                         SEQUENCE LISTING

<110>  Contrafect Corporation
       Trellis Bioscience, LLC
       Estelles, Angeles
       Kauvar, Lawrence M.
       Vigil, Adam
       Wittekind, Michael
 
<120>  ANTIBODIES USEFUL IN PASSIVE INFLUENZA B IMMUNIZATION, AND 
       COMPOSITIONS, COMBINATIONS AND METHODS FOR USE THEREOF

<130>  4808.1WOU1

<140>  New Filing
<141>  2015-02-04

<150>  US 61/935,746
<151>  2014-02-04

<150>  US 62/051,630
<151>  2014-09-17

<160>  314   

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5A7 HC CDR1

<400>  1

Gly Phe Thr Phe Asn Asn Tyr Gly 
1               5               


<210>  2
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5A7 HC CDR2

<400>  2

Val Trp Tyr Asp Gly Leu Ile Lys 
1               5               


<210>  3
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5A7 HC CDR3

<400>  3

Ala Arg Asp Leu Gln Pro Pro His Ser Pro Tyr Gly Met Asp Val 
1               5                   10                  15  


<210>  4
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5A7 LC CDR1

<400>  4

Ser Ser Asn Ile Gly Ser Asn Asp 
1               5               


<210>  5
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5A7 LC CDR2

<400>  5

Asn Asn Asn 
1           


<210>  6
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5A7 LC CDR3

<400>  6

Ala Ala Trp Asp Asp Ser Leu Thr Val Ser 
1               5                   10  


<210>  7
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5A7 HC

<400>  7

Gln Cys Gln Leu Val Glu Ser Gly Gly Asp Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Val Trp Tyr Asp Gly Leu Ile Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Thr Leu Arg Ala Glu Asp Met Gly Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Gln Pro Pro His Ser Pro Tyr Gly Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  8
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5A7 LC

<400>  8

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Asp Val Tyr Trp Tyr Gln Asn Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asn Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Thr Val Ser Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gln Pro 
            100                 105                 110         


Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
        115                 120                 125             


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
    130                 135                 140                 


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala 
145                 150                 155                 160 


Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
                165                 170                 175     


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
            180                 185                 190         


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
        195                 200                 205             


Val Val Pro Ala Glu Cys Ser 
    210                 215 


<210>  9
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5A7 HCVR

<400>  9

Gln Cys Gln Leu Val Glu Ser Gly Gly Asp Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Val Trp Tyr Asp Gly Leu Ile Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Thr Leu Arg Ala Glu Asp Met Gly Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Gln Pro Pro His Ser Pro Tyr Gly Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  10
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5A7 LCVR

<400>  10

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Asp Val Tyr Trp Tyr Gln Asn Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asn Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Thr Val Ser Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gln 
            100                 105                 110     


<210>  11
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL053 HC CDR1

<400>  11

Gly Gly Ile Ile Arg Lys Tyr Ala 
1               5               


<210>  12
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL053 HC CDR2

<400>  12

Ile Ile Ala Ile Phe Asn Thr Ala 
1               5               


<210>  13
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL053 HC CDR3

<400>  13

Ala Arg Gly Met Asn Tyr Tyr Ser Asp Tyr Phe Asp Tyr 
1               5                   10              


<210>  14
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL053 LC CDR1

<400>  14

Gln Ser Val Arg Ser Asn Asn 
1               5           


<210>  15
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL053 LC CDR2

<400>  15

Gly Ala Ser 
1           


<210>  16
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL053 LC CDR3

<400>  16

Gln Gln Tyr Gly Ser Ser Pro Ala Leu Thr 
1               5                   10  


<210>  17
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL053 HC

<400>  17

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Gly Ile Ile Arg Lys Tyr 
            20                  25                  30          


Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Ala Ile Phe Asn Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Met Asn Tyr Tyr Ser Asp Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Ser Leu Val Thr Val Ser Pro Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  18
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL053 LC

<400>  18

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Asn 
            20                  25                  30          


Asn Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Phe Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Ala Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


<210>  19
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL053 HCVR

<400>  19

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Gly Ile Ile Arg Lys Tyr 
            20                  25                  30          


Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Ala Ile Phe Asn Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Met Asn Tyr Tyr Ser Asp Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Ser Leu Val Thr Val Ser Pro 
        115                 120 


<210>  20
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL053 LCVR

<400>  20

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Asn 
            20                  25                  30          


Asn Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Phe Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Ala Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110     


<210>  21
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL579 HC CDR1

<400>  21

Gly Tyr Thr Phe Thr Ala Tyr Thr 
1               5               


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL579 HC CDR2

<400>  22

Ile Asn Ala Gly Asn Gly His Thr 
1               5               


<210>  23
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL579 HC CDR3

<400>  23

Ala Arg Gly Pro Glu Thr Tyr Tyr Tyr Asp Lys Thr Asn Trp Leu Asn 
1               5                   10                  15      


Ser His Pro Asp Glu Tyr Phe Gln His 
            20                  25  


<210>  24
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL579 LC CDR1

<400>  24

Gln Thr Ile Asn Asn Tyr 
1               5       


<210>  25
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL579 LC CDR2

<400>  25

Lys Ala Ser 
1           


<210>  26
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL579 LC CDR3

<400>  26

Gln Glu Tyr Asn Asn Asp Ser Pro Leu Thr 
1               5                   10  


<210>  27
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL579 HC

<400>  27

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ala Tyr 
            20                  25                  30          


Thr Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ala Gly Asn Gly His Thr Lys Tyr Ser Gln Arg Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Arg Thr Thr Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Leu Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Pro Glu Thr Tyr Tyr Tyr Asp Lys Thr Asn Trp Leu Asn 
            100                 105                 110         


Ser His Pro Asp Glu Tyr Phe Gln His Trp Gly His Gly Thr Gln Val 
        115                 120                 125             


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        195                 200                 205             


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
225                 230                 235                 240 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
                245                 250                 255     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            260                 265                 270         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        275                 280                 285             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    290                 295                 300                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
305                 310                 315                 320 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                325                 330                 335     


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        355                 360                 365             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    370                 375                 380                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
385                 390                 395                 400 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                405                 410                 415     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            420                 425                 430         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        435                 440                 445             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460         


<210>  28
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL579 LC

<400>  28

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Glu Tyr Asn Asn Asp Ser Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  29
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL579 HCVR

<400>  29

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ala Tyr 
            20                  25                  30          


Thr Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ala Gly Asn Gly His Thr Lys Tyr Ser Gln Arg Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Arg Thr Thr Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Leu Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Pro Glu Thr Tyr Tyr Tyr Asp Lys Thr Asn Trp Leu Asn 
            100                 105                 110         


Ser His Pro Asp Glu Tyr Phe Gln His Trp Gly His Gly Thr Gln Val 
        115                 120                 125             


Thr Val Ser Ser 
    130         


<210>  30
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL579 LCVR

<400>  30

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Glu Tyr Asn Asn Asp Ser Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110 


<210>  31
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL784 HC CDR1

<400>  31

Gly Gly Thr Phe Ile Asn Tyr Ala 
1               5               


<210>  32
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL784 HC CDR2

<400>  32

Ile Ile Pro Val Tyr Gly Thr Ser 
1               5               


<210>  33
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL784 HC CDR3

<400>  33

Ala Ala Ser Thr Ala Thr Ser Gly Thr Tyr Tyr Ala Met Arg Pro Phe 
1               5                   10                  15      


Asp Phe 
        


<210>  34
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL784 LC CDR1

<400>  34

Asn Met Gly Pro Thr Ser 
1               5       


<210>  35
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL784 LC CDR2

<400>  35

Asp Asp Ser 
1           


<210>  36
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL784 LC CDR3

<400>  36

Gln Val Trp Asp Met Ser Ser Asp Arg Arg Val 
1               5                   10      


<210>  37
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL784 HC

<400>  37

Gln Val Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Met Ala Thr Gly Gly Thr Phe Ile Asn Tyr 
            20                  25                  30          


Ala Phe Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Gly Ile Ile Pro Val Tyr Gly Thr Ser Asn His Val Glu Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Ala Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Gly Leu Arg Phe Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Ala Ser Thr Ala Thr Ser Gly Thr Tyr Tyr Ala Met Arg Pro Phe 
            100                 105                 110         


Asp Phe Trp Gly Gln Gly Thr Leu Val Ser Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
    210                 215                 220                 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                325                 330                 335     


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Pro Gly Lys 
    450                 455 


<210>  38
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL784 LC

<400>  38

Asp Ile Glu Leu Thr Gln Asp Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Pro Cys Val Arg Phe Asn Met Gly Pro Thr Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr 
        35                  40                  45              


Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asp Ser Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Met Ser Ser Asp Arg 
                85                  90                  95      


Arg Val Phe Gly Gly Gly Thr Thr Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Val Pro Ala Glu Cys Ser 
    210                 


<210>  39
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL784 HCVR

<400>  39

Gln Val Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Met Ala Thr Gly Gly Thr Phe Ile Asn Tyr 
            20                  25                  30          


Ala Phe Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Gly Ile Ile Pro Val Tyr Gly Thr Ser Asn His Val Glu Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Ala Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Gly Leu Arg Phe Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Ala Ser Thr Ala Thr Ser Gly Thr Tyr Tyr Ala Met Arg Pro Phe 
            100                 105                 110         


Asp Phe Trp Gly Gln Gly Thr Leu Val Ser Val Ser Ser 
        115                 120                 125 


<210>  40
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL784 LCVR

<400>  40

Asp Ile Glu Leu Thr Gln Asp Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Pro Cys Val Arg Phe Asn Met Gly Pro Thr Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr 
        35                  40                  45              


Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asp Ser Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Met Ser Ser Asp Arg 
                85                  90                  95      


Arg Val Phe Gly Gly Gly Thr Thr Leu Thr Val Leu Gly Gln 
            100                 105                 110 


<210>  41
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL794 HC CDR1

<400>  41

Gly Phe Thr Phe Arg Ser His Ala 
1               5               


<210>  42
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL794 HC CDR2

<400>  42

Ile Ser Tyr Asp Glu Val Asn Lys 
1               5               


<210>  43
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL794 HC CDR3

<400>  43

Ala Arg Gly His Ser Gly Ser Tyr Arg Leu Phe Asp Phe 
1               5                   10              


<210>  44
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL794 LC CDR1

<400>  44

Gln Val Val Gly Thr Asn 
1               5       


<210>  45
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL794 LC CDR2

<400>  45

Ala Ala Ser 
1           


<210>  46
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL794 LC CDR3

<400>  46

Gln Gln Tyr Asn Asn Trp Pro Leu Ser 
1               5                   


<210>  47
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL794 HC

<400>  47

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser His 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Ser Tyr Asp Glu Val Asn Lys Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Val Ser Lys Asn Thr Val Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Ser Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His Ser Gly Ser Tyr Arg Leu Phe Asp Phe Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  48
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL794 LC

<400>  48

Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Val Val Gly Thr Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Phe Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Leu 
                85                  90                  95      


Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Arg Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  49
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL794 HCVR

<400>  49

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser His 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Ser Tyr Asp Glu Val Asn Lys Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Val Ser Lys Asn Thr Val Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Ser Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His Ser Gly Ser Tyr Arg Leu Phe Asp Phe Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  50
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL794 LCVR

<400>  50

Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Val Val Gly Thr Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Phe Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Leu 
                85                  90                  95      


Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Arg Arg Thr 
            100                 105                 


<210>  51
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL798 HC CDR1

<400>  51

Gly Tyr Asn Phe Ala Ala Tyr Tyr 
1               5               


<210>  52
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL798 HC CDR2

<400>  52

Ser Asn Pro Asn Thr Gly Gly Ala 
1               5               


<210>  53
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL798 HC CDR3

<400>  53

Ala Arg Val Pro Arg Asp Arg Leu Leu Thr Leu Tyr Tyr Glu Ser Ser 
1               5                   10                  15      


Thr Tyr Gly Phe Asp Tyr 
            20          


<210>  54
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL798 LC CDR1

<400>  54

Gln Gly Ile Asn Thr His 
1               5       


<210>  55
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL798 LC CDR2

<400>  55

Ser Ala Ser 
1           


<210>  56
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL798 LC CDR3

<400>  56

Gln Gln Ser Tyr Asn Tyr Pro Arg Thr 
1               5                   


<210>  57
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL798 HC

<400>  57

Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Tyr Asn Phe Ala Ala Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ser Asn Pro Asn Thr Gly Gly Ala Asn Tyr Ala Gln Asp Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Ala Val Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Thr Ser Asp Asp Thr Ala Leu Tyr Phe Cys 
                85                  90                  95      


Ala Arg Val Pro Arg Asp Arg Leu Leu Thr Leu Tyr Tyr Glu Ser Ser 
            100                 105                 110         


Thr Tyr Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
    130                 135                 140                 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
145                 150                 155                 160 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
                165                 170                 175     


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
            180                 185                 190         


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
        195                 200                 205             


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
    210                 215                 220                 


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
225                 230                 235                 240 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
                245                 250                 255     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            260                 265                 270         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        275                 280                 285             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    290                 295                 300                 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
305                 310                 315                 320 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                325                 330                 335     


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            340                 345                 350         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
        355                 360                 365             


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    370                 375                 380                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
385                 390                 395                 400 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                405                 410                 415     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            420                 425                 430         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        435                 440                 445             


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 


<210>  58
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL798 LC

<400>  58

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Val Cys Arg Ala Ser Gln Gly Ile Asn Thr His 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Leu His Thr Gly Val Pro Ser Arg Leu Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Asn Tyr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Asn Val Asp Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  59
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL798 HCVR

<400>  59

Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Tyr Asn Phe Ala Ala Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ser Asn Pro Asn Thr Gly Gly Ala Asn Tyr Ala Gln Asp Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Ala Val Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Thr Ser Asp Asp Thr Ala Leu Tyr Phe Cys 
                85                  90                  95      


Ala Arg Val Pro Arg Asp Arg Leu Leu Thr Leu Tyr Tyr Glu Ser Ser 
            100                 105                 110         


Thr Tyr Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  60
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL798 LCVR

<400>  60

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Val Cys Arg Ala Ser Gln Gly Ile Asn Thr His 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Leu His Thr Gly Val Pro Ser Arg Leu Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Asn Tyr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Asn Val Asp Ile Lys Arg Thr 
            100                 105                 


<210>  61
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL799 HC CDR1

<400>  61

Gly Tyr Thr Leu Ile Asp Tyr Tyr 
1               5               


<210>  62
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL799 HC CDR2

<400>  62

Ile Asn Pro Ile Asn Gly Gly Thr 
1               5               


<210>  63
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL799 HC CDR3

<400>  63

Thr Arg Gly Arg Pro Ile Gly Arg Asn Trp Glu Pro Arg Asp Lys Asp 
1               5                   10                  15      


Tyr 
    


<210>  64
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL799 LC CDR1

<400>  64

Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr 
1               5                   10      


<210>  65
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL799 LC CDR2

<400>  65

Leu Gly Ser 
1           


<210>  66
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL799 LC CDR3

<400>  66

Met Gln Gly Leu Gln Thr Pro Tyr Thr 
1               5                   


<210>  67
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL799 HC

<400>  67

Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Phe Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Leu Ile Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Val Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Ile Asn Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Arg Pro Ile Gly Arg Asn Trp Glu Pro Arg Asp Lys Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Lys 
    450                 


<210>  68
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL799 LC

<400>  68

Asp Ile Glu Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Ser Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Leu Gln Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  69
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL799 HCVR

<400>  69

Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Phe Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Leu Ile Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Val Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Ile Asn Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Arg Pro Ile Gly Arg Asn Trp Glu Pro Arg Asp Lys Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser 
        115                 120                 


<210>  70
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL799 LCVR

<400>  70

Asp Ile Glu Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Ser Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Leu Gln Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr 
        


<210>  71
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL809 HC CDR1

<400>  71

Gly Phe Thr Phe Ser Ala Tyr Ala 
1               5               


<210>  72
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL809 HC CDR2

<400>  72

Thr Ser Tyr Asp Gly Arg Asp Ser 
1               5               


<210>  73
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL809 HC CDR3

<400>  73

Ala Lys Val Gly Pro Tyr Thr Gly Tyr Asp Asp Tyr Asn Tyr Tyr Gly 
1               5                   10                  15      


Met Asp Val 
            


<210>  74
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL809 LC CDR1

<400>  74

Gln Ser Val Leu Ser Asn Ser Lys Asn Leu Asn Tyr 
1               5                   10          


<210>  75
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL809 LC CDR2

<400>  75

Trp Ala Ser 
1           


<210>  76
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL809 LC CDR3

<400>  76

Gln Gln His Tyr Ser Ile Pro Leu Thr 
1               5                   


<210>  77
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL809 HC

<400>  77

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Arg Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ala Cys Ala Gly Ser Gly Phe Thr Phe Ser Ala Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala His Thr Ser Tyr Asp Gly Arg Asp Ser Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Gly Pro Tyr Thr Gly Tyr Asp Asp Tyr Asn Tyr Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly His Gly Thr Thr Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455     


<210>  78
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL809 LC

<400>  78

Asp Ile Val Leu Thr Gln Ser Pro Val Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Ser Ala Thr Val Asn Cys Lys Ser Ser Gln Ser Val Leu Ser Asn 
            20                  25                  30          


Ser Lys Asn Leu Asn Tyr Leu Ala Trp Tyr Gln His Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


His Tyr Ser Ile Pro Leu Thr Phe Gly Pro Gly Thr Lys Val Asp Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  79
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL809 HCVR

<400>  79

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Arg Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ala Cys Ala Gly Ser Gly Phe Thr Phe Ser Ala Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala His Thr Ser Tyr Asp Gly Arg Asp Ser Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Gly Pro Tyr Thr Gly Tyr Asp Asp Tyr Asn Tyr Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly His Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  80
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL809 LCVR

<400>  80

Asp Ile Val Leu Thr Gln Ser Pro Val Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Ser Ala Thr Val Asn Cys Lys Ser Ser Gln Ser Val Leu Ser Asn 
            20                  25                  30          


Ser Lys Asn Leu Asn Tyr Leu Ala Trp Tyr Gln His Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


His Tyr Ser Ile Pro Leu Thr Phe Gly Pro Gly Thr Lys Val Asp Ile 
            100                 105                 110         


Lys Arg Thr 
        115 


<210>  81
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL811 HC CDR1

<400>  81

Gly Phe Thr Phe Thr Asn Tyr Ala 
1               5               


<210>  82
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL811 HC CDR2

<400>  82

Ile Ser Phe Asp Glu Asp Asn Lys 
1               5               


<210>  83
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL811 HC CDR3

<400>  83

Ala Arg Gly Pro Glu Gly Val Trp Gly Arg Ser Ile Asp Ser 
1               5                   10                  


<210>  84
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL811 LC CDR1

<400>  84

Gln Asp Ile Arg Asn Arg 
1               5       


<210>  85
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL811 LC CDR2

<400>  85

Ala Ala Ser 
1           


<210>  86
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL811 LC CDR3

<400>  86

Leu Gln His Asn Ser Tyr Pro Trp Thr 
1               5                   


<210>  87
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL811 HC

<400>  87

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Phe Asp Glu Asp Asn Lys Ser Tyr Ala Asp Tyr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Asn Asn Arg Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Pro Glu Gly Val Trp Gly Arg Ser Ile Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  88
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL811 LC

<400>  88

Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  89
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL811 HCVR

<400>  89

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Phe Asp Glu Asp Asn Lys Ser Tyr Ala Asp Tyr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Asn Asn Arg Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Pro Glu Gly Val Trp Gly Arg Ser Ile Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  90
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL811 LCVR

<400>  90

Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  91
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL812 HC CDR1

<400>  91

Gly Phe Asn Phe Ser Ser Tyr Gly 
1               5               


<210>  92
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL812 HC CDR2

<400>  92

Ile Trp Ser Gly Gly Ser Asn Lys 
1               5               


<210>  93
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL812 HC CDR3

<400>  93

Ala Arg Ala His Thr Ala Leu Thr Arg Phe Arg Trp Leu Asp Pro 
1               5                   10                  15  


<210>  94
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL812 LC CDR1

<400>  94

Gln Gly Ile Gly Ser Asn 
1               5       


<210>  95
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL812 LC CDR2

<400>  95

Ala Ala Ser 
1           


<210>  96
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL812 LC CDR3

<400>  96

Gln Gln Tyr Asn Thr Trp Pro Leu Thr 
1               5                   


<210>  97
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL812 HC

<400>  97

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Ser Val Ile Trp Ser Gly Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala His Thr Ala Leu Thr Arg Phe Arg Trp Leu Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Ile Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  98
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL812 LC

<400>  98

Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Gly Ala Thr Leu Ser Cys Arg Ala Ser Gln Gly Ile Gly Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Tyr Asn Thr Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Ile Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  99
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL812 HCVR

<400>  99

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Ser Val Ile Trp Ser Gly Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala His Thr Ala Leu Thr Arg Phe Arg Trp Leu Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Ile Leu Val Thr Val Ser Ser 
        115                 120         


<210>  100
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL812 LCVR

<400>  100

Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Gly Ala Thr Leu Ser Cys Arg Ala Ser Gln Gly Ile Gly Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Tyr Asn Thr Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Ile Arg Thr 
            100                 105                 


<210>  101
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL813 HC CDR1

<400>  101

Gly Phe Ile Phe Gly Asp Phe Ala 
1               5               


<210>  102
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL813 HC CDR2

<400>  102

Ile Arg Ser Gly Leu Asn Arg Phe Glu Thr 
1               5                   10  


<210>  103
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL813 HC CDR3

<400>  103

Thr Tyr Leu Val Gly Ala Val Gly Phe Gln His 
1               5                   10      


<210>  104
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL813 LC CDR1

<400>  104

Gln Thr Ile Tyr Arg Trp 
1               5       


<210>  105
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL813 LC CDR2

<400>  105

Lys Ala Ser 
1           


<210>  106
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL813 LC CDR3

<400>  106

Gln Gln Tyr Asn Ser Phe Pro Tyr Arg 
1               5                   


<210>  107
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL813 HC

<400>  107

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Gly Asp Phe 
            20                  25                  30          


Ala Ile His Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Gly Leu Asn Arg Phe Glu Thr Ala Tyr Ala Ala 
    50                  55                  60                  


Ser Val Glu Gly Arg Leu Thr Ile Ser Arg Asp Asp Ser Lys Ser Met 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Val Lys Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Leu Cys Thr Tyr Leu Val Gly Ala Val Gly Phe Gln His Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  108
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL813 LC

<400>  108

Asp Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Tyr Arg Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Ala Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Phe Pro Tyr 
                85                  90                  95      


Arg Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  109
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL813 HCVR

<400>  109

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Gly Asp Phe 
            20                  25                  30          


Ala Ile His Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Gly Leu Asn Arg Phe Glu Thr Ala Tyr Ala Ala 
    50                  55                  60                  


Ser Val Glu Gly Arg Leu Thr Ile Ser Arg Asp Asp Ser Lys Ser Met 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Val Lys Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Leu Cys Thr Tyr Leu Val Gly Ala Val Gly Phe Gln His Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  110
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL813 LCVR

<400>  110

Asp Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Tyr Arg Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Ala Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Phe Pro Tyr 
                85                  90                  95      


Arg Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  111
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL823 HC CDR1

<400>  111

Gly Phe Asn Phe Asp Glu Tyr Val 
1               5               


<210>  112
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL823 HC CDR2

<400>  112

Ile Gly Ala Asp Gly Arg Gly Thr 
1               5               


<210>  113
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL823 HC CDR3

<400>  113

Ala Lys Val Glu Arg Ser Phe Tyr Asp Gly Ser Gly Tyr Gly Asp Ala 
1               5                   10                  15      


Leu Glu Ile 
            


<210>  114
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL823 LC CDR1

<400>  114

Gln Thr Ile Thr Arg Phe 
1               5       


<210>  115
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL823 LC CDR2

<400>  115

Ala Ala Ser 
1           


<210>  116
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL823 LC CDR3

<400>  116

Gln Gln Ser Tyr Ser Ala Pro Phe Thr 
1               5                   


<210>  117
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL823 HC

<400>  117

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Phe Asp Glu Tyr 
            20                  25                  30          


Val Met Tyr Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Leu Ile Gly Ala Asp Gly Arg Gly Thr Tyr Asn Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Arg Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ser Asp Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Glu Arg Ser Phe Tyr Asp Gly Ser Gly Tyr Gly Asp Ala 
            100                 105                 110         


Leu Glu Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455     


<210>  118
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL823 LC

<400>  118

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Arg Ala Ser Gln Thr Ile Thr Arg Phe 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Gly Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Val His Arg Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ala Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Thr Val Asp Ile Arg Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  119
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL823 HCVR

<400>  119

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Phe Asp Glu Tyr 
            20                  25                  30          


Val Met Tyr Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Leu Ile Gly Ala Asp Gly Arg Gly Thr Tyr Asn Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Arg Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ser Asp Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Glu Arg Ser Phe Tyr Asp Gly Ser Gly Tyr Gly Asp Ala 
            100                 105                 110         


Leu Glu Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125     


<210>  120
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL823 LCVR

<400>  120

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Arg Ala Ser Gln Thr Ile Thr Arg Phe 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Gly Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Val His Arg Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ala Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Thr Val Asp Ile Arg Arg Thr 
            100                 105                 


<210>  121
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL832 HC CDR1

<400>  121

Gly Gly Ser Val Ser Asn Tyr Tyr 
1               5               


<210>  122
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL832 HC CDR2

<400>  122

Val Phe Tyr Ser Gly Ser Ser Asn Tyr Asn 
1               5                   10  


<210>  123
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL832 HC CDR3

<400>  123

Tyr Cys Ala Arg Gly Arg Val Asn Ser Gly Tyr Asp Trp Gly Pro Asn 
1               5                   10                  15      


Phe Asp Ser 
            


<210>  124
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL832 LC CDR1

<400>  124

Arg Leu Gly Glu Lys Phe 
1               5       


<210>  125
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL832 LC CDR2

<400>  125

Glu Asp Ser 
1           


<210>  126
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL832 LC CDR3

<400>  126

Gln Ala Trp Asp Ser Ser Thr Val Val 
1               5                   


<210>  127
<211>  458
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL832 HC

<400>  127

Gln Val Gln Leu Val Glu Ser Gly Pro Gly Leu Met Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Asn Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Val Phe Tyr Ser Gly Ser Ser Asn Tyr Asn Pro Ser Leu Asn 
    50                  55                  60                  


Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Ile Asp Thr Ser Asn 
65                  70                  75                  80  


Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala 
                85                  90                  95      


Val Tyr Tyr Cys Ala Arg Gly Arg Val Asn Ser Gly Tyr Asp Trp Gly 
            100                 105                 110         


Pro Asn Phe Asp Ser Trp Gly Gln Gly Ala Leu Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
    130                 135                 140                 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
        195                 200                 205             


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
225                 230                 235                 240 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
                245                 250                 255     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            260                 265                 270         


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        275                 280                 285             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    290                 295                 300                 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
305                 310                 315                 320 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                325                 330                 335     


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            340                 345                 350         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
        355                 360                 365             


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    370                 375                 380                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
385                 390                 395                 400 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                405                 410                 415     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            420                 425                 430         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        435                 440                 445             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455             


<210>  128
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL832 LC

<400>  128

Asp Ile Val Leu Thr Gln Ala Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Arg Leu Gly Glu Lys Phe Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Glu Asp Ser Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ile Met 
65                  70                  75                  80  


Asp Glu Gly Asp Phe Phe Cys Gln Ala Trp Asp Ser Ser Thr Val Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala 
            100                 105                 110         


Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn 
        115                 120                 125             


Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val 
    130                 135                 140                 


Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu 
145                 150                 155                 160 


Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser 
                165                 170                 175     


Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser 
            180                 185                 190         


Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Val Pro 
        195                 200                 205             


Ala Glu Cys Ser 
    210         


<210>  129
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL832 HCVR

<400>  129

Gln Val Gln Leu Val Glu Ser Gly Pro Gly Leu Met Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Asn Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Val Phe Tyr Ser Gly Ser Ser Asn Tyr Asn Pro Ser Leu Asn 
    50                  55                  60                  


Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Ile Asp Thr Ser Asn 
65                  70                  75                  80  


Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala 
                85                  90                  95      


Val Tyr Tyr Cys Ala Arg Gly Arg Val Asn Ser Gly Tyr Asp Trp Gly 
            100                 105                 110         


Pro Asn Phe Asp Ser Trp Gly Gln Gly Ala Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  130
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL832 LCVR

<400>  130

Asp Ile Val Leu Thr Gln Ala Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Arg Leu Gly Glu Lys Phe Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Glu Asp Ser Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ile Met 
65                  70                  75                  80  


Asp Glu Gly Asp Phe Phe Cys Gln Ala Trp Asp Ser Ser Thr Val Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105             


<210>  131
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL833 HC CDR1

<400>  131

Gly Ala Ser Ile Ser Thr Gly Gly Asn Tyr 
1               5                   10  


<210>  132
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL833 HC CDR2

<400>  132

Ile Phe Tyr Ser Gly Thr Thr Lys Tyr Asn 
1               5                   10  


<210>  133
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL833 HC CDR3

<400>  133

Phe Cys Ala Arg Gly Ser Pro Asn Ser Gly Tyr Asp Trp Gly Pro His 
1               5                   10                  15      


Phe Asp Tyr 
            


<210>  134
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL833 LC CDR1

<400>  134

Lys Leu Gly Asp Lys Phe 
1               5       


<210>  135
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL833 LC CDR2

<400>  135

Gln Asp Asp 
1           


<210>  136
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL833 LC CDR3

<400>  136

Gln Ala Trp Asp Ser Thr Thr Val Val 
1               5                   


<210>  137
<211>  460
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL833 HC

<400>  137

Gln Val Gln Leu Leu Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Leu Leu Thr Cys Thr Val Ser Gly Ala Ser Ile Ser Thr Gly 
            20                  25                  30          


Gly Asn Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Asp Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Phe Tyr Ser Gly Thr Thr Lys Tyr Asn Pro Ser 
    50                  55                  60                  


Val Asp Asn Pro Ser Leu Lys Ser Arg Val Thr Met Ser Val Asp Thr 
65                  70                  75                  80  


Ser Glu Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
                85                  90                  95      


Thr Ala Val Tyr Phe Cys Ala Arg Gly Ser Pro Asn Ser Gly Tyr Asp 
            100                 105                 110         


Trp Gly Pro His Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
    130                 135                 140                 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
145                 150                 155                 160 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
                165                 170                 175     


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
            180                 185                 190         


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
        195                 200                 205             


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
    210                 215                 220                 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
225                 230                 235                 240 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
                245                 250                 255     


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            260                 265                 270         


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        275                 280                 285             


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    290                 295                 300                 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
305                 310                 315                 320 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                325                 330                 335     


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
            340                 345                 350         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
        355                 360                 365             


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    370                 375                 380                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
385                 390                 395                 400 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                405                 410                 415     


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            420                 425                 430         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        435                 440                 445             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460 


<210>  138
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL833 LC

<400>  138

Asp Ile Glu Leu Thr Gln Ser Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys Leu Gly Asp Lys Phe Val 
            20                  25                  30          


Cys Trp Tyr Gln Gln Lys Ala Gly Gln Ser Pro Ile Val Val Ile Tyr 
        35                  40                  45              


Gln Asp Asp Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Phe Cys Gln Ala Trp Asp Ser Thr Thr Val Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala 
            100                 105                 110         


Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn 
        115                 120                 125             


Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val 
    130                 135                 140                 


Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu 
145                 150                 155                 160 


Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser 
                165                 170                 175     


Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser 
            180                 185                 190         


Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Val Pro 
        195                 200                 205             


Ala Glu Cys Ser 
    210         


<210>  139
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL833 HCVR

<400>  139

Gln Val Gln Leu Leu Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Leu Leu Thr Cys Thr Val Ser Gly Ala Ser Ile Ser Thr Gly 
            20                  25                  30          


Gly Asn Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Asp Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Phe Tyr Ser Gly Thr Thr Lys Tyr Asn Pro Ser 
    50                  55                  60                  


Val Asp Asn Pro Ser Leu Lys Ser Arg Val Thr Met Ser Val Asp Thr 
65                  70                  75                  80  


Ser Glu Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
                85                  90                  95      


Thr Ala Val Tyr Phe Cys Ala Arg Gly Ser Pro Asn Ser Gly Tyr Asp 
            100                 105                 110         


Trp Gly Pro His Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  140
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL833 LCVR

<400>  140

Asp Ile Glu Leu Thr Gln Ser Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys Leu Gly Asp Lys Phe Val 
            20                  25                  30          


Cys Trp Tyr Gln Gln Lys Ala Gly Gln Ser Pro Ile Val Val Ile Tyr 
        35                  40                  45              


Gln Asp Asp Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Phe Cys Gln Ala Trp Asp Ser Thr Thr Val Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105             


<210>  141
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL834 HC CDR1

<400>  141

Gly Gly Thr Phe Ser Tyr Tyr Ala 
1               5               


<210>  142
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL834 HC CDR2

<400>  142

Ile Ile Pro Ile Val Gly Thr Ala 
1               5               


<210>  143
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL834 HC CDR3

<400>  143

Ala Arg Ala Ala Asp Glu Ser Val Glu Ser Leu Thr Ile Lys Ala Phe 
1               5                   10                  15      


Arg Thr Asn Tyr His 
            20      


<210>  144
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL834 LC CDR1

<400>  144

Thr Ser Asn Ile Gly Ser Asn Thr 
1               5               


<210>  145
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL834 LC CDR2

<400>  145

Thr Asp Asn 
1           


<210>  146
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL834 LC CDR3

<400>  146

Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 
1               5                   10      


<210>  147
<211>  458
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL834 HC

<400>  147

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Tyr Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Val Gly Thr Ala His Tyr Thr Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ala Ala Asp Glu Ser Val Glu Ser Leu Thr Ile Lys Ala Phe 
            100                 105                 110         


Arg Thr Asn Tyr His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
    130                 135                 140                 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
        195                 200                 205             


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
225                 230                 235                 240 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
                245                 250                 255     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            260                 265                 270         


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        275                 280                 285             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    290                 295                 300                 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
305                 310                 315                 320 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                325                 330                 335     


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            340                 345                 350         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
        355                 360                 365             


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    370                 375                 380                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
385                 390                 395                 400 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                405                 410                 415     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            420                 425                 430         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        435                 440                 445             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455             


<210>  148
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL834 LC

<400>  148

Asp Ile Glu Leu Thr Gln Glu Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Asp Thr Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Ser Trp Phe Gln Leu Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Phe Thr Asp Asn Gln Arg Pro Ser Gly Val Pro Gly Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Thr Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Val Pro Ala Glu Cys Ser 
    210                 215     


<210>  149
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL834 HCVR

<400>  149

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Tyr Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Val Gly Thr Ala His Tyr Thr Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ala Ala Asp Glu Ser Val Glu Ser Leu Thr Ile Lys Ala Phe 
            100                 105                 110         


Arg Thr Asn Tyr His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  150
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL834 LCVR

<400>  150

Asp Ile Glu Leu Thr Gln Glu Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Asp Thr Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Ser Trp Phe Gln Leu Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Phe Thr Asp Asn Gln Arg Pro Ser Gly Val Pro Gly Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Thr Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


<210>  151
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL835 HC CDR1

<400>  151

Gly Tyr Asn Phe Pro Lys Tyr Trp 
1               5               


<210>  152
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL835 HC CDR2

<400>  152

Ile Tyr Pro Gly Asp Ser Asp Val 
1               5               


<210>  153
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL835 HC CDR3

<400>  153

Ala Arg His Leu Gly Gln Gln Leu Val Ser Asn Thr Tyr Tyr Tyr Tyr 
1               5                   10                  15      


Gly Met Asp Val 
            20  


<210>  154
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL835 LC CDR1

<400>  154

Gln Ser Leu Leu Asp Ser Asn Gly Tyr Asn Tyr 
1               5                   10      


<210>  155
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL835 LC CDR2

<400>  155

Leu Ala Ser 
1           


<210>  156
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL835 LC CDR3

<400>  156

Met Gln Ala Leu Gln Thr Pro Pro Met Tyr Thr 
1               5                   10      


<210>  157
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL835 HC

<400>  157

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Arg Gly Ser Gly Tyr Asn Phe Pro Lys Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Met Ile Tyr Pro Gly Asp Ser Asp Val Arg Tyr Asn Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Glu Ser Ile Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Arg Thr Ser Asp Thr Ala Arg Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Leu Gly Gln Gln Leu Val Ser Asn Thr Tyr Tyr Tyr Tyr 
            100                 105                 110         


Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  158
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL835 LC

<400>  158

Asp Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Ala Ser Tyr Arg Ala Pro Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Leu Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Pro Met Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu 
            100                 105                 110         


Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 
        115                 120                 125             


Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn 
    130                 135                 140                 


Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 
145                 150                 155                 160 


Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 
                165                 170                 175     


Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 
            180                 185                 190         


Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 
        195                 200                 205             


Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220     


<210>  159
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL835 HCVR

<400>  159

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Arg Gly Ser Gly Tyr Asn Phe Pro Lys Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Met Ile Tyr Pro Gly Asp Ser Asp Val Arg Tyr Asn Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Glu Ser Ile Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Arg Thr Ser Asp Thr Ala Arg Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Leu Gly Gln Gln Leu Val Ser Asn Thr Tyr Tyr Tyr Tyr 
            100                 105                 110         


Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         


<210>  160
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL835 LCVR

<400>  160

Asp Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Ala Ser Tyr Arg Ala Pro Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Leu Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Pro Met Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu 
            100                 105                 110         


Ile Lys Arg Thr 
        115     


<210>  161
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL837 HC CDR1

<400>  161

Gly His Thr Phe Ile Ser Tyr Ala 
1               5               


<210>  162
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL837 HC CDR2

<400>  162

Ile Val Pro Ile Phe Gly Thr Val 
1               5               


<210>  163
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL837 HC CDR3

<400>  163

Ala Arg Glu Ala Gly Tyr His Ser Ser Phe Ser Gly Val Tyr Phe Asp 
1               5                   10                  15      


Tyr 
    


<210>  164
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL837 LC CDR1

<400>  164

Gln Ser Val Arg Ser Gly Tyr 
1               5           


<210>  165
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL837 LC CDR2

<400>  165

Asp Ala Ser 
1           


<210>  166
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL837 LC CDR3

<400>  166

Leu Gln Tyr Gly Ser Ser Pro Arg Thr 
1               5                   


<210>  167
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL837 HC

<400>  167

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Thr Val Ser Cys Lys Thr Ser Gly His Thr Phe Ile Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Leu Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Val Pro Ile Phe Gly Thr Val Asn Tyr Thr Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Leu Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Ser Arg Leu Thr Phe Glu Asp Thr Ala Ile Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Ala Gly Tyr His Ser Ser Phe Ser Gly Val Tyr Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Leu Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Lys 
    450                 


<210>  168
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL837 LC

<400>  168

Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Tyr Cys Arg Ala Ser Gln Ser Val Arg Ser Gly 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Leu Leu Leu 
        35                  40                  45              


Phe Tyr Asp Ala Ser Gly Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  169
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL837 HCVR

<400>  169

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Thr Val Ser Cys Lys Thr Ser Gly His Thr Phe Ile Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Leu Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Val Pro Ile Phe Gly Thr Val Asn Tyr Thr Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Leu Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Ser Arg Leu Thr Phe Glu Asp Thr Ala Ile Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Ala Gly Tyr His Ser Ser Phe Ser Gly Val Tyr Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Leu Thr Val Ser Ser 
        115                 120                 


<210>  170
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL837 LCVR

<400>  170

Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Tyr Cys Arg Ala Ser Gln Ser Val Arg Ser Gly 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Leu Leu Leu 
        35                  40                  45              


Phe Tyr Asp Ala Ser Gly Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110 


<210>  171
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL839 HC CDR1

<400>  171

Gly Phe Thr Phe Arg Thr Tyr Gly 
1               5               


<210>  172
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL839 HC CDR2

<400>  172

Ile Ser Tyr Asp Gly Thr Asn Lys 
1               5               


<210>  173
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL839 HC CDR3

<400>  173

Ala Ser Leu Asp Tyr Asp Phe Ser Tyr Tyr Tyr His Arg Asp Val 
1               5                   10                  15  


<210>  174
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL839 LC CDR1

<400>  174

Ser Ser Asp Val Gly Gly Tyr Asp Tyr 
1               5                   


<210>  175
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL839 LC CDR2

<400>  175

Glu Val Arg 
1           


<210>  176
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL839 LC CDR3

<400>  176

Ala Ser Tyr Ala Gly Thr Tyr Ile His Leu 
1               5                   10  


<210>  177
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL839 HC

<400>  177

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Arg Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Thr Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Cys Val 
        35                  40                  45              


Ala Leu Ile Ser Tyr Asp Gly Thr Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asp Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Leu Asp Tyr Asp Phe Ser Tyr Tyr Tyr His Arg Asp Val Trp 
            100                 105                 110         


Gly Pro Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  178
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL839 LC

<400>  178

Asp Ile Val Leu Thr Gln Ser Pro Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asp Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Arg Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Tyr Tyr Tyr Cys Ala Ser Tyr Ala Gly Thr 
                85                  90                  95      


Tyr Ile His Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Val Pro Ala Glu Cys Ser 
    210                 215     


<210>  179
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL839 HCVR

<400>  179

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Arg Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Thr Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Cys Val 
        35                  40                  45              


Ala Leu Ile Ser Tyr Asp Gly Thr Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asp Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Leu Asp Tyr Asp Phe Ser Tyr Tyr Tyr His Arg Asp Val Trp 
            100                 105                 110         


Gly Pro Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  180
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL839 LCVR

<400>  180

Asp Ile Val Leu Thr Gln Ser Pro Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asp Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Arg Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Tyr Tyr Tyr Cys Ala Ser Tyr Ala Gly Thr 
                85                  90                  95      


Tyr Ile His Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


<210>  181
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL841 HC CDR1

<400>  181

Gly Phe Thr Phe Ser Ser Tyr Gly 
1               5               


<210>  182
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL841 HC CDR2

<400>  182

Ile Ser Tyr Asp Glu Ile Asn Lys 
1               5               


<210>  183
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL841 HC CDR3

<400>  183

Ala Lys Pro Leu Arg Gly Ser Tyr Arg Tyr Phe Asp Leu 
1               5                   10              


<210>  184
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL841 LC CDR1

<400>  184

Gln Gly Leu Gly Ser Asn 
1               5       


<210>  185
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL841 LC CDR2

<400>  185

Ala Ala Ser 
1           


<210>  186
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL841 LC CDR3

<400>  186

Gln Gln Tyr Thr Tyr Trp Pro Leu Thr 
1               5                   


<210>  187
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL841 HC

<400>  187

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Ile Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Ser Tyr Asp Glu Ile Asn Lys Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Pro Leu Arg Gly Ser Tyr Arg Tyr Phe Asp Leu Trp Gly Arg 
            100                 105                 110         


Gly Thr Val Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  188
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL841 LC

<400>  188

Asp Ile Val Met Thr Gln Pro Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Gly Ala Ser Gln Gly Leu Gly Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Arg Ala Thr Gly Ile Thr Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Asn Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Leu Tyr Tyr Cys Gln Gln Tyr Thr Tyr Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  189
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL841 HCVR

<400>  189

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Ile Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Ser Tyr Asp Glu Ile Asn Lys Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Pro Leu Arg Gly Ser Tyr Arg Tyr Phe Asp Leu Trp Gly Arg 
            100                 105                 110         


Gly Thr Val Val Thr Val Ser Ser 
        115                 120 


<210>  190
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL841 LCVR

<400>  190

Asp Ile Val Met Thr Gln Pro Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Gly Ala Ser Gln Gly Leu Gly Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Arg Ala Thr Gly Ile Thr Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Asn Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Leu Tyr Tyr Cys Gln Gln Tyr Thr Tyr Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  191
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL842 HC CDR1

<400>  191

Gly Phe Ser Leu Trp Thr Ser Gly 
1               5               


<210>  192
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL842 HC CDR2

<400>  192

Met Ser Tyr Asp Glu Thr Lys Lys 
1               5               


<210>  193
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL842 HC CDR3

<400>  193

Ala Lys Pro Arg Leu Asp Tyr Leu Asp Tyr Phe His Ala Ala Asp Ser 
1               5                   10                  15      


<210>  194
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL842 LC CDR1

<400>  194

Tyr Ile Gly Ser Lys Ser 
1               5       


<210>  195
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL842 LC CDR2

<400>  195

Asp Asp Ser 
1           


<210>  196
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL842 LC CDR3

<400>  196

Cys Gln Val Trp Glu Thr Ser Glu Asp Leu Trp Val 
1               5                   10          


<210>  197
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL842 HC

<400>  197

Gln Val Gln Leu Leu Glu Ser Gly Gly Asp Val Val Gln Pro Gly Thr 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Trp Thr Ser 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Met Ser Tyr Asp Glu Thr Lys Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Ser Ile Ser Arg Asp Asn Ser Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Lys Pro Arg Leu Asp Tyr Leu Asp Tyr Phe His Ala Ala Asp Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Ser Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  198
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL842 LC

<400>  198

Asp Ile Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Thr Ile Thr Cys Gly Gly Asn Tyr Ile Gly Ser Lys Ser Val 
            20                  25                  30          


Asn Trp Tyr Gln Gln Arg Pro Gly His Ala Pro Val Leu Val Val Tyr 
        35                  40                  45              


Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Arg Ser Thr Ala Thr Thr Ala Thr Leu Thr Ile Ser Arg Val 
65                  70                  75                  80  


Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Glu Thr Ser 
                85                  90                  95      


Glu Asp Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Val Pro Ala Glu Cys Ser 
    210                 215         


<210>  199
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL842 HCVR

<400>  199

Gln Val Gln Leu Leu Glu Ser Gly Gly Asp Val Val Gln Pro Gly Thr 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Trp Thr Ser 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Met Ser Tyr Asp Glu Thr Lys Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Ser Ile Ser Arg Asp Asn Ser Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Lys Pro Arg Leu Asp Tyr Leu Asp Tyr Phe His Ala Ala Asp Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Ser Val Ser Ser 
        115                 120             


<210>  200
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL842 LCVR

<400>  200

Asp Ile Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Thr Ile Thr Cys Gly Gly Asn Tyr Ile Gly Ser Lys Ser Val 
            20                  25                  30          


Asn Trp Tyr Gln Gln Arg Pro Gly His Ala Pro Val Leu Val Val Tyr 
        35                  40                  45              


Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Arg Ser Thr Ala Thr Thr Ala Thr Leu Thr Ile Ser Arg Val 
65                  70                  75                  80  


Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Glu Thr Ser 
                85                  90                  95      


Glu Asp Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln 
    


<210>  201
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL845 HC CDR1

<400>  201

Gly Phe Thr Phe Ser Arg Tyr Ser 
1               5               


<210>  202
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL845 HC CDR2

<400>  202

Ile Ser Asp Thr Ser Arg Thr Ile 
1               5               


<210>  203
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL845 HC CDR3

<400>  203

Ala Arg Asp Pro Asp Thr Pro Phe Val Arg Ala Phe Asp Ser 
1               5                   10                  


<210>  204
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL845 LC CDR1

<400>  204

Gln Leu Ile Ser Ser Tyr 
1               5       


<210>  205
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL845 LC CDR2

<400>  205

Ala Ala Ser 
1           


<210>  206
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL845 LC CDR3

<400>  206

Gln Gln Leu Asn Ser Tyr Pro Pro Ile Thr 
1               5                   10  


<210>  207
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL845 HC

<400>  207

Gln Val Gln Leu Val Gln Ser Gly Gly Asp Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Met Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Asp Thr Ser Arg Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Lys Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Asp Thr Pro Phe Val Arg Ala Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  208
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL845 LC

<400>  208

Asp Ile Val Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Leu Ile Ser Ser Tyr 
            20                  25                  30          


Phe Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Ser Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  209
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL845 HCVR

<400>  209

Gln Val Gln Leu Val Gln Ser Gly Gly Asp Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Met Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Asp Thr Ser Arg Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Lys Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Asp Thr Pro Phe Val Arg Ala Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  210
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL845 LCVR

<400>  210

Asp Ile Val Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Leu Ile Ser Ser Tyr 
            20                  25                  30          


Phe Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Ser Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr 
            100                 105                 110 


<210>  211
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL846 HC CDR1

<400>  211

Gly Phe Thr Phe Asn Ser Tyr Ala 
1               5               


<210>  212
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL846 HC CDR2

<400>  212

Ile Arg Gly Ser Gly Glu Asn Thr 
1               5               


<210>  213
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL846 HC CDR3

<400>  213

Ala Arg Lys Trp Gly Arg Met Thr Val Phe Gly Val Ala Thr Asp Gln 
1               5                   10                  15      


Leu Tyr Tyr Phe Asp Tyr 
            20          


<210>  214
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL846 LC CDR1

<400>  214

Gln Ser Val Ser Ser Asn 
1               5       


<210>  215
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL846 LC CDR2

<400>  215

Gly Ala Ser 
1           


<210>  216
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL846 LC CDR3

<400>  216

Gln Gln Phe Asn Asp Trp Pro Phe Leu Thr 
1               5                   10  


<210>  217
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL846 HC

<400>  217

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Val Ser Gly Phe Thr Phe Asn Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Arg Gly Ser Gly Glu Asn Thr Tyr Tyr Ala Glu Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Glu Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Lys Trp Gly Arg Met Thr Val Phe Gly Val Ala Thr Asp Gln 
            100                 105                 110         


Leu Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
    130                 135                 140                 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
145                 150                 155                 160 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
                165                 170                 175     


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
            180                 185                 190         


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
        195                 200                 205             


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
    210                 215                 220                 


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
225                 230                 235                 240 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
                245                 250                 255     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            260                 265                 270         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        275                 280                 285             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    290                 295                 300                 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
305                 310                 315                 320 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                325                 330                 335     


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            340                 345                 350         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
        355                 360                 365             


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    370                 375                 380                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
385                 390                 395                 400 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                405                 410                 415     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            420                 425                 430         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        435                 440                 445             


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 


<210>  218
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL846 LC

<400>  218

Asp Ile Thr Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Arg Ala Thr Asp Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Phe Asn Asp Trp Pro Phe 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  219
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL846 HCVR

<400>  219

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Val Ser Gly Phe Thr Phe Asn Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Arg Gly Ser Gly Glu Asn Thr Tyr Tyr Ala Glu Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Glu Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Lys Trp Gly Arg Met Thr Val Phe Gly Val Ala Thr Asp Gln 
            100                 105                 110         


Leu Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  220
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL846 LCVR

<400>  220

Asp Ile Thr Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Arg Ala Thr Asp Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Phe Asn Asp Trp Pro Phe 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110 


<210>  221
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL847 HC CDR1

<400>  221

Gly Phe Thr Phe Ser Arg Phe Ser 
1               5               


<210>  222
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL847 HC CDR2

<400>  222

Ile Ser Asp Thr Gly Arg Thr Ile 
1               5               


<210>  223
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL847 HC CDR3

<400>  223

Ala Arg Asp Pro Asp Thr Pro Phe Val Arg Ala Phe Asp Ser 
1               5                   10                  


<210>  224
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL847 LC CDR1

<400>  224

Gln Val Ile Ser Ser Tyr 
1               5       


<210>  225
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL847 LC CDR2

<400>  225

Ala Ala Ser 
1           


<210>  226
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL847 LC CDR3

<400>  226

Gln Gln Leu Thr Thr Tyr Pro Pro Ile Thr 
1               5                   10  


<210>  227
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL847 HC

<400>  227

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Arg Phe 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Met Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Asp Thr Gly Arg Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Asp Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Lys Ser Leu Arg Asp Glu Asp Ser Ala Phe Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Asp Thr Pro Phe Val Arg Ala Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Val Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  228
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL847 LC

<400>  228

Asp Ile Val Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Gln Val Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Arg Phe Ser Leu Thr Ile Ser Asn Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Leu Thr Thr Tyr Pro Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  229
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL847 HCVR

<400>  229

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Arg Phe 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Met Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Asp Thr Gly Arg Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Asp Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Lys Ser Leu Arg Asp Glu Asp Ser Ala Phe Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Asp Thr Pro Phe Val Arg Ala Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Val Leu Val Thr Val Ser Ser 
        115                 120     


<210>  230
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL847 LCVR

<400>  230

Asp Ile Val Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Gln Val Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Arg Phe Ser Leu Thr Ile Ser Asn Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Leu Thr Thr Tyr Pro Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr 
            100                 105                 110 


<210>  231
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL848 HC CDR1

<400>  231

Gly Phe Ser Leu Trp Thr Ser Gly 
1               5               


<210>  232
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL848 HC CDR2

<400>  232

Met Ser Tyr Asp Glu Thr Lys Lys 
1               5               


<210>  233
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL848 HC CDR3

<400>  233

Ala Lys Pro Arg Leu Asp Tyr Leu Asp Tyr Phe His Ala Ala Asp Ser 
1               5                   10                  15      


<210>  234
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL848 LC CDR1

<400>  234

Tyr Ile Gly Ser Lys Ser 
1               5       


<210>  235
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL848 LC CDR2

<400>  235

Asp Asp Ser 
1           


<210>  236
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL848 LC CDR3

<400>  236

Cys Gln Val Trp Glu Thr Ser Glu Asp Leu Trp Val 
1               5                   10          


<210>  237
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL848 HC

<400>  237

Gln Val Gln Leu Leu Glu Ser Gly Gly Asp Val Val Gln Pro Gly Thr 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Trp Thr Ser 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Met Ser Tyr Asp Glu Thr Lys Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Ser Ile Ser Arg Asp Asn Ser Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Lys Pro Arg Leu Asp Tyr Leu Asp Tyr Phe His Ala Ala Asp Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Ser Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  238
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL848 LC

<400>  238

Asp Ile Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Thr Ile Thr Cys Gly Gly Asn Tyr Ile Gly Ser Lys Ser Val 
            20                  25                  30          


Asn Trp Tyr Gln Gln Arg Pro Gly His Ala Pro Val Leu Val Val Tyr 
        35                  40                  45              


Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Arg Ser Thr Ala Thr Thr Ala Thr Leu Thr Ile Ser Arg Val 
65                  70                  75                  80  


Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Glu Thr Ser 
                85                  90                  95      


Glu Asp Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Val Pro Ala Glu Cys Ser 
    210                 215         


<210>  239
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL848 HCVR

<400>  239

Gln Val Gln Leu Leu Glu Ser Gly Gly Asp Val Val Gln Pro Gly Thr 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Trp Thr Ser 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Met Ser Tyr Asp Glu Thr Lys Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Ser Ile Ser Arg Asp Asn Ser Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Lys Pro Arg Leu Asp Tyr Leu Asp Tyr Phe His Ala Ala Asp Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Ser Val Ser Ser 
        115                 120             


<210>  240
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL848 LCVR

<400>  240

Asp Ile Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Thr Ile Thr Cys Gly Gly Asn Tyr Ile Gly Ser Lys Ser Val 
            20                  25                  30          


Asn Trp Tyr Gln Gln Arg Pro Gly His Ala Pro Val Leu Val Val Tyr 
        35                  40                  45              


Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Arg Ser Thr Ala Thr Thr Ala Thr Leu Thr Ile Ser Arg Val 
65                  70                  75                  80  


Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Glu Thr Ser 
                85                  90                  95      


Glu Asp Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln 
    


<210>  241
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL849 HC CDR1

<400>  241

Gly Gly Ser Ile Ser Asn Gly Gly Tyr His 
1               5                   10  


<210>  242
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL849 HC CDR2

<400>  242

Ile Tyr Tyr Arg Gly Ser Thr 
1               5           


<210>  243
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL849 HC CDR3

<400>  243

Ala Arg Met Pro Leu Ala Asn Tyr Asp Leu Leu Thr Gly Leu Tyr Ile 
1               5                   10                  15      


Gly Ala Phe Asp Leu 
            20      


<210>  244
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL849 LC CDR1

<400>  244

Gln Ser Val Asn Arg Asn 
1               5       


<210>  245
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL849 LC CDR2

<400>  245

Asp Ala Ser 
1           


<210>  246
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL849 LC CDR3

<400>  246

Gln Gln Tyr Asp Lys Trp Pro Pro Gly 
1               5                   


<210>  247
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL849 HC

<400>  247

Gln Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Asn Gly 
            20                  25                  30          


Gly Tyr His Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Asn Ile Tyr Tyr Arg Gly Ser Thr Phe Tyr Asp Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Met Pro Leu Ala Asn Tyr Asp Leu Leu Thr Gly Leu Tyr 
            100                 105                 110         


Ile Gly Ala Phe Asp Leu Trp Gly Gln Gly Thr Met Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
    130                 135                 140                 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
145                 150                 155                 160 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
                165                 170                 175     


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
            180                 185                 190         


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
        195                 200                 205             


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
    210                 215                 220                 


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
225                 230                 235                 240 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
                245                 250                 255     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            260                 265                 270         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        275                 280                 285             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    290                 295                 300                 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
305                 310                 315                 320 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                325                 330                 335     


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            340                 345                 350         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
        355                 360                 365             


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    370                 375                 380                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
385                 390                 395                 400 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                405                 410                 415     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            420                 425                 430         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        435                 440                 445             


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 


<210>  248
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL849 LC

<400>  248

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asn Arg Asn 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Ile Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Phe Asp Ala Ser Thr Arg Ala Ala Asp Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Gly Gly Ser Gly Ala Glu Phe Thr Leu Thr Val Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Lys Trp Pro Pro 
                85                  90                  95      


Gly Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  249
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL849 HCVR

<400>  249

Gln Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Asn Gly 
            20                  25                  30          


Gly Tyr His Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Asn Ile Tyr Tyr Arg Gly Ser Thr Phe Tyr Asp Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Met Pro Leu Ala Asn Tyr Asp Leu Leu Thr Gly Leu Tyr 
            100                 105                 110         


Ile Gly Ala Phe Asp Leu Trp Gly Gln Gly Thr Met Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  250
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL849 LCVR

<400>  250

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asn Arg Asn 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Ile Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Phe Asp Ala Ser Thr Arg Ala Ala Asp Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Gly Gly Ser Gly Ala Glu Phe Thr Leu Thr Val Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Lys Trp Pro Pro 
                85                  90                  95      


Gly Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  251
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL851 HC CDR1

<400>  251

Gly Asp Ser Phe Thr Ser Tyr Trp 
1               5               


<210>  252
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL851 HC CDR2

<400>  252

Ile Tyr Pro Arg Asp Ser Glu Thr 
1               5               


<210>  253
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL851 HC CDR3

<400>  253

Ala Arg Ser Pro Gly Tyr Ser Gly Tyr Leu Tyr Gly Trp Phe Asp Pro 
1               5                   10                  15      


<210>  254
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL851 LC CDR1

<400>  254

Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr 
1               5                   10      


<210>  255
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL851 LC CDR2

<400>  255

Leu Gly Ser 
1           


<210>  256
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL851 LC CDR3

<400>  256

Met Gln Gly Leu Gln Thr Pro Tyr Thr 
1               5                   


<210>  257
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL851 HC

<400>  257

Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Arg Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Ala His Gly Asp Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Leu Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Ala Val Ile Tyr Pro Arg Asp Ser Glu Thr Lys Phe Ser Pro Ala Phe 
    50                  55                  60                  


His Gly Gln Val Ser Ile Ser Val Asp Lys Ser Thr Ser Thr Val His 
65                  70                  75                  80  


Leu Gln Trp Asn Ser Leu Lys Ala Ser Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Pro Gly Tyr Ser Gly Tyr Leu Tyr Gly Trp Phe Asp Pro 
            100                 105                 110         


Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  258
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL851 LC

<400>  258

Asp Ile Glu Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Ser Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Leu Gln Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  259
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL851 HCVR

<400>  259

Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Arg Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Ala His Gly Asp Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Leu Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Ala Val Ile Tyr Pro Arg Asp Ser Glu Thr Lys Phe Ser Pro Ala Phe 
    50                  55                  60                  


His Gly Gln Val Ser Ile Ser Val Asp Lys Ser Thr Ser Thr Val His 
65                  70                  75                  80  


Leu Gln Trp Asn Ser Leu Lys Ala Ser Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Pro Gly Tyr Ser Gly Tyr Leu Tyr Gly Trp Phe Asp Pro 
            100                 105                 110         


Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser 
        115                 120             


<210>  260
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL851 LCVR

<400>  260

Asp Ile Glu Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Ser Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Leu Gln Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr 
        


<210>  261
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL854 HC CDR1

<400>  261

Gly Tyr Thr Phe Thr Ala Tyr His 
1               5               


<210>  262
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL854 HC CDR2

<400>  262

Ile Asn Pro Asn Ser Gly Ala Thr 
1               5               


<210>  263
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL854 HC CDR3

<400>  263

Ala Thr Asp Ile Val Val Glu Arg Asp Ala Ser Leu Gly Gly Phe Asn 
1               5                   10                  15      


Ser Tyr Gly Met Asp Val 
            20          


<210>  264
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL854 LC CDR1

<400>  264

Gln Ser Leu Leu His Ser Asn Gly Tyr Asn His 
1               5                   10      


<210>  265
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL854 LC CDR2

<400>  265

Leu Ala Ser 
1           


<210>  266
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL854 LC CDR3

<400>  266

Met Gln Ser Leu Gln Thr Ser Ile Thr 
1               5                   


<210>  267
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL854 HC

<400>  267

Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Ala Tyr 
            20                  25                  30          


His Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Phe Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Ala Thr Tyr Tyr Thr Ser Thr Phe 
    50                  55                  60                  


Glu Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asp Ile Val Val Glu Arg Asp Ala Ser Leu Gly Gly Phe Asn 
            100                 105                 110         


Ser Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
    130                 135                 140                 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
145                 150                 155                 160 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
                165                 170                 175     


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
            180                 185                 190         


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
        195                 200                 205             


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
    210                 215                 220                 


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
225                 230                 235                 240 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
                245                 250                 255     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            260                 265                 270         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        275                 280                 285             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    290                 295                 300                 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
305                 310                 315                 320 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                325                 330                 335     


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            340                 345                 350         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
        355                 360                 365             


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    370                 375                 380                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
385                 390                 395                 400 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                405                 410                 415     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            420                 425                 430         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        435                 440                 445             


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 


<210>  268
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL854 LC

<400>  268

Asp Ile Glu Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn His Leu Ala Trp Tyr Leu Gln Lys Pro Gly Arg Ser 
        35                  40                  45              


Pro His Leu Leu Ile Tyr Leu Ala Ser Thr Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln Ser 
                85                  90                  95      


Leu Gln Thr Ser Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  269
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL854 HCVR

<400>  269

Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Ala Tyr 
            20                  25                  30          


His Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Phe Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Ala Thr Tyr Tyr Thr Ser Thr Phe 
    50                  55                  60                  


Glu Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asp Ile Val Val Glu Arg Asp Ala Ser Leu Gly Gly Phe Asn 
            100                 105                 110         


Ser Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  270
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL854 LCVR

<400>  270

Asp Ile Glu Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn His Leu Ala Trp Tyr Leu Gln Lys Pro Gly Arg Ser 
        35                  40                  45              


Pro His Leu Leu Ile Tyr Leu Ala Ser Thr Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln Ser 
                85                  90                  95      


Leu Gln Thr Ser Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr 
        


<210>  271
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL856 HC CDR1

<400>  271

Gly Phe Thr Phe Ser Asp Tyr Trp 
1               5               


<210>  272
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL856 HC CDR2

<400>  272

Ile Ser Ser Asp Gly Ser Thr Thr 
1               5               


<210>  273
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL856 HC CDR3

<400>  273

Ala Arg Val Ala Thr Pro Tyr Tyr Tyr Glu Ser Gly Phe Asp Tyr 
1               5                   10                  15  


<210>  274
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL856 LC CDR1

<400>  274

Asp Ile Gly Ser Lys Ser 
1               5       


<210>  275
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL856 LC CDR2

<400>  275

Asp Asp Arg 
1           


<210>  276
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL856 LC CDR3

<400>  276

Gln Val Trp Asp Ile Thr Ser Asp Leu Val Val 
1               5                   10      


<210>  277
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL856 HC

<400>  277

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Trp Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ser Arg Ile Ser Ser Asp Gly Ser Thr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Pro Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Ala Thr Pro Tyr Tyr Tyr Glu Ser Gly Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Ala Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  278
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL856 LC

<400>  278

Asp Ile Val Leu Thr Gln Ser Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Asp Ile Gly Ser Lys Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Phe 
        35                  40                  45              


Asp Asp Arg Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ile Thr Ser Asp Leu 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Val Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Val Pro Ala Glu Cys Ser 
    210                 


<210>  279
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL856 HCVR

<400>  279

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Trp Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ser Arg Ile Ser Ser Asp Gly Ser Thr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Pro Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Ala Thr Pro Tyr Tyr Tyr Glu Ser Gly Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Ala Leu Val Thr Val Ser Ser 
        115                 120         


<210>  280
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL856 LCVR

<400>  280

Asp Ile Val Leu Thr Gln Ser Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Asp Ile Gly Ser Lys Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Phe 
        35                  40                  45              


Asp Asp Arg Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ile Thr Ser Asp Leu 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Val Gly Gln 
            100                 105                 110 


<210>  281
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL858 HC CDR1

<400>  281

Gly Asp Ser Val Ile Asn Ser Ala Tyr Tyr 
1               5                   10  


<210>  282
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL858 HC CDR2

<400>  282

Val Tyr Tyr Ser Gly Ile Thr 
1               5           


<210>  283
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL858 HC CDR3

<400>  283

Ala Arg Arg Gly Gly Gly Trp Gln Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  15  


<210>  284
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL858 LC CDR1

<400>  284

Gln Ser Val Ser Thr Asn 
1               5       


<210>  285
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL858 LC CDR2

<400>  285

Gly Ala Ser 
1           


<210>  286
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL858 LC CDR3

<400>  286

Gln Gln Tyr Asp Asn Trp Leu Pro Ile Thr 
1               5                   10  


<210>  287
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL858 HC

<400>  287

Gln Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Val Ile Asn Ser 
            20                  25                  30          


Ala Tyr Tyr Trp Asp Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Val Gly Ser Val Tyr Tyr Ser Gly Ile Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Arg Leu Ser Tyr Val Thr Ala Ala Asp Thr Ala Leu Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Arg Gly Gly Gly Trp Gln Tyr Tyr Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  288
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL858 LC

<400>  288

Asp Ile Val Met Thr Gln Pro Pro Gly Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


His Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ala Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Asn Trp Leu Pro 
                85                  90                  95      


Ile Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Gln Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  289
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL858 HCVR

<400>  289

Gln Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Val Ile Asn Ser 
            20                  25                  30          


Ala Tyr Tyr Trp Asp Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Val Gly Ser Val Tyr Tyr Ser Gly Ile Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Arg Leu Ser Tyr Val Thr Ala Ala Asp Thr Ala Leu Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Arg Gly Gly Gly Trp Gln Tyr Tyr Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  290
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL858 LCVR

<400>  290

Asp Ile Val Met Thr Gln Pro Pro Gly Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


His Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ala Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Asn Trp Leu Pro 
                85                  90                  95      


Ile Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Gln Arg Thr 
            100                 105                 110 


<210>  291
<211>  584
<212>  PRT
<213>  Influenza B virus


<220>
<221>  VARIANT
<222>  (1)..(584)
<223>  B/Lee/1940 HA protein Full length

<220>
<221>  MISC_FEATURE
<222>  (486)..(486)
<223>  Xaa can be any naturally occurring amino acid

<400>  291

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Gln Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Asn Cys Phe Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Met Gly Asn Thr Pro Ser Ala Lys Val 
                85                  90                  95      


Ser Ile Leu His Glu Val Lys Pro Ala Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu Asn Ile Arg Leu Ser Thr Ser Asn Val Ile Asn Thr Glu Thr 
    130                 135                 140                 


Ala Pro Gly Gly Pro Tyr Lys Val Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Val Ala Asn Gly Asn Gly Phe Phe Asn Thr Met Ala Trp Val Ile Pro 
                165                 170                 175     


Lys Asp Asn Asn Lys Thr Ala Ile Asn Pro Val Thr Val Glu Val Pro 
            180                 185                 190         


Tyr Ile Cys Ser Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His 
        195                 200                 205             


Ser Asp Asp Lys Thr Gln Met Glu Arg Leu Tyr Gly Asp Ser Asn Pro 
    210                 215                 220                 


Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser 
225                 230                 235                 240 


Gln Ile Gly Gly Phe Pro Asn Gln Thr Glu Asp Glu Gly Leu Lys Gln 
                245                 250                 255     


Ser Gly Arg Ile Val Val Asp Tyr Met Val Gln Lys Pro Gly Lys Thr 
            260                 265                 270         


Gly Thr Ile Val Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val Trp 
        275                 280                 285             


Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile 
    290                 295                 300                 


Gly Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser 
305                 310                 315                 320 


Lys Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro 
                325                 330                 335     


Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg 
            340                 345                 350         


Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala 
        355                 360                 365             


Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly 
    370                 375                 380                 


Tyr Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys 
385                 390                 395                 400 


Ser Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Tyr Leu 
                405                 410                 415     


Ser Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asn 
            420                 425                 430         


Glu Leu His Asp Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu 
        435                 440                 445             


Arg Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser 
    450                 455                 460                 


Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu 
465                 470                 475                 480 


Arg Lys Leu Lys Lys Xaa Leu Gly Pro Ser Ala Val Glu Ile Gly Asn 
                485                 490                 495     


Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg 
            500                 505                 510         


Ile Ala Ala Gly Thr Phe Asn Ala Gly Asp Phe Ser Leu Pro Thr Phe 
        515                 520                 525             


Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp 
    530                 535                 540                 


Asn His Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu Ala 
545                 550                 555                 560 


Val Thr Leu Met Ile Ala Ile Phe Ile Val Tyr Met Val Ser Arg Asp 
                565                 570                 575     


Asn Val Ser Cys Ser Ile Cys Leu 
            580                 


<210>  292
<211>  50
<212>  PRT
<213>  Influenza B virus


<220>
<221>  VARIANT
<222>  (1)..(50)
<223>  B/Lee/1940 HA protein aa_15-65

<400>  292

Asp Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val 
1               5                   10                  15      


Lys Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu 
            20                  25                  30          


Thr Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Gln 
        35                  40                  45              


Thr Arg 
    50  


<210>  293
<211>  59
<212>  PRT
<213>  Influenza B virus


<220>
<221>  VARIANT
<222>  (1)..(59)
<223>  B/Lee/1940 HA protein aa_300-359

<400>  293

Leu Pro Leu Ile Gly Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly 
1               5                   10                  15      


Leu Asn Lys Ser Lys Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile 
            20                  25                  30          


Gly Asn Cys Pro Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly 
        35                  40                  45              


Thr Lys Tyr Arg Pro Pro Ala Lys Leu Leu Lys 
    50                  55                  


<210>  294
<211>  120
<212>  PRT
<213>  Influenza B virus


<220>
<221>  VARIANT
<222>  (1)..(120)
<223>  B/Lee/1940 HA protein aa_362-481

<400>  294

Gly Phe Phe Gly Ala Ile Ala Gly Phe Leu Glu Gly Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Ala Gly Trp His Gly Tyr Thr Ser His Gly Ala His Gly Val 
            20                  25                  30          


Ala Val Ala Ala Asp Leu Lys Ser Thr Gln Glu Ala Ile Asn Lys Ile 
        35                  40                  45              


Thr Lys Asn Leu Asn Tyr Leu Ser Glu Leu Glu Val Lys Asn Leu Gln 
    50                  55                  60                  


Arg Leu Ser Gly Ala Met Asn Glu Leu His Asp Glu Ile Leu Glu Leu 
65                  70                  75                  80  


Asp Glu Lys Val Asp Asp Leu Arg Ala Asp Thr Ile Ser Ser Gln Ile 
                85                  90                  95      


Glu Leu Ala Val Leu Leu Ser Asn Glu Gly Ile Ile Asn Ser Glu Asp 
            100                 105                 110         


Glu His Leu Leu Ala Leu Glu Arg 
        115                 120 


<210>  295
<211>  105
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (1)..(105)
<223>  Human LC Kappa constant  Kappa constant

<400>  295

Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
1               5                   10                  15      


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
            20                  25                  30          


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
        35                  40                  45              


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
    50                  55                  60                  


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
65                  70                  75                  80  


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
                85                  90                  95      


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105 


<210>  296
<211>  104
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (1)..(104)
<223>  Human LC Lambda constant Lambda constant

<400>  296

Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
1               5                   10                  15      


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
            20                  25                  30          


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
        35                  40                  45              


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
    50                  55                  60                  


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
65                  70                  75                  80  


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
                85                  90                  95      


Thr Val Val Pro Ala Glu Cys Ser 
            100                 


<210>  297
<211>  330
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (1)..(330)
<223>  Human IgG1 HC constant region Human HC constant region

<400>  297

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  298
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A/H3/HA0 consensus  N-terminal

<400>  298

Asn Val Pro Glu Lys Gln Thr Arg 
1               5               


<210>  299
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A/H3/HA0 consensus C-terminal

<400>  299

Gly Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu 
1               5                   10      


<210>  300
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A/H1/HA0 consensus N-terminal

<400>  300

Asn Ile Pro Ser Ile Gln Ser Arg 
1               5               


<210>  301
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A/H1/HA0 consensus C-terminal

<400>  301

Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu 
1               5                   10      


<210>  302
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B/HA0 consensus N-terminal

<400>  302

Pro Ala Lys Leu Leu Lys Glu Arg 
1               5               


<210>  303
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B/HA0 consensus C-terminal

<400>  303

Gly Phe Phe Gly Ala Ile Ala Gly Phe Leu Glu 
1               5                   10      


<210>  304
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5A7 Epitope 1

<400>  304

Gly Asn Cys Pro Ile Trp Val Lys 
1               5               


<210>  305
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5A7 Epitope 2

<400>  305

Leu Lys Leu Ala Asn 
1               5   


<210>  306
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5A7 Epitope 3

<400>  306

Ile Glu Leu Ala Val Leu Leu 
1               5           


<210>  307
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL845 Epitope 1

<400>  307

Ser Gln Ile Glu Leu Ala Val Leu Leu 
1               5                   


<210>  308
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL848 Epitope 1

<400>  308

Ser His Phe Ala Asn Leu Lys 
1               5           


<210>  309
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL848 Epitope 2

<400>  309

Pro Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly 
1               5                   10              


<210>  310
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL848 Epitope 3

<400>  310

Arg Leu Ser Gly 
1               


<210>  311
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL849 Epitope 1

<400>  311

Leu Asn Lys Ser Lys Pro Tyr 
1               5           


<210>  312
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL849 Epitope 2

<400>  312

Lys Leu Ala Asn Thr Gly Thr 
1               5           


<210>  313
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL849 Epitope 3

<400>  313

Met Ile Ala Gly Trp His 
1               5       


<210>  314
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRL854 Epitope 1

<400>  314

Ile Glu Leu Ala Val Leu Leu 
1               5           


