                         SEQUENCE LISTING

<110>  CHIRIVA-INTERNATI, MAURIZIO
       FIGUEROA, JOSE A.
       COBOS, EVERARDO
 
<120>  GALECTIN-3 INHIBITOR (GAL-3M) IS ASSOCIATED WITH ADDITIVE 
       ANTI-MYELOMA AND ANTI-SOLID TUMOR EFFECTS, DECREASED 
       OSTEOCLASTOGENESIS AND ORGAN PROTECTION WHEN USED IN COMBINATION 
       WITH PROTEASOME INHIBITORS

<130>  TECH:2047WO

<140>  UNKNOWN
<141>  2015-02-03

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  744
<212>  DNA
<213>  Homo sapiens

<400>  1
gagtatttga ggctcggagc caccgccccg ccggcgcccg cagcacctcc tcgccagcag       60

ccgtccggag ccagccaacg agcggaaaat ggcagacaat ttttcgctcc atgatgcgtt      120

atctgggtct ggaaacccaa accctcaagg atggcctggc gcatggggga accagcctgc      180

tggggcaggg ggctacccag gggcttccta tcctggggcc taccccgggc aggcaccccc      240

aggggcttat cctggacagg cacctccagg cgcctaccct ggagcacctg gagcttatcc      300

cggagcacct gcacctggag tctacccagg gccacccagc ggccctgggg cctacccatc      360

ttctggacag ccaagtgcca ccggagccta ccctgccact ggcccctatg gcgcccctgc      420

tgggccactg attgtgcctt ataacctgcc tttgcctggg ggagtggtgc ctcgcatgct      480

gataacaatt ctgggcacgg tgaagcccaa tgcaaacaga attgctttag atttccaaag      540

agggaatgat gttgccttcc actttaaccc acgcttcaat gagaacaaca ggagagtcat      600

tgtttgcact tacatgtgta aaggtttcat gttcactgtg agtgaaaatt tttacattca      660

tcaatatccc tcttgtaagt catctactta ataaatatta cagtgaatta cctgtctcaa      720

tatgtcaaaa aaaaaaaaaa aaaa                                             744


<210>  2
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Asp Asn Phe Ser Leu His Asp Ala Leu Ser Gly Ser Gly Asn 
1               5                   10                  15      


Pro Asn Pro Gln Gly Trp Pro Gly Ala Trp Gly Asn Gln Pro Ala Gly 
            20                  25                  30          


Ala Gly Gly Tyr Pro Gly Ala Ser Tyr Pro Gly Ala Tyr Pro Gly Gln 
        35                  40                  45              


Ala Pro Pro Gly Ala Tyr Pro Gly Gln Ala Pro Pro Gly Ala Tyr Pro 
    50                  55                  60                  


Gly Ala Pro Gly Ala Tyr Pro Gly Ala Pro Ala Pro Gly Val Tyr Pro 
65                  70                  75                  80  


Gly Pro Pro Ser Gly Pro Gly Ala Tyr Pro Ser Ser Gly Gln Pro Ser 
                85                  90                  95      


Ala Thr Gly Ala Tyr Pro Ala Thr Gly Pro Tyr Gly Ala Pro Ala Gly 
            100                 105                 110         


Pro Leu Ile Val Pro Tyr Asn Leu Pro Leu Pro Gly Gly Val Val Pro 
        115                 120                 125             


Arg Met Leu Ile Thr Ile Leu Gly Thr Val Lys Pro Asn Ala Asn Arg 
    130                 135                 140                 


Ile Ala Leu Asp Phe Gln Arg Gly Asn Asp Val Ala Phe His Phe Asn 
145                 150                 155                 160 


Pro Arg Phe Asn Glu Asn Asn Arg Arg Val Ile Val Cys Asn Thr Lys 
                165                 170                 175     


Leu Asp Asn Asn Trp Gly Arg Glu Glu Arg Gln Ser Val Phe Pro Phe 
            180                 185                 190         


Glu Ser Gly Lys Pro Phe Lys Ile Gln Val Leu Val Glu Pro Asp His 
        195                 200                 205             


Phe Lys Val Ala Val Asn Asp Ala His Leu Leu Gln Tyr Asn His Arg 
    210                 215                 220                 


Val Lys Lys Leu Asn Glu Ile Ser Lys Leu Gly Ile Ser Gly Asp Ile 
225                 230                 235                 240 


Asp Leu Thr Ser Ala Ser Tyr Thr Met Ile 
                245                 250 


<210>  3
<211>  814
<212>  DNA
<213>  Homo sapiens

<400>  3
agcagccgtc cggagccagc caacgagcgg aaaatggcag acaatttttc gctccatgat       60

gcgttatctg ggtctggaaa cccaaaccct caaggatggc ctggcgcatg ggggaaccag      120

cctgctgggg cagggggcta cccaggggct tcctatcctg gggcctaccc cgggcaggca      180

cccccagggg cttatcctgg acaggcacct ccaggcgcct accatggagc acctggagct      240

tatcccggag cacctgcacc tggagtctac ccagggccac ccagcggccc tggggcctac      300

ccatcttctg gacagccaag tgcccccgga gcctaccctg ccactggccc ctatggcgcc      360

cctgctgggc cactgattgt gccttataac ctgcctttgc ctgggggagt ggtgcctcgc      420

atgctcataa caattctggg cacggtgaag cccaatgcaa acagaattgc tttagatttc      480

caaagaggga atgatgttgc cttccacttt aacccacgct tcaatgagaa caacaggaga      540

gtcattgttt gcaatacaaa gctggataat aactggggaa gggaagaaag acagtcggtt      600

ttcccatttg aaagtgggaa accattcaaa atacaagtac tggttgaacc tgaccacttc      660

aaggttgcag tgaatgatgc tcacttgttg cagtacaatc atcgggttaa aaaactcaat      720

gaaatcagca aactgggaat ttctggtgac atagacctca ccagtgcttc atataccatg      780

atataatctg aaaggggcag attaaaaaaa aaaa                                  814


<210>  4
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Asp Asn Phe Ser Leu His Asp Ala Leu Ser Gly Ser Gly Asn 
1               5                   10                  15      


Pro Asn Pro Gln Gly Trp Pro Gly Ala Trp Gly Asn Gln Pro Ala Gly 
            20                  25                  30          


Ala Gly Gly Tyr Pro Gly Ala Ser Tyr Pro Gly Ala Tyr Pro Gly Gln 
        35                  40                  45              


Ala Pro Pro Gly Ala Tyr Pro Gly Gln Ala Pro Pro Gly Ala Tyr His 
    50                  55                  60                  


Gly Ala Pro Gly Ala Tyr Pro Gly Ala Pro Ala Pro Gly Val Tyr Pro 
65                  70                  75                  80  


Gly Pro Pro Ser Gly Pro Gly Ala Tyr Pro Ser Ser Gly Gln Pro Ser 
                85                  90                  95      


Ala Pro Gly Ala Tyr Pro Ala Thr Gly Pro Tyr Gly Ala Pro Ala Gly 
            100                 105                 110         


Pro Leu Ile Val Pro Tyr Asn Leu Pro Leu Pro Gly Gly Val Val Pro 
        115                 120                 125             


Arg Met Leu Ile Thr Ile Leu Gly Thr Val Lys Pro Asn Ala Asn Arg 
    130                 135                 140                 


Ile Ala Leu Asp Phe Gln Arg Gly Asn Asp Val Ala Phe His Phe Asn 
145                 150                 155                 160 


Pro Arg Phe Asn Glu Asn Asn Arg Arg Val Ile Val Cys Asn Thr Lys 
                165                 170                 175     


Leu Asp Asn Asn Trp Gly Arg Glu Glu Arg Gln Ser Val Phe Pro Phe 
            180                 185                 190         


Glu Ser Gly Lys Pro Phe Lys Ile Gln Val Leu Val Glu Pro Asp His 
        195                 200                 205             


Phe Lys Val Ala Val Asn Asp Ala His Leu Leu Gln Tyr Asn His Arg 
    210                 215                 220                 


Val Lys Lys Leu Asn Glu Ile Ser Lys Leu Gly Ile Ser Gly Asp Ile 
225                 230                 235                 240 


Asp Leu Thr Ser Ala Ser Tyr Thr Met Ile 
                245                 250 


<210>  5
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  5
ggatccgcag tgattgtgcc taataacct                                         29


<210>  6
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  6
aagctttatc atggtatatg aagcactggt g                                      31


