                         SEQUENCE LISTING



<110>  YEDA RESEARCH AND DEVELOPMENT CO. LTD.

       SHACHAR, Idit

       BINSKY, Inbal

       MAROM, Ayelet

 

<120>  ANTI CD84 ANTIBODIES, COMPOSITIONS COMPRISING SAME AND USES 

       THEREOF



<130>  60794



<150>  US 61/936,361

<151>  2014-02-06



<160>  29    



<170>  PatentIn version 3.5



<210>  1

<211>  5

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  B4-Heavy Chain CDR1



<400>  1



Ser Tyr Trp Met Gln 

1               5   





<210>  2

<211>  17

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  B4-Heavy Chain CDR2



<400>  2



Ala Ile Tyr Pro Gly Asp Gly Asp Thr Arg Tyr Thr Gln Lys Phe Lys 

1               5                   10                  15      





Gly 

    





<210>  3

<211>  10

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  B4-Heavy Chain CDR3



<400>  3



Leu Leu Arg Thr Tyr Trp Tyr Phe Asp Val 

1               5                   10  





<210>  4

<211>  11

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  B4-Light Chain CDR1



<400>  4



Lys Ala Ser Gln Asp Val Gly Thr Ala Val Ala 

1               5                   10      





<210>  5

<211>  7

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  B4-Light Chain CDR2



<400>  5



Trp Ala Ser Thr Arg His Thr 

1               5           





<210>  6

<211>  9

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  B4-Light Chain CDR3



<400>  6



Gln Gln Tyr Ser Ser Tyr Pro Tyr Thr 

1               5                   





<210>  7

<211>  5

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  B1-Heavy Chain CDR1



<400>  7



Ser Phe Gly Met His 

1               5   





<210>  8

<211>  17

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  B1-Heavy Chain CDR2



<400>  8



Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Thr Val Lys 

1               5                   10                  15      





Gly 

    





<210>  9

<211>  10

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  B1-Heavy Chain CDR3



<400>  9



Trp Gly Trp Thr Gly Thr Gly Leu Asp Tyr 

1               5                   10  





<210>  10

<211>  12

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  B1-Light Chain CDR1



<400>  10



Ser Val Ser Ser Ser Ile Ser Ser Ser Asn Leu His 

1               5                   10          





<210>  11

<211>  8

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  B1-Light Chain CDR2



<400>  11



Tyr Gly Thr Ser Asn Leu Ala Ser 

1               5               





<210>  12

<211>  10

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  B1-Light Chain CDR3



<400>  12



Gln Gln Trp Ser Ser Tyr Pro Phe Thr Phe 

1               5                   10  





<210>  13

<211>  1067

<212>  DNA

<213>  Homo sapiens



<400>  13

cggctcaagt gaactgactc tgctagaaca gtgccgtgct tttccacaga aggttagacc       60



ctgaaagaga tggctcagca ccacctatgg atcttgctcc tttgcctgca aacctggccg      120



gaagcagctg gaaaagactc agaaatcttc acagtgaatg ggattctggg agagtcagtc      180



actttccctg taaatatcca agaaccacgg caagttaaaa tcattgcttg gacttctaaa      240



acatctgttg cttatgtaac accaggagac tcagaaacag cacccgtagt tactgtgacc      300



cacagaaatt attatgaacg gatacatgcc ttaggtccga actacaatct ggtcattagc      360



gatctgagga tggaagacgc aggagactac aaagcagaca taaatacaca ggctgatccc      420



tacaccacca ccaagcgcta caacctgcaa atctatcgtc ggcttgggaa accaaaaatt      480



acacagagtt taatggcatc tgtgaacagc acctgtaatg tcacactgac atgctctgta      540



gagaaagaag aaaagaatgt gacatacaat tggagtcccc tgggagaaga gggtaatgtc      600



cttcaaatct tccagactcc tgaggaccaa gagctgactt acacgtgtac agcccagaac      660



cctgtcagca acaattctga ctccatctct gcccggcagc tctgtgcaga catcgcaatg      720



ggcttccgta ctcaccacac cgggttgctg agcgtgctgg ctatgttctt tctgcttgtt      780



ctcattctgt cttcagtgtt tttgttccgt ttgttcaaga gaagacaaga tgctgcctca      840



aagaaaacca tatacacata tatcatggct tcaaggaaca cccagccagc agagtccaga      900



atctatgatg aaatcctgca gtccaaggtg cttccctcca aggaagagcc agtgaacaca      960



gtttattccg aagtgcagtt tgctgataag atggggaaag ccagcacaca ggacagtaaa     1020



cctcctggga cttcaagcta tgaaattgtg atctaggctg ctgggct                   1067





<210>  14

<211>  328

<212>  PRT

<213>  Homo sapiens



<400>  14



Met Ala Gln His His Leu Trp Ile Leu Leu Leu Cys Leu Gln Thr Trp 

1               5                   10                  15      





Pro Glu Ala Ala Gly Lys Asp Ser Glu Ile Phe Thr Val Asn Gly Ile 

            20                  25                  30          





Leu Gly Glu Ser Val Thr Phe Pro Val Asn Ile Gln Glu Pro Arg Gln 

        35                  40                  45              





Val Lys Ile Ile Ala Trp Thr Ser Lys Thr Ser Val Ala Tyr Val Thr 

    50                  55                  60                  





Pro Gly Asp Ser Glu Thr Ala Pro Val Val Thr Val Thr His Arg Asn 

65                  70                  75                  80  





Tyr Tyr Glu Arg Ile His Ala Leu Gly Pro Asn Tyr Asn Leu Val Ile 

                85                  90                  95      





Ser Asp Leu Arg Met Glu Asp Ala Gly Asp Tyr Lys Ala Asp Ile Asn 

            100                 105                 110         





Thr Gln Ala Asp Pro Tyr Thr Thr Thr Lys Arg Tyr Asn Leu Gln Ile 

        115                 120                 125             





Tyr Arg Arg Leu Gly Lys Pro Lys Ile Thr Gln Ser Leu Met Ala Ser 

    130                 135                 140                 





Val Asn Ser Thr Cys Asn Val Thr Leu Thr Cys Ser Val Glu Lys Glu 

145                 150                 155                 160 





Glu Lys Asn Val Thr Tyr Asn Trp Ser Pro Leu Gly Glu Glu Gly Asn 

                165                 170                 175     





Val Leu Gln Ile Phe Gln Thr Pro Glu Asp Gln Glu Leu Thr Tyr Thr 

            180                 185                 190         





Cys Thr Ala Gln Asn Pro Val Ser Asn Asn Ser Asp Ser Ile Ser Ala 

        195                 200                 205             





Arg Gln Leu Cys Ala Asp Ile Ala Met Gly Phe Arg Thr His His Thr 

    210                 215                 220                 





Gly Leu Leu Ser Val Leu Ala Met Phe Phe Leu Leu Val Leu Ile Leu 

225                 230                 235                 240 





Ser Ser Val Phe Leu Phe Arg Leu Phe Lys Arg Arg Gln Asp Ala Ala 

                245                 250                 255     





Ser Lys Lys Thr Ile Tyr Thr Tyr Ile Met Ala Ser Arg Asn Thr Gln 

            260                 265                 270         





Pro Ala Glu Ser Arg Ile Tyr Asp Glu Ile Leu Gln Ser Lys Val Leu 

        275                 280                 285             





Pro Ser Lys Glu Glu Pro Val Asn Thr Val Tyr Ser Glu Val Gln Phe 

    290                 295                 300                 





Ala Asp Lys Met Gly Lys Ala Ser Thr Gln Asp Ser Lys Pro Pro Gly 

305                 310                 315                 320 





Thr Ser Ser Tyr Glu Ile Val Ile 

                325             





<210>  15

<211>  239

<212>  PRT

<213>  Artificial Sequence



<220>

<223>  Extracellular portion of CD84



<400>  15



Met Ala Gln His His Leu Trp Ile Leu Leu Leu Cys Leu Gln Thr Trp 

1               5                   10                  15      





Pro Glu Ala Ala Gly Lys Asp Ser Glu Ile Phe Thr Val Asn Gly Ile 

            20                  25                  30          





Leu Gly Glu Ser Val Thr Phe Pro Val Asn Ile Gln Glu Pro Arg Gln 

        35                  40                  45              





Val Lys Ile Ile Ala Trp Thr Ser Lys Thr Ser Val Ala Tyr Val Thr 

    50                  55                  60                  





Pro Gly Asp Ser Glu Thr Ala Pro Val Val Thr Val Thr His Arg Asn 

65                  70                  75                  80  





Tyr Tyr Glu Arg Ile His Ala Leu Gly Pro Asn Tyr Asn Leu Val Ile 

                85                  90                  95      





Ser Asp Leu Arg Met Glu Asp Ala Gly Asp Tyr Lys Ala Asp Ile Asn 

            100                 105                 110         





Thr Gln Ala Asp Pro Tyr Thr Thr Leu Met Ala Ser Val Asn Ser Thr 

        115                 120                 125             





Cys Asn Val Thr Leu Thr Cys Ser Val Glu Lys Glu Glu Lys Asn Val 

    130                 135                 140                 





Thr Tyr Asn Trp Ser Pro Leu Gly Glu Glu Gly Asn Val Leu Gln Ile 

145                 150                 155                 160 





Phe Gln Thr Pro Glu Asp Gln Glu Leu Thr Tyr Thr Cys Thr Ala Gln 

                165                 170                 175     





Asn Pro Val Ser Asn Asn Ser Asp Ser Ile Ser Ala Arg Gln Leu Cys 

            180                 185                 190         





Ala Asp Ile Ala Met Gly Phe Arg Glu Phe Cys Arg Tyr Pro Ala Gln 

        195                 200                 205             





Trp Arg Pro Leu Glu Ser Arg Gly Pro Phe Glu Gln Lys Leu Ile Ser 

    210                 215                 220                 





Glu Glu Asp Leu Asn Met His Thr Gly His His His His His His 

225                 230                 235                 





<210>  16

<211>  18

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Single strand DNA oligonucleotide



<400>  16

ggatcaggga gttggaag                                                     18





<210>  17

<211>  16

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Single strand DNA oligonucleotide



<400>  17

gcactgccaa acggag                                                       16





<210>  18

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Single strand DNA oligonucleotide



<400>  18

cgagcagcca gtgctccaag c                                                 21





<210>  19

<211>  24

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Single strand DNA oligonucleotide



<400>  19

ggctgtttgg caacaaccag tcca                                              24





<210>  20

<211>  16

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Single strand DNA oligonucleotide



<400>  20

gctaccgtcg tgactt                                                       16





<210>  21

<211>  16

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Single strand DNA oligonucleotide



<400>  21

gccggttcag gtactc                                                       16





<210>  22

<211>  23

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Single strand DNA oligonucleotide



<400>  22

ccacttcaca agtcggaggc tta                                               23





<210>  23

<211>  25

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Single strand DNA oligonucleotide



<400>  23

gcaagtgcat catcgttgtt catac                                             25





<210>  24

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Single strand DNA oligonucleotide



<400>  24

taccagctcc caaaatcctg                                                   20





<210>  25

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Single strand DNA oligonucleotide



<400>  25

tctgctaatt ccagcctcgt                                                   20





<210>  26

<211>  11456

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  B4 -muIgG2a



<400>  26

attgatcata atcagccata ccacatttgt agaggtttta cttgctttaa aaaacctccc       60



acacctcccc ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat      120



tgcagcttat aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt      180



tttttcactg cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg      240



gcggccgccg atatttgaaa atatggcata ttgaaaatgt cgccgatgtg agtttctgtg      300



taactgatat cgccattttt ccaaaagtga tttttgggca tacgcgatat ctggcgatag      360



cgcttatatc gtttacgggg gatggcgata gacgactttg gtgacttggg cgattctgtg      420



tgtcgcaaat atcgcagttt cgatataggt gacagacgat atgaggctat atcgccgata      480



gaggcgacat caagctggca catggccaat gcatatcgat ctatacattg aatcaatatt      540



ggccattagc catattattc attggttata tagcataaat caatattggc tattggccat      600



tgcatacgtt gtatccatat cataatatgt acatttatat tggctcatgt ccaacattac      660



cgccatgttg acattgatta ttgactagtt attaatagta atcaattacg gggtcattag      720



ttcatagccc atatatggag ttccgcgtta cataacttac ggtaaatggc ccgcctggct      780



gaccgcccaa cgacccccgc ccattgacgt caataatgac gtatgttccc atagtaacgc      840



caatagggac tttccattga cgtcaatggg tggagtattt acggtaaact gcccacttgg      900



cagtacatca agtgtatcat atgccaagta cgccccctat tgacgtcaat gacggtaaat      960



ggcccgcctg gcattatgcc cagtacatga ccttatggga ctttcctact tggcagtaca     1020



tctacgtatt agtcatcgct attaccatgg tgatgcggtt ttggcagtac atcaatgggc     1080



gtggatagcg gtttgactca cggggatttc caagtctcca ccccattgac gtcaatggga     1140



gtttgttttg gcaccaaaat caacgggact ttccaaaatg tcgtaacaac tccgccccat     1200



tgacgcaaat gggcggtagg cgtgtacggt gggaggtcta tataagcaga gctcgtttag     1260



tgaaccgtca gatcgcctgg agacgccatc cacgctgttt tgacctccat agaagacacc     1320



gggaccgatc cagcctccgc ggccgggaac ggtgcattgg aacgcggatt ccccgtgcca     1380



agagtgacgt aagtaccgcc tatagagtct ataggcccac ccccttggct tcttatgcat     1440



gctatactgt ttttggcttg gggtctatac acccccgctt cctcatgtta taggtgatgg     1500



tatagcttag cctataggtg tgggttattg accattattg accactcccc tattggtgac     1560



gatactttcc attactaatc cataacatgg ctctttgcca caactctctt tattggctat     1620



atgccaatac actgtccttc agagactgac acggactctg tatttttaca ggatggggtc     1680



tcatttatta tttacaaatt cacatataca acaccaccgt ccccagtgcc cgcagttttt     1740



attaaacata acgtgggatc tccacgcgaa tctcgggtac gtgttccgga catgggctct     1800



tctccggtag cggcggagct tctacatccg agccctgctc ccatgcctcc agcgactcat     1860



ggtcgctcgg cagctccttg ctcctaacag tggaggccag acttaggcac agcacgatgc     1920



ccaccaccac cagtgtgccg cacaaggccg tggcggtagg gtatgtgtct gaaaatgagc     1980



tcggggagcg ggcttgcacc gctgacgcat ttggaagact taaggcagcg gcagaagaag     2040



atgcaggcag ctgagttgtt gtgttctgat aagagtcaga ggtaactccc gttgcggtgc     2100



tgttaacggt ggagggcagt gtagtctgag cagtactcgt tgctgccgcg cgcgccacca     2160



gacataatag ctgacagact aacagactgt tcctttccat gggtcttttc tgcagtcacc     2220



gtccttgaca cgaagcttgc cgccaccatg ggatggagct gtatcatcct cttcttggta     2280



gcaacagcta caggtgaggt gaagctggtg gagtctgggg ctgagctggc aagacctggg     2340



gcttcagtga agttgtcctg caaggcttct ggctacacct ttactagcta ctggatgcag     2400



tgggtaaaac agaggcctgg acagggtctg gaatggattg gggctattta tcctggagat     2460



ggtgatacta ggtacactca gaagttcaag ggcaaggcca cattgactgc agataaatcc     2520



tccagcacag cctacatgca actcagcagc ttggcatctg aggactctgc ggtctattac     2580



tgtgcaagat tactacgtac ctactggtac ttcgatgtct ggggcgcagg gaccacggtc     2640



accgtctcct cattcgaagc caaaacaaca gccccatcgg tctatccact ggcccctgtg     2700



tgtggagata caactggctc ctcggtgact ctaggatgcc tggtcaaggg ttatttccct     2760



gagccagtga ccttgacctg gaactctgga tccctgtcca gtggtgtgca caccttccca     2820



gctgtcctgc agtctgacct ctacaccctc agcagctcag tgactgtaac ctcgagcacc     2880



tggcccagcc agtccatcac ctgcaatgtg gcccacccgg caagcagcac caaggtggac     2940



aagaaaattg agcccagagg gcccacaatc aagccctgtc ctccatgcaa atgcccagca     3000



cctaacctct tgggtggacc atccgtcttc atcttccctc caaagatcaa ggatgtactc     3060



atgatctccc tgagccccat agtcacatgt gtggtggtgg atgtgagcga ggatgaccca     3120



gatgtccaga tcagctggtt tgtgaacaac gtggaagtac acacagctca gacacaaacc     3180



catagagagg attacaacag tactctccgg gtggtcagtg ccctccccat ccagcaccag     3240



gactggatga gtggcaagga gttcaaatgc aaggtcaaca acaaagacct cccagcgccc     3300



atcgagagaa ccatctcaaa acccaaaggg tcagtaagag ctccacaggt atatgtcttg     3360



cctccaccag aagaagagat gactaagaaa caggtcactc tgacctgcat ggtcacagac     3420



ttcatgcctg aagacattta cgtggagtgg accaacaacg ggaaaacaga gctaaactac     3480



aagaacactg aaccagtcct ggactctgat ggttcttact tcatgtacag caagctgaga     3540



gtggaaaaga agaactgggt ggaaagaaat agctactcct gttcagtggt ccacgagggt     3600



ctgcacaatc accacacgac taagagcttc tcccggactc cgggtaaatg ataagaattc     3660



attgatcata atcagccata ccacatttgt agaggtttta cttgctttaa aaaacctccc     3720



acacctcccc ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat     3780



tgcagcttat aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt     3840



tttttcactg cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg     3900



gatcctctac gccggacgca tcgtggccgg catcaccggc gccacaggtg cggttgctgg     3960



cgcctatatc gccgacatca ccgatgggga agatcgggct cgccacttcg ggctcatgag     4020



cgcttgtttc ggcgtgggta tggtggcagg ccccgtggcc gggggactgt tgggcgccat     4080



ctccttgcat gcaccattcc ttgcggcggc ggtgctcaac ggcctcaacc tactactggg     4140



ctgcttccta atgcaggagt cgcataaggg agagcgtcga cctcgggccg cgttgctggc     4200



gtttttccat aggctccgcc cccctgacga gcatcacaaa aatcgacgct caagtcagag     4260



gtggcgaaac ccgacaggac tataaagata ccaggcgttt ccccctggaa gctccctcgt     4320



gcgctctcct gttccgaccc tgccgcttac cggatacctg tccgcctttc tcccttcggg     4380



aagcgtggcg ctttctcata gctcacgctg taggtatctc agttcggtgt aggtcgttcg     4440



ctccaagctg ggctgtgtgc acgaaccccc cgttcagccc gaccgctgcg ccttatccgg     4500



taactatcgt cttgagtcca acccggtaag acacgactta tcgccactgg cagcagccac     4560



tggtaacagg attagcagag cgaggtatgt aggcggtgct acagagttct tgaagtggtg     4620



gcctaactac ggctacacta gaagaacagt atttggtatc tgcgctctgc tgaagccagt     4680



taccttcgga aaaagagttg gtagctcttg atccggcaaa caaaccaccg ctggtagcgg     4740



tggttttttt gtttgcaagc agcagattac gcgcagaaaa aaaggatctc aagaagatcc     4800



tttgatcttt tctacggggt ctgacgctca gtggaacgaa aactcacgtt aagggatttt     4860



ggtcatgaga ttatcaaaaa ggatcttcac ctagatcctt ttaaattaaa aatgaagttt     4920



taaatcaatc taaagtatat atgagtaaac ttggtctgac agttaccaat gcttaatcag     4980



tgaggcacct atctcagcga tctgtctatt tcgttcatcc atagttgcct gactccccgt     5040



cgtgtagata actacgatac gggagggctt accatctggc cccagtgctg caatgatacc     5100



gcgagaccca cgctcaccgg ctccagattt atcagcaata aaccagccag ccggaagggc     5160



cgagcgcaga agtggtcctg caactttatc cgcctccatc cagtctatta attgttgccg     5220



ggaagctaga gtaagtagtt cgccagttaa tagtttgcgc aacgttgttg ccattgctac     5280



aggcatcgtg gtgtcacgct cgtcgtttgg tatggcttca ttcagctccg gttcccaacg     5340



atcaaggcga gttacatgat cccccatgtt gtgcaaaaaa gcggttagct ccttcggtcc     5400



tccgatcgtt gtcagaagta agttggccgc agtgttatca ctcatggtta tggcagcact     5460



gcataattct cttactgtca tgccatccgt aagatgcttt tctgtgactg gtgagtactc     5520



aaccaagtca ttctgagaat agtgtatgcg gcgaccgagt tgctcttgcc cggcgtcaat     5580



acgggataat accgcgccac atagcagaac tttaaaagtg ctcatcattg gaaaacgttc     5640



ttcggggcga aaactctcaa ggatcttacc gctgttgaga tccagttcga tgtaacccac     5700



tcgtgcaccc aactgatctt cagcatcttt tactttcacc agcgtttctg ggtgagcaaa     5760



aacaggaagg caaaatgccg caaaaaaggg aataagggcg acacggaaat gttgaatact     5820



catactcttc ctttttcaat attattgaag catttatcag ggttattgtc tcatgagcgg     5880



atacatattt gaatgtattt agaaaaataa acaaataggg gttccgcgca catttccccg     5940



aaaagtgcca cctgacgtct aagaaaccat tattatcatg acattaacct ataaaaatag     6000



gcgtatcacg aggccctgat ggctctttgc ggcacccatc gttcgtaatg ttccgtggca     6060



ccgaggacaa ccctcaagag aaaatgtaat cacactggct caccttcggg tgggcctttc     6120



tgcgtttata aggagacact ttatgtttaa gaaggttggt aaattccttg cggctttggc     6180



agccaagcta gatccggctg tggaatgtgt gtcagttagg gtgtggaaag tccccaggct     6240



ccccagcagg cagaagtatg caaagcatgc atctcaatta gtcagcaacc aggtgtggaa     6300



agtccccagg ctccccagca ggcagaagta tgcaaagcat gcatctcaat tagtcagcaa     6360



ccatagtccc gcccctaact ccgcccatcc cgcccctaac tccgcccagt tccgcccatt     6420



ctccgcccca tggctgacta atttttttta tttatgcaga ggccgaggcc gcctcggcct     6480



ctgagctatt ccagaagtag tgaggaggct tttttggagg cctaggcttt tgcaaaaagc     6540



tagcttgggg ccaccgctca gagcaccttc caccatggcc acctcagcaa gttcccactt     6600



gaacaaaaac atcaagcaaa tgtacttgtg cctgccccag ggtgagaaag tccaagccat     6660



gtatatctgg gttgatggta ctggagaagg actgcgctgc aaaacccgca ccctggactg     6720



tgagcccaag tgtgtagaag agttacctga gtggaatttt gatggctcta gtacctttca     6780



gtctgagggc tccaacagtg acatgtatct cagccctgtt gccatgtttc gggacccctt     6840



ccgcagagat cccaacaagc tggtgttctg tgaagttttc aagtacaacc ggaagcctgc     6900



agagaccaat ttaaggcact cgtgtaaacg gataatggac atggtgagca accagcaccc     6960



ctggtttgga atggaacagg agtatactct gatgggaaca gatgggcacc cttttggttg     7020



gccttccaat ggctttcctg ggccccaagg tccgtattac tgtggtgtgg gcgcagacaa     7080



agcctatggc agggatatcg tggaggctca ctaccgcgcc tgcttgtatg ctggggtcaa     7140



gattacagga acaaatgctg aggtcatgcc tgcccagtgg gagttccaaa taggaccctg     7200



tgaaggaatc cgcatgggag atcatctctg ggtggcccgt ttcatcttgc atcgagtatg     7260



tgaagacttt ggggtaatag caacctttga ccccaagccc attcctggga actggaatgg     7320



tgcaggctgc cataccaact ttagcaccaa ggccatgcgg gaggagaatg gtctgaagca     7380



catcgaggag gccatcgaga aactaagcaa gcggcaccgg taccacattc gagcctacga     7440



tcccaagggg ggcctggaca atgcccgtcg tctgactggg ttccacgaaa cgtccaacat     7500



caacgacttt tctgctggtg tcgccaatcg cagtgccagc atccgcattc cccggactgt     7560



cggccaggag aagaaaggtt actttgaaga ccgccgcccc tctgccaatt gtgacccctt     7620



tgcagtgaca gaagccatcg tccgcacatg ccttctcaat gagactggcg acgagccctt     7680



ccaatacaaa aactaattag actttgagtg atcttgagcc tttcctagtt catcccaccc     7740



cgccccagag agatctttgt gaaggaacct tacttctgtg gtgtgacata attggacaaa     7800



ctacctacag agatttaaag ctctaaggta aatataaaat ttttaagtgt ataatgtgtt     7860



aaactactga ttctaattgt ttgtgtattt tagattccaa cctatggaac tgatgaatgg     7920



gagcagtggt ggaatgcctt taatgaggaa aacctgtttt gctcagaaga aatgccatct     7980



agtgatgatg aggctactgc tgactctcaa cattctactc ctccaaaaaa gaagagaaag     8040



gtagaagacc ccaaggactt tccttcagaa ttgctaagtt ttttgagtca tgctgtgttt     8100



agtaatagaa ctcttgcttg ctttgctatt tacaccacaa aggaaaaagc tgcactgcta     8160



tacaagaaaa ttatggaaaa atattctgta acctttataa gtaggcataa cagttataat     8220



cataacatac tgttttttct tactccacac aggcatagag tgtctgctat taataactat     8280



gctcaaaaat tgtgtacctt tagcttttta atttgtaaag gggttaataa ggaatatttg     8340



atgtatagtg ccttgactag agatcataat cagccatacc acatttgtag aggttttact     8400



tgctttaaaa aacctcccac acctccccct gaacctgaaa cataaaatga atgcaattgt     8460



tgttgttaac ttgtttattg cagcttataa tggttacaaa taaagcaata gcatcacaaa     8520



tttcacaaat aaagcatttt tttcactgca ttctagttgt ggtttgtcca aactcatcaa     8580



tgtatcttat catgtctgga tctagcttcg tgtcaaggac ggtgactgca gtgaataata     8640



aaatgtgtgt ttgtccgaaa tacgcgtttt gagatttctg tcgccgacta aattcatgtc     8700



gcgcgatagt ggtgtttatc gccgatagag atggcgatat tggaaaaatc gatatttgaa     8760



aatatggcat attgaaaatg tcgccgatgt gagtttctgt gtaactgata tcgccatttt     8820



tccaaaagtg atttttgggc atacgcgata tctggcgata gcgcttatat cgtttacggg     8880



ggatggcgat agacgacttt ggtgacttgg gcgattctgt gtgtcgcaaa tatcgcagtt     8940



tcgatatagg tgacagacga tatgaggcta tatcgccgat agaggcgaca tcaagctggc     9000



acatggccaa tgcatatcga tctatacatt gaatcaatat tggccattag ccatattatt     9060



cattggttat atagcataaa tcaatattgg ctattggcca ttgcatacgt tgtatccata     9120



tcataatatg tacatttata ttggctcatg tccaacatta ccgccatgtt gacattgatt     9180



attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc catatatgga     9240



gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca acgacccccg     9300



cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga ctttccattg     9360



acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc aagtgtatca     9420



tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc     9480



ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat tagtcatcgc     9540



tattaccatg gtgatgcggt tttggcagta catcaatggg cgtggatagc ggtttgactc     9600



acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt ggcaccaaaa     9660



tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa tgggcggtag     9720



gcgtgtacgg tgggaggtct atataagcag agctcgttta gtgaaccgtc agatcgcctg     9780



gagacgccat ccacgctgtt ttgacctcca tagaagacac cgggaccgat ccagcctccg     9840



cggccgggaa cggtgcattg gaacgcggat tccccgtgcc aagagtgacg taagtaccgc     9900



ctatagagtc tataggccca cccccttggc ttcttatgca tgctatactg tttttggctt     9960



ggggtctata cacccccgct tcctcatgtt ataggtgatg gtatagctta gcctataggt    10020



gtgggttatt gaccattatt gaccactccc ctattggtga cgatactttc cattactaat    10080



ccataacatg gctctttgcc acaactctct ttattggcta tatgccaata cactgtcctt    10140



cagagactga cacggactct gtatttttac aggatggggt ctcatttatt atttacaaat    10200



tcacatatac aacaccaccg tccccagtgc ccgcagtttt tattaaacat aacgtgggat    10260



ctccacgcga atctcgggta cgtgttccgg acatgggctc ttctccggta gcggcggagc    10320



ttctacatcc gagccctgct cccatgcctc cagcgactca tggtcgctcg gcagctcctt    10380



gctcctaaca gtggaggcca gacttaggca cagcacgatg cccaccacca ccagtgtgcc    10440



gcacaaggcc gtggcggtag ggtatgtgtc tgaaaatgag ctcggggagc gggcttgcac    10500



cgctgacgca tttggaagac ttaaggcagc ggcagaagaa gatgcaggca gctgagttgt    10560



tgtgttctga taagagtcag aggtaactcc cgttgcggtg ctgttaacgg tggagggcag    10620



tgtagtctga gcagtactcg ttgctgccgc gcgcgccacc agacataata gctgacagac    10680



taacagactg ttcctttcca tgggtctttt ctgcagtcac cgtccttgac acgaagcttg    10740



ccgccaccat gggatggagc tgtatcatcc tcttcttggt agcaacagct acaggtgaca    10800



ttgtgctgac ccagtctcac aaattcatgt ccacatcagt aggagacagg gtcagcatca    10860



cctgcaaggc cagtcaggat gtgggtactg ctgtagcctg gtatcaacag aaaccagggc    10920



aatctcctaa actactgatt tactgggcat ccacccggca cactggagtc cctgatcgct    10980



tcacaggcag tggatctggg acagatttca ctctcaccat tagcaatgtg cagtctgaag    11040



acttggcaga ttatttctgt cagcaatata gcagctatcc gtacacgttc ggagggggga    11100



ccaagctgga gctgaaacgg cgtacgcgtg ctgatgctgc accaactgta tccatcttcc    11160



caccatccag tgagcagtta acatctggag gtgcctcagt cgtgtgcttc ttgaacaact    11220



tctaccccaa agacatcaat gtcaagtgga agattgatgg cagtgaacga caaaatggcg    11280



tcctgaacag ttggactgat caggacagca aagacagcac ctacagcatg agcagcaccc    11340



tcacgttgac caaggacgag tatgaacgac ataacagcta tacctgtgag gccactcaca    11400



agacatcaac ttcacccatt gtcaagagct tcaacaggaa tgagtgttaa gaattc        11456





<210>  27

<211>  11438

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  B1-mIgG1 sequence



<400>  27

attgatcata atcagccata ccacatttgt agaggtttta cttgctttaa aaaacctccc       60



acacctcccc ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat      120



tgcagcttat aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt      180



tttttcactg cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg      240



gcggccgccg atatttgaaa atatggcata ttgaaaatgt cgccgatgtg agtttctgtg      300



taactgatat cgccattttt ccaaaagtga tttttgggca tacgcgatat ctggcgatag      360



cgcttatatc gtttacgggg gatggcgata gacgactttg gtgacttggg cgattctgtg      420



tgtcgcaaat atcgcagttt cgatataggt gacagacgat atgaggctat atcgccgata      480



gaggcgacat caagctggca catggccaat gcatatcgat ctatacattg aatcaatatt      540



ggccattagc catattattc attggttata tagcataaat caatattggc tattggccat      600



tgcatacgtt gtatccatat cataatatgt acatttatat tggctcatgt ccaacattac      660



cgccatgttg acattgatta ttgactagtt attaatagta atcaattacg gggtcattag      720



ttcatagccc atatatggag ttccgcgtta cataacttac ggtaaatggc ccgcctggct      780



gaccgcccaa cgacccccgc ccattgacgt caataatgac gtatgttccc atagtaacgc      840



caatagggac tttccattga cgtcaatggg tggagtattt acggtaaact gcccacttgg      900



cagtacatca agtgtatcat atgccaagta cgccccctat tgacgtcaat gacggtaaat      960



ggcccgcctg gcattatgcc cagtacatga ccttatggga ctttcctact tggcagtaca     1020



tctacgtatt agtcatcgct attaccatgg tgatgcggtt ttggcagtac atcaatgggc     1080



gtggatagcg gtttgactca cggggatttc caagtctcca ccccattgac gtcaatggga     1140



gtttgttttg gcaccaaaat caacgggact ttccaaaatg tcgtaacaac tccgccccat     1200



tgacgcaaat gggcggtagg cgtgtacggt gggaggtcta tataagcaga gctcgtttag     1260



tgaaccgtca gatcgcctgg agacgccatc cacgctgttt tgacctccat agaagacacc     1320



gggaccgatc cagcctccgc ggccgggaac ggtgcattgg aacgcggatt ccccgtgcca     1380



agagtgacgt aagtaccgcc tatagagtct ataggcccac ccccttggct tcttatgcat     1440



gctatactgt ttttggcttg gggtctatac acccccgctt cctcatgtta taggtgatgg     1500



tatagcttag cctataggtg tgggttattg accattattg accactcccc tattggtgac     1560



gatactttcc attactaatc cataacatgg ctctttgcca caactctctt tattggctat     1620



atgccaatac actgtccttc agagactgac acggactctg tatttttaca ggatggggtc     1680



tcatttatta tttacaaatt cacatataca acaccaccgt ccccagtgcc cgcagttttt     1740



attaaacata acgtgggatc tccacgcgaa tctcgggtac gtgttccgga catgggctct     1800



tctccggtag cggcggagct tctacatccg agccctgctc ccatgcctcc agcgactcat     1860



ggtcgctcgg cagctccttg ctcctaacag tggaggccag acttaggcac agcacgatgc     1920



ccaccaccac cagtgtgccg cacaaggccg tggcggtagg gtatgtgtct gaaaatgagc     1980



tcggggagcg ggcttgcacc gctgacgcat ttggaagact taaggcagcg gcagaagaag     2040



atgcaggcag ctgagttgtt gtgttctgat aagagtcaga ggtaactccc gttgcggtgc     2100



tgttaacggt ggagggcagt gtagtctgag cagtactcgt tgctgccgcg cgcgccacca     2160



gacataatag ctgacagact aacagactgt tcctttccat gggtcttttc tgcagtcacc     2220



gtccttgaca cgaagcttgc cgccaccatg ggatggagct gtatcatcct cttcttggta     2280



gcaacagcta caggtgaggt gaagctggtg gaatctgggg gaggcttagt gcagcctgga     2340



gggtcccgga aactctcctg tgcagcctct ggattcactt tcagtagctt tggaatgcac     2400



tgggttcgtc aggctccaga gaaggggctg gagtgggtcg catacattag tagtggcagt     2460



agtaccatct actatgcaga cacagtgaag ggccgattca ccatctccag agacaatccc     2520



aagaacaccc tgttcctgca aatgaccagt ctaaggtctg aggacacggc catgtattac     2580



tgtgcaagat gggggtggac tgggacagga cttgactact ggggccaagg caccactctc     2640



acagtctcct cattcgaagc caaaacgaca cccccatctg tctatccact ggcccctgga     2700



tctgctgccc aaactaactc catggtgacc ctgggatgcc tggtcaaggg ctatttccct     2760



gagccagtga cagtgacctg gaactctgga tccctgtcca gcggtgtgca caccttccca     2820



gctgtcctgc agtctgacct ctacactctg agcagctcag tgactgtccc ctccagcacc     2880



tggcccagcg agaccgtcac ctgcaacgtt gcccacccgg ccagcagcac caaggtggac     2940



aagaaaattg tgcccaggga ttgtggttgt aagccttgca tatgtacagt cccagaagta     3000



tcatctgtct tcatcttccc cccaaagccc aaggatgtgc tcaccattac tctgactcct     3060



aaggtcacgt gtgttgtggt agacatcagc aaggatgatc ccgaggtcca gttcagctgg     3120



tttgtagatg atgtggaggt gcacacagct cagacgcaac cccgggagga gcagttcaac     3180



agcactttcc gctcagtcag tgaacttccc atcatgcacc aggactggct caatggcaag     3240



gagttcaaat gcagggtcaa cagtgcagct ttccctgccc ccatcgagaa aaccatctcc     3300



aaaaccaaag gcagaccgaa ggctccacag gtgtacacca ttccacctcc caaggagcag     3360



atggccaagg ataaagtcag tctgacctgc atgataacag acttcttccc tgaagacatt     3420



actgtggagt ggcagtggaa tgggcagcca gcggagaact acaagaacac tcagcccatc     3480



atggacacag atggctctta cttcgtctac agcaagctca atgtgcagaa gagcaactgg     3540



gaggcaggaa atactttcac ctgctctgtg ttacatgagg gcctgcacaa ccaccatact     3600



gagaagagcc tctcccactc tcctggtaaa tgagaattca ttgatcataa tcagccatac     3660



cacatttgta gaggttttac ttgctttaaa aaacctccca cacctccccc tgaacctgaa     3720



acataaaatg aatgcaattg ttgttgttaa cttgtttatt gcagcttata atggttacaa     3780



ataaagcaat agcatcacaa atttcacaaa taaagcattt ttttcactgc attctagttg     3840



tggtttgtcc aaactcatca atgtatctta tcatgtctgg atcctctacg ccggacgcat     3900



cgtggccggc atcaccggcg ccacaggtgc ggttgctggc gcctatatcg ccgacatcac     3960



cgatggggaa gatcgggctc gccacttcgg gctcatgagc gcttgtttcg gcgtgggtat     4020



ggtggcaggc cccgtggccg ggggactgtt gggcgccatc tccttgcatg caccattcct     4080



tgcggcggcg gtgctcaacg gcctcaacct actactgggc tgcttcctaa tgcaggagtc     4140



gcataaggga gagcgtcgac ctcgggccgc gttgctggcg tttttccata ggctccgccc     4200



ccctgacgag catcacaaaa atcgacgctc aagtcagagg tggcgaaacc cgacaggact     4260



ataaagatac caggcgtttc cccctggaag ctccctcgtg cgctctcctg ttccgaccct     4320



gccgcttacc ggatacctgt ccgcctttct cccttcggga agcgtggcgc tttctcatag     4380



ctcacgctgt aggtatctca gttcggtgta ggtcgttcgc tccaagctgg gctgtgtgca     4440



cgaacccccc gttcagcccg accgctgcgc cttatccggt aactatcgtc ttgagtccaa     4500



cccggtaaga cacgacttat cgccactggc agcagccact ggtaacagga ttagcagagc     4560



gaggtatgta ggcggtgcta cagagttctt gaagtggtgg cctaactacg gctacactag     4620



aagaacagta tttggtatct gcgctctgct gaagccagtt accttcggaa aaagagttgg     4680



tagctcttga tccggcaaac aaaccaccgc tggtagcggt ggtttttttg tttgcaagca     4740



gcagattacg cgcagaaaaa aaggatctca agaagatcct ttgatctttt ctacggggtc     4800



tgacgctcag tggaacgaaa actcacgtta agggattttg gtcatgagat tatcaaaaag     4860



gatcttcacc tagatccttt taaattaaaa atgaagtttt aaatcaatct aaagtatata     4920



tgagtaaact tggtctgaca gttaccaatg cttaatcagt gaggcaccta tctcagcgat     4980



ctgtctattt cgttcatcca tagttgcctg actccccgtc gtgtagataa ctacgatacg     5040



ggagggctta ccatctggcc ccagtgctgc aatgataccg cgagacccac gctcaccggc     5100



tccagattta tcagcaataa accagccagc cggaagggcc gagcgcagaa gtggtcctgc     5160



aactttatcc gcctccatcc agtctattaa ttgttgccgg gaagctagag taagtagttc     5220



gccagttaat agtttgcgca acgttgttgc cattgctaca ggcatcgtgg tgtcacgctc     5280



gtcgtttggt atggcttcat tcagctccgg ttcccaacga tcaaggcgag ttacatgatc     5340



ccccatgttg tgcaaaaaag cggttagctc cttcggtcct ccgatcgttg tcagaagtaa     5400



gttggccgca gtgttatcac tcatggttat ggcagcactg cataattctc ttactgtcat     5460



gccatccgta agatgctttt ctgtgactgg tgagtactca accaagtcat tctgagaata     5520



gtgtatgcgg cgaccgagtt gctcttgccc ggcgtcaata cgggataata ccgcgccaca     5580



tagcagaact ttaaaagtgc tcatcattgg aaaacgttct tcggggcgaa aactctcaag     5640



gatcttaccg ctgttgagat ccagttcgat gtaacccact cgtgcaccca actgatcttc     5700



agcatctttt actttcacca gcgtttctgg gtgagcaaaa acaggaaggc aaaatgccgc     5760



aaaaaaggga ataagggcga cacggaaatg ttgaatactc atactcttcc tttttcaata     5820



ttattgaagc atttatcagg gttattgtct catgagcgga tacatatttg aatgtattta     5880



gaaaaataaa caaatagggg ttccgcgcac atttccccga aaagtgccac ctgacgtcta     5940



agaaaccatt attatcatga cattaaccta taaaaatagg cgtatcacga ggccctgatg     6000



gctctttgcg gcacccatcg ttcgtaatgt tccgtggcac cgaggacaac cctcaagaga     6060



aaatgtaatc acactggctc accttcgggt gggcctttct gcgtttataa ggagacactt     6120



tatgtttaag aaggttggta aattccttgc ggctttggca gccaagctag atccggctgt     6180



ggaatgtgtg tcagttaggg tgtggaaagt ccccaggctc cccagcaggc agaagtatgc     6240



aaagcatgca tctcaattag tcagcaacca ggtgtggaaa gtccccaggc tccccagcag     6300



gcagaagtat gcaaagcatg catctcaatt agtcagcaac catagtcccg cccctaactc     6360



cgcccatccc gcccctaact ccgcccagtt ccgcccattc tccgccccat ggctgactaa     6420



ttttttttat ttatgcagag gccgaggccg cctcggcctc tgagctattc cagaagtagt     6480



gaggaggctt ttttggaggc ctaggctttt gcaaaaagct agcttggggc caccgctcag     6540



agcaccttcc accatggcca cctcagcaag ttcccacttg aacaaaaaca tcaagcaaat     6600



gtacttgtgc ctgccccagg gtgagaaagt ccaagccatg tatatctggg ttgatggtac     6660



tggagaagga ctgcgctgca aaacccgcac cctggactgt gagcccaagt gtgtagaaga     6720



gttacctgag tggaattttg atggctctag tacctttcag tctgagggct ccaacagtga     6780



catgtatctc agccctgttg ccatgtttcg ggaccccttc cgcagagatc ccaacaagct     6840



ggtgttctgt gaagttttca agtacaaccg gaagcctgca gagaccaatt taaggcactc     6900



gtgtaaacgg ataatggaca tggtgagcaa ccagcacccc tggtttggaa tggaacagga     6960



gtatactctg atgggaacag atgggcaccc ttttggttgg ccttccaatg gctttcctgg     7020



gccccaaggt ccgtattact gtggtgtggg cgcagacaaa gcctatggca gggatatcgt     7080



ggaggctcac taccgcgcct gcttgtatgc tggggtcaag attacaggaa caaatgctga     7140



ggtcatgcct gcccagtggg agttccaaat aggaccctgt gaaggaatcc gcatgggaga     7200



tcatctctgg gtggcccgtt tcatcttgca tcgagtatgt gaagactttg gggtaatagc     7260



aacctttgac cccaagccca ttcctgggaa ctggaatggt gcaggctgcc ataccaactt     7320



tagcaccaag gccatgcggg aggagaatgg tctgaagcac atcgaggagg ccatcgagaa     7380



actaagcaag cggcaccggt accacattcg agcctacgat cccaaggggg gcctggacaa     7440



tgcccgtcgt ctgactgggt tccacgaaac gtccaacatc aacgactttt ctgctggtgt     7500



cgccaatcgc agtgccagca tccgcattcc ccggactgtc ggccaggaga agaaaggtta     7560



ctttgaagac cgccgcccct ctgccaattg tgaccccttt gcagtgacag aagccatcgt     7620



ccgcacatgc cttctcaatg agactggcga cgagcccttc caatacaaaa actaattaga     7680



ctttgagtga tcttgagcct ttcctagttc atcccacccc gccccagaga gatctttgtg     7740



aaggaacctt acttctgtgg tgtgacataa ttggacaaac tacctacaga gatttaaagc     7800



tctaaggtaa atataaaatt tttaagtgta taatgtgtta aactactgat tctaattgtt     7860



tgtgtatttt agattccaac ctatggaact gatgaatggg agcagtggtg gaatgccttt     7920



aatgaggaaa acctgttttg ctcagaagaa atgccatcta gtgatgatga ggctactgct     7980



gactctcaac attctactcc tccaaaaaag aagagaaagg tagaagaccc caaggacttt     8040



ccttcagaat tgctaagttt tttgagtcat gctgtgttta gtaatagaac tcttgcttgc     8100



tttgctattt acaccacaaa ggaaaaagct gcactgctat acaagaaaat tatggaaaaa     8160



tattctgtaa cctttataag taggcataac agttataatc ataacatact gttttttctt     8220



actccacaca ggcatagagt gtctgctatt aataactatg ctcaaaaatt gtgtaccttt     8280



agctttttaa tttgtaaagg ggttaataag gaatatttga tgtatagtgc cttgactaga     8340



gatcataatc agccatacca catttgtaga ggttttactt gctttaaaaa acctcccaca     8400



cctccccctg aacctgaaac ataaaatgaa tgcaattgtt gttgttaact tgtttattgc     8460



agcttataat ggttacaaat aaagcaatag catcacaaat ttcacaaata aagcattttt     8520



ttcactgcat tctagttgtg gtttgtccaa actcatcaat gtatcttatc atgtctggat     8580



ctagcttcgt gtcaaggacg gtgactgcag tgaataataa aatgtgtgtt tgtccgaaat     8640



acgcgttttg agatttctgt cgccgactaa attcatgtcg cgcgatagtg gtgtttatcg     8700



ccgatagaga tggcgatatt ggaaaaatcg atatttgaaa atatggcata ttgaaaatgt     8760



cgccgatgtg agtttctgtg taactgatat cgccattttt ccaaaagtga tttttgggca     8820



tacgcgatat ctggcgatag cgcttatatc gtttacgggg gatggcgata gacgactttg     8880



gtgacttggg cgattctgtg tgtcgcaaat atcgcagttt cgatataggt gacagacgat     8940



atgaggctat atcgccgata gaggcgacat caagctggca catggccaat gcatatcgat     9000



ctatacattg aatcaatatt ggccattagc catattattc attggttata tagcataaat     9060



caatattggc tattggccat tgcatacgtt gtatccatat cataatatgt acatttatat     9120



tggctcatgt ccaacattac cgccatgttg acattgatta ttgactagtt attaatagta     9180



atcaattacg gggtcattag ttcatagccc atatatggag ttccgcgtta cataacttac     9240



ggtaaatggc ccgcctggct gaccgcccaa cgacccccgc ccattgacgt caataatgac     9300



gtatgttccc atagtaacgc caatagggac tttccattga cgtcaatggg tggagtattt     9360



acggtaaact gcccacttgg cagtacatca agtgtatcat atgccaagta cgccccctat     9420



tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc cagtacatga ccttatggga     9480



ctttcctact tggcagtaca tctacgtatt agtcatcgct attaccatgg tgatgcggtt     9540



ttggcagtac atcaatgggc gtggatagcg gtttgactca cggggatttc caagtctcca     9600



ccccattgac gtcaatggga gtttgttttg gcaccaaaat caacgggact ttccaaaatg     9660



tcgtaacaac tccgccccat tgacgcaaat gggcggtagg cgtgtacggt gggaggtcta     9720



tataagcaga gctcgtttag tgaaccgtca gatcgcctgg agacgccatc cacgctgttt     9780



tgacctccat agaagacacc gggaccgatc cagcctccgc ggccgggaac ggtgcattgg     9840



aacgcggatt ccccgtgcca agagtgacgt aagtaccgcc tatagagtct ataggcccac     9900



ccccttggct tcttatgcat gctatactgt ttttggcttg gggtctatac acccccgctt     9960



cctcatgtta taggtgatgg tatagcttag cctataggtg tgggttattg accattattg    10020



accactcccc tattggtgac gatactttcc attactaatc cataacatgg ctctttgcca    10080



caactctctt tattggctat atgccaatac actgtccttc agagactgac acggactctg    10140



tatttttaca ggatggggtc tcatttatta tttacaaatt cacatataca acaccaccgt    10200



ccccagtgcc cgcagttttt attaaacata acgtgggatc tccacgcgaa tctcgggtac    10260



gtgttccgga catgggctct tctccggtag cggcggagct tctacatccg agccctgctc    10320



ccatgcctcc agcgactcat ggtcgctcgg cagctccttg ctcctaacag tggaggccag    10380



acttaggcac agcacgatgc ccaccaccac cagtgtgccg cacaaggccg tggcggtagg    10440



gtatgtgtct gaaaatgagc tcggggagcg ggcttgcacc gctgacgcat ttggaagact    10500



taaggcagcg gcagaagaag atgcaggcag ctgagttgtt gtgttctgat aagagtcaga    10560



ggtaactccc gttgcggtgc tgttaacggt ggagggcagt gtagtctgag cagtactcgt    10620



tgctgccgcg cgcgccacca gacataatag ctgacagact aacagactgt tcctttccat    10680



gggtcttttc tgcagtcacc gtccttgaca cgaagcttgc cgccaccatg ggatggagct    10740



gtatcatcct cttcttggta gcaacagcta caggtgatat tgtgctaact cagtctccag    10800



cactcatggc tgcatctcca ggggagaagg tcaccatcac ctgcagtgtc agctcaagta    10860



taagttccag caacttgcac tggtaccagc agaagtcaga aacctccccc aaaccctgga    10920



tttatggcac atccaacctg gcttctggag tccctgttcg cttcagtggc agtggatctg    10980



ggacctctta ttctctcaca atcagcagca tggaggctga agatgctgcc acttattact    11040



gtcaacagtg gagtagttac ccattcacgt tcggctcggg gaccaagctg gaaataaaac    11100



ggcgtacgcg tgctgatgct gcaccaactg tatccatctt cccaccatcc agtgagcagt    11160



taacatctgg aggtgcctca gtcgtgtgct tcttgaacaa cttctacccc aaagacatca    11220



atgtcaagtg gaagattgat ggcagtgaac gacaaaatgg cgtcctgaac agttggactg    11280



atcaggacag caaagacagc acctacagca tgagcagcac cctcacgttg accaaggacg    11340



agtatgaacg acataacagc tatacctgtg aggccactca caagacatca acttcaccca    11400



ttgtcaagag cttcaacagg aatgagtgtt aagaattc                            11438





<210>  28

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Single strand DNA oligonucleotide



<400>  28

ttgttccgtt tgttcaagag                                                   20





<210>  29

<211>  21

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Single strand DNA oligonucleotide



<400>  29

cggaataaac tgtgttcact g                                                 21





