                         SEQUENCE LISTING

<110>  VIB VZW
       VRIJE UNIVERSITEIT BRUSSEL
       THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR 
       UNIVERSITY
 
<120>  Opioid receptor binding agents and uses thereof

<130>  JaSt/MOR/482

<150>  US 61/933,742
<151>  2014-01-30

<160>  81    

<170>  PatentIn version 3.5

<210>  1
<211>  148
<212>  PRT
<213>  Lama glama

<400>  1

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Arg Arg Leu Ser Cys Val Asp Ser Glu Arg Thr Ser Tyr Pro Met 
            20                  25                  30          


Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ser 
        35                  40                  45              


Ile Thr Trp Ser Gly Ile Asp Pro Thr Tyr Ala Asp Ser Val Ala Asp 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Val Ala Asn Asn Thr Leu Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Lys His Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
                85                  90                  95      


Arg Ala Pro Val Gly Gln Ser Ser Ser Pro Tyr Asp Tyr Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala His His His 
        115                 120                 125             


His His His Gly Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
    130                 135                 140                 


Asn Gly Ala Ala 
145             


<210>  2
<211>  148
<212>  PRT
<213>  Lama glama

<400>  2

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Asp Ser Glu Arg Thr Ser Tyr Pro Met 
            20                  25                  30          


Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ser 
        35                  40                  45              


Ile Thr Trp Ser Gly Ile Asp Pro Thr Tyr Ala Asp Ser Val Ala Asp 
    50                  55                  60                  


Arg Phe Thr Thr Ser Arg Asp Val Ala Asn Asn Thr Leu Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Lys His Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
                85                  90                  95      


Arg Ala Pro Val Gly Gln Ser Ser Ser Pro Tyr Asp Tyr Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala His His His 
        115                 120                 125             


His His His Gly Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
    130                 135                 140                 


Asn Gly Ala Ala 
145             


<210>  3
<211>  148
<212>  PRT
<213>  Lama glama

<400>  3

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Asp Ser Gly Arg Thr Ser Tyr Pro Met 
            20                  25                  30          


Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ser 
        35                  40                  45              


Ile Thr Trp Ser Gly Ile Asp Pro Thr Tyr Ala Asp Ser Val Ala Asp 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Val Ala Asn Asn Thr Leu Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Lys His Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
                85                  90                  95      


Arg Ala Pro Val Gly Gln Ser Ser Ser Pro Tyr Asp Tyr Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala His His His 
        115                 120                 125             


His His His Gly Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
    130                 135                 140                 


Asn Gly Ala Ala 
145             


<210>  4
<211>  148
<212>  PRT
<213>  Lama glama

<400>  4

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Asp Ser Glu Arg Thr Ser Tyr Pro Met 
            20                  25                  30          


Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ser 
        35                  40                  45              


Ile Thr Trp Ser Gly Ile Asp Pro Thr Tyr Ala Asp Ser Val Ala Asp 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Val Ala Asn Asn Thr Leu Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Lys His Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
                85                  90                  95      


Arg Ala Pro Val Gly Gln Ser Ser Ser Pro Tyr Asp Tyr Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala His His His 
        115                 120                 125             


His His His Gly Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
    130                 135                 140                 


Asn Gly Ala Ala 
145             


<210>  5
<211>  149
<212>  PRT
<213>  Lama glama

<400>  5

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser Ser Ile Ser 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Asn Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Thr Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Phe Lys Tyr Tyr Ser Gly Ser Tyr Phe Tyr Lys Ser Glu Tyr Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala His His 
        115                 120                 125             


His His His His Gly Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp 
    130                 135                 140                 


Leu Asn Gly Ala Ala 
145                 


<210>  6
<211>  150
<212>  PRT
<213>  Lama glama

<400>  6

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Ile Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Asn Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Ser Arg Ser Cys Gly Arg Gly Tyr Arg Tyr Leu Glu 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala His 
        115                 120                 125             


His His His His His Gly Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu 
    130                 135                 140                 


Asp Leu Asn Gly Ala Ala 
145                 150 


<210>  7
<211>  25
<212>  PRT
<213>  Lama glama

<400>  7

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Arg Arg Leu Ser Cys Val Asp Ser 
            20                  25  


<210>  8
<211>  25
<212>  PRT
<213>  Lama glama

<400>  8

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Asp Ser 
            20                  25  


<210>  9
<211>  25
<212>  PRT
<213>  Lama glama

<400>  9

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Asp Ser 
            20                  25  


<210>  10
<211>  25
<212>  PRT
<213>  Lama glama

<400>  10

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Asp Ser 
            20                  25  


<210>  11
<211>  25
<212>  PRT
<213>  Lama glama

<400>  11

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  12
<211>  25
<212>  PRT
<213>  Lama glama

<400>  12

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  13
<211>  6
<212>  PRT
<213>  Lama glama

<400>  13

Glu Arg Thr Ser Tyr Pro 
1               5       


<210>  14
<211>  6
<212>  PRT
<213>  Lama glama

<400>  14

Glu Arg Thr Ser Tyr Pro 
1               5       


<210>  15
<211>  6
<212>  PRT
<213>  Lama glama

<400>  15

Gly Arg Thr Ser Tyr Pro 
1               5       


<210>  16
<211>  6
<212>  PRT
<213>  Lama glama

<400>  16

Glu Arg Thr Ser Tyr Pro 
1               5       


<210>  17
<211>  8
<212>  PRT
<213>  Lama glama

<400>  17

Gly Ser Ile Ser Ser Ile Ser Thr 
1               5               


<210>  18
<211>  8
<212>  PRT
<213>  Lama glama

<400>  18

Gly Phe Thr Phe Asp Asp Tyr Ala 
1               5               


<210>  19
<211>  17
<212>  PRT
<213>  Lama glama

<400>  19

Met Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val Ala 
1               5                   10                  15      


Ser 
    


<210>  20
<211>  17
<212>  PRT
<213>  Lama glama

<400>  20

Met Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val Ala 
1               5                   10                  15      


Ser 
    


<210>  21
<211>  17
<212>  PRT
<213>  Lama glama

<400>  21

Met Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val Ala 
1               5                   10                  15      


Ser 
    


<210>  22
<211>  17
<212>  PRT
<213>  Lama glama

<400>  22

Met Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val Ala 
1               5                   10                  15      


Ser 
    


<210>  23
<211>  17
<212>  PRT
<213>  Lama glama

<400>  23

Met Gly Trp Tyr Arg Gln Ala Pro Gly Asn Glu Arg Glu Leu Val Ala 
1               5                   10                  15      


Ala 
    


<210>  24
<211>  17
<212>  PRT
<213>  Lama glama

<400>  24

Ile Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ser 
1               5                   10                  15      


Cys 
    


<210>  25
<211>  8
<212>  PRT
<213>  Lama glama

<400>  25

Ile Thr Trp Ser Gly Ile Asp Pro 
1               5               


<210>  26
<211>  8
<212>  PRT
<213>  Lama glama

<400>  26

Ile Thr Trp Ser Gly Ile Asp Pro 
1               5               


<210>  27
<211>  8
<212>  PRT
<213>  Lama glama

<400>  27

Ile Thr Trp Ser Gly Ile Asp Pro 
1               5               


<210>  28
<211>  8
<212>  PRT
<213>  Lama glama

<400>  28

Ile Thr Trp Ser Gly Ile Asp Pro 
1               5               


<210>  29
<211>  7
<212>  PRT
<213>  Lama glama

<400>  29

Ile Thr Ser Gly Gly Ser Thr 
1               5           


<210>  30
<211>  8
<212>  PRT
<213>  Lama glama

<400>  30

Ile Ser Ser Ser Asp Gly Ser Thr 
1               5               


<210>  31
<211>  38
<212>  PRT
<213>  Lama glama

<400>  31

Thr Tyr Ala Asp Ser Val Ala Asp Arg Phe Thr Ile Ser Arg Asp Val 
1               5                   10                  15      


Ala Asn Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys His Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  32
<211>  38
<212>  PRT
<213>  Lama glama

<400>  32

Thr Tyr Ala Asp Ser Val Ala Asp Arg Phe Thr Thr Ser Arg Asp Val 
1               5                   10                  15      


Ala Asn Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys His Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  33
<211>  38
<212>  PRT
<213>  Lama glama

<400>  33

Thr Tyr Ala Asp Ser Val Ala Asp Arg Phe Thr Ile Ser Arg Asp Val 
1               5                   10                  15      


Ala Asn Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys His Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  34
<211>  38
<212>  PRT
<213>  Lama glama

<400>  34

Thr Tyr Ala Asp Ser Val Ala Asp Arg Phe Thr Ile Ser Arg Asp Val 
1               5                   10                  15      


Ala Asn Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys His Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  35
<211>  38
<212>  PRT
<213>  Lama glama

<400>  35

Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  36
<211>  38
<212>  PRT
<213>  Lama glama

<400>  36

Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Asn Asp Asn 
1               5                   10                  15      


Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  37
<211>  17
<212>  PRT
<213>  Lama glama

<400>  37

Ala Ala Arg Ala Pro Val Gly Gln Ser Ser Ser Pro Tyr Asp Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210>  38
<211>  17
<212>  PRT
<213>  Lama glama

<400>  38

Ala Ala Arg Ala Pro Val Gly Gln Ser Ser Ser Pro Tyr Asp Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210>  39
<211>  17
<212>  PRT
<213>  Lama glama

<400>  39

Ala Ala Arg Ala Pro Val Gly Gln Ser Ser Ser Pro Tyr Asp Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210>  40
<211>  17
<212>  PRT
<213>  Lama glama

<400>  40

Ala Ala Arg Ala Pro Val Gly Gln Ser Ser Ser Pro Tyr Asp Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210>  41
<211>  17
<212>  PRT
<213>  Lama glama

<400>  41

Asn Phe Lys Tyr Tyr Ser Gly Ser Tyr Phe Tyr Lys Ser Glu Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210>  42
<211>  17
<212>  PRT
<213>  Lama glama

<400>  42

Ala Ala Asp Leu Ser Arg Ser Cys Gly Arg Gly Tyr Arg Tyr Leu Glu 
1               5                   10                  15      


Val 
    


<210>  43
<211>  37
<212>  PRT
<213>  Lama glama

<400>  43

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala His His 
1               5                   10                  15      


His His His His Gly Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp 
            20                  25                  30          


Leu Asn Gly Ala Ala 
        35          


<210>  44
<211>  37
<212>  PRT
<213>  Lama glama

<400>  44

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala His His 
1               5                   10                  15      


His His His His Gly Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp 
            20                  25                  30          


Leu Asn Gly Ala Ala 
        35          


<210>  45
<211>  37
<212>  PRT
<213>  Lama glama

<400>  45

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala His His 
1               5                   10                  15      


His His His His Gly Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp 
            20                  25                  30          


Leu Asn Gly Ala Ala 
        35          


<210>  46
<211>  37
<212>  PRT
<213>  Lama glama

<400>  46

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala His His 
1               5                   10                  15      


His His His His Gly Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp 
            20                  25                  30          


Leu Asn Gly Ala Ala 
        35          


<210>  47
<211>  37
<212>  PRT
<213>  Lama glama

<400>  47

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala His His 
1               5                   10                  15      


His His His His Gly Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp 
            20                  25                  30          


Leu Asn Gly Ala Ala 
        35          


<210>  48
<211>  37
<212>  PRT
<213>  Lama glama

<400>  48

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala His His 
1               5                   10                  15      


His His His His Gly Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp 
            20                  25                  30          


Leu Asn Gly Ala Ala 
        35          


<210>  49
<211>  278
<212>  PRT
<213>  Lama glama

<400>  49

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser Ser Ile Ser 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Asn Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Thr Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Phe Lys Tyr Tyr Ser Gly Ser Tyr Phe Tyr Lys Ser Glu Tyr Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val 
    130                 135                 140                 


Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile 
145                 150                 155                 160 


Ser Ser Ile Ser Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Asn Glu 
                165                 170                 175     


Arg Glu Leu Val Ala Ala Ile Thr Ser Gly Gly Ser Thr Asn Tyr Ala 
            180                 185                 190         


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
        195                 200                 205             


Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Asn Phe Lys Tyr Tyr Ser Gly Ser Tyr Phe Tyr Lys Ser 
225                 230                 235                 240 


Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala 
                245                 250                 255     


Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala 
            260                 265                 270         


His His His His His His 
        275             


<210>  50
<211>  400
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Asp Ser Ser Ala Ala Pro Thr Asn Ala Ser Asn Cys Thr Asp Ala 
1               5                   10                  15      


Leu Ala Tyr Ser Ser Cys Ser Pro Ala Pro Ser Pro Gly Ser Trp Val 
            20                  25                  30          


Asn Leu Ser His Leu Asp Gly Asn Leu Ser Asp Pro Cys Gly Pro Asn 
        35                  40                  45              


Arg Thr Asp Leu Gly Gly Arg Asp Ser Leu Cys Pro Pro Thr Gly Ser 
    50                  55                  60                  


Pro Ser Met Ile Thr Ala Ile Thr Ile Met Ala Leu Tyr Ser Ile Val 
65                  70                  75                  80  


Cys Val Val Gly Leu Phe Gly Asn Phe Leu Val Met Tyr Val Ile Val 
                85                  90                  95      


Arg Tyr Thr Lys Met Lys Thr Ala Thr Asn Ile Tyr Ile Phe Asn Leu 
            100                 105                 110         


Ala Leu Ala Asp Ala Leu Ala Thr Ser Thr Leu Pro Phe Gln Ser Val 
        115                 120                 125             


Asn Tyr Leu Met Gly Thr Trp Pro Phe Gly Thr Ile Leu Cys Lys Ile 
    130                 135                 140                 


Val Ile Ser Ile Asp Tyr Tyr Asn Met Phe Thr Ser Ile Phe Thr Leu 
145                 150                 155                 160 


Cys Thr Met Ser Val Asp Arg Tyr Ile Ala Val Cys His Pro Val Lys 
                165                 170                 175     


Ala Leu Asp Phe Arg Thr Pro Arg Asn Ala Lys Ile Ile Asn Val Cys 
            180                 185                 190         


Asn Trp Ile Leu Ser Ser Ala Ile Gly Leu Pro Val Met Phe Met Ala 
        195                 200                 205             


Thr Thr Lys Tyr Arg Gln Gly Ser Ile Asp Cys Thr Leu Thr Phe Ser 
    210                 215                 220                 


His Pro Thr Trp Tyr Trp Glu Asn Leu Leu Lys Ile Cys Val Phe Ile 
225                 230                 235                 240 


Phe Ala Phe Ile Met Pro Val Leu Ile Ile Thr Val Cys Tyr Gly Leu 
                245                 250                 255     


Met Ile Leu Arg Leu Lys Ser Val Arg Met Leu Ser Gly Ser Lys Glu 
            260                 265                 270         


Lys Asp Arg Asn Leu Arg Arg Ile Thr Arg Met Val Leu Val Val Val 
        275                 280                 285             


Ala Val Phe Ile Val Cys Trp Thr Pro Ile His Ile Tyr Val Ile Ile 
    290                 295                 300                 


Lys Ala Leu Val Thr Ile Pro Glu Thr Thr Phe Gln Thr Val Ser Trp 
305                 310                 315                 320 


His Phe Cys Ile Ala Leu Gly Tyr Thr Asn Ser Cys Leu Asn Pro Val 
                325                 330                 335     


Leu Tyr Ala Phe Leu Asp Glu Asn Phe Lys Arg Cys Phe Arg Glu Phe 
            340                 345                 350         


Cys Ile Pro Thr Ser Ser Asn Ile Glu Gln Gln Asn Ser Thr Arg Ile 
        355                 360                 365             


Arg Gln Asn Thr Arg Asp His Pro Ser Thr Ala Asn Thr Val Asp Arg 
    370                 375                 380                 


Thr Asn His Gln Leu Glu Asn Leu Glu Ala Glu Thr Ala Pro Leu Pro 
385                 390                 395                 400 


<210>  51
<211>  398
<212>  PRT
<213>  Mus musculus

<400>  51

Met Asp Ser Ser Ala Gly Pro Gly Asn Ile Ser Asp Cys Ser Asp Pro 
1               5                   10                  15      


Leu Ala Pro Ala Ser Cys Ser Pro Ala Pro Gly Ser Trp Leu Asn Leu 
            20                  25                  30          


Ser His Val Asp Gly Asn Gln Ser Asp Pro Cys Gly Pro Asn Arg Thr 
        35                  40                  45              


Gly Leu Gly Gly Ser His Ser Leu Cys Pro Gln Thr Gly Ser Pro Ser 
    50                  55                  60                  


Met Val Thr Ala Ile Thr Ile Met Ala Leu Tyr Ser Ile Val Cys Val 
65                  70                  75                  80  


Val Gly Leu Phe Gly Asn Phe Leu Val Met Tyr Val Ile Val Arg Tyr 
                85                  90                  95      


Thr Lys Met Lys Thr Ala Thr Asn Ile Tyr Ile Phe Asn Leu Ala Leu 
            100                 105                 110         


Ala Asp Ala Leu Ala Thr Ser Thr Leu Pro Phe Gln Ser Val Asn Tyr 
        115                 120                 125             


Leu Met Gly Thr Trp Pro Phe Gly Asn Ile Leu Cys Lys Ile Val Ile 
    130                 135                 140                 


Ser Ile Asp Tyr Tyr Asn Met Phe Thr Ser Ile Phe Thr Leu Cys Thr 
145                 150                 155                 160 


Met Ser Val Asp Arg Tyr Ile Ala Val Cys His Pro Val Lys Ala Leu 
                165                 170                 175     


Asp Phe Arg Thr Pro Arg Asn Ala Lys Ile Val Asn Val Cys Asn Trp 
            180                 185                 190         


Ile Leu Ser Ser Ala Ile Gly Leu Pro Val Met Phe Met Ala Thr Thr 
        195                 200                 205             


Lys Tyr Arg Gln Gly Ser Ile Asp Cys Thr Leu Thr Phe Ser His Pro 
    210                 215                 220                 


Thr Trp Tyr Trp Glu Asn Leu Leu Lys Ile Cys Val Phe Ile Phe Ala 
225                 230                 235                 240 


Phe Ile Met Pro Val Leu Ile Ile Thr Val Cys Tyr Gly Leu Met Ile 
                245                 250                 255     


Leu Arg Leu Lys Ser Val Arg Met Leu Ser Gly Ser Lys Glu Lys Asp 
            260                 265                 270         


Arg Asn Leu Arg Arg Ile Thr Arg Met Val Leu Val Val Val Ala Val 
        275                 280                 285             


Phe Ile Val Cys Trp Thr Pro Ile His Ile Tyr Val Ile Ile Lys Ala 
    290                 295                 300                 


Leu Ile Thr Ile Pro Glu Thr Thr Phe Gln Thr Val Ser Trp His Phe 
305                 310                 315                 320 


Cys Ile Ala Leu Gly Tyr Thr Asn Ser Cys Leu Asn Pro Val Leu Tyr 
                325                 330                 335     


Ala Phe Leu Asp Glu Asn Phe Lys Arg Cys Phe Arg Glu Phe Cys Ile 
            340                 345                 350         


Pro Thr Ser Ser Thr Ile Glu Gln Gln Asn Ser Ala Arg Ile Arg Gln 
        355                 360                 365             


Asn Thr Arg Glu His Pro Ser Thr Ala Asn Thr Val Asp Arg Thr Asn 
    370                 375                 380                 


His Gln Leu Glu Asn Leu Glu Ala Glu Thr Ala Pro Leu Pro 
385                 390                 395             


<210>  52
<211>  424
<212>  PRT
<213>  Mus musculus

<400>  52

Asp Tyr Lys Asp Asp Asp Asp Ala Met Gly Pro Gly Asn Ile Ser Asp 
1               5                   10                  15      


Cys Ser Asp Pro Leu Ala Pro Ala Ser Cys Ser Pro Ala Pro Gly Ser 
            20                  25                  30          


Trp Leu Asn Leu Ser His Val Asp Gly Asn Gln Ser Asp Pro Cys Gly 
        35                  40                  45              


Pro Asn Arg Thr Gly Leu Gly Glu Asn Leu Tyr Phe Gln Gly Ser His 
    50                  55                  60                  


Ser Leu Cys Pro Gln Thr Gly Ser Pro Ser Met Val Thr Ala Ile Thr 
65                  70                  75                  80  


Ile Met Ala Leu Tyr Ser Ile Val Cys Val Val Gly Leu Phe Gly Asn 
                85                  90                  95      


Phe Leu Val Met Tyr Val Ile Val Arg Tyr Thr Lys Met Lys Thr Ala 
            100                 105                 110         


Thr Asn Ile Tyr Ile Phe Asn Leu Ala Leu Ala Asp Ala Leu Ala Thr 
        115                 120                 125             


Ser Thr Leu Pro Phe Gln Ser Val Asn Tyr Leu Met Gly Thr Trp Pro 
    130                 135                 140                 


Phe Gly Asn Ile Leu Cys Lys Ile Val Ile Ser Ile Asp Tyr Tyr Asn 
145                 150                 155                 160 


Met Phe Thr Ser Ile Phe Thr Leu Cys Thr Met Ser Val Asp Arg Tyr 
                165                 170                 175     


Ile Ala Val Cys His Pro Val Lys Ala Leu Asp Phe Arg Thr Pro Arg 
            180                 185                 190         


Asn Ala Lys Ile Val Asn Val Cys Asn Trp Ile Leu Ser Ser Ala Ile 
        195                 200                 205             


Gly Leu Pro Val Met Phe Met Ala Thr Thr Lys Tyr Arg Gln Gly Ser 
    210                 215                 220                 


Ile Asp Cys Thr Leu Thr Phe Ser His Pro Thr Trp Tyr Trp Glu Asn 
225                 230                 235                 240 


Leu Leu Lys Ile Cys Val Phe Ile Phe Ala Phe Ile Met Pro Val Leu 
                245                 250                 255     


Ile Ile Thr Val Cys Tyr Gly Leu Met Ile Leu Arg Leu Lys Ser Val 
            260                 265                 270         


Arg Met Leu Ser Gly Ser Lys Glu Lys Asp Arg Asn Leu Arg Arg Ile 
        275                 280                 285             


Thr Arg Met Val Leu Val Val Val Ala Val Phe Ile Val Cys Trp Thr 
    290                 295                 300                 


Pro Ile His Ile Tyr Val Ile Ile Lys Ala Leu Ile Thr Ile Pro Glu 
305                 310                 315                 320 


Thr Thr Phe Gln Thr Val Ser Trp His Phe Cys Ile Ala Leu Gly Tyr 
                325                 330                 335     


Thr Asn Ser Cys Leu Asn Pro Val Leu Tyr Ala Phe Leu Asp Glu Asn 
            340                 345                 350         


Phe Lys Arg Cys Phe Arg Glu Phe Cys Ile Pro Thr Ser Ser Thr Ile 
        355                 360                 365             


Leu Glu Val Leu Phe Gln Gly Pro Glu Gln Gln Asn Ser Ala Arg Ile 
    370                 375                 380                 


Arg Gln Asn Thr Arg Glu His Pro Ser Thr Ala Asn Thr Val Asp Arg 
385                 390                 395                 400 


Thr Asn His Gln Leu Glu Asn Leu Glu Ala Glu Thr Ala Pro Leu Pro 
                405                 410                 415     


Asp Ile His His His His His His 
            420                 


<210>  53
<211>  380
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Asp Ser Pro Ile Gln Ile Phe Arg Gly Glu Pro Gly Pro Thr Cys 
1               5                   10                  15      


Ala Pro Ser Ala Cys Leu Pro Pro Asn Ser Ser Ala Trp Phe Pro Gly 
            20                  25                  30          


Trp Ala Glu Pro Asp Ser Asn Gly Ser Ala Gly Ser Glu Asp Ala Gln 
        35                  40                  45              


Leu Glu Pro Ala His Ile Ser Pro Ala Ile Pro Val Ile Ile Thr Ala 
    50                  55                  60                  


Val Tyr Ser Val Val Phe Val Val Gly Leu Val Gly Asn Ser Leu Val 
65                  70                  75                  80  


Met Phe Val Ile Ile Arg Tyr Thr Lys Met Lys Thr Ala Thr Asn Ile 
                85                  90                  95      


Tyr Ile Phe Asn Leu Ala Leu Ala Asp Ala Leu Val Thr Thr Thr Met 
            100                 105                 110         


Pro Phe Gln Ser Thr Val Tyr Leu Met Asn Ser Trp Pro Phe Gly Asp 
        115                 120                 125             


Val Leu Cys Lys Ile Val Ile Ser Ile Asp Tyr Tyr Asn Met Phe Thr 
    130                 135                 140                 


Ser Ile Phe Thr Leu Thr Met Met Ser Val Asp Arg Tyr Ile Ala Val 
145                 150                 155                 160 


Cys His Pro Val Lys Ala Leu Asp Phe Arg Thr Pro Leu Lys Ala Lys 
                165                 170                 175     


Ile Ile Asn Ile Cys Ile Trp Leu Leu Ser Ser Ser Val Gly Ile Ser 
            180                 185                 190         


Ala Ile Val Leu Gly Gly Thr Lys Val Arg Glu Asp Val Asp Val Ile 
        195                 200                 205             


Glu Cys Ser Leu Gln Phe Pro Asp Asp Asp Tyr Ser Trp Trp Asp Leu 
    210                 215                 220                 


Phe Met Lys Ile Cys Val Phe Ile Phe Ala Phe Val Ile Pro Val Leu 
225                 230                 235                 240 


Ile Ile Ile Val Cys Tyr Thr Leu Met Ile Leu Arg Leu Lys Ser Val 
                245                 250                 255     


Arg Leu Leu Ser Gly Ser Arg Glu Lys Asp Arg Asn Leu Arg Arg Ile 
            260                 265                 270         


Thr Arg Leu Val Leu Val Val Val Ala Val Phe Val Val Cys Trp Thr 
        275                 280                 285             


Pro Ile His Ile Phe Ile Leu Val Glu Ala Leu Gly Ser Thr Ser His 
    290                 295                 300                 


Ser Thr Ala Ala Leu Ser Ser Tyr Tyr Phe Cys Ile Ala Leu Gly Tyr 
305                 310                 315                 320 


Thr Asn Ser Ser Leu Asn Pro Ile Leu Tyr Ala Phe Leu Asp Glu Asn 
                325                 330                 335     


Phe Lys Arg Cys Phe Arg Asp Phe Cys Phe Pro Leu Lys Met Arg Met 
            340                 345                 350         


Glu Arg Gln Ser Thr Ser Arg Val Arg Asn Thr Val Gln Asp Pro Ala 
        355                 360                 365             


Tyr Leu Arg Asp Ile Asp Gly Met Asn Lys Pro Val 
    370                 375                 380 


<210>  54
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Glu Pro Ala Pro Ser Ala Gly Ala Glu Leu Gln Pro Pro Leu Phe 
1               5                   10                  15      


Ala Asn Ala Ser Asp Ala Tyr Pro Ser Ala Cys Pro Ser Ala Gly Ala 
            20                  25                  30          


Asn Ala Ser Gly Pro Pro Gly Ala Arg Ser Ala Ser Ser Leu Ala Leu 
        35                  40                  45              


Ala Ile Ala Ile Thr Ala Leu Tyr Ser Ala Val Cys Ala Val Gly Leu 
    50                  55                  60                  


Leu Gly Asn Val Leu Val Met Phe Gly Ile Val Arg Tyr Thr Lys Met 
65                  70                  75                  80  


Lys Thr Ala Thr Asn Ile Tyr Ile Phe Asn Leu Ala Leu Ala Asp Ala 
                85                  90                  95      


Leu Ala Thr Ser Thr Leu Pro Phe Gln Ser Ala Lys Tyr Leu Met Glu 
            100                 105                 110         


Thr Trp Pro Phe Gly Glu Leu Leu Cys Lys Ala Val Leu Ser Ile Asp 
        115                 120                 125             


Tyr Tyr Asn Met Phe Thr Ser Ile Phe Thr Leu Thr Met Met Ser Val 
    130                 135                 140                 


Asp Arg Tyr Ile Ala Val Cys His Pro Val Lys Ala Leu Asp Phe Arg 
145                 150                 155                 160 


Thr Pro Ala Lys Ala Lys Leu Ile Asn Ile Cys Ile Trp Val Leu Ala 
                165                 170                 175     


Ser Gly Val Gly Val Pro Ile Met Val Met Ala Val Thr Arg Pro Arg 
            180                 185                 190         


Asp Gly Ala Val Val Cys Met Leu Gln Phe Pro Ser Pro Ser Trp Tyr 
        195                 200                 205             


Trp Asp Thr Val Thr Lys Ile Cys Val Phe Leu Phe Ala Phe Val Val 
    210                 215                 220                 


Pro Ile Leu Ile Ile Thr Val Cys Tyr Gly Leu Met Leu Leu Arg Leu 
225                 230                 235                 240 


Arg Ser Val Arg Leu Leu Ser Gly Ser Lys Glu Lys Asp Arg Ser Leu 
                245                 250                 255     


Arg Arg Ile Thr Arg Met Val Leu Val Val Val Gly Ala Phe Val Val 
            260                 265                 270         


Cys Trp Ala Pro Ile His Ile Phe Val Ile Val Trp Thr Leu Val Asp 
        275                 280                 285             


Ile Asp Arg Arg Asp Pro Leu Val Val Ala Ala Leu His Leu Cys Ile 
    290                 295                 300                 


Ala Leu Gly Tyr Ala Asn Ser Ser Leu Asn Pro Val Leu Tyr Ala Phe 
305                 310                 315                 320 


Leu Asp Glu Asn Phe Lys Arg Cys Phe Arg Gln Leu Cys Arg Lys Pro 
                325                 330                 335     


Cys Gly Arg Pro Asp Pro Ser Ser Phe Ser Arg Ala Arg Glu Ala Thr 
            340                 345                 350         


Ala Arg Glu Arg Val Thr Ala Cys Thr Pro Ser Asp Gly Pro Gly Gly 
        355                 360                 365             


Gly Ala Ala Ala 
    370         


<210>  55
<211>  370
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Glu Pro Leu Phe Pro Ala Pro Phe Trp Glu Val Ile Tyr Gly Ser 
1               5                   10                  15      


His Leu Gln Gly Asn Leu Ser Leu Leu Ser Pro Asn His Ser Leu Leu 
            20                  25                  30          


Pro Pro His Leu Leu Leu Asn Ala Ser His Gly Ala Phe Leu Pro Leu 
        35                  40                  45              


Gly Leu Lys Val Thr Ile Val Gly Leu Tyr Leu Ala Val Cys Val Gly 
    50                  55                  60                  


Gly Leu Leu Gly Asn Cys Leu Val Met Tyr Val Ile Leu Arg His Thr 
65                  70                  75                  80  


Lys Met Lys Thr Ala Thr Asn Ile Tyr Ile Phe Asn Leu Ala Leu Ala 
                85                  90                  95      


Asp Thr Leu Val Leu Leu Thr Leu Pro Phe Gln Gly Thr Asp Ile Leu 
            100                 105                 110         


Leu Gly Phe Trp Pro Phe Gly Asn Ala Leu Cys Lys Thr Val Ile Ala 
        115                 120                 125             


Ile Asp Tyr Tyr Asn Met Phe Thr Ser Thr Phe Thr Leu Thr Ala Met 
    130                 135                 140                 


Ser Val Asp Arg Tyr Val Ala Ile Cys His Pro Ile Arg Ala Leu Asp 
145                 150                 155                 160 


Val Arg Thr Ser Ser Lys Ala Gln Ala Val Asn Val Ala Ile Trp Ala 
                165                 170                 175     


Leu Ala Ser Val Val Gly Val Pro Val Ala Ile Met Gly Ser Ala Gln 
            180                 185                 190         


Val Glu Asp Glu Glu Ile Glu Cys Leu Val Glu Ile Pro Thr Pro Gln 
        195                 200                 205             


Asp Tyr Trp Gly Pro Val Phe Ala Ile Cys Ile Phe Leu Phe Ser Phe 
    210                 215                 220                 


Ile Val Pro Val Leu Val Ile Ser Val Cys Tyr Ser Leu Met Ile Arg 
225                 230                 235                 240 


Arg Leu Arg Gly Val Arg Leu Leu Ser Gly Ser Arg Glu Lys Asp Arg 
                245                 250                 255     


Asn Leu Arg Arg Ile Thr Arg Leu Val Leu Val Val Val Ala Val Phe 
            260                 265                 270         


Val Gly Cys Trp Thr Pro Val Gln Val Phe Val Leu Ala Gln Gly Leu 
        275                 280                 285             


Gly Val Gln Pro Ser Ser Glu Thr Ala Val Ala Ile Leu Arg Phe Cys 
    290                 295                 300                 


Thr Ala Leu Gly Tyr Val Asn Ser Cys Leu Asn Pro Ile Leu Tyr Ala 
305                 310                 315                 320 


Phe Leu Asp Glu Asn Phe Lys Ala Cys Phe Arg Lys Phe Cys Cys Ala 
                325                 330                 335     


Ser Ala Leu Arg Arg Asp Val Gln Val Ser Asp Arg Val Arg Ser Ile 
            340                 345                 350         


Ala Lys Asp Val Ala Leu Ala Cys Lys Thr Ser Glu Thr Val Pro Arg 
        355                 360                 365             


Pro Ala 
    370 


<210>  56
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  56

Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10  


<210>  57
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  57

Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10                  15      


Gly Ser Gly Ser 
            20  


<210>  58
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  58

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  59
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  59

Ala His His Ser Glu Asp Pro Ser Ser Lys Ala Pro Lys Ala Pro Met 
1               5                   10                  15      


Ala 
    


<210>  60
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  60

Ser Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Ala Ser 
1               5                   10                  15      


<210>  61
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Factor Xa cleavage site

<400>  61

Ile Glu Gly Arg 
1               


<210>  62
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  thrombin cleavage site

<400>  62

Leu Val Pro Arg 
1               


<210>  63
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  enterokinase cleaving site

<400>  63

Asp Asp Asp Asp Lys 
1               5   


<210>  64
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PreScission -or 3C- cleavage site

<400>  64

Leu Glu Val Leu Phe Gln Gly Pro 
1               5               


<210>  65
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  65
caggtgcaat tggtggagtc tgggggagg                                         29


<210>  66
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  66
agtaggatcc gccacctcct gaggagaccg tgacctgggt                             40


<210>  67
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  67
tcttggatcc ggcggaggta gtcaggtgca gctgcaggag tctgggggag g                51


<210>  68
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  68
tgaggagacg gtgacctggg t                                                 21


<210>  69
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flag tag encoding AA sequence

<400>  69

Asp Tyr Lys Asp Asp Asp Asp Ala 
1               5               


<210>  70
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AA residues 2-5

<400>  70

Asp Ser Ser Ala 
1               


<210>  71
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TEV cleavage site

<400>  71

Glu Asn Leu Tyr Phe Gln 
1               5       


<210>  72
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3C site

<400>  72

Leu Glu Val Leu Phe Gln Gly Pro 
1               5               


<210>  73
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  histidine tag coding sequence

<400>  73

Asp Ile His His His His His His 
1               5               


<210>  74
<211>  149
<212>  PRT
<213>  Lama glama

<400>  74

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser Ile Phe Ser Ile Ser 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Thr Ile Thr Ser Gly Gly Thr Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Gly Asp Thr Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp Met Glu Val Trp Asp Tyr Thr Asp Gly Asp Asp Asp Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala His His 
        115                 120                 125             


His His His His Gly Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp 
    130                 135                 140                 


Leu Asn Gly Ala Ala 
145                 


<210>  75
<211>  25
<212>  PRT
<213>  Lama glama

<400>  75

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser 
            20                  25  


<210>  76
<211>  8
<212>  PRT
<213>  Lama glama

<400>  76

Gly Ser Ile Phe Ser Ile Ser Ala 
1               5               


<210>  77
<211>  17
<212>  PRT
<213>  Lama glama

<400>  77

Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala 
1               5                   10                  15      


Thr 
    


<210>  78
<211>  7
<212>  PRT
<213>  Lama glama

<400>  78

Ile Thr Ser Gly Gly Thr Thr 
1               5           


<210>  79
<211>  38
<212>  PRT
<213>  Lama glama

<400>  79

Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Gly Asp Thr 
1               5                   10                  15      


Ala Lys Asn Met Val Tyr Leu Gln Met Ser Ser Leu Lys Pro Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  80
<211>  17
<212>  PRT
<213>  Lama glama

<400>  80

Ala Ala Asp Met Glu Val Trp Asp Tyr Thr Asp Gly Asp Asp Asp Asp 
1               5                   10                  15      


Tyr 
    


<210>  81
<211>  37
<212>  PRT
<213>  Lama glama

<400>  81

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala His His 
1               5                   10                  15      


His His His His Gly Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp 
            20                  25                  30          


Leu Asn Gly Ala Ala 
        35          


