                         SEQUENCE LISTING

<110>  The Trustees of Columbia University in the City of New York
       PAJVANI, Utpal
 
<120>  GAMMA-SECRETASE INHIBITION REDUCE APOC3 LEVELS AND PLASMA 
       TRIGLYCERIDES

<130>  0575/86108-A-PCT/JPW/GJG

<150>  62/032,324
<151>  2014-08-01

<150>  61/936,279
<151>  2014-02-05

<160>  58    

<170>  PatentIn version 3.5

<210>  1
<211>  709
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Thr Ala Gly Gly Gly Ser Gly Ala Asp Pro Gly Ser Arg Gly 
1               5                   10                  15      


Leu Leu Arg Leu Leu Ser Phe Cys Val Leu Leu Ala Gly Leu Cys Arg 
            20                  25                  30          


Gly Asn Ser Val Glu Arg Lys Ile Tyr Ile Pro Leu Asn Lys Thr Ala 
        35                  40                  45              


Pro Cys Val Arg Leu Leu Asn Ala Thr His Gln Ile Gly Cys Gln Ser 
    50                  55                  60                  


Ser Ile Ser Gly Asp Thr Gly Val Ile His Val Val Glu Lys Glu Glu 
65                  70                  75                  80  


Asp Leu Gln Trp Val Leu Thr Asp Gly Pro Asn Pro Pro Tyr Met Val 
                85                  90                  95      


Leu Leu Glu Ser Lys His Phe Thr Arg Asp Leu Met Glu Lys Leu Lys 
            100                 105                 110         


Gly Arg Thr Ser Arg Ile Ala Gly Leu Ala Val Ser Leu Thr Lys Pro 
        115                 120                 125             


Ser Pro Ala Ser Gly Phe Ser Pro Ser Val Gln Cys Pro Asn Asp Gly 
    130                 135                 140                 


Phe Gly Val Tyr Ser Asn Ser Tyr Gly Pro Glu Phe Ala His Cys Arg 
145                 150                 155                 160 


Glu Ile Gln Trp Asn Ser Leu Gly Asn Gly Leu Ala Tyr Glu Asp Phe 
                165                 170                 175     


Ser Phe Pro Ile Phe Leu Leu Glu Asp Glu Asn Glu Thr Lys Val Ile 
            180                 185                 190         


Lys Gln Cys Tyr Gln Asp His Asn Leu Ser Gln Asn Gly Ser Ala Pro 
        195                 200                 205             


Thr Phe Pro Leu Cys Ala Met Gln Leu Phe Ser His Met His Ala Val 
    210                 215                 220                 


Ile Ser Thr Ala Thr Cys Met Arg Arg Ser Ser Ile Gln Ser Thr Phe 
225                 230                 235                 240 


Ser Ile Asn Pro Glu Ile Val Cys Asp Pro Leu Ser Asp Tyr Asn Val 
                245                 250                 255     


Trp Ser Met Leu Lys Pro Ile Asn Thr Thr Gly Thr Leu Lys Pro Asp 
            260                 265                 270         


Asp Arg Val Val Val Ala Ala Thr Arg Leu Asp Ser Arg Ser Phe Phe 
        275                 280                 285             


Trp Asn Val Ala Pro Gly Ala Glu Ser Ala Val Ala Ser Phe Val Thr 
    290                 295                 300                 


Gln Leu Ala Ala Ala Glu Ala Leu Gln Lys Ala Pro Asp Val Thr Thr 
305                 310                 315                 320 


Leu Pro Arg Asn Val Met Phe Val Phe Phe Gln Gly Glu Thr Phe Asp 
                325                 330                 335     


Tyr Ile Gly Ser Ser Arg Met Val Tyr Asp Met Glu Lys Gly Lys Phe 
            340                 345                 350         


Pro Val Gln Leu Glu Asn Val Asp Ser Phe Val Glu Leu Gly Gln Val 
        355                 360                 365             


Ala Leu Arg Thr Ser Leu Glu Leu Trp Met His Thr Asp Pro Val Ser 
    370                 375                 380                 


Gln Lys Asn Glu Ser Val Arg Asn Gln Val Glu Asp Leu Leu Ala Thr 
385                 390                 395                 400 


Leu Glu Lys Ser Gly Ala Gly Val Pro Ala Val Ile Leu Arg Arg Pro 
                405                 410                 415     


Asn Gln Ser Gln Pro Leu Pro Pro Ser Ser Leu Gln Arg Phe Leu Arg 
            420                 425                 430         


Ala Arg Asn Ile Ser Gly Val Val Leu Ala Asp His Ser Gly Ala Phe 
        435                 440                 445             


His Asn Lys Tyr Tyr Gln Ser Ile Tyr Asp Thr Ala Glu Asn Ile Asn 
    450                 455                 460                 


Val Ser Tyr Pro Glu Trp Leu Ser Pro Glu Glu Asp Leu Asn Phe Val 
465                 470                 475                 480 


Thr Asp Thr Ala Lys Ala Leu Ala Asp Val Ala Thr Val Leu Gly Arg 
                485                 490                 495     


Ala Leu Tyr Glu Leu Ala Gly Gly Thr Asn Phe Ser Asp Thr Val Gln 
            500                 505                 510         


Ala Asp Pro Gln Thr Val Thr Arg Leu Leu Tyr Gly Phe Leu Ile Lys 
        515                 520                 525             


Ala Asn Asn Ser Trp Phe Gln Ser Ile Leu Arg Gln Asp Leu Arg Ser 
    530                 535                 540                 


Tyr Leu Gly Asp Gly Pro Leu Gln His Tyr Ile Ala Val Ser Ser Pro 
545                 550                 555                 560 


Thr Asn Thr Thr Tyr Val Val Gln Tyr Ala Leu Ala Asn Leu Thr Gly 
                565                 570                 575     


Thr Val Val Asn Leu Thr Arg Glu Gln Cys Gln Asp Pro Ser Lys Val 
            580                 585                 590         


Pro Ser Glu Asn Lys Asp Leu Tyr Glu Tyr Ser Trp Val Gln Gly Pro 
        595                 600                 605             


Leu His Ser Asn Glu Thr Asp Arg Leu Pro Arg Cys Val Arg Ser Thr 
    610                 615                 620                 


Ala Arg Leu Ala Arg Ala Leu Ser Pro Ala Phe Glu Leu Ser Gln Trp 
625                 630                 635                 640 


Ser Ser Thr Glu Tyr Ser Thr Trp Thr Glu Ser Arg Trp Lys Asp Ile 
                645                 650                 655     


Arg Ala Arg Ile Phe Leu Ile Ala Ser Lys Glu Leu Glu Leu Ile Thr 
            660                 665                 670         


Leu Thr Val Gly Phe Gly Ile Leu Ile Phe Ser Leu Ile Val Thr Tyr 
        675                 680                 685             


Cys Ile Asn Ala Lys Ala Asp Val Leu Phe Ile Ala Pro Arg Glu Pro 
    690                 695                 700                 


Gly Ala Val Ser Tyr 
705                 


<210>  2
<211>  2949
<212>  DNA
<213>  Homo sapiens

<400>  2
tctgcagaat tcggcttgcg cctggaaaca cgaacttccg gtctcttagg ctccgggcca       60

cagagacggt gtcagtggta gcctagagag gccgctaaca gacaggagcc gaacgggggc      120

ttccgctcag cagagaggca agatggctac ggcagggggt ggctctgggg ctgacccggg      180

aagtcggggt ctccttcgcc ttctgtcttt ctgcgtccta ctagcaggtt tgtgcagggg      240

aaactcagtg gagaggaaga tatatatccc cttaaataaa acagctccct gtgttcgcct      300

gctcaacgcc actcatcaga ttggctgcca gtcttcaatt agtggagaca caggggttat      360

ccacgtagta gagaaagagg aggacctaca gtgggtattg actgatggcc ccaacccccc      420

ttacatggtt ctgctggaga gcaagcattt taccagggat ttaatggaga agctgaaagg      480

gagaaccagc cgaattgctg gtcttgcagt gtccttgacc aagcccagtc ctgcctcagg      540

cttctctcct agtgtacagt gcccaaatga tgggtttggt gtttactcca attcctatgg      600

gccagagttt gctcactgca gagaaataca gtggaattcg ctgggcaatg gtttggctta      660

tgaagacttt agtttcccca tctttcttct tgaagatgaa aatgaaacca aagtcatcaa      720

gcagtgctat caagatcaca acctgagtca gaatggctca gcaccaacct tcccactatg      780

tgccatgcag ctcttttcac acatgcatgc tgtcatcagc actgccacct gcatgcggcg      840

cagctccatc caaagcacct tcagcatcaa cccagaaatc gtctgtgacc ccctgtctga      900

ttacaatgtg tggagcatgc taaagcctat aaatacaact gggacattaa agcctgacga      960

cagggttgtg gttgctgcca cccggctgga tagtcgttcc tttttctgga atgtggcccc     1020

aggggctgaa agcgcagtgg cttcctttgt cacccagctg gctgctgctg aagctttgca     1080

aaaggcacct gatgtgacca ccctgccccg caatgtcatg tttgtcttct ttcaagggga     1140

aacttttgac tacattggca gctcgaggat ggtctacgat atggagaagg gcaagtttcc     1200

cgtgcagtta gagaatgttg actcatttgt ggagctggga caggtggcct taagaacttc     1260

attagagctt tggatgcaca cagatcctgt ttctcagaaa aatgagtctg tacggaacca     1320

ggtggaggat ctcctggcca cattggagaa gagtggtgct ggtgtccctg ctgtcatcct     1380

caggaggcca aatcagtccc agcctctccc accatcttcc ctgcagcgat ttcttcgagc     1440

tcgaaacatc tctggcgttg ttctggctga ccactctggt gccttccata acaaatatta     1500

ccagagtatt tacgacactg ctgagaacat taatgtgagc tatcccgaat ggctgagccc     1560

tgaagaggac ctgaactttg taacagacac tgccaaggcc ctggcagatg tggccacggt     1620

gctgggacgt gctctgtatg agcttgcagg aggaaccaac ttcagcgaca cagttcaggc     1680

tgatccccaa acggttaccc gcctgctcta tgggttcctg attaaagcca acaactcatg     1740

gttccagtct atcctcaggc aggacctaag gtcctacttg ggtgacgggc ctcttcaaca     1800

ttacatcgct gtctccagcc ccaccaacac cacttatgtt gtacagtatg ccttggcaaa     1860

tttgactggc acagtggtca acctcacccg agagcagtgc caggatccaa gtaaagtccc     1920

aagtgaaaac aaggatctgt atgagtactc atgggtccag ggccctttgc attctaatga     1980

gacggaccga ctcccccggt gtgtgcgttc tactgcacga ttagccaggg ccttgtctcc     2040

tgcctttgaa ctgagtcagt ggagctctac tgaatactct acatggactg agagccgctg     2100

gaaagatatc cgtgcccgga tatttctcat cgccagcaaa gagcttgagt tgatcaccct     2160

gacagtgggc ttcggcatcc tcatcttctc cctcatcgtc acctactgca tcaatgccaa     2220

agctgatgtc cttttcattg ctccccggga gccaggagct gtgtcatact gagsaggacc     2280

scagcttttc ttgccagctc agcagttcac ttcctagagc atctgtccca ctgggacaca     2340

accactaatt tgtcactgga acctccctgg gcctgtctca gattgggatt aacataaaag     2400

agtggaacta tccaaaagag acagggagaa ataaataaat tgcctccctt cctccgctcc     2460

cctttcccat caccccttcc ccatttcctc ttccttctct actcatgcca gattttggga     2520

ttacaaatag aagcttcttg ctcctgttta actccctagt tacccaccct aatttgccct     2580

tcaggaccct tctacttttt ccttcctgcc ctgtacctct ctctgctcct cacccccacc     2640

cctgtaccca gccaccttcc tgactgggaa ggacataaaa ggtttaatgt cagggtcaaa     2700

ctacattgag cccctgagga caggggcatc tctgggctga gcctactgtc tccttcccac     2760

tgtcctttct ccaggccctc agatggcaca ttagggtggg cgtgctgcgg gtgggtatcc     2820

cacctccagc ccacagtgct cagttgtact ttttattaag ctgtaatatc tatttttgtt     2880

tttgtctttt tcctttattc tttttgtaaa tatatatata atgagtttca ttaaaataga     2940

ttatcccac                                                             2949


<210>  3
<211>  1912
<212>  DNA
<213>  Homo sapiens

<400>  3
ttactccaat tcctatgggc cagagtttgc tcactgcaga gaaatacagt ggaattcgct       60

gggcaatggt ttggcttatg aagactttag tttccccatc tttcttcttg aagatgaaaa      120

tgaaaccaaa gtcatcaagc agaaatcgtc tgtgaccccc tgtctgatta caatgtgtgg      180

agcatgctaa agcctataaa tacaactggg acattaaagc ctgacgacag ggttgtggtt      240

gctgccaccc ggctggatag tcgttccttt ttctggaatg tggccccagg ggctgaaagc      300

gcagtggctt cctttgtcac ccagctggct gctgctgaag ctttgcaaaa ggcacctgat      360

gtgaccaccc tgccccgcaa tgtcatgttt gtcttctttc aaggggaaac ttttgactac      420

attggcagct cgaggatggt ctacgatatg gagaagggca agtttcccgt gcagttagag      480

aatgttgact catttgtgga gctgggacag gtggccttaa gaacttcatt agagctttgg      540

atgcacacag atcctgtttc tcagaaaaat gagtctgtac ggaaccaggt ggaggatctc      600

ctggccacat tggagaagag tggtgctggt gtccctgctg tcatcctcag gaggccaaat      660

cagtcccagc ctctcccacc atcttccctg cagcgatttc ttcgagctcg aaacatctct      720

ggcgttgttc tggctgacca ctctggtgcc ttccataaca aatattacca gagtatttac      780

gacactgctg agaacattaa tgtgagctat cccgaatggc tgagccctga agaggacctg      840

aactttgtaa cagacactgc caaggccctg gcagatgtgg ccacggtgct gggacgtgct      900

ctgtatgagc ttgcaggagg aaccaacttc agcgacacag ttcaggctga tccccaaacg      960

gttacccgcc tgctctatgg gttcctgatt aaagccaaca actcatggtt ccagtctatc     1020

ctcaggcagg acctaaggtc ctacttgggt gacgggcctc ttcaacatta catcgctgtc     1080

tccagcccca ccaacaccac ttatgttgta cagtatgcct tggcaaattt gactggcaca     1140

gtggtcaacc tcacccgaga gcagtgccag gatccaagta aagtcccaag tgaaaacaag     1200

gatctgtatg agtactcatg ggtccagggc cctttgcatt ctaatgagac ggaccgactc     1260

ccccggtgtg tgcgttctac tgcacgatta gccagggcct tgtctcctgc ctttgaactg     1320

agtcagtgga gctctactga atactctaca tggactgaga gccgctggaa agatatccgt     1380

gcccggatat ttctcatcgc cagcaaagag cttgagttga tcaccctgac agtgggcttc     1440

ggcatcctca tcttctccct catcgtcacc tactgcatca atgccaaagc tgatgtcctt     1500

ttcattgttc cccgggagcc aggagctgtg tcatactgag gaggacccca gcttttcttg     1560

ccagctcagc agttcacttc ctagagcatc tgtcccactg ggacacaacc actaatttgt     1620

cactggaacc tccctgggcc tgtctcagat tgggattaac ataaaagagt ggaactatcc     1680

aaaagagaca gggagaaata aataaattgc ctcccttcct ccgctcccct ttcccatcac     1740

cccttcccca tttcctcttc cttctctact catgccagat tttgggatta caaatagaag     1800

cttcttgctc ctgtttaact ccctagttac ccaccctaat ttgcccttca ggacccttct     1860

actttttcct tcctgccctg tacctctctc tgctcctcac ccccacccct gt             1912


<210>  4
<211>  1979
<212>  DNA
<213>  Homo sapiens

<400>  4
agagaggcaa gatggctacg gcagggggtg gctctggggc tgacccggga agtcggggtc       60

tccttcgcct tctgtctttc tgcgtcctac tagcaggttt gtgcagggga aactcagtgg      120

agaggaagat atatatcccc ttaaataaaa cagctccctg tgttcgcctg ctcaacgcca      180

ctcatcagat tggctgccag tcttcaatta gtggagacac aggggttatc cacgtagtag      240

agaaagagga ggacctacag tgggtattga ctgatggccc caacccccct tacatggttc      300

tgctggagag caagcatttt accagggatt taatggagaa gctgaaaggg agaaccagcc      360

gaattgctgg tcttgcagtg tccttgacca agcccagtcc tgcctcaggc ttctctccta      420

gtgtacagtg cccaaatgat gggtttggtg tttactccaa ttcctatggg ccagagtttg      480

ctcactgcag agaaatacag tggaattcgc tgggcaatgg tttggcttat gaagacttta      540

gtttccccat ctttcttctt gaagatgaaa atgaaaccaa agtcatcaag caggaaactt      600

ttgactacat tggcagctcg aggatggtct acgatatgga gaagggcaag tttcccgtgc      660

agttagagaa tgttgactca tttgtggagc tgggacaggt ggccttaaga acttcattag      720

agcttttgat gcacacagat cctgtttctc agaaaaatga gtctgtacgg aaccaggtgg      780

aggatctcct ggccacattg gagaagagtg gtgctggtgt ccctgctgtc atcctcagga      840

ggccaaatca gtcccagcct ctcccaccat cttccctgca gcgatttctt cgagctcgaa      900

acatctctgg cgttgttctg gctgaccacc ctggtgcctt ccataacaaa tattaccaga      960

gtatttacga cactgctgag aacattaatg tgagctatcc cgaatggctg agccctgaag     1020

aggacctgaa ctttgtaaca gacactgcca aggccctggc agatgtggcc acggtgctgg     1080

gacgtgctct gtatgagctt gcaggaggaa ccaacttcag cgacacagtt caggctgatc     1140

cccaaacggt tacccgcctg ctctatgggt tcctgattaa agccaacaac tcatggttcc     1200

agtctatcct caggcaggac ctaaggtcct acttgggtga cgggcctctt caacattaca     1260

tcgctgtctc cagccccacc aacaccactt atgttgtaca gtatgccttg gcaaatttga     1320

ctggcacagt ggtcaacctc acccgagagc agtgccagga tccaagtaaa gtcccaagtg     1380

aaaacaagga tctgtatgag tactcatggg tccagggccc tttgcattct aatgagacgg     1440

accgactccc ccggtgtgtg cgttctactg cacgattagc cagggccttg tctcctgcct     1500

ttgaactgag ccagtggagc tctactgaat actctacatg gactgagagc cgctggaaag     1560

atatccgtgc ccggatattt ctcatcgcca gcaaagagct tgagttgatc accctgacag     1620

tgggcttcgg catcctcatc ttctccctca tcgtcaccta ctgcatcaat gccaaagctg     1680

atgtcctttt cattgctccc cgggagccag gagctgtgtc atactgagga ggaccccagc     1740

ttttcttgcc agctcagcag ttcacttcct agagcatctg tcccactggg acacaaccac     1800

taatttgtca ctggaacctc cctgggcctg tctcagattg ggattaacat aaaagagtgg     1860

aactatccaa aagagacagg gagaaataaa taaattgcct cccttcctcc gctccccttt     1920

cccatcaccc cttccccatt tcctcttcct tctctactca tgccagattt tgggattac      1979


<210>  5
<211>  580
<212>  DNA
<213>  Homo sapiens

<400>  5
cgctcagcag agaggcaaga tggctacggc agggggtggc tctggggctg acccgggaag       60

tcggggtctc cttcgccttc tgtctttctg cgtcctacta gcaggcctct tcctggactt      120

cgagcctgac cctctcccac tttgtccaga tgtctcgttt ttcccacaac cccagccacc      180

caccccacag tcgaaaggaa caggtgtgaa agttagcttt cttcctcgcg tttagacttt      240

ttgagacgaa agcaatcttg ttctgtgggt gctgtgcggc gcttaaaagg tttgtgcagg      300

ggaaactcag tggagaggaa gatatatatc cccttaaata aaacagctcc ctgtgttcgc      360

ctgctcaacg ccactcatca gattggctgc cagtcttcaa ttagtggaga cacaggggtt      420

atccacgtag tagagaaaga ggaggaccta cagtgggtat tgactgatgg ccccaacccc      480

ccttacatgg ttctgctgga gagcaagcat tttaccaggg atttaatgga gaagctgaaa      540

gggagaacca gccgaattgc tggtcttgca gtgtccttga                            580


<210>  6
<211>  2161
<212>  DNA
<213>  Homo sapiens

<400>  6
aacgggggct tccgctcagc agagaggcaa gatggctacg gcagggggtg gctctggggc       60

tgacccggga agtcggggtc tccttcgcct tctgtctttc tgcgtcctac tagcaggttt      120

gtgcagggga aactcagtgg agaggaagat atatatcccc ttaaataaaa cagctccctg      180

tgttcgcctg ctcaacgcca ctcatcagat tggctgccag tcttcaatta gtggagacac      240

aggggttatc cacgtagtag agaaagagga ggacctacag tgggtattga ctgatggccc      300

caacccccct tacatggttc tgctggagag caagcatttt accagggatt taatggagaa      360

gctgaaaggg agaaccagcc gaattgctgg tcttgcagtg tccttgacca agcccagtcc      420

tgcctcaggc ttctctccta gtgtacagtg cccaaatgat gggtttggtg tttactccaa      480

ttcctatggg ccagagtttg ctcactgcag agaaatacag tggaattcgc tgggcaatgg      540

tttggcttat gaagacttta gtttccccat ctttcttctt gaagatgaaa atgaaaccaa      600

agtcatcaag cagtgctatc aagatcacaa cctgagtcag aatggctcag caccaacctt      660

cccactatgc gccatgcagc tcttttcaca catgcatgct gtcatcagca ctgccacctg      720

catgcggcgc agctccatcc aaagcacctt cagcatcaac ccagaaatcg tctgtgaccc      780

cctgtctgat tacaatgtgt ggagcatgct aaagcctata aatacaactg ggacattaaa      840

gcctgacgac agggttgtgg ttgctgccac ccggctggat agtcgttcct ttttctggaa      900

tgtggcccca ggggctgaaa gcgcagtggc ttcctttgtc acccagctgg ctgctgctga      960

agctttgcaa aaggcacctg atgtgaccac cctgccccgc aatgtcatgt ttgtcttctt     1020

tcaaggggaa acttttgact acattggcag ctcgaggatg gtctacgata tggagaaggg     1080

caagtttccc gtgcagttag agaatgttga ctcatttgtg gagctgggac aggtggcctt     1140

aagaacttca ttagagcttt ggatgcacac agatcctgtt tctcagaaaa atgagtctgt     1200

acggaaccag gtggaggatc tcctggccac attggagaag agtggtgctg gtgtccctgc     1260

tgtcatcctc aggaggccaa atcagtccca gcctctccca ccatcttccc tgcagcgatt     1320

tcttcgagct cgaaacatct ctggcgttgt tctggctgac cactctggtg ccttccataa     1380

caaatattac cagagtattt acgacactgc tgagaacatt aatgtgagct atcccgaatg     1440

gctgagccct gaagaggacc tgaactttgt aacagacact gccaaggccc tggcagatgt     1500

ggccacggtg ctgggacgtg ctctgtatga gcttgcagga ggaaccaact tcagcgacac     1560

agttcaggct gatccccaaa cggttacccg cctgctctat gggttcctga ttaaagccaa     1620

caactcatgg ttccagtcta tcctcaggca ggacctaagg tcctacttgg gtgacgggcc     1680

tcttcaacat tacatcgctg tctccagccc caccaacacc acttatgttg tacagtatgc     1740

cttggcgaat ttgactggca cagtggtcaa cctcacccga gagcagtgcc aggatccaag     1800

taaagtccca agtgaaaaca aggatctgta tgagtactca tgggtccagg gccctttgca     1860

ttctaatgag acggaccgac tcccccggtg tgtgcgttct actgcacgat tagccagggc     1920

cttgtctcct gcctttgaac tgagtcagtg gagctctact gaatactcta catggactga     1980

gagccgctgg aaagatatcc gtgcccggat atttctcatc gccagcaaag agcttgagtt     2040

gatcaccctg acagtgggct tcggcatcct catcttctcc ctcatcgtca cctactgcat     2100

caatgccaaa gctgatgtcc ttttcattgc tccccgggag ccaggagctg tgtcatactg     2160

a                                                                     2161


<210>  7
<211>  2806
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (2157)..(2157)
<223>  n is a, c, g, or t

<400>  7
gatggctacg gcagggggtg gctctggggc tgacccggga agtcggggtc tccttcgcct       60

tctgtctttc tgcgtcctac tagcaggttt gtgcagggga aactcagtgg agaggaagat      120

atatatcccc ttaaataaaa cagctccctg tgttcgcctg ctcaacgcca ctcatcagat      180

tggctgccag tcttcaatta gtggagacac aggggttatc cacgtagtag agaaagagga      240

ggacctacag tgggtattga ctgatggccc caacccccct tacatggttc tgctggagag      300

caagcatttt accagggatt taatggagaa gctgaaaggg agaaccagcc gaattgctgg      360

tcttgcagtg tccttgacca agcccagtcc tgcctcaggc ttctctccta gtgtacagtg      420

cccaaatgat gggtttggtg tttactccaa ttcctatggg ccagagtttg ctcactgcag      480

agaaatacag tggaattcgc tgggcaatgg tttggcttat gaagacttta gtttccccat      540

ctttcttctt gaagatgaaa atgaaaccaa agtcatcaag cagtgctatc aagatcacaa      600

cctgagtcag aatggctcag caccaacctt cccactatgt gccatgcagc tcttttcaca      660

catgcatgct gtcatcagca ctgccacctg catgcggcgc agctccatcc aaagcacctt      720

cagcatcaac ccagaaatcg tctgtgaccc cctgtctgat tacaatgtgt ggagcatgct      780

aaagcctata aatacaactg ggacattaaa gcctgacgac agggttgtgg ttgctgccac      840

ccggctggat agtcgttcct ttttctggaa tgtggcccca ggggctgaaa gcgcagtggc      900

ttcctttgtc acccagctgg ctgctgctga agctttgcaa aaggcacctg atgtgaccac      960

cctgccccgc aatgtcatgt ttgtcttctt tcaaggggaa acttttgact acattggcag     1020

ctcgaggatg gtctacgata tggagaaggg caagtttccc gtgcagttag agaatgttga     1080

ctcatttgtg gagctgggac aggtggcctt aagaacttca ttagagcttt ggatgcacac     1140

agatcctgtt tctcagaaaa atgagtctgt acggaaccag gtggaggatc tcctggccac     1200

attggagaag agtggtgctg gtgtccctgc tgtcatcctc aggaggccaa atcagtccca     1260

gcctctccca ccatcttccc tgcagcgatt tcttcgagct cgaaacatct ctggcgttgt     1320

tctggctgac cactctggtg ccttccataa caaatattac cagagtattt acgacactgc     1380

tgagaacatt aatgtgagct atcccgaatg gctgagccct gaagaggacc tgaactttgt     1440

aacagacact gccaaggccc tggcagatgt ggccacggtg ctgggacgtg ctctgtatga     1500

gcttgcagga ggaaccaact tcagcgacac agttcaggct gatccccaaa cggttacccg     1560

cctgctctat gggttcctga ttaaagccaa caactcatgg ttccagtcta tcctcaggca     1620

ggacctaagg tcctacttgg gtgacgggcc tcttcaacat tacatcgctg tctccagccc     1680

caccaacacc acttatgttg tacagtatgc cttggcaaat ttgactggca cagtggtcaa     1740

cctcacccga gagcagtgcc aggatccaag taaagtccca agtgaaaaca aggatctgta     1800

tgagtactca tgggtccagg gccctttgca ttctaatgag acggaccgac tcccccggtg     1860

tgtgcgttct actgcacgat tagccagggc cttgtctcct gcctttgaac tgagtcagtg     1920

gagctctact gaatactcta catggactga gagccgctgg aaagatatcc gtgcccggat     1980

atttctcatc gccagcaaag agcttgagtt gatcaccctg acagtgggct tcggcatcct     2040

catcttctcc ctcatcgtca cctactgcat caatgccaaa gctgatgtcc ttttcattgc     2100

tccccgggag ccaggagctg tgtcatactg aggaggaccc cagcttttct tgccagntca     2160

gcagttcact tcctagagca tctgtcccac tgggacacaa ccactaattt gtcactggaa     2220

cctccctggg cctgtctcag attgggatta acataaaaga gtggaactat ccaaaagaga     2280

cagggagaaa taaataaatt gcctcccttc ctccgctccc ctttcccatc accccttccc     2340

catttcctct tccttctcta ctcatgccag attttgggat tacaaataga agcttcttgc     2400

tcctgtttaa ctccctagtt acccacccta atttgccctt caggaccctt ctactttttc     2460

cttcctgccc tgtacctctc tctgctcctc acccccaccc ctgtacccag ccaccttcct     2520

gactgggaag gacataaaag gtttaatgtc agggtcaaac tacattgagc ccctgaggac     2580

aggggcatct ctgggctgag cctactgtct ccttcccact gtcctttctc caggccctca     2640

gatggcacat tagggtgggc gtgctgcggg tgggtatccc acctccagcc cacagtgctc     2700

agttgtactt tttattaagc tgtaatatct atttttgttt ttgtcttttt cctttattct     2760

ttttgtaaat atatatataa tgagtttcat taaaatagat tatccc                    2806


<210>  8
<211>  3041
<212>  DNA
<213>  Homo sapiens

<400>  8
agagacggtg tcagtggtag cctagagagg ccgctaacag acaggagccg aacgggggct       60

tccgctcagc agagaggcaa gatggctacg gcagggggtg gctctggggc tgacccggga      120

agtcggggtc tccttcgcct tctgtctttc tgcgtcctac tagcagtgtc actgtcaatg      180

gcgctacatg gactttgtaa taaccctttg aggcacatag ctgggtgcca tgtagaacat      240

gtatctgtta cgataagtgt gtgcccaaga aatcagaaga atggacttta atctcatttt      300

agaaagtttg tgcaggggaa actcagtgga gaggaagata tatatcccct taaataaaac      360

agctccctgt gttcgcctgc tcaacgccac tcatcagatt ggctgccagt cttcaattag      420

tggagacaca ggggttatcc acgtagtaga gaaagaggag gacctacagt gggtattgac      480

tgatggcccc aacccccctt acatggttct gctggagagc aagcatttta ccagggattt      540

aatggagaag ctgaaaggga gaaccagccg aattgctggt cttgcagtgt ccttgaccaa      600

gcccagtcct gcctcaggct tctctcctag tgtacagtgc ccaaatgatg ggtttggtgt      660

ttactccaat tcctatgggc cagagtttgc tcactgcaga gaaatacagt ggaattcgct      720

gggcaatggt ttggcttatg aagactttag tttccccatc tttcttcttg aagatgaaaa      780

tgaaaccaaa gtcatcaagc agtgctatca agatcacaac ctgagtcaga atggctcagc      840

accaaccttc ccactatgtg ccatgcagct cttttcacac atgcatgctg tcatcagcac      900

tgccacctgc atgcggcgca gctccatcca aagcaccttc agcatcaacc cagaaatcgt      960

ctgtgacccc ctgtctgatt acaatgtgtg gagcatgcta aagcctataa atacaactgg     1020

gacattaaag cctgacgaca gggttgtggt tgctgccacc cggctggata gtcgttcctt     1080

tttctggaat gtggccccag gggctgaaag cgcagtggct tcctttgtca cccagctggc     1140

tgctgctgaa gctttgcaaa aggcacctga tgtgaccacc ctgccccgca atgtcatgtt     1200

tgtcttcttt caaggggaaa cttttgacta cattggcagc tcgaggatgg tctacgatat     1260

ggagaagggc aagtttcccg tgcagttaga gaatgttgac tcatttgtgg agctgggaca     1320

ggtggcctta agaacttcat tagagctttg gatgcacaca gatcctgttt ctcagaaaaa     1380

tgagtctgta cggaaccagg tggaggatct cctggccaca ttggagaaga gtggtgctgg     1440

tgtccctgct gtcatcctca ggaggccaaa tcagtcccag cctctcccac catcttccct     1500

gcagcgattt cttcgagctc gaaacatctc tggcgttgtt ctggctgacc actctggtgc     1560

cttccataac aaatattacc agagtattta cgacactgct gagaacatta atgtgagcta     1620

tcccgaatgg ctgagccctg aagaggacct gaactttgta acagacactg ccaaggccct     1680

ggcagatgtg gccacggtgc tgggacgtgc tctgtatgag cttgcaggag gaaccaactt     1740

cagcgacaca gttcaggctg atccccaaac ggttacccgc ctgctctatg ggttcctgat     1800

taaagccaac aactcatggt tccagtctat cctcaggcag gacctaaggt cctacttggg     1860

tgacgggcct cttcaacatt acatcgctgt ctccagcccc accaacacca cttatgttgt     1920

acagtatgcc ttggcaaatt tgactggcac agtggtcaac ctcacccgag agcagtgcca     1980

ggatccaagt aaagtcccaa gtgaaaacaa ggatctgtat gagtactcat gggtccaggg     2040

ccctttgcat tctaatgaga cggaccgact cccccggtgt gtgcgttcta ctgcacgatt     2100

agccagggcc ttgtctcctg cctttgaact gagtcagtgg agctctactg aatactctac     2160

atggactgag agccgctgga aagatatcca tgcccggata tttctcatcg ccagcaaaga     2220

gcttgagttg atcaccctga cagtgggctt cggcatcctc atcttctccc tcatcgtcac     2280

ctactgcatc aatgccaaag ctgatgtcct tttcattgct ccccgggagc caggagctgt     2340

gtcatactga ggaggacccc agcttttctt gccagctcag cagttcactt cctagagcat     2400

ctgtcccact gggacacaac cactaatttg tcactggaac ctccctgggc ctgtctcaga     2460

ttgggattaa cataaaagag tggaactatc caaaagagac agggagaaat aaataaattg     2520

cctcccttcc tccgctcccc tttcccatca ccccttcccc atttcctctt ccttctctac     2580

tcatgccaga ttttgggatt acaaatagaa gcttcttgct cctgtttaac tccctagtta     2640

cccaccctaa tttgcccttc aggacccttc tactttttcc ttcctgccct gtacctctct     2700

ctgctcctca cccccacccc tgtacccagc caccttcctg actgggaagg acataaaagg     2760

tttaatgtca gggtcaaact acattgagcc cctgaggaca ggggcatctc tgggctgagc     2820

ctactgtctc cttcccactg tcctttctcc aggccctcag atggcacatt agggtgggcg     2880

tgctgcgggt gggtatccca cctccagccc acagtgctca gttgtacttt ttattaagct     2940

gtaatatcta tttttgtttt tgtctttttc ctttattctt tttgtaaata tatatataat     3000

gagtttcatt aaaatagatt atcccaaaaa aaaaaaaaaa a                         3041


<210>  9
<211>  2821
<212>  DNA
<213>  Homo sapiens

<400>  9
tggctacggc agggggtggc tctggggctg acccgggaag tcggggtctc cttcgccttc       60

tgtctttctg cgtcctacta gcaggtttgt gcaggggaaa ctcagtggag aggaagatat      120

atatcccctt aaataaaaca gctccctgtg ttcgcctgct caacgccact catcagattg      180

gctgccagtc ttcaattagt ggagacacag gggttatcca cgtagtagag aaagaggagg      240

acctacagtg ggtattgact gatggcccca acccccctta catggttctg ctggagagca      300

agcattttac cagggattta atggagaagc tgaaagggag aaccagccga attgctggtc      360

ttgcagtgtc cttgaccaag cccagtcctg cctcaggctt ctctcctagt gtacagtgcc      420

caaatgatgg gtttggtgtt tactccaatt cctatgggcc agagtttgct cactgcagag      480

aaatacagtg gaattcgctg ggcaatggtt tggcttatga agactttagt ttccccatct      540

ttcttcttga agatgaaaat gaaaccaaag tcatcaagca gtgctatcaa gatcacaacc      600

tgagtcagaa tggctcagca ccaaccttcc cactatgtgc catgcagctc ttttcacaca      660

tgcatgctgt catcagcact gccacctgca tgcggcgcag ctccatccaa agcaccttca      720

gcatcaaccc agaaatcgtc tgtgaccccc tgtctgatta caatgtgtgg agcatgctaa      780

agcctataaa tacaactggg acattaaagc ctgacgacag ggttgtggtt gctgccaccc      840

ggctggatag tcgttccttt ttctggaatg tggccccagg ggctgaaagc gcagtggctt      900

cctttgtcac ccagctggct gctgctgaag ctttgcaaaa ggcacctgat gtgaccaccc      960

tgccccgcaa tgtcatgttt gtcttctttc aaggggaaac ttttgactac attggcagct     1020

cgaggatggt ctacgatgga gaagggcaag tttcccgtgc agttagagaa tgttgactca     1080

tttgtggagc tgggacaggt ggccttaaga acttcattag agctttggat gcacacagat     1140

cctgtttctc agaaaaatga gtctgtacgg aaccaggtgg aggatctcct ggccacattg     1200

gagaagagtg gtgctggtgt ccctgctgtc atcctcagga ggccaaatca gtcccagcct     1260

ctcccaccat cttccctgca gcgatttctt cgagctcgaa acatctctgg cgttgttctg     1320

gctgaccact ctggtgcctt ccataacaaa tattaccaga gtatttacga cactgctgag     1380

aacattaatg tgagctatcc cgaatggctg agccctgaag aggacctgaa ctttgtaaca     1440

gacactgcca aggccctggc agatgtggcc acggtgctgg gacgtgctct gtatgagctt     1500

gcaggaggaa ccaacttcag cgacacagtt caggctgatc cccaaacggt tacccgcctg     1560

ctctatgggt tcctgattaa agccaacaac tcatggttcc agtctatcct caggcaggac     1620

ctaaggtcct acttgggtga cgggcctctt caacattaca tcgctgtctc cagccccacc     1680

aacaccactt atgttgtaca gtatgccttg gcaaatttga ctggcacagt ggtcaacctc     1740

acccgagagc agtgccagga tccaagtaaa gtcccaagtg aaaacaagga tctgtatgag     1800

tactcatggg tccagggccc tttgcattct aatgagacgg accgactccc ccggtgtgtg     1860

cgttctactg cacgattagc cagggccttg tctcctgcct ttgaactgag tcagtggagc     1920

tctactgaat actctacatg gactgagagc cgctggaaag atatccgtgc ccggatattt     1980

ctcatcgcca gcaaagagct tgagttgatc accctgacag tgggcttcgg catcctcatc     2040

ttctccctca tcgtcaccta ctgcatcaat gccaaagctg atgtcctttt cattgctccc     2100

cgggagccag gagctgtgtc atactgagga ggaccccagc ttttcttgcc agctcagcag     2160

ttcacttcct agagcatctg tcccactggg acacaaccac taatttgtca ctggaacctc     2220

cctgggcctg tctcagattg ggattaacat aaaagagtgg aactatccaa aagagacagg     2280

gagaaataaa taaattgcct cccttcctcc gctccccttt cccatcaccc cttccccatt     2340

tcctcttcct tctctactca tgccagattt tgggattaca aatagaagct tcttgctcct     2400

gtttaactcc ctagttaccc accctaattt gcccttcagg acccttctac tttttccttc     2460

ctgccctgta cctctctctg ctcctcaccc ccacccctgt acccagccac cttcctgact     2520

gggaaggaca taaaaggttt aatgtcaggg tcaaactaca ttgagcccct gaggacaggg     2580

gcatctctgg gctgagccta ctgtctcctt cccactgtcc tttctccagg ccctcagatg     2640

gcacattagg gtgggcgtgc tgcgggtggg tatcccacct ccagcccaca gtgctcagtt     2700

gtacttttta ttaagctgta atatctattt ttgtttttgt ctttttcctt tattcttttt     2760

gtaaatatat atataatgag tttcattaaa atagattatc ccaaaaaaaa aaaaaaaaaa     2820

a                                                                     2821


<210>  10
<211>  557
<212>  DNA
<213>  Homo sapiens

<400>  10
aactatccaa aagagacagg gagaaataaa taaattgcct cccttcctcc gctccccttt       60

cccatcaccc cttccccatt tcctcttcct tctctactca tgccagattt tgggattaca      120

aatagaagct tcttgctcct gtttaactcc ctagttaccc accctaattt gcccttcagg      180

acccttctac tttttccttc ctgccctgta cctctctctg ctcctcaccc ccacccctgt      240

acccagccac cttcctgact gggaaggaca taaaaggttt aatgtcaggg tcaaactaca      300

ttgagcccct gaggacaggg gcatctctgg gctgagccta ctgtctcctt cccactgtcc      360

tttctccagg ccctcagatg gcacattagg gtgggcgtgc tgcgggtggg tatcccacct      420

ccagcccaca gtgctcagtt gtacttttta ttaagctgga atatctattt ttgtttttgt      480

ctttttcctt tattcttttt gtaaatatat atataatgag tttcattaaa atagattatc      540

ccacacgaaa aaaaaaa                                                     557


<210>  11
<211>  2805
<212>  DNA
<213>  Homo sapiens

<400>  11
ggctacggca gggggtggct ctggggctga cccgggaagt cggggtctcc ttcgccttct       60

gtctttctgc gtcctactag caggtttgtg caggggaaac tcagtggaga ggaagatata      120

tatcccctta aataaaacag ctccctgtgt tcgcctgctc aacgccactc atcagattgg      180

ctgccagtct tcaattagtg gagacacagg ggttatccac gtagtagaga aagaggagga      240

cctacagtgg gtattgactg atggccccaa ccccccttac atggttctgc tggagagcaa      300

gcattttacc agggatttaa tggagaagct gaaagggaga accagccgaa ttgctggtct      360

tgcagtgtcc ttgaccaagc ccagtcctgc ctcaggcttc tctcctagtg tacagtgccc      420

aaatgatggg tttggtgttt actccaattc ctatgggcca gagtttgctc actgcagaga      480

aatacagtgg aattcgctgg gcaatggttt ggcttatgaa gactttagtt tccccatctt      540

tcttcttgaa gatgaaaatg aaaccaaagt catcaagcag tgctatcaag atcacaacct      600

gagtcagaat ggctcagcac caaccttccc actatgtgcc atgcagctct tttcacacat      660

gcatgctgtc atcagcactg ccacctgcat gcggcgcagc tccatccaaa gcaccttcag      720

catcaaccca gaaatcgtct gtgaccccct gtctgattac aatgtgtgga gcatgctaaa      780

gcctataaat acaactggga cattaaagcc tgacgacagg gttgtggttg ctgccacccg      840

gctggatagt cgttcctttt tctggaatgt ggccccaggg gctgaaagcg cagtggcttc      900

ctttgtcacc cagctggctg ctgctgaagc tttgcaaaag gcacctgatg tgaccaccct      960

gccccgcaat gtcatgtttg tcttctttca aggggaaact tttgactaca ttggcagctc     1020

gaggatggtc tacgatatgg agaagggcaa gtttcccgtg cagttagaga atgttgactc     1080

atttgtggag ctgggacagg tggccttaag aacttcatta gagctttgga tgcacacaga     1140

tcctgtttct cagaaaaatg agtctgtacg gaaccaggtg gaggatctcc tggccacatt     1200

ggagaagagt ggtgctggtg tccctgctgt catcctcagg aggccaaatc agtcccagcc     1260

tctcccacca tcttccctgc agcgatttct tcgagctcga aacatctctg gcgttgttct     1320

ggctgaccac tctggtgcct tccataacaa atattaccag agtatttacg acactgctga     1380

gaacattaat gtgagctatc ccgaatggct gagccctgaa gaggacctga actttgtaac     1440

agacactgcc aaggccctgg cagatgtggc cacggtgctg ggacgtgctc tgtatgagct     1500

tgcaggagga accaacttca gcgacacagt tcaggctgat ccccaaacgg ttacccgcct     1560

gctctatggg ttcctgatta aagccaacaa ctcatggttc cagtctatcc tcaggcagga     1620

cctaaggtcc tacttgggtg acgggcctct tcaacattac atcgctgtct ccagccccac     1680

caacaccact tatgttgtac agtatgcctt ggcaaatttg actggcacag tggtcaacct     1740

cacccgagag cagtgccagg atccaagtaa agtcccaagt gaaaacaagg atctgtatga     1800

gtactcatgg gtccagggcc ctttgcattc taatgagacg gaccgactcc cccggtgtgt     1860

gcgttctact gcacgattag ccagggcctt gtctcctgcc tttgaactga gtcagtggag     1920

ctctactgaa tactctacat ggactgagag ccgctggaaa gatatccgtg cccggatatt     1980

tctcatcgcc agcaaagagc ttgagttgat caccctgaca gtgggcttcg gcatcctcat     2040

cttctccctc atcgtcacct actgcatcaa tgccaaagct gatgtccttt tcattgctcc     2100

ccgggagcca ggagctgtgt catactgagg aggaccccag cttttcttgc cagctcagca     2160

gttcacttcc tagagcatct gtcccactgg gacacaacca ctaatttgtc actggaacct     2220

ccctgggcct gtctcagatt gggattaaca taaaagagtg gaactatcca aaagagacag     2280

ggagaaataa ataaattgcc tcccttcctc cgctcccctt tcccatcacc ccttccccat     2340

ttcctcttcc ttctctactc atgccagatt ttgggattac aaatagaagc ttcttgctcc     2400

tgtttaactc cctagttacc caccctaatt tgcccttcag gacccttcta ctttttcctt     2460

cctgccctgt acctctctct gctcctcacc cccacccctg tacccagcca ccttcctgac     2520

tgggaaggac ataaaaggtt taatgtcagg gtcaaactac attgagcccc tgaggacagg     2580

ggcatctctg ggctgagcct actgtctcct tcccactgtc ctttctccag gccctcagat     2640

ggcacattag ggtgggcgtg ctgcgggtgg gtatcccacc tccagcccac agtgctcagt     2700

tgtacttttt attaagctgt aatatctatt tttgtttttg tctttttcct ttattctttt     2760

tgtaaatata tatataatga gtttcattaa aatagattat cccac                     2805


<210>  12
<211>  467
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Thr Glu Leu Pro Ala Pro Leu Ser Tyr Phe Gln Asn Ala Gln Met 
1               5                   10                  15      


Ser Glu Asp Asn His Leu Ser Asn Thr Val Arg Ser Gln Asn Asp Asn 
            20                  25                  30          


Arg Glu Arg Gln Glu His Asn Asp Arg Arg Ser Leu Gly His Pro Glu 
        35                  40                  45              


Pro Leu Ser Asn Gly Arg Pro Gln Gly Asn Ser Arg Gln Val Val Glu 
    50                  55                  60                  


Gln Asp Glu Glu Glu Asp Glu Glu Leu Thr Leu Lys Tyr Gly Ala Lys 
65                  70                  75                  80  


His Val Ile Met Leu Phe Val Pro Val Thr Leu Cys Met Val Val Val 
                85                  90                  95      


Val Ala Thr Ile Lys Ser Val Ser Phe Tyr Thr Arg Lys Asp Gly Gln 
            100                 105                 110         


Leu Ile Tyr Thr Pro Phe Thr Glu Asp Thr Glu Thr Val Gly Gln Arg 
        115                 120                 125             


Ala Leu His Ser Ile Leu Asn Ala Ala Ile Met Ile Ser Val Ile Val 
    130                 135                 140                 


Val Met Thr Ile Leu Leu Val Val Leu Tyr Lys Tyr Arg Cys Tyr Lys 
145                 150                 155                 160 


Val Ile His Ala Trp Leu Ile Ile Ser Ser Leu Leu Leu Leu Phe Phe 
                165                 170                 175     


Phe Ser Phe Ile Tyr Leu Gly Glu Val Phe Lys Thr Tyr Asn Val Ala 
            180                 185                 190         


Val Asp Tyr Ile Thr Val Ala Leu Leu Ile Trp Asn Phe Gly Val Val 
        195                 200                 205             


Gly Met Ile Ser Ile His Trp Lys Gly Pro Leu Arg Leu Gln Gln Ala 
    210                 215                 220                 


Tyr Leu Ile Met Ile Ser Ala Leu Met Ala Leu Val Phe Ile Lys Tyr 
225                 230                 235                 240 


Leu Pro Glu Trp Thr Ala Trp Leu Ile Leu Ala Val Ile Ser Val Tyr 
                245                 250                 255     


Asp Leu Val Ala Val Leu Cys Pro Lys Gly Pro Leu Arg Met Leu Val 
            260                 265                 270         


Glu Thr Ala Gln Glu Arg Asn Glu Thr Leu Phe Pro Ala Leu Ile Tyr 
        275                 280                 285             


Ser Ser Thr Met Val Trp Leu Val Asn Met Ala Glu Gly Asp Pro Glu 
    290                 295                 300                 


Ala Gln Arg Arg Val Ser Lys Asn Ser Lys Tyr Asn Ala Glu Ser Thr 
305                 310                 315                 320 


Glu Arg Glu Ser Gln Asp Thr Val Ala Glu Asn Asp Asp Gly Gly Phe 
                325                 330                 335     


Ser Glu Glu Trp Glu Ala Gln Arg Asp Ser His Leu Gly Pro His Arg 
            340                 345                 350         


Ser Thr Pro Glu Ser Arg Ala Ala Val Gln Glu Leu Ser Ser Ser Ile 
        355                 360                 365             


Leu Ala Gly Glu Asp Pro Glu Glu Arg Gly Val Lys Leu Gly Leu Gly 
    370                 375                 380                 


Asp Phe Ile Phe Tyr Ser Val Leu Val Gly Lys Ala Ser Ala Thr Ala 
385                 390                 395                 400 


Ser Gly Asp Trp Asn Thr Thr Ile Ala Cys Phe Val Ala Ile Leu Ile 
                405                 410                 415     


Gly Leu Cys Leu Thr Leu Leu Leu Leu Ala Ile Phe Lys Lys Ala Leu 
            420                 425                 430         


Pro Ala Leu Pro Ile Ser Ile Thr Phe Gly Leu Val Phe Tyr Phe Ala 
        435                 440                 445             


Thr Asp Tyr Leu Val Gln Pro Phe Met Asp Gln Leu Ala Phe His Gln 
    450                 455                 460                 


Phe Tyr Ile 
465         


<210>  13
<211>  378
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Thr Glu Leu Pro Ala Pro Leu Ser Tyr Phe Gln Asn Ala Gln Met 
1               5                   10                  15      


Ser Glu Asp Asn His Leu Ser Asn Thr Val Arg Ser Gln Asn Asp Asn 
            20                  25                  30          


Arg Glu Arg Gln Glu His Asn Asp Arg Arg Ser Leu Gly His Pro Glu 
        35                  40                  45              


Pro Leu Ser Asn Gly Arg Pro Gln Gly Asn Ser Arg Gln Val Val Glu 
    50                  55                  60                  


Gln Asp Glu Glu Glu Asp Glu Glu Leu Thr Leu Lys Tyr Gly Ala Lys 
65                  70                  75                  80  


His Val Ile Met Leu Phe Val Pro Val Thr Leu Cys Met Val Val Val 
                85                  90                  95      


Val Ala Thr Ile Lys Ser Val Ser Phe Tyr Thr Arg Lys Asp Gly Gln 
            100                 105                 110         


Leu Ile Tyr Thr Pro Phe Thr Glu Asp Thr Glu Thr Val Gly Gln Gly 
        115                 120                 125             


Ala Leu His Ser Ile Leu Asn Ala Ala Ile Met Ile Ser Val Ile Val 
    130                 135                 140                 


Val Met Thr Ile Leu Leu Val Val Leu Tyr Lys Tyr Arg Cys Tyr Lys 
145                 150                 155                 160 


Val Ile His Ala Trp Leu Ile Ile Ser Ser Leu Leu Leu Leu Phe Phe 
                165                 170                 175     


Phe Ser Phe Ile Tyr Leu Gly Glu Val Phe Lys Thr Tyr Asn Val Ala 
            180                 185                 190         


Val Asp Tyr Ile Thr Val Ala Leu Leu Ile Trp Asn Phe Gly Val Val 
        195                 200                 205             


Gly Met Ile Ser Ile His Trp Lys Gly Pro Leu Arg Leu Gln Gln Ala 
    210                 215                 220                 


Tyr Leu Ile Met Ile Ser Ala Leu Met Ala Leu Val Phe Ile Lys Tyr 
225                 230                 235                 240 


Leu Pro Glu Trp Thr Ala Trp Leu Ile Leu Ala Val Ile Ser Val Tyr 
                245                 250                 255     


Asp Leu Val Ala Val Leu Cys Pro Lys Gly Pro Leu Arg Met Leu Val 
            260                 265                 270         


Glu Thr Ala Gln Glu Arg Asn Glu Thr Leu Phe Pro Ala Leu Ile Tyr 
        275                 280                 285             


Ser Ser Thr Met Val Trp Leu Val Asn Met Ala Glu Gly Asp Pro Glu 
    290                 295                 300                 


Ala Gln Arg Arg Val Ser Lys Asn Ser Lys Tyr Asn Ala Glu Arg Ala 
305                 310                 315                 320 


Cys Leu Pro Pro Ala Ala Ile Asn Leu Leu Ser Ile Ala Pro Met Ala 
                325                 330                 335     


Pro Arg Leu Phe Met Pro Lys Gly Ala Cys Arg Pro Thr Ala Gln Lys 
            340                 345                 350         


Gly Ser His Lys Thr Leu Leu Gln Arg Met Met Met Ala Gly Ser Val 
        355                 360                 365             


Arg Asn Gly Lys Pro Arg Gly Thr Val Ile 
    370                 375             


<210>  14
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Thr Glu Leu Pro Ala Pro Leu Ser Tyr Phe Gln Asn Ala Gln Met 
1               5                   10                  15      


Ser Glu Asp Asn His Leu Ser Asn Thr Val Arg Ser Gln Asn Asp Asn 
            20                  25                  30          


Arg Glu Arg Gln Glu His Asn Asp Arg Arg Ser Leu Gly His Pro Glu 
        35                  40                  45              


Pro Leu Ser Asn Gly Arg Pro Gln Gly Asn Ser Arg Gln Val Val Glu 
    50                  55                  60                  


Gln Asp Glu Glu Glu Asp Glu Glu Leu Thr Leu Lys Tyr Gly Ala Lys 
65                  70                  75                  80  


His Val Ile Met Leu Phe Val Pro Val Thr Leu Cys Met Val Val Val 
                85                  90                  95      


Val Ala Thr Ile Lys Ser Val Ser Phe Tyr Thr Arg Lys Asp Gly Gln 
            100                 105                 110         


Leu Ile Tyr Thr Pro Phe Thr Glu Asp Thr Glu Thr Val Gly Gln Arg 
        115                 120                 125             


Ala Leu His Ser Ile Leu Asn Ala Ala Ile Met Ile Ser Val Ile Val 
    130                 135                 140                 


Val Met Thr Ile Leu Leu Val Val Leu Tyr Lys Tyr Arg Cys Tyr Lys 
145                 150                 155                 160 


Val Ser Met Arg His Arg Ser Leu Leu Ser Thr Leu Phe Phe Leu Trp 
                165                 170                 175     


Leu Gly Ile Leu Val Thr Val Thr 
            180                 


<210>  15
<211>  463
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Thr Glu Leu Pro Ala Pro Leu Ser Tyr Phe Gln Asn Ala Gln Met 
1               5                   10                  15      


Ser Glu Asp Asn His Leu Ser Asn Thr Asn Asp Asn Arg Glu Arg Gln 
            20                  25                  30          


Glu His Asn Asp Arg Arg Ser Leu Gly His Pro Glu Pro Leu Ser Asn 
        35                  40                  45              


Gly Arg Pro Gln Gly Asn Ser Arg Gln Val Val Glu Gln Asp Glu Glu 
    50                  55                  60                  


Glu Asp Glu Glu Leu Thr Leu Lys Tyr Gly Ala Lys His Val Ile Met 
65                  70                  75                  80  


Leu Phe Val Pro Val Thr Leu Cys Met Val Val Val Val Ala Thr Ile 
                85                  90                  95      


Lys Ser Val Ser Phe Tyr Thr Pro Lys Asp Gly Gln Leu Ile Tyr Thr 
            100                 105                 110         


Pro Phe Thr Glu Asp Thr Glu Thr Val Gly Gln Arg Ala Leu His Ser 
        115                 120                 125             


Ile Leu Asn Ala Ala Ile Met Ile Ser Val Ile Val Val Met Thr Ile 
    130                 135                 140                 


Leu Leu Val Val Leu Tyr Lys Tyr Arg Cys Tyr Lys Val Ile His Ala 
145                 150                 155                 160 


Trp Leu Ile Ile Ser Ser Leu Leu Leu Leu Phe Phe Phe Ser Phe Ile 
                165                 170                 175     


Tyr Leu Gly Glu Val Phe Lys Thr Tyr Asn Val Ala Val Asp Tyr Ile 
            180                 185                 190         


Thr Val Ala Leu Leu Ile Trp Asn Phe Gly Val Val Gly Met Ile Ser 
        195                 200                 205             


Ile His Trp Lys Gly Pro Leu Arg Leu Gln Gln Ala Tyr Leu Ile Met 
    210                 215                 220                 


Ile Ser Ala Leu Met Ala Leu Val Phe Ile Lys Tyr Leu Pro Glu Trp 
225                 230                 235                 240 


Thr Ala Trp Leu Ile Leu Ala Val Ile Ser Val Tyr Asp Leu Val Ala 
                245                 250                 255     


Val Leu Cys Pro Lys Gly Pro Leu Arg Met Leu Val Glu Thr Ala Gln 
            260                 265                 270         


Glu Arg Asn Glu Thr Leu Phe Pro Ala Leu Ile Tyr Ser Ser Thr Met 
        275                 280                 285             


Val Trp Leu Val Asn Met Ala Glu Gly Asp Pro Gly Ala Gln Arg Arg 
    290                 295                 300                 


Val Ser Lys Asn Ser Lys Tyr Asn Ala Glu Ser Thr Glu Arg Glu Ser 
305                 310                 315                 320 


Gln Asp Thr Val Ala Glu Asn Asp Asp Gly Gly Phe Ser Glu Glu Trp 
                325                 330                 335     


Glu Ala Gln Arg Asp Ser His Leu Gly Pro His Arg Ser Thr Pro Glu 
            340                 345                 350         


Ser Arg Ala Ala Val Gln Glu Leu Ser Ser Ser Ile Leu Ala Gly Glu 
        355                 360                 365             


Asp Pro Glu Glu Arg Gly Val Lys Leu Gly Leu Gly Asp Phe Ile Phe 
    370                 375                 380                 


Tyr Ser Val Leu Val Gly Lys Ala Ser Ala Thr Ala Ser Gly Asp Trp 
385                 390                 395                 400 


Asn Thr Thr Ile Ala Cys Phe Val Ala Ile Leu Ile Gly Leu Cys Leu 
                405                 410                 415     


Thr Leu Leu Leu Leu Ala Ile Phe Lys Lys Ala Leu Pro Ala Leu Pro 
            420                 425                 430         


Ile Ser Ile Thr Phe Gly Leu Val Phe Tyr Phe Ala Thr Asp Tyr Leu 
        435                 440                 445             


Val Gln Pro Phe Met Asp Gln Leu Ala Phe His Gln Phe Tyr Ile 
    450                 455                 460             


<210>  16
<211>  264
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Thr Glu Leu Pro Ala Pro Leu Ser Tyr Phe Gln Asn Ala Gln Met 
1               5                   10                  15      


Ser Glu Asp Asn His Leu Ser Asn Thr Asn Asp Asn Arg Glu Arg Gln 
            20                  25                  30          


Glu His Asn Asp Arg Arg Ser Leu Gly His Pro Glu Pro Leu Ser Asn 
        35                  40                  45              


Gly Arg Pro Gln Gly Asn Ser Arg Gln Val Val Glu Gln Asp Glu Glu 
    50                  55                  60                  


Glu Asp Glu Glu Leu Thr Leu Lys Tyr Gly Ala Lys His Val Ile Met 
65                  70                  75                  80  


Leu Phe Val Pro Val Thr Leu Cys Met Val Trp Leu Val Asn Met Ala 
                85                  90                  95      


Glu Gly Asn Pro Glu Ala Gln Arg Arg Val Ser Lys Asn Ser Lys Tyr 
            100                 105                 110         


Asn Ala Glu Ser Thr Glu Arg Glu Ser Gln Asp Thr Val Ala Glu Asn 
        115                 120                 125             


Asp Asp Gly Gly Phe Ser Glu Glu Trp Glu Ala Gln Arg Asp Ser His 
    130                 135                 140                 


Leu Gly Pro His Arg Ser Thr Pro Glu Ser Arg Ala Ala Val Gln Glu 
145                 150                 155                 160 


Leu Ser Ser Ser Ile Leu Ala Gly Glu Asp Pro Glu Glu Arg Gly Val 
                165                 170                 175     


Lys Leu Gly Leu Gly Asp Phe Ile Phe Tyr Ser Val Leu Val Gly Lys 
            180                 185                 190         


Ala Ser Ala Thr Ala Ser Gly Asp Trp Asn Thr Thr Ile Ala Cys Phe 
        195                 200                 205             


Val Ala Ile Leu Ile Gly Leu Cys Leu Thr Leu Leu Leu Leu Ala Ile 
    210                 215                 220                 


Phe Lys Lys Ala Leu Pro Ala Leu Pro Ile Ser Ile Thr Phe Gly Leu 
225                 230                 235                 240 


Val Phe Tyr Phe Ala Thr Asp Tyr Leu Val Gln Pro Phe Met Asp Gln 
                245                 250                 255     


Leu Ala Phe His Gln Phe Tyr Ile 
            260                 


<210>  17
<211>  467
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Thr Glu Leu Pro Ala Pro Leu Ser Tyr Phe Gln Asn Ala Gln Met 
1               5                   10                  15      


Ser Glu Asp Asn His Leu Ser Asn Thr Val Arg Ser Gln Asn Asp Asn 
            20                  25                  30          


Arg Glu Arg Gln Glu His Asn Asp Arg Arg Ser Leu Gly His Pro Glu 
        35                  40                  45              


Pro Leu Ser Asn Gly Arg Pro Gln Gly Asn Ser Arg Gln Val Val Glu 
    50                  55                  60                  


Gln Asp Glu Glu Glu Asp Glu Glu Leu Thr Leu Lys Tyr Gly Ala Lys 
65                  70                  75                  80  


His Val Ile Met Leu Phe Val Pro Val Thr Leu Cys Met Val Val Val 
                85                  90                  95      


Val Ala Thr Ile Lys Ser Val Ser Phe Tyr Thr Arg Lys Asp Gly Gln 
            100                 105                 110         


Leu Ile Tyr Thr Pro Phe Thr Glu Asp Thr Glu Thr Val Gly Gln Arg 
        115                 120                 125             


Ala Leu His Ser Ile Leu Asn Ala Ala Ile Met Ile Ser Val Ile Val 
    130                 135                 140                 


Val Met Thr Ile Leu Leu Val Val Leu Tyr Lys Tyr Arg Cys Tyr Lys 
145                 150                 155                 160 


Val Ile His Ala Trp Leu Ile Ile Ser Ser Leu Leu Leu Leu Phe Phe 
                165                 170                 175     


Phe Ser Phe Ile Tyr Leu Gly Glu Val Phe Lys Thr Tyr Asn Val Ala 
            180                 185                 190         


Val Asp Tyr Ile Thr Val Ala Leu Leu Ile Trp Asn Phe Gly Val Val 
        195                 200                 205             


Gly Met Ile Ser Ile His Trp Lys Gly Pro Leu Arg Leu Gln Gln Ala 
    210                 215                 220                 


Tyr Leu Ile Met Ile Ser Ala Leu Met Ala Leu Val Phe Ile Lys Tyr 
225                 230                 235                 240 


Leu Pro Glu Trp Thr Ala Trp Leu Ile Leu Ala Val Ile Ser Val Tyr 
                245                 250                 255     


Asp Leu Val Ala Val Leu Cys Pro Lys Gly Pro Leu Arg Met Leu Val 
            260                 265                 270         


Glu Thr Ala Gln Glu Arg Asn Glu Thr Leu Phe Pro Ala Leu Ile Tyr 
        275                 280                 285             


Ser Ser Thr Met Val Trp Leu Val Asn Met Ala Glu Gly Asp Pro Glu 
    290                 295                 300                 


Ala Gln Arg Arg Val Ser Lys Asn Ser Lys Tyr Asn Ala Glu Ser Thr 
305                 310                 315                 320 


Glu Arg Glu Ser Gln Asp Thr Val Ala Glu Asn Asp Asp Gly Gly Phe 
                325                 330                 335     


Ser Glu Glu Trp Glu Ala Gln Arg Asp Ser His Leu Gly Pro His Arg 
            340                 345                 350         


Ser Thr Pro Glu Ser Arg Ala Ala Val Gln Glu Leu Ser Ser Ser Ile 
        355                 360                 365             


Leu Ala Gly Glu Asp Pro Glu Glu Arg Gly Val Lys Leu Gly Leu Gly 
    370                 375                 380                 


Asp Phe Ile Phe Tyr Ser Val Leu Val Gly Lys Ala Ser Ala Thr Ala 
385                 390                 395                 400 


Ser Gly Asp Trp Asn Thr Thr Ile Ala Cys Phe Val Ala Ile Leu Ile 
                405                 410                 415     


Gly Leu Cys Leu Thr Leu Leu Leu Leu Ala Ile Phe Lys Lys Ala Leu 
            420                 425                 430         


Pro Ala Leu Pro Ile Ser Ile Thr Phe Gly Leu Val Phe Tyr Phe Ala 
        435                 440                 445             


Thr Asp Tyr Leu Val Gln Pro Phe Met Asp Gln Leu Ala Phe His Gln 
    450                 455                 460                 


Phe Tyr Ile 
465         


<210>  18
<211>  463
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Thr Glu Leu Pro Ala Pro Leu Ser Tyr Phe Gln Asn Ala Gln Met 
1               5                   10                  15      


Ser Glu Asp Asn His Leu Ser Asn Thr Asn Asp Asn Arg Glu Arg Gln 
            20                  25                  30          


Glu His Asn Asp Arg Arg Ser Leu Gly His Pro Glu Pro Leu Ser Asn 
        35                  40                  45              


Gly Arg Pro Gln Gly Asn Ser Arg Gln Val Val Glu Gln Asp Glu Glu 
    50                  55                  60                  


Glu Asp Glu Glu Leu Thr Leu Lys Tyr Gly Ala Lys His Val Ile Met 
65                  70                  75                  80  


Leu Phe Val Pro Val Thr Leu Cys Met Val Val Val Val Ala Thr Ile 
                85                  90                  95      


Lys Ser Val Ser Phe Tyr Thr Arg Lys Asp Gly Gln Leu Ile Tyr Thr 
            100                 105                 110         


Pro Phe Thr Glu Asp Thr Glu Thr Val Gly Gln Arg Ala Leu His Ser 
        115                 120                 125             


Ile Leu Asn Ala Ala Ile Met Ile Ser Val Ile Val Val Met Thr Ile 
    130                 135                 140                 


Leu Leu Val Val Leu Tyr Lys Tyr Arg Cys Tyr Lys Val Ile His Ala 
145                 150                 155                 160 


Trp Leu Ile Ile Ser Ser Leu Leu Leu Leu Phe Phe Phe Ser Phe Ile 
                165                 170                 175     


Tyr Leu Gly Glu Val Phe Lys Thr Tyr Asn Val Ala Val Asp Tyr Ile 
            180                 185                 190         


Thr Val Ala Leu Leu Ile Trp Asn Phe Gly Val Val Gly Met Ile Ser 
        195                 200                 205             


Ile His Trp Lys Gly Pro Leu Arg Leu Gln Gln Ala Tyr Leu Ile Met 
    210                 215                 220                 


Ile Ser Ala Leu Met Ala Leu Val Phe Ile Lys Tyr Leu Pro Glu Trp 
225                 230                 235                 240 


Thr Ala Trp Leu Ile Leu Ala Val Ile Ser Val Tyr Asp Leu Val Ala 
                245                 250                 255     


Val Leu Cys Pro Lys Gly Pro Leu Arg Met Leu Val Glu Thr Ala Gln 
            260                 265                 270         


Glu Arg Asn Glu Thr Leu Phe Pro Ala Leu Ile Tyr Ser Ser Thr Met 
        275                 280                 285             


Val Trp Leu Val Asn Met Ala Glu Gly Asp Pro Glu Ala Gln Arg Arg 
    290                 295                 300                 


Val Ser Lys Asn Ser Lys Tyr Asn Ala Glu Ser Thr Glu Arg Glu Ser 
305                 310                 315                 320 


Gln Asp Thr Val Ala Glu Asn Asp Asp Gly Gly Phe Ser Glu Glu Trp 
                325                 330                 335     


Glu Ala Gln Arg Asp Ser His Leu Gly Pro His Arg Ser Thr Pro Glu 
            340                 345                 350         


Ser Arg Ala Ala Val Gln Glu Leu Ser Ser Ser Ile Leu Ala Gly Glu 
        355                 360                 365             


Asp Pro Glu Glu Arg Gly Val Lys Leu Gly Leu Gly Asp Phe Ile Phe 
    370                 375                 380                 


Tyr Ser Val Leu Val Gly Lys Ala Ser Ala Thr Ala Ser Gly Asp Trp 
385                 390                 395                 400 


Asn Thr Thr Ile Ala Cys Phe Val Ala Ile Leu Ile Gly Leu Cys Leu 
                405                 410                 415     


Thr Leu Leu Leu Leu Ala Ile Phe Lys Lys Ala Leu Pro Ala Leu Pro 
            420                 425                 430         


Ile Ser Ile Thr Phe Gly Leu Val Phe Tyr Phe Ala Thr Asp Tyr Leu 
        435                 440                 445             


Val Gln Pro Phe Met Asp Gln Leu Ala Phe His Gln Phe Tyr Ile 
    450                 455                 460             


<210>  19
<211>  467
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Thr Glu Leu Pro Ala Pro Leu Ser Tyr Phe Gln Asn Ala Gln Met 
1               5                   10                  15      


Ser Glu Asp Asn His Leu Ser Asn Thr Val Arg Ser Gln Asn Asp Asn 
            20                  25                  30          


Arg Glu Arg Gln Glu His Asn Asp Arg Arg Ser Leu Gly His Pro Glu 
        35                  40                  45              


Pro Leu Ser Asn Gly Arg Pro Gln Gly Asn Ser Arg Gln Val Val Glu 
    50                  55                  60                  


Gln Asp Glu Glu Glu Asp Glu Glu Leu Thr Leu Lys Tyr Gly Ala Lys 
65                  70                  75                  80  


His Val Ile Met Leu Phe Val Pro Val Thr Leu Cys Met Val Val Val 
                85                  90                  95      


Val Ala Thr Ile Lys Ser Val Ser Phe Tyr Thr Arg Lys Asp Gly Gln 
            100                 105                 110         


Leu Ile Tyr Thr Pro Phe Thr Glu Asp Thr Glu Thr Val Gly Gln Arg 
        115                 120                 125             


Ala Leu His Ser Ile Leu Asn Ala Ala Ile Met Ile Ser Val Ile Val 
    130                 135                 140                 


Val Met Thr Ile Leu Leu Val Val Leu Tyr Lys Tyr Arg Cys Tyr Lys 
145                 150                 155                 160 


Val Ile His Ala Trp Leu Ile Ile Ser Ser Leu Leu Leu Leu Phe Phe 
                165                 170                 175     


Phe Ser Phe Ile Tyr Leu Gly Glu Val Phe Lys Thr Tyr Asn Val Ala 
            180                 185                 190         


Val Asp Tyr Ile Thr Val Ala Leu Leu Ile Trp Asn Phe Gly Val Val 
        195                 200                 205             


Gly Met Ile Ser Ile His Trp Lys Gly Pro Leu Arg Leu Gln Gln Ala 
    210                 215                 220                 


Tyr Leu Ile Met Ile Ser Ala Leu Met Ala Leu Val Phe Ile Lys Tyr 
225                 230                 235                 240 


Leu Pro Glu Trp Thr Ala Trp Leu Ile Leu Ala Val Ile Ser Val Tyr 
                245                 250                 255     


Asp Leu Val Ala Val Leu Cys Pro Lys Gly Pro Leu Arg Met Leu Val 
            260                 265                 270         


Glu Thr Ala Gln Glu Arg Asn Glu Thr Leu Phe Pro Ala Leu Ile Tyr 
        275                 280                 285             


Ser Ser Thr Met Val Trp Leu Val Asn Met Ala Glu Gly Asp Pro Glu 
    290                 295                 300                 


Ala Gln Arg Arg Val Ser Lys Asn Ser Lys Tyr Asn Ala Glu Ser Thr 
305                 310                 315                 320 


Glu Arg Glu Ser Gln Asp Thr Val Ala Glu Asn Asp Asp Gly Gly Phe 
                325                 330                 335     


Ser Glu Glu Trp Glu Ala Gln Arg Asp Ser His Leu Gly Pro His Arg 
            340                 345                 350         


Ser Thr Pro Glu Ser Arg Ala Ala Val Gln Glu Leu Ser Ser Ser Ile 
        355                 360                 365             


Leu Ala Gly Glu Asp Pro Glu Glu Arg Gly Val Lys Leu Gly Leu Gly 
    370                 375                 380                 


Asp Phe Ile Phe Tyr Ser Val Leu Val Gly Lys Ala Ser Ala Thr Ala 
385                 390                 395                 400 


Ser Gly Asp Trp Asn Thr Thr Ile Ala Cys Phe Val Ala Ile Leu Ile 
                405                 410                 415     


Gly Leu Cys Leu Thr Leu Leu Leu Leu Ala Ile Phe Lys Lys Ala Leu 
            420                 425                 430         


Pro Ala Leu Pro Ile Ser Ile Thr Phe Gly Leu Val Phe Tyr Phe Ala 
        435                 440                 445             


Thr Asp Tyr Leu Val Gln Pro Phe Met Asp Gln Leu Ala Phe His Gln 
    450                 455                 460                 


Phe Tyr Ile 
465         


<210>  20
<211>  463
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Thr Glu Leu Pro Ala Pro Leu Ser Tyr Phe Gln Asn Ala Gln Met 
1               5                   10                  15      


Ser Glu Asp Asn His Leu Ser Asn Thr Asn Asp Asn Arg Glu Arg Gln 
            20                  25                  30          


Glu His Asn Asp Arg Arg Ser Leu Gly His Pro Glu Pro Leu Ser Asn 
        35                  40                  45              


Gly Arg Pro Gln Gly Asn Ser Arg Gln Val Val Glu Gln Asp Glu Glu 
    50                  55                  60                  


Glu Asp Glu Glu Leu Thr Leu Lys Tyr Gly Ala Lys His Val Ile Met 
65                  70                  75                  80  


Leu Phe Val Pro Val Thr Leu Cys Met Val Val Val Val Ala Thr Ile 
                85                  90                  95      


Lys Ser Val Ser Phe Tyr Thr Arg Lys Asp Gly Gln Leu Ile Tyr Thr 
            100                 105                 110         


Pro Phe Thr Glu Asp Thr Glu Thr Val Gly Gln Arg Ala Leu His Ser 
        115                 120                 125             


Ile Leu Asn Ala Ala Ile Met Ile Ser Val Ile Val Val Met Thr Ile 
    130                 135                 140                 


Leu Leu Val Val Leu Tyr Lys Tyr Arg Cys Tyr Lys Val Ile His Ala 
145                 150                 155                 160 


Trp Leu Ile Ile Ser Ser Leu Leu Leu Leu Phe Phe Phe Ser Phe Ile 
                165                 170                 175     


Tyr Leu Gly Glu Val Phe Lys Thr Tyr Asn Val Ala Val Asp Tyr Ile 
            180                 185                 190         


Thr Val Ala Leu Leu Ile Trp Asn Leu Gly Val Val Gly Met Ile Ser 
        195                 200                 205             


Ile His Trp Lys Gly Pro Leu Arg Leu Gln Gln Ala Tyr Leu Ile Met 
    210                 215                 220                 


Ile Ser Ala Leu Met Ala Leu Val Phe Ile Lys Tyr Leu Pro Glu Trp 
225                 230                 235                 240 


Thr Ala Trp Leu Ile Leu Ala Val Ile Ser Val Tyr Asp Leu Val Ala 
                245                 250                 255     


Val Leu Cys Pro Lys Gly Pro Leu Arg Met Leu Val Glu Thr Ala Gln 
            260                 265                 270         


Glu Arg Asn Glu Thr Leu Phe Pro Ala Leu Ile Tyr Ser Ser Thr Met 
        275                 280                 285             


Val Trp Leu Val Asn Met Ala Glu Gly Asp Pro Glu Ala Gln Arg Arg 
    290                 295                 300                 


Val Ser Lys Asn Ser Lys Tyr Asn Ala Glu Ser Thr Glu Arg Glu Ser 
305                 310                 315                 320 


Gln Asp Thr Val Ala Glu Asn Asp Asp Gly Gly Phe Ser Glu Glu Trp 
                325                 330                 335     


Glu Ala Gln Arg Asp Ser His Leu Gly Pro His Arg Ser Thr Pro Glu 
            340                 345                 350         


Ser Arg Ala Ala Val Gln Glu Leu Ser Ser Ser Ile Leu Ala Gly Glu 
        355                 360                 365             


Asp Pro Glu Glu Arg Gly Val Lys Leu Gly Leu Gly Asp Phe Ile Phe 
    370                 375                 380                 


Tyr Ser Val Leu Val Gly Lys Ala Ser Ala Thr Ala Ser Gly Asp Trp 
385                 390                 395                 400 


Asn Thr Thr Ile Ala Cys Phe Val Ala Ile Leu Ile Gly Leu Cys Leu 
                405                 410                 415     


Thr Leu Leu Leu Leu Ala Ile Phe Lys Lys Ala Leu Pro Ala Leu Pro 
            420                 425                 430         


Ile Ser Ile Thr Phe Gly Leu Val Phe Tyr Phe Ala Thr Asp Tyr Leu 
        435                 440                 445             


Val Gln Pro Phe Met Asp Gln Leu Ala Phe His Gln Phe Tyr Ile 
    450                 455                 460             


<210>  21
<211>  463
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Thr Glu Leu Pro Ala Pro Leu Ser Tyr Phe Gln Asn Ala Gln Met 
1               5                   10                  15      


Ser Glu Asp Asn His Leu Ser Asn Thr Asn Asp Asn Arg Glu Arg Gln 
            20                  25                  30          


Glu His Asn Asp Arg Arg Ser Leu Gly His Pro Glu Pro Leu Ser Asn 
        35                  40                  45              


Gly Arg Pro Gln Gly Asn Ser Arg Gln Val Val Glu Gln Asp Glu Glu 
    50                  55                  60                  


Glu Asp Glu Glu Leu Thr Leu Lys Tyr Gly Ala Lys His Val Ile Met 
65                  70                  75                  80  


Leu Phe Val Pro Val Thr Leu Cys Met Val Val Val Val Ala Thr Ile 
                85                  90                  95      


Lys Ser Val Ser Phe Tyr Thr Arg Lys Asp Gly Gln Leu Ile Tyr Thr 
            100                 105                 110         


Pro Phe Thr Glu Asp Thr Glu Thr Val Gly Gln Arg Ala Leu His Ser 
        115                 120                 125             


Ile Leu Asn Ala Ala Ile Met Ile Ser Val Ile Val Val Met Thr Ile 
    130                 135                 140                 


Leu Leu Val Val Leu Tyr Lys Tyr Arg Cys Tyr Lys Val Ile His Ala 
145                 150                 155                 160 


Trp Leu Ile Ile Ser Ser Leu Leu Leu Leu Phe Phe Phe Ser Phe Ile 
                165                 170                 175     


Tyr Leu Gly Glu Val Phe Lys Thr Tyr Asn Val Ala Val Asp Tyr Ile 
            180                 185                 190         


Thr Val Ala Leu Leu Ile Trp Asn Phe Gly Val Val Gly Met Ile Ser 
        195                 200                 205             


Ile His Trp Lys Gly Pro Leu Arg Leu Gln Gln Ala Tyr Leu Ile Met 
    210                 215                 220                 


Ile Ser Ala Leu Met Ala Leu Val Phe Ile Lys Tyr Leu Pro Glu Trp 
225                 230                 235                 240 


Thr Ala Trp Leu Ile Leu Ala Val Ile Ser Val Tyr Asp Leu Val Ala 
                245                 250                 255     


Val Leu Cys Pro Lys Gly Pro Leu Arg Met Leu Val Glu Thr Ala Gln 
            260                 265                 270         


Glu Arg Asn Glu Thr Leu Phe Pro Ala Leu Ile Tyr Ser Ser Thr Met 
        275                 280                 285             


Val Trp Leu Val Asn Met Ala Glu Gly Asp Pro Glu Ala Gln Arg Arg 
    290                 295                 300                 


Val Ser Lys Asn Ser Lys Tyr Asn Ala Glu Ser Thr Glu Arg Glu Ser 
305                 310                 315                 320 


Gln Asp Thr Val Ala Glu Asn Asp Asp Gly Gly Phe Ser Glu Glu Trp 
                325                 330                 335     


Glu Ala Gln Arg Asp Ser His Leu Gly Pro His Arg Ser Thr Pro Glu 
            340                 345                 350         


Ser Arg Ala Ala Val Gln Glu Leu Ser Ser Ser Ile Leu Ala Gly Glu 
        355                 360                 365             


Asp Pro Glu Glu Arg Gly Val Lys Leu Gly Leu Gly Asp Phe Ile Phe 
    370                 375                 380                 


Tyr Ser Val Leu Val Gly Lys Ala Ser Ala Thr Ala Ser Gly Asp Trp 
385                 390                 395                 400 


Asn Thr Thr Ile Ala Cys Phe Val Ala Ile Leu Ile Gly Leu Cys Leu 
                405                 410                 415     


Thr Leu Leu Leu Leu Ala Ile Phe Lys Lys Ala Leu Pro Ala Leu Pro 
            420                 425                 430         


Ile Ser Ile Thr Phe Gly Leu Val Phe Tyr Phe Ala Thr Asp Tyr Leu 
        435                 440                 445             


Val Gln Pro Phe Met Asp Gln Leu Ala Phe His Gln Phe Tyr Ile 
    450                 455                 460             


<210>  22
<211>  374
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Thr Glu Leu Pro Ala Pro Leu Ser Tyr Phe Gln Asn Ala Gln Met 
1               5                   10                  15      


Ser Glu Asp Asn His Leu Ser Asn Thr Asn Asp Asn Arg Glu Arg Gln 
            20                  25                  30          


Glu His Asn Asp Arg Arg Ser Leu Gly His Pro Glu Pro Leu Ser Asn 
        35                  40                  45              


Gly Arg Pro Gln Gly Asn Ser Arg Gln Val Val Glu Gln Asp Glu Glu 
    50                  55                  60                  


Glu Asp Glu Glu Leu Thr Leu Lys Tyr Gly Ala Lys His Val Ile Met 
65                  70                  75                  80  


Leu Phe Val Pro Val Thr Leu Cys Met Val Val Val Val Ala Thr Ile 
                85                  90                  95      


Lys Ser Val Ser Phe Tyr Thr Arg Lys Asp Gly Gln Leu Ile Tyr Thr 
            100                 105                 110         


Pro Phe Thr Glu Asp Thr Glu Thr Val Gly Gln Arg Ala Leu His Ser 
        115                 120                 125             


Ile Leu Asn Ala Ala Ile Met Ile Ser Val Ile Val Val Met Thr Ile 
    130                 135                 140                 


Leu Leu Val Val Leu Tyr Lys Tyr Arg Cys Tyr Lys Val Ile His Ala 
145                 150                 155                 160 


Trp Leu Ile Ile Ser Ser Leu Leu Leu Leu Phe Phe Phe Ser Phe Ile 
                165                 170                 175     


Tyr Leu Gly Glu Val Phe Lys Thr Tyr Asn Val Ala Val Asp Tyr Ile 
            180                 185                 190         


Thr Val Ala Leu Leu Ile Trp Asn Phe Gly Val Val Gly Met Ile Ser 
        195                 200                 205             


Ile His Trp Lys Gly Pro Leu Arg Leu Gln Gln Ala Tyr Leu Ile Met 
    210                 215                 220                 


Ile Ser Ala Leu Met Ala Leu Val Phe Ile Lys Tyr Leu Pro Glu Trp 
225                 230                 235                 240 


Thr Ala Trp Leu Ile Leu Ala Val Ile Ser Val Tyr Asp Leu Val Ala 
                245                 250                 255     


Val Leu Cys Pro Lys Gly Pro Leu Arg Met Leu Val Glu Thr Ala Gln 
            260                 265                 270         


Glu Arg Asn Glu Thr Leu Phe Pro Ala Leu Ile Tyr Ser Ser Thr Met 
        275                 280                 285             


Val Trp Leu Val Asn Met Ala Glu Gly Asp Pro Glu Ala Gln Arg Arg 
    290                 295                 300                 


Val Ser Lys Asn Ser Lys Tyr Asn Ala Glu Arg Ala Cys Leu Pro Pro 
305                 310                 315                 320 


Ala Ala Ile Asn Leu Leu Ser Ile Ala Pro Met Ala Pro Arg Leu Phe 
                325                 330                 335     


Met Pro Lys Gly Ala Cys Arg Pro Thr Ala Gln Lys Gly Ser His Lys 
            340                 345                 350         


Thr Leu Leu Gln Arg Met Met Met Ala Gly Ser Val Arg Asn Gly Lys 
        355                 360                 365             


Pro Arg Gly Thr Val Ile 
    370                 


<210>  23
<211>  463
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Thr Glu Leu Pro Ala Pro Leu Ser Tyr Phe Gln Asn Ala Gln Met 
1               5                   10                  15      


Ser Glu Asp Asn His Leu Ser Asn Thr Asn Asp Asn Arg Glu Arg Gln 
            20                  25                  30          


Glu His Asn Asp Arg Arg Ser Leu Gly His Pro Glu Pro Leu Ser Asn 
        35                  40                  45              


Gly Arg Pro Gln Gly Asn Ser Arg Gln Val Val Glu Gln Asp Glu Glu 
    50                  55                  60                  


Glu Asp Glu Glu Leu Thr Leu Lys Tyr Gly Ala Lys His Val Ile Met 
65                  70                  75                  80  


Leu Phe Val Pro Val Thr Leu Cys Met Val Val Val Val Ala Thr Ile 
                85                  90                  95      


Lys Ser Val Ser Phe Tyr Thr Arg Lys Asp Gly Gln Leu Ile Tyr Thr 
            100                 105                 110         


Pro Phe Thr Glu Asp Thr Glu Thr Val Gly Gln Arg Ala Leu His Ser 
        115                 120                 125             


Ile Leu Asn Ala Ala Ile Met Ile Ser Val Ile Val Val Met Thr Ile 
    130                 135                 140                 


Leu Leu Val Val Leu Tyr Lys Tyr Arg Cys Tyr Lys Val Ile His Ala 
145                 150                 155                 160 


Trp Leu Ile Ile Ser Ser Leu Leu Leu Leu Phe Phe Phe Ser Phe Ile 
                165                 170                 175     


Tyr Leu Gly Glu Val Phe Lys Thr Tyr Asn Val Ala Val Asp Tyr Ile 
            180                 185                 190         


Thr Val Ala Leu Leu Ile Trp Asn Phe Gly Val Val Gly Met Ile Ser 
        195                 200                 205             


Ile His Trp Lys Gly Pro Leu Arg Leu Gln Gln Ala Tyr Leu Ile Met 
    210                 215                 220                 


Ile Ser Ala Leu Met Ala Leu Val Phe Ile Lys Tyr Leu Pro Glu Trp 
225                 230                 235                 240 


Thr Ala Trp Leu Ile Leu Ala Val Ile Ser Val Tyr Asp Leu Val Ala 
                245                 250                 255     


Val Leu Cys Pro Lys Gly Pro Leu Arg Met Leu Val Glu Thr Ala Gln 
            260                 265                 270         


Glu Arg Asn Glu Thr Leu Phe Pro Ala Leu Ile Tyr Ser Ser Thr Met 
        275                 280                 285             


Val Trp Leu Val Asn Met Ala Glu Gly Asp Pro Glu Ala Gln Arg Arg 
    290                 295                 300                 


Val Ser Lys Asn Ser Lys Tyr Asn Ala Glu Ser Thr Glu Arg Glu Ser 
305                 310                 315                 320 


Gln Asp Thr Val Ala Glu Asn Asp Asp Gly Gly Phe Ser Glu Glu Trp 
                325                 330                 335     


Glu Ala Gln Arg Asp Ser His Leu Gly Pro His Arg Ser Thr Pro Glu 
            340                 345                 350         


Ser Arg Ala Ala Val Gln Glu Leu Ser Ser Ser Ile Leu Ala Gly Glu 
        355                 360                 365             


Asp Pro Glu Glu Arg Gly Val Lys Leu Gly Leu Gly Asp Phe Ile Phe 
    370                 375                 380                 


Tyr Ser Val Leu Val Gly Lys Ala Ser Ala Thr Ala Ser Gly Asp Trp 
385                 390                 395                 400 


Asn Thr Thr Ile Ala Cys Phe Val Ala Ile Leu Ile Gly Leu Cys Leu 
                405                 410                 415     


Thr Leu Leu Leu Leu Ala Ile Phe Lys Lys Ala Leu Pro Ala Leu Pro 
            420                 425                 430         


Ile Ser Ile Thr Phe Gly Leu Val Phe Tyr Phe Ala Thr Asp Tyr Leu 
        435                 440                 445             


Val Gln Pro Phe Met Asp Gln Leu Ala Phe His Gln Phe Tyr Ile 
    450                 455                 460             


<210>  24
<211>  448
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Leu Thr Phe Met Ala Ser Asp Ser Glu Glu Glu Val Cys Asp Glu 
1               5                   10                  15      


Arg Thr Ser Leu Met Ser Ala Glu Ser Pro Thr Pro Arg Ser Cys Gln 
            20                  25                  30          


Glu Gly Arg Gln Gly Pro Glu Asp Gly Glu Asn Thr Ala Gln Trp Arg 
        35                  40                  45              


Ser Gln Glu Asn Glu Glu Asp Gly Glu Glu Asp Pro Asp Arg Tyr Val 
    50                  55                  60                  


Cys Ser Gly Val Pro Gly Arg Pro Pro Gly Leu Glu Glu Glu Leu Thr 
65                  70                  75                  80  


Leu Lys Tyr Gly Ala Lys His Val Ile Met Leu Phe Val Pro Val Thr 
                85                  90                  95      


Leu Cys Met Ile Val Val Val Ala Thr Ile Lys Ser Val Arg Phe Tyr 
            100                 105                 110         


Thr Glu Lys Asn Gly Gln Leu Ile Tyr Thr Pro Phe Thr Glu Asp Thr 
        115                 120                 125             


Pro Ser Val Gly Gln Arg Leu Leu Asn Ser Val Leu Asn Thr Leu Ile 
    130                 135                 140                 


Met Ile Ser Val Ile Val Val Met Thr Ile Phe Leu Val Val Leu Tyr 
145                 150                 155                 160 


Lys Tyr Arg Cys Tyr Lys Phe Ile His Gly Trp Leu Ile Met Ser Ser 
                165                 170                 175     


Leu Met Leu Leu Phe Leu Phe Thr Tyr Ile Tyr Leu Gly Glu Val Leu 
            180                 185                 190         


Lys Thr Tyr Asn Val Ala Met Asp Tyr Pro Thr Leu Leu Leu Thr Val 
        195                 200                 205             


Trp Asn Phe Gly Ala Val Gly Met Val Cys Ile His Trp Lys Gly Pro 
    210                 215                 220                 


Leu Val Leu Gln Gln Ala Tyr Leu Ile Met Ile Ser Ala Leu Met Ala 
225                 230                 235                 240 


Leu Val Phe Ile Lys Tyr Leu Pro Glu Trp Ser Ala Trp Val Ile Leu 
                245                 250                 255     


Gly Ala Ile Ser Val Tyr Asp Leu Val Ala Val Leu Cys Pro Lys Gly 
            260                 265                 270         


Pro Leu Arg Met Leu Val Glu Thr Ala Gln Glu Arg Asn Glu Pro Ile 
        275                 280                 285             


Phe Pro Ala Leu Ile Tyr Ser Ser Ala Met Val Trp Thr Val Gly Met 
    290                 295                 300                 


Ala Lys Leu Asp Pro Ser Ser Gln Gly Ala Leu Gln Leu Pro Tyr Asp 
305                 310                 315                 320 


Pro Glu Met Glu Glu Asp Ser Tyr Asp Ser Phe Gly Glu Pro Ser Tyr 
                325                 330                 335     


Pro Glu Val Phe Glu Pro Pro Leu Thr Gly Tyr Pro Gly Glu Glu Leu 
            340                 345                 350         


Glu Glu Glu Glu Glu Arg Gly Val Lys Leu Gly Leu Gly Asp Phe Ile 
        355                 360                 365             


Phe Tyr Ser Val Leu Val Gly Lys Ala Ala Ala Thr Gly Ser Gly Asp 
    370                 375                 380                 


Trp Asn Thr Thr Leu Ala Cys Phe Val Ala Ile Leu Ile Gly Leu Cys 
385                 390                 395                 400 


Leu Thr Leu Leu Leu Leu Ala Val Phe Lys Lys Ala Leu Pro Ala Leu 
                405                 410                 415     


Pro Ile Ser Ile Thr Phe Gly Leu Ile Phe Tyr Phe Ser Thr Asp Asn 
            420                 425                 430         


Leu Val Arg Pro Phe Met Asp Thr Leu Ala Ser His Gln Leu Tyr Ile 
        435                 440                 445             


<210>  25
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Leu Thr Phe Met Ala Ser Asp Ser Glu Glu Glu Val Cys Asp Glu 
1               5                   10                  15      


Arg Thr Ser Leu Met Ser Ala Glu Ser Pro Thr Pro Arg Ser Cys Gln 
            20                  25                  30          


Glu Gly Arg Gln Gly Pro Glu Asp Gly Glu Asn Thr Ala Gln Trp Arg 
        35                  40                  45              


Ser Gln Glu Asn Glu Glu Asp Gly Glu Glu Asp Pro Asp Arg Tyr Val 
    50                  55                  60                  


Cys Ser Gly Val Pro Gly Arg Pro Pro Gly Leu Glu Glu Glu Leu Thr 
65                  70                  75                  80  


Leu Lys Tyr Gly Ala Lys His Val Ile Met Leu Phe Val Pro Val Thr 
                85                  90                  95      


Leu Cys Met Ile Val Val Val Ala Thr Ile Lys Ser Val Arg Phe Tyr 
            100                 105                 110         


Thr Glu Lys Asn Gly Gln Leu Ile Tyr Thr Thr Phe Thr Glu Asp Thr 
        115                 120                 125             


Pro Ser Val Gly Gln Arg Leu Leu Asn Ser Val Leu Asn Thr Leu Ile 
    130                 135                 140                 


Met Ile Ser Val Ile Val Val Met Thr Ile Phe Leu Val Val Leu Tyr 
145                 150                 155                 160 


Lys Tyr Arg Cys Tyr Lys Phe Ile His Gly Trp Leu Ile Met Ser Ser 
                165                 170                 175     


Leu Met Leu Leu Phe Leu Phe Thr Tyr Ile Tyr Leu Gly Glu Val Leu 
            180                 185                 190         


Lys Thr Tyr Asn Val Ala Met Asp Tyr Pro Thr Leu Leu Leu Thr Val 
        195                 200                 205             


Trp Asn Phe Gly Ala Val Gly Met Val Cys Ile His Trp Lys Gly Pro 
    210                 215                 220                 


Leu Val Leu Gln Gln Ala Tyr Leu Ile Met Ile Ser Ala Leu Met Ala 
225                 230                 235                 240 


Leu Val Phe Ile Lys Tyr Leu Pro Glu Trp Ser Ala Trp Val Ile Leu 
                245                 250                 255     


Gly Ala Ile Ser Val Tyr Asp Leu Val Ala Val Leu Cys Pro Lys Gly 
            260                 265                 270         


Pro Leu Arg Met Leu Val Glu Thr Ala Gln Glu Arg Asn Glu Pro Ile 
        275                 280                 285             


Phe Pro Ala Leu Ile Tyr Leu Ser Ala Met Val Trp Thr Val Gly Met 
    290                 295                 300                 


Ala Lys Leu Asp Pro Ser Ser Gln Gly Ala Leu Gln Leu Pro Tyr Asp 
305                 310                 315                 320 


Pro Glu Met Glu Glu Asp Ser Tyr Asp Ser Phe Gly Glu Pro Ser Tyr 
                325                 330                 335     


Pro Glu Val Phe Glu Pro Pro Leu Thr Gly Tyr Pro Gly Glu Glu Leu 
            340                 345                 350         


Glu Glu Glu Glu Glu Arg Gly Val Lys Leu Gly Leu Gly Asp Phe Ile 
        355                 360                 365             


Phe Tyr Ser Val Leu Val Gly Lys Ala Ala Ala Thr Gly Ser Gly Asp 
    370                 375                 380                 


Trp Asn Thr Thr Leu Ala 
385                 390 


<210>  26
<211>  447
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Leu Thr Phe Met Ala Ser Asp Ser Glu Glu Glu Val Cys Asp Glu 
1               5                   10                  15      


Arg Thr Ser Leu Met Ser Ala Glu Ser Pro Thr Pro Arg Ser Cys Gln 
            20                  25                  30          


Glu Gly Arg Gln Gly Pro Glu Asp Gly Glu Asn Thr Ala Gln Trp Arg 
        35                  40                  45              


Ser Gln Glu Asn Glu Glu Asp Gly Glu Glu Asp Pro Asp Arg Tyr Val 
    50                  55                  60                  


Cys Ser Gly Val Pro Gly Arg Pro Pro Gly Leu Glu Glu Glu Leu Thr 
65                  70                  75                  80  


Leu Lys Tyr Gly Ala Lys His Val Ile Met Leu Phe Val Pro Val Thr 
                85                  90                  95      


Leu Cys Met Ile Val Val Val Ala Thr Ile Lys Ser Val Arg Phe Tyr 
            100                 105                 110         


Thr Glu Lys Asn Gly Gln Leu Ile Tyr Thr Pro Phe Thr Glu Asp Thr 
        115                 120                 125             


Pro Ser Val Gly Gln Arg Leu Leu Asn Ser Val Leu Asn Thr Leu Ile 
    130                 135                 140                 


Met Ile Ser Val Ile Val Val Met Thr Ile Phe Leu Val Val Leu Tyr 
145                 150                 155                 160 


Lys Tyr Arg Cys Tyr Lys Phe Ile His Gly Trp Leu Ile Met Ser Ser 
                165                 170                 175     


Leu Met Leu Leu Phe Leu Phe Thr Tyr Ile Tyr Leu Gly Glu Val Leu 
            180                 185                 190         


Lys Thr Tyr Asn Val Ala Met Asp Tyr Pro Thr Leu Leu Leu Thr Val 
        195                 200                 205             


Trp Asn Phe Gly Ala Val Gly Met Val Cys Ile His Trp Lys Gly Pro 
    210                 215                 220                 


Leu Val Leu Gln Gln Ala Tyr Leu Ile Met Ile Ser Ala Leu Met Ala 
225                 230                 235                 240 


Leu Val Phe Ile Lys Tyr Leu Pro Glu Trp Ser Ala Trp Val Ile Leu 
                245                 250                 255     


Gly Ala Ile Ser Val Tyr Asp Leu Val Ala Val Leu Cys Pro Lys Gly 
            260                 265                 270         


Pro Leu Arg Met Leu Val Glu Thr Ala Gln Glu Arg Asn Glu Pro Ile 
        275                 280                 285             


Phe Pro Ala Leu Ile Tyr Ser Ser Ala Met Val Trp Thr Val Gly Met 
    290                 295                 300                 


Ala Lys Leu Asp Pro Ser Ser Gln Gly Ala Leu Gln Leu Pro Tyr Asp 
305                 310                 315                 320 


Pro Glu Met Glu Asp Ser Tyr Asp Ser Phe Gly Glu Pro Ser Tyr Pro 
                325                 330                 335     


Glu Val Phe Glu Pro Pro Leu Thr Gly Tyr Pro Gly Glu Glu Leu Glu 
            340                 345                 350         


Glu Glu Glu Glu Arg Gly Val Lys Leu Gly Leu Gly Asp Phe Ile Phe 
        355                 360                 365             


Tyr Ser Val Leu Val Gly Lys Ala Ala Ala Thr Gly Ser Gly Asp Trp 
    370                 375                 380                 


Asn Thr Thr Leu Ala Cys Phe Val Ala Ile Leu Ile Gly Leu Cys Leu 
385                 390                 395                 400 


Thr Leu Leu Leu Leu Ala Val Phe Lys Lys Ala Leu Pro Ala Leu Pro 
                405                 410                 415     


Ile Ser Ile Thr Phe Gly Leu Ile Phe Tyr Phe Ser Thr Asp Asn Leu 
            420                 425                 430         


Val Arg Pro Phe Met Asp Thr Leu Ala Ser His Gln Leu Tyr Ile 
        435                 440                 445         


<210>  27
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Leu Phe Val Pro Val Thr Leu Cys Met Ile Val Val Val Ala Thr 
1               5                   10                  15      


Ile Lys Ser Val Arg Phe Tyr Thr Glu Lys Asn Gly Gln Leu Ile Tyr 
            20                  25                  30          


Thr Pro Phe Thr Glu Asp Thr Pro Ser Val Gly Gln Arg Leu Leu Asn 
        35                  40                  45              


Ser Val Leu Asn Thr Leu Ile Met Ile Ser Val Ile Val Val Met Thr 
    50                  55                  60                  


Ile Phe Leu Val Val Leu Tyr Lys Tyr Arg Cys Tyr Lys Phe Ile His 
65                  70                  75                  80  


Gly Trp Leu Ile Met Ser Ser Leu Met Leu Leu Phe Leu Phe Thr Tyr 
                85                  90                  95      


Ile Tyr Leu Gly Glu Val Leu Lys Thr Tyr Asn Val Ala Met Asp Tyr 
            100                 105                 110         


Pro Thr Leu Leu Leu Thr Val Trp Asn Phe Gly Ala Val Gly Met Val 
        115                 120                 125             


Cys Ile His Trp Lys Gly Pro Leu Val Leu Gln Gln Ala Tyr Leu Ile 
    130                 135                 140                 


Met Ile Ser Ala Leu Met Ala Leu Val Phe Ile Lys Tyr Leu Pro Glu 
145                 150                 155                 160 


Trp Ser Ala Trp Val Ile Leu Gly Ala Ile Ser Val Tyr Asp Leu Val 
                165                 170                 175     


Ala Val Leu Cys Pro Lys Gly Pro Leu Arg Met Leu Val Glu Thr Ala 
            180                 185                 190         


Gln Glu Arg Asn Glu Pro Ile Phe Pro Ala Leu Ile Tyr Ser Ser Ala 
        195                 200                 205             


Met Val Trp Thr Val Gly Met Ala Lys Leu Asp Pro Ser Ser Gln Gly 
    210                 215                 220                 


Ala Leu Gln Leu Pro Tyr Asp Pro Glu Met Glu Glu Asp Ser Tyr Asp 
225                 230                 235                 240 


Ser Phe Gly Glu Pro Ser Tyr Pro Glu Val Phe Glu Pro Pro Leu Thr 
                245                 250                 255     


Gly Tyr Pro Gly Glu Glu Leu Glu Glu Glu Glu Glu Arg Gly Val Lys 
            260                 265                 270         


Leu Gly Leu Gly Asp Phe Ile Phe Tyr Ser Val Leu Val Gly Lys Ala 
        275                 280                 285             


Ala Ala Thr Gly Ser Gly Asp Trp Asn Thr Thr Leu Ala Cys Phe Val 
    290                 295                 300                 


Ala Ile Leu Ile Gly Leu Cys Leu Thr Leu Leu Leu Leu Ala Val Phe 
305                 310                 315                 320 


Lys Lys Ala Leu Pro Ala Leu Pro Ile Ser Ile Thr Phe Gly Leu Ile 
                325                 330                 335     


Phe Tyr Phe Ser Thr Asp Asn Leu Val Arg Pro Phe Met Asp Thr Leu 
            340                 345                 350         


Ala Ser His Gln Leu Tyr Ile 
        355                 


<210>  28
<211>  448
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Leu Thr Phe Met Ala Ser Asp Ser Glu Glu Glu Val Cys Asp Glu 
1               5                   10                  15      


Arg Thr Ser Leu Met Ser Ala Glu Ser Pro Thr Pro Arg Ser Cys Gln 
            20                  25                  30          


Glu Gly Arg Gln Gly Pro Glu Asp Gly Glu Asn Thr Ala Gln Trp Arg 
        35                  40                  45              


Ser Gln Glu Asn Glu Glu Asp Gly Glu Glu Asp Pro Asp Arg Tyr Val 
    50                  55                  60                  


Cys Ser Gly Val Pro Gly Arg Pro Pro Gly Leu Glu Glu Glu Leu Thr 
65                  70                  75                  80  


Leu Lys Tyr Gly Ala Lys His Val Ile Met Leu Phe Val Pro Val Thr 
                85                  90                  95      


Leu Cys Met Ile Val Val Val Ala Thr Ile Lys Ser Val Arg Phe Tyr 
            100                 105                 110         


Thr Glu Lys Asn Gly Gln Leu Ile Tyr Thr Pro Phe Thr Glu Asp Thr 
        115                 120                 125             


Pro Ser Val Gly Gln Arg Leu Leu Asn Ser Val Leu Asn Thr Leu Ile 
    130                 135                 140                 


Met Ile Ser Val Ile Val Val Met Thr Ile Phe Leu Val Val Leu Tyr 
145                 150                 155                 160 


Lys Tyr Arg Cys Tyr Lys Phe Ile His Gly Trp Leu Ile Met Ser Ser 
                165                 170                 175     


Leu Met Leu Leu Phe Leu Phe Thr Tyr Ile Tyr Leu Gly Glu Val Leu 
            180                 185                 190         


Lys Thr Tyr Asn Val Ala Met Asp Tyr Pro Thr Leu Leu Leu Thr Val 
        195                 200                 205             


Trp Asn Phe Gly Ala Val Gly Met Val Cys Ile His Trp Lys Gly Pro 
    210                 215                 220                 


Leu Val Leu Gln Gln Ala Tyr Leu Ile Met Ile Ser Ala Leu Met Ala 
225                 230                 235                 240 


Leu Val Phe Ile Lys Tyr Leu Pro Glu Trp Ser Ala Trp Val Ile Leu 
                245                 250                 255     


Gly Ala Ile Ser Val Tyr Asp Leu Val Ala Val Leu Cys Pro Lys Gly 
            260                 265                 270         


Pro Leu Arg Met Leu Val Glu Thr Ala Gln Glu Arg Asn Glu Pro Ile 
        275                 280                 285             


Phe Pro Ala Leu Ile Tyr Ser Ser Ala Met Val Trp Thr Val Gly Met 
    290                 295                 300                 


Ala Lys Leu Asp Pro Ser Ser Gln Gly Ala Leu Gln Leu Pro Tyr Asp 
305                 310                 315                 320 


Pro Glu Met Glu Glu Asp Ser Tyr Asp Ser Phe Gly Glu Pro Ser Tyr 
                325                 330                 335     


Pro Glu Val Phe Glu Pro Pro Leu Thr Gly Tyr Pro Gly Glu Glu Leu 
            340                 345                 350         


Glu Glu Glu Glu Glu Arg Gly Val Lys Leu Gly Leu Gly Asp Phe Ile 
        355                 360                 365             


Phe Tyr Ser Val Leu Val Gly Lys Ala Ala Ala Thr Gly Ser Gly Asp 
    370                 375                 380                 


Trp Asn Thr Thr Leu Ala Cys Phe Val Ala Ile Leu Ile Gly Leu Cys 
385                 390                 395                 400 


Leu Thr Leu Leu Leu Leu Ala Val Phe Lys Lys Ala Leu Pro Ala Leu 
                405                 410                 415     


Pro Ile Ser Ile Thr Phe Gly Leu Ile Phe Tyr Phe Ser Thr Asp Asn 
            420                 425                 430         


Leu Val Arg Pro Phe Met Asp Thr Leu Ala Ser His Gln Leu Tyr Ile 
        435                 440                 445             


<210>  29
<211>  448
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Leu Thr Phe Met Ala Ser Asp Ser Glu Glu Glu Val Cys Asp Glu 
1               5                   10                  15      


Arg Thr Ser Leu Met Ser Ala Glu Ser Pro Thr Pro Arg Ser Cys Gln 
            20                  25                  30          


Glu Gly Arg Gln Gly Pro Glu Asp Gly Glu Asn Thr Ala Gln Trp Arg 
        35                  40                  45              


Ser Gln Glu Asn Glu Glu Asp Gly Glu Glu Asp Pro Asp Arg Tyr Val 
    50                  55                  60                  


Cys Ser Gly Val Pro Gly Arg Pro Pro Gly Leu Glu Glu Glu Leu Thr 
65                  70                  75                  80  


Leu Lys Tyr Gly Ala Lys His Val Ile Met Leu Phe Val Pro Val Thr 
                85                  90                  95      


Leu Cys Met Ile Val Val Val Ala Thr Ile Lys Ser Val Arg Phe Tyr 
            100                 105                 110         


Thr Glu Lys Asn Gly Gln Leu Ile Tyr Thr Pro Phe Thr Glu Asp Thr 
        115                 120                 125             


Pro Ser Val Gly Gln Arg Leu Leu Asn Ser Val Leu Asn Thr Leu Ile 
    130                 135                 140                 


Met Ile Ser Val Ile Val Val Met Thr Ile Phe Leu Val Val Leu Tyr 
145                 150                 155                 160 


Lys Tyr Arg Cys Tyr Lys Phe Ile His Gly Trp Leu Ile Met Ser Ser 
                165                 170                 175     


Leu Met Leu Leu Phe Leu Phe Thr Tyr Ile Tyr Leu Gly Glu Val Leu 
            180                 185                 190         


Lys Thr Tyr Asn Val Ala Met Asp Tyr Pro Thr Leu Leu Leu Thr Val 
        195                 200                 205             


Trp Asn Phe Gly Ala Val Gly Met Val Cys Ile His Trp Lys Gly Pro 
    210                 215                 220                 


Leu Val Leu Gln Gln Ala Tyr Leu Ile Met Ile Ser Ala Leu Met Ala 
225                 230                 235                 240 


Leu Val Phe Ile Lys Tyr Leu Pro Glu Trp Ser Ala Trp Val Ile Leu 
                245                 250                 255     


Gly Ala Ile Ser Val Tyr Asp Leu Val Ala Val Leu Cys Pro Lys Gly 
            260                 265                 270         


Pro Leu Arg Met Leu Val Glu Thr Ala Gln Glu Arg Asn Glu Pro Ile 
        275                 280                 285             


Phe Pro Ala Leu Ile Tyr Ser Ser Ala Met Val Trp Thr Val Gly Met 
    290                 295                 300                 


Ala Lys Leu Asp Pro Ser Ser Gln Gly Ala Leu Gln Leu Pro Tyr Asp 
305                 310                 315                 320 


Pro Glu Met Glu Glu Asp Ser Tyr Asp Ser Phe Gly Glu Pro Ser Tyr 
                325                 330                 335     


Pro Glu Val Phe Glu Pro Pro Leu Thr Gly Tyr Pro Gly Glu Glu Leu 
            340                 345                 350         


Glu Glu Glu Glu Glu Arg Gly Val Lys Leu Gly Leu Gly Asp Phe Ile 
        355                 360                 365             


Phe Tyr Ser Val Leu Val Gly Lys Ala Ala Ala Thr Gly Ser Gly Asp 
    370                 375                 380                 


Trp Asn Thr Thr Leu Ala Cys Phe Val Ala Ile Leu Ile Gly Leu Cys 
385                 390                 395                 400 


Leu Thr Leu Leu Leu Leu Ala Val Phe Lys Lys Ala Leu Pro Ala Leu 
                405                 410                 415     


Pro Ile Ser Ile Thr Phe Gly Leu Ile Phe Tyr Phe Ser Thr Asp Asn 
            420                 425                 430         


Leu Val Arg Pro Phe Met Asp Thr Leu Ala Ser His Gln Leu Tyr Ile 
        435                 440                 445             


<210>  30
<211>  448
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Leu Thr Phe Met Ala Ser Asp Ser Glu Glu Glu Val Cys Asp Glu 
1               5                   10                  15      


Arg Thr Ser Leu Met Ser Ala Glu Ser Pro Thr Pro Arg Ser Cys Gln 
            20                  25                  30          


Glu Gly Arg Gln Gly Pro Glu Asp Gly Glu Asn Thr Ala Gln Trp Arg 
        35                  40                  45              


Ser Gln Glu Asn Glu Glu Asp Gly Glu Glu Asp Pro Asp Arg Tyr Val 
    50                  55                  60                  


Cys Ser Gly Val Pro Gly Arg Pro Pro Gly Leu Glu Glu Glu Leu Thr 
65                  70                  75                  80  


Leu Lys Tyr Gly Ala Lys His Val Ile Met Leu Phe Val Pro Val Thr 
                85                  90                  95      


Leu Cys Met Ile Val Val Val Ala Thr Ile Lys Ser Val Arg Phe Tyr 
            100                 105                 110         


Thr Glu Lys Asn Gly Gln Leu Ile Tyr Thr Thr Phe Thr Glu Asp Thr 
        115                 120                 125             


Pro Ser Val Gly Gln Arg Leu Leu Asn Ser Val Leu Asn Thr Leu Ile 
    130                 135                 140                 


Met Ile Ser Val Ile Val Val Met Thr Ile Phe Leu Val Val Leu Tyr 
145                 150                 155                 160 


Lys Tyr Arg Cys Tyr Lys Phe Ile His Gly Trp Leu Ile Met Ser Ser 
                165                 170                 175     


Leu Met Leu Leu Phe Leu Phe Thr Tyr Ile Tyr Leu Gly Glu Val Leu 
            180                 185                 190         


Lys Thr Tyr Asn Val Ala Met Asp Tyr Pro Thr Leu Leu Leu Thr Val 
        195                 200                 205             


Trp Asn Phe Gly Ala Val Gly Met Val Cys Ile His Trp Lys Gly Pro 
    210                 215                 220                 


Leu Val Leu Gln Gln Ala Tyr Leu Ile Met Ile Ser Ala Leu Met Ala 
225                 230                 235                 240 


Leu Val Phe Ile Lys Tyr Leu Pro Glu Trp Ser Ala Trp Val Ile Leu 
                245                 250                 255     


Gly Ala Ile Ser Val Tyr Asp Leu Val Ala Val Leu Cys Pro Lys Gly 
            260                 265                 270         


Pro Leu Arg Met Leu Val Glu Thr Ala Gln Glu Arg Asn Glu Pro Ile 
        275                 280                 285             


Phe Pro Ala Leu Ile Tyr Ser Ser Ala Met Val Trp Thr Val Gly Met 
    290                 295                 300                 


Ala Lys Leu Asp Pro Ser Ser Gln Gly Ala Leu Gln Leu Pro Tyr Asp 
305                 310                 315                 320 


Pro Glu Met Glu Glu Asp Ser Tyr Asp Ser Phe Gly Glu Pro Ser Tyr 
                325                 330                 335     


Pro Glu Val Phe Glu Pro Pro Leu Thr Gly Tyr Pro Gly Glu Glu Leu 
            340                 345                 350         


Glu Glu Glu Glu Glu Arg Gly Val Lys Leu Gly Leu Gly Asp Phe Ile 
        355                 360                 365             


Phe Tyr Ser Val Leu Val Gly Lys Ala Ala Ala Thr Gly Ser Gly Asp 
    370                 375                 380                 


Trp Asn Thr Thr Leu Ala Cys Phe Val Ala Ile Leu Ile Gly Leu Cys 
385                 390                 395                 400 


Leu Thr Leu Leu Leu Leu Ala Val Phe Lys Lys Ala Leu Pro Ala Leu 
                405                 410                 415     


Pro Ile Ser Ile Thr Phe Gly Leu Ile Phe Tyr Phe Ser Thr Asp Asn 
            420                 425                 430         


Leu Val Arg Pro Phe Met Asp Thr Leu Ala Ser His Gln Leu Tyr Ile 
        435                 440                 445             


<210>  31
<211>  448
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Leu Thr Phe Met Ala Ser Asp Ser Glu Glu Glu Val Cys Asp Glu 
1               5                   10                  15      


Arg Thr Ser Leu Met Ser Ala Glu Ser Pro Thr Pro Arg Ser Cys Gln 
            20                  25                  30          


Glu Gly Arg Gln Gly Pro Glu Asp Gly Glu Asn Thr Ala Gln Trp Arg 
        35                  40                  45              


Ser Gln Glu Asn Glu Glu Asp Gly Glu Glu Asp Pro Asp Arg Tyr Val 
    50                  55                  60                  


Cys Ser Gly Val Pro Gly Arg Pro Pro Gly Leu Glu Glu Glu Leu Thr 
65                  70                  75                  80  


Leu Lys Tyr Gly Ala Lys His Val Ile Met Leu Phe Val Pro Val Thr 
                85                  90                  95      


Leu Cys Met Ile Val Val Val Ala Thr Ile Lys Ser Val Arg Phe Tyr 
            100                 105                 110         


Thr Glu Lys Asn Gly Gln Leu Ile Tyr Thr Pro Phe Thr Glu Asp Thr 
        115                 120                 125             


Pro Ser Val Gly Gln Arg Leu Leu Asn Ser Val Leu Asn Thr Leu Ile 
    130                 135                 140                 


Met Ile Ser Val Ile Val Val Met Thr Ile Phe Leu Val Val Leu Tyr 
145                 150                 155                 160 


Lys Tyr Arg Cys Tyr Lys Phe Ile His Gly Trp Leu Ile Met Ser Ser 
                165                 170                 175     


Leu Met Leu Leu Phe Leu Phe Thr Tyr Ile Tyr Leu Gly Glu Val Leu 
            180                 185                 190         


Lys Thr Tyr Asn Val Ala Met Asp Tyr Pro Thr Leu Leu Leu Thr Val 
        195                 200                 205             


Trp Asn Phe Gly Ala Val Gly Met Val Cys Ile His Trp Lys Gly Pro 
    210                 215                 220                 


Leu Val Leu Gln Gln Ala Tyr Leu Ile Met Ile Ser Ala Leu Met Ala 
225                 230                 235                 240 


Leu Val Phe Ile Lys Tyr Leu Pro Glu Trp Ser Ala Trp Val Ile Leu 
                245                 250                 255     


Gly Ala Ile Ser Val Tyr Asp Leu Val Ala Val Leu Cys Pro Lys Gly 
            260                 265                 270         


Pro Leu Arg Met Leu Val Glu Thr Ala Gln Glu Arg Asn Glu Pro Ile 
        275                 280                 285             


Phe Pro Ala Leu Ile Tyr Ser Ser Ala Met Val Trp Thr Val Gly Met 
    290                 295                 300                 


Ala Lys Leu Asp Pro Ser Ser Gln Gly Ala Leu Gln Leu Pro Tyr Asp 
305                 310                 315                 320 


Pro Glu Met Glu Glu Asp Ser Tyr Asp Ser Phe Gly Glu Pro Ser Tyr 
                325                 330                 335     


Pro Glu Val Phe Glu Pro Pro Leu Thr Gly Tyr Pro Gly Glu Glu Leu 
            340                 345                 350         


Glu Glu Glu Glu Glu Arg Gly Val Lys Leu Gly Leu Gly Asp Phe Ile 
        355                 360                 365             


Phe Tyr Ser Val Leu Val Gly Lys Ala Ala Ala Thr Gly Ser Gly Asp 
    370                 375                 380                 


Trp Asn Thr Thr Leu Ala Cys Phe Val Ala Ile Leu Ile Gly Leu Cys 
385                 390                 395                 400 


Leu Thr Leu Leu Leu Leu Ala Val Phe Lys Lys Ala Leu Pro Ala Leu 
                405                 410                 415     


Pro Ile Ser Ile Thr Phe Gly Leu Ile Phe Tyr Phe Ser Thr Asp Asn 
            420                 425                 430         


Leu Val Arg Pro Phe Met Asp Thr Leu Ala Ser His Gln Leu Tyr Ile 
        435                 440                 445             


<210>  32
<211>  442
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Leu Thr Phe Met Ala Ser Asp Ser Glu Glu Glu Val Cys Asp Glu 
1               5                   10                  15      


Arg Thr Ser Leu Met Ser Ala Glu Ser Pro Thr Pro Arg Ser Cys Gln 
            20                  25                  30          


Glu Gly Arg Gln Gly Pro Glu Asp Gly Glu Asn Thr Ala Gln Trp Arg 
        35                  40                  45              


Ser Gln Glu Asn Glu Glu Asp Gly Glu Glu Asp Pro Asp Arg Tyr Val 
    50                  55                  60                  


Cys Ser Gly Val Pro Gly Arg Pro Pro Gly Leu Glu Glu Glu Leu Thr 
65                  70                  75                  80  


Leu Lys Tyr Gly Ala Lys His Val Ile Met Leu Phe Val Pro Val Thr 
                85                  90                  95      


Leu Cys Met Ile Val Val Val Ala Thr Ile Lys Ser Val Arg Phe Tyr 
            100                 105                 110         


Thr Glu Lys Asn Gly Gln Leu Ile Tyr Thr Pro Phe Thr Glu Asp Thr 
        115                 120                 125             


Pro Ser Val Gly Gln Arg Leu Leu Asn Ser Val Leu Asn Thr Leu Ile 
    130                 135                 140                 


Met Ile Ser Val Ile Val Val Met Thr Ile Phe Leu Val Val Leu Tyr 
145                 150                 155                 160 


Lys Tyr Arg Cys Tyr Lys Phe Ile His Gly Trp Leu Ile Met Ser Ser 
                165                 170                 175     


Leu Met Leu Leu Phe Leu Phe Thr Tyr Ile Tyr Leu Gly Glu Val Leu 
            180                 185                 190         


Lys Thr Tyr Asn Val Ala Met Asp Tyr Pro Thr Leu Leu Leu Thr Val 
        195                 200                 205             


Trp Asn Phe Gly Ala Val Gly Met Val Cys Ile His Trp Lys Gly Pro 
    210                 215                 220                 


Leu Val Leu Gln Gln Ala Tyr Leu Ile Met Ile Ser Ala Leu Met Ala 
225                 230                 235                 240 


Leu Val Phe Ile Lys Tyr Leu Pro Glu Trp Ser Ala Trp Val Ile Leu 
                245                 250                 255     


Gly Ala Ile Ser Val Tyr Asp Leu Val Ala Val Leu Cys Pro Lys Gly 
            260                 265                 270         


Pro Leu Arg Met Leu Val Glu Thr Ala Gln Glu Arg Asn Glu Pro Ile 
        275                 280                 285             


Phe Pro Ala Leu Ile Tyr Ser Ser Ala Met Val Trp Thr Val Gly Met 
    290                 295                 300                 


Ala Lys Leu Asp Pro Ser Ser Gln Gly Ala Leu Gln Leu Pro Tyr Asp 
305                 310                 315                 320 


Pro Glu Met Glu Asp Ser Tyr Asp Ser Phe Gly Glu Pro Ser Tyr Pro 
                325                 330                 335     


Glu Val Phe Glu Pro Pro Leu Thr Gly Tyr Pro Gly Glu Glu Leu Glu 
            340                 345                 350         


Glu Glu Glu Glu Ser Gln Gly Gly Val Lys Leu Gly Leu Gly Asp Phe 
        355                 360                 365             


Ile Phe Tyr Ser Val Leu Val Gly Lys Ala Ala Ala Thr Gly Ser Gly 
    370                 375                 380                 


Asp Trp Asn Thr Thr Leu Ala Cys Phe Val Ala Ile Leu Ile Gly Leu 
385                 390                 395                 400 


Cys Leu Thr Leu Leu Leu Leu Ala Val Phe Lys Lys Ala Leu Pro Ala 
                405                 410                 415     


Leu Pro Ile Ser Ile Thr Phe Gly Leu Ile Phe Tyr Phe Ser Thr Asp 
            420                 425                 430         


Arg Lys His Ser Arg Phe Ile Gln Met Asn 
        435                 440         


<210>  33
<211>  265
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Gly Ala Ala Val Phe Phe Gly Cys Thr Phe Val Ala Phe Gly Pro 
1               5                   10                  15      


Ala Phe Ala Leu Phe Leu Ile Thr Val Ala Gly Asp Pro Leu Arg Val 
            20                  25                  30          


Ile Ile Leu Val Ala Gly Ala Phe Phe Trp Leu Val Ser Leu Leu Leu 
        35                  40                  45              


Ala Ser Val Val Trp Phe Ile Leu Val His Val Thr Asp Arg Ser Asp 
    50                  55                  60                  


Ala Arg Leu Gln Tyr Gly Leu Leu Ile Phe Gly Ala Ala Val Ser Val 
65                  70                  75                  80  


Leu Leu Gln Glu Val Phe Arg Phe Ala Tyr Tyr Lys Leu Leu Lys Lys 
                85                  90                  95      


Ala Asp Glu Gly Leu Ala Ser Leu Ser Glu Asp Gly Arg Ser Pro Ile 
            100                 105                 110         


Ser Ile Arg Gln Met Ala Tyr Val Ser Gly Leu Ser Phe Gly Ile Ile 
        115                 120                 125             


Ser Gly Val Phe Ser Val Ile Asn Ile Leu Ala Asp Ala Leu Gly Pro 
    130                 135                 140                 


Gly Val Val Gly Ile His Gly Asp Ser Pro Tyr Tyr Phe Leu Thr Ser 
145                 150                 155                 160 


Ala Phe Leu Thr Ala Ala Ile Ile Leu Leu His Thr Phe Trp Gly Val 
                165                 170                 175     


Val Phe Phe Asp Ala Cys Glu Arg Arg Arg Tyr Trp Ala Leu Gly Leu 
            180                 185                 190         


Val Val Gly Ser His Leu Leu Thr Ser Gly Leu Thr Phe Leu Asn Pro 
        195                 200                 205             


Trp Tyr Glu Ala Ser Leu Leu Pro Ile Tyr Ala Val Thr Val Ser Met 
    210                 215                 220                 


Gly Leu Trp Ala Phe Ile Thr Ala Gly Gly Ser Leu Arg Ser Ile Gln 
225                 230                 235                 240 


Arg Ser Leu Leu Cys Arg Arg Gln Glu Asp Ser Arg Val Met Val Tyr 
                245                 250                 255     


Ser Ala Leu Arg Ile Pro Pro Glu Asp 
            260                 265 


<210>  34
<211>  251
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Gly Ala Ala Val Phe Phe Gly Cys Thr Phe Val Ala Phe Gly Pro 
1               5                   10                  15      


Ala Phe Ala Leu Phe Leu Ile Thr Val Ala Gly Asp Pro Leu Arg Val 
            20                  25                  30          


Ile Ile Leu Val Ala Gly Ala Phe Phe Trp Leu Val Ser Leu Leu Leu 
        35                  40                  45              


Ala Ser Val Val Trp Phe Ile Leu Val His Val Thr Asp Arg Ser Asp 
    50                  55                  60                  


Ala Arg Leu Gln Tyr Gly Leu Leu Ile Phe Gly Ala Ala Val Ser Val 
65                  70                  75                  80  


Leu Leu Gln Glu Val Phe Arg Phe Ala Tyr Tyr Lys Leu Leu Lys Lys 
                85                  90                  95      


Ala Asp Glu Gly Leu Ala Ser Leu Ser Glu Asp Gly Arg Ser Pro Ile 
            100                 105                 110         


Ser Ile Arg Gln Met Ala Tyr Val Ser Gly Leu Ser Phe Gly Ile Ile 
        115                 120                 125             


Ser Gly Val Phe Ser Val Ile Asn Ile Leu Ala Asp Ala Leu Gly Pro 
    130                 135                 140                 


Gly Val Val Gly Ile His Gly Asp Ser Pro Tyr Tyr Phe Leu Thr Ser 
145                 150                 155                 160 


Ala Phe Leu Thr Ala Ala Ile Ile Leu Leu His Thr Phe Trp Gly Val 
                165                 170                 175     


Val Phe Phe Asp Ala Cys Glu Arg Arg Arg Tyr Trp Ala Leu Gly Leu 
            180                 185                 190         


Val Val Gly Ser His Leu Leu Thr Ser Gly Leu Thr Phe Leu Asn Pro 
        195                 200                 205             


Trp Tyr Glu Ala Ser Leu Leu Pro Ile Tyr Ala Val Thr Val Ser Met 
    210                 215                 220                 


Gly Leu Trp Ala Phe Ile Thr Ala Gly Gly Ser Leu Arg Ser Ile Gln 
225                 230                 235                 240 


Arg Ser Ser Cys Val Arg Thr Asp Tyr Leu Asp 
                245                 250     


<210>  35
<211>  251
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Gly Ala Ala Val Phe Phe Gly Cys Thr Phe Val Ala Phe Gly Pro 
1               5                   10                  15      


Ala Phe Ala Leu Phe Leu Ile Thr Val Ala Gly Asp Pro Leu Arg Val 
            20                  25                  30          


Ile Ile Leu Val Ala Gly Ala Phe Phe Trp Leu Val Ser Leu Leu Leu 
        35                  40                  45              


Ala Ser Val Val Trp Phe Ile Leu Val His Val Thr Asp Arg Ser Asp 
    50                  55                  60                  


Ala Arg Leu Gln Tyr Gly Leu Leu Ile Phe Gly Ala Ala Val Ser Val 
65                  70                  75                  80  


Leu Leu Gln Glu Val Phe Arg Phe Ala Tyr Tyr Lys Leu Leu Lys Lys 
                85                  90                  95      


Ala Asp Glu Gly Leu Ala Ser Leu Ser Glu Asp Gly Arg Ser Pro Ile 
            100                 105                 110         


Ser Ile Arg Gln Met Ala Tyr Val Ser Gly Leu Ser Phe Gly Ile Ile 
        115                 120                 125             


Ser Gly Val Phe Ser Val Ile Asn Ile Leu Ala Asp Ala Leu Gly Pro 
    130                 135                 140                 


Gly Val Val Gly Ile His Gly Asp Ser Pro Tyr Tyr Phe Leu Thr Ser 
145                 150                 155                 160 


Ala Phe Leu Thr Ala Ala Ile Ile Leu Leu His Thr Phe Trp Gly Val 
                165                 170                 175     


Val Phe Phe Asp Ala Cys Glu Arg Arg Arg Tyr Trp Ala Leu Gly Leu 
            180                 185                 190         


Val Val Gly Ser His Leu Leu Thr Ser Gly Leu Thr Phe Leu Asn Pro 
        195                 200                 205             


Trp Tyr Glu Ala Ser Leu Leu Pro Ile Tyr Ala Val Thr Val Ser Met 
    210                 215                 220                 


Gly Leu Trp Ala Phe Ile Thr Ala Gly Gly Ser Leu Arg Ser Ile Gln 
225                 230                 235                 240 


Arg Ser Ser Cys Val Arg Thr Asp Tyr Leu Asp 
                245                 250     


<210>  36
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Gly Ala Ala Val Phe Phe Gly Cys Thr Phe Val Ala Phe Gly Pro 
1               5                   10                  15      


Ala Phe Ala Leu Phe Leu Ile Thr Val Ala Gly Asp Pro Leu Arg Val 
            20                  25                  30          


Ile Ile Leu Val Ala Gly Ala Phe Phe Trp Leu Val Ser Leu Leu Leu 
        35                  40                  45              


Ala Ser Val Val Trp Phe Ile Leu Val His Val Thr Asp Arg Ser Asp 
    50                  55                  60                  


Ala Arg Leu Gln Tyr Gly Leu Leu Ile Phe Gly Ala Ala Val Ser Val 
65                  70                  75                  80  


Leu Leu Gln Glu Val Phe Arg Phe Ala Tyr Tyr Lys Leu Leu Lys Lys 
                85                  90                  95      


Ala Asp Glu Gly Leu Ala Ser Leu Ser Glu Asp Gly Arg Ser Pro Ile 
            100                 105                 110         


Ser Ile Arg Gln Met Ala Tyr Val Ser Gly Leu Ser Phe Gly Ile Ile 
        115                 120                 125             


Ser Gly Val Phe Ser Val Ile Asn Ile Leu Ala Asp Ala Leu Gly Pro 
    130                 135                 140                 


Gly Val Val Gly Ile His Gly Asp Ser Pro Tyr Tyr Phe Leu Thr Ser 
145                 150                 155                 160 


Ala Phe Leu Thr Ala Ala Ile Ile Leu Leu His Thr Phe Trp Gly Val 
                165                 170                 175     


Val Phe Phe Asp Ala Cys Glu Arg Arg Arg Tyr Trp Ala Leu Gly Leu 
            180                 185                 190         


Val Val Gly Ser His Leu Leu Thr Ser Gly Leu Thr Phe Leu Asn Pro 
        195                 200                 205             


Trp Tyr Glu Ala Ser Leu Leu Pro Ile Tyr Ala Val Thr Val Ser Met 
    210                 215                 220                 


Gly Leu Trp Ala Phe Ile Thr Ala Gly Gly Ser Leu Arg Ser Ile Gln 
225                 230                 235                 240 


Arg Ser Leu Leu Cys Lys Asp 
                245         


<210>  37
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Gly Ala Ala Val Phe Phe Gly Cys Thr Phe Val Ala Phe Gly Pro 
1               5                   10                  15      


Ala Phe Ala Leu Phe Leu Ile Thr Val Ala Gly Asp Pro Leu Arg Val 
            20                  25                  30          


Ile Ile Leu Val Ala Gly Ala Phe Phe Trp Leu Val Ser Leu Leu Leu 
        35                  40                  45              


Ala Ser Val Val Trp Phe Ile Leu Val His Val Thr Asp Arg Ser Asp 
    50                  55                  60                  


Ala Arg Leu Gln Tyr Gly Leu Leu Ile Phe Gly Ala Ala Val Ser Val 
65                  70                  75                  80  


Leu Leu Gln Glu Val Phe Arg Phe Ala Tyr Tyr Lys Leu Leu Lys Lys 
                85                  90                  95      


Ala Asp Glu Gly Leu Ala Ser Leu Ser Glu Asp Gly Arg Ser Pro Ile 
            100                 105                 110         


Ser Ile Arg Gln Met Ala Tyr Val Ser Gly Leu Ser Phe Gly Ile Ile 
        115                 120                 125             


Ser Gly Val Phe Ser Val Ile Asn Ile Leu Ala Asp Ala Leu Gly Pro 
    130                 135                 140                 


Gly Val Val Gly Ile His Gly Asp Ser Pro Tyr Tyr Phe Leu Thr Ser 
145                 150                 155                 160 


Ala Phe Leu Thr Ala Ala Ile Ile Leu Leu His Thr Phe Trp Gly Val 
                165                 170                 175     


Val Phe Phe Asp Ala Cys Glu Arg Arg Arg Tyr Trp Ala Leu Gly Leu 
            180                 185                 190         


Val Val Gly Ser His Leu Leu Thr Ser Gly Leu Thr Phe Leu Asn Pro 
        195                 200                 205             


Trp Tyr Glu Ala Ser Leu Leu Pro Ile Tyr Ala Val Thr Val Ser Met 
    210                 215                 220                 


Gly Leu Trp Ala Phe Ile Thr Ala Gly Gly Ser Leu Arg Ser Ile Gln 
225                 230                 235                 240 


Arg Ser Leu Leu Cys Lys Asp 
                245         


<210>  38
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Gly Ala Ala Val Phe Cys Gly Cys Thr Phe Val Ala Phe Gly Pro 
1               5                   10                  15      


Ala Phe Ala Leu Phe Leu Ile Thr Val Ala Gly Asp Pro Leu Arg Val 
            20                  25                  30          


Ile Ile Leu Val Ala Gly Ala Phe Phe Trp Leu Val Ser Leu Leu Leu 
        35                  40                  45              


Ala Ser Val Val Trp Phe Ile Leu Val His Val Thr Asp Arg Ser Asp 
    50                  55                  60                  


Ala Arg Leu Gln Tyr Gly Leu Leu Ile Phe Gly Ala Ala Val Ser Val 
65                  70                  75                  80  


Leu Leu Gln Glu Val Phe Arg Phe Ala Tyr Tyr Lys Leu Leu Lys Lys 
                85                  90                  95      


Ala Asp Glu Gly Leu Ala Ser Leu Ser Glu Asp Gly Arg Ser Pro Ile 
            100                 105                 110         


Ser Ile Arg Gln Met Ala Tyr Val Ser Gly Leu Ser Phe Gly Ile Ile 
        115                 120                 125             


Ser Gly Val Phe Ser Val Ile Ser Ile Leu Ala Asp Ala Leu Gly Pro 
    130                 135                 140                 


Gly Val Val Gly Ile His Gly Asp Ser Pro Tyr Tyr Phe Leu Thr Ser 
145                 150                 155                 160 


Ala Phe Leu Thr Ala Ala Ile Ile Leu Leu His Thr Phe Trp Gly Val 
                165                 170                 175     


Val Phe Phe Asp Ala Cys Glu Arg Arg Arg Tyr Trp Ala Leu Gly Leu 
            180                 185                 190         


Val Val Gly Ser His Leu Leu Thr Ser Gly Leu Thr Phe Leu Asn Pro 
        195                 200                 205             


Trp Tyr Glu Ala Ser Leu Leu Pro Ile Tyr Ala Val Thr Val Ser Met 
    210                 215                 220                 


Gly Leu Trp Ala Phe Ile Thr Ala Gly Gly Ser Leu Arg Ser Ile Gln 
225                 230                 235                 240 


Arg Ser Leu Leu Cys Lys Asp 
                245         


<210>  39
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Ala Tyr Val Ser Gly Leu Ser Phe Gly Ile Ile Ser Gly Val Phe 
1               5                   10                  15      


Ser Val Ile Asn Ile Leu Ala Asp Ala Leu Gly Pro Gly Val Val Gly 
            20                  25                  30          


Ile His Gly Asp Ser Pro Tyr Tyr Phe Leu Thr Ser Ala Phe Leu Thr 
        35                  40                  45              


Ala Ala Ile Ile Leu Leu His Thr Phe Trp Gly Val Val Phe Phe Asp 
    50                  55                  60                  


Ala Cys Glu Arg Arg Arg Tyr Trp Ala Leu Gly Leu Val Val Gly Ser 
65                  70                  75                  80  


His Leu Leu Thr Ser Gly Leu Thr Phe Leu Asn Pro Trp Tyr Glu Ala 
                85                  90                  95      


Ser Leu Leu Pro Ile Tyr Ala Val Thr Val Ser Met Gly Leu Trp Ala 
            100                 105                 110         


Phe Ile Thr Ala Gly Gly Ser Leu Arg Ser Ile Gln Arg Ser Leu Leu 
        115                 120                 125             


Cys Lys Asp 
    130     


<210>  40
<211>  195
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Gly Ala Ala Val Phe Phe Gly Cys Thr Phe Val Ala Phe Gly Pro 
1               5                   10                  15      


Ala Phe Ala Leu Phe Leu Ile Thr Val Ala Gly Asp Pro Leu Arg Val 
            20                  25                  30          


Ile Ile Leu Val Ala Gly Arg Cys Ser Ala Leu Pro Thr Thr Ser Cys 
        35                  40                  45              


Leu Ile Ser Gly Leu Ser Phe Gly Ile Ile Ser Gly Val Phe Ser Val 
    50                  55                  60                  


Ile Asn Ile Leu Ala Asp Ala Leu Gly Pro Gly Val Val Gly Ile His 
65                  70                  75                  80  


Gly Asp Ser Pro Tyr Tyr Phe Leu Thr Ser Ala Phe Leu Thr Ala Ala 
                85                  90                  95      


Ile Ile Leu Leu His Thr Phe Trp Gly Val Val Phe Phe Asp Ala Cys 
            100                 105                 110         


Glu Arg Arg Arg Tyr Trp Ala Leu Gly Leu Val Val Gly Ser His Leu 
        115                 120                 125             


Leu Thr Ser Gly Leu Thr Phe Leu Asn Pro Trp Tyr Glu Ala Ser Leu 
    130                 135                 140                 


Leu Pro Ile Tyr Ala Val Thr Val Ser Met Gly Leu Trp Ala Phe Ile 
145                 150                 155                 160 


Thr Ala Gly Gly Ser Leu Arg Ser Ile Gln Arg Ser Leu Leu Cys Arg 
                165                 170                 175     


Arg Gln Glu Asp Ser Arg Val Met Val Tyr Ser Ala Leu Arg Ile Pro 
            180                 185                 190         


Pro Glu Asp 
        195 


<210>  41
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Gly Ala Ala Val Phe Phe Gly Cys Thr Phe Val Ala Phe Gly Pro 
1               5                   10                  15      


Ala Phe Ala Leu Phe Leu Ile Thr Val Ala Gly Asp Pro Leu Arg Val 
            20                  25                  30          


Ile Ile Leu Val Ala Gly Ala Phe Phe Trp Leu Val Ser Leu Leu Leu 
        35                  40                  45              


Ala Ser Val Val Trp Phe Ile Leu Val His Val Thr Asp Arg Ser Asp 
    50                  55                  60                  


Ala Arg Leu Gln Tyr Gly Leu Leu Ile Phe Gly Ala Ala Val Ser Val 
65                  70                  75                  80  


Leu Leu Gln Glu Val Phe Arg Phe Ala Tyr Tyr Lys Leu Leu Asn Phe 
                85                  90                  95      


Trp Ser Leu Leu Arg Tyr His Gln Trp Cys Leu Leu Cys Tyr Gln Tyr 
            100                 105                 110         


Phe Gly 
        


<210>  42
<211>  190
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Gly Ala Ala Val Phe Phe Gly Cys Thr Phe Val Ala Phe Gly Pro 
1               5                   10                  15      


Ala Phe Ala Leu Phe Leu Ile Thr Val Ala Gly Asp Pro Leu Arg Val 
            20                  25                  30          


Ile Ile Leu Val Ala Gly Lys Ala Asp Glu Gly Leu Ala Ser Leu Ser 
        35                  40                  45              


Glu Asp Gly Arg Ser Pro Ile Ser Ile Arg Gln Met Ala Tyr Val Ser 
    50                  55                  60                  


Gly Leu Ser Phe Gly Ile Ile Ser Gly Val Phe Ser Val Ile Asn Ile 
65                  70                  75                  80  


Leu Ala Asp Ala Leu Gly Pro Gly Val Val Gly Ile His Gly Asp Ser 
                85                  90                  95      


Pro Tyr Tyr Phe Leu Thr Ser Ala Phe Leu Thr Ala Ala Ile Ile Leu 
            100                 105                 110         


Leu His Thr Phe Trp Gly Val Val Phe Phe Asp Ala Cys Glu Arg Arg 
        115                 120                 125             


Arg Tyr Trp Ala Leu Gly Leu Val Val Gly Ser His Leu Leu Thr Ser 
    130                 135                 140                 


Gly Leu Thr Phe Leu Asn Pro Trp Tyr Glu Ala Ser Leu Leu Pro Ile 
145                 150                 155                 160 


Tyr Ala Val Thr Val Ser Met Gly Leu Trp Ala Phe Ile Thr Ala Gly 
                165                 170                 175     


Gly Ser Leu Arg Ser Ile Gln Arg Ser Leu Leu Cys Lys Asp 
            180                 185                 190 


<210>  43
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Gly Ala Ala Val Phe Phe Gly Cys Thr Phe Val Ala Phe Gly Pro 
1               5                   10                  15      


Ala Phe Ala Leu Phe Leu Ile Thr Val Ala Gly Asp Pro Leu Arg Val 
            20                  25                  30          


Ile Ile Leu Val Ala Gly Ala Phe Phe Trp Leu Val Ser Leu Leu Leu 
        35                  40                  45              


Ala Ser Val Val Trp Phe Ile Leu Val His Val Thr Asp Arg Ser Asp 
    50                  55                  60                  


Ala Arg Leu Gln Tyr Gly Leu Leu Ile Phe Gly Ala Ala Val Ser Val 
65                  70                  75                  80  


Leu Leu Gln Glu Val Phe Arg Phe Ala Tyr Tyr Lys Leu Leu Lys Lys 
                85                  90                  95      


Ala Asp Glu Gly Leu Ala Ser Leu Ser Glu Asp Gly Arg Ser Pro Ile 
            100                 105                 110         


Ser Ile Arg Gln Met Ala Tyr Val Ser Gly Leu Ser Phe Gly Ile Ile 
        115                 120                 125             


Ser Gly Val Phe Ser Val Ile Asn Ile Leu Ala Asp Ala Leu Gly Pro 
    130                 135                 140                 


Gly Val Val Gly Ile His Gly Asp Ser Pro Tyr Tyr Phe Leu Thr Ser 
145                 150                 155                 160 


Ala Phe Leu Thr Ala Ala Ile Ile Leu Leu His Thr Phe Trp Gly Val 
                165                 170                 175     


Val Phe Phe Asp Ala Cys Glu Arg Arg Arg Tyr Trp Ala Leu Gly Leu 
            180                 185                 190         


Val Val Gly Ser His Leu Leu Thr Ser Gly Leu Thr Phe Leu Asn Pro 
        195                 200                 205             


Trp Tyr Glu Ala Ser Leu Leu Pro Ile Tyr Ala Val Thr Val Ser Met 
    210                 215                 220                 


Gly Leu Trp Ala Phe Ile Thr Ala Gly Gly Ser Leu Arg Ser Ile Gln 
225                 230                 235                 240 


Arg Ser Leu Leu Cys Lys Asp 
                245         


<210>  44
<211>  265
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Gly Ala Ala Val Phe Phe Gly Cys Thr Phe Val Ala Phe Gly Pro 
1               5                   10                  15      


Ala Phe Ala Leu Phe Leu Ile Thr Val Ala Gly Asp Pro Leu Arg Val 
            20                  25                  30          


Ile Ile Leu Val Ala Gly Ala Phe Phe Trp Leu Val Ser Leu Leu Leu 
        35                  40                  45              


Ala Ser Val Val Trp Phe Ile Leu Val His Val Thr Asp Arg Ser Asp 
    50                  55                  60                  


Ala Arg Leu Gln Tyr Gly Leu Leu Ile Phe Gly Ala Ala Val Ser Val 
65                  70                  75                  80  


Leu Leu Gln Glu Val Phe Arg Phe Ala Tyr Tyr Lys Leu Leu Lys Lys 
                85                  90                  95      


Ala Asp Glu Gly Leu Ala Ser Leu Ser Glu Asp Gly Arg Ser Pro Ile 
            100                 105                 110         


Ser Ile Arg Gln Met Ala Tyr Val Ser Gly Leu Ser Phe Gly Ile Ile 
        115                 120                 125             


Ser Gly Val Phe Ser Val Ile Asn Ile Leu Ala Asp Ala Leu Gly Pro 
    130                 135                 140                 


Gly Val Val Gly Ile His Gly Asp Ser Pro Tyr Tyr Phe Leu Thr Ser 
145                 150                 155                 160 


Ala Phe Leu Thr Ala Ala Ile Ile Leu Leu His Thr Phe Trp Gly Val 
                165                 170                 175     


Val Phe Phe Asp Ala Cys Glu Arg Arg Arg Tyr Trp Ala Leu Gly Leu 
            180                 185                 190         


Val Val Gly Ser His Leu Leu Thr Ser Gly Leu Thr Phe Leu Asn Pro 
        195                 200                 205             


Trp Tyr Glu Ala Ser Leu Leu Pro Ile Tyr Ala Val Thr Val Ser Met 
    210                 215                 220                 


Gly Leu Trp Ala Phe Ile Thr Ala Gly Gly Ser Leu Arg Ser Ile Gln 
225                 230                 235                 240 


Arg Ser Leu Leu Cys Arg Arg Gln Glu Asp Ser Arg Val Met Val Tyr 
                245                 250                 255     


Ser Ala Leu Arg Ile Pro Pro Glu Asp 
            260                 265 


<210>  45
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Gly Ala Ala Val Phe Phe Gly Cys Thr Phe Val Ala Phe Gly Pro 
1               5                   10                  15      


Ala Phe Ala Leu Phe Leu Ile Thr Val Ala Gly Asp Pro Leu Arg Val 
            20                  25                  30          


Ile Ile Leu Val Ala Gly Ala Phe Phe Trp Leu Val Ser Leu Leu Leu 
        35                  40                  45              


Ala Ser Val Val Trp Phe Ile Leu Val His Val Thr Asp Arg Ser Asp 
    50                  55                  60                  


Ala Arg Leu Gln Tyr Gly Leu Leu Ile Phe Gly Ala Ala Val Ser Val 
65                  70                  75                  80  


Leu Leu Gln Glu Val Phe Arg Phe Ala Tyr Tyr Lys Leu Leu Lys Lys 
                85                  90                  95      


Ala Asp Glu Gly Leu Ala Ser Leu Ser Glu Asp Gly Arg Ser Pro Ile 
            100                 105                 110         


Ser Ile Arg Gln Met Ala Tyr Val Ser Gly Leu Ser Phe Gly Ile Ile 
        115                 120                 125             


Ser Gly Val Phe Ser Val Ile Asn Ile Leu Ala Asp Ala Leu Gly Pro 
    130                 135                 140                 


Gly Val Val Gly Ile His Gly Asp Ser Pro Tyr Tyr Phe Leu Thr Ser 
145                 150                 155                 160 


Ala Phe Leu Thr Ala Ala Ile Ile Leu Leu His Thr Phe Trp Gly Val 
                165                 170                 175     


Val Phe Phe Asp Ala Cys Glu Arg Arg Arg Tyr Trp Ala Leu Gly Leu 
            180                 185                 190         


Val Val Gly Ser His Leu Leu Thr Ser Gly Leu Thr Phe Leu Asn Pro 
        195                 200                 205             


Trp Tyr Glu Ala Ser Leu Leu Pro Ile Tyr Ala Val Thr Val Ser Met 
    210                 215                 220                 


Gly Leu Trp Ala Phe Ile Thr Ala Gly Gly Ser Leu Arg Ser Ile Gln 
225                 230                 235                 240 


Arg Ser Leu Leu Cys Lys Asp 
                245         


<210>  46
<211>  265
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Gly Ala Ala Val Phe Phe Gly Cys Thr Phe Val Ala Phe Gly Pro 
1               5                   10                  15      


Ala Phe Ala Leu Phe Leu Ile Thr Val Ala Gly Asp Pro Leu Arg Val 
            20                  25                  30          


Ile Ile Leu Val Ala Gly Ala Phe Phe Trp Leu Val Ser Leu Leu Leu 
        35                  40                  45              


Ala Ser Val Val Trp Phe Ile Leu Val His Val Thr Asp Arg Ser Asp 
    50                  55                  60                  


Ala Arg Leu Gln Tyr Gly Leu Leu Ile Phe Gly Ala Ala Val Ser Val 
65                  70                  75                  80  


Leu Leu Gln Glu Val Phe Arg Phe Ala Tyr Tyr Lys Leu Leu Lys Lys 
                85                  90                  95      


Ala Asp Glu Gly Leu Ala Ser Leu Ser Glu Asp Gly Arg Ser Pro Ile 
            100                 105                 110         


Ser Ile Arg Gln Met Ala Tyr Val Ser Gly Leu Ser Phe Gly Ile Ile 
        115                 120                 125             


Ser Gly Val Phe Ser Val Ile Asn Ile Leu Ala Asp Ala Leu Gly Pro 
    130                 135                 140                 


Gly Val Val Gly Ile His Gly Asp Ser Pro Tyr Tyr Phe Leu Thr Ser 
145                 150                 155                 160 


Ala Phe Leu Thr Ala Ala Ile Ile Leu Leu His Thr Phe Trp Gly Val 
                165                 170                 175     


Val Phe Phe Asp Ala Cys Glu Arg Arg Arg Tyr Trp Ala Leu Gly Leu 
            180                 185                 190         


Val Val Gly Ser His Leu Leu Thr Ser Gly Leu Thr Phe Leu Asn Pro 
        195                 200                 205             


Trp Tyr Glu Ala Ser Leu Leu Pro Ile Tyr Ala Val Thr Val Ser Met 
    210                 215                 220                 


Gly Leu Trp Ala Phe Ile Thr Ala Gly Gly Ser Leu Arg Ser Ile Gln 
225                 230                 235                 240 


Arg Ser Leu Leu Cys Arg Arg Gln Glu Asp Ser Arg Val Met Val Tyr 
                245                 250                 255     


Ser Ala Leu Arg Ile Pro Pro Glu Asp 
            260                 265 


<210>  47
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Gly Ala Ala Val Phe Phe Gly Cys Thr Phe Val Ala Phe Gly Pro 
1               5                   10                  15      


Ala Phe Ala Leu Phe Leu Ile Thr Val Ala Gly Asp Pro Leu Arg Val 
            20                  25                  30          


Ile Ile Leu Val Ala Gly Ala Phe Phe Trp Leu Val Ser Leu Leu Leu 
        35                  40                  45              


Ala Ser Val Val Trp Phe Ile Leu Val His Val Thr Asp Arg Ser Asp 
    50                  55                  60                  


Ala Arg Leu Gln Tyr Gly Leu Leu Ile Phe Gly Ala Ala Val Ser Val 
65                  70                  75                  80  


Leu Leu Gln Glu Val Phe Arg Phe Ala Tyr Tyr Lys Leu Leu Lys Lys 
                85                  90                  95      


Ala Asp Glu Gly Leu Ala Ser Leu Ser Glu Asp Gly Arg Ser Pro Ile 
            100                 105                 110         


Ser Ile Arg Gln Met Ala Tyr Val Ser Gly Leu Ser Phe Gly Ile Ile 
        115                 120                 125             


Ser Gly Val Phe Ser Val Ile Asn Ile Leu Ala Asp Ala Leu Gly Pro 
    130                 135                 140                 


Gly Val Val Gly Ile His Gly Asp Ser Pro Tyr Tyr Phe Leu Thr Ser 
145                 150                 155                 160 


Ala Phe Leu Thr Ala Ala Ile Ile Leu Leu His Thr Phe Trp Gly Val 
                165                 170                 175     


Val Phe Phe Asp Ala Cys Glu Arg Arg Arg Tyr Trp Ala Leu Gly Leu 
            180                 185                 190         


Val Val Gly Ser His Leu Leu Thr Ser Gly Leu Thr Phe Leu Asn Pro 
        195                 200                 205             


Trp Tyr Glu Ala Ser Leu Leu Pro Ile Tyr Ala Val Thr Val Ser Met 
    210                 215                 220                 


Gly Leu Trp Ala Phe Ile Thr Ala Gly Gly Ser Leu Arg Ser Ile Gln 
225                 230                 235                 240 


Arg Ser Leu Leu Cys Lys Asp 
                245         


<210>  48
<211>  265
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Gly Ala Ala Val Phe Phe Gly Cys Thr Phe Val Ala Phe Gly Pro 
1               5                   10                  15      


Ala Phe Ala Leu Phe Leu Ile Thr Val Ala Gly Asp Pro Leu Arg Val 
            20                  25                  30          


Ile Ile Leu Val Ala Gly Ala Phe Phe Trp Leu Val Ser Leu Leu Leu 
        35                  40                  45              


Ala Ser Val Val Trp Phe Ile Leu Val His Val Thr Asp Arg Ser Asp 
    50                  55                  60                  


Ala Arg Leu Gln Tyr Gly Leu Leu Ile Phe Gly Ala Ala Val Ser Val 
65                  70                  75                  80  


Leu Leu Gln Glu Val Phe Arg Phe Ala Tyr Tyr Lys Leu Leu Lys Lys 
                85                  90                  95      


Ala Asp Glu Gly Leu Ala Ser Leu Ser Glu Asp Gly Arg Ser Pro Ile 
            100                 105                 110         


Ser Ile Arg Gln Met Ala Tyr Val Ser Gly Leu Ser Phe Gly Ile Ile 
        115                 120                 125             


Ser Gly Val Phe Ser Val Ile Asn Ile Leu Ala Asp Ala Leu Gly Pro 
    130                 135                 140                 


Gly Val Val Gly Ile His Gly Asp Ser Pro Tyr Tyr Phe Leu Thr Ser 
145                 150                 155                 160 


Ala Phe Leu Thr Ala Ala Ile Ile Leu Leu His Thr Phe Trp Gly Val 
                165                 170                 175     


Val Phe Phe Asp Ala Cys Glu Arg Arg Arg Tyr Trp Ala Leu Gly Leu 
            180                 185                 190         


Val Val Gly Ser His Leu Leu Thr Ser Gly Leu Thr Phe Leu Asn Pro 
        195                 200                 205             


Trp Tyr Glu Ala Ser Leu Leu Pro Ile Tyr Ala Val Thr Val Ser Met 
    210                 215                 220                 


Gly Leu Trp Ala Phe Ile Thr Ala Gly Gly Ser Ile Arg Ser Ile Gln 
225                 230                 235                 240 


Arg Ser Leu Leu Cys Arg Arg Gln Glu Asp Ser Arg Val Met Val Tyr 
                245                 250                 255     


Ser Ala Leu Arg Ile Pro Pro Glu Asp 
            260                 265 


<210>  49
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Gly Ala Ala Val Phe Phe Gly Cys Thr Phe Val Ala Phe Gly Pro 
1               5                   10                  15      


Ala Phe Ala Leu Phe Leu Ile Thr Val Ala Gly Asp Pro Leu Arg Val 
            20                  25                  30          


Ile Ile Leu Val Ala Gly Ala Phe Phe Trp Leu Val Ser Leu Leu Leu 
        35                  40                  45              


Ala Ser Val Val Trp Phe Ile Leu Val His Val Thr Asp Arg Ser Asp 
    50                  55                  60                  


Ala Arg Leu Gln Tyr Gly Leu Leu Ile Phe Gly Ala Ala Val Ser Val 
65                  70                  75                  80  


Leu Leu Gln Glu Val Phe Arg Phe Ala Tyr Tyr Lys Leu Leu Lys Lys 
                85                  90                  95      


Ala Asp Glu Gly Leu Ala Ser Leu Ser Glu Asp Gly Arg Ser Pro Ile 
            100                 105                 110         


Ser Ile Arg Gln Met Ala Tyr Val Ser Gly Leu Ser Phe Gly Ile Ile 
        115                 120                 125             


Ser Gly Val Phe Ser Val Ile Asn Ile Leu Ala Asp Ala Leu Gly Pro 
    130                 135                 140                 


Gly Val Val Gly Ile His Gly Asp Ser Pro Tyr Tyr Phe Leu Thr Ser 
145                 150                 155                 160 


Ala Phe Leu Thr Ala Ala Ile Ile Leu Leu His Thr Phe Trp Gly Val 
                165                 170                 175     


Val Phe Phe Asp Ala Cys Glu Arg Arg Arg Tyr Trp Ala Leu Gly Leu 
            180                 185                 190         


Val Val Gly Ser His Leu Leu Thr Ser Gly Leu Thr Phe Leu Asn Pro 
        195                 200                 205             


Trp Tyr Glu Ala Ser Leu Leu Pro Ile Tyr Ala Val Thr Val Ser Met 
    210                 215                 220                 


Gly Leu Trp Ala Phe Ile Thr Ala Gly Gly Ser Leu Arg Ser Ile Gln 
225                 230                 235                 240 


Arg Ser Leu Leu Cys Lys Asp 
                245         


<210>  50
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Gly Ala Ala Val Phe Phe Gly Cys Thr Phe Val Ala Phe Gly Pro 
1               5                   10                  15      


Ala Phe Ala Leu Phe Leu Ile Thr Val Ala Gly Asp Pro Leu Arg Val 
            20                  25                  30          


Ile Ile Leu Val Ala Gly Ala Phe Phe Trp Leu Val Ser Leu Leu Leu 
        35                  40                  45              


Ala Ser Val Val Trp Phe Ile Leu Val His Val Thr Asp Arg Ser Asp 
    50                  55                  60                  


Ala Arg Leu Gln Tyr Gly Leu Leu Ile Phe Gly Ala Ala Val Ser Val 
65                  70                  75                  80  


Leu Leu Gln Glu Val Phe Arg Phe Ala Tyr Tyr Lys Leu Leu Lys Lys 
                85                  90                  95      


Ala Asp Glu Gly Leu Ala Ser Leu Ser Glu Asp Gly Arg Ser Pro Ile 
            100                 105                 110         


Ser Ile Arg Gln Met Ala Tyr Val Ser Gly Leu Ser Phe Gly Ile Ile 
        115                 120                 125             


Ser Gly Val Phe Ser Val Ile Asn Ile Leu Ala Asp Ala Leu Gly Pro 
    130                 135                 140                 


Gly Val Val Gly Ile His Gly Asp Ser Pro Tyr Tyr Phe Leu Thr Ser 
145                 150                 155                 160 


Ala Phe Leu Thr Ala Ala Ile Ile Leu Leu His Thr Phe Trp Gly Val 
                165                 170                 175     


Val Phe Phe Asp Ala Cys Glu Arg Arg Arg Tyr Trp Ala Leu Gly Leu 
            180                 185                 190         


Val Val Gly Ser His Leu Leu Thr Ser Gly Leu Thr Phe Leu Asn Pro 
        195                 200                 205             


Trp Tyr Glu Ala Ser Leu Leu Pro Ile Tyr Ala Val Thr Val Ser Met 
    210                 215                 220                 


Gly Leu Trp Ala Phe Ile Thr Ala Gly Gly Ser Leu Arg Ser Ile Gln 
225                 230                 235                 240 


Arg Ser Leu Leu Cys Lys Asp 
                245         


<210>  51
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Thr Ala Ala Val Phe Phe Gly Cys Ala Phe Ile Ala Phe Gly Pro 
1               5                   10                  15      


Ala Leu Ala Leu Tyr Val Phe Thr Ile Ala Thr Glu Pro Leu Arg Ile 
            20                  25                  30          


Ile Phe Leu Ile Ala Gly Ala Phe Phe Trp Leu Val Ser Leu Leu Ile 
        35                  40                  45              


Ser Ser Leu Val Trp Phe Met Ala Arg Val Ile Ile Asp Asn Lys Asp 
    50                  55                  60                  


Gly Pro Thr Gln Lys Tyr Leu Leu Ile Phe Gly Ala Phe Val Ser Val 
65                  70                  75                  80  


Tyr Ile Gln Glu Met Phe Arg Phe Ala Tyr Tyr Lys Leu Leu Lys Lys 
                85                  90                  95      


Ala Ser Glu Gly Leu Lys Ser Ile Asn Pro Gly Glu Thr Ala Pro Ser 
            100                 105                 110         


Met Arg Leu Leu Ala Tyr Val Ser Gly Leu Gly Phe Gly Ile Met Ser 
        115                 120                 125             


Gly Val Phe Ser Phe Val Asn Thr Leu Ser Asp Ser Leu Gly Pro Gly 
    130                 135                 140                 


Thr Val Gly Ile His Gly Asp Ser Pro Gln Phe Phe Leu Tyr Ser Ala 
145                 150                 155                 160 


Phe Met Thr Leu Val Ile Ile Leu Leu His Val Phe Trp Gly Ile Val 
                165                 170                 175     


Phe Phe Asp Gly Cys Glu Lys Lys Lys Trp Gly Ile Leu Leu Ile Val 
            180                 185                 190         


Leu Leu Thr His Leu Leu Val Ser Ala Gln Thr Phe Ile Ser Ser Tyr 
        195                 200                 205             


Tyr Gly Ile Asn Leu Ala Ser Ala Phe Ile Ile Leu Val Leu Met Gly 
    210                 215                 220                 


Thr Trp Ala Phe Leu Ala Ala Gly Gly Ser Cys Arg Ser Leu Lys Leu 
225                 230                 235                 240 


Cys Leu Leu Cys Gln Asp Lys Asn Phe Leu Leu Tyr Asn Gln Arg Ser 
                245                 250                 255     


Arg 
    


<210>  52
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Thr Ala Ala Val Phe Phe Gly Cys Ala Phe Ile Ala Phe Gly Pro 
1               5                   10                  15      


Ala Leu Ala Leu Tyr Val Phe Thr Ile Ala Thr Glu Pro Leu Arg Ile 
            20                  25                  30          


Ile Phe Leu Ile Ala Gly Ala Phe Phe Trp Leu Val Ser Leu Leu Ile 
        35                  40                  45              


Ser Ser Leu Val Trp Phe Met Ala Arg Val Ile Ile Asp Asn Lys Asp 
    50                  55                  60                  


Gly Pro Thr Gln Lys Tyr Leu Leu Ile Phe Gly Ala Phe Val Ser Val 
65                  70                  75                  80  


Tyr Ile Gln Glu Met Phe Arg Phe Ala Tyr Tyr Lys Leu Leu Lys Lys 
                85                  90                  95      


Ala Ser Glu Gly Leu Lys Ser Ile Asn Pro Gly Glu Thr Ala Pro Ser 
            100                 105                 110         


Met Arg Leu Leu Ala Tyr Ala Phe Met Thr Leu Val Ile Ile Leu Leu 
        115                 120                 125             


His Val Phe Trp Gly Ile Val Phe Phe Asp Gly Cys Glu Lys Lys Lys 
    130                 135                 140                 


Trp Gly Ile Leu Leu Ile Val Leu Leu Thr His Leu Leu Val Ser Ala 
145                 150                 155                 160 


Gln Thr Phe Ile Ser Ser Tyr Tyr Gly Ile Asn Leu Ala Ser Ala Phe 
                165                 170                 175     


Ile Ile Leu Val Leu Met Gly Thr Trp Ala Phe Leu Ala Ala Gly Gly 
            180                 185                 190         


Ser Cys Arg Ser Leu Lys Leu Cys Leu Leu Cys Gln Asp Lys Asn Phe 
        195                 200                 205             


Leu Leu Tyr Asn Gln Arg Ser Arg 
    210                 215     


<210>  53
<211>  81
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Thr Ala Ala Val Phe Phe Gly Cys Ala Phe Ile Ala Phe Gly Pro 
1               5                   10                  15      


Ala Leu Ala Leu Tyr Val Phe Thr Ile Ala Thr Glu Pro Leu Arg Ile 
            20                  25                  30          


Ile Phe Leu Ile Ala Gly Arg Arg Val Glu Thr Cys Lys Asn Thr Glu 
        35                  40                  45              


Ala Pro Asp Cys Ala Ser Pro Ser Gly Ser Leu Ser Phe Leu Leu Val 
    50                  55                  60                  


Gly Val Ser Thr Asp Phe Val Pro Cys Leu Val His Gly Lys Ser His 
65                  70                  75                  80  


Tyr 
    


<210>  54
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Thr Ala Ala Val Phe Phe Gly Cys Ala Phe Ile Ala Phe Gly Pro 
1               5                   10                  15      


Ala Leu Ala Leu Tyr Val Phe Thr Ile Ala Thr Glu Pro Leu Arg Ile 
            20                  25                  30          


Ile Phe Leu Ile Ala Gly Ala Phe Phe Trp Leu Val Ser Leu Leu Ile 
        35                  40                  45              


Ser Ser Leu Val Trp Phe Met Ala Arg Val Ile Ile Asp Asn Lys Asp 
    50                  55                  60                  


Gly Pro Thr Gln Lys Tyr Leu Leu Ile Phe Gly Ala Phe Val Ser Val 
65                  70                  75                  80  


Tyr Ile Arg Glu Met Phe Arg Phe Ala Tyr Tyr Lys Leu Leu Lys Lys 
                85                  90                  95      


Ala Ser Glu Gly Leu Lys Ser Ile Asn Pro Gly Glu Thr Ala Pro Ser 
            100                 105                 110         


Met Arg Leu Leu Ala Tyr Val Ser Gly Leu Gly Phe Gly Ile Met Ser 
        115                 120                 125             


Gly Val Phe Ser Phe Val Asn Thr Leu Ser Asp Ser Leu Gly Pro Gly 
    130                 135                 140                 


Thr Val Gly Ile His Gly Asp Ser Pro Gln Phe Phe Leu Tyr Ser Ala 
145                 150                 155                 160 


Phe Met Thr Leu Val Ile Ile Leu Leu His Val Phe Trp Gly Ile Val 
                165                 170                 175     


Phe Phe Asp Gly Cys Glu Lys Lys Lys Trp Gly Ile Leu Leu Ile Val 
            180                 185                 190         


Leu Leu Thr His Leu Leu Val Ser Ala Gln Thr Phe Ile Ser Ser Tyr 
        195                 200                 205             


Tyr Gly Ile Asn Leu Ala Ser Ala Phe Ile Ile Leu Val Leu Met Gly 
    210                 215                 220                 


Thr Trp Ala Phe Leu Ala Ala Gly Gly Ser Cys Arg Ser Leu Lys Leu 
225                 230                 235                 240 


Cys Leu Leu Cys Gln Asp Lys Asn Phe Leu Leu Tyr Asn Gln Arg Ser 
                245                 250                 255     


Arg 
    


<210>  55
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Thr Ala Ala Val Phe Phe Gly Cys Ala Phe Ile Ala Phe Gly Pro 
1               5                   10                  15      


Ala Leu Ala Leu Tyr Val Phe Thr Ile Ala Thr Glu Pro Leu Arg Ile 
            20                  25                  30          


Ile Phe Leu Ile Ala Gly Ala Phe Phe Trp Leu Val Ser Leu Leu Ile 
        35                  40                  45              


Ser Ser Leu Val Trp Phe Met Ala Arg Val Ile Ile Asp Asn Lys Asp 
    50                  55                  60                  


Gly Pro Thr Gln Lys Tyr Leu Leu Ile Phe Gly Ala Phe Val Ser Val 
65                  70                  75                  80  


Tyr Ile Gln Glu Met Phe Arg Phe Ala Tyr Tyr Lys Leu Leu Lys Lys 
                85                  90                  95      


Ala Ser Glu Gly Leu Lys Ser Ile Asn Pro Gly Glu Thr Ala Pro Ser 
            100                 105                 110         


Met Arg Leu Leu Ala Tyr Val Ser Gly Leu Gly Phe Gly Ile Met Ser 
        115                 120                 125             


Gly Val Phe Ser Phe Val Asn Thr Leu Ser Asp Ser Leu Gly Pro Gly 
    130                 135                 140                 


Thr Val Gly Ile His Gly Asp Ser Pro Gln Phe Phe Leu Tyr Ser Ala 
145                 150                 155                 160 


Phe Met Thr Leu Val Ile Ile Leu Leu His Val Phe Trp Gly Ile Val 
                165                 170                 175     


Phe Phe Asp Gly Cys Glu Lys Lys Lys Trp Gly Ile Leu Leu Ile Val 
            180                 185                 190         


Leu Leu Thr His Leu Leu Val Ser Ala Gln Thr Phe Ile Ser Ser Tyr 
        195                 200                 205             


Tyr Gly Ile Asn Leu Ala Ser Ala Phe Ile Ile Leu Val Leu Met Gly 
    210                 215                 220                 


Thr Trp Ala Phe Leu Ala Ala Gly Gly Ser Cys Arg Ser Leu Lys Leu 
225                 230                 235                 240 


Cys Leu Leu Cys Gln Asp Lys Asn Phe Leu Leu Tyr Asn Gln Arg Ser 
                245                 250                 255     


Arg 
    


<210>  56
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Thr Ala Ala Val Phe Phe Gly Cys Ala Phe Ile Ala Phe Gly Pro 
1               5                   10                  15      


Ala Leu Ala Leu Tyr Val Phe Thr Ile Ala Thr Glu Pro Leu Arg Ile 
            20                  25                  30          


Ile Phe Leu Ile Ala Gly Ala Phe Phe Trp Leu Val Ser Leu Leu Ile 
        35                  40                  45              


Ser Ser Leu Val Trp Phe Met Ala Arg Val Ile Ile Asp Asn Lys Asp 
    50                  55                  60                  


Gly Pro Thr Gln Lys Tyr Leu Leu Ile Phe Gly Ala Phe Val Ser Val 
65                  70                  75                  80  


Tyr Ile Arg Glu Met Phe Arg Phe Ala Tyr Tyr Lys Leu Leu Lys Lys 
                85                  90                  95      


Ala Ser Glu Gly Leu Lys Ser Ile Asn Pro Gly Glu Thr Ala Pro Ser 
            100                 105                 110         


Met Arg Leu Leu Ala Tyr Val Ser Gly Leu Gly Phe Gly Ile Met Ser 
        115                 120                 125             


Gly Val Phe Ser Phe Val Asn Thr Leu Ser Asp Ser Leu Gly Pro Gly 
    130                 135                 140                 


Thr Val Gly Ile His Gly Asp Ser Pro Gln Phe Phe Leu Tyr Ser Ala 
145                 150                 155                 160 


Phe Met Thr Leu Val Ile Ile Leu Leu His Val Phe Trp Gly Ile Val 
                165                 170                 175     


Phe Phe Asp Gly Cys Glu Lys Lys Lys Trp Gly Ile Leu Leu Ile Val 
            180                 185                 190         


Leu Leu Thr His Leu Leu Val Ser Ala Gln Thr Phe Ile Ser Ser Tyr 
        195                 200                 205             


Tyr Gly Ile Asn Leu Ala Ser Ala Phe Ile Ile Leu Val Leu Met Gly 
    210                 215                 220                 


Thr Trp Ala Phe Leu Ala Ala Gly Gly Ser Cys Arg Ser Leu Lys Leu 
225                 230                 235                 240 


Cys Leu Leu Cys Gln Asp Lys Asn Phe Leu Leu Tyr Asn Gln Arg Ser 
                245                 250                 255     


Arg 
    


<210>  57
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Thr Ala Ala Val Phe Phe Gly Cys Ala Phe Ile Ala Phe Gly Pro 
1               5                   10                  15      


Ala Leu Ala Leu Tyr Val Phe Thr Ile Ala Ile Glu Pro Leu Arg Ile 
            20                  25                  30          


Ile Phe Leu Ile Ala Gly Ala Phe Phe Trp Leu Val Ser Leu Leu Ile 
        35                  40                  45              


Ser Ser Leu Val Trp Phe Met Ala Arg Val Ile Ile Asp Asn Lys Asp 
    50                  55                  60                  


Gly Pro Thr Gln Lys Tyr Leu Leu Ile Phe Gly Ala Phe Val Ser Val 
65                  70                  75                  80  


Tyr Ile Gln Glu Met Phe Arg Phe Ala Tyr Tyr Lys Leu Leu Lys Lys 
                85                  90                  95      


Ala Ser Glu Gly Leu Lys Ser Ile Asn Pro Gly Glu Thr Ala Pro Ser 
            100                 105                 110         


Met Arg Leu Leu Ala Tyr Val Ser Gly Leu Gly Phe Gly Ile Met Ser 
        115                 120                 125             


Gly Val Phe Ser Phe Val Asn Thr Leu Ser Asp Ser Leu Gly Pro Gly 
    130                 135                 140                 


Thr Val Gly Ile His Gly Asp Ser Pro Gln Phe Phe Leu Tyr Ser Ala 
145                 150                 155                 160 


Phe Met Thr Leu Val Ile Ile Leu Leu His Val Phe Trp Gly Ile Val 
                165                 170                 175     


Phe Phe Asp Gly Cys Glu Lys Lys Lys Trp Gly Ile Leu Leu Ile Val 
            180                 185                 190         


Leu Leu Thr His Leu Leu Val Ser Ala Gln Thr Phe Ile Ser Ser Tyr 
        195                 200                 205             


Tyr Gly Ile Asn Leu Ala Ser Ala Phe Ile Ile Leu Val Leu Met Gly 
    210                 215                 220                 


Thr Trp Ala Phe Leu Ala Ala Gly Gly Ser Cys Arg Ser Leu Lys Leu 
225                 230                 235                 240 


Cys Leu Leu Cys Gln Asp Lys Asn Phe Leu Leu Tyr Asn Gln Arg Ser 
                245                 250                 255     


Arg 
    


<210>  58
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Thr Ala Ala Val Phe Phe Gly Cys Ala Phe Ile Ala Phe Gly Pro 
1               5                   10                  15      


Ala Leu Ala Leu Tyr Val Phe Thr Ile Ala Thr Glu Pro Leu Arg Ile 
            20                  25                  30          


Ile Phe Leu Ile Ala Gly Ala Phe Phe Trp Leu Val Ser Leu Leu Ile 
        35                  40                  45              


Ser Ser Leu Val Trp Phe Met Ala Arg Val Ile Ile Asp Asn Lys Asp 
    50                  55                  60                  


Gly Pro Thr Gln Lys Tyr Leu Leu Ile Phe Gly Ala Phe Val Ser Val 
65                  70                  75                  80  


Tyr Ile Gln Glu Met Phe Arg Phe Ala Tyr Tyr Lys Leu Leu Lys Lys 
                85                  90                  95      


Ala Ser Glu Gly Leu Lys Ser Ile Asn Pro Gly Glu Thr Ala Pro Ser 
            100                 105                 110         


Met Arg Leu Leu Ala Tyr Val Ser Gly Leu Gly Phe Gly Ile Met Ser 
        115                 120                 125             


Gly Val Phe Ser Phe Val Asn Thr Leu Ser Asp Ser Leu Gly Pro Gly 
    130                 135                 140                 


Thr Val Gly Ile His Gly Asp Ser Pro Gln Phe Phe Leu Tyr Ser Ala 
145                 150                 155                 160 


Phe Met Thr Leu Val Ile Ile Leu Leu His Val Phe Trp Gly Ile Val 
                165                 170                 175     


Phe Phe Asp Gly Cys Glu Lys Lys Lys Trp Gly Ile Leu Leu Ile Val 
            180                 185                 190         


Leu Leu Thr His Leu Leu Val Ser Ala Gln Thr Phe Ile Ser Ser Tyr 
        195                 200                 205             


Tyr Gly Ile Asn Leu Ala Ser Ala Phe Ile Ile Leu Val Leu Met Gly 
    210                 215                 220                 


Thr Trp Ala Phe Leu Ala Ala Gly Gly Ser Cys Arg Ser Leu Lys Leu 
225                 230                 235                 240 


Cys Leu Leu Cys Gln Asp Lys Asn Phe Leu Leu Tyr Asn Gln Arg Ser 
                245                 250                 255     


Arg 
    


