                         SEQUENCE LISTING

<110>  The Trustees of the University of Pennsylvania
       Brown University
       Christianson, David W
       Li, Ruiqiong
       Litwin, Kevin
       Crane, David
       Chou, Wayne
       Harris, Golda
       Himmelberger, Julie Anne
 
<120>  Novel Terpene Cyclase Variants, and Methods Using Same

<130>  046483-7008WO1(00941)

<150>  US 61/937,897
<151>  2014-02-10

<160>  49    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chemically synthesized


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  any amino acid

<400>  1

Asp Asp Xaa Xaa Asp 
1               5   


<210>  2
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chemically synthesized


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  any amino residue

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  any amino residue

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  any amino residue

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  any amino residue

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  any amino residue

<400>  2

Asn Asp Xaa Xaa Ser Xaa Xaa Xaa Glu 
1               5                   


<210>  3
<211>  382
<212>  PRT
<213>  Streptomyces coelicolor

<400>  3

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Val His Ala Phe Pro His Gly Thr Thr Ala Thr 
            20                  25                  30          


Pro Thr Ala Ile Ala Val Pro Pro Ser Leu Arg Leu Pro Val Ile Glu 
        35                  40                  45              


Ala Ala Phe Pro Arg Gln Leu His Pro Tyr Trp Pro Lys Leu Gln Glu 
    50                  55                  60                  


Thr Thr Arg Thr Trp Leu Leu Glu Lys Arg Leu Met Pro Ala Asp Lys 
65                  70                  75                  80  


Val Glu Glu Tyr Ala Asp Gly Leu Cys Tyr Thr Asp Leu Met Ala Gly 
                85                  90                  95      


Tyr Tyr Leu Gly Ala Pro Asp Glu Val Leu Gln Ala Ile Ala Asp Tyr 
            100                 105                 110         


Ser Ala Trp Phe Phe Val Trp Asp Asp Arg His Asp Arg Asp Ile Val 
        115                 120                 125             


His Gly Arg Ala Gly Ala Trp Arg Arg Leu Arg Gly Leu Leu His Thr 
    130                 135                 140                 


Ala Leu Asp Ser Pro Gly Asp His Leu His His Glu Asp Thr Leu Val 
145                 150                 155                 160 


Ala Gly Phe Ala Asp Ser Val Arg Arg Leu Tyr Ala Phe Leu Pro Ala 
                165                 170                 175     


Thr Trp Asn Ala Arg Phe Ala Arg His Phe His Thr Val Ile Glu Ala 
            180                 185                 190         


Tyr Asp Arg Glu Phe His Asn Arg Thr Arg Gly Ile Val Pro Gly Val 
        195                 200                 205             


Glu Glu Tyr Leu Glu Leu Arg Arg Leu Thr Phe Ala His Trp Ile Trp 
    210                 215                 220                 


Thr Asp Leu Leu Glu Pro Ser Ser Gly Cys Glu Leu Pro Asp Ala Val 
225                 230                 235                 240 


Arg Lys His Pro Ala Tyr Arg Arg Ala Ala Leu Leu Ser Gln Glu Phe 
                245                 250                 255     


Ala Ala Trp Tyr Asn Asp Leu Cys Ser Leu Pro Lys Glu Ile Ala Gly 
            260                 265                 270         


Asp Glu Val His Asn Leu Gly Ile Ser Leu Ile Thr His His Ser Leu 
        275                 280                 285             


Thr Leu Glu Glu Ala Ile Gly Glu Val Arg Arg Arg Val Glu Glu Cys 
    290                 295                 300                 


Ile Thr Glu Phe Leu Ala Val Glu Arg Asp Ala Leu Arg Phe Ala Asp 
305                 310                 315                 320 


Glu Leu Ala Asp Gly Thr Val Arg Gly Lys Glu Leu Ser Gly Ala Val 
                325                 330                 335     


Arg Ala Asn Val Gly Asn Met Arg Asn Trp Phe Ser Ser Val Tyr Trp 
            340                 345                 350         


Phe His His Glu Ser Gly Arg Tyr Met Val Asp Ser Trp Asp Asp Arg 
        355                 360                 365             


Ser Thr Pro Pro Tyr Val Asn Asn Glu Ala Ala Gly Glu Lys 
    370                 375                 380         


<210>  4
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  4
gtctgtgcta cacggacgct atggcgggct actacctg                               38


<210>  5
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  5
caggtagtag cccgccatag cgtccgtgta gcacagac                               38


<210>  6
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  6
ctgtgctaca cggacgtgat ggcgggctac tac                                    33


<210>  7
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  7
gtagtagccc gccatcacgt ccgtgtagca cag                                    33


<210>  8
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  8
gtctgtgcta cacggacatg atggcgggct actacctg                               38


<210>  9
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  9
caggtagtag cccgccatca tgtccgtgta gcacagac                               38


<210>  10
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  10
gactacagcg cgtgggcatt cgtctgggac gac                                    33


<210>  11
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  11
gtcgtcccag acgaatgccc acgcgctgta gtc                                    33


<210>  12
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  12
gatagcggac tacagcgcgt gggtttttgt ctgggacgac cgtcac                      46


<210>  13
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  13
gtgacggtcg tcccagacaa aaacccacgc gctgtagtcc gctatc                      46


<210>  14
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  14
gatagcggac tacagcgcgt ggatgtttgt ctgggacgac cgtcac                      46


<210>  15
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  15
gtgacggtcg tcccagacaa acatccacgc gctgtagtcc gctatc                      46


<210>  16
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  16
gatagcggac tacagcgcgt ggcattttgt ctgggacgac cgtcac                      46


<210>  17
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  17
gtgacggtcg tcccagacaa aatgccacgc gctgtagtcc gctatc                      46


<210>  18
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  18
gatagcggac tacagcgcgt ggttcgttgt ctgggacgac cgtcac                      46


<210>  19
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  19
gtgacggtcg tcccagacaa cgaaccacgc gctgtagtcc gctatc                      46


<210>  20
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  20
gactacagcg cgtggttctt agtctgggac gaccgtcac                              39


<210>  21
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  21
gtgacggtcg tcccagacta agaaccacgc gctgtagtc                              39


<210>  22
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  22
gatagcggac tacagcgcgt ggttctatgt ctgggacgac cgtcac                      46


<210>  23
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  23
gtgacggtcg tcccagacat agaaccacgc gctgtagtcc gctatc                      46


<210>  24
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  24
gactacagcg cgtggttctg ggtctgggac gaccgtcac                              39


<210>  25
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  25
gtgacggtcg tcccagaccc agaaccacgc gctgtagtc                              39


<210>  26
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  26
gaactgcgcc ggctcacggt tgctcactgg atctggac                               38


<210>  27
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  27
gtccagatcc agtgagcaac cgtgagccgg cgcagttc                               38


<210>  28
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  28
ctcgaactgc gccggctcac gttagcgcac tggatctgga ccgac                       45


<210>  29
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  29
gtcggtccag atccagtgcg ctaacgtgag ccggcgcagt tcgag                       45


<210>  30
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  30
gtacctcgaa ctgcgccggc tcacgtatgc acactggatc tggaccgac                   49


<210>  31
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  31
gtcggtccag atccagtgtg catacgtgag ccggcgcagt tcgaggtac                   49


<210>  32
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  32
gtcaggaatt cggcgcctgg tacaac                                            26


<210>  33
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  33
gttgtaccag gcgccgaatt cctgac                                            26


<210>  34
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  34
gcgttgctga gtcaggaatt ctttgcctgg tacaacgacc tctgc                       45


<210>  35
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  35
gcagaggtcg ttgtaccagg caaagaattc ctgactcagc aacgc                       45


<210>  36
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  36
gcgttgctga gtcaggaatt catggcctgg tacaacgacc tctgc                       45


<210>  37
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  37
gcagaggtcg ttgtaccagg ccatgaattc ctgactcagc aacgc                       45


<210>  38
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  38
ggcaatatgc ggaacttctt cagttccgtc tactg                                  35


<210>  39
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  39
cagtagacgg aactgaagaa gttccgcata ttgcc                                  35


<210>  40
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  40
ctggttcagt tccgcgtact ggttccacc                                         29


<210>  41
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  41
ggtggaacca gtacgcggaa ctgaaccag                                         29


<210>  42
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  42
ctggttcagt tccggttact ggttccacca cgagtc                                 36


<210>  43
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  43
gactcgtggt ggaaccagta accggaactg aaccag                                 36


<210>  44
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  44
ctggttcagt tccatttact ggttccacca cgagtc                                 36


<210>  45
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  45
gactcgtggt ggaaccagta aatggaactg aaccag                                 36


<210>  46
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  46
ctggttcagt tccatgtact ggttccacca cgagtc                                 36


<210>  47
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  47
gactcgtggt ggaaccagta catggaactg aaccag                                 36


<210>  48
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  48
cagttccgtc tactgggcac accacgagtc cggc                                   34


<210>  49
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  49
gccggactcg tggtgtgccc agtagacgga actg                                   34


