               SEQUENCE LISTING

<110> Celltrend GmbH

<120> Diagnosis of cancer by detecting auto-antibodies against PAR1

<130> W2688 PCT BLN

<150> EP14153826.4
<151> 2014-02-04

<160> 2

<170> BiSSAP 1.3

<210> 1
<211> 425
<212> PRT
<213> Homo sapiens

<220> 
<223> Amino acid sequence of the human PAR1 receptor (isoform 1)

<400> 1
Met Gly Pro Arg Arg Leu Leu Leu Val Ala Ala Cys Phe Ser Leu Cys 
1               5                   10                  15      
Gly Pro Leu Leu Ser Ala Arg Thr Arg Ala Arg Arg Pro Glu Ser Lys 
            20                  25                  30          
Ala Thr Asn Ala Thr Leu Asp Pro Arg Ser Phe Leu Leu Arg Asn Pro 
        35                  40                  45              
Asn Asp Lys Tyr Glu Pro Phe Trp Glu Asp Glu Glu Lys Asn Glu Ser 
    50                  55                  60                  
Gly Leu Thr Glu Tyr Arg Leu Val Ser Ile Asn Lys Ser Ser Pro Leu 
65                  70                  75                  80  
Gln Lys Gln Leu Pro Ala Phe Ile Ser Glu Asp Ala Ser Gly Tyr Leu 
                85                  90                  95      
Thr Ser Ser Trp Leu Thr Leu Phe Val Pro Ser Val Tyr Thr Gly Val 
            100                 105                 110         
Phe Val Val Ser Leu Pro Leu Asn Ile Met Ala Ile Val Val Phe Ile 
        115                 120                 125             
Leu Lys Met Lys Val Lys Lys Pro Ala Val Val Tyr Met Leu His Leu 
    130                 135                 140                 
Ala Thr Ala Asp Val Leu Phe Val Ser Val Leu Pro Phe Lys Ile Ser 
145                 150                 155                 160 
Tyr Tyr Phe Ser Gly Ser Asp Trp Gln Phe Gly Ser Glu Leu Cys Arg 
                165                 170                 175     
Phe Val Thr Ala Ala Phe Tyr Cys Asn Met Tyr Ala Ser Ile Leu Leu 
            180                 185                 190         
Met Thr Val Ile Ser Ile Asp Arg Phe Leu Ala Val Val Tyr Pro Met 
        195                 200                 205             
Gln Ser Leu Ser Trp Arg Thr Leu Gly Arg Ala Ser Phe Thr Cys Leu 
    210                 215                 220                 
Ala Ile Trp Ala Leu Ala Ile Ala Gly Val Val Pro Leu Leu Leu Lys 
225                 230                 235                 240 
Glu Gln Thr Ile Gln Val Pro Gly Leu Asn Ile Thr Thr Cys His Asp 
                245                 250                 255     
Val Leu Asn Glu Thr Leu Leu Glu Gly Tyr Tyr Ala Tyr Tyr Phe Ser 
            260                 265                 270         
Ala Phe Ser Ala Val Phe Phe Phe Val Pro Leu Ile Ile Ser Thr Val 
        275                 280                 285             
Cys Tyr Val Ser Ile Ile Arg Cys Leu Ser Ser Ser Ala Val Ala Asn 
    290                 295                 300                 
Arg Ser Lys Lys Ser Arg Ala Leu Phe Leu Ser Ala Ala Val Phe Cys 
305                 310                 315                 320 
Ile Phe Ile Ile Cys Phe Gly Pro Thr Asn Val Leu Leu Ile Val His 
                325                 330                 335     
Tyr Ser Phe Leu Ser His Thr Ser Thr Thr Glu Ala Ala Tyr Phe Ala 
            340                 345                 350         
Tyr Leu Leu Cys Val Cys Val Ser Ser Ile Ser Cys Cys Ile Asp Pro 
        355                 360                 365             
Leu Ile Tyr Tyr Tyr Ala Ser Ser Glu Cys Gln Arg Tyr Val Tyr Ser 
    370                 375                 380                 
Ile Leu Cys Cys Lys Glu Ser Ser Asp Pro Ser Ser Tyr Asn Ser Ser 
385                 390                 395                 400 
Gly Gln Leu Met Ala Ser Lys Met Asp Thr Cys Ser Ser Asn Leu Asn 
                405                 410                 415     
Asn Ser Ile Tyr Lys Lys Leu Leu Thr 
            420                 425 

<210> 2
<211> 425
<212> PRT
<213> Homo sapiens

<220> 
<223> Amino acid sequence of the human PAR1 receptor (isoform 2)

<400> 2
Met Gly Pro Arg Arg Leu Leu Leu Val Ala Ala Cys Phe Ser Leu Cys 
1               5                   10                  15      
Gly Pro Leu Leu Ser Ala Arg Thr Arg Ala Arg Arg Pro Glu Ser Lys 
            20                  25                  30          
Ala Thr Asn Ala Thr Leu Asp Pro Arg Ser Phe Leu Leu Arg Asn Pro 
        35                  40                  45              
Asn Asp Lys Tyr Glu Pro Phe Trp Glu Asp Glu Glu Lys Asn Glu Ser 
    50                  55                  60                  
Gly Leu Thr Glu Tyr Arg Leu Val Ser Ile Asn Lys Ser Ser Pro Leu 
65                  70                  75                  80  
Gln Lys Gln Leu Pro Ala Phe Ile Ser Glu Asp Ala Ser Gly Tyr Leu 
                85                  90                  95      
Thr Ser Ser Trp Leu Thr Leu Phe Val Pro Ser Val Tyr Thr Gly Val 
            100                 105                 110         
Phe Val Val Ser Leu Pro Leu Asn Ile Met Ala Ile Val Val Phe Ile 
        115                 120                 125             
Leu Lys Met Lys Val Lys Lys Pro Ala Val Val Tyr Met Leu His Leu 
    130                 135                 140                 
Ala Thr Ala Asp Val Leu Phe Val Ser Val Leu Pro Phe Lys Ile Ser 
145                 150                 155                 160 
Tyr Tyr Phe Ser Gly Ser Asp Trp Gln Phe Gly Ser Glu Leu Cys Arg 
                165                 170                 175     
Phe Val Thr Ala Ala Phe Tyr Cys Asn Met Tyr Ala Ser Ile Leu Leu 
            180                 185                 190         
Met Thr Val Ile Ser Ile Asp Arg Phe Leu Ala Val Val Tyr Pro Met 
        195                 200                 205             
Gln Ser Leu Ser Trp Arg Thr Leu Gly Arg Ala Ser Phe Thr Cys Leu 
    210                 215                 220                 
Ala Ile Trp Ala Leu Ala Ile Ala Gly Val Val Pro Leu Leu Leu Lys 
225                 230                 235                 240 
Glu Gln Thr Ile Gln Val Pro Gly Leu Asn Ile Thr Thr Cys His Asp 
                245                 250                 255     
Val Leu Asn Glu Thr Leu Leu Glu Gly Tyr Tyr Ala Tyr Tyr Phe Ser 
            260                 265                 270         
Ala Phe Ser Ala Val Phe Phe Phe Val Pro Leu Ile Ile Ser Thr Val 
        275                 280                 285             
Cys Tyr Val Ser Ile Ile Arg Cys Leu Ser Ser Ser Ala Val Ala Asn 
    290                 295                 300                 
Arg Ser Lys Lys Ser Arg Ala Leu Phe Leu Ser Ala Ala Val Phe Cys 
305                 310                 315                 320 
Ile Phe Ile Ile Cys Phe Gly Pro Thr Asn Val Leu Leu Ile Ala His 
                325                 330                 335     
Tyr Ser Phe Leu Ser His Thr Ser Thr Thr Glu Ala Ala Tyr Phe Ala 
            340                 345                 350         
Tyr Leu Leu Cys Val Cys Val Ser Ser Ile Ser Cys Cys Ile Asp Pro 
        355                 360                 365             
Leu Ile Tyr Tyr Tyr Ala Ser Ser Glu Cys Gln Arg Tyr Val Tyr Ser 
    370                 375                 380                 
Ile Leu Cys Cys Lys Glu Ser Ser Asp Pro Ser Ser Tyr Asn Ser Ser 
385                 390                 395                 400 
Gly Gln Leu Met Ala Ser Lys Met Asp Thr Cys Ser Ser Asn Leu Asn 
                405                 410                 415     
Asn Ser Ile Tyr Lys Lys Leu Leu Thr 
            420                 425 

