                         SEQUENCE LISTING

<110>  Changchun Huapu Biotechnology Co., Ltd.
 
<120>  Inhibitory Oligonucleotides for Treating Tumors

<130>  1402778-00002

<150>  US 61/937,376
<151>  2014-02-07

<160>  52    

<170>  PatentIn version 3.5

<210>  1
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (CCT)8C inhibitory olionucleotide

<400>  1
cctcctcctc ctcctcctcc tcctc                                             25


<210>  2
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (CCT)8CC inhibitory oligonucleotide

<400>  2
cctcctcctc ctcctcctcc tcctcc                                            26


<210>  3
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (CCT)9 inhibitory oligonucleotide

<400>  3
cctcctcctc ctcctcctcc tcctcct                                           27


<210>  4
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Inhibitory oligonucleotide

<400>  4
cctcctcctc ctcctcctcc tcctcctc                                          28


<210>  5
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Inhibitory oligonucleotide

<400>  5
cctcctcctc ctcctcctcc tcctcctcc                                         29


<210>  6
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (CCT)10 inhibitory oligonucleotide

<400>  6
cctcctcctc ctcctcctcc tcctcctcct                                        30


<210>  7
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (CCT)10C inhibitory oligonucleotide

<400>  7
cctcctcctc ctcctcctcc tcctcctcct c                                      31


<210>  8
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (CCT)10CC inhibitory oligonucleotide

<400>  8
cctcctcctc ctcctcctcc tcctcctcct cc                                     32


<210>  9
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (CCT)11 inhibitory oligonucleotide

<400>  9
cctcctcctc ctcctcctcc tcctcctcct cct                                    33


<210>  10
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (CCT)11C inhibitory oligonucleotide

<400>  10
cctcctcctc ctcctcctcc tcctcctcct cctc                                   34


<210>  11
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (CCT)11CC inhibitory oligonucleotide

<400>  11
cctcctcctc ctcctcctcc tcctcctcct cctcc                                  35


<210>  12
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (CCT)12 inhibitory oligonucleotide

<400>  12
cctcctcctc ctcctcctcc tcctcctcct cctcct                                 36


<210>  13
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (CCT)14 inhibitory oligonucleotide

<400>  13
cctcctcctc ctcctcctcc tcctcctcct cctcctcctc ct                          42


<210>  14
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (CCT)16 inhibitory oligonucleotide

<400>  14
cctcctcctc ctcctcctcc tcctcctcct cctcctcctc ctcctcct                    48


<210>  15
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (CCT)6 inhibitory oligonucleotide

<400>  15
cctcctcctc ctcctcct                                                     18


<210>  16
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (CCT)7 inhibitory oligonucleotide

<400>  16
cctcctcctc ctcctcctcc t                                                 21


<210>  17
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CpG2395 TLR9 stimulatory oligonucleotide

<400>  17
tcgtcgtttt cggcgcgcgc cg                                                22


<210>  18
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CpG1826 TLR9 stimulatory oligonucleotide

<400>  18
tccatgacgt tcctgacgtt                                                   20


<210>  19
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CpG2216 stimulatory oligonucleotide

<400>  19
gggggacgat cgtcgggggg                                                   20


<210>  20
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (CCT)8 inhibitory oligonucleotide

<400>  20
cctcctcctc ctcctcctcc tcct                                              24


<210>  21
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Inhibitory oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (4)..(36)
<223>  phosphorothioate-modified

<400>  21
cctcctcctc ctcctcctcc tcctcctcct cctcct                                 36


<210>  22
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Inhibitory oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  phosphorothioate modified

<220>
<221>  modified_base
<222>  (4)..(5)
<223>  phosphorothioate modified

<220>
<221>  modified_base
<222>  (7)..(36)
<223>  phosphorothioate modified

<400>  22
cctcctcctc ctcctcctcc tcctcctcct cctcct                                 36


<210>  23
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Inhibitory oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (4)..(5)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (7)..(8)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (10)..(36)
<223>  phosphorothioate-modified

<400>  23
cctcctcctc ctcctcctcc tcctcctcct cctcct                                 36


<210>  24
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Inhibitory oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (4)..(5)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (7)..(8)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (10)..(11)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (13)..(36)
<223>  phosphorothioate-modified

<400>  24
cctcctcctc ctcctcctcc tcctcctcct cctcct                                 36


<210>  25
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Inhibitory oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (4)..(5)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (7)..(8)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (10)..(11)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (13)..(18)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (20)..(36)
<223>  phosphorothioate-modified

<400>  25
cctcctcctc ctcccctctc tcctcctcct cctcct                                 36


<210>  26
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Inhibitory oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (4)..(5)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (7)..(8)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (10)..(11)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (13)..(14)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (16)..(17)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (19)..(36)
<223>  phosphorothioate-modified

<400>  26
cctcctcctc ctcctcctcc tcctcctcct cctcct                                 36


<210>  27
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Inhibitory oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (4)..(5)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (7)..(8)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (10)..(11)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (13)..(14)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (16)..(17)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (19)..(20)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (22)..(36)
<223>  phosphorothioate-modified

<400>  27
cctcctcctc ctcctcctcc tcctcctcct cctcct                                 36


<210>  28
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Inhibitory oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (4)..(5)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (7)..(8)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (10)..(11)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (13)..(14)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (16)..(17)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (19)..(20)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (22)..(23)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (25)..(36)
<223>  phosphorothioate-modified

<400>  28
cctcctcctc ctcctcctcc tcctcctcct cctcct                                 36


<210>  29
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Inhibitory oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (4)..(5)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (7)..(8)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (10)..(11)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (13)..(14)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (16)..(17)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (19)..(20)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (22)..(23)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (25)..(36)
<223>  phosphorothioate-modified

<400>  29
cctcctcctc ctcctcctcc tcctcctcct cctcct                                 36


<210>  30
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Inhibitory oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (4)..(5)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (7)..(8)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (10)..(11)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (13)..(14)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (16)..(17)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (19)..(20)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (22)..(23)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (25)..(26)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (28)..(36)
<223>  phosphorothioate-modified

<400>  30
cctcctcctc ctcctcctcc tcctcctcct cctcct                                 36


<210>  31
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Inhibitory oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (4)..(5)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (7)..(8)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (10)..(11)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (13)..(14)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (16)..(17)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (19)..(20)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (22)..(23)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (25)..(26)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (28)..(29)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (31)..(37)
<223>  phosphorothioate-modified

<400>  31
cctcctcctc ctcctcctcc tcctcctcct tcctcct                                37


<210>  32
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Inhibitory oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (4)..(5)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (7)..(8)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (10)..(11)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (13)..(14)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (16)..(17)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (19)..(20)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (22)..(23)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (25)..(26)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (28)..(29)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (31)..(32)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (34)..(36)
<223>  phosphorothioate-modified

<400>  32
cctcctcctc ctcctcctcc tcctcctcct cctcct                                 36


<210>  33
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Inhibitory oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (4)..(5)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (7)..(8)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (10)..(11)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (13)..(14)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (16)..(17)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (19)..(20)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (22)..(23)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (25)..(26)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (28)..(29)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (31)..(32)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (34)..(35)
<223>  phosphorothioate-modified

<400>  33
cctcctcctc ctcctcctcc tcctcctcct cctcct                                 36


<210>  34
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Inhibitory oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (4)..(17)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (19)..(36)
<223>  phosphorothioate-modified

<400>  34
cctcctcctc ctcctcctcc tcctcctcct cctcct                                 36


<210>  35
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Inhibitory oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(5)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (6)..(23)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (25)..(36)
<223>  phosphorothioate-modified

<400>  35
cctcctcctc ctcctcctcc tcctcctcct cctcct                                 36


<210>  36
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Inhibitory oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(8)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (10)..(26)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (28)..(36)
<223>  phosphorothioate-modified

<400>  36
cctcctcctc ctcctcctcc tcctcctcct cctcct                                 36


<210>  37
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Inhibitory oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(14)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (16)..(32)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (34)..(36)
<223>  phosphorothioate-modified

<400>  37
cctcctcctc ctcctcctcc tcctcctcct cctcct                                 36


<210>  38
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Inhibitory oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (4)..(14)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (16)..(26)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (28)..(36)
<223>  phosphorothioate-modified

<400>  38
cctcctcctc ctcctcctcc tcctcctcct cctcct                                 36


<210>  39
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Inhibitory oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(5)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (7)..(17)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (19)..(29)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (31)..(36)
<223>  phosphorothioate-modified

<400>  39
cctcctcctc ctcctcctcc tcctcctcct cctcct                                 36


<210>  40
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Inhibitory oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(8)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (10)..(20)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (22)..(32)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (34)..(36)
<223>  phosphorothioate-modified

<400>  40
cctcctcctc ctcctcctcc tcctcctcct cctcct                                 36


<210>  41
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Inhibitory oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(11)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (13)..(23)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (25)..(35)
<223>  phosphorothioate-modified

<400>  41
cctcctcctc ctcctcctcc tcctcctcct cctcct                                 36


<210>  42
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Inhibitory olligonucleotide


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (4)..(11)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (13)..(20)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (22)..(29)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (31)..(36)
<223>  phosphorothioate-modified

<400>  42
cctcctcctc ctcctcctcc tcctcctcct cctcct                                 36


<210>  43
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Inhibitory oligonculeotide


<220>
<221>  modified_base
<222>  (1)..(5)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (7)..(14)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (16)..(23)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (25)..(32)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (34)..(36)
<223>  phosphorothioate-modified

<400>  43
cctcctcctc ctcctcctcc tcctcctcct cctcct                                 36


<210>  44
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Inhibitory oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(8)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (10)..(17)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (19)..(26)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (28)..(35)
<223>  phosphorothioate-modified

<400>  44
cctcctcctc ctcctcctcc tcctcctcct cctcct                                 36


<210>  45
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Inhibitory oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (4)..(8)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (10)..(14)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (16)..(20)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (22)..(26)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (28)..(36)
<223>  phosphorothioate-modified

<400>  45
cctcctcctc ctcctcctcc tcctcctcct cctcct                                 36


<210>  46
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Inhibitory oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(8)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (10)..(14)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (16)..(20)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (22)..(26)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (28)..(29)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (31)..(36)
<223>  phosphorothioate-modified

<400>  46
cctcctcctc ctcctcctcc tcctcctcct cctcct                                 36


<210>  47
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Inhibitory oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(14)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (16)..(20)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (22)..(26)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (28)..(29)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (31)..(32)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (34)..(36)
<223>  phosphorothioate-modified

<400>  47
cctcctcctc ctcctcctcc tcctcctcct cctcct                                 36


<210>  48
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Inhibitory oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(20)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (22)..(26)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (28)..(29)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (31)..(32)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (34)..(35)
<223>  phosphorothioate-modified

<400>  48
cctcctcctc ctcctcctcc tcctcctcct cctcct                                 36


<210>  49
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Inhibitory oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (4)..(8)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (10)..(14)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (16)..(20)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (22)..(26)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (28)..(32)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (34)..(36)
<223>  phosphorothioate-modified

<400>  49
cctcctcctc ctcctcctcc tcctcctcct cctcct                                 36


<210>  50
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Inhibitory oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(5)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (7)..(11)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (13)..(17)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (19)..(23)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (25)..(29)
<223>  phosphorothioate-modified

<220>
<221>  modified_base
<222>  (31)..(35)
<223>  phosphorothioate-modified

<400>  50
cctcctcctc ctcctcctcc tcctcctcct cctcct                                 36


<210>  51
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MYD 88 forward primer

<400>  51
gttgaagact gggcttgtcc                                                   20


<210>  52
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MYD 88 reverse primer

<400>  52
aggaggcagg gcagaagta                                                    19


