                         SEQUENCE LISTING

<110>  Gavish-Galilee Bio Applications, Ltd.
       Katz, Chen
       Pitcovski, Jacob
       Aizenshtein, Elina
       Caroline Noach
       Avner Finger

 
<120>  A genetic system for generating conditionally inactivated or 
       attenuated bacteria 

<130>  GAVISH-056 PCT

<150>  61/936,017
<151>  2014-02-05

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  781
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid

<400>  1
agatctccaa aatatattca cgttgaccat tgtttatcgt caaaacaccc atacagagct       60

aagggataat gcgtagcgcc cggcgcttga ggctttctgc ctcatgacgt gaaggtggtt      120

tgttgccgtg ttgtgtggca gaaagaagat agccccgtag taagttaatt ttcattaacc      180

accacgaggc atccctatgt ctagtccaca tccggacagc ctcttaccgc gctttgcgca      240

aggagaagaa ggccatgaaa ctaccacgaa gttcccttgt ctggtgtgtg ttgatcgtgt      300

gtctcacact gttgatattc acttatctga cacgaaaatc gctgtgcgag attcgttaca      360

gagacggaca cagggaggtg gcggctttca tggcttacga atccggtaag tagcaacctg      420

gaggcgggcg caggcccgcc ttttcagggc ttgaggcttt ctgcctcatg acgtgaaggt      480

ggtttgttgc cgtgttgtgt ggcagaaaga agatagcccc gtagtaagtt aattttcatt      540

aaccaccacg aggcatccct atgtctagtc cactgtgggc attttacggg aaggttacat      600

tactgtaaac atgattaaat tcctgttact tggatttggc tgccaggtca catatgttgc      660

aaaacatatc aggttgattt taagaagctg ttgcaaaagg gcgttataac aaaaggggag      720

tgctgaagga gtctgggcgg gcaattggta taacctcagt gaaagtaaac aataacttaa      780

c                                                                      781


<210>  2
<211>  660
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid

<400>  2
gggctaccgg cgaaccagca gcccctttat aaaggcgctt cagtagtcag accagcatca       60

gtcctgaaaa ggcgggcctg cgcccgcctc caggttgcta cttaccggat tcgtaagcca      120

tgaaagccgc cacctccctg tgtccgtctc tgtaacgaat ctcgcacagc gattttcgtg      180

tcagataagt gaatatcaac agtgtgagac acacgatcaa cacacaccag acaagggaac      240

ttcgtggtag tttcatggcc ttcttctcct tgcgcaaagc gcggtaagag gctgtccgga      300

tgtggactag acatagggat gcctcgtggt ggttaatgaa aattaactta ctacggggct      360

atcttctttc tgccacacaa cacggcaaca aaccaccttc acgtcatgag gcagaaagcc      420

tcaagcgccg ggaaggagaa tccaataata ttcgtagcat ctatggcgat ataatacctg      480

ctgacaacta aaccaacgat aaaccagact ttacccattg ctgaatgcac gggtagtgga      540

ctagacatag ggatgcctcg tggtggttaa tgaaaattaa cttactacgg ggctatcttc      600

tttctgccac acaacacggc aacaaaccac cttcacgtca tgaggcagaa agcctcaagc      660


<210>  3
<211>  1791
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid

<400>  3
catgggtgag tttattcttg acagtgcggc cgggggctga tatcatagca gacccggcgc       60

ttgaggcttt ctgcctcatg acgtgaaggt ggtttgttgc cgtgttgtgt ggcagaaaga      120

agatagcccc gtagtaagtt aattttcatt aaccaccacg aggcatccct atgtctagtc      180

cacatccgga cagcctctta ccgcgctttg cgcaaggaga agaaggccat gaaactacca      240

cgaagttccc ttgtctggtg tgtgttgatc gtgtgtctca cactgttgat attcacttat      300

ctgacacgaa aatcgctgtg cgagattcgt tacagagacg gacacaggga ggtggcggct      360

ttcatggctt acgaatccgg taagtagcaa cctggaggcg ggcgcaggcc cgccttttca      420

gggcagggat tctgcaaacc ctatgctact ccgtcaagcc gtcaattgtc tgattcgtta      480

ccaattatga caacttgacg gctacatcat tcactttttc ttcacaaccg gcacggaact      540

cgctcgggct ggccccggtg cattttttaa atacccgcga gaaatagagt tgatcgtcaa      600

aaccaacatt gcgaccgacg gtggcgatag gcatccgggt ggtgctcaaa agcagcttcg      660

cctggctgat acgttggtcc tcgcgccagc ttaagacgct aatccctaac tgctggcgga      720

aaagatgtga cagacgcgac ggcgacaagc aaacatgctg tgcgacgctg gcgatatcaa      780

aattgctgtc tgccaggtga tcgctgatgt actgacaagc ctcgcgtacc cgattatcca      840

tcggtggatg gagcgactcg ttaatcgctt ccatgcgccg cagtaacaat tgctcaagca      900

gatttatcgc cagcagctcc gaatagcgcc cttccccttg cccggcgtta atgatttgcc      960

caaacaggtc gctgaaatgc ggctggtgcg cttcatccgg gcgaaagaac cccgtattgg     1020

caaatattga cggccagtta agccattcat gccagtaggc gcgcggacga aagtaaaccc     1080

actggtgata ccattcgcga gcctccggat gacgaccgta gtgatgaatc tctcctggcg     1140

ggaacagcaa aatatcaccc ggtcggcaaa caaattctcg tccctgattt ttcaccaccc     1200

cctgaccgcg aatggtgaga ttgagaatat aacctttcat tcccagcggt cggtcgataa     1260

aaaaatcgag ataaccgttg gcctcaatcg gcgttaaacc cgccaccaga tgggcattaa     1320

acgagtatcc cggcagcagg ggatcatttt gcgcttcagc catacttttc atactcccgc     1380

cattcagaga agaaaccaat tgtccatatt gcatcagaca ttgccgtcac tgcgtctttt     1440

actggctctt ctcgctaacc aaaccggtaa ccccgcttat taaaagcatt ctgtaacaaa     1500

gcgggaccaa agccatgaca aaaacgcgta acaaaagtgt ctataatcac ggcagaaaag     1560

tccacattga ttatttgcac ggcgtcacac tttgctatgc catagcattt ttatccataa     1620

gattagcgga tcctacctga cgctttttat cgcaactctc tacgatgtgg actagacata     1680

gggatgcctc gtggtggtta atgaaaatta acttactacg gggctatctt ctttctgcca     1740

cacaacacgg caacaaacca ccttcacgtc atgaggcaga aagcctcaag c              1791


<210>  4
<211>  1094
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid

<400>  4
agatctccaa aatatattca cgttgaccat tgtttatcgt caaaacaccc atacagagct       60

aagggataat gcgtagcgtt cacgtaactg gaggaatgaa atgaaggaga gtaaacggaa      120

taagccaggg aaggcgacag gtaaaggtaa accagttggt gataaatggc tggatgatgc      180

aggtaaagat tcaggagcgc caattccaga tcgcattgct gataagttgc gtgataaaga      240

atttaaaaac tttgacgatt tccggaagaa attctgggaa gaagtgtcaa aagatcccga      300

tcttagtaag caatttaaag gcagtaataa gacgaacatt caaaagggaa aagcaccttt      360

tgcaaggaag aaagaccaag taggtggtag ggaacgcttt gaattacatc atgataaacc      420

aatcagtcag gatggtggtg tctatgatat gaataatatc agagtgacca cacctaagcg      480

acatattgat attcatcggg gtaagtaaca acctggaggc gggcgcaggc ccgccttttg      540

cttgaggctt tctgcctcat gacgtgaagg tggtttgttg ccgtcagccc tgtttaaatc      600

ctgacttacc gttagcagct cgccattctt taatttcctt gacaatccct tcaggactat      660

cttccctgtc atcgcgagga taataaatca gatctgaacc atctgggtgc tcagttaatc      720

gctcaaactc tctcactaat ttattgtcat cctcttcagt agcaccttca gctctacata      780

ttttttttac aaactccaga aattcagcct cggtataatc actaatacta tgtttcagtt      840

ccatttaacg acctcaattc cacgggatct ggtggcgttt aaagtgtgtg ggcattttac      900

gggaaggtta cattactgta aacatgatta aattcctgtt acttggattt ggctgccagg      960

tcacatatgt tgcaaaacat atcaggttga ttttaagaag ctgttgcaaa agggcgttat     1020

aacaaaaggg gagtgctgaa ggagtctggg cgggcaattg gtataacctc agtgatagta     1080

aacaataact taac                                                       1094


<210>  5
<211>  927
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid

<400>  5
aaaggcgggc ctgcgcccgc ctccaggttg ttacttaccc cgatgaatat caatatgtcg       60

cttaggtgtg gtcactctga tattattcat atcatagaca ccaccatcct gactgattgg      120

tttatcatga tgtaattcaa agcgttccct accacctact tggtctttct tccttgcaaa      180

aggtgctttt cccttttgaa tgttcgtctt attactgcct ttaaattgct tactaagatc      240

gggatctttt gacacttctt cccagaattt cttccggaaa tcgtcaaagt ttttaaattc      300

tttatcacgc aacttatcag caatgcgatc tggaattggc gctcctgaat ctttacctgc      360

atcatccagc catttatcac caactggttt acctttacct gtcgccttcc ctggcttatt      420

ccgtttactc tccttcatat aacctccggt aagtgaaaaa agcgccgcaa ataataagga      480

gaatccaata atattcgaag cttctatggc gatataatac ctgctgacaa ctaaaccaac      540

gataaaccag actttaccca ttgctgaatg cacgggtaac gtcaggctca aacaactaaa      600

caacacgtta caggacaaca ggatggaact gaaacatagt attagtgatt ataccgaggc      660

tgaatttctg gagtttgtaa aaaaaatatg tagagctgaa ggtgctactg aagaggatga      720

caataaatta gtgagagagt ttgagcgatt aactgagcac ccagatggtt cagatctgat      780

ttattatcct cgcgatgaca gggaagatag tcctgaaggg attgtcaagg aaattaaaga      840

atggcgagct gctaacggta agtcaggatt taaacagggc tgacggcaac aaaccacctt      900

cacgtcatga ggcagaaagc ctcaagc                                          927


<210>  6
<211>  2142
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid

<400>  6
atgggtgagt ttattcttga cagtgcggcc gggggctgat atcatagcag attttatgta       60

cagtattaat catgtaatta attgttttaa cgcttaaaag agggaatttt tatgaaggag      120

agtaaacgga ataagccagg gaaggcgaca ggtaaaggta aaccagttgg tgataaatgg      180

ctggatgatg caggtaaaga ttcaggagcg ccaattccag atcgcattgc tgataagttg      240

cgtgataaag aatttaaaaa ctttgacgat ttccggaaga aattctggga agaagtgtca      300

aaagatcccg atcttagtaa gcaatttaaa ggcagtaata agacgaacat tcaaaaggga      360

aaagcacctt ttgcaaggaa gaaagaccaa gtaggtggta gggaacgctt tgaattacat      420

catgataaac caatcagtca ggatggtggt gtctatgata tgaataatat cagagtgacc      480

acacctaagc gacatattga tattcatcgg ggtaagtaac aacctggagg cgggcgcagg      540

cccgcctttt gcagggattc tgcaaaccct atgctactcc gtcaagccgt caattgtctg      600

attcgttacc aattatgaca acttgacggc tacatcattc actttttctt cacaaccggc      660

acggaactcg ctcgggctgg ccccggtgca ttttttaaat acccgcgaga aatagagttg      720

atcgtcaaaa ccaacattgc gaccgacggt ggcgataggc atccgggtgg tgctcaaaag      780

cagcttcgcc tggctgatac gttggtcctc gcgccagctt aagacgctaa tccctaactg      840

ctggcggaaa agatgtgaca gacgcgacgg cgacaagcaa acatgctgtg cgacgctggc      900

gatatcaaaa ttgctgtctg ccaggtgatc gctgatgtac tgacaagcct cgcgtacccg      960

attatccatc ggtggatgga gcgactcgtt aatcgcttcc atgcgccgca gtaacaattg     1020

ctcaagcaga tttatcgcca gcagctccga atagcgccct tccccttgcc cggcgttaat     1080

gatttgccca aacaggtcgc tgaaatgcgg ctggtgcgct tcatccgggc gaaagaaccc     1140

cgtattggca aatattgacg gccagttaag ccattcatgc cagtaggcgc gcggacgaaa     1200

gtaaacccac tggtgatacc attcgcgagc ctccggatga cgaccgtagt gatgaatctc     1260

tcctggcggg aacagcaaaa tatcacccgg tcggcaaaca aattctcgtc cctgattttt     1320

caccaccccc tgaccgcgaa tggtgagatt gagaatataa cctttcattc ccagcggtcg     1380

gtcgataaaa aaatcgagat aaccgttggc ctcaatcggc gttaaacccg ccaccagatg     1440

ggcattaaac gagtatcccg gcagcagggg atcattttgc gcttcagcca tacttttcat     1500

actcccgcca ttcagagaag aaaccaattg tccatattgc atcagacatt gccgtcactg     1560

cgtcttttac tggctcttct cgctaaccaa accggtaacc ccgcttatta aaagcattct     1620

gtaacaaagc gggaccaaag ccatgacaaa aacgcgtaac aaaagtgtct ataatcacgg     1680

cagaaaagtc cacattgatt atttgcacgg cgtcacactt tgctatgcca tagcattttt     1740

atccataaga ttagcggatc ctacctgacg ctttttatcg caactctcta ctgtttctcc     1800

atacccgttt ttttgggcta gcaggaggaa ttcaccatgg aactgaaaca tagtattagt     1860

gattataccg aggctgaatt tctggagttt gtaaaaaaaa tatgtagagc tgaaggtgct     1920

actgaagagg atgacaataa attagtgaga gagtttgagc gattaactga gcacccagat     1980

ggttcagatc tgatttatta tcctcgcgat gacagggaag atagtcctga agggattgtc     2040

aaggaaatta aagaatggcg agctgctaac ggtaagtcag gatttaaaca gggctgacgg     2100

caacaaacca ccttcacgtc atgaggcaga aagcctcaag cc                        2142


<210>  7
<211>  1760
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid

<400>  7
agatctccaa aatatattca cgttgaccat tgtttatcgt caaaacaccc atacagagct       60

aagggataat gcgtagcgtt cacgtaactg gaggaatgaa atgaaggaga gtaaacggaa      120

taagccaggg aaggcgacag gtaaaggtaa accagttggt gataaatggc tggatgatgc      180

aggtaaagat tcaggagcgc caattccaga tcgcattgct gataagttgc gtgataaaga      240

atttaaaaac tttgacgatt tccggaagaa attctgggaa gaagtgtcaa aagatcccga      300

tcttagtaag caatttaaag gcagtaataa gacgaacatt caaaagggaa aagcaccttt      360

tgcaaggaag aaagaccaag taggtggtag ggaacgcttt gaattacatc atgataaacc      420

aatcagtcag gatggtggtg tctatgatat gaataatatc agagtgacca cacctaagcg      480

acatattgat attcatcggg gtaagtaaca acctggaggc gggcgcaggc ccgccttttg      540

cttgaggctt tctgcctcat gacgtgaagg tggtttgttg ccgtcagccc tgtttaaatc      600

ctgacttacc gttagcagct cgccattctt taatttcctt gacaatccct tcaggactat      660

cttccctgtc atcgcgagga taataaatca gatctgaacc atctgggtgc tcagttaatc      720

gctcaaactc tctcactaat ttattgtcat cctcttcagt agcaccttca gctctacata      780

ttttttttac aaactccaga aattcagcct cggtataatc actaatacta tgtttcagtt      840

ccatttaacg acctcaattc cacgggatct ggtggcgttt aaagtgtgtg ggcattttac      900

gggaaggtta cattactgta aacatgatta aattcctgtt acttggattt ggctgccagg      960

tcacatatgt tgcaaaacat atcaggttga ttttaagaag ctgttgcaaa agggcgttat     1020

aacaaaaggg gagtgctgaa ggagtctggg cgggcaattg gtataacctc agtgatagta     1080

aacaataact taacgtcgac gggctaccgg cgaaccagca gcccctttat aaaggcgctt     1140

cagtagtcag accagcatca gtcctgaaaa ggcgggcctg cgcccgcctc caggttgcta     1200

cttaccggat tcgtaagcca tgaaagccgc cacctccctg tgtccgtctc tgtaacgaat     1260

ctcgcacagc gattttcgtg tcagataagt gaatatcaac agtgtgagac acacgatcaa     1320

cacacaccag acaagggaac ttcgtggtag tttcatggcc ttcttctcct tgcgcaaagc     1380

gcggtaagag gctgtccgga tgtggactag acatagggat gcctcgtggt ggttaatgaa     1440

aattaactta ctacggggct atcttctttc tgccacacaa cacggcaaca aaccaccttc     1500

acgtcatgag gcagaaagcc tcaagcgccg ggaaggagaa tccaataata ttcgtagcat     1560

ctatggcgat ataatacctg ctgacaacta aaccaacgat aaaccagact ttacccattg     1620

ctgaatgcac gggtagtgga ctagacatag ggatgcctcg tggtggttaa tgaaaattaa     1680

cttactacgg ggctatcttc tttctgccac acaacacggc aacaaaccac cttcacgtca     1740

tgaggcagaa agcctcaagc                                                 1760


<210>  8
<211>  775
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid

<400>  8
attaatattt cttatcaaaa tatctaaaag gaattaatgt ctatgataat aataatttta       60

ctttttacta tgcgttggct ttgcttttgc ttgctctgaa cattctcata ccgattttaa      120

agatcttaat aaaaccgagt ataattctca atcccggcgc ttgaggcttt ctgcctcatg      180

acgtgaaggt ggtttgttgc cgtgttgtgt ggcagaaaga agatagcccc gtagtaagtt      240

aattttcatt aaccaccacg aggcatccct atgtctagtc cacatccgga cagcctctta      300

ccgcgctttg cgcaaggaga agaaggccat gaaactacca cgaagttccc ttgtctggtg      360

tgtgttgatc gtgtgtctca cactgttgat attcacttat ctgacacgaa aatcgctgtg      420

cgagattcgt tacagagacg gacacaggga ggtggcggct ttcatggctt acgaatccgg      480

taagtagcaa cctggaggcg ggcgcaggcc cgccttttca gggcttgagg ctttctgcct      540

catgacgtga aggtggtttg ttgccgtgtt gtgtggcaga aagaagatag ccccgtagta      600

agttaatttt cattaaccac cacgaggcat ccctatgtct agtccacttt gagtggtttt      660

ttgattatca aaaagtattg tattataaaa aaatattttt gtcgtattaa taatttttat      720

catttatgaa aatgtatatc aaaataaatt tcacaaaaat taagctttgc taaat           775


<210>  9
<211>  1038
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid

<400>  9
attaatattt cttatcaaaa tatctaaaag gaattaatgt ctatgataat aataatttta       60

ctttttacta tgcgttggct ttgcttttgc ttgctctgaa cattctcata ccgattttaa      120

agatccttaa taaaaccgag tataattctc aattaaagga taaaatatga aggagagtaa      180

acggaataag ccagggaagg cgacaggtaa aggtaaacca gttggtgata aatggctgga      240

tgatgcaggt aaagattcag gagcgccaat tccagatcgc attgctgata agttgcgtga      300

taaagaattt aaaaactttg acgatttccg gaagaaattc tgggaagaag tgtcaaaaga      360

tcccgatctt agtaagcaat ttaaaggcag taataagacg aacattcaaa agggaaaagc      420

accttttgca aggaagaaag accaagtagg tggtagggaa cgctttgaat tacatcatga      480

taaaccaatc agtcaggatg gtggtgtcta tgatatgaat aatatcagag tgaccacacc      540

taagcgacat attgatattc atcggggtaa gtaacaacct ggaggcgggc gcaggcccgc      600

cttttgcttg aggctttctg cctcatgacg tgaaggtggt ttgttgccgt cagccctgtt      660

taaatcctga cttaccgtta gcagctcgcc attctttaat ttccttgaca atcccttcag      720

gactatcttc cctgtcatcg cgaggataat aaatcagatc tgaaccatct gggtgctcag      780

ttaatcgctc aaactctctc actaatttat tgtcatcctc ttcagtagca ccttcagctc      840

tacatatttt ttttacaaac tccagaaatt cagcctcggt ataatcacta atactatgtt      900

tcagttccat tttgactcct tttttgatta tcaaaaagta ttgtattata aaaaaatatt      960

tttgtcgtat taataatttt tatcatttat gaaaatgtat atcaaaataa atttcacaaa     1020

aattaagctt tgctaaat                                                   1038


