                         SEQUENCE LISTING

<110>  Liu, Chuanju
       Jian, Jinlong
 
<120>  PROGRANULIN (PGRN) AND ITS DERIVATIVES FOR DIAGNOSIS AND 
       TREATMENT OF LYSOSOMAL STORAGE DISEASES

<130>  1049-1-224PCT

<140>  Unassigned
<141>  2015-02-04

<150>  61/935,541
<151>  2014-02-04

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  consensus


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  X is any 5 or 6 amino acids

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  X is any 5 amino acids

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  X is any 8 amino acids

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  X is any 6 amino acids

<220>
<221>  VARIANT
<222>  (13)..(13)
<223>  X is any amino acid

<220>
<221>  VARIANT
<222>  (15)..(15)
<223>  X is any 2 amino acids

<220>
<221>  VARIANT
<222>  (20)..(20)
<223>  X is any 4 amino acids

<220>
<221>  VARIANT
<222>  (22)..(22)
<223>  X is any 5-6 amino acids

<400>  1

Cys Xaa Cys Xaa Cys Cys Xaa Cys Cys Xaa Cys Cys Xaa Asp Xaa His 
1               5                   10                  15      


Cys Cys Pro Xaa Cys Xaa Cys 
            20              


<210>  2
<211>  593
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Trp Thr Leu Val Ser Trp Val Ala Leu Thr Ala Gly Leu Val Ala 
1               5                   10                  15      


Gly Thr Arg Cys Pro Asp Gly Gln Phe Cys Pro Val Ala Cys Cys Leu 
            20                  25                  30          


Asp Pro Gly Gly Ala Ser Tyr Ser Cys Cys Arg Pro Leu Leu Asp Lys 
        35                  40                  45              


Trp Pro Thr Thr Leu Ser Arg His Leu Gly Gly Pro Cys Gln Val Asp 
    50                  55                  60                  


Ala His Cys Ser Ala Gly His Ser Cys Ile Phe Thr Val Ser Gly Thr 
65                  70                  75                  80  


Ser Ser Cys Cys Pro Phe Pro Glu Ala Val Ala Cys Gly Asp Gly His 
                85                  90                  95      


His Cys Cys Pro Arg Gly Phe His Cys Ser Ala Asp Gly Arg Ser Cys 
            100                 105                 110         


Phe Gln Arg Ser Gly Asn Asn Ser Val Gly Ala Ile Gln Cys Pro Asp 
        115                 120                 125             


Ser Gln Phe Glu Cys Pro Asp Phe Ser Thr Cys Cys Val Met Val Asp 
    130                 135                 140                 


Gly Ser Trp Gly Cys Cys Pro Met Pro Gln Ala Ser Cys Cys Glu Asp 
145                 150                 155                 160 


Arg Val His Cys Cys Pro His Gly Ala Phe Cys Asp Leu Val His Thr 
                165                 170                 175     


Arg Cys Ile Thr Pro Thr Gly Thr His Pro Leu Ala Lys Lys Leu Pro 
            180                 185                 190         


Ala Gln Arg Thr Asn Arg Ala Val Ala Leu Ser Ser Ser Val Met Cys 
        195                 200                 205             


Pro Asp Ala Arg Ser Arg Cys Pro Asp Gly Ser Thr Cys Cys Glu Leu 
    210                 215                 220                 


Pro Ser Gly Lys Tyr Gly Cys Cys Pro Met Pro Asn Ala Thr Cys Cys 
225                 230                 235                 240 


Ser Asp His Leu His Cys Cys Pro Gln Asp Thr Val Cys Asp Leu Ile 
                245                 250                 255     


Gln Ser Lys Cys Leu Ser Lys Glu Asn Ala Thr Thr Asp Leu Leu Thr 
            260                 265                 270         


Lys Leu Pro Ala His Thr Val Gly Asp Val Lys Cys Asp Met Glu Val 
        275                 280                 285             


Ser Cys Pro Asp Gly Tyr Thr Cys Cys Arg Leu Gln Ser Gly Ala Trp 
    290                 295                 300                 


Gly Cys Cys Pro Phe Thr Gln Ala Val Cys Cys Glu Asp His Ile His 
305                 310                 315                 320 


Cys Cys Pro Ala Gly Phe Thr Cys Asp Thr Gln Lys Gly Thr Cys Glu 
                325                 330                 335     


Gln Gly Pro His Gln Val Pro Trp Met Glu Lys Ala Pro Ala His Leu 
            340                 345                 350         


Ser Leu Pro Asp Pro Gln Ala Leu Lys Arg Asp Val Pro Cys Asp Asn 
        355                 360                 365             


Val Ser Ser Cys Pro Ser Ser Asp Thr Cys Cys Gln Leu Thr Ser Gly 
    370                 375                 380                 


Glu Trp Gly Cys Cys Pro Ile Pro Glu Ala Val Cys Cys Ser Asp His 
385                 390                 395                 400 


Gln His Cys Cys Pro Gln Gly Tyr Thr Cys Val Ala Glu Gly Gln Cys 
                405                 410                 415     


Gln Arg Gly Ser Glu Ile Val Ala Gly Leu Glu Lys Met Pro Ala Arg 
            420                 425                 430         


Arg Ala Ser Leu Ser His Pro Arg Asp Ile Gly Cys Asp Gln His Thr 
        435                 440                 445             


Ser Cys Pro Val Gly Gln Thr Cys Cys Pro Ser Leu Gly Gly Ser Trp 
    450                 455                 460                 


Ala Cys Cys Gln Leu Pro His Ala Val Cys Cys Glu Asp Arg Gln His 
465                 470                 475                 480 


Cys Cys Pro Ala Gly Tyr Thr Cys Asn Val Lys Ala Arg Ser Cys Glu 
                485                 490                 495     


Lys Glu Val Val Ser Ala Gln Pro Ala Thr Phe Leu Ala Arg Ser Pro 
            500                 505                 510         


His Val Gly Val Lys Asp Val Glu Cys Gly Glu Gly His Phe Cys His 
        515                 520                 525             


Asp Asn Gln Thr Cys Cys Arg Asp Asn Arg Gln Gly Trp Ala Cys Cys 
    530                 535                 540                 


Pro Tyr Arg Gln Gly Val Cys Cys Ala Asp Arg Arg His Cys Cys Pro 
545                 550                 555                 560 


Ala Gly Phe Arg Cys Ala Ala Arg Gly Thr Lys Cys Leu Arg Arg Glu 
                565                 570                 575     


Ala Pro Arg Trp Asp Ala Pro Leu Arg Asp Pro Ala Leu Arg Gln Leu 
            580                 585                 590         


Leu 
    


<210>  3
<211>  588
<212>  PRT
<213>  Mus musculus

<400>  3

Met Trp Ile Leu Val Ser Trp Leu Ala Leu Val Ala Arg Leu Val Ala 
1               5                   10                  15      


Gly Thr Gln Cys Pro Asp Gly Gln Phe Cys Pro Val Ala Cys Cys Leu 
            20                  25                  30          


Asp Gln Gly Gly Ala Asn Tyr Ser Cys Cys Asn Pro Leu Leu Asp Thr 
        35                  40                  45              


Trp Pro Ile Ile Thr Ser Arg Arg Leu Asp Gly Ser Cys Gln Ile Arg 
    50                  55                  60                  


Asp His Cys Pro Asp Gly Tyr Ser Cys Leu Leu Thr Val Ser Gly Thr 
65                  70                  75                  80  


Ser Ser Cys Cys Pro Phe Ser Glu Gly Val Ser Cys Asp Asp Gly Gln 
                85                  90                  95      


His Cys Cys Pro Arg Gly Phe His Cys Ser Ala Asp Gly Lys Ser Cys 
            100                 105                 110         


Ser Gln Ile Ser Asp Ser Leu Leu Gly Ala Val Gln Cys Pro Gly Ser 
        115                 120                 125             


Gln Phe Glu Cys Pro Asp Ser Ala Thr Cys Cys Ile Met Ile Asp Gly 
    130                 135                 140                 


Ser Trp Gly Cys Cys Pro Met Pro Gln Ala Ser Cys Cys Glu Asp Arg 
145                 150                 155                 160 


Val His Cys Cys Pro His Gly Ala Ser Cys Asp Leu Val His Thr Arg 
                165                 170                 175     


Cys Ile Ser Pro Thr Gly Thr His Pro Leu Leu Lys Lys Phe Pro Ala 
            180                 185                 190         


Gln Arg Thr Asn Arg Ala Val Ala Ser Phe Ser Val Val Cys Pro Asp 
        195                 200                 205             


Ala Lys Thr Gln Cys Pro Asp Asp Ser Thr Cys Cys Glu Leu Pro Thr 
    210                 215                 220                 


Gly Lys Tyr Gly Cys Cys Pro Met Pro Asn Ala Ile Cys Cys Ser Asp 
225                 230                 235                 240 


His Leu His Cys Cys Pro Gln Asp Thr Val Cys Asp Leu Ile Gln Ser 
                245                 250                 255     


Lys Cys Ile Ser Lys Asp Tyr Thr Thr Asp Leu Met Thr Lys Leu Pro 
            260                 265                 270         


Gly Tyr Pro Val Asn Glu Val Lys Cys Asp Leu Glu Val Ser Cys Pro 
        275                 280                 285             


Asp Gly Tyr Thr Cys Cys Arg Leu Asn Thr Gly Ala Trp Gly Cys Cys 
    290                 295                 300                 


Pro Phe Thr Lys Ala Val Cys Cys Glu Asp His Ile His Cys Cys Pro 
305                 310                 315                 320 


Ala Gly Phe Gln Cys His Thr Glu Thr Gly Thr Cys Glu Leu Gly Val 
                325                 330                 335     


Leu Gln Val Pro Trp Met Lys Lys Val Thr Ala Ser Leu Ser Leu Pro 
            340                 345                 350         


Asp Pro Gln Ile Leu Lys Asn Asp Val Pro Cys Asp Asp Phe Ser Ser 
        355                 360                 365             


Cys Pro Ser Asn Asn Thr Cys Cys Arg Leu Ser Ser Gly Asp Trp Gly 
    370                 375                 380                 


Cys Cys Pro Met Pro Glu Ala Val Cys Cys Leu Asp His Gln His Cys 
385                 390                 395                 400 


Cys Pro Gln Gly Phe Lys Cys Met Asp Glu Gly Tyr Cys Gln Lys Gly 
                405                 410                 415     


Asp Arg Met Val Ala Gly Leu Glu Lys Met Pro Val Arg Gln Thr Thr 
            420                 425                 430         


Leu Leu Gln His Gly Asp Ile Gly Cys Asp Gln His Thr Ser Cys Pro 
        435                 440                 445             


Val Gly Gln Thr Cys Cys Pro Ser Leu Lys Gly Ser Trp Ala Cys Cys 
    450                 455                 460                 


Gln Leu Pro His Ala Val Cys Cys Glu Asp Arg Gln His Cys Cys Pro 
465                 470                 475                 480 


Ala Gly Tyr Thr Cys Asn Val Lys Ala Arg Thr Cys Glu Lys Asp Ala 
                485                 490                 495     


Gly Ser Val Gln Pro Ser Met Asp Leu Thr Phe Gly Ser Lys Val Gly 
            500                 505                 510         


Asn Val Glu Cys Gly Ala Gly His Phe Cys His Asp Asn Gln Ser Cys 
        515                 520                 525             


Cys Lys Asp Ser Gln Gly Gly Trp Ala Cys Cys Pro Tyr Val Lys Gly 
    530                 535                 540                 


Val Cys Cys Arg Asp Gly Arg His Cys Cys Pro Ile Gly Phe His Cys 
545                 550                 555                 560 


Ser Ala Lys Gly Thr Lys Cys Leu Arg Lys Lys Thr Pro Arg Trp Asp 
                565                 570                 575     


Ile Leu Leu Arg Asp Pro Ala Pro Arg Pro Leu Leu 
            580                 585             


<210>  4
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  4

Pro Gln Ala Ser Cys Cys Glu Asp Arg Val His Cys Cys Pro His Gly 
1               5                   10                  15      


Ala Phe Cys Asp Leu Val His Thr Arg Cys Ile Thr Pro Thr Gly Thr 
            20                  25                  30          


His Pro Leu Ala Lys Lys Leu Pro Ala Gln Arg Thr Asn Arg Ala Val 
        35                  40                  45              


Ala Leu Ser Ser Ser Ala Ser Ser Lys Glu Asn Ala Thr Thr Asp Leu 
    50                  55                  60                  


Leu Thr Lys Leu Pro Ala His Thr Val Gly Asp Val Lys Cys Asp Met 
65                  70                  75                  80  


Glu Val Ser Cys Pro Asp Gly Tyr Thr Cys Cys Arg Leu Gln Ser Gly 
                85                  90                  95      


Ala Trp Pro Trp Cys Glu Gln Gly Pro His Gln Val Pro Trp Met Glu 
            100                 105                 110         


Lys Ala Pro Ala His Leu Ser Leu Pro Asp Pro Gln Ala Leu Lys Arg 
        115                 120                 125             


Asp Val Pro Cys Asp Asn Val Ser Ser Cys Pro Ser Ser Asp Thr Cys 
    130                 135                 140                 


Cys Gln Leu Thr Ser Gly Glu Trp Gly Cys Cys Pro Ile Pro 
145                 150                 155             


<210>  5
<211>  63
<212>  PRT
<213>  Homo sapiens

<400>  5

Ile Gln Cys Pro Asp Ser Gln Phe Glu Cys Pro Asp Phe Ser Thr Cys 
1               5                   10                  15      


Cys Val Met Val Asp Gly Ser Trp Gly Cys Cys Pro Met Pro Gln Ala 
            20                  25                  30          


Ser Cys Cys Glu Asp Arg Val His Cys Cys Pro His Gly Ala Phe Cys 
        35                  40                  45              


Asp Leu Val His Thr Arg Cys Ile Thr Pro Thr Gly Thr His Pro 
    50                  55                  60              


<210>  6
<211>  75
<212>  PRT
<213>  Homo sapiens

<400>  6

Ser Lys Glu Asn Ala Thr Thr Asp Leu Leu Thr Lys Leu Pro Ala His 
1               5                   10                  15      


Thr Val Gly Asp Val Lys Cys Asp Met Glu Val Ser Cys Pro Asp Gly 
            20                  25                  30          


Tyr Thr Cys Cys Arg Leu Gln Ser Gly Ala Trp Gly Cys Cys Pro Phe 
        35                  40                  45              


Thr Gln Ala Val Cys Cys Glu Asp His Ile His Cys Cys Pro Ala Gly 
    50                  55                  60                  


Phe Thr Cys Asp Thr Gln Lys Gly Thr Cys Glu 
65                  70                  75  


<210>  7
<211>  81
<212>  PRT
<213>  Homo sapiens

<400>  7

Gln Gly Pro His Gln Val Pro Trp Met Glu Lys Ala Pro Ala His Leu 
1               5                   10                  15      


Ser Leu Pro Asp Pro Gln Ala Leu Lys Arg Asp Val Pro Cys Asp Asn 
            20                  25                  30          


Val Ser Ser Cys Pro Ser Ser Asp Thr Cys Cys Gln Leu Thr Ser Gly 
        35                  40                  45              


Glu Trp Gly Cys Cys Pro Ile Pro Glu Ala Val Cys Cys Ser Asp His 
    50                  55                  60                  


Gln His Cys Cys Pro Gln Gly Tyr Thr Cys Val Ala Glu Gly Gln Cys 
65                  70                  75                  80  


Gln 
    


<210>  8
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  8

Pro Gln Ala Ser Cys Cys Glu Asp Arg Val His Cys Cys Pro His Gly 
1               5                   10                  15      


Ala Phe Cys Asp Leu Val His Thr Arg Cys Ile Thr Pro Thr Gly Thr 
            20                  25                  30          


His Pro Leu Ala Lys Lys Leu Pro Ala Gln Arg Thr Asn Arg Ala Val 
        35                  40                  45              


Ala Leu Ser Ser Ser Ala Ser Ser Lys Glu Asn Ala Thr Thr Asp Leu 
    50                  55                  60                  


Leu Thr Lys Leu Pro Ala His Thr Val Gly Asp Val Lys Cys Asp Met 
65                  70                  75                  80  


Glu Val Ser Cys Pro Asp Gly Tyr Thr Cys Cys Arg Leu Gln Ser Gly 
                85                  90                  95      


Ala Trp 
        


<210>  9
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  9

Ser Lys Glu Asn Ala Thr Thr Asp Leu Leu Thr Lys Leu Pro Ala His 
1               5                   10                  15      


Thr Val Gly Asp Val Lys Cys Asp Met Glu Val Ser Cys Pro Asp Gly 
            20                  25                  30          


Tyr Thr Cys Cys Arg Leu Gln Ser Gly Ala Trp Pro Trp Cys Glu Gln 
        35                  40                  45              


Gly Pro His Gln Val Pro Trp Met Glu Lys Ala Pro Ala His Leu Ser 
    50                  55                  60                  


Leu Pro Asp Pro Gln Ala Leu Lys Arg Asp Val Pro Cys Asp Asn Val 
65                  70                  75                  80  


Ser Ser Cys Pro Ser Ser Asp Thr Cys Cys Gln Leu Thr Ser Gly Glu 
                85                  90                  95      


Trp Gly Cys Cys Pro Ile Pro 
            100             


<210>  10
<211>  8980
<212>  DNA
<213>  Homo sapiens

<400>  10
cacctgccag ttaaaatctt cccagactca gctcaaggag atgctcctaa ggtggaatga       60

aatctcttct tccccacctg gagacaatct acttcctctc cctacacctg gcaactggcg      120

cacaaccttg tatcttaaat tagattcagc ctgagactgt ctcccaccaa tccctgctcc      180

ctgtcctgct gagcaccttg aggaaagggc tttggggctg tttatctttg tcctggaaac      240

catccttcaa ctcactctgg ggcctgccta gcatgtcaac cgagtttgga gaatagggca      300

gaatagggca ggacaggaca ggacaagaca gggcaggata ggataggagc gagccagctc      360

agtagctcac atttgtaatc ccagcgcctt ggggggctgc ggtaggagaa tcgctttggg      420

agcaggagtt gcaggccgca gtgagctatg atcagcttgg gcgactgagc gagaccctgt      480

ctctaaaaca aacacacaag tccgggcgcg gtggctcatg cctgtaatct tagcactttg      540

ggaggccgag gtgggcggat cacgaggtca agaaatcgag accatcctgg ccaacatggt      600

gaaaccccgt ctctactaaa aatacaaaaa ttagctgggc gtggtggtgc gcgcctgtag      660

tcccagctac tcgggaggct gaggcaggag aatcgcttga acccgggagg cagaggttgc      720

agtgagccga gatcgtgcca ctgcactcca gcctggcgac agagtgagac tccgtctcag      780

aacaaacaaa caaaaggata gaaaggcgag cacaaatatt cccaattcat aacactccct      840

cgcactgtca atgccccaga cacgcgctat catctctagc aaactccccc aggcgcctgc      900

aggatgggtt aaggaaggcg acgagcacca gctgccctgc tgaggctgtc ccgacgtcac      960

atgattctcc aatcacatga tccctagaaa tggggtgtgg ggcgagagga agcagggagg     1020

agagtgattt gagtagaaaa gaaacacagc attccaggct ggccccacct ctatattgat     1080

aagtagccaa tgggagcggg tagccctgat ccctggccaa tggaaactga ggtaggcggg     1140

tcatcgcgct ggggtctgta gtctgagcgc tacccggttg ctgctgccca aggaccgcgg     1200

agtcggacgc aggtaggaga gcggccgcgc agacctctcg cctgctcctg cccaggggcc     1260

cgccagggcc atgtgagctt gaggttcccc tggagtctca gccggagaca acagaagaac     1320

cgcttactga aactccttgg gggttctgat acactagggg gagttttatg ggaaagagga     1380

agcagtaatt gcagtgacgc cccgttagaa ggggctttct acctccccag cattccccca     1440

aagcagggac cacaccattc ttgacccagc tccacccctg tcggtaggtg ctggcttctt     1500

cccctctcct ggtggtggtg ggtggttccc gcggcggcct ggagccggag gggcgcgcga     1560

ccctgggctg ggagctccga gggcctggga acgagacctg agaccttggc ttctcgaagg     1620

tagtagggac ttgggagtgg tgactgaacc tggtctggct cctccttact tcctcttgtt     1680

gcgggtggga cgagctagct tccgcctctc ccagccactt tttcctgctc atttgcagct     1740

aggttggctc cccttttggg aatttcctct ccccttggca ctcggagttg gggggtgcca     1800

cctagtggaa gataacggag ctagggtctt gaagaggctg ctgtcccctc tggctgtttt     1860

ggcggtgtag ggtggcatga gagactgcga ctcgcctcct catccctgtt tctgtatgcg     1920

agtgcttgta ttcagtagaa gcatacacta tactccctca atttagggta aacaggaggg     1980

gccacatgca caggtaattc accagggagc cgaacactcc tgtgcagaca gactcccctt     2040

cccagcaagc catggcagcg gacagcctgc tgagaacacc caggaagcag gcggtgccag     2100

ctgcaggtgc tttgcctggg agctgtgggg ctgaggagag ggtccactgt ccaggaccag     2160

tgaacttcat ccttatctgt ccaggaggtg gcctcttggg gatgctgagt taggggaggg     2220

gcacttgagg aaagccaggt ggagcagaga ggatgtgagt gactgggtgg gtgagatttc     2280

ctgcccctcc ccccgcagtg gtatccacac ctagactcgt ggggtaactg aggcacagac     2340

agagagcaac ttctcaggcc ctcacagttg gcaattctag gattaggacc caagtgcgat     2400

tttcaggcag tccctgtacc ctgtttctgt tgtacctgtt gcaccattcc caggcactgc     2460

ccatcgtgcc actagtgata tgaacccagg tccaatacgc tctggggcca tcaaagcctg     2520

acgtcaccat gacctgatgt gtgacgtgtt ataggtgtcc cttggtatct tcacggaact     2580

ggttccagga ccccaaaatc tgtgggtgct caagcccctg agataaaatg gtgtaatatt     2640

tgcatataac ctatacatac tttaaatcat ttctagatta cttataccta atacaatgga     2700

aatgacatgt cggctgggcg tggtggctca tgcctgtaat cccaccactt tgggaggccg     2760

tggcaggtgg atcacctgag gtctggagtt tgagaccagc ctgaccaaca tggtgaaacc     2820

cccatctcta ctaaaaatac aaaaattagc caggtgtggt agcgcacacc tataatccca     2880

cctacttggg aggctgaggc aggagaattg cttgaacctg ggaggcggag ttcgcagtaa     2940

gctgagatcg cgccactgta ctacagcctg ggtgacagag caggactcca tctcaaaaaa     3000

aaaagagaaa aagaaaaaga aatgccatgt aaatagttgt gatcctgaat tgtttaggga     3060

ataataagaa agaactatct gtagatgttc agtatagatg cacccatcgt aagcctaact     3120

acattgtata actcagcaac gatgtaacat tttcaggggt ttttttgttt tgttttttga     3180

gacagaatct cagtctcact ctgtcaccca ggctggagta tgttggcgtg atctctgctc     3240

actgcaacct ccacctcctg ggctcaagcg attctcctgc ctcagcctct tgagtagctg     3300

ggattgcagg tgtgcgctac cacgcatggc taatttttgt atttttaata gagatggggt     3360

tttaccacgt tggtcaggct ggtcttgaac tcctgacctt gggatccgcc cacctgggcc     3420

tcccaaagtg ctgggattac aggcgttagc caccgcgccc aatatatttt gatccctggt     3480

tggatatgga gggctgactg tacttaacat ctctaagctt cagtttcctc ctttaaaata     3540

aaggtgtggc tgggtgtggt ggttcaagcc tgtaatccca gcacttaggg aggctgaggt     3600

gggtggatca gctgaggtca ggagttcaag accagcctga ccaatatggt gaaaccccct     3660

ctctgctaaa aatacaaaaa ttagccaggc gtggtggcga gcgcctgtag tcccagctac     3720

ttgcttgaac ttgggaggca gaggttgcag tgagctgaga tcgtgccact gaactcgagc     3780

atgggcaaca gagcaagact gtctcaaaaa aaaaaaaaaa aagggggtga gcagacgtgg     3840

tggcacgctc ccacagtccc agctacttag taggaggcca aggttggagg attgcttgat     3900

cccaggagtc tgagtccagc ctgggcaaca tggcaatacc tcatctctaa aaataaaata     3960

aaagtaaagg tattaattac tactttggat ggttgttgca aagaaatata tataaaataa     4020

tggagagtct tgtaactggc tcccaagagg ctcaacagac attactgttt ttgcttcttc     4080

attatgagtt acctctctgg ccaccccact gaactagctg ggctagctga gcctgggaga     4140

agagttgttt aggaagtgag aggctgctct ccacagagac tcaaggctca gttcctcctg     4200

gtgactcaga tgggcagccc agtgggcaca cgtggtctct ctccacatgt ggctgagttt     4260

cacttccaga atagatggag aggcaagggc agggtttagc atgcttgagg aatctcagag     4320

ggccctggtg gtgtggggga ccctcagaac acaggtgtct caagggctga cccagcttct     4380

gtgtcctttt ctctgggtga ggaggggaca ttcatgggca gatggtgacc tctggggaag     4440

gcagcccaga ctccactggc caccatattt cctttttcac aactttctca cccctgtggt     4500

ttcccatgtc atcatgtggc cgcttcccgc aaggccttag cggggtgcag gtatgaacat     4560

agtgtcaggc aaggaggcat ctggagggga accctggctt ttcctggggg gactccctcc     4620

ctgcacccta gccctgtcct ctcccatggc tactgatgcc ttcccctcac cccagaggtg     4680

gcccacatct gcacagatca gacccacaaa aatcacgtct tcctgactct cataagcctg     4740

cccagtgagg cccaggcatt aggccatgtg ctggggactc agacccacac atatacgcat     4800

gtcagcattc atgcttacag gtccgcacat gctggggcaa gtgtcacaca cggggcgctg     4860

taggaagctg actctcagcc cctgcagatt tctgcctgcc tggacaggga ggtgttgaga     4920

aggctcaggc agtcctgggc caggaccttg gcctggggct agggtactga gtgaccctag     4980

aatcaagggt ggcgtgggct taagcagttg ccagacgttc cttggtactt tgcaggcaga     5040

ccatgtggac cctggtgagc tgggtggcct taacagcagg gctggtggct ggaacgcggt     5100

gcccagatgg tcagttctgc cctgtggcct gctgcctgga ccccggagga gccagctaca     5160

gctgctgccg tccccttctg gtgagtgccc ctcagcctag gcaagagctg gcagcctggg     5220

ttttcccaaa gggtcatctt ggattggcca gaggaggacg ccaggcacaa gtctgtggtt     5280

tatcattttc cctgtctttc taggacaaat ggcccacaac actgagcagg catctgggtg     5340

gcccctgcca ggttgatgcc cactgctctg ccggccactc ctgcatcttt accgtctcag     5400

ggacttccag ttgctgcccc ttcccagagg tgagcgtgcc atcagcccag tggaggggct     5460

taggtctgca tttatgcttt tcctgcactc taccacctgc agataaaagg gccctgccaa     5520

tgcaggtttc tctgtgttcc acaggccgtg gcatgcgggg atggccatca ctgctgccca     5580

cggggcttcc actgcagtgc agacgggcga tcctgcttcc aaagatcagg tgcagctggg     5640

gtgtgggtgc agggcaggca gacgggcagc atgtggagtc tggaacccag gagcccagct     5700

ggcgggggca gccctgattc ctgcccttgt gccctcattc atgtggcatc tgtactaagc     5760

aacagccctg ctgtggacag aggggcagca ctggggatag gagggtgcgg gagaaagtgc     5820

aagactccag gtccaggcgt tgtgggggtg gggagaggtc gagctgggcc ggtctaatac     5880

caacccatgg tcagtgggtg ccccttcccc atgccatctt gctgagggag ggactggatt     5940

gtgaggaggg tgagttaggc ctgcctagga gatcactgag ccttagtgtc accctcaaac     6000

cccagtagct gggcttgcag gccctggtgc caccagctcc ttgtgtgatg ggggagtcac     6060

cttccctgag tgggctggta gtatcctggg tcatcttgtc cacaggtaac aactccgtgg     6120

gtgccatcca gtgccctgat agtcagttcg aatgcccgga cttctccacg tgctgtgtta     6180

tggtcgatgg ctcctggggg tgctgcccca tgccccaggt acaaatctgg gggagatggg     6240

ggtatgtgga gggaagtggg ggcagagttg ggggccaggg gcagggggtg aagacggagt     6300

caggaccatt ttttctcagg cttcctgctg tgaagacagg gtgcactgct gtccgcacgg     6360

tgccttctgc gacctggttc acacccgctg catcacaccc acgggcaccc accccctggc     6420

aaagaagctc cctgcccaga ggactaacag ggcaggtgag gaggtgggag agcatcaggc     6480

caggggctgg ggcggggcct cattgactcc aagtgtagga aaaagtttcc tccatcctgg     6540

ctgcccctca cgtttgctcc tcttccagtg gccttgtcca gctcggtcat gtgtccggac     6600

gcacggtccc ggtgccctga tggttctacc tgctgtgagc tgcccagtgg gaagtatggc     6660

tgctgcccaa tgcccaacgt gagtgagggg ctggagccag cttggctgtg tgcccccagc     6720

cacctggccc tgacacgcac cttacagggg ctctgtggca tggggctggc tggctgcttg     6780

ctgggagcct ggctgatgca gggttcatgc taccccctag tgggggattg gggcagtgcc     6840

agccatcagc ctggctgctc cctgtgtgct actgagcctg gaagtgacaa agacccaccc     6900

ctgtccccac tcaggccacc tgctgctccg atcacctgca ctgctgcccc caagacactg     6960

tgtgtgacct gatccagagt aagtgcctct ccaaggagaa cgctaccacg gacctcctca     7020

ctaagctgcc tgcgcacaca ggtaccagag gcagggtgca gatacagggg tggggccccc     7080

tttcctccct tttaggcctg gccttaggat cactgcaagg tggtgtaagc ggtaccctcc     7140

atcttcaaca cctggttcca gctgtggagc cggcaaaggg ttgatacccc tgagggtccc     7200

cagtgccact tctgacctgt cctctctgct tccctcacag tgggggatgt gaaatgtgac     7260

atggaggtga gctgcccaga tggctatacc tgctgccgtc tacagtcggg ggcctggggc     7320

tgctgccctt ttacccaggt acccaggggt ggcgggtggg tgggctgagc acagtgtggc     7380

aggcagccgg gccccagtgc ccacctgccc ttcttcatct gccctaggct gtgtgctgtg     7440

aggaccacat acactgctgt cccgcggggt ttacgtgtga cacgcagaag ggtacctgtg     7500

aacaggggcc ccaccaggtg ccctggatgg agaaggcccc agctcacctc agcctgccag     7560

acccacaagc cttgaagaga gatgtcccct gtgataatgt cagcagctgt ccctcctccg     7620

atacctgctg ccaactcacg tctggggagt ggggctgctg tccaatccca gaggtatatg     7680

ggaggggaca gcatcttggc ctgggcaggt gggtggccaa gctcctattg ctttctgccc     7740

tccgcatagc ccataggtga tacccagctc tgacagattc gtccccagct ggaggtgctg     7800

taagcaggag aggcgggctg gagtaggtag gggctcggca ctgcgcccca catagtggct     7860

acctacaacg ccctttcctg cccacccccc aggctgtctg ctgctcggac caccagcact     7920

gctgccccca gggctacacg tgtgtagctg aggggcagtg tcagcgagga agcgagatcg     7980

tggctggact ggagaagatg cctgcccgcc gggcttcctt atcccacccc agagacatcg     8040

gctgtgacca gcacaccagc tgcccggtgg ggcagacctg ctgcccgagc ctgggtggga     8100

gctgggcctg ctgccagttg ccccatgtga gtgcctccct gcctgcccct ggatagggga     8160

gctaagccca gtgaggggac aggaacataa tgccattctg tgctcccttc cccgccaggc     8220

tgtgtgctgc gaggatcgcc agcactgctg cccggctggc tacacctgca acgtgaaggc     8280

tcgatcctgc gagaaggaag tggtctctgc ccagcctgcc accttcctgg cccgtagccc     8340

tcacgtgggt gtgaaggacg tggagtgtgg ggaaggacac ttctgccatg ataaccagac     8400

ctgctgccga gacaaccgac agggctgggc ctgctgtccc taccgccagg tcagtgccaa     8460

cccccatcct ggggctgggt atggccaggg accaggtccc acctcgtcca accctctcgc     8520

ccccctctga ccatccaggg cgtctgttgt gctgatcggc gccactgctg tcctgctggc     8580

ttccgctgcg cagccagggg taccaagtgt ttgcgcaggg aggccccgcg ctgggacgcc     8640

cctttgaggg acccagcctt gagacagctg ctgtgaggga cagtactgaa gactctgcag     8700

ccctcgggac cccactcgga gggtgccctc tgctcaggcc tccctagcac ctccccctaa     8760

ccaaattctc cctggacccc attctgagct ccccatcacc atgggaggtg gggcctcaat     8820

ctaaggcctt ccctgtcaga agggggttgt ggcaaaagcc acattacaag ctgccatccc     8880

ctccccgttt cagtggaccc tgtggccagg tgcttttccc tatccacagg ggtgtttgtg     8940

tgtgtgcgcg tgtgcgtttc aataaagttt gtacactttc                           8980


<210>  11
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  forward primer

<400>  11
tgtcctggaa accatccttc                                                   20


<210>  12
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  reverse primer

<400>  12
ctcccaaagc gattctccta                                                   20


<210>  13
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Taqman tag sequence


<220>
<221>  variant
<222>  (14)..(14)
<223>  n is a C or T

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  n is a, c, g, or t

<400>  13
tcagtagctc acanttgtaa                                                   20


<210>  14
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  forward primer

<400>  14
ccttccctga gtgggctggt a                                                 21


<210>  15
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  reverse primer

<400>  15
agtgcaccct gtcttcacag c                                                 21


<210>  16
<211>  51
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Taqman tag sequence


<220>
<221>  variant
<222>  (26)..(26)
<223>  n is an A or G

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  n is a, c, g, or t

<400>  16
aggtacaaat ctgggggaga tggggntatg tggagggaag tgggggcaga g                51


<210>  17
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  forward primer

<400>  17
ctgtcctctc ccatggctac                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  reverse primer

<400>  18
gcggacctgt aagcatgaat                                                   20


<210>  19
<211>  16
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Taqman tag sequence


<220>
<221>  variant
<222>  (9)..(9)
<223>  n is a G or C

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  n is a, c, g, or t

<400>  19
aggaagacnt gatttt                                                       16


<210>  20
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  forward primer

<400>  20
ccaggggtac caagtgtttg                                                   20


<210>  21
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  reverse primer

<400>  21
cacagggtcc actgaaacg                                                    19


<210>  22
<211>  51
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Taqman tag sequence


<220>
<221>  variant
<222>  (26)..(26)
<223>  n is a Cor T

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  n is a, c, g, or t

<400>  22
tctgctcagg cctccctagc acctcnccct aaccaaattc tccctggacc c                51


<210>  23
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  forward primer

<400>  23
ggtggtgtaa gcggtaccct                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  reverse primer

<400>  24
acctgcccag gccaagatgc                                                   20


