro 
    4655                 4660                 4665             


Leu Gly  Ala Ser Ser Leu Thr  Tyr Gln Pro Ser Tyr  Gly Gln Gly 
    4670                 4675                 4680             


Leu Arg  Thr Ser Ser Leu Ser  His Ser Ala Cys Pro  Thr Pro Asn 
    4685                 4690                 4695             


Pro Leu  Ser Arg His Ser Pro  Ala Pro Phe Ser Lys  Ser Ser Thr 
    4700                 4705                 4710             


Phe Tyr  Arg Asn Ser Pro Ala  Arg Glu Leu His Leu  Pro Ile Arg 
    4715                 4720                 4725             


Asp Gly  Asn Thr Leu Glu Met  His Gly Asp Thr Cys  Gln Pro Gly 
    4730                 4735                 4740             


Ile Phe  Asn Tyr Ala Thr Arg  Leu Gly Arg Arg Ser  Lys Ser Pro 
    4745                 4750                 4755             


Gln Ala  Met Ala Ser His Gly  Ser Arg Pro Gly Ser  Arg Leu Lys 
    4760                 4765                 4770             


Gln Pro  Ile Gly Gln Ile Pro  Leu Glu Ser Ser Pro  Pro Val Gly 
    4775                 4780                 4785             


Leu Ser  Ile Glu Glu Val Glu  Arg Leu Asn Thr Pro  Arg Pro Arg 
    4790                 4795                 4800             


Asn Pro  Ser Ile Cys Ser Ala  Asp His Gly Arg Ser  Ser Ser Glu 
    4805                 4810                 4815             


Glu Asp  Cys Arg Arg Pro Leu  Ser Arg Thr Arg Asn  Pro Ala Asp 
    4820                 4825                 4830             


Gly Ile  Pro Ala Pro Glu Ser  Ser Ser Asp Ser Asp  Ser His Glu 
    4835                 4840                 4845             


Ser Phe  Thr Cys Ser Glu Met  Glu Tyr Asp Arg Glu  Lys Pro Met 
    4850                 4855                 4860             


Val Tyr  Thr Ser Arg Met Pro  Lys Leu Ser Gln Val  Asn Glu Ser 
    4865                 4870                 4875             


Asp Ala  Asp Asp Glu Asp Asn  Tyr Gly Ala Arg Leu  Lys Pro Arg 
    4880                 4885                 4890             


Arg Tyr  His Gly Arg Arg Ala  Glu Gly Gly Pro Val  Gly Thr Gln 
    4895                 4900                 4905             


Ala Ala  Ala Pro Gly Thr Ala  Asp Asn Thr Leu Pro  Met Lys Leu 
    4910                 4915                 4920             


Gly Gln  Gln Ala Gly Thr Phe  Asn Trp Asp Asn Leu  Leu Asn Trp 
    4925                 4930                 4935             


Gly Pro  Gly Phe Gly His Tyr  Val Asp Val Phe Lys  Asp Leu Ala 
    4940                 4945                 4950             


Ser Leu  Pro Glu Lys Ala Ala  Ala Asn Glu Glu Gly  Lys Ala Gly 
    4955                 4960                 4965             


Thr Thr  Lys Pro Val Pro Lys  Asp Gly Glu Ala Glu  Gln Tyr Val 
    4970                 4975                 4980             


<210>  6
<211>  4979
<212>  PRT
<213>  rattus norvegicus


<220>
<221>  MISC_FEATURE
<223>  rat Fat 4 polypeptide

<400>  6

Met Asn Leu Ala Ala Asn Arg Thr Pro Gly Arg Arg Arg Phe Pro Leu 
1               5                   10                  15      


Pro Ser Pro Ser Leu Gly Gln Leu Leu Arg Val Trp Gly Leu Leu Ser 
            20                  25                  30          


Leu Leu Pro Ser Pro Ala Arg Val Gln Ala Ala Glu Gln Arg Gln Val 
        35                  40                  45              


Phe Gln Val Met Glu Glu Gln Pro Pro Gly Thr Leu Val Gly Thr Ile 
    50                  55                  60                  


Pro Thr Arg Pro Gly Phe Thr Tyr Arg Leu Ser Glu Ser His Ala Leu 
65                  70                  75                  80  


Phe Ala Ile Asn Ser Ser Thr Gly Ala Leu Tyr Thr Thr Ala Thr Ile 
                85                  90                  95      


Asp Arg Glu Ser Leu Pro Ser Asp Val Val Asn Leu Val Val Leu Ser 
            100                 105                 110         


Ser Ser Pro Thr Tyr Pro Thr Glu Val Arg Val Leu Val Arg Asp Leu 
        115                 120                 125             


Asn Asp Asn Ala Pro Val Phe Pro Asp Pro Ser Ile Val Val Thr Phe 
    130                 135                 140                 


Lys Glu Asp Ser Gly Ser Gly Arg Gln Val Ile Leu Asp Thr Ala Thr 
145                 150                 155                 160 


Asp Ser Asp Ile Gly Ser Asn Gly Val Asp His Arg Ser Tyr Arg Ile 
                165                 170                 175     


Val Arg Gly Asn Glu Ala Gly Arg Phe Arg Leu Asp Ile Thr Leu Asn 
            180                 185                 190         


Pro Ser Gly Glu Gly Ala Phe Leu His Leu Val Ser Lys Gly Gly Leu 
        195                 200                 205             


Asp Arg Glu Val Thr Pro Gln Tyr Gln Leu Leu Val Glu Val Glu Asp 
    210                 215                 220                 


Lys Gly Glu Pro Lys Arg Arg Gly Tyr Leu Gln Val Asn Val Thr Val 
225                 230                 235                 240 


Gln Asp Ile Asn Asp Asn Pro Pro Val Phe Gly Ser Ser His Tyr Gln 
                245                 250                 255     


Ala Gly Val Pro Glu Asp Ala Val Val Gly Ser Ser Val Leu Gln Val 
            260                 265                 270         


Ala Ala Ala Asp Ala Asp Glu Gly Thr Asn Ala Asp Ile Arg Tyr Arg 
        275                 280                 285             


Leu Gln Asp Glu Gly Thr Pro Phe Gln Met Asp Pro Glu Thr Gly Leu 
    290                 295                 300                 


Ile Thr Val Arg Glu Pro Leu Asp Phe Glu Ala Arg Arg Gln Tyr Ser 
305                 310                 315                 320 


Leu Thr Val Gln Ala Thr Asp Arg Gly Val Pro Ser Leu Thr Gly Arg 
                325                 330                 335     


Ala Glu Ala Leu Ile Gln Leu Leu Asp Val Asn Asp Asn Asp Pro Val 
            340                 345                 350         


Val Lys Phe Arg Tyr Phe Pro Ala Thr Ser Arg Tyr Ala Ser Val Asp 
        355                 360                 365             


Glu Asn Ala Gln Val Gly Thr Val Val Ala Leu Leu Thr Val Thr Asp 
    370                 375                 380                 


Ala Asp Ser Pro Ala Ala Asn Gly Asn Ile Ser Val Gln Ile Leu Gly 
385                 390                 395                 400 


Gly Asn Glu Gln Arg His Phe Glu Val Gln Arg Ser Lys Val Pro Asn 
                405                 410                 415     


Leu Ser Leu Ile Lys Val Ala Ser Ala Leu Asp Arg Glu Arg Ile Pro 
            420                 425                 430         


Ser Tyr Asn Leu Thr Val Ser Val Ser Asp Asn Ser Gly Ala Pro Pro 
        435                 440                 445             


Thr Ala Glu Val Gln Ala Arg Ser Ser Val Ala Ser Leu Val Ile Phe 
    450                 455                 460                 


Val Asn Asp Ile Asn Asp His Pro Pro Val Phe Glu Gln Gln Val Tyr 
465                 470                 475                 480 


Arg Val Asn Leu Ser Glu Glu Val Pro Pro Gly Ser Tyr Val Ser Gly 
                485                 490                 495     


Val Ser Ala Thr Asp Gly Asp Ser Gly Leu Asn Ala Asn Leu Arg Tyr 
            500                 505                 510         


Ser Ile Val Ser Gly Asn Gly Leu Gly Trp Phe His Ile Ser Glu His 
        515                 520                 525             


Ser Gly Leu Val Thr Thr Ser Ala Ala Gly Gly Leu Asp Arg Glu Leu 
    530                 535                 540                 


Ala Ser Gln Ile Val Leu Asn Ile Ser Ala Arg Asp Gln Gly Val His 
545                 550                 555                 560 


Pro Lys Val Ser Tyr Ala Gln Leu Val Val Ser Val Leu Asp Val Asn 
                565                 570                 575     


Asp Gln Lys Pro Val Phe Ser Gln Pro Glu Gly Tyr Glu Val Ser Val 
            580                 585                 590         


Val Glu Asn Ala Pro Thr Gly Thr Glu Leu Leu Val Leu Gly Ala Thr 
        595                 600                 605             


Asp Gly Asp Leu Gly Asp Asn Gly Thr Val Arg Phe Ser Leu Gln Glu 
    610                 615                 620                 


Ala Glu Ser Asp Gln Arg Leu Phe Arg Leu Asp Pro Val Ser Gly Arg 
625                 630                 635                 640 


Leu Ser Thr Ile Ser Ser Leu Asp Arg Glu Glu Gln Ala Phe Tyr Cys 
                645                 650                 655     


Leu Leu Ile Leu Ala Thr Asp Leu Gly Ser Pro Pro Gln Ser Ser Thr 
            660                 665                 670         


Val Gln Val Asn Val Ser Leu Leu Asp Ile Asn Asp Asn Ser Pro Val 
        675                 680                 685             


Phe Tyr Pro Val Gln Tyr Phe Ala His Ile Gln Glu Asn Glu Pro Gly 
    690                 695                 700                 


Gly Ser Tyr Val Thr Thr Val Ser Ala Thr Asp Pro Asp Met Gly Pro 
705                 710                 715                 720 


Asn Gly Thr Val Lys Tyr Ser Ile Ser Ala Gly Asp Arg Ser Arg Phe 
                725                 730                 735     


Gln Ile His Ala Lys Ser Gly Val Ile Ser Thr Lys Met Ala Leu Asp 
            740                 745                 750         


Arg Glu Glu Lys Thr Ala Tyr Gln Leu Gln Ile Val Ala Thr Asp Gly 
        755                 760                 765             


Gly Asn Leu Gln Ser Pro Ser Gln Ala Ile Val Thr Val Thr Val Leu 
    770                 775                 780                 


Asp Thr Gln Asp Asn Pro Pro Val Phe Ser Gln Ala Ala Tyr Ser Phe 
785                 790                 795                 800 


Val Val Phe Glu Asn Val Ala Leu Gly Tyr His Val Gly Ser Val Ser 
                805                 810                 815     


Ala Thr Thr Met Asp Leu Asn Ala Asn Ile Ser Tyr Leu Ile Thr Thr 
            820                 825                 830         


Gly Asp Gln Arg Gly Met Phe Ala Met Asn Pro Val Thr Gly Gln Leu 
        835                 840                 845             


Thr Thr Ala Ser Val Ile Asp Arg Glu Glu Gln Ser Phe Tyr Gln Leu 
    850                 855                 860                 


Arg Val Val Ala Ser Gly Gly Ala Val Thr Gly Asp Ala Val Val Asn 
865                 870                 875                 880 


Ile Thr Val Lys Asp Leu Asn Asp Asn Ala Pro His Phe Leu Gln Ala 
                885                 890                 895     


Val Glu Ser Ile Asp Ala Val Glu Asn Trp Gln Ala Gly His Ser Ile 
            900                 905                 910         


Phe Gln Ala Lys Ala Val Asp Pro Asp Glu Gly Val Asn Gly Arg Val 
        915                 920                 925             


Leu Tyr Ser Leu Lys Gln Asn Pro Lys Asn Leu Phe Thr Ile Asn Glu 
    930                 935                 940                 


Gln Asn Gly Asn Ile Ser Leu Leu Gly Thr Leu Asp Val His Ala Gly 
945                 950                 955                 960 


Ser Tyr Gln Val Glu Ile Val Ala Ser Asp Met Gly Val Pro Gln Leu 
                965                 970                 975     


Ser Ser Ser Ile Ile Leu Thr Val Tyr Val His Asp Val Asn Asp Asn 
            980                 985                 990         


Pro Pro Val Phe Asp Gln Ile Ser  Tyr Glu Val Thr Leu  Ser Glu Ser 
        995                 1000                 1005             


Glu Pro  Val Asn Ser Arg Phe  Phe Lys Val Gln Ala  Leu Asp Lys 
    1010                 1015                 1020             


Asp Ser  Gly Ala Asn Gly Glu  Ile Ala Tyr Ala Ile  Thr Asp Gly 
    1025                 1030                 1035             


Asn Ser  Gly Glu Ala Phe Gly  Ile Phe Pro Asp Gly  Gln Leu Tyr 
    1040                 1045                 1050             


Ile Lys  Ser Glu Leu Asp Arg  Glu Leu Gln Asp Arg  Tyr Val Leu 
    1055                 1060                 1065             


Leu Val  Val Ala Ser Asp Arg  Ala Val Glu Pro Leu  Ser Ala Thr 
    1070                 1075                 1080             


Val Asn  Val Thr Val Ile Leu  Glu Asp Val Asn Asp  Asn Arg Pro 
    1085                 1090                 1095             


Leu Phe  Asn Ser Thr Asn Tyr  Thr Phe Tyr Phe Glu  Glu Glu Gln 
    1100                 1105                 1110             


Arg Ala  Gly Ser Phe Val Gly  Lys Val Ser Ala Val  Asp Lys Asp 
    1115                 1120                 1125             


Phe Gly  Pro Asn Gly Glu Val  Arg Tyr Ala Phe Glu  Val Ala Gln 
    1130                 1135                 1140             


Pro Asp  Phe Glu Leu His Ala  Ile Thr Gly Glu Ile  Thr Asn Thr 
    1145                 1150                 1155             


His Lys  Phe Asp Arg Glu Ser  Leu Met Arg Arg Arg  Gly Thr Ala 
    1160                 1165                 1170             


Val Phe  Ser Phe Thr Val Ile  Ala Thr Asp Gln Gly  Leu Pro Gln 
    1175                 1180                 1185             


Pro Leu  Lys Asp Gln Ala Thr  Val His Val Tyr Met  Lys Asp Ile 
    1190                 1195                 1200             


Asn Asp  Asn Ala Pro Lys Phe  Leu Lys Asp Phe Tyr  Gln Ala Thr 
    1205                 1210                 1215             


Val Ser  Glu Thr Ala Thr Asn  Leu Thr Gln Val Leu  Arg Val Ser 
    1220                 1225                 1230             


Ala Ser  Asp Val Asp Glu Gly  Asn Asn Gly Leu Ile  His Tyr Ser 
    1235                 1240                 1245             


Ile Leu  Lys Gly Asn Glu Glu  Arg Gln Phe Ser Ile  Asp Arg Phe 
    1250                 1255                 1260             


Ser Gly  Gln Val Thr Leu Val  Gly Lys Leu Asp Tyr  Glu Ala Thr 
    1265                 1270                 1275             


Pro Ala  Tyr Ser Leu Leu Ile  Gln Ala Val Asp Ser  Gly Thr Val 
    1280                 1285                 1290             


Pro Leu  Asn Ser Thr Cys Thr  Leu Ser Ile Asp Ile  Leu Asp Glu 
    1295                 1300                 1305             


Asn Asp  Asn Thr Pro Ser Phe  Pro Lys Ser Thr Leu  Phe Val Asp 
    1310                 1315                 1320             


Val Leu  Glu Asn Met Arg Ile  Gly Glu Leu Val Ser  Ser Val Thr 
    1325                 1330                 1335             


Ala Thr  Asp Ser Asp Ser Gly  Val Asn Ala Asp Leu  His Tyr Thr 
    1340                 1345                 1350             


Ile Thr  Gly Ser Asn Asn His  Gly Thr Phe Ser Ile  Ser Pro Asn 
    1355                 1360                 1365             


Thr Gly  Ser Ile Phe Leu Ala  Lys Lys Leu Asp Phe  Glu Thr Gln 
    1370                 1375                 1380             


Ser Leu  Tyr Lys Leu Asn Ile  Thr Ala Lys Asp Gln  Gly Arg Pro 
    1385                 1390                 1395             


Pro Arg  Ser Ser Thr Met Ser  Val Val Ile His Val  Arg Asp Phe 
    1400                 1405                 1410             


Asn Asp  Asn Pro Pro Ser Phe  Pro Pro Gly Asp Ile  Phe Lys Ser 
    1415                 1420                 1425             


Ile Val  Glu Asn Ile Pro Leu  Gly Thr Ser Val Ile  Ser Val Thr 
    1430                 1435                 1440             


Ala His  Asp Pro Asp Ala Asp  Ile Asn Gly Gln Leu  Ser Tyr Ala 
    1445                 1450                 1455             


Ile Ile  Gln Gln Met Pro Arg  Gly Asn His Phe Ser  Ile Asp Glu 
    1460                 1465                 1470             


Val Lys  Gly Thr Ile Tyr Thr  Ser Ala Glu Ile Asp  Arg Glu Phe 
    1475                 1480                 1485             


Ala Asn  Leu Phe Glu Leu Thr  Val Lys Ala Asn Asp  Gln Ala Val 
    1490                 1495                 1500             


Pro Ile  Glu Thr Arg Arg Tyr  Ala Leu Lys Asn Val  Thr Ile Leu 
    1505                 1510                 1515             


Val Thr  Asp Leu Asn Asp Asn  Val Pro Ile Phe Ile  Ser Gln Asn 
    1520                 1525                 1530             


Ala Leu  Ala Ala Asp Pro Ser  Ala Met Ile Gly Ser  Val Leu Thr 
    1535                 1540                 1545             


Thr Ile  Met Ala Ala Asp Pro  Asp Glu Gly Ala Asn  Gly Glu Val 
    1550                 1555                 1560             


Glu Tyr  Glu Ile Val Asn Gly  Asp Thr Asp Thr Phe  Thr Val Asp 
    1565                 1570                 1575             


Arg Tyr  Ser Gly Asp Leu Arg  Val Ala Ser Ala Leu  Val Pro Ser 
    1580                 1585                 1590             


Gln Leu  Ile Tyr Asn Leu Ile  Val Ser Ala Thr Asp  Leu Gly Pro 
    1595                 1600                 1605             


Glu Arg  Arg Lys Ser Thr Thr  Glu Leu Thr Val Ile  Leu Gln Gly 
    1610                 1615                 1620             


Leu Asp  Gly Pro Val Phe Thr  Gln Thr Lys Tyr Ile  Thr Ile Leu 
    1625                 1630                 1635             


Lys Glu  Gly Glu Pro Ile Gly  Thr Asn Val Ile Ser  Ile Glu Ala 
    1640                 1645                 1650             


Ala Ser  Pro Arg Gly Ser Glu  Ala Pro Val Glu Tyr  Tyr Ile Val 
    1655                 1660                 1665             


Ser Val  Arg Cys Glu Glu Lys  Thr Val Gly Arg Leu  Phe Thr Ile 
    1670                 1675                 1680             


Gly Arg  Gln Thr Gly Val Ile  Gln Thr Ala Ala Ile  Leu Asp Arg 
    1685                 1690                 1695             


Glu Gln  Gly Ala Cys Leu Tyr  Leu Val Asp Val Tyr  Ala Ile Glu 
    1700                 1705                 1710             


Lys Ser  Ser Ala Phe Pro Arg  Thr Gln Arg Ala Glu  Val Glu Ile 
    1715                 1720                 1725             


Thr Leu  Gln Asp Ile Asn Asp  Asn Pro Pro Val Phe  Pro Thr Asp 
    1730                 1735                 1740             


Thr Leu  Asp Leu Thr Val Glu  Glu Asn Ile Gly Asp  Gly Ser Lys 
    1745                 1750                 1755             


Ile Met  Gln Leu Thr Ala Met  Asp Ala Asp Glu Gly  Ala Asn Ala 
    1760                 1765                 1770             


Leu Val  Thr Tyr Ala Leu Ile  Ser Gly Ala Asp Asp  Ser Phe Arg 
    1775                 1780                 1785             


Ile Asp  Pro Glu Ser Gly Asp  Leu Ile Ala Thr Lys  Arg Leu Asp 
    1790                 1795                 1800             


Arg Glu  His Arg Ser Lys Tyr  Ser Leu Leu Val Arg  Ala Asp Asp 
    1805                 1810                 1815             


Gly Leu  Gln Ser Ser Asp Met  Arg Ile Asn Ile Thr  Ile Ser Asp 
    1820                 1825                 1830             


Val Asn  Asp His Thr Pro Arg  Phe Ser Arg Pro Val  Tyr Ser Phe 
    1835                 1840                 1845             


Asp Ile  Pro Glu Asp Thr Thr  Pro Gly Ser Leu Val  Ala Ala Ile 
    1850                 1855                 1860             


Leu Ala  Thr Asp Asp Asp Ser  Gly Val Asn Gly Glu  Ile Ser Tyr 
    1865                 1870                 1875             


Val Val  Glu Glu Asp Asp Gly  Asp Gly Val Phe Phe  Leu Asn Pro 
    1880                 1885                 1890             


Val Thr  Gly Val Phe Asn Leu  Thr Arg Ala Leu Asp  Tyr Glu Arg 
    1895                 1900                 1905             


Gln Gln  Tyr Tyr Ile Leu Thr  Val Arg Ala Glu Asp  Gly Gly Gly 
    1910                 1915                 1920             


Gln Phe  Thr Thr Ile Arg Ala  Tyr Phe Asn Ile Leu  Asp Ile Asn 
    1925                 1930                 1935             


Asp Asn  Pro Pro Val Phe Ser  Leu Ser Ser Tyr Ser  Thr Ser Leu 
    1940                 1945                 1950             


Met Glu  Asn Leu Pro Leu Gly  Ser Thr Val Leu Val  Phe Asn Val 
    1955                 1960                 1965             


Thr Asp  Ala Asp Asp Gly Val  Asn Ser Gln Leu Ser  Tyr Ser Ile 
    1970                 1975                 1980             


Ala Ser  Gly Asp Ser Leu Gly  Gln Phe Ala Val Asp  Lys His Gly 
    1985                 1990                 1995             


Val Leu  Lys Ala Leu Lys Ala  Leu Asp Arg Glu Ser  Gln Ser Phe 
    2000                 2005                 2010             


Tyr Asn  Leu Val Ile Gln Val  His Asp Leu Pro Gln  Pro Pro Ala 
    2015                 2020                 2025             


Ser Arg  Phe Thr Ser Thr Ala  Gln Val Ser Ile Ile  Leu Leu Asp 
    2030                 2035                 2040             


Val Asn  Asp Asn Pro Pro Met  Phe Leu Ser Pro Lys  Leu Thr Tyr 
    2045                 2050                 2055             


Ile Pro  Glu Asn Thr Pro Ile  Asp Thr Val Val Phe  Lys Ala Gln 
    2060                 2065                 2070             


Ala Thr  Asp Pro Asp Ser Gly  Pro Asn Ser Tyr Ile  Glu Tyr Thr 
    2075                 2080                 2085             


Leu Leu  Asn Pro Ala Gly Asn  Lys Phe Ser Ile Gly  Thr Ile Asp 
    2090                 2095                 2100             


Gly Glu  Val His Leu Thr Gly  Glu Leu Asp Arg Glu  Glu Val Ser 
    2105                 2110                 2115             


Asn Tyr  Ser Leu Thr Val Val  Ala Thr Asp Lys Gly  Gln Pro Pro 
    2120                 2125                 2130             


Leu Ser  Ser Ser Thr Glu Val  Val Val Met Val Leu  Asp Ile Asn 
    2135                 2140                 2145             


Asp Asn  Asn Pro Val Phe Ala  Gln Ala Met Tyr Arg  Val Gln Ile 
    2150                 2155                 2160             


Lys Glu  Asn Thr Leu Thr Gly  Thr Asp Ile Ile Gln  Val Ser Ala 
    2165                 2170                 2175             


Ala Asp  Asn Asp Glu Gly Thr  Asn Gly Gln Val Arg  Tyr Gly Ile 
    2180                 2185                 2190             


Val Gly  Gly Asn Thr His Gln  Glu Phe Arg Ile Asp  Ser Val Thr 
    2195                 2200                 2205             


Gly Ala  Ile Thr Val Ala Lys  Ser Leu Asp Arg Glu  Thr Ile Pro 
    2210                 2215                 2220             


Ala Tyr  Ile Leu Thr Val Gln  Ala Thr Asp Arg Gly  Ser Ser Pro 
    2225                 2230                 2235             


Arg Thr  Asp Ser Cys Thr Val  Ala Ile Thr Leu Leu  Asp Met Asn 
    2240                 2245                 2250             


Asp Phe  Val Pro Val Phe Glu  Leu Ser Pro Tyr Ser  Val Asn Val 
    2255                 2260                 2265             


Pro Glu  Asn Leu Gly Ala Leu  Pro Arg Thr Ile Leu  Gln Val Val 
    2270                 2275                 2280             


Ala Arg  Asp Asp Asp Gln Gly  Pro Asn Ser Gln Leu  Ser Tyr Val 
    2285                 2290                 2295             


Leu Leu  Gly Gly Asn Glu Asp  Asn Ala Phe Ala Leu  Thr Ala Ser 
    2300                 2305                 2310             


Gly Glu  Leu Arg Val Thr Gln  Ser Leu Asp Arg Glu  Ala Arg Asp 
    2315                 2320                 2325             


His Phe  Val Leu Val Val Thr  Ala Ala Asp Ala Gly  Ser Pro Ala 
    2330                 2335                 2340             


Leu Thr  Gly Thr Gly Thr Ile  Asn Ile Ile Val Asp  Asp Ile Asn 
    2345                 2350                 2355             


Asp Asn  Val Pro Thr Phe Ala  Ser Asn Met Tyr Phe  Thr Ala Ile 
    2360                 2365                 2370             


Pro Glu  Asp Ala Pro Thr Gly  Thr Asp Val Leu Leu  Val Asn Ala 
    2375                 2380                 2385             


Ser Asp  Ala Asp Ala Ala Thr  Asn Ala Val Ile Ser  Ile Ile Gly 
    2390                 2395                 2400             


Gly Asn  Ser Gln Phe Thr Ile  Asn Pro Ser Thr Gly  Gln Ile Ile 
    2405                 2410                 2415             


Thr Ser  Ala Leu Leu Asp Arg  Glu Thr Lys Asp Asn  Tyr Thr Leu 
    2420                 2425                 2430             


Val Val  Val Ala Ser Asp Ala  Gly Ser Pro Glu Ser  Leu Ser Ser 
    2435                 2440                 2445             


Ser Thr  Ser Val Leu Val Ser  Val Thr Asp Val Asn  Asp Asn Pro 
    2450                 2455                 2460             


Pro Arg  Phe Gln His His Pro  Tyr Val Thr His Ile  Pro Ser Pro 
    2465                 2470                 2475             


Thr Pro  Pro Gly Ser Phe Val  Phe Ala Val Thr Val  Thr Asp Ala 
    2480                 2485                 2490             


Asp Ile  Gly Pro Asn Ser Glu  Leu His Tyr Ser Leu  Ser Gly Arg 
    2495                 2500                 2505             


Asn Ser  Glu Lys Phe His Ile  Asp Pro Leu Arg Gly  Ala Ile Met 
    2510                 2515                 2520             


Ala Ala  Gly Pro Leu Ser Gly  Ala Ser Glu Val Thr  Phe Ser Val 
    2525                 2530                 2535             


His Val  Lys Asp Gly Gly Ser  Phe Pro Lys Thr Asp  Ser Thr Thr 
    2540                 2545                 2550             


Val Thr  Val Arg Phe Ala Asn  Lys Ala Asp Phe Pro  Lys Val Arg 
    2555                 2560                 2565             


Ala Lys  Glu Gln Thr Phe Met  Phe Pro Glu Asn Gln  Pro Val Gly 
    2570                 2575                 2580             


Thr Leu  Val Thr Thr Ile Thr  Gly Ser Ser Leu Arg  Gly Glu Thr 
    2585                 2590                 2595             


Leu Ser  Tyr Tyr Ile Ala Ser  Gly Asn Leu Gly Asn  Ala Phe Gln 
    2600                 2605                 2610             


Ile Asp  Pro Leu Thr Gly Gln  Val Ser Ile Ser Gln  Pro Leu Asp 
    2615                 2620                 2625             


Phe Glu  Lys Ile Gln Lys Tyr  Ile Val Trp Ile Glu  Ala Arg Asp 
    2630                 2635                 2640             


Gly Gly  Phe Pro Pro Phe Ser  Ser Tyr Glu Lys Leu  Asp Ile Thr 
    2645                 2650                 2655             


Val Leu  Asp Ile Asn Asp Asn  Ala Pro Ala Phe Glu  Glu Asp Pro 
    2660                 2665                 2670             


Phe Val  Ser Glu Ile Leu Glu  Asn Leu Ser Pro Arg  Lys Ile Leu 
    2675                 2680                 2685             


Thr Val  Ser Ala Thr Asp Lys  Asp Ser Gly Pro Asn  Gly Gln Leu 
    2690                 2695                 2700             


Ala Tyr  Glu Ile Val Asn Gly  Asn Gln Glu Ser Ser  Phe Thr Ile 
    2705                 2710                 2715             


Asn His  Ala Thr Gly Glu Ile  Arg Ser Ile Arg Pro  Leu Asp Arg 
    2720                 2725                 2730             


Glu Lys  Ile Ser Tyr Tyr Glu  Leu Thr Val Lys Ser  Ser Asp Lys 
    2735                 2740                 2745             


Gly Ser  Pro Ser Gln Ser Thr  Ser Val Lys Val Ile  Ile Ser Val 
    2750                 2755                 2760             


Leu Asp  Glu Asn Asp Asn Ala  Pro Arg Phe Ser Gln  Ile Phe Ser 
    2765                 2770                 2775             


Ala Tyr  Val Ser Glu Asn Ser  Pro Leu Gly Tyr Thr  Val Thr Arg 
    2780                 2785                 2790             


Val Thr  Thr Ser Asp Glu Asp  Ile Gly Ile Asn Ala  Ile Ser Arg 
    2795                 2800                 2805             


Tyr Ser  Ile Ala Asp Thr Ala  Leu Pro Phe Thr Ile  Asn Pro Asn 
    2810                 2815                 2820             


Thr Gly  Asp Ile Val Ile Ser  Arg Pro Leu Asn Arg  Glu Asp Thr 
    2825                 2830                 2835             


Asp Arg  Tyr Arg Ile Arg Val  Ser Ala His Asp Ser  Gly Trp Thr 
    2840                 2845                 2850             


Val Ser  Thr Asp Val Thr Ile  Phe Val Thr Asp Ile  Asn Asp Asn 
    2855                 2860                 2865             


Thr Pro  Arg Phe Ser Arg Pro  Ser Tyr Tyr Leu Asp  Cys Pro Glu 
    2870                 2875                 2880             


Leu Thr  Glu Leu Gly Ser Arg  Val Thr Gln Val Ser  Ala Thr Asp 
    2885                 2890                 2895             


Pro Asp  Glu Gly Ser Asn Gly  Gln Val Phe Tyr Phe  Ile Lys Ser 
    2900                 2905                 2910             


Lys Ser  Glu Tyr Phe Arg Ile  Asn Ala Thr Thr Gly  Glu Ile Phe 
    2915                 2920                 2925             


Asn Lys  Gln Val Leu Lys Tyr  Gln Asn Val Ser Gly  Phe Ser Asn 
    2930                 2935                 2940             


Val Asn  Ile Asn Arg His Ser  Phe Ile Val Thr Ala  Ser Asp Arg 
    2945                 2950                 2955             


Gly Asn  Pro Ser Leu Leu Ser  Glu Thr Thr Val Thr  Ile Asn Thr 
    2960                 2965                 2970             


Val Asp  Ser Asn Asp Asn Pro  Pro Gln Phe Leu Lys  Asn Lys Tyr 
    2975                 2980                 2985             


Phe Thr  Pro Val Thr Lys Asn  Val Lys Val Gly Thr  Lys Leu Ile 
    2990                 2995                 3000             


Lys Val  Thr Ala Val Asp Asp  Lys Asp Phe Gly Leu  Asn Ser Glu 
    3005                 3010                 3015             


Val Glu  Tyr Phe Val Ser Asn  Gly Asn His Leu Gly  Lys Phe Lys 
    3020                 3025                 3030             


Leu Asp  Asn Asp Thr Gly Trp  Ile Ser Ile Ala Ser  Ser Leu Val 
    3035                 3040                 3045             


Ser Asp  Leu Asn Gln Asn Phe  Phe Ile Arg Val Thr  Ala Lys Asp 
    3050                 3055                 3060             


Lys Gly  Asn Pro Pro Leu Ser  Ser Gln Val Val Ile  His Ile Thr 
    3065                 3070                 3075             


Val Thr  Glu Glu Asn Tyr His  Thr Pro Glu Phe Ser  Gln Ser His 
    3080                 3085                 3090             


Ile Ser  Ala Thr Ile Pro Glu  Ser His Ser Ile Gly  Ser Val Val 
    3095                 3100                 3105             


Arg Thr  Val Ser Ala Arg Asp  Arg Asp Thr Ala Met  Asn Gly Leu 
    3110                 3115                 3120             


Ile Ser  Tyr Asn Ile Ser Ser  Gly Asn Glu Glu Gly  Ile Phe Ala 
    3125                 3130                 3135             


Ile Asn  Ser Ser Thr Gly Val  Val Thr Leu Ala Lys  Ala Leu Asp 
    3140                 3145                 3150             


Tyr Glu  Leu Ser Ser Lys His  Glu Met Thr Ile Ser  Ala Thr Asp 
    3155                 3160                 3165             


Gly Gly  Trp Val Ala Arg Thr  Gly Tyr Cys Ser Leu  Thr Val Ser 
    3170                 3175                 3180             


Val Ile  Asp Val Asn Asp Asn  Ser Pro Val Phe Val  Pro Asp Glu 
    3185                 3190                 3195             


Phe Phe  Pro Thr Val Met Glu  Asn Ala Pro Ser Gly  Thr Thr Val 
    3200                 3205                 3210             


Ile His  Leu Asn Ala Thr Asp  Ala Asp Ser Gly Ala  Asn Ala Val 
    3215                 3220                 3225             


Ile Ala  Tyr Thr Val Gln Ser  Ser Asp Ser Asp Leu  Phe Val Ile 
    3230                 3235                 3240             


Asp Pro  Asn Thr Gly Val Ile  Thr Thr Gln Gly Phe  Leu Asp Phe 
    3245                 3250                 3255             


Glu Thr  Lys Gln Ser Tyr His  Leu Thr Val Lys Ala  Phe Asn Val 
    3260                 3265                 3270             


Pro Asp  Glu Glu Lys Cys Ser  Phe Ala Thr Val Asn  Ile Gln Leu 
    3275                 3280                 3285             


Met Gly  Thr Asn Glu Tyr Val  Pro Arg Phe Val Ser  Lys Leu Tyr 
    3290                 3295                 3300             


Tyr Phe  Glu Val Ser Glu Ala  Ala Pro Arg Gly Thr  Ala Val Gly 
    3305                 3310                 3315             


Glu Val  Phe Ala Ser Asp Arg  Asp Met Gly Ala Asp  Gly Glu Val 
    3320                 3325                 3330             


His Tyr  Leu Ile Phe Gly Asn  Ser Arg Lys Lys Gly  Phe Gln Ile 
    3335                 3340                 3345             


His Lys  Met Thr Gly Gln Ile  Tyr Val Ser Gly Leu  Leu Asp Arg 
    3350                 3355                 3360             


Glu Lys  Glu Glu Arg Val Ser  Leu Lys Val Leu Ala  Lys Asn Phe 
    3365                 3370                 3375             


Gly Asn  Ile Arg Gly Ala Asp  Ile Asp Glu Val Thr  Val Asn Ile 
    3380                 3385                 3390             


Thr Val  Leu Asp Ala Asn Asp  Pro Pro Val Phe Ser  Leu Asn Thr 
    3395                 3400                 3405             


Tyr Arg  Val Gln Ile Ser Glu  Gly Val Pro Ile Gly  Thr His Val 
    3410                 3415                 3420             


Thr Phe  Val Ser Ala Phe Asp  Ser Asp Ser Ile Pro  Ser Trp Ser 
    3425                 3430                 3435             


Arg Phe  Ser Tyr Phe Ile Gly  Ser Gly Asn Glu Asn  Gly Ala Phe 
    3440                 3445                 3450             


Ser Ile  Asn Pro Gln Thr Gly  Gln Ile Thr Val Thr  Ser Gly Leu 
    3455                 3460                 3465             


Asp Arg  Glu Ser Leu Pro Val  Tyr Asn Leu Thr Val  Leu Ala Val 
    3470                 3475                 3480             


Asp Ser  Gly Thr Pro Ser Ala  Thr Gly Ser Ala Ser  Leu Leu Val 
    3485                 3490                 3495             


Thr Leu  Glu Asp Ile Asn Asp  Asn Gly Pro Val Leu  Thr Val Ser 
    3500                 3505                 3510             


Glu Gly  Glu Val Leu Glu Asn  Lys Arg Pro Gly Thr  Leu Val Met 
    3515                 3520                 3525             


Thr Leu  Gln Ser Thr Asp Pro  Asp Leu Pro Pro Asn  Gln Gly Pro 
    3530                 3535                 3540             


Phe Asn  Tyr Tyr Leu Leu Ser  Thr Gly Pro Ala Thr  Asn Tyr Phe 
    3545                 3550                 3555             


Ser Leu  Asn Thr Ala Gly Val  Leu Ser Thr Thr Arg  Glu Ile Asp 
    3560                 3565                 3570             


Arg Glu  Gln Ile Ala Asp Phe  Tyr Leu Ser Val Val  Thr Arg Asp 
    3575                 3580                 3585             


Ser Gly  Ala Pro Gln Met Ser  Ser Thr Gly Thr Val  His Ile Thr 
    3590                 3595                 3600             


Val Leu  Asp Gln Asn Asp Asn  Pro Ser Gln Ser Arg  Thr Val Glu 
    3605                 3610                 3615             


Ile Phe  Val Asn Tyr Tyr Gly  Asn Leu Phe Pro Gly  Gly Thr Leu 
    3620                 3625                 3630             


Gly Ser  Val Lys Pro Gln Asp  Pro Asp Val Leu Asp  Ser Phe His 
    3635                 3640                 3645             


Cys Ser  Leu Thr Ser Gly Val  Thr Ser Leu Phe Ser  Ile Pro Ala 
    3650                 3655                 3660             


Gly Ser  Cys Asp Leu Ser Ser  Gln Pro Arg Ser Thr  Asp Gly Thr 
    3665                 3670                 3675             


Phe Asp  Leu Thr Val Val Ser  Ser Asp Gly Val His  Ser Thr Val 
    3680                 3685                 3690             


Thr Asn  Asn Ile Arg Val Phe  Phe Ala Gly Phe Ser  Asn Ala Thr 
    3695                 3700                 3705             


Ile Asp  Asn Ser Ile Leu Leu  Arg Val Gly Val Pro  Thr Val Lys 
    3710                 3715                 3720             


Asp Phe  Leu Thr Asn His Tyr  Leu His Phe Leu Arg  Ile Ala Ser 
    3725                 3730                 3735             


Ser Gln  Leu Thr Gly Leu Gly  Thr Ala Val Gln Leu  Tyr Ala Ala 
    3740                 3745                 3750             


Tyr Glu  Glu Asn Asn Arg Thr  Phe Leu Leu Ala Ala  Val Lys Arg 
    3755                 3760                 3765             


Asn His  Asn Gln Tyr Val Asn  Pro Ser Gly Val Ala  Thr Phe Phe 
    3770                 3775                 3780             


Glu Ser  Ile Lys Glu Ile Leu  Leu Arg Gln Ser Gly  Val Lys Val 
    3785                 3790                 3795             


Glu Ser  Val Asp His Asp Pro  Cys Ile His Ala Pro  Cys Gln Asn 
    3800                 3805                 3810             


Gly Gly  Ser Cys Leu Arg Arg  Leu Ala Val Gly Ser  Ala Leu Lys 
    3815                 3820                 3825             


Ile Gln  Glu Ser Leu Pro Val  Ile Ile Val Ala Asn  Glu Pro Leu 
    3830                 3835                 3840             


Gln Pro  Phe Gln Cys Lys Cys  Val Pro Gly Tyr Ala  Gly Ser Trp 
    3845                 3850                 3855             


Cys Glu  Val Asp Ile Asp Glu  Cys Leu Pro Ala Pro  Cys His Asn 
    3860                 3865                 3870             


Gly Gly  Thr Cys His Asn Leu  Val Gly Gly Phe Ser  Cys Ser Cys 
    3875                 3880                 3885             


Ser Glu  Gly Phe Thr Gly Arg  Ala Cys Glu Arg Asp  Ile Asn Glu 
    3890                 3895                 3900             


Cys Leu  Pro Ser Pro Cys Lys  His Gly Ala Val Cys  Gln Asn Phe 
    3905                 3910                 3915             


Pro Gly  Gly Phe Asn Cys Val  Cys Lys Thr Gly Tyr  Thr Gly Lys 
    3920                 3925                 3930             


Met Cys  Glu Ser Ser Val Asn  Tyr Cys Glu Cys Asn  Pro Cys Phe 
    3935                 3940                 3945             


Asn Gly  Gly Ser Cys Gln Ser  Gly Val Glu Ser Tyr  Tyr Cys His 
    3950                 3955                 3960             


Cys Pro  Phe Gly Val Phe Gly  Lys His Cys Glu Leu  Asn Ser Tyr 
    3965                 3970                 3975             


Gly Phe  Glu Glu Leu Ser Tyr  Met Glu Phe Pro Ser  Leu Asp Pro 
    3980                 3985                 3990             


Asn Asn  Asn Tyr Ile Tyr Val  Lys Phe Ala Thr Ile  Lys Ser His 
    3995                 4000                 4005             


Ala Leu  Leu Leu Tyr Asn Tyr  Asp Asn Gln Thr Gly  Glu Arg Ala 
    4010                 4015                 4020             


Glu Phe  Leu Ala Leu Glu Ile  Ala Glu Glu Arg Leu  Arg Phe Ser 
    4025                 4030                 4035             


Tyr Asn  Leu Gly Ser Gly Thr  Tyr Lys Leu Thr Thr  Met Lys Lys 
    4040                 4045                 4050             


Val Ser  Asp Gly Gln Phe His  Thr Val Ile Ala Arg  Arg Ala Gly 
    4055                 4060                 4065             


Met Ala  Ala Ser Leu Thr Val  Asp Ser Cys Ser Glu  Asn Gln Glu 
    4070                 4075                 4080             


Pro Gly  Tyr Cys Thr Val Ser  Asn Val Ala Val Ser  Asp Asp Trp 
    4085                 4090                 4095             


Thr Leu  Asp Val Gln Pro Asn  Arg Val Thr Val Gly  Gly Ile Arg 
    4100                 4105                 4110             


Ser Leu  Glu Pro Ile Leu Gln  Arg Lys Gly His Val  Glu Ser His 
    4115                 4120                 4125             


Asp Phe  Val Gly Cys Ile Met  Glu Phe Ala Val Asn  Gly Arg Pro 
    4130                 4135                 4140             


Leu Glu  Pro Ser Gln Ala Leu  Ala Ala Gln Gly Ile  Leu Asp Gln 
    4145                 4150                 4155             


Cys Pro  Arg Leu Glu Gly Thr  Cys Ala Arg Asn Pro  Cys Gln His 
    4160                 4165                 4170             


Gly Gly  Thr Cys Val Asp Phe  Trp Ser Trp Gln Gln  Cys Gln Cys 
    4175                 4180                 4185             


Met Glu  Gly Leu Thr Gly Lys  Tyr Cys Glu Lys Ser  Val Thr Pro 
    4190                 4195                 4200             


Asp Thr  Ala Leu Ser Leu Glu  Gly Lys Gly Arg Leu  Asp Tyr His 
    4205                 4210                 4215             


Met Ser  Gln Ser Glu Lys Arg  Glu Tyr Leu Leu Thr  Gln Ser Ile 
    4220                 4225                 4230             


Arg Glu  Ala Thr Leu Glu Pro  Phe Gly Val Asn Ser  Leu Glu Val 
    4235                 4240                 4245             


Lys Phe  Arg Thr Arg Ser Glu  Asn Gly Ile Leu Ile  His Ile Gln 
    4250                 4255                 4260             


Glu Ser  Ser Asn Tyr Thr Thr  Val Lys Ile Lys Asn  Gly Lys Val 
    4265                 4270                 4275             


His Phe  Thr Ser Asp Ala Gly  Val Ala Gly Lys Val  Glu Arg Ile 
    4280                 4285                 4290             


Ile Pro  Glu Ala Tyr Val Ala  Asp Gly His Trp His  Thr Phe Arg 
    4295                 4300                 4305             


Ile Ser  Lys Asn Gly Ser Ser  Thr Val Leu Ser Val  Asp Arg Thr 
    4310                 4315                 4320             


His Ser  Arg Asp Val Val His  Pro Thr Gln Asp Phe  Gly Gly Ile 
    4325                 4330                 4335             


Glu Val  Leu Ser Met Ser Leu  Gly Gly Ile Pro Pro  Asn Gln Ala 
    4340                 4345                 4350             


His Arg  Asp Thr Gln Thr Gly  Phe Asn Gly Cys Ile  Ala Ser Val 
    4355                 4360                 4365             


Leu Tyr  Gly Gly Glu Ser Leu  Pro Phe Ser Gly Lys  His Ser Leu 
    4370                 4375                 4380             


Ala Ser  Ile Ser Lys Thr Asp  Pro Ser Val Lys Ile  Gly Cys Arg 
    4385                 4390                 4395             


Gly Pro  Asn Ile Cys Ala Ser  Asn Pro Cys Trp Gly  Asp Leu Leu 
    4400                 4405                 4410             


Cys Ile  Asn Gln Trp Tyr Ala  Tyr Lys Cys Val Pro  Pro Gly Asp 
    4415                 4420                 4425             


Cys Ala  Ser His Pro Cys Gln  Asn Gly Gly Ser Cys  Glu Pro Gly 
    4430                 4435                 4440             


Leu Leu  Ser Gly Tyr Thr Cys  Ser Cys Pro Glu Ser  His Thr Gly 
    4445                 4450                 4455             


Arg Thr  Cys Glu Thr Val Val  Ala Cys Leu Gly Val  Leu Cys Pro 
    4460                 4465                 4470             


Gln Gly  Lys Val Cys Lys Ala  Gly Ser Pro Gly Gly  His Val Cys 
    4475                 4480                 4485             


Val Gln  Ser Gln Gly Pro Asp  Glu Ile Ser Leu Pro  Leu Trp Ala 
    4490                 4495                 4500             


Val Pro  Ala Ile Val Gly Ser  Cys Ala Thr Ala Leu  Ala Leu Leu 
    4505                 4510                 4515             


Val Leu  Ser Leu Ile Leu Cys  Asn Gln Cys Arg Gly  Lys Met Pro 
    4520                 4525                 4530             


Lys Asn  Pro Lys Glu Glu Lys  Lys Pro Lys Glu Lys  Lys Lys Lys 
    4535                 4540                 4545             


Gly Ser  Glu Asn Val Ala Phe  Asp Asp Pro Asp Asn  Ile Pro Pro 
    4550                 4555                 4560             


Tyr Gly  Asp Asp Leu Ala Val  Arg Lys Gln Pro Glu  Gly Asn Pro 
    4565                 4570                 4575             


Lys Pro  Asp Ile Ile Glu Arg  Glu Asn Pro Tyr Leu  Ile Phe Asp 
    4580                 4585                 4590             


Glu Thr  Asp Ile Pro His Asn  Ser Glu Thr Ile Pro  Ser Ala Pro 
    4595                 4600                 4605             


Leu Ala  Ser Pro Glu Gln Glu  Ile Glu His Tyr Asp  Ile Asp Asn 
    4610                 4615                 4620             


Ala Ser  Ser Ile Ala Pro Ser  Asp Ala Asp Ile Ile  Gln His Tyr 
    4625                 4630                 4635             


Lys Gln  Phe Arg Ser His Thr  Pro Lys Phe Ser Ile  Gln Arg His 
    4640                 4645                 4650             


Ser Pro  Leu Gly Phe Ala Arg  Gln Ser Pro Met Pro  Leu Gly Ala 
    4655                 4660                 4665             


Ser Ser  Leu Thr Tyr Gln Pro  Ser Ser Tyr Gly Gln  Ala Leu Arg 
    4670                 4675                 4680             


Thr Ser  Ser Leu Ser His Ser  Ala Cys Pro Thr Pro  Asn Pro Leu 
    4685                 4690                 4695             


Ser Arg  His Ser Pro Ala Pro  Phe Ser Lys Pro Ser  Ala Phe Tyr 
    4700                 4705                 4710             


Arg Asn  Ser Pro Ala Arg Glu  Leu His Leu Pro Leu  Arg Asp Gly 
    4715                 4720                 4725             


Gly Thr  Leu Glu Met His Gly  Asp Pro Cys Gln Pro  Gly Met Phe 
    4730                 4735                 4740             


Asn Tyr  Ala Thr Arg Leu Gly  Arg Arg Ser Lys Ser  Pro Gln Ala 
    4745                 4750                 4755             


Met Ala  Ser His Gly Ser Arg  Pro Gly Ser Arg Leu  Lys Gln Pro 
    4760                 4765                 4770             


Ile Ala  Gln Ile Pro Leu Glu  Ser Ser Pro Pro Val  Gly Leu Ser 
    4775                 4780                 4785             


Ile Glu  Glu Val Glu Arg Leu  Asn Thr Pro Arg Pro  Arg Asn Pro 
    4790                 4795                 4800             


Ser Ile  Cys Ser Ala Asp His  Gly Arg Ser Ser Ser  Glu Glu Asp 
    4805                 4810                 4815             


Cys Arg  Arg Pro Leu Ser Arg  Thr Arg Asn Pro Ala  Asp Gly Ile 
    4820                 4825                 4830             


Pro Ala  Pro Glu Ser Ser Ser  Asp Ser Asp Ser His  Asp Ser Phe 
    4835                 4840                 4845             


Thr Cys  Ser Glu Met Glu Tyr  Asp Arg Glu Lys Pro  Val Val Tyr 
    4850                 4855                 4860             


Thr Ser  Arg Met Pro Lys Leu  Ser Gln Val Asn Glu  Ser Asp Ala 
    4865                 4870                 4875             


Asp Asp  Glu Asp Asn Tyr Gly  Ala Arg Leu Lys Pro  Arg Arg Tyr 
    4880                 4885                 4890             


His Gly  Arg Arg Ala Glu Gly  Gly Pro Val Gly Thr  Pro Ala Ala 
    4895                 4900                 4905             


Ala Ser  Gly Ala Ala Asp Ser  Thr Leu Lys Leu Gly  Gln Gln Ala 
    4910                 4915                 4920             


Gly Asn  Phe Asn Trp Asp Asn  Leu Leu Asn Trp Gly  Pro Gly Phe 
    4925                 4930                 4935             


Gly His  Tyr Val Asp Val Phe  Lys Asp Leu Ala Ser  Leu Pro Glu 
    4940                 4945                 4950             


Lys Ala  Ala Gly Asn Glu Glu  Gly Lys Ser Gly Ala  Ala Lys Pro 
    4955                 4960                 4965             


Ala Ala  Lys Asp Gly Glu Ala  Glu Gln Tyr Val 
    4970                 4975                 


<210>  7
<211>  4200
<212>  DNA
<213>  mus musculus


<220>
<221>  misc_feature
<223>  mouse Yap1 cDNA

<400>  7
gtttgggcgt ctggagccaa agtttctgtc tcagttggga cgccgccgcg gccgggggca       60

aagaaaggga ggaaggaagg agctcgcgga ggggagggga ggagagggga ggcggcctcg      120

ggcaaggagt gcagggcgat gcgggcgcgc gtcgcagccc cccgaacctg agcgcagtgc      180

cccgagcgtc gaacgaggcc gcagccatgg agcccgcgca acagccgccg ccccagccgg      240

ccccgcaagg ccccgcgccg ccgtccgtgt ctccggccgg gacccccgcg gccccgcccg      300

cacccccggc cggccaccag gtcgtgcacg tccgcgggga ctcggagacc gacttggagg      360

cgctcttcaa tgccgtcatg aaccccaaga cggccaacgt gcctcagacc gtgcccatgc      420

ggcttcgcaa gctgcccgac tccttcttca agccgcctga gcccaagtcc cactcgcgac      480

aggccagtac tgatgcaggt actgcgggag ctctgactcc acagcatgtt cgagctcact      540

cctctccagc ctccctgcag ctgggtgccg tttctcctgg gacactcaca gccagtggcg      600

ttgtctctgg ccctgccgct gcccctgcag ctcagcatct ccggcagtcc tcctttgaga      660

tccctgatga tgtaccactg ccagcaggct gggagatggc caagacatct tctggtcaaa      720

gatacttctt aaatcacaac gatcagacaa caacatggca ggacccccgg aaggccatgc      780

tttcgcaact gaacgttcct gcgcctgcca gcccagcggt gccccagacg ctgatgaatt      840

ctgcctcagg acctcttcct gatggatggg agcaagccat gactcaggat ggagaagttt      900

actacataaa ccataagaac aagaccacat cctggctgga cccaaggctg gaccctcgtt      960

ttgccatgaa ccagaggatc actcagagtg ctccagtgaa gcagccccca cccttggctc     1020

cccagagccc acagggaggc gtcctgggtg gaggcagttc caaccagcag cagcaaatac     1080

agctgcagca gttacagatg gagaaggaga gactgcggtt gaaacaacag gaattatttc     1140

ggcaggcaat acggaatatc aatcccagca cagcaaatgc tccaaaatgt caggaattag     1200

ctctgcgcag ccagttgcct acactggagc aggatggagg gactccgaat gcagtgtctt     1260

ctcctgggat gtctcaggaa ttgagaacaa tgacaaccaa tagttccgat ccctttctta     1320

acagtggcac ctatcactct cgagatgaga gcacagacag cggcctcagc atgagcagct     1380

acagcatccc tcggacccca gacgacttcc tcaacagtgt ggatgaaatg gatacaggag     1440

acaccatcag ccaaagcacc ctgccgtcac agcagagccg cttccccgac tacctggaag     1500

ccctccctgg gacaaatgtg gaccttggca cactggaagg agatgcaatg aacatagaag     1560

gggaggagct gatgcccagt ctgcaggaag cgctgagttc cgaaatcttg gacgtggagt     1620

ctgtgttggc tgccaccaag ctagataaag aaagctttct cacgtggtta tagagctgca     1680

gggagccact ctgagtctgt gagggatcca cagagcctaa gatgtgcacg cctgaaattc     1740

agataagtca gtgggggttc tctggctaac acagaaaaca gatgaaccag tgtccatcgt     1800

tgttccgctt ttctctgccc gtcgctgctc ttacgttggt tgctgacctc ttcacggccg     1860

gctctaaaga acccgaaccg cagacagatt cctttgttaa ctctgctatg ataactacgt     1920

tctctgggat tgctggggga tggcctgctg gataatggat gttctgcctt ttgtccggtg     1980

gtcctttcac catcacttta actgaacaca cagactggga actgaatgct ctagaacatt     2040

gttcaagagg tggtttcttc agctgccttg ggtccaacaa gccagaggca ttgcgtctga     2100

tctcgtggag gacggagggg acccacgctg aagactggtg aactttccat tcttctgtta     2160

gcgatgccgt taggccatag tgacctgggt cttatcttag acgcttatga ggcatgagac     2220

agcttccata gaaatatatt aattattacc acatactcta gattaggttt gaatgaatat     2280

tttctgtggg tgttttggtt ggtttttctc tgcccccccc cccttttttg tggttggtct     2340

tggtggaacg taggcaaatt aatgaattcg tttatagctg tagcttgggg tgggcaatac     2400

cattcttttg gtgggaaatc tgtatttctt ggttttttaa catcctattt aaatcttaaa     2460

tcttggttat ctcctctcta catatataca cactcttatt atgtctatgg tagtgtgata     2520

gcagaatata tctttataaa catttctttc ctttccagtt tattttttaa atggtagcct     2580

tgaacatata catttagaca cagtagttta tgtttcacaa atactttaaa ttctggttgg     2640

agcaattgca ggtgtttgag ggagggtggg cagtgttata gaaagggctc tagtgggtaa     2700

agccaagagg cgcctcttgc cctctgtgca ctgtggtgac aacagaagcc aacagtgagt     2760

ggccttactt cccttagcct gatttcatgc catgtagtgt ctgagctgta agctttagag     2820

aggcaggcct gccttctgcc tccacctcag ctttgggtgt acactcagat actgagactg     2880

ataatccacg aggtcaggtt gagtgtcacc tacaagatca tgcttaggaa acctcctccc     2940

gtgtctgctg agtggaccct ggggtagtgt gcagaatgct gcgaggtcat aggtaaagtg     3000

atcagactag caagtgtggg gtagttggac tgagcagagc tacaatgaag catgattatg     3060

gctttatttt tgcaagatta ctagagtatg tgtctccagg agtaataatg gtttccaaag     3120

agtatttttt aaaggaacaa aataggcatg aattaactct gtgtataagc tatgaagtaa     3180

tagttggtta tgaattatag tggcaccagc tagcacctct gtcatttaag ggtctttgag     3240

tgcttctaga agaatccctt attttcaagg gttcataatg aacaacaatt ttcccccctg     3300

gctaaagctg ctactataaa atcctcagct taggaagata gaaatctttt ggccctttga     3360

tttagtatag cacaagaatg aagtagaaaa gttttattca gtactttgag tgctcaaaaa     3420

atacaatcag tgtattatat gtgattcata ggtcagtcat ttgaggccat tgactctaag     3480

gcttttaatt agaaactagt tgaagactca cccttgaatt aagtctgggg aaatggcctc     3540

ccggaggatg cagtgactgt agaacagaga tgaaattcta ctctagttga caattgagca     3600

gatggatgat ccacaacagt gcgtggggaa tgggcagatg ataggcgtgc cgagcgccta     3660

tgattggcca gcagctgcag aataaaggat ggcgtcttct gtgggcagac tagctgtagt     3720

gtggggaggg ggaggggagg tgggcatgag ctgttgaaag gttaccgggc tatgatatag     3780

aaaagctttt atgaacttgt ttctcttcag taaagactta tctcgctctc agtaaagaag     3840

ttcctaagtt tgcagctgct taacctcccc cacaaggtgg atgtgccgtc ttcctcctcc     3900

ctcagcatgg tgcgccttgt tatacctcaa tgtccagcag cccctggtgc ctgacagtgc     3960

tctctgacct tatcaaaccc tccatgctga ctgtgggaga tttaagcacc ctgactctca     4020

ctaaatttga atcacggcct gaacgtagtc tttcttgttg tgtccagcag tgtttaatgc     4080

ttcctggctg tagtaggtag catacaggta agaacttaac tggttattct tgaatttctt     4140

ttacaataaa ccaattttta taatcttaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4200


<210>  8
<211>  5396
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  human Yap 1 cDNA

<400>  8
gccgccgcca gggaaaagaa agggaggaag gaaggaacaa gaaaaggaaa taaagagaaa       60

ggggaggcgg ggaaaggcaa cgagctgtcc ggcctccgtc aagggagttg gagggaaaaa      120

gttctcaggc gccgcaggtc cgagtgcctc gcagcccctc ccgaggcgca gccgccagac      180

cagtggagcc ggggcgcagg gcgggggcgg aggcgccggg gcgggggatg cggggccgcg      240

gcgcagcccc ccggccctga gagcgaggac agcgccgccc ggcccgcagc cgtcgccgct      300

tctccacctc ggcccgtgga gccggggcgt ccgggcgtag ccctcgctcg cctgggtcag      360

ggggtgcgcg tcgggggagg cagaagccat ggatcccggg cagcagccgc cgcctcaacc      420

ggccccccag ggccaagggc agccgccttc gcagcccccg caggggcagg gcccgccgtc      480

cggacccggg caaccggcac ccgcggcgac ccaggcggcg ccgcaggcac cccccgccgg      540

gcatcagatc gtgcacgtcc gcggggactc ggagaccgac ctggaggcgc tcttcaacgc      600

cgtcatgaac cccaagacgg ccaacgtgcc ccagaccgtg cccatgaggc tccggaagct      660

gcccgactcc ttcttcaagc cgccggagcc caaatcccac tcccgacagg ccagtactga      720

tgcaggcact gcaggagccc tgactccaca gcatgttcga gctcattcct ctccagcttc      780

tctgcagttg ggagctgttt ctcctgggac actgaccccc actggagtag tctctggccc      840

agcagctaca cccacagctc agcatcttcg acagtcttct tttgagatac ctgatgatgt      900

acctctgcca gcaggttggg agatggcaaa gacatcttct ggtcagagat acttcttaaa      960

tcacatcgat cagacaacaa catggcagga ccccaggaag gccatgctgt cccagatgaa     1020

cgtcacagcc cccaccagtc caccagtgca gcagaatatg atgaactcgg cttcaggtcc     1080

tcttcctgat ggatgggaac aagccatgac tcaggatgga gaaatttact atataaacca     1140

taagaacaag accacctctt ggctagaccc aaggcttgac cctcgttttg ccatgaacca     1200

gagaatcagt cagagtgctc cagtgaaaca gccaccaccc ctggctcccc agagcccaca     1260

gggaggcgtc atgggtggca gcaactccaa ccagcagcaa cagatgcgac tgcagcaact     1320

gcagatggag aaggagaggc tgcggctgaa acagcaagaa ctgcttcggc aggcaatgcg     1380

gaatatcaat cccagcacag caaattctcc aaaatgtcag gagttagccc tgcgtagcca     1440

gttaccaaca ctggagcagg atggtgggac tcaaaatcca gtgtcttctc ccgggatgtc     1500

tcaggaattg agaacaatga cgaccaatag ctcagatcct ttccttaaca gtggcaccta     1560

tcactctcga gatgagagta cagacagtgg actaagcatg agcagctaca gtgtccctcg     1620

aaccccagat gacttcctga acagtgtgga tgagatggat acaggtgata ctatcaacca     1680

aagcaccctg ccctcacagc agaaccgttt cccagactac cttgaagcca ttcctgggac     1740

aaatgtggac cttggaacac tggaaggaga tggaatgaac atagaaggag aggagctgat     1800

gccaagtctg caggaagctt tgagttctga catccttaat gacatggagt ctgttttggc     1860

tgccaccaag ctagataaag aaagctttct tacatggtta tagagccctc aggcagactg     1920

aattctaaat ctgtgaagga tctaaggaga cacatgcacc ggaaatttcc ataagccagt     1980

tgcagttttc aggctaatac agaaaaagat gaacaaacgt ccagcaagat actttaatcc     2040

tctattttgc tcttccttgt ccattgctgc tgttaatgta ttgctgacct ctttcacagt     2100

tggctctaaa gaatcaaaag aaaaaaactt tttatttctt ttgctattaa aactactgtt     2160

cattttgggg gctgggggaa gtgagcctgt ttggatgatg gatgccattc cttttgccca     2220

gttaaatgtt caccaatcat tttaactaaa tactcagact tagaagtcag atgcttcatg     2280

tcacagcatt tagtttgttc aacagttgtt tcttcagctt cctttgtcca gtggaaaaac     2340

atgatttact ggtctgacaa gccaaaaatg ttatatctga tattaaatac ttaatgctga     2400

tttgaagaga tagctgaaac caaggctgaa gactgtttta ctttcagtat tttcttttcc     2460

tcctagtgct atcattagtc acataatgac cttgatttta ttttaggagc ttataaggca     2520

tgagacaatt tccatataaa tatattaatt attgccacat actctaatat agattttggt     2580

ggataatttt gtgggtgtgc attttgttct gttttgttgg gttttttgtt ttttttgttt     2640

ttggcagggt cggtgggggg gttggttggt tggttggttt tgtcggaacc taggcaaatg     2700

accatattag tgaatctgtt aatagttgta gcttgggatg gttattgtag ttgttttggt     2760

aaaatcttca tttcctggtt ttttttacca ccttatttaa atctcgatta tctgctctct     2820

cttttatata catacacaca cccaaacata acatttataa tagtgtggta gtggaatgta     2880

tcctttttta ggtttccctg ctttccagtt aatttttaaa atggtagcgc tttgtatgca     2940

tttagaatac atgactagta gtttatattt cactggtagt ttaaatctgg ttggggcagt     3000

ctgcagatgt ttgaagtagt ttagtgttct agaaagagct attactgtgg atagtgccta     3060

ggggagtgct ccacgccctc tgggcatacg gtagatatta tctgatgaat tggaaaggag     3120

caaaccagaa atggctttat tttctccctt ggactaattt ttaagtctcg attggaattc     3180

agtgagtagg ttcataatgt gcatgacaga aataagcttt atagtggttt accttcattt     3240

agctttggaa gttttctttg ccttagtttt ggaagtaaat tctagtttgt agttctcatt     3300

tgtaatgaac acattaacga ctagattaaa atattgcctt caagattgtt cttacttaca     3360

agacttgctc ctacttctat gctgaaaatt gaccctggat agaatactat aaggttttga     3420

gttagctgga aaagtgatca gattaataaa tgtatattgg tagttgaatt tagcaaagaa     3480

atagagataa tcatgattat acctttattt ttacaggaag agatgatgta actagagtat     3540

gtgtctacag gagtaataat ggtttccaaa gagtattttt taaaggaaca aaacgagcat     3600

gaattaactc ttcaatataa gctatgaagt aatagttggt tgtgaattaa agtggcacca     3660

gctagcacct ctgtgtttta agggtctttc aatgtttcta gaataagccc ttattttcaa     3720

gggttcataa caggcataaa atctcttctc ctggcaaaag ctgctatgaa aagcctcagc     3780

ttgggaagat agattttttt ccccccaatt acaaaatcta agtattttgg cccttcaatt     3840

tggaggaggg caaaagttgg aagtaagaag ttttatttta agtactttca gtgctcaaaa     3900

aaatgcaatc actgtgttgt atataatagt tcataggttg atcactcata ataattgact     3960

ctaaggcttt tattaagaaa acagcagaaa gattaaatct tgaattaagt ctggggggaa     4020

atggccactg cagatggagt tttagagtag taatgaaatt ctacctagaa tgcaaaattg     4080

ggtatatgaa ttacatagca tgttgttggg atttttttta atgtgcagaa gatcaaagct     4140

acttggaagg agtgcctata atttgccagt agccacagat taagattata tcttatatat     4200

cagcagatta gctttagctt agggggaggg tgggaaagtt tggggggggg gttgtgaaga     4260

tttaggggga ccttgataga gaactttata aacttctttc tctttaataa agacttgtct     4320

tacaccgtgc tgccattaaa ggcagctgtt ctagagtttc agtcacctaa gtacacccac     4380

aaaacaatat gaatatggag atcttccttt acccctcaac tttaatttgc ccagttatac     4440

ctcagtgttg tagcagtact gtgatacctg gcacagtgct ttgatcttac gatgccctct     4500

gtactgacct gaaggagacc taagagtcct ttcccttttt gagtttgaat catagccttg     4560

atgtggtctc ttgttttatg tccttgttcc taatgtaaaa gtgcttaact gcttcttggt     4620

tgtattgggt agcattggga taagatttta actgggtatt cttgaattgc ttttacaata     4680

aaccaatttt ataatcttta aatttatcaa ctttttacat ttgtgttatt ttcagtcagg     4740

gcttcttaga tctacttatg gttgatggag cacattgatt tggagtttca gatcttccaa     4800

agcactattt gttgtaataa cttttctaaa tgtagtgcct ttaaaggaaa aatgaacaca     4860

gggaagtgac tttgctacaa ataatgttgc tgtgttaagt attcatatta aatacatgcc     4920

ttctatatgg aacatggcag aaagactgaa aaataacagt aattaattgt gtaattcaga     4980

attcatacca atcagtgttg aaactcaaac attgcaaaag tgggtggcaa tattcagtgc     5040

ttaacacttt tctagcgttg gtacatctga gaaatgagtg ctcaggtgga ttttatcctc     5100

gcaagcatgt tgttataaga attgtgggtg tgcctatcat aacaattgtt ttctgtatct     5160

tgaaaaagta ttctccacat tttaaatgtt ttatattaga gaattcttta atgcacactt     5220

gtcaaatata tatatatagt accaatgtta cctttttatt ttttgtttta gatgtaagag     5280

catgctcata tgttaggtac ttacataaat tgttacatta ttttttctta tgtaatacct     5340

ttttgtttgt ttatgtggtt caaatatatt ctttccttaa actcttaaaa aaaaaa         5396


<210>  9
<211>  1471
<212>  DNA
<213>  rattus norvegicus


<220>
<221>  misc_feature
<223>  rat Yap 1 cDNA

<400>  9
atggagcccg cgcaacagcc gccgccccag ccggccccgc aaggccccgc gccgccgtcg       60

gtgtctccgg ccgggacccc cgcggccccg cccgcacccc cggcgggtca ccaggtcgtg      120

cacgtccgcg gggactcgga gaccgacctg gaagcgcttt tcaacgccgt catgaacccc      180

aagacggcca acgtgccaca gaccgtgccc atgaggcttc gcaagctgcc cgactccttc      240

ttcaagccgc ctgagcccaa gtcccactcg cgacaggcca gtaccgatgc gggcactgct      300

ggagccctga ctccccagca cgttcgagct cactcgtctc cagcctccct gcagctgggg      360

gccgggacac tcacggccag tggtgttgtc tctggcccgg ccgccacccc tgctgctcaa      420

catctcagac agtcttcctt tgagatccct gatgatgtac cattgccagc aggctgggag      480

atggccaaga cctcttctgg tcagagatac ttcttaaatc acaatgatca gacaacaaca      540

tggcaggacc cccggaaggc catgctctcc caactgaacg ttcctacatc tgccagccca      600

gcagtgcccc agacgctgat gaactctgcc tcagggcctc ttcctgatgg atgggagcaa      660

gccatgactc aggatggaga agtttactac ataaaccata agaacaagac cacatcctgg      720

ctggacccaa ggcttgaccc tcgttttgcc atgaaccaga ggatcactca gagtgctcca      780

gtgaagcagc ccccaccctt ggctccccag agcccacagg gaggcgtcct gggtggaggc      840

agctcaaacc agcagcagca gatacagctg cagcagctac agatggagaa ggagaggctg      900

cgattgaaac agcaggagtt atttcggcag gcaatacgga atatcaatcc cagcacagca      960

aatgctccaa aatgtcagac cgtcagagcg ggaattagct ctccgcagcc agttgccctc     1020

actggagcag gatggaggga ctcagaatgc agtgtcttct cccgggatga ctcaggaatt     1080

gaggacaatg acaaccaata gttcagatcc ctttcttaac agtggcacct atcactctag     1140

agatgagagc acagacagtg gcctcagcat gagcagctac agcatccctc ggaccccaga     1200

cgacttcctg aacagcgtgg atgaaatgga cacaggagac accatcagcc agagcaccct     1260

gccgtcccag cagagccgct tccctgatta cctggaggcc ctccctggga caaatgtgga     1320

ccttggcaca ctggaaggag atgcaatgaa catagaaggg gaggagctga tgcccagcct     1380

tcaggaagcg ctgagttccg aaatcctgga tgtggagtct gtgttggctg ccaccaagtt     1440

agataaagaa agctttctca cgtggttata g                                    1471


<210>  10
<211>  488
<212>  PRT
<213>  mus musculus


<220>
<221>  MISC_FEATURE
<223>  mouse Yap1 polypeptide

<400>  10

Met Glu Pro Ala Gln Gln Pro Pro Pro Gln Pro Ala Pro Gln Gly Pro 
1               5                   10                  15      


Ala Pro Pro Ser Val Ser Pro Ala Gly Thr Pro Ala Ala Pro Pro Ala 
            20                  25                  30          


Pro Pro Ala Gly His Gln Val Val His Val Arg Gly Asp Ser Glu Thr 
        35                  40                  45              


Asp Leu Glu Ala Leu Phe Asn Ala Val Met Asn Pro Lys Thr Ala Asn 
    50                  55                  60                  


Val Pro Gln Thr Val Pro Met Arg Leu Arg Lys Leu Pro Asp Ser Phe 
65                  70                  75                  80  


Phe Lys Pro Pro Glu Pro Lys Ser His Ser Arg Gln Ala Ser Thr Asp 
                85                  90                  95      


Ala Gly Thr Ala Gly Ala Leu Thr Pro Gln His Val Arg Ala His Ser 
            100                 105                 110         


Ser Pro Ala Ser Leu Gln Leu Gly Ala Val Ser Pro Gly Thr Leu Thr 
        115                 120                 125             


Ala Ser Gly Val Val Ser Gly Pro Ala Ala Ala Pro Ala Ala Gln His 
    130                 135                 140                 


Leu Arg Gln Ser Ser Phe Glu Ile Pro Asp Asp Val Pro Leu Pro Ala 
145                 150                 155                 160 


Gly Trp Glu Met Ala Lys Thr Ser Ser Gly Gln Arg Tyr Phe Leu Asn 
                165                 170                 175     


His Asn Asp Gln Thr Thr Thr Trp Gln Asp Pro Arg Lys Ala Met Leu 
            180                 185                 190         


Ser Gln Leu Asn Val Pro Ala Pro Ala Ser Pro Ala Val Pro Gln Thr 
        195                 200                 205             


Leu Met Asn Ser Ala Ser Gly Pro Leu Pro Asp Gly Trp Glu Gln Ala 
    210                 215                 220                 


Met Thr Gln Asp Gly Glu Val Tyr Tyr Ile Asn His Lys Asn Lys Thr 
225                 230                 235                 240 


Thr Ser Trp Leu Asp Pro Arg Leu Asp Pro Arg Phe Ala Met Asn Gln 
                245                 250                 255     


Arg Ile Thr Gln Ser Ala Pro Val Lys Gln Pro Pro Pro Leu Ala Pro 
            260                 265                 270         


Gln Ser Pro Gln Gly Gly Val Leu Gly Gly Gly Ser Ser Asn Gln Gln 
        275                 280                 285             


Gln Gln Ile Gln Leu Gln Gln Leu Gln Met Glu Lys Glu Arg Leu Arg 
    290                 295                 300                 


Leu Lys Gln Gln Glu Leu Phe Arg Gln Ala Ile Arg Asn Ile Asn Pro 
305                 310                 315                 320 


Ser Thr Ala Asn Ala Pro Lys Cys Gln Glu Leu Ala Leu Arg Ser Gln 
                325                 330                 335     


Leu Pro Thr Leu Glu Gln Asp Gly Gly Thr Pro Asn Ala Val Ser Ser 
            340                 345                 350         


Pro Gly Met Ser Gln Glu Leu Arg Thr Met Thr Thr Asn Ser Ser Asp 
        355                 360                 365             


Pro Phe Leu Asn Ser Gly Thr Tyr His Ser Arg Asp Glu Ser Thr Asp 
    370                 375                 380                 


Ser Gly Leu Ser Met Ser Ser Tyr Ser Ile Pro Arg Thr Pro Asp Asp 
385                 390                 395                 400 


Phe Leu Asn Ser Val Asp Glu Met Asp Thr Gly Asp Thr Ile Ser Gln 
                405                 410                 415     


Ser Thr Leu Pro Ser Gln Gln Ser Arg Phe Pro Asp Tyr Leu Glu Ala 
            420                 425                 430         


Leu Pro Gly Thr Asn Val Asp Leu Gly Thr Leu Glu Gly Asp Ala Met 
        435                 440                 445             


Asn Ile Glu Gly Glu Glu Leu Met Pro Ser Leu Gln Glu Ala Leu Ser 
    450                 455                 460                 


Ser Glu Ile Leu Asp Val Glu Ser Val Leu Ala Ala Thr Lys Leu Asp 
465                 470                 475                 480 


Lys Glu Ser Phe Leu Thr Trp Leu 
                485             


<210>  11
<211>  504
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  human Yap1 polypeptide

<400>  11

Met Asp Pro Gly Gln Gln Pro Pro Pro Gln Pro Ala Pro Gln Gly Gln 
1               5                   10                  15      


Gly Gln Pro Pro Ser Gln Pro Pro Gln Gly Gln Gly Pro Pro Ser Gly 
            20                  25                  30          


Pro Gly Gln Pro Ala Pro Ala Ala Thr Gln Ala Ala Pro Gln Ala Pro 
        35                  40                  45              


Pro Ala Gly His Gln Ile Val His Val Arg Gly Asp Ser Glu Thr Asp 
    50                  55                  60                  


Leu Glu Ala Leu Phe Asn Ala Val Met Asn Pro Lys Thr Ala Asn Val 
65                  70                  75                  80  


Pro Gln Thr Val Pro Met Arg Leu Arg Lys Leu Pro Asp Ser Phe Phe 
                85                  90                  95      


Lys Pro Pro Glu Pro Lys Ser His Ser Arg Gln Ala Ser Thr Asp Ala 
            100                 105                 110         


Gly Thr Ala Gly Ala Leu Thr Pro Gln His Val Arg Ala His Ser Ser 
        115                 120                 125             


Pro Ala Ser Leu Gln Leu Gly Ala Val Ser Pro Gly Thr Leu Thr Pro 
    130                 135                 140                 


Thr Gly Val Val Ser Gly Pro Ala Ala Thr Pro Thr Ala Gln His Leu 
145                 150                 155                 160 


Arg Gln Ser Ser Phe Glu Ile Pro Asp Asp Val Pro Leu Pro Ala Gly 
                165                 170                 175     


Trp Glu Met Ala Lys Thr Ser Ser Gly Gln Arg Tyr Phe Leu Asn His 
            180                 185                 190         


Ile Asp Gln Thr Thr Thr Trp Gln Asp Pro Arg Lys Ala Met Leu Ser 
        195                 200                 205             


Gln Met Asn Val Thr Ala Pro Thr Ser Pro Pro Val Gln Gln Asn Met 
    210                 215                 220                 


Met Asn Ser Ala Ser Gly Pro Leu Pro Asp Gly Trp Glu Gln Ala Met 
225                 230                 235                 240 


Thr Gln Asp Gly Glu Ile Tyr Tyr Ile Asn His Lys Asn Lys Thr Thr 
                245                 250                 255     


Ser Trp Leu Asp Pro Arg Leu Asp Pro Arg Phe Ala Met Asn Gln Arg 
            260                 265                 270         


Ile Ser Gln Ser Ala Pro Val Lys Gln Pro Pro Pro Leu Ala Pro Gln 
        275                 280                 285             


Ser Pro Gln Gly Gly Val Met Gly Gly Ser Asn Ser Asn Gln Gln Gln 
    290                 295                 300                 


Gln Met Arg Leu Gln Gln Leu Gln Met Glu Lys Glu Arg Leu Arg Leu 
305                 310                 315                 320 


Lys Gln Gln Glu Leu Leu Arg Gln Ala Met Arg Asn Ile Asn Pro Ser 
                325                 330                 335     


Thr Ala Asn Ser Pro Lys Cys Gln Glu Leu Ala Leu Arg Ser Gln Leu 
            340                 345                 350         


Pro Thr Leu Glu Gln Asp Gly Gly Thr Gln Asn Pro Val Ser Ser Pro 
        355                 360                 365             


Gly Met Ser Gln Glu Leu Arg Thr Met Thr Thr Asn Ser Ser Asp Pro 
    370                 375                 380                 


Phe Leu Asn Ser Gly Thr Tyr His Ser Arg Asp Glu Ser Thr Asp Ser 
385                 390                 395                 400 


Gly Leu Ser Met Ser Ser Tyr Ser Val Pro Arg Thr Pro Asp Asp Phe 
                405                 410                 415     


Leu Asn Ser Val Asp Glu Met Asp Thr Gly Asp Thr Ile Asn Gln Ser 
            420                 425                 430         


Thr Leu Pro Ser Gln Gln Asn Arg Phe Pro Asp Tyr Leu Glu Ala Ile 
        435                 440                 445             


Pro Gly Thr Asn Val Asp Leu Gly Thr Leu Glu Gly Asp Gly Met Asn 
    450                 455                 460                 


Ile Glu Gly Glu Glu Leu Met Pro Ser Leu Gln Glu Ala Leu Ser Ser 
465                 470                 475                 480 


Asp Ile Leu Asn Asp Met Glu Ser Val Leu Ala Ala Thr Lys Leu Asp 
                485                 490                 495     


Lys Glu Ser Phe Leu Thr Trp Leu 
            500                 


<210>  12
<211>  366
<212>  PRT
<213>  rattus norvegicus


<220>
<221>  MISC_FEATURE
<223>  rat Yap1 polypeptide

<400>  12

Met Glu Pro Ala Gln Gln Pro Pro Pro Gln Pro Ala Pro Gln Gly Pro 
1               5                   10                  15      


Ala Pro Pro Ser Val Ser Pro Ala Gly Thr Pro Ala Ala Pro Pro Ala 
            20                  25                  30          


Pro Pro Ala Gly His Gln Val Val His Val Arg Gly Asp Ser Glu Thr 
        35                  40                  45              


Asp Leu Glu Ala Leu Phe Asn Ala Val Met Asn Pro Lys Thr Ala Asn 
    50                  55                  60                  


Val Pro Gln Thr Val Pro Met Arg Leu Arg Lys Leu Pro Asp Ser Phe 
65                  70                  75                  80  


Phe Lys Pro Pro Glu Pro Lys Ser His Ser Arg Gln Ala Ser Thr Asp 
                85                  90                  95      


Ala Gly Thr Ala Gly Ala Leu Thr Pro Gln His Val Arg Ala His Ser 
            100                 105                 110         


Ser Pro Ala Ser Leu Gln Leu Gly Ala Gly Thr Leu Thr Ala Ser Gly 
        115                 120                 125             


Val Val Ser Gly Pro Ala Ala Thr Pro Ala Ala Gln His Leu Arg Gln 
    130                 135                 140                 


Ser Ser Phe Glu Ile Pro Asp Asp Val Pro Leu Pro Ala Gly Trp Glu 
145                 150                 155                 160 


Met Ala Lys Thr Ser Ser Gly Gln Arg Tyr Phe Leu Asn His Asn Asp 
                165                 170                 175     


Gln Thr Thr Thr Trp Gln Asp Pro Arg Lys Ala Met Leu Ser Gln Leu 
            180                 185                 190         


Asn Val Pro Thr Ser Ala Ser Pro Ala Val Pro Gln Thr Leu Met Asn 
        195                 200                 205             


Ser Ala Ser Gly Pro Leu Pro Asp Gly Trp Glu Gln Ala Met Thr Gln 
    210                 215                 220                 


Asp Gly Glu Val Tyr Tyr Ile Asn His Lys Asn Lys Thr Thr Ser Trp 
225                 230                 235                 240 


Leu Asp Pro Arg Leu Asp Pro Arg Phe Ala Met Asn Gln Arg Ile Thr 
                245                 250                 255     


Gln Ser Ala Pro Val Lys Gln Pro Pro Pro Leu Ala Pro Gln Ser Pro 
            260                 265                 270         


Gln Gly Gly Val Leu Gly Gly Gly Ser Ser Asn Gln Gln Gln Gln Ile 
        275                 280                 285             


Gln Leu Gln Gln Leu Gln Met Glu Lys Glu Arg Leu Arg Leu Lys Gln 
    290                 295                 300                 


Gln Glu Leu Phe Arg Gln Ala Ile Arg Asn Ile Asn Pro Ser Thr Ala 
305                 310                 315                 320 


Asn Ala Pro Lys Cys Gln Thr Val Arg Ala Gly Ile Ser Ser Pro Gln 
                325                 330                 335     


Pro Val Ala Leu Thr Gly Ala Gly Trp Arg Asp Ser Glu Cys Ser Val 
            340                 345                 350         


Phe Ser Arg Asp Asp Ser Gly Ile Glu Asp Asn Asp Asn Gln 
        355                 360                 365     


<210>  13
<211>  8951
<212>  DNA
<213>  mus musculus


<220>
<221>  misc_feature
<223>  mouse Amotl1 cDNA

<400>  13
accagcgacc ctcctgggta gcacgctggc gactgggagc gcggggcgcc cagggacccg       60

gcagcggggt ggggtgggtg ggactggagg gggaacgggg catctctctg ctgcccgagt      120

gcagaggcac ccttcgccgc gcctcccagc cgccatcccc ctgccgccat tcccctgccg      180

ccgcgttgcc caagccagga tcgtcccatg atcgccccat gcggagggca aagtcgcgcc      240

ggggaccttg cgagcctgtg cttagagctc ctcctcccat ctgctacagc cccagcagtc      300

ctgtgcagat tctagaagac cccgcctact tctacccaga cttgcagctc tattctggga      360

ggcatgaagc atctactttg acagtggagg caagtggagg cctaaggggg aaaagcgtag      420

aggaccctct ctccagcttc cactccccga acttcctgag gacgcccgag gtggaaatga      480

gaggttctga ggatgtagcc tctggaagag tgttacagcg gctgatccag gaacaactgc      540

gctatggcac cccaactgag aacatgaacc tgctggccat tcagcaccag gccacaggga      600

gtgcagggcc agcccacgcc accaccaact tttcttccac ggaaaccctc actcaagaag      660

atccacaaat ggtctatcag tcggcccgcc aagaaccgca gggtcaagag catcagggag      720

acaatacggt gatggagaag caggtccggt ccacacagcc tcagcagaac aacgaggagc      780

tccccacgta tgaggaagcc aaggcccagt cccagttctt caggggacag cagcagcagc      840

agcaacagca gcagcagcaa cagcagcagc aacagcagca gggacagggg ccccttagcc      900

acacttatta catggccgga ggtaccagtc agaagtcccg cactgagggg aggcccacag      960

tgaaccgggc caacagtgga caggcgcata aggatgaggc cctgaaagaa ctaaagcagg     1020

gccatgtccg gtccctcagt gagaggatca tgcagctgtc actggagagg aatggggcta     1080

agcaacacct ccccagctct ggaaatggaa agagcttcaa agctggagga gagccatccc     1140

cagctcagcc tgtctgtaaa gcactggacc ctcgtggccc tccacctgaa taccccttca     1200

agaccaagcc aatgaaatcc ccagtcagca agaaccaaga tcacggtctt tactacaatg     1260

accagcaccc tggggtactc catgagatgg tcaaacctta cccagcacct cagcctgcga     1320

gaacagaagt ggccgtcctg aggtatcagc cacccccgga gtatggcgtc accagccggc     1380

cctgccagct gccttttcca tctacggtgc agcagcatag ccccatgtcc tctcagacct     1440

cctccatcgg tggtactctg cactccgtct ccctgcctct tccacttccc ataagcctgg     1500

cggcttcaca gcccctacca gcctccccca accagcagct tggaccggat gcctttgcga     1560

ttgtggagcg agcccagcaa atggtagaga tcctgacaga ggagaaccgt gtgcttcacc     1620

aggagcttca gggctgctat gacaacgctg acaagctcca caagtttgaa aaagagctgc     1680

agagtatttc ggaggcctac gagagcctgg tcaagtccac caccaagcgt gagtctctgg     1740

acaaggcaat gagaaccaag ctcgaaggcg agataaggag acttcatgac ttcaacagag     1800

atctccgaga tcgactggag acagccaaca ggcagctgtc cagcagggaa tacgatgggc     1860

atgaagacaa agctgcagag agccattacg tgtcccagaa caaagaattc ttgaaggaaa     1920

aggaaaagtt ggaaatggag ttggcagcag tgcgtacggc aagtgaggac catcggaggc     1980

acatcgagat cctggaccag gctttgagca atgcgcaggc tagagtgatc aaactggagg     2040

aagagttacg agagaagcaa gcctatgtgg aaaaggtgga gaagctgcag caggccctga     2100

cccagctgca gtcagcgtgc gagaagcgag ggcagatgga acgcaggttg cggacctggc     2160

tggagaggga gctagacgct ctgaggacac agcagaaaca tggcacaggc cctccagtca     2220

gtctcccaga atgtaatgct cctgccctca tggagctggt gagggagaag gaggagcgga     2280

tcctcgcctt ggaggccgac atgaccaagt gggagcagaa gtacctggaa gagagcacca     2340

tccggcactt tgccatgagc gcagctgccg ctgccacagc cgagagggac accaccatca     2400

gcaaccactc gaggaatggc agctatgggg agagctccct ggaggcccac atctggccag     2460

aggaagaaga agtggtgcag gccaacagga ggtgtcagga catggagtac actattaaaa     2520

acctccatgc caaaatcata gagaaggatg ccatgataaa ggtcctgcag cagcgatccc     2580

gtaaggatgc tgggaagacg gactctgcca gcctgaggcc tgcccgctct gtcccatcca     2640

tcgctgcggc cactgggaca cattctcgcc agacttctct taccagcagc cagctgacag     2700

aagagaaaaa ggaagagaag acgacctgga aagggagtat aggattcctg ctgggaaagg     2760

aacaccaggg acaggcatct gcccctctgc tgccgaccac acctgcctct gcattgtccc     2820

ttccggcctc taccacatcg gccagcagca cccacgccaa gacgggcagc aaggacagca     2880

gcacacagac cgacaagagc acggagctct tctggcccag catggcttcc ctccccagcc     2940

gtggcaggct gagcacagcc ccttccaaca gccccatcct aaagcatcca gctgccaaag     3000

gagccgtgga gaagcaggag aactctcctg gtcatgggaa ggcatcggag cacagaggcc     3060

gagtcagcaa cttgctgcac aagcctgagt tcccagatgg cgagatgatg gaagtgctca     3120

tctagcgtcg tcctgtggcg cttgccagca tgctgacaga tgagaacaga ggctgaaaga     3180

agagctccag atgggcagtt gcagtagcaa ctgcaaaacc aggacaggtg tggactcgtc     3240

acaatgttac caaaacagct ggctcactat ctgcagaggg agtgagagag gacgcatgta     3300

ggcttggaag cagagtagag aaggaggagg agtggaattt tccattgtag agaaattgta     3360

tgtcttaggg aggctccatg cttccccatt cttggcttat aaacagatga agaagagctg     3420

ggccttcctt ggaatcccct tgttcccttt gccttttagc aggtttggtt taagaagaat     3480

ctgctagaaa tcctgaaagc ccatctcggc ataatggtgt gtgtgtgtgt gtgtgtgtgt     3540

gtgtgtgtgt gtgtgtgtgt gtgtggtgtc cttagcaaat acatccagga taatggggaa     3600

tttcaagttt tgtcaccttc ttggctgttt cgtttgtggt ttgtgatttc agagagtgtg     3660

aagctttgct tgtttggatt ggatggtatt ttctaagcag gatgtgagca agatgccctt     3720

gccctcaccc atcctgattt ctttgagctt atctgtctca tctctactta ctattttatt     3780

gttgtatttt tcctgtttaa ttagacatag cagagttcct tatatatggg acttaggaga     3840

ctaccatcct tgctgtggtg tccagatgga cagagcctcg tgttggcacc ccaactgctc     3900

ttcccacctt tgcttagcag aactgcagct gtcagcctta ttgtgagcta gagatacctg     3960

gctgaggagt ccatgagttg ctgacataac atcatgcctc tgatgtgcat ctctctcacg     4020

tccacactct tgctaggagg ttgacaatta caccccatcg ccctgtgggg aagacttcct     4080

tgtgaatagg tgccacagga acccatgatg gcttacccag agctctctag gtagcatggg     4140

aggtctcagc aggcatcccc agcctttctt gtatttgaag ctctcaggtg gtcttttgtt     4200

gctctcccct gccccattct gccctggttg ctgttgataa gcacagtgcc atccctgatc     4260

aattcttttt ccctgtgaat ttgtttcata acccatcaga ctggtagaca cacagcacaa     4320

tcagtatcac agaaagggac acgacttacc tgaagtgagg cagcaaagtc atggaaatga     4380

gtccctatga acaagaggca ggacctgagg ctgctgccac aagctctcat gttcattgct     4440

gtggaagctg gcttcctgga aaccccagaa gaagctgccc aggggagggt gaactatctc     4500

cagatcagta aggtttattt ccaagtcccc ttcctcatca ctcctttttg gctcaagaga     4560

aaaatgaaaa gtggtaattc tgtgacgtca agtccctctt aagtgcagca ctgaaaatag     4620

cttggctcag agagctctgc ttggatcatg tgtcctagga ctcatctcta ggatgagact     4680

gtggcctccc caggttgagg tggtacatgt attgtgagag acgtagcctg gagaacagag     4740

aagaagagag gcaaggggag gagagagcag tggtgtttcc ctacaggacc ctggaccatc     4800

tgacaagaca gaggaggtgg gactagacta cccacactcc acttggcagt gggaaccagg     4860

ctgggagcct cccaccccct ccttaactct tctctcagat cttgcagcct gagtactgag     4920

cttgccctgt gccttgtggg gaagggagtg agaaggcagc ataagaggtc ttgccagttg     4980

agacagaagc aggtaggtgc aggaactatt ttggataggg catgttgttc agttgatggc     5040

aactaattct cttaagaaca tattgtctcc tattaatgtt ggggacaaac ccagaaaggg     5100

aagggtatag agatggggaa ttggtgagat cttccagccc tgagaccatg tctgagccac     5160

cccaaactta ggctatctcc cagcatagga gtgagacact gcccagttta ctcaaattct     5220

agtgtacgtg ttccagacac attgcacaca cagacagaaa gtctcctgtt ccagccccct     5280

gcctccctgc gttgtcagtc tgtttcagtt gtctgaaaac aaaggggaca cagaccaggg     5340

ctttaactgc aagtgaactg tggcttttgt tcaagagtcc gtgttgagag agatgggcta     5400

tgggctttca gatagaggcc cttcagtctt ctgtccttgt aattctcttg aagggtgcat     5460

gatagaggag ccccaggcac tcgggagcct cgctgtgctc tggggagttc atgggatcta     5520

aactctttcg acaccaaaca acagtactac ataggtattt tggtacaaac tgaaagcact     5580

agaaaaagtg cctgttgaat ggtcctcaaa gcaccagaga aacgaggcca ggttctccct     5640

cctggttgtt cagatgcaga agctggaccc aggaggcata cagcccatct ccaagcttca     5700

cttaaagcaa agactcagaa caagaggctc agtcacaggc tgcacggcct tgaacatgcg     5760

cagcgctatg cctggtgctc tgtggcccaa tttgtgatac ttgtgtgcac acagggaagc     5820

tgtcacacct ctcagggcct gaaaacagga ctaaacccaa gcctcatata actaaccaca     5880

ccgccaccat ccacaggcgt ggatggaagt cttcatgttc tgttataagc acaactacaa     5940

agcaaattaa aaaaataaat aaataaaagt ccttcctcat agtgcagaag gctcgttttc     6000

agatctcttg gagcatttga tcatagaact tgagggtctt ctcttgggat aaagaaagga     6060

taaataaagg ctgtggcact tagtggtggt tggccagcat cctgctttgt ccttgagtga     6120

gcagtgtggt gatgtctgaa tacttccagg tgtcgtgtgg aacctgagaa gtattgagat     6180

catgtctctg tccctgtggt ttcagtaagt agattcttct atgtgtaagc actatttctc     6240

tctggaggtt catagcacta agctgccaag aaaaacacgt tcatttgcaa agaattaaga     6300

gtgtgtgcta aacacttgac attgttcttt gtttctcaga agctagtgac cagcaacgtg     6360

gagtgttcag caagtcccca ccatgcctgc agggtggggc tgctcccttc cacacccagc     6420

tttccttagg ggtggagaca gggaatggtg ggacctgtgt tgttccgtcc cgcagaggtc     6480

tctctttgga gcccatgtat aaggcttgac atttttctgt gagtagattt agaggcagtt     6540

gttccaagtg aattctggcc tcagtacaaa gaatccagtg gttctgacac tcgggacaaa     6600

agctctggta tcccctgtag agaggctctg tcctgctttg ctccagccac tcacacatag     6660

ttaataaagt ggctgaagct cctcccttcc cagagctgct gtgctgggga cgctgtctgc     6720

agcccgcccg agtcccagag attggtgtga gcagtcagat aaggctgatc tgggagacgg     6780

aggaggtggc catgacacaa ggtgttgtca ggagaagatg attgtgacac aaggtgttgt     6840

caggaggaga tgactgtgac acaaggtgtc ttcaagcagc tcctttgtga gtaggctgca     6900

gagagccatc ctgagtggga ggttgtgttg tttaaacaca tggtgtcttc tttgtctgca     6960

ctggatggag cagggtttgt ttctatgtgt tctccaggtg agctcacacc ctctttaaga     7020

aaaggggtct tgtggatgtt ggaagcaagg tctgtcaaac attcttaaat ggtgatgcta     7080

gagaaaagcg agccccctgt aacttcccta aaagccgact cagccactaa gtatacatgt     7140

tgactttctt ctactttttt tctagttaat cagtgtgatt taaatgtctt tagctgatgt     7200

gaggactttt taaaaggcag tagtttgtgg tgcagctccg tggaacaggt tgtgtaataa     7260

gaaacctcag aagccaggct tcaagggggc cgggtgtgtg tgtgtgtgcg gggtgcaccc     7320

aggccagcct ttcagtggat tcctattctc atttagtaat tgaatggtat attacattat     7380

atgtaagtgc atacatataa ggtggaattt ttctcaatat aaaaaaagaa agaaagaaag     7440

aaagaaagaa agaaagaaag aaagagaaaa agaaagaaag aaatgtaaga aagagaaaga     7500

aatccttttg ttttcctgtg agctcgctcc ttggggagga ctacagggct ccccatgtaa     7560

aatggctgtt gactcctcta gcacaatggc ctccaaggtc tggcctgctc ctcggattcc     7620

ctttgaagtg agaggtcatt gtcttttgag aatggattta agttttgaaa atagcccaca     7680

ttgttccagc acaagggaac gaacataggg caactagtca gaatcagaac cccagggcca     7740

tcagatgact tggtgaaaag gcacttccac caaagccaag acctgagttt gatccccagg     7800

aaccccatag taggagagag ccaactgcag caagttgtcc tctgactcag acacacacac     7860

acacacacac acacacacac acacacacgc gcgcgcacgc gcgcgcacat acatacacat     7920

gcacacacac acttacatgc acacacatga acatgcacat gcacacacac acatgcatac     7980

atacatacac atgcacacac acatatatgc acacacatga acatgcacac acacatacat     8040

gcacacacac atacatgcac acacatgcac acgcacacac tcgtgcgcac acacagtttt     8100

tagaagacta cctaatgtgt aggaaaaggg ttattagtac ctgcaacctc tagggcctcg     8160

ttttcaagcc cgcttctctc tccaggcttc atatgtgtgc aacccctgca tacactacag     8220

acctaagtac atataaatat gaacagccaa taggtactct gtaaaatgga tattcttaag     8280

tgcatgttat tgttgtgtgt gccgtgactg aggtgtgtgt tcgtcatgag actttgcttc     8340

ttagctgaat taagactctg ccctccctcc gaggcaggaa ataggctgca gcttctggaa     8400

tcagcttctc acgttttccc gcctttgttg tgtttactcg tggctttgtc tgagagtctg     8460

ttctcacata cacacctgta agtatttatt acaaggtaga atggggacag gcagccacag     8520

tacttgtatt tgaatgtttc cagggaggga caatggagcc ccctcctcag tgaggtgctc     8580

acagaatctg tgtcaaattc tgtgaaccag ggccaacact ggtaccagct tcaccctgac     8640

ctggggccac tgccctctct ctccactgcc ttgtgtgtgt ataggtgtgg ttgtgtgtgt     8700

gtgtctctgc tgggggcatg tgccgcactt cccagcggac tctggtatcc atgtgtaacc     8760

tttggcacct gtgttactgg actgcattga caggtggtgt acagatctgt acagatgggt     8820

ctgtgtgaag agttggggag tcccccccac agtgaatatg gatactgttg gtcagccaaa     8880

gattttccta ttctttgctg cttaaacttt gtgccttaat attgtaaata ataaatgttt     8940

aaaacagcaa a                                                          8951


<210>  14
<211>  8999
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  human Amotl1 cDNA

<400>  14
cggacggcgg cgggagcgcg cgagaagctc taggacccag cagcggttgt cgggtttggg       60

gctggaggtg aagccctgtg tgaatggggt tgattgtccg gcgccacttc cccgcgctgc      120

ccggcagccg tcttccccag ccgagggact gaactagcca tgatcgcctc atgtggaggg      180

caaagttgcg ccggggaact tgtgagcctg cggtgaaagg gtccccttct gcttgttata      240

gccccagtag tcctgtccag gttctagaag actccaccta cttttcccca gactttcagc      300

tctattctgg gaggcatgaa acatctgctt tgacggtgga ggcaaccagt agcatcaggg      360

aaaaagttgt tgaagatcct ctttgtaact tccactcccc aaacttcctg aggatctcag      420

aggtggaaat gagaggttcc gaggatgcgg cagctggaac agtattgcag cggctgatcc      480

aggaacaact gcggtatggc accccaaccg agaacatgaa cttgctggcc attcagcacc      540

aggccacagg gagtgcagga ccagcccatc ctacaaacaa cttttcttcc acggaaaacc      600

tcactcaaga agacccacaa atggtctacc agtcagcacg ccaagaaccg cagggtcaag      660

aacaccaggt ggacaatacg gtgatggaga aacaggtccg gtccacgcag cctcagcaga      720

acaacgagga actgcccact tacgaggagg ccaaagcaca gtcgcagttc ttcagggggc      780

agcagcagca gcaacagcag cagggggcgg tgggccatgg ttactacatg gcagggggca      840

ccagtcagaa gtcccgaact gaggggaggc ccactgtgaa ccgtgccaac agtggacagg      900

cgcataagga cgaggcgctg aaggaactga agcagggcca cgtccgctcg ctcagcgaga      960

gaatcatgca gctgtccctg gagaggaatg gggccaagca acaccttccc ggctcgggga     1020

atggaaaggg cttcaaagta ggaggggggc cctcccctgc ccagcctgca ggtaaagtgc     1080

tggaccctcg gggtcctcca cctgagtacc ccttcaagac caagcaaatg atgtccccag     1140

tcagcaagac ccaggagcac ggactttttt atggtgacca gcaccccggg atgctccacg     1200

agatggtcaa gccctaccct gctcctcagc ctgtgagaac agatgtggcc gtcctgcggt     1260

accagccacc ccctgagtat ggggtaacga gccgcccatg ccaacttccg ttcccatcaa     1320

ccatgcagca gcacagcccc atgtcctccc agacctcttc cgccagcggg ccactgcact     1380

ctgtctccct gccgcttcca ctcccgatgg ccctgggtgc tccacagccc ccgcctgccg     1440

cctcccccag ccagcagctt ggtccagatg cctttgcgat tgtggagcga gcccagcaaa     1500

tggtggagat attaacagag gagaaccggg tgcttcacca ggaacttcag ggttactacg     1560

acaatgccga caagctccac aagtttgaaa aagaacttca gagaatttcg gaagcctatg     1620

aaagtctggt caagtctacc accaagcgag aatcgctgga caaggccatg agaaacaaat     1680

tggaaggcga gattagaaga cttcatgatt tcaacagaga cctccgagat cgactagaga     1740

ctgctaacag gcaactatcc agcagggaat acgaagggca tgaagacaaa gctgcagagg     1800

ggcattatgc ttcccagaac aaagaattct tgaaggaaaa ggagaaatta gaaatggagt     1860

tagcagcagt gcggactgca agtgaggacc atcggagaca catcgagatc ctggaccagg     1920

ctttgagcaa cgcccaggcc agggtcatca agctggaaga ggagttacga gagaagcaag     1980

catatgttga gaaagttgag aagctgcagc aggccctgac ccagctgcag tctgcatgtg     2040

agaagcgaga acagatggag cggagactgc ggacttggct ggagagagag ctggatgcac     2100

tgagaaccca gcagaaacat ggaaatggcc agccagccaa catgccggaa tacaatgccc     2160

cagccctcct ggaacttgtg cgggagaagg aggagcggat cctggccctg gaggccgaca     2220

tgacaaagtg ggagcagaag tacctggagg agagcaccat ccgacacttt gccatgaatg     2280

ccgcagccac tgcagcagct gagagggaca ccacgatcat caaccactca cggaatggca     2340

gctacggaga gagctcgctg gaggcccaca tctggcaaga ggaggaggag gtggtgcagg     2400

ccaacagaag gtgtcaggac atggaataca ctattaaaaa tctccatgcc aaaatcatag     2460

agaaagatgc tatgattaag gtcctgcagc agcgatctcg taaagatgcc gggaagacag     2520

actcctccag cctacgtcct gcccgctccg ttccatccat agcagcagct actgggacac     2580

actctcgcca gacctctctt accagcagcc agctggctga ggaaaagaag gaagagaaga     2640

cctggaaggg gagcatagga ttgctgctgg ggaaggagca ccatgagcat gcctctgccc     2700

cactgctgcc acccccaccc acctcagcac tgtcctccat agcctccact acggcagcca     2760

gcagtgccca cgccaagaca ggcagcaagg acagcagcac acagactgac aagagtgccg     2820

agctcttctg gcccagcatg gcctcccttc ccagccgcgg ccggctgagc acgacccctg     2880

ctcacagccc cgtcctgaaa cacccagcgg ccaaagggac cgcagagaaa ctggagaact     2940

ctcctggcca tgggaagtcg cctgaccaca gaggccgggt cagcagcttg ctgcacaagc     3000

ccgagttccc tgatggagag atgatggaag tcctcatcta actgccatcc ctgtggaatt     3060

tcagtacaga acactgacaa acaaggaaag cggcagagaa agaagaaaga cctagaaggt     3120

tgtagatggg aaatcaggaa tgatttgaac tgataaagat ttcagactca taagaacaca     3180

ttttataaat gttaaacaca aaaactacat gactgaagat agaagagaat gcgatggatt     3240

ttattacaca tggtggaaga gagaagaggc gtgtaggttt gcaaacaaag ttaagaaata     3300

ggaaactgaa tttttcattg tacagaaaat gtatctcttg gggagggcct gtgtaccccc     3360

attctctgat tataaacaga taaacccaaa tgtggatcat ccttggaata cccccattct     3420

ccttgcctct tagcatgttt gatttaagaa aagcctccag gaaatcttga gagcctgtct     3480

tggcataatg cagtgtcacc tgtgccaacc atggggtgtc ccgtgagtgt gagtgtggca     3540

gtgagaagaa gcatcgaggg cgaggggaat atgaaagttg gtcttcacct aattacctgt     3600

ttggtttgga ttttcaagag atgattgggc ttcttagctt ttctgaattc tgcagtattt     3660

tctaaacagg atagattatg atctcggtcc ccatccatcc taacttctga gttcatctct     3720

gtctctgctt tacagtcttt aattttttgt tgttccttca tttttttctt tttaataaga     3780

catagcagaa ttccttaggt atgggattta tgagaccagt acctgaactg tcatcattcc     3840

tactgtgttt gatagtgacc agtaggacaa agccacgtgc cgacttcctg gctgcttcac     3900

ctttgcatag ctgggttgca gctgcgaacc tcattctgac tgtgaactaa gcaagctttg     3960

aggaggcagg agattccgtg ggtccctgtg acatattgca ttaagatcgt ggcacttgct     4020

tttttgtctt tcacatcggc tgtcttgcaa ggagcttgac atttccaaat tccattgctc     4080

tgtttgggga agacttagga cagcactcca ggaaacagat gacaatttac agacagttgt     4140

ctcagtggtt tccagaatct caccagcctc ccgtatagct tcttgtattg aggctcatga     4200

gcgtattcac actctttcct cccccgcgca cgcctctgct tgctctcgat cagcatccag     4260

acctccgtgg caccaggttg cctctgttgt gaacttcttt tgtaacctac caggccagtt     4320

gtatatacag tgttgtcagg tttttccggg tttcagtttt gaggcagttt attcaaagtg     4380

agacagaagt gccacggaaa agaggcagga gtgtgttagg tggtgggtcc attagacctc     4440

tgctgtgaca ttgcatattc agctctgcag acactggctt cctttacaaa tctaagagat     4500

gctggattag aaaagaggag aagctcatcg ggccatcaga gagatgctcc tacagggtcc     4560

tgatgttttt gtacctccag gtcagctgga tcgctgtttt cccagttccc tttgctcatg     4620

cttacttaga ggaagaaaga aaggggggta cctcttccaa gtaccttcta aatgaaacac     4680

tcaagagagt gctactcagg aaactttgct tggatcctaa aatggactgg tcttgggtgt     4740

gtaaccccgg tgaagttata gcctccccaa attgaggtga cagaaggaag acaagaggtg     4800

taagctggag agggaaggga agaaatcagt ggctttggcc agcctctgtg ccacccagta     4860

cgacagagga gtgggaactg gccctctggg gctctgcttg gccataggca ctgcacattg     4920

tgccacctgc tcatcacctc ctctagtctc acactgagca tcggagtacc tgttgtgcag     4980

acaggaaaac tgaggagctc tgagaggctg agcatggagc tcaccccatg ccatagggtg     5040

tgggaagagg gcacaggagg cctcatccat gggggaaagg gttgaggatg gacatgggtg     5100

gggagagggc atagacatcc cttcctaatc tctgttccca ccacatttca taggagatga     5160

gttaggagat gacagctaac tctcttaagg acattttgac cccagtttat gttggggatg     5220

gaccagaaag gaaaatgtct agagatagga aggtaaatca actctgccag cccctaccat     5280

caggtctggg ccaccccaaa cttgggctgc ctcccttaga cataggttag agtgagagac     5340

ccagctgttt ctcccgaagc ctcgtcttca tgccccagac acctgattgc cccaatcagg     5400

tgtcagactt gcttgctctt cgaggtcccc ctgagctgcc aagtgttttc attgtaaaca     5460

gacacatcgc catgtttcag ggcttcaacg gcattgtatt ttggactttg accgtatttt     5520

ttttctctta acctactgag actcttcctt aagaacagga tctatagctt taaaatgtct     5580

tcttctatgg gaaatttcct gccaagccag ggcactaaat tctttcatca ttagagcttt     5640

cctgaagtcc ggccatatac tgagtacctg ctctgagttc tgggcagctt acaatatctt     5700

aaacagattt tcagaaaaat aatgcaacta tattttctag tgtcaactgt atgcaaacag     5760

tgtggtaaat accttttaat tagtcctcca cccacctgga gtacaggggg tgcgtttatt     5820

attctgattt cactgatgag gaaatgggct cagaaaggtt aagtcccttc ctgaaatctc     5880

acagccagga gaagctagga tgatttaaaa caaagtttgg agaggcactg ggcatagacc     5940

ctggctgtac agcctctaac atgcggcact gcatcttggc agtctctatg cctgtctgtg     6000

atgtgtgtgt gcacgtgtaa ctacacacac acacacacac acacacacac acacacacag     6060

ctatcacaca tctcagagcc taagaaatag gactaagccc agaactccta gaatcaccta     6120

taaatgctag gcatagatgg aaattattgt gttccaccag aagcacagct ccaaactata     6180

cctaaaaaat atttctgcac ttcccagaga cctggacttc aaactttccc agtggagcct     6240

gattatagaa cttgagggtc ctatctcagg atgaagggga gaggccctgg cttcacggga     6300

aggtattcca gcattgttct gcttcaccct tgactgcgtt gtctggcagt ttctgtgtgc     6360

tgccaggata ttatatggaa ctggagaagt tggagtcagg tctctgaagc tagagtttca     6420

ctaattagat gcctctgtac atgagaacta ttactgtctg caggtccata tagctaagct     6480

gccaggaaaa acacattatc ttccaaaact ttcagagcat gtgcagaacc ctttcttagc     6540

gttttcttct cagcattttc tctgcctccc agaggctggc agccagtgac actgcagagt     6600

tcagcatgtt ctaaccatgc acgcagggca ggggctgcct tggccctcct caggctttcg     6660

ttgggagagc aggcagtggt ggagcccttc tgggtgcagt cctctggggt tgctctttgg     6720

aactcatgta tgagtttgac tccacaaggc ttggcatgga taccaaaaca gttgcaacaa     6780

attagttctg aacctggaac agagaattca gtgcttctgt tactcaggaa ggaggtgttc     6840

agaatgcccc gtgcagagca gccagtcatt actcttgttt gttctcacct gggtgcgcac     6900

cctcatgatg cagtggctgt agcaccttca tgccaggtgc tgagagaatg ggaaattctt     6960

cctccccatt gacctgagtc ccagagactt agggacacag acttcaggtg aggctgcgga     7020

cctcagaagc agtggataat agattggggc attaaaagct tttgaggcag ggggctcatg     7080

ttttgactgc agggagttat gctgagcaaa gagatgtgtt tttcaaaacc agggttcaaa     7140

accagtgtcc acgctggagt aagtggagca tgcttctctg tgttctctga atgatcttgc     7200

actcctctta agcaaaggag taccatgacc atagtcagtg ggatcccaca aatgttctta     7260

aatgggtaag gctttaagta gccagagagt atccagccta ccattggctt ctccacatcc     7320

taaaacctga gacagccttg gtatatgctt tataaatgtt tcttttcttg ttgtttaagt     7380

aattaaagtg tttaaaatgt cttcattaga tgtgacgatt gtttaatgag tttgcctctg     7440

acgtgtggct ccatgggaga taggcaaagt aattaagaag ttaccagaaa ttggtcggct     7500

ggggaaatgc aaaagttagc atttcagtag tgaatttctc ctggaacaaa tgagcaattt     7560

ttcctctttc tcttaagtag tatacccttt tctcacttag taatttaatg gtatataaag     7620

acatgtgtat aagtgagtgc atacatatga ggtatgacta tagggttgtt tgtgggaatt     7680

tcttttccta acatacagaa gatcaaagtg ttcatctcac cccgccctcc ttaaaaggtg     7740

tcttttggga gactatgtgc tcattgacta tagtgctgcc aagtaaaaat atcttgggaa     7800

ctcttctact agaatggcct tcagggcttg gcatgttcct ttggtttacc cttagagatg     7860

agaaatcctc ctcctttgag gatggattta agttctggaa ataatctcaa gtgcttgata     7920

gcacagttgg atgaaaaaag atggcaatta aggtaagtta caccattttt gtttctaaaa     7980

aaatccctaa gaaatttctt ggaatgagtc tttggcctca gagcctctca aagtgtccac     8040

ttcaaggggg gatcatcctc attagcacac agatttttaa aaatcaattc tcttgccatg     8100

cctcctatgt gttcacatct ctgcatacac tacagatata agtgcataat cattcatata     8160

aacatctggt aggtattctg taaaactgtg tttactttag tgcatgttat tgtcatgtta     8220

tgatgtgact ggggtgtttc tttgtcatga aactttgctt cttcacagaa ttagaatact     8280

gctctctcta tattgaacta catatacagc gttttcttgt atcagccccc aaagtctgga     8340

tgcccggtgt tgtgtttaca tgtgattgtg cctaggagtc tgttcacata gagacacctg     8400

taagtattta ttacaaaacg gaatgtaagc aaatatatcc acattggttt tatttgaatc     8460

aaggtgtttt tttgtttttt gttttttttc cttttgagga ggaacaggga gcctcctcct     8520

ccatgagcac ttacagaatt gtgtaaaatt ctgtgaaaca gtggtaagca tgggcacccg     8580

atttcagctg tcctgctgcc gctgccctcc aacctgctct gtgtgtgtgt gtcgctgtgc     8640

ttggtggcag tgtgccgtgc tcgtgccggc tcttcccagc agactggtat ctggctgtaa     8700

cgtttgacgt cttcatattg ccagtctgta ttgaggggtg atgtacatgg ccatacagcc     8760

aaatgggtct gtgtaccagt gtggggattc caagaacact gcctgtcccc cacagcaaat     8820

attgatgctg ttggtcagcc aaagattttc ctctcctttg ctgcttaaac ttgtgcctta     8880

atattgtaca taataaatgg ataaaatggc aaaatgactc ttttctctcg cttgctcctt     8940

tcttccttaa agaacttata aactgatgct caataaatgt ttcatttcat tgtacccca      8999


<210>  15
<211>  8127
<212>  DNA
<213>  rattus norvegicus


<220>
<221>  misc_feature
<223>  rat Amotl1 cDNA

<220>
<221>  misc_feature
<222>  (554)..(555)
<223>  n is a, c, g, or t

<400>  15
gatctctgcc ccgacatgca ggcgtttgat gagagctgca tgcacgaggg gctaggtgga       60

agcatggatc tcagtggaaa ctggactctg gaggacggaa gctggctgtc acccactggg      120

gatcgccact tccccaacgg cagaggcgag agtgattttg tggacaccac tcccgcatct      180

ttcagcccgg aggagttagc tcctcccccc atctgctaca gccccggcag tcctgcgcag      240

attctagaag accacgccta cttctaccca gacttgcagc tctattctgg gaggcatgaa      300

gcacctactt tgacagtgga ggcaaacgga ggcctgaggg ggaaaagcgg taagtcctct      360

tgctgttgga gtgcacgttg ggagcccaga gggtcggcgt ttctcatttt cacctcttct      420

acattaagaa acccctgtgc ccgtgacttt agtttccacc actttcacac aatggtttcg      480

atgacaatcc ggaaactcta caagggacag gggccgtcga gcacacttta ctacatgttc      540

cgcgaggtac tggnnagtca gaagtcccgc accgagggga ggcccaccgt gaaccgggcc      600

aacagcggac aagcacataa ggatgaggcc ctaaaagaac taaagcaggg ccatgtccgg      660

tccctcagtg agaggatcat gcagctgtcg ctggagagga atggaactaa gcaacacctc      720

cccagctcgg gaaatggaaa gagcttcaaa gctggaggag agccatctcc tgcccagccc      780

gtctgtaaag cactggaccc tcgtggccct ccacctgaat accccttcaa gaccaagcca      840

atgaaatccc cagtcagcaa gaaccaagat cacggtcttt actacagtga ccagcaccct      900

ggggtactcc acgagatggt caaaccttac ccagcacctc agcctgcgag aacagaagtg      960

gccgtcctga ggtaccagcc acccccagag tatggcgtca ccagtcgccc ctgccagctg     1020

ccttttccct ccacggtgca gcagcatagc cccatgtcct ctcagacttc ctccatcagt     1080

ggtcctctgc actcggtctc cctgcctctt ccacttccca tgagcctggc ggctccacag     1140

cccccaccgg cctcccccag ccagcagctc ggaccagatg ccttcgcgat tgtggagaga     1200

gcccaacaaa tggtagagat cctcacagag gagaaccgtg tgcttcacca ggagcttcag     1260

ggctgctatg acaacgccga caagctccac aagtttgaaa aagagctgca gagtatctca     1320

gaggcctatg agagcctggt caagtccacc accaagcgtg agtccctgga caaggcaatg     1380

agaaacaagc tcgaaggcga gataaggagg cttcatgact tcaacagaga tctccgagat     1440

cgactggaga cagccaacag gcagctgtcc agcagggaat atgaagggca cgaagacaaa     1500

gctgcagaga gccatcacat gtcccagaat aaagaattct tgaaggagaa ggagaagttg     1560

gaaatggagc tggcagcagt gcggacggcg agcgaggacc accggaggca tattgagatc     1620

ctggaccaag ctttgagcaa tgcccaggcc agagtgatca agctggagga agagttacga     1680

gagaagcaag cctatgtgga gaaggtggag aagctgcagc aggccctgac ccagctgcag     1740

tctgcgtgtg agaagcgagg gcagatggag cgcaggttgc ggacctggct ggagagggag     1800

ctggatgctc tgaggacaca gcagaaacat gggaatggcc agcccgtcaa tctcccggaa     1860

tataatgctc ctgccctcat ggagcttgtg cgggagaagg aggagcggat tctagccctg     1920

gaggccgaca tgaccaaatg ggagcagaag tacctggaag agagcaccat ccgacacttt     1980

gccatgagcg ccgccgccgc tgccacggcc gagagggaca ctaccatcag caaccactca     2040

aggaatggca gctatggtga gagctccctg gaggcccaca tctggccaga ggaagaggag     2100

gtggtgcagg ccaacaggcg gtgtcaggac atggagtaca ctattaaaaa cctccatgcc     2160

aaaatcatag agaaggatgc catgataaaa gtcctgcagc agcgatcccg taaggatgct     2220

gggaagactg actcttccag tctgcggcct gcccgctctg tcccatccat tgctgcggcc     2280

accgggacac attcccgtca gacttcactg accagcggcc agctggcaga agacaagaag     2340

gaagagaaga cctggaaggg gagtatagga ttcctgctgg ggaaggagca ccagggacag     2400

gcttctgccc ctctgctgcc agccacacct gcctctgcac tgtccccgcc gacctccacc     2460

acatcagcca gcagcaccca cgccaagaca ggcagcaagg acagcagcac gcagaccgac     2520

aagatcactg agctcttctg gcccagcatg gcttccctcc cgagccgcgg caggctcagc     2580

accgcccctt ccaacagccc cgtcctgaaa catccagctg ccaaaggaac cgtggagaaa     2640

caggagaact ctcctgggca cgggaagtca tcagaacaca gaggccgagt cagcagcttg     2700

ttgcagaagc ctgagttccc ggatggagag ataatggaag tgctcatcta accgtcgtcc     2760

tgtggagtgt ggtgccagca tgctgacaga cgcactagag gctgcaagaa gagagaagat     2820

ccagatggtc agttgcagta gcaactgcaa aaccaggaca gctgtggaca ccgtgtcaca     2880

gtgttaccaa cgcagctggc tcgtgtcaca gtgttaccaa cgcagctggc tcgtgtcaca     2940

gtgttaccaa cgcagctggc tcacttgtct gcagagggag tgaaagagaa cgcatgcagg     3000

ctgagaagca gagttgagga ggagtggaat tttccattgt agagaaattg tatgttttgg     3060

ggaggttcca tgcttccccg ttcttggctg ataaacagat gaagaaaagc cagcctttcc     3120

ttggaatgac cttcttccct ttgtctctta gcaggtttgg tttaagaaga atcttggcat     3180

aatgtagtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt     3240

gtccttagca gatacatcca ggataatggg ggattccaca ggcaagtttt gtcaccttct     3300

tggctgtttt catttgtggt ttgtggtttc agagagtgtg aggctttgct tgtctggatt     3360

gaatggtatt ttctgagcag gatgggagag agatgccctt ggccctcatc cgccctgact     3420

tctttgaact tatctgtctt gtctctactt attattttgt tgtaattttt ttctgtttaa     3480

ttagacatag cagagttcct tacgtatggg acttaggaga ctaccatcca tgctgtggtg     3540

tccaattgga cagagcctcc tgttgacacc ccggctgctt ccccacacct ctgcttagcc     3600

aaactgcagc tgtcaatctt actgtgagct agggaaactt ggatgaggag tccatgagtc     3660

gatagatagg gtaacatcgt gccctgatgt gcctctcatt cacatccgct ctcttgcaag     3720

gaacttgaca gtcacacccc aatgccctgt aggaaggctt ccttgtgagc aggcaccaca     3780

ggaaccccat gatggcttat gcagagctct ctgggtggct gcgagatctc acaggcatcc     3840

cccagccact ttctgtatcg gaagctctca gttctgttca ttgctccctc tggcctcctt     3900

ctgccctggc tcctgttgat gagcacagtg ccgtccctga tcagttcttt cttcctgtga     3960

atttgcttcg tagcccatca ggctggtaga ctggcagcac ggtcagtgtc acccgaggga     4020

caggacttcc ctgaagtgaa gcagcaatgt catggaagcg aacccctgtg agcgagagac     4080

aggccccgag gctgctgcca caaggtctca tgttcattgc tggggacact agcttcctac     4140

aaaccccagg agacgctgcc catagcacgg gtggcccttc aggctcctga actatctatc     4200

cccagatcag taggatttgt tttccaagtc cccttcctca ttccttcttt gctcaagaga     4260

aaaaagaaaa gtggtaactc tgtgactcta agtccctctt aaatgcagcg ctgaatctag     4320

cttggctcgg agatctctga cttgtcccta gggtgagact gtggcctccc caggttgagg     4380

tggcacgtgt attgtgagag attagcctgg agagcagaga agagggggag gggggatagg     4440

gaggagagag caatcgtgtc tccctacagg accctgggcc atctgacaag acagaggagg     4500

tgggactggc ttccccatgc tgcacatggc agtgggaacc aggcttggag tcccccaccc     4560

cctccttaac ctcttctctc agaccttgta gccctagctt gccctgtgct ctgcagggaa     4620

ggggatgaga ggacagcata agaagtcttg ccagttgagg tggggctgga agatgaagca     4680

ggtgggtgta ggaatcattt tggatagggc atgttgtttg gttgacggca actaattctc     4740

ttaagagcat attgtctcca gttaatgttg gagacaaccc agaaagggaa gggtatagag     4800

atgggtaatt aatgagatat tccagccctg gagcaatgtc tgagccaccc caaacttagg     4860

ctgtctccca gcataggagt ggggcactgc cccttactca aattctagtc taagtgttcc     4920

agacacattg tacacttgga caggaaatct cctgttccag cataccctct cccccatacc     4980

ctctccccca taccccctcc cccatacctt ctcccccata ctgttagtac gtttcagttg     5040

ttcaaaagca aagggggcgc agactaggct ttaactgcat gtggagtgta gattttgcct     5100

aagaatccat gttgaagaag agagaggcta tgtctttaag gtcgaggccc ttcagtcttc     5160

tgtccttgta attctcttga agcgtgagcc ccaggcactc agaagccatg ttgtactccg     5220

ggaagttcat gggacctgaa ctccttcaac accgggaaca acagtactgc ataggtactt     5280

tggtactgac tgtgcaagca ctagaaaaag tacccgttga atggccctca cagcatcagg     5340

gaaacgaggc cgagttcact ctcctgattg ctcagatgca gaagctggac ccgtgaggtg     5400

taccagccca cctccaagct tgacacagag gctagcactt aaagcaaaga ctcagaagag     5460

gagtctcagt cacaggctgc acagccttga acatgatatc tagaactatg cctgggtgat     5520

cggtggccca acttgtgaca cttgtgtgca catagggaag ctgacgctcc tctcggggcc     5580

tgaaaacagg actaaaccca aaccccatat aactaaccat accactgcca tccacaggcg     5640

tggatggaag tcttcacggt ctgttacaag cacaagtaca aagccgataa aaataagtca     5700

aagcccttcc tcgtggtgca gagggctcct cctcagatct cttggagcct ttgatcatag     5760

agcttgacgg tctcctctcg ggataaagga caggtaaagg ctgtggcctt cagcggtgac     5820

tgccccacac cctgctttcc ttaggggtgg agacaaggaa tggtggggcc agtgttgttc     5880

agagagaagt ctctctttgg agcccatgta tggggcttga ccttttgctg tgagtgcatt     5940

tagaggcaag tgaattctgg cctcagtaca gagaacccag cggtttcagc actcaagaaa     6000

gaagccgcag tgtcccctac agagaggctc tgtcctgctt ggccccagcc acctgcgcca     6060

cacatttaat aaagtggctg aaactcctcc tttccaagag ctagtgtgct gggtcctgtc     6120

ctccccacag ccttctgagt cccagagact tgtgtgagca gtcggataag gccaatctgg     6180

gagacagggg atgaccatga cacaaggtgt ttccaggcag gtcccttgtg cgtaggctgc     6240

agaaagctgt cctgactggg agcttgggtt gtacgaacac atggtgcctt ctttgtctgt     6300

gctgaacgag tagggtgtgt ttctctgtgt tctctgagta agatcacacc ctctttaagc     6360

aaaggggtgt tgtggatatt agaagcaaga ttgataaatg ttcttaaatg gtggtgctag     6420

agaaaagtca gtccccgtaa cttcctaaaa gctgagtcag ccagtctcta agtatgtaca     6480

tgttggcttt cttctatttt ttttctagtt aatcagtgtg ttttaaatgt ttttagttga     6540

tgtgaggatt tttttaaagg catttgtgtg tggtgtggct ccatgggaga taggctgtgt     6600

aataagaacc ctcagaagcc agccagtcat ccaaggggcg cccaagttca gtggatttct     6660

tcaggaattg gagagcagta tttttccctc ttttcagtag tatgcctgtt ctcatttagt     6720

aatttaatgg tatattgcat tatatgtgaa tgcatacata aacggtggaa tttctcttaa     6780

tatccaaaaa agtccttctg ttgccctctg agctctctcc ttggggagga ctgcagggct     6840

cactgtgtaa aatggttgtg gactcctcta gcagaatggc ttccaaggcc tggcccattc     6900

ctcagattcc ctttgaagtg agaggtcatt gtcttttgag aatggattta agttttggaa     6960

ataccccacg ctgttcacag tgcaagcgac tgaacacaga acaattagtc agaatcagaa     7020

tcccagggcc atcaagatga ctccacggaa aagggactgc caccaaccag agccaagacc     7080

tgagtttggt ccccaggaac cccatggcag caggagagag tcagccgatg caagtgtcac     7140

acacacacat aaacacacac atacacatgc aacacataca cacaaacaca tacatacaca     7200

cacacaaaca catacacaca tgcacacaca cacacacaca cacacacaca cacacagagt     7260

ttttggaaga atatctatga tgtaggaaaa ggtttgttag tacctgcaac ctctagggcc     7320

tcatttccaa gcctgctgct tctcttgcca ggacttatac gtgtgcaacc cctgcgtaca     7380

ctacagacct aagtacatac tcgctaacat gaacacccag taggtattct gtaaaacgga     7440

tatacttaag tgcatgttat tgtcgtgtgt gccgcgactg agctgtgtct ttgtcatgaa     7500

actttgcttc tttgccaaat taagactctg ccctccctcc gaggaaggaa atatacagca     7560

gtttctggaa tcagcttctc aagttttccc gcctgtgttg tgtttacttg tggctttgcc     7620

tgagagtctg tcctcacgta cacacctgtg agtatttatt acaaggcaga acggggacag     7680

gcgtagccat agtacttgtg tttgaatgtt tccagggagg gacaatggag ccccctcctc     7740

agtgaggtgc tcacagaatc tgtgtcaaat tctgtgaacg gggtccaaca ctagtaccag     7800

cttcacccca accctgagtg ccctggagcc actgccctct ctactgcctt gtgtgtgcat     7860

gggtgtggtt gtgtgtgtgt ctctgttggg gcatgtgccg catttcgcag tggactttgg     7920

tatccacatg taacctttgg catctgtgtt cctggaccgc attgacagat ctgtggtgtg     7980

cagatctgtg tagatgggtc tgtgtgcaaa gtggggagtc ccctgaaagt gactatggat     8040

attgttggtc agccaaagac tttcctattc tttgctgctt aaactttgtg ccttaatatt     8100

gtaaatataa acggttaaaa caagcaa                                         8127


<210>  16
<211>  968
<212>  PRT
<213>  mus musculus


<220>
<221>  MISC_FEATURE
<223>  mouse Amotl1 polypeptide

<400>  16

Met Arg Arg Ala Lys Ser Arg Arg Gly Pro Cys Glu Pro Val Leu Arg 
1               5                   10                  15      


Ala Pro Pro Pro Ile Cys Tyr Ser Pro Ser Ser Pro Val Gln Ile Leu 
            20                  25                  30          


Glu Asp Pro Ala Tyr Phe Tyr Pro Asp Leu Gln Leu Tyr Ser Gly Arg 
        35                  40                  45              


His Glu Ala Ser Thr Leu Thr Val Glu Ala Ser Gly Gly Leu Arg Gly 
    50                  55                  60                  


Lys Ser Val Glu Asp Pro Leu Ser Ser Phe His Ser Pro Asn Phe Leu 
65                  70                  75                  80  


Arg Thr Pro Glu Val Glu Met Arg Gly Ser Glu Asp Val Ala Ser Gly 
                85                  90                  95      


Arg Val Leu Gln Arg Leu Ile Gln Glu Gln Leu Arg Tyr Gly Thr Pro 
            100                 105                 110         


Thr Glu Asn Met Asn Leu Leu Ala Ile Gln His Gln Ala Thr Gly Ser 
        115                 120                 125             


Ala Gly Pro Ala His Ala Thr Thr Asn Phe Ser Ser Thr Glu Thr Leu 
    130                 135                 140                 


Thr Gln Glu Asp Pro Gln Met Val Tyr Gln Ser Ala Arg Gln Glu Pro 
145                 150                 155                 160 


Gln Gly Gln Glu His Gln Gly Asp Asn Thr Val Met Glu Lys Gln Val 
                165                 170                 175     


Arg Ser Thr Gln Pro Gln Gln Asn Asn Glu Glu Leu Pro Thr Tyr Glu 
            180                 185                 190         


Glu Ala Lys Ala Gln Ser Gln Phe Phe Arg Gly Gln Gln Gln Gln Gln 
        195                 200                 205             


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gly Gln Gly 
    210                 215                 220                 


Pro Leu Ser His Thr Tyr Tyr Met Ala Gly Gly Thr Ser Gln Lys Ser 
225                 230                 235                 240 


Arg Thr Glu Gly Arg Pro Thr Val Asn Arg Ala Asn Ser Gly Gln Ala 
                245                 250                 255     


His Lys Asp Glu Ala Leu Lys Glu Leu Lys Gln Gly His Val Arg Ser 
            260                 265                 270         


Leu Ser Glu Arg Ile Met Gln Leu Ser Leu Glu Arg Asn Gly Ala Lys 
        275                 280                 285             


Gln His Leu Pro Ser Ser Gly Asn Gly Lys Ser Phe Lys Ala Gly Gly 
    290                 295                 300                 


Glu Pro Ser Pro Ala Gln Pro Val Cys Lys Ala Leu Asp Pro Arg Gly 
305                 310                 315                 320 


Pro Pro Pro Glu Tyr Pro Phe Lys Thr Lys Pro Met Lys Ser Pro Val 
                325                 330                 335     


Ser Lys Asn Gln Asp His Gly Leu Tyr Tyr Asn Asp Gln His Pro Gly 
            340                 345                 350         


Val Leu His Glu Met Val Lys Pro Tyr Pro Ala Pro Gln Pro Ala Arg 
        355                 360                 365             


Thr Glu Val Ala Val Leu Arg Tyr Gln Pro Pro Pro Glu Tyr Gly Val 
    370                 375                 380                 


Thr Ser Arg Pro Cys Gln Leu Pro Phe Pro Ser Thr Val Gln Gln His 
385                 390                 395                 400 


Ser Pro Met Ser Ser Gln Thr Ser Ser Ile Gly Gly Thr Leu His Ser 
                405                 410                 415     


Val Ser Leu Pro Leu Pro Leu Pro Ile Ser Leu Ala Ala Ser Gln Pro 
            420                 425                 430         


Leu Pro Ala Ser Pro Asn Gln Gln Leu Gly Pro Asp Ala Phe Ala Ile 
        435                 440                 445             


Val Glu Arg Ala Gln Gln Met Val Glu Ile Leu Thr Glu Glu Asn Arg 
    450                 455                 460                 


Val Leu His Gln Glu Leu Gln Gly Cys Tyr Asp Asn Ala Asp Lys Leu 
465                 470                 475                 480 


His Lys Phe Glu Lys Glu Leu Gln Ser Ile Ser Glu Ala Tyr Glu Ser 
                485                 490                 495     


Leu Val Lys Ser Thr Thr Lys Arg Glu Ser Leu Asp Lys Ala Met Arg 
            500                 505                 510         


Thr Lys Leu Glu Gly Glu Ile Arg Arg Leu His Asp Phe Asn Arg Asp 
        515                 520                 525             


Leu Arg Asp Arg Leu Glu Thr Ala Asn Arg Gln Leu Ser Ser Arg Glu 
    530                 535                 540                 


Tyr Asp Gly His Glu Asp Lys Ala Ala Glu Ser His Tyr Val Ser Gln 
545                 550                 555                 560 


Asn Lys Glu Phe Leu Lys Glu Lys Glu Lys Leu Glu Met Glu Leu Ala 
                565                 570                 575     


Ala Val Arg Thr Ala Ser Glu Asp His Arg Arg His Ile Glu Ile Leu 
            580                 585                 590         


Asp Gln Ala Leu Ser Asn Ala Gln Ala Arg Val Ile Lys Leu Glu Glu 
        595                 600                 605             


Glu Leu Arg Glu Lys Gln Ala Tyr Val Glu Lys Val Glu Lys Leu Gln 
    610                 615                 620                 


Gln Ala Leu Thr Gln Leu Gln Ser Ala Cys Glu Lys Arg Gly Gln Met 
625                 630                 635                 640 


Glu Arg Arg Leu Arg Thr Trp Leu Glu Arg Glu Leu Asp Ala Leu Arg 
                645                 650                 655     


Thr Gln Gln Lys His Gly Thr Gly Pro Pro Val Ser Leu Pro Glu Cys 
            660                 665                 670         


Asn Ala Pro Ala Leu Met Glu Leu Val Arg Glu Lys Glu Glu Arg Ile 
        675                 680                 685             


Leu Ala Leu Glu Ala Asp Met Thr Lys Trp Glu Gln Lys Tyr Leu Glu 
    690                 695                 700                 


Glu Ser Thr Ile Arg His Phe Ala Met Ser Ala Ala Ala Ala Ala Thr 
705                 710                 715                 720 


Ala Glu Arg Asp Thr Thr Ile Ser Asn His Ser Arg Asn Gly Ser Tyr 
                725                 730                 735     


Gly Glu Ser Ser Leu Glu Ala His Ile Trp Pro Glu Glu Glu Glu Val 
            740                 745                 750         


Val Gln Ala Asn Arg Arg Cys Gln Asp Met Glu Tyr Thr Ile Lys Asn 
        755                 760                 765             


Leu His Ala Lys Ile Ile Glu Lys Asp Ala Met Ile Lys Val Leu Gln 
    770                 775                 780                 


Gln Arg Ser Arg Lys Asp Ala Gly Lys Thr Asp Ser Ala Ser Leu Arg 
785                 790                 795                 800 


Pro Ala Arg Ser Val Pro Ser Ile Ala Ala Ala Thr Gly Thr His Ser 
                805                 810                 815     


Arg Gln Thr Ser Leu Thr Ser Ser Gln Leu Thr Glu Glu Lys Lys Glu 
            820                 825                 830         


Glu Lys Thr Thr Trp Lys Gly Ser Ile Gly Phe Leu Leu Gly Lys Glu 
        835                 840                 845             


His Gln Gly Gln Ala Ser Ala Pro Leu Leu Pro Thr Thr Pro Ala Ser 
    850                 855                 860                 


Ala Leu Ser Leu Pro Ala Ser Thr Thr Ser Ala Ser Ser Thr His Ala 
865                 870                 875                 880 


Lys Thr Gly Ser Lys Asp Ser Ser Thr Gln Thr Asp Lys Ser Thr Glu 
                885                 890                 895     


Leu Phe Trp Pro Ser Met Ala Ser Leu Pro Ser Arg Gly Arg Leu Ser 
            900                 905                 910         


Thr Ala Pro Ser Asn Ser Pro Ile Leu Lys His Pro Ala Ala Lys Gly 
        915                 920                 925             


Ala Val Glu Lys Gln Glu Asn Ser Pro Gly His Gly Lys Ala Ser Glu 
    930                 935                 940                 


His Arg Gly Arg Val Ser Asn Leu Leu His Lys Pro Glu Phe Pro Asp 
945                 950                 955                 960 


Gly Glu Met Met Glu Val Leu Ile 
                965             


<210>  17
<211>  956
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  human Amotl1 polypeptide

<400>  17

Met Trp Arg Ala Lys Leu Arg Arg Gly Thr Cys Glu Pro Ala Val Lys 
1               5                   10                  15      


Gly Ser Pro Ser Ala Cys Tyr Ser Pro Ser Ser Pro Val Gln Val Leu 
            20                  25                  30          


Glu Asp Ser Thr Tyr Phe Ser Pro Asp Phe Gln Leu Tyr Ser Gly Arg 
        35                  40                  45              


His Glu Thr Ser Ala Leu Thr Val Glu Ala Thr Ser Ser Ile Arg Glu 
    50                  55                  60                  


Lys Val Val Glu Asp Pro Leu Cys Asn Phe His Ser Pro Asn Phe Leu 
65                  70                  75                  80  


Arg Ile Ser Glu Val Glu Met Arg Gly Ser Glu Asp Ala Ala Ala Gly 
                85                  90                  95      


Thr Val Leu Gln Arg Leu Ile Gln Glu Gln Leu Arg Tyr Gly Thr Pro 
            100                 105                 110         


Thr Glu Asn Met Asn Leu Leu Ala Ile Gln His Gln Ala Thr Gly Ser 
        115                 120                 125             


Ala Gly Pro Ala His Pro Thr Asn Asn Phe Ser Ser Thr Glu Asn Leu 
    130                 135                 140                 


Thr Gln Glu Asp Pro Gln Met Val Tyr Gln Ser Ala Arg Gln Glu Pro 
145                 150                 155                 160 


Gln Gly Gln Glu His Gln Val Asp Asn Thr Val Met Glu Lys Gln Val 
                165                 170                 175     


Arg Ser Thr Gln Pro Gln Gln Asn Asn Glu Glu Leu Pro Thr Tyr Glu 
            180                 185                 190         


Glu Ala Lys Ala Gln Ser Gln Phe Phe Arg Gly Gln Gln Gln Gln Gln 
        195                 200                 205             


Gln Gln Gln Gly Ala Val Gly His Gly Tyr Tyr Met Ala Gly Gly Thr 
    210                 215                 220                 


Ser Gln Lys Ser Arg Thr Glu Gly Arg Pro Thr Val Asn Arg Ala Asn 
225                 230                 235                 240 


Ser Gly Gln Ala His Lys Asp Glu Ala Leu Lys Glu Leu Lys Gln Gly 
                245                 250                 255     


His Val Arg Ser Leu Ser Glu Arg Ile Met Gln Leu Ser Leu Glu Arg 
            260                 265                 270         


Asn Gly Ala Lys Gln His Leu Pro Gly Ser Gly Asn Gly Lys Gly Phe 
        275                 280                 285             


Lys Val Gly Gly Gly Pro Ser Pro Ala Gln Pro Ala Gly Lys Val Leu 
    290                 295                 300                 


Asp Pro Arg Gly Pro Pro Pro Glu Tyr Pro Phe Lys Thr Lys Gln Met 
305                 310                 315                 320 


Met Ser Pro Val Ser Lys Thr Gln Glu His Gly Leu Phe Tyr Gly Asp 
                325                 330                 335     


Gln His Pro Gly Met Leu His Glu Met Val Lys Pro Tyr Pro Ala Pro 
            340                 345                 350         


Gln Pro Val Arg Thr Asp Val Ala Val Leu Arg Tyr Gln Pro Pro Pro 
        355                 360                 365             


Glu Tyr Gly Val Thr Ser Arg Pro Cys Gln Leu Pro Phe Pro Ser Thr 
    370                 375                 380                 


Met Gln Gln His Ser Pro Met Ser Ser Gln Thr Ser Ser Ala Ser Gly 
385                 390                 395                 400 


Pro Leu His Ser Val Ser Leu Pro Leu Pro Leu Pro Met Ala Leu Gly 
                405                 410                 415     


Ala Pro Gln Pro Pro Pro Ala Ala Ser Pro Ser Gln Gln Leu Gly Pro 
            420                 425                 430         


Asp Ala Phe Ala Ile Val Glu Arg Ala Gln Gln Met Val Glu Ile Leu 
        435                 440                 445             


Thr Glu Glu Asn Arg Val Leu His Gln Glu Leu Gln Gly Tyr Tyr Asp 
    450                 455                 460                 


Asn Ala Asp Lys Leu His Lys Phe Glu Lys Glu Leu Gln Arg Ile Ser 
465                 470                 475                 480 


Glu Ala Tyr Glu Ser Leu Val Lys Ser Thr Thr Lys Arg Glu Ser Leu 
                485                 490                 495     


Asp Lys Ala Met Arg Asn Lys Leu Glu Gly Glu Ile Arg Arg Leu His 
            500                 505                 510         


Asp Phe Asn Arg Asp Leu Arg Asp Arg Leu Glu Thr Ala Asn Arg Gln 
        515                 520                 525             


Leu Ser Ser Arg Glu Tyr Glu Gly His Glu Asp Lys Ala Ala Glu Gly 
    530                 535                 540                 


His Tyr Ala Ser Gln Asn Lys Glu Phe Leu Lys Glu Lys Glu Lys Leu 
545                 550                 555                 560 


Glu Met Glu Leu Ala Ala Val Arg Thr Ala Ser Glu Asp His Arg Arg 
                565                 570                 575     


His Ile Glu Ile Leu Asp Gln Ala Leu Ser Asn Ala Gln Ala Arg Val 
            580                 585                 590         


Ile Lys Leu Glu Glu Glu Leu Arg Glu Lys Gln Ala Tyr Val Glu Lys 
        595                 600                 605             


Val Glu Lys Leu Gln Gln Ala Leu Thr Gln Leu Gln Ser Ala Cys Glu 
    610                 615                 620                 


Lys Arg Glu Gln Met Glu Arg Arg Leu Arg Thr Trp Leu Glu Arg Glu 
625                 630                 635                 640 


Leu Asp Ala Leu Arg Thr Gln Gln Lys His Gly Asn Gly Gln Pro Ala 
                645                 650                 655     


Asn Met Pro Glu Tyr Asn Ala Pro Ala Leu Leu Glu Leu Val Arg Glu 
            660                 665                 670         


Lys Glu Glu Arg Ile Leu Ala Leu Glu Ala Asp Met Thr Lys Trp Glu 
        675                 680                 685             


Gln Lys Tyr Leu Glu Glu Ser Thr Ile Arg His Phe Ala Met Asn Ala 
    690                 695                 700                 


Ala Ala Thr Ala Ala Ala Glu Arg Asp Thr Thr Ile Ile Asn His Ser 
705                 710                 715                 720 


Arg Asn Gly Ser Tyr Gly Glu Ser Ser Leu Glu Ala His Ile Trp Gln 
                725                 730                 735     


Glu Glu Glu Glu Val Val Gln Ala Asn Arg Arg Cys Gln Asp Met Glu 
            740                 745                 750         


Tyr Thr Ile Lys Asn Leu His Ala Lys Ile Ile Glu Lys Asp Ala Met 
        755                 760                 765             


Ile Lys Val Leu Gln Gln Arg Ser Arg Lys Asp Ala Gly Lys Thr Asp 
    770                 775                 780                 


Ser Ser Ser Leu Arg Pro Ala Arg Ser Val Pro Ser Ile Ala Ala Ala 
785                 790                 795                 800 


Thr Gly Thr His Ser Arg Gln Thr Ser Leu Thr Ser Ser Gln Leu Ala 
                805                 810                 815     


Glu Glu Lys Lys Glu Glu Lys Thr Trp Lys Gly Ser Ile Gly Leu Leu 
            820                 825                 830         


Leu Gly Lys Glu His His Glu His Ala Ser Ala Pro Leu Leu Pro Pro 
        835                 840                 845             


Pro Pro Thr Ser Ala Leu Ser Ser Ile Ala Ser Thr Thr Ala Ala Ser 
    850                 855                 860                 


Ser Ala His Ala Lys Thr Gly Ser Lys Asp Ser Ser Thr Gln Thr Asp 
865                 870                 875                 880 


Lys Ser Ala Glu Leu Phe Trp Pro Ser Met Ala Ser Leu Pro Ser Arg 
                885                 890                 895     


Gly Arg Leu Ser Thr Thr Pro Ala His Ser Pro Val Leu Lys His Pro 
            900                 905                 910         


Ala Ala Lys Gly Thr Ala Glu Lys Leu Glu Asn Ser Pro Gly His Gly 
        915                 920                 925             


Lys Ser Pro Asp His Arg Gly Arg Val Ser Ser Leu Leu His Lys Pro 
    930                 935                 940                 


Glu Phe Pro Asp Gly Glu Met Met Glu Val Leu Ile 
945                 950                 955     


<210>  18
<211>  911
<212>  PRT
<213>  rattus norvegicus


<220>
<221>  MISC_FEATURE
<223>  rat Amotl1 polypeptide

<220>
<221>  misc_feature
<222>  (180)..(180)
<223>  Xaa can be any naturally occurring amino acid

<400>  18

Met Gln Ala Phe Asp Glu Ser Cys Met His Glu Gly Leu Gly Gly Ser 
1               5                   10                  15      


Met Asp Leu Ser Gly Asn Trp Thr Leu Glu Asp Gly Ser Trp Leu Ser 
            20                  25                  30          


Pro Thr Gly Asp Arg His Phe Pro Asn Gly Arg Gly Glu Ser Asp Phe 
        35                  40                  45              


Val Asp Thr Thr Pro Ala Ser Phe Ser Pro Glu Glu Leu Ala Pro Pro 
    50                  55                  60                  


Pro Ile Cys Tyr Ser Pro Gly Ser Pro Ala Gln Ile Leu Glu Asp His 
65                  70                  75                  80  


Ala Tyr Phe Tyr Pro Asp Leu Gln Leu Tyr Ser Gly Arg His Glu Ala 
                85                  90                  95      


Pro Thr Leu Thr Val Glu Ala Asn Gly Gly Leu Arg Gly Lys Ser Gly 
            100                 105                 110         


Lys Ser Ser Cys Cys Trp Ser Ala Arg Trp Glu Pro Arg Gly Ser Ala 
        115                 120                 125             


Phe Leu Ile Phe Thr Ser Ser Thr Leu Arg Asn Pro Cys Ala Arg Asp 
    130                 135                 140                 


Phe Ser Phe His His Phe His Thr Met Val Ser Met Thr Ile Arg Lys 
145                 150                 155                 160 


Leu Tyr Lys Gly Gln Gly Pro Ser Ser Thr Leu Tyr Tyr Met Phe Arg 
                165                 170                 175     


Glu Val Leu Xaa Ser Gln Lys Ser Arg Thr Glu Gly Arg Pro Thr Val 
            180                 185                 190         


Asn Arg Ala Asn Ser Gly Gln Ala His Lys Asp Glu Ala Leu Lys Glu 
        195                 200                 205             


Leu Lys Gln Gly His Val Arg Ser Leu Ser Glu Arg Ile Met Gln Leu 
    210                 215                 220                 


Ser Leu Glu Arg Asn Gly Thr Lys Gln His Leu Pro Ser Ser Gly Asn 
225                 230                 235                 240 


Gly Lys Ser Phe Lys Ala Gly Gly Glu Pro Ser Pro Ala Gln Pro Val 
                245                 250                 255     


Cys Lys Ala Leu Asp Pro Arg Gly Pro Pro Pro Glu Tyr Pro Phe Lys 
            260                 265                 270         


Thr Lys Pro Met Lys Ser Pro Val Ser Lys Asn Gln Asp His Gly Leu 
        275                 280                 285             


Tyr Tyr Ser Asp Gln His Pro Gly Val Leu His Glu Met Val Lys Pro 
    290                 295                 300                 


Tyr Pro Ala Pro Gln Pro Ala Arg Thr Glu Val Ala Val Leu Arg Tyr 
305                 310                 315                 320 


Gln Pro Pro Pro Glu Tyr Gly Val Thr Ser Arg Pro Cys Gln Leu Pro 
                325                 330                 335     


Phe Pro Ser Thr Val Gln Gln His Ser Pro Met Ser Ser Gln Thr Ser 
            340                 345                 350         


Ser Ile Ser Gly Pro Leu His Ser Val Ser Leu Pro Leu Pro Leu Pro 
        355                 360                 365             


Met Ser Leu Ala Ala Pro Gln Pro Pro Pro Ala Ser Pro Ser Gln Gln 
    370                 375                 380                 


Leu Gly Pro Asp Ala Phe Ala Ile Val Glu Arg Ala Gln Gln Met Val 
385                 390                 395                 400 


Glu Ile Leu Thr Glu Glu Asn Arg Val Leu His Gln Glu Leu Gln Gly 
                405                 410                 415     


Cys Tyr Asp Asn Ala Asp Lys Leu His Lys Phe Glu Lys Glu Leu Gln 
            420                 425                 430         


Ser Ile Ser Glu Ala Tyr Glu Ser Leu Val Lys Ser Thr Thr Lys Arg 
        435                 440                 445             


Glu Ser Leu Asp Lys Ala Met Arg Asn Lys Leu Glu Gly Glu Ile Arg 
    450                 455                 460                 


Arg Leu His Asp Phe Asn Arg Asp Leu Arg Asp Arg Leu Glu Thr Ala 
465                 470                 475                 480 


Asn Arg Gln Leu Ser Ser Arg Glu Tyr Glu Gly His Glu Asp Lys Ala 
                485                 490                 495     


Ala Glu Ser His His Met Ser Gln Asn Lys Glu Phe Leu Lys Glu Lys 
            500                 505                 510         


Glu Lys Leu Glu Met Glu Leu Ala Ala Val Arg Thr Ala Ser Glu Asp 
        515                 520                 525             


His Arg Arg His Ile Glu Ile Leu Asp Gln Ala Leu Ser Asn Ala Gln 
    530                 535                 540                 


Ala Arg Val Ile Lys Leu Glu Glu Glu Leu Arg Glu Lys Gln Ala Tyr 
545                 550                 555                 560 


Val Glu Lys Val Glu Lys Leu Gln Gln Ala Leu Thr Gln Leu Gln Ser 
                565                 570                 575     


Ala Cys Glu Lys Arg Gly Gln Met Glu Arg Arg Leu Arg Thr Trp Leu 
            580                 585                 590         


Glu Arg Glu Leu Asp Ala Leu Arg Thr Gln Gln Lys His Gly Asn Gly 
        595                 600                 605             


Gln Pro Val Asn Leu Pro Glu Tyr Asn Ala Pro Ala Leu Met Glu Leu 
    610                 615                 620                 


Val Arg Glu Lys Glu Glu Arg Ile Leu Ala Leu Glu Ala Asp Met Thr 
625                 630                 635                 640 


Lys Trp Glu Gln Lys Tyr Leu Glu Glu Ser Thr Ile Arg His Phe Ala 
                645                 650                 655     


Met Ser Ala Ala Ala Ala Ala Thr Ala Glu Arg Asp Thr Thr Ile Ser 
            660                 665                 670         


Asn His Ser Arg Asn Gly Ser Tyr Gly Glu Ser Ser Leu Glu Ala His 
        675                 680                 685             


Ile Trp Pro Glu Glu Glu Glu Val Val Gln Ala Asn Arg Arg Cys Gln 
    690                 695                 700                 


Asp Met Glu Tyr Thr Ile Lys Asn Leu His Ala Lys Ile Ile Glu Lys 
705                 710                 715                 720 


Asp Ala Met Ile Lys Val Leu Gln Gln Arg Ser Arg Lys Asp Ala Gly 
                725                 730                 735     


Lys Thr Asp Ser Ser Ser Leu Arg Pro Ala Arg Ser Val Pro Ser Ile 
            740                 745                 750         


Ala Ala Ala Thr Gly Thr His Ser Arg Gln Thr Ser Leu Thr Ser Gly 
        755                 760                 765             


Gln Leu Ala Glu Asp Lys Lys Glu Glu Lys Thr Trp Lys Gly Ser Ile 
    770                 775                 780                 


Gly Phe Leu Leu Gly Lys Glu His Gln Gly Gln Ala Ser Ala Pro Leu 
785                 790                 795                 800 


Leu Pro Ala Thr Pro Ala Ser Ala Leu Ser Pro Pro Thr Ser Thr Thr 
                805                 810                 815     


Ser Ala Ser Ser Thr His Ala Lys Thr Gly Ser Lys Asp Ser Ser Thr 
            820                 825                 830         


Gln Thr Asp Lys Ile Thr Glu Leu Phe Trp Pro Ser Met Ala Ser Leu 
        835                 840                 845             


Pro Ser Arg Gly Arg Leu Ser Thr Ala Pro Ser Asn Ser Pro Val Leu 
    850                 855                 860                 


Lys His Pro Ala Ala Lys Gly Thr Val Glu Lys Gln Glu Asn Ser Pro 
865                 870                 875                 880 


Gly His Gly Lys Ser Ser Glu His Arg Gly Arg Val Ser Ser Leu Leu 
                885                 890                 895     


Gln Lys Pro Glu Phe Pro Asp Gly Glu Ile Met Glu Val Leu Ile 
            900                 905                 910     


<210>  19
<211>  15
<212>  DNA
<213>  artificial

<220>
<223>  siRNA against Fat4

<400>  19
ccgacccgag agatt                                                        15


<210>  20
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  siRNA against Fat4

<400>  20
ccgccggaac gtt                                                          13


<210>  21
<211>  13
<212>  DNA
<213>  artificial

<220>
<223>  siRNA against Amotl1

<400>  21
accaccaggg gtt                                                          13


<210>  22
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  siRNA against Amotl1

<400>  22
gagaccagag gccatt                                                       16


<210>  23
<211>  17
<212>  DNA
<213>  artificial

<220>
<223>  siRNA against Amotl1

<400>  23
cacacagccc agaaatt                                                      17


<210>  24
<211>  15
<212>  DNA
<213>  artificial

<220>
<223>  siRNA against  Yap1

<400>  24
gcagagaacc aaatt                                                        15


<210>  25

<400>  25
000

<210>  26
<211>  21
<212>  RNA
<213>  artificial

<220>
<223>  siRNA anti-Fat4

<400>  26
cggugcuaga uaucaaugau u                                                 21


<210>  27
<211>  21
<212>  RNA
<213>  artificial

<220>
<223>  siRNA anti-Yap1

<400>  27
ggucagagau acuucuuaau u                                                 21


