                         SEQUENCE LISTING

<110>  McMaster University
 
<120>  TRIFUNCTIONAL T CELL-ANTIGEN COUPLER AND METHODS AND USES THEREOF

<130>  3244-P47791PC00

<150>  US 61/936,906
<151>  2014-02-07

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  1575
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1
atggatttcc aggtccagat tttctccttc ctgctgattt ccgcaagcgt cattatgtca       60

cggggctccg acctgggcaa aaagctgctg gaggccgcta gggccgggca ggacgatgaa      120

gtgagaatcc tgatggccaa cggggctgac gtgaatgcta aggatgagta cggcctgacc      180

cccctgtatc tggctacagc acacggccat ctggagatcg tggaagtcct gctgaaaaac      240

ggagccgacg tgaatgcagt cgatgccatt gggttcactc ctctgcacct ggcagccttt      300

atcggacatc tggagattgc agaagtgctg ctgaagcacg gcgctgacgt gaacgcacag      360

gataagttcg gaaaaaccgc ttttgacatc agcattggca acggaaatga agacctggct      420

gaaatcctgc agaaactgaa tgaacagaaa ctgattagcg aagaagacct gaaccccggg      480

ggaggaggag ggagcggggg aggaggcagc ggcgggggag gctctggagg aggagggagc      540

ggatccatgg acatccagat gactcagacc acaagctccc tgtctgcaag tctgggcgac      600

cgggtgacaa tctcctgcag agcctctcag gatattagga actacctgaa ttggtatcag      660

cagaaacctg atggcacagt caagctgctg atctactata ccagccggct gcactcaggc      720

gtgccaagca aattctcagg aagcggctcc gggactgact actccctgac catctctaac      780

ctggagcagg aagatattgc tacctatttc tgccagcagg gcaatacact gccctggact      840

tttgccggag gcaccaaact ggagatcaag gggggaggcg ggagtggagg cgggggatca      900

ggaggaggag gcagcggagg aggagggtcc gaggtccagc tgcagcagag cggaccagaa      960

ctggtgaagc ccggagcaag tatgaaaatc tcctgtaagg cctcaggata cagcttcacc     1020

ggctatacaa tgaactgggt gaaacagtcc catggcaaga acctggaatg gatggggctg     1080

attaatcctt acaaaggcgt cagcacctat aatcagaagt ttaaagacaa ggccacactg     1140

actgtggata agtctagttc aaccgcttac atggagctgc tgtccctgac atctgaagac     1200

agtgccgtgt actattgtgc tcggtctggc tactatgggg acagtgattg gtacttcgat     1260

gtctggggac agggcactac cctgaccgtg ttttctacta gtggcggagg aggatcactc     1320

gagagcggac aggtgctgct ggaatccaat atcaaagtcc tgcccacttg gtctaccccc     1380

gtgcagccta tggctctgat tgtgctggga ggagtcgcag gactgctgct gtttatcggg     1440

ctgggaattt tcttttgcgt gcgctgccgg caccggagaa ggcaggccga gcgcatgagc     1500

cagatcaagc gactgctgag cgagaagaaa acctgtcagt gtccccatag attccagaag     1560

acctgttcac ccatt                                                      1575


<210>  2
<211>  525
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala 
            20                  25                  30          


Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly 
        35                  40                  45              


Ala Asp Val Asn Ala Lys Asp Glu Tyr Gly Leu Thr Pro Leu Tyr Leu 
    50                  55                  60                  


Ala Thr Ala His Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Asn 
65                  70                  75                  80  


Gly Ala Asp Val Asn Ala Val Asp Ala Ile Gly Phe Thr Pro Leu His 
                85                  90                  95      


Leu Ala Ala Phe Ile Gly His Leu Glu Ile Ala Glu Val Leu Leu Lys 
            100                 105                 110         


His Gly Ala Asp Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe 
        115                 120                 125             


Asp Ile Ser Ile Gly Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln 
    130                 135                 140                 


Lys Leu Asn Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Pro Gly 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                165                 170                 175     


Gly Gly Gly Ser Gly Ser Met Asp Ile Gln Met Thr Gln Thr Thr Ser 
            180                 185                 190         


Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala 
        195                 200                 205             


Ser Gln Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp 
    210                 215                 220                 


Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly 
225                 230                 235                 240 


Val Pro Ser Lys Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu 
                245                 250                 255     


Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln 
            260                 265                 270         


Gln Gly Asn Thr Leu Pro Trp Thr Phe Ala Gly Gly Thr Lys Leu Glu 
        275                 280                 285             


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    290                 295                 300                 


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu 
305                 310                 315                 320 


Leu Val Lys Pro Gly Ala Ser Met Lys Ile Ser Cys Lys Ala Ser Gly 
                325                 330                 335     


Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly 
            340                 345                 350         


Lys Asn Leu Glu Trp Met Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser 
        355                 360                 365             


Thr Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys 
    370                 375                 380                 


Ser Ser Ser Thr Ala Tyr Met Glu Leu Leu Ser Leu Thr Ser Glu Asp 
385                 390                 395                 400 


Ser Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp 
                405                 410                 415     


Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Thr Leu Thr Val Phe Ser 
            420                 425                 430         


Thr Ser Gly Gly Gly Gly Ser Leu Glu Ser Gly Gln Val Leu Leu Glu 
        435                 440                 445             


Ser Asn Ile Lys Val Leu Pro Thr Trp Ser Thr Pro Val Gln Pro Met 
    450                 455                 460                 


Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly 
465                 470                 475                 480 


Leu Gly Ile Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln Ala 
                485                 490                 495     


Glu Arg Met Ser Gln Ile Lys Arg Leu Leu Ser Glu Lys Lys Thr Cys 
            500                 505                 510         


Gln Cys Pro His Arg Phe Gln Lys Thr Cys Ser Pro Ile 
        515                 520                 525 


<210>  3
<211>  1647
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3
atggactttc aggtgcagat tttctctttt ctgctgattt ccgcaagcgt catcgagctc       60

gggggggggg ggtcaggatc catggacatc cagatgactc agaccacaag ctccctgagc      120

gcatccctgg gcgaccgagt gacaatctca tgcagagcca gccaggatat taggaactac      180

ctgaattggt atcagcagaa acctgacggc acagtcaagc tgctgatcta ctatacttcc      240

cggctgcact ctggcgtgcc aagtaaattc tctgggagtg gatcaggcac tgactactca      300

ctgaccatca gcaacctgga gcaggaagat attgctacct atttctgcca gcagggcaat      360

acactgccct ggacttttgc aggcgggacc aaactggaga tcaagggcgg cggcggaagt      420

ggaggaggag gctcaggcgg aggagggagc ggcggaggag gcagcgaggt ccagctgcag      480

cagagcggac cagaactggt gaagcctggc gcatccatga aaatctcttg taaggcctct      540

gggtacagtt tcaccggata tacaatgaac tgggtgaaac agtctcatgg caagaacctg      600

gaatggatgg gcctgattaa tccttacaaa ggcgtcagca cctataatca gaagtttaaa      660

gacaaggcca cactgactgt ggataagtct agttcaaccg cttacatgga gctgctgtca      720

ctgacaagcg aagactccgc cgtgtactat tgcgctagga gcggatacta tggcgactcc      780

gattggtact tcgatgtctg ggggcaggga actaccctga ccgtgtttag cactagtgga      840

ggaggaggct ctggaggagg agggagtgga ggcgggggat caggaggagg aggcagcgat      900

atcatgtcac ggggctccga cctgggcaaa aagctgctgg aggccgctag ggccgggcag      960

gacgatgaag tgagaatcct gatggccaac ggggctgacg tgaatgctaa ggatgagtac     1020

ggcctgaccc ccctgtatct ggctacagca cacggccatc tggagatcgt ggaagtcctg     1080

ctgaaaaacg gagccgacgt gaatgcagtc gatgccattg ggttcactcc tctgcacctg     1140

gcagccttta tcggacatct ggagattgca gaagtgctgc tgaagcacgg cgctgacgtg     1200

aacgcacagg ataagttcgg aaaaaccgct tttgacatca gcattggcaa cggaaatgaa     1260

gacctggctg aaatcctgca gaaactgaat gaacagaaac tgattagcga agaagacctg     1320

aacgtcgacg gaggaggagg gtctggagga gggggaagtg gcgggggagg cagcggggga     1380

ggcgggtctc tcgagagtgg ccaggtgctg ctggaaagca atatcaaggt cctgccaact     1440

tggtccaccc cagtgcagcc tatggctctg attgtgctgg gaggagtcgc aggactgctg     1500

ctgtttatcg gcctggggat tttcttttgc gtgcgctgcc ggcaccggag aaggcaggct     1560

gagcgcatgt ctcagattaa gcgactgctg agcgagaaga agacctgtca gtgcccccat     1620

agattccaga aaacctgttc acccatt                                         1647


<210>  4
<211>  549
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Glu Leu Gly Gly Gly Gly Ser Gly Ser Met Asp Ile Gln Met 
            20                  25                  30          


Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr 
        35                  40                  45              


Ile Ser Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr Leu Asn Trp Tyr 
    50                  55                  60                  


Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser 
65                  70                  75                  80  


Arg Leu His Ser Gly Val Pro Ser Lys Phe Ser Gly Ser Gly Ser Gly 
                85                  90                  95      


Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala 
            100                 105                 110         


Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp Thr Phe Ala Gly 
        115                 120                 125             


Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Gln 
145                 150                 155                 160 


Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Met Lys Ile Ser 
                165                 170                 175     


Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val 
            180                 185                 190         


Lys Gln Ser His Gly Lys Asn Leu Glu Trp Met Gly Leu Ile Asn Pro 
        195                 200                 205             


Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr 
    210                 215                 220                 


Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Leu Ser 
225                 230                 235                 240 


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr 
                245                 250                 255     


Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Thr 
            260                 265                 270         


Leu Thr Val Phe Ser Thr Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        275                 280                 285             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Met Ser Arg 
    290                 295                 300                 


Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
305                 310                 315                 320 


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
                325                 330                 335     


Lys Asp Glu Tyr Gly Leu Thr Pro Leu Tyr Leu Ala Thr Ala His Gly 
            340                 345                 350         


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
        355                 360                 365             


Ala Val Asp Ala Ile Gly Phe Thr Pro Leu His Leu Ala Ala Phe Ile 
    370                 375                 380                 


Gly His Leu Glu Ile Ala Glu Val Leu Leu Lys His Gly Ala Asp Val 
385                 390                 395                 400 


Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Gly 
                405                 410                 415     


Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu Asn Glu Gln 
            420                 425                 430         


Lys Leu Ile Ser Glu Glu Asp Leu Asn Val Asp Gly Gly Gly Gly Ser 
        435                 440                 445             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu 
    450                 455                 460                 


Glu Ser Gly Gln Val Leu Leu Glu Ser Asn Ile Lys Val Leu Pro Thr 
465                 470                 475                 480 


Trp Ser Thr Pro Val Gln Pro Met Ala Leu Ile Val Leu Gly Gly Val 
                485                 490                 495     


Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe Cys Val Arg 
            500                 505                 510         


Cys Arg His Arg Arg Arg Gln Ala Glu Arg Met Ser Gln Ile Lys Arg 
        515                 520                 525             


Leu Leu Ser Glu Lys Lys Thr Cys Gln Cys Pro His Arg Phe Gln Lys 
    530                 535                 540                 


Thr Cys Ser Pro Ile 
545                 


<210>  5
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5
atggatttcc aggtccagat tttctccttc ctgctgattt ccgcaagcgt catt             54


<210>  6
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile 
        


<210>  7
<211>  387
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7
atgtcacggg gctccgacct gggcaaaaag ctgctggagg ccgctagggc cgggcaggac       60

gatgaagtga gaatcctgat ggccaacggg gctgacgtga atgctaagga tgagtacggc      120

ctgacccccc tgtatctggc tacagcacac ggccatctgg agatcgtgga agtcctgctg      180

aaaaacggag ccgacgtgaa tgcagtcgat gccattgggt tcactcctct gcacctggca      240

gcctttatcg gacatctgga gattgcagaa gtgctgctga agcacggcgc tgacgtgaac      300

gcacaggata agttcggaaa aaccgctttt gacatcagca ttggcaacgg aaatgaagac      360

ctggctgaaa tcctgcagaa actgaat                                          387


<210>  8
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Met Ser Arg Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg 
1               5                   10                  15      


Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp 
            20                  25                  30          


Val Asn Ala Lys Asp Glu Tyr Gly Leu Thr Pro Leu Tyr Leu Ala Thr 
        35                  40                  45              


Ala His Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala 
    50                  55                  60                  


Asp Val Asn Ala Val Asp Ala Ile Gly Phe Thr Pro Leu His Leu Ala 
65                  70                  75                  80  


Ala Phe Ile Gly His Leu Glu Ile Ala Glu Val Leu Leu Lys His Gly 
                85                  90                  95      


Ala Asp Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile 
            100                 105                 110         


Ser Ile Gly Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu 
        115                 120                 125             


Asn 
    


<210>  9
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9
gaacagaaac tgattagcga agaagacctg                                        30


<210>  10
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  11
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11
aaccccgggg gaggaggagg gagcggggga ggaggcagcg gcgggggagg ctctggagga       60

ggagggagcg gatcc                                                        75


<210>  12
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12

Asn Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Gly Ser Gly Ser 
            20                  25  


<210>  13
<211>  750
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13
atggacatcc agatgactca gaccacaagc tccctgtctg caagtctggg cgaccgggtg       60

acaatctcct gcagagcctc tcaggatatt aggaactacc tgaattggta tcagcagaaa      120

cctgatggca cagtcaagct gctgatctac tataccagcc ggctgcactc aggcgtgcca      180

agcaaattct caggaagcgg ctccgggact gactactccc tgaccatctc taacctggag      240

caggaagata ttgctaccta tttctgccag cagggcaata cactgccctg gacttttgcc      300

ggaggcacca aactggagat caagggggga ggcgggagtg gaggcggggg atcaggagga      360

ggaggcagcg gaggaggagg gtccgaggtc cagctgcagc agagcggacc agaactggtg      420

aagcccggag caagtatgaa aatctcctgt aaggcctcag gatacagctt caccggctat      480

acaatgaact gggtgaaaca gtcccatggc aagaacctgg aatggatggg gctgattaat      540

ccttacaaag gcgtcagcac ctataatcag aagtttaaag acaaggccac actgactgtg      600

gataagtcta gttcaaccgc ttacatggag ctgctgtccc tgacatctga agacagtgcc      660

gtgtactatt gtgctcggtc tggctactat ggggacagtg attggtactt cgatgtctgg      720

ggacagggca ctaccctgac cgtgttttct                                       750


<210>  14
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14

Met Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Arg Asn 
            20                  25                  30          


Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Lys Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu 
65                  70                  75                  80  


Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro 
                85                  90                  95      


Trp Thr Phe Ala Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
    130                 135                 140                 


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
145                 150                 155                 160 


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Met 
                165                 170                 175     


Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe 
            180                 185                 190         


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
        195                 200                 205             


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
225                 230                 235                 240 


Gly Gln Gly Thr Thr Leu Thr Val Phe Ser 
                245                 250 


<210>  15
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15
actagtggcg gaggaggatc actcgag                                           27


<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16

Thr Ser Gly Gly Gly Gly Ser Leu Glu 
1               5                   


<210>  17
<211>  252
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17
agcggacagg tgctgctgga atccaatatc aaagtcctgc ccacttggtc tacccccgtg       60

cagcctatgg ctctgattgt gctgggagga gtcgcaggac tgctgctgtt tatcgggctg      120

ggaattttct tttgcgtgcg ctgccggcac cggagaaggc aggccgagcg catgagccag      180

atcaagcgac tgctgagcga gaagaaaacc tgtcagtgtc cccatagatt ccagaagacc      240

tgttcaccca tt                                                          252


<210>  18
<211>  84
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18

Ser Gly Gln Val Leu Leu Glu Ser Asn Ile Lys Val Leu Pro Thr Trp 
1               5                   10                  15      


Ser Thr Pro Val Gln Pro Met Ala Leu Ile Val Leu Gly Gly Val Ala 
            20                  25                  30          


Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe Cys Val Arg Cys 
        35                  40                  45              


Arg His Arg Arg Arg Gln Ala Glu Arg Met Ser Gln Ile Lys Arg Leu 
    50                  55                  60                  


Leu Ser Glu Lys Lys Thr Cys Gln Cys Pro His Arg Phe Gln Lys Thr 
65                  70                  75                  80  


Cys Ser Pro Ile 
                


<210>  19
<211>  56
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19

Gly Gly Gly Gly Ser Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15      


Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala Leu Glu Ala Glu Ala 
            20                  25                  30          


Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala 
        35                  40                  45              


Ala Lys Ala Gly Gly Gly Gly Ser 
    50                  55      


<210>  20
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20

Gly Gly Gly Gly Ser Ala Ala Leu Ser Pro Ser Pro Leu Ala Pro Gly 
1               5                   10                  15      


Pro Ala Ala Pro Ala Ala Leu Ala Pro Ala Pro Leu Ala Pro Gly Pro 
            20                  25                  30          


Ser Ala Pro Ala Ala Ala Ser Pro Ser Pro Leu Ala Pro Gly Pro Ser 
        35                  40                  45              


Ala Pro Gly Gly Gly Gly Ser 
    50                  55  


<210>  21
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21

Ser Gly Ala Val Leu Leu Ala Ser Ala Val Ala Val Leu Pro Ser Ala 
1               5                   10                  15      


Ser Ser Pro Val Ala Pro Ser Gly Ala Val Leu Leu Ala Ser Ala Val 
            20                  25                  30          


Ala Val Leu Pro Ser Ala Ser Ser Pro Val Ala Pro Ser Gly Ala Val 
        35                  40                  45              


Leu Leu Ala Ser Ala Val Ala Val Leu Pro Ser Ala Ser Ser Pro Val 
    50                  55                  60                  


Ala Pro 
65      


<210>  22
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22
atgtctagac aggtacaact gcagcagtca ggacctgaac tgaagaagcc tggagagaca       60

gtcaagatct cctgcaaggc ctctgggtat cctttcacaa actatggaat gaactgggtg      120

aagcaggctc caggacaggg tttaaagtgg atgggctgga ttaacacctc cactggagag      180

tcaacatttg ctgatgactt caagggacgg tttgacttct ctttggaaac ctctgccaac      240

actgcctatt tgcagatcaa caacctcaaa agtgaagaca tggctacata tttctgtgca      300

agatgggagg tttaccacgg ctacgttcct tactggggcc aagggaccac ggtcaccgtt      360

tcctctggcg gtggcggttc tggtggcggt ggctccggcg gtggcggttc tgacatccag      420

ctgacccagt ctcacaaatt cctgtccact tcagtaggag acagggtcag catcacctgc      480

aaggccagtc aggatgtgta taatgctgtt gcctggtatc aacagaaacc aggacaatct      540

cctaaacttc tgatttactc ggcatcctcc cggtacactg gagtcccttc tcgcttcact      600

ggcagtggct ctgggccgga tttcactttc accatcagca gtgtgcaggc tgaagacctg      660

gcagtttatt tctgtcagca acattttcgt actccattca cgttcggctc ggggacaaaa      720

ttggagatc                                                              729


<210>  23
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23

Met Ser Arg Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Lys Lys 
1               5                   10                  15      


Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Pro Phe 
            20                  25                  30          


Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu 
        35                  40                  45              


Lys Trp Met Gly Trp Ile Asn Thr Ser Thr Gly Glu Ser Thr Phe Ala 
    50                  55                  60                  


Asp Asp Phe Lys Gly Arg Phe Asp Phe Ser Leu Glu Thr Ser Ala Asn 
65                  70                  75                  80  


Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Ser Glu Asp Met Ala Thr 
                85                  90                  95      


Tyr Phe Cys Ala Arg Trp Glu Val Tyr His Gly Tyr Val Pro Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser 
    130                 135                 140                 


His Lys Phe Leu Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys 
145                 150                 155                 160 


Lys Ala Ser Gln Asp Val Tyr Asn Ala Val Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Arg Tyr 
            180                 185                 190         


Thr Gly Val Pro Ser Arg Phe Thr Gly Ser Gly Ser Gly Pro Asp Phe 
        195                 200                 205             


Thr Phe Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Phe 
    210                 215                 220                 


Cys Gln Gln His Phe Arg Thr Pro Phe Thr Phe Gly Ser Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile 
            


<210>  24
<211>  750
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24
atggacatcc agatgactca gaccacaagc tccctgtctg caagtctggg cgaccgggtg       60

acaatctcct gcagagcctc tcaggatatt aggaactacc tgaattggta tcagcagaaa      120

cctgatggca cagtcaagct gctgatctac tataccagcc ggctgcactc aggcgtgcca      180

agcaaattct caggaagcgg ctccgggact gactactccc tgaccatctc taacctggag      240

caggaagata ttgttaccta tttctgccag cagggcaata cactgccctg gacttttgcc      300

ggaggcacca aactggagat caagggggga ggcgggagtg gaggcggggg atcaggagga      360

ggaggcagcg gaggaggagg gtccgaggtc cagctgcagc agagcggacc agaactggtg      420

aagcccggag caagtatgaa aatctcctgt aaggcctcag gatacagctt caccggctat      480

ccgatgaact gggtgaaaca gtcccatggc aagaacctgg aatggatggg gctgattaat      540

ccttacaaag gcgtcagcac ctataatcag aagtttaaag acaaggccac actgactgtg      600

gataagtcta gttcaaccgc ttacatggag ctgctgtccc tgacatctga agacagtgcc      660

gtgtactatt gtgctcggtc tggctactat ggggacagtg attggtactt cgatgtctgg      720

ggacagggca ctaccctgac cgtgttttct                                       750


<210>  25
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25

Met Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Arg Asn 
            20                  25                  30          


Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Lys Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu 
65                  70                  75                  80  


Gln Glu Asp Ile Val Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro 
                85                  90                  95      


Trp Thr Phe Ala Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
    130                 135                 140                 


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
145                 150                 155                 160 


Pro Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Met 
                165                 170                 175     


Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe 
            180                 185                 190         


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
        195                 200                 205             


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
225                 230                 235                 240 


Gly Gln Gly Thr Thr Leu Thr Val Phe Ser 
                245                 250 


