                         SEQUENCE LISTING

<110>  biOasis Technologies, Inc.
       
 
<120>  P97 FUSION PROTEINS

<130>  BIOA-008/01WO

<150>  US 61/935,253
<151>  2014-02-03

<160>  138   

<170>  PatentIn version 3.5

<210>  1
<211>  738
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Gly Pro Ser Gly Ala Leu Trp Leu Leu Leu Ala Leu Arg Thr 
1               5                   10                  15      


Val Leu Gly Gly Met Glu Val Arg Trp Cys Ala Thr Ser Asp Pro Glu 
            20                  25                  30          


Gln His Lys Cys Gly Asn Met Ser Glu Ala Phe Arg Glu Ala Gly Ile 
        35                  40                  45              


Gln Pro Ser Leu Leu Cys Val Arg Gly Thr Ser Ala Asp His Cys Val 
    50                  55                  60                  


Gln Leu Ile Ala Ala Gln Glu Ala Asp Ala Ile Thr Leu Asp Gly Gly 
65                  70                  75                  80  


Ala Ile Tyr Glu Ala Gly Lys Glu His Gly Leu Lys Pro Val Val Gly 
                85                  90                  95      


Glu Val Tyr Asp Gln Glu Val Gly Thr Ser Tyr Tyr Ala Val Ala Val 
            100                 105                 110         


Val Arg Arg Ser Ser His Val Thr Ile Asp Thr Leu Lys Gly Val Lys 
        115                 120                 125             


Ser Cys His Thr Gly Ile Asn Arg Thr Val Gly Trp Asn Val Pro Val 
    130                 135                 140                 


Gly Tyr Leu Val Glu Ser Gly Arg Leu Ser Val Met Gly Cys Asp Val 
145                 150                 155                 160 


Leu Lys Ala Val Ser Asp Tyr Phe Gly Gly Ser Cys Val Pro Gly Ala 
                165                 170                 175     


Gly Glu Thr Ser Tyr Ser Glu Ser Leu Cys Arg Leu Cys Arg Gly Asp 
            180                 185                 190         


Ser Ser Gly Glu Gly Val Cys Asp Lys Ser Pro Leu Glu Arg Tyr Tyr 
        195                 200                 205             


Asp Tyr Ser Gly Ala Phe Arg Cys Leu Ala Glu Gly Ala Gly Asp Val 
    210                 215                 220                 


Ala Phe Val Lys His Ser Thr Val Leu Glu Asn Thr Asp Gly Lys Thr 
225                 230                 235                 240 


Leu Pro Ser Trp Gly Gln Ala Leu Leu Ser Gln Asp Phe Glu Leu Leu 
                245                 250                 255     


Cys Arg Asp Gly Ser Arg Ala Asp Val Thr Glu Trp Arg Gln Cys His 
            260                 265                 270         


Leu Ala Arg Val Pro Ala His Ala Val Val Val Arg Ala Asp Thr Asp 
        275                 280                 285             


Gly Gly Leu Ile Phe Arg Leu Leu Asn Glu Gly Gln Arg Leu Phe Ser 
    290                 295                 300                 


His Glu Gly Ser Ser Phe Gln Met Phe Ser Ser Glu Ala Tyr Gly Gln 
305                 310                 315                 320 


Lys Asp Leu Leu Phe Lys Asp Ser Thr Ser Glu Leu Val Pro Ile Ala 
                325                 330                 335     


Thr Gln Thr Tyr Glu Ala Trp Leu Gly His Glu Tyr Leu His Ala Met 
            340                 345                 350         


Lys Gly Leu Leu Cys Asp Pro Asn Arg Leu Pro Pro Tyr Leu Arg Trp 
        355                 360                 365             


Cys Val Leu Ser Thr Pro Glu Ile Gln Lys Cys Gly Asp Met Ala Val 
    370                 375                 380                 


Ala Phe Arg Arg Gln Arg Leu Lys Pro Glu Ile Gln Cys Val Ser Ala 
385                 390                 395                 400 


Lys Ser Pro Gln His Cys Met Glu Arg Ile Gln Ala Glu Gln Val Asp 
                405                 410                 415     


Ala Val Thr Leu Ser Gly Glu Asp Ile Tyr Thr Ala Gly Lys Thr Tyr 
            420                 425                 430         


Gly Leu Val Pro Ala Ala Gly Glu His Tyr Ala Pro Glu Asp Ser Ser 
        435                 440                 445             


Asn Ser Tyr Tyr Val Val Ala Val Val Arg Arg Asp Ser Ser His Ala 
    450                 455                 460                 


Phe Thr Leu Asp Glu Leu Arg Gly Lys Arg Ser Cys His Ala Gly Phe 
465                 470                 475                 480 


Gly Ser Pro Ala Gly Trp Asp Val Pro Val Gly Ala Leu Ile Gln Arg 
                485                 490                 495     


Gly Phe Ile Arg Pro Lys Asp Cys Asp Val Leu Thr Ala Val Ser Glu 
            500                 505                 510         


Phe Phe Asn Ala Ser Cys Val Pro Val Asn Asn Pro Lys Asn Tyr Pro 
        515                 520                 525             


Ser Ser Leu Cys Ala Leu Cys Val Gly Asp Glu Gln Gly Arg Asn Lys 
    530                 535                 540                 


Cys Val Gly Asn Ser Gln Glu Arg Tyr Tyr Gly Tyr Arg Gly Ala Phe 
545                 550                 555                 560 


Arg Cys Leu Val Glu Asn Ala Gly Asp Val Ala Phe Val Arg His Thr 
                565                 570                 575     


Thr Val Phe Asp Asn Thr Asn Gly His Asn Ser Glu Pro Trp Ala Ala 
            580                 585                 590         


Glu Leu Arg Ser Glu Asp Tyr Glu Leu Leu Cys Pro Asn Gly Ala Arg 
        595                 600                 605             


Ala Glu Val Ser Gln Phe Ala Ala Cys Asn Leu Ala Gln Ile Pro Pro 
    610                 615                 620                 


His Ala Val Met Val Arg Pro Asp Thr Asn Ile Phe Thr Val Tyr Gly 
625                 630                 635                 640 


Leu Leu Asp Lys Ala Gln Asp Leu Phe Gly Asp Asp His Asn Lys Asn 
                645                 650                 655     


Gly Phe Lys Met Phe Asp Ser Ser Asn Tyr His Gly Gln Asp Leu Leu 
            660                 665                 670         


Phe Lys Asp Ala Thr Val Arg Ala Val Pro Val Gly Glu Lys Thr Thr 
        675                 680                 685             


Tyr Arg Gly Trp Leu Gly Leu Asp Tyr Val Ala Ala Leu Glu Gly Met 
    690                 695                 700                 


Ser Ser Gln Gln Cys Ser Gly Ala Ala Ala Pro Ala Pro Gly Ala Pro 
705                 710                 715                 720 


Leu Leu Pro Leu Leu Leu Pro Ala Leu Ala Ala Arg Leu Leu Pro Pro 
                725                 730                 735     


Ala Leu 
        


<210>  2
<211>  692
<212>  PRT
<213>  Homo sapiens

<400>  2

Gly Met Glu Val Arg Trp Cys Ala Thr Ser Asp Pro Glu Gln His Lys 
1               5                   10                  15      


Cys Gly Asn Met Ser Glu Ala Phe Arg Glu Ala Gly Ile Gln Pro Ser 
            20                  25                  30          


Leu Leu Cys Val Arg Gly Thr Ser Ala Asp His Cys Val Gln Leu Ile 
        35                  40                  45              


Ala Ala Gln Glu Ala Asp Ala Ile Thr Leu Asp Gly Gly Ala Ile Tyr 
    50                  55                  60                  


Glu Ala Gly Lys Glu His Gly Leu Lys Pro Val Val Gly Glu Val Tyr 
65                  70                  75                  80  


Asp Gln Glu Val Gly Thr Ser Tyr Tyr Ala Val Ala Val Val Arg Arg 
                85                  90                  95      


Ser Ser His Val Thr Ile Asp Thr Leu Lys Gly Val Lys Ser Cys His 
            100                 105                 110         


Thr Gly Ile Asn Arg Thr Val Gly Trp Asn Val Pro Val Gly Tyr Leu 
        115                 120                 125             


Val Glu Ser Gly Arg Leu Ser Val Met Gly Cys Asp Val Leu Lys Ala 
    130                 135                 140                 


Val Ser Asp Tyr Phe Gly Gly Ser Cys Val Pro Gly Ala Gly Glu Thr 
145                 150                 155                 160 


Ser Tyr Ser Glu Ser Leu Cys Arg Leu Cys Arg Gly Asp Ser Ser Gly 
                165                 170                 175     


Glu Gly Val Cys Asp Lys Ser Pro Leu Glu Arg Tyr Tyr Asp Tyr Ser 
            180                 185                 190         


Gly Ala Phe Arg Cys Leu Ala Glu Gly Ala Gly Asp Val Ala Phe Val 
        195                 200                 205             


Lys His Ser Thr Val Leu Glu Asn Thr Asp Gly Lys Thr Leu Pro Ser 
    210                 215                 220                 


Trp Gly Gln Ala Leu Leu Ser Gln Asp Phe Glu Leu Leu Cys Arg Asp 
225                 230                 235                 240 


Gly Ser Arg Ala Asp Val Thr Glu Trp Arg Gln Cys His Leu Ala Arg 
                245                 250                 255     


Val Pro Ala His Ala Val Val Val Arg Ala Asp Thr Asp Gly Gly Leu 
            260                 265                 270         


Ile Phe Arg Leu Leu Asn Glu Gly Gln Arg Leu Phe Ser His Glu Gly 
        275                 280                 285             


Ser Ser Phe Gln Met Phe Ser Ser Glu Ala Tyr Gly Gln Lys Asp Leu 
    290                 295                 300                 


Leu Phe Lys Asp Ser Thr Ser Glu Leu Val Pro Ile Ala Thr Gln Thr 
305                 310                 315                 320 


Tyr Glu Ala Trp Leu Gly His Glu Tyr Leu His Ala Met Lys Gly Leu 
                325                 330                 335     


Leu Cys Asp Pro Asn Arg Leu Pro Pro Tyr Leu Arg Trp Cys Val Leu 
            340                 345                 350         


Ser Thr Pro Glu Ile Gln Lys Cys Gly Asp Met Ala Val Ala Phe Arg 
        355                 360                 365             


Arg Gln Arg Leu Lys Pro Glu Ile Gln Cys Val Ser Ala Lys Ser Pro 
    370                 375                 380                 


Gln His Cys Met Glu Arg Ile Gln Ala Glu Gln Val Asp Ala Val Thr 
385                 390                 395                 400 


Leu Ser Gly Glu Asp Ile Tyr Thr Ala Gly Lys Thr Tyr Gly Leu Val 
                405                 410                 415     


Pro Ala Ala Gly Glu His Tyr Ala Pro Glu Asp Ser Ser Asn Ser Tyr 
            420                 425                 430         


Tyr Val Val Ala Val Val Arg Arg Asp Ser Ser His Ala Phe Thr Leu 
        435                 440                 445             


Asp Glu Leu Arg Gly Lys Arg Ser Cys His Ala Gly Phe Gly Ser Pro 
    450                 455                 460                 


Ala Gly Trp Asp Val Pro Val Gly Ala Leu Ile Gln Arg Gly Phe Ile 
465                 470                 475                 480 


Arg Pro Lys Asp Cys Asp Val Leu Thr Ala Val Ser Glu Phe Phe Asn 
                485                 490                 495     


Ala Ser Cys Val Pro Val Asn Asn Pro Lys Asn Tyr Pro Ser Ser Leu 
            500                 505                 510         


Cys Ala Leu Cys Val Gly Asp Glu Gln Gly Arg Asn Lys Cys Val Gly 
        515                 520                 525             


Asn Ser Gln Glu Arg Tyr Tyr Gly Tyr Arg Gly Ala Phe Arg Cys Leu 
    530                 535                 540                 


Val Glu Asn Ala Gly Asp Val Ala Phe Val Arg His Thr Thr Val Phe 
545                 550                 555                 560 


Asp Asn Thr Asn Gly His Asn Ser Glu Pro Trp Ala Ala Glu Leu Arg 
                565                 570                 575     


Ser Glu Asp Tyr Glu Leu Leu Cys Pro Asn Gly Ala Arg Ala Glu Val 
            580                 585                 590         


Ser Gln Phe Ala Ala Cys Asn Leu Ala Gln Ile Pro Pro His Ala Val 
        595                 600                 605             


Met Val Arg Pro Asp Thr Asn Ile Phe Thr Val Tyr Gly Leu Leu Asp 
    610                 615                 620                 


Lys Ala Gln Asp Leu Phe Gly Asp Asp His Asn Lys Asn Gly Phe Lys 
625                 630                 635                 640 


Met Phe Asp Ser Ser Asn Tyr His Gly Gln Asp Leu Leu Phe Lys Asp 
                645                 650                 655     


Ala Thr Val Arg Ala Val Pro Val Gly Glu Lys Thr Thr Tyr Arg Gly 
            660                 665                 670         


Trp Leu Gly Leu Asp Tyr Val Ala Ala Leu Glu Gly Met Ser Ser Gln 
        675                 680                 685             


Gln Cys Ser Gly 
    690         


<210>  3
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  3

Trp Cys Ala Thr Ser Asp Pro Glu Gln His Lys 
1               5                   10      


<210>  4
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  4

Arg Ser Ser His Val Thr Ile Asp Thr Leu Lys 
1               5                   10      


<210>  5
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  5

Ser Ser His Val Thr Ile Asp Thr Leu Lys Gly Val Lys 
1               5                   10              


<210>  6
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  6

Leu Cys Arg Gly Asp Ser Ser Gly Glu Gly Val Cys Asp Lys 
1               5                   10                  


<210>  7
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  7

Gly Asp Ser Ser Gly Glu Gly Val Cys Asp Lys Ser Pro Leu Glu Arg 
1               5                   10                  15      


<210>  8
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  8

Tyr Tyr Asp Tyr Ser Gly Ala Phe Arg 
1               5                   


<210>  9
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  9

Ala Asp Val Thr Glu Trp Arg 
1               5           


<210>  10
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  10

Val Pro Ala His Ala Val Val Val Arg 
1               5                   


<210>  11
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  11

Ala Asp Thr Asp Gly Gly Leu Ile Phe Arg 
1               5                   10  


<210>  12
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  12

Cys Gly Asp Met Ala Val Ala Phe Arg 
1               5                   


<210>  13
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  13

Leu Lys Pro Glu Ile Gln Cys Val Ser Ala Lys 
1               5                   10      


<210>  14
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  14

Asp Ser Ser His Ala Phe Thr Leu Asp Glu Leu Arg 
1               5                   10          


<210>  15
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  15

Ser Glu Asp Tyr Glu Leu Leu Cys Pro Asn Gly Ala Arg 
1               5                   10              


<210>  16
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  16

Ala Gln Asp Leu Phe Gly Asp Asp His Asn Lys Asn Gly Phe Lys 
1               5                   10                  15  


<210>  17
<211>  40
<212>  PRT
<213>  Homo sapiens

<400>  17

Phe Ser Ser Glu Ala Tyr Gly Gln Lys Asp Leu Leu Phe Lys Asp Ser 
1               5                   10                  15      


Thr Ser Glu Leu Val Pro Ile Ala Thr Gln Thr Tyr Glu Ala Trp Leu 
            20                  25                  30          


Gly His Glu Tyr Leu His Ala Met 
        35                  40  


<210>  18
<211>  221
<212>  PRT
<213>  Homo sapiens

<400>  18

Glu Arg Ile Gln Ala Glu Gln Val Asp Ala Val Thr Leu Ser Gly Glu 
1               5                   10                  15      


Asp Ile Tyr Thr Ala Gly Lys Thr Tyr Gly Leu Val Pro Ala Ala Gly 
            20                  25                  30          


Glu His Tyr Ala Pro Glu Asp Ser Ser Asn Ser Tyr Tyr Val Val Ala 
        35                  40                  45              


Val Val Arg Arg Asp Ser Ser His Ala Phe Thr Leu Asp Glu Leu Arg 
    50                  55                  60                  


Gly Lys Arg Ser Cys His Ala Gly Phe Gly Ser Pro Ala Gly Trp Asp 
65                  70                  75                  80  


Val Pro Val Gly Ala Leu Ile Gln Arg Gly Phe Ile Arg Pro Lys Asp 
                85                  90                  95      


Cys Asp Val Leu Thr Ala Val Ser Glu Phe Phe Asn Ala Ser Cys Val 
            100                 105                 110         


Pro Val Asn Asn Pro Lys Asn Tyr Pro Ser Ser Leu Cys Ala Leu Cys 
        115                 120                 125             


Val Gly Asp Glu Gln Gly Arg Asn Lys Cys Val Gly Asn Ser Gln Glu 
    130                 135                 140                 


Arg Tyr Tyr Gly Tyr Arg Gly Ala Phe Arg Cys Leu Val Glu Asn Ala 
145                 150                 155                 160 


Gly Asp Val Ala Phe Val Arg His Thr Thr Val Phe Asp Asn Thr Asn 
                165                 170                 175     


Gly His Asn Ser Glu Pro Trp Ala Ala Glu Leu Arg Ser Glu Asp Tyr 
            180                 185                 190         


Glu Leu Leu Cys Pro Asn Gly Ala Arg Ala Glu Val Ser Gln Phe Ala 
        195                 200                 205             


Ala Cys Asn Leu Ala Gln Ile Pro Pro His Ala Val Met 
    210                 215                 220     


<210>  19
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  19

Val Arg Pro Asp Thr Asn Ile Phe Thr Val Tyr Gly Leu Leu Asp Lys 
1               5                   10                  15      


Ala Gln Asp Leu Phe Gly Asp Asp His Asn Lys Asn Gly Phe Lys Met 
            20                  25                  30          


<210>  20
<211>  564
<212>  PRT
<213>  Homo sapiens

<400>  20

Gly Met Glu Val Arg Trp Cys Ala Thr Ser Asp Pro Glu Gln His Lys 
1               5                   10                  15      


Cys Gly Asn Met Ser Glu Ala Phe Arg Glu Ala Gly Ile Gln Pro Ser 
            20                  25                  30          


Leu Leu Cys Val Arg Gly Thr Ser Ala Asp His Cys Val Gln Leu Ile 
        35                  40                  45              


Ala Ala Gln Glu Ala Asp Ala Ile Thr Leu Asp Gly Gly Ala Ile Tyr 
    50                  55                  60                  


Glu Ala Gly Lys Glu His Gly Leu Lys Pro Val Val Gly Glu Val Tyr 
65                  70                  75                  80  


Asp Gln Glu Val Gly Thr Ser Tyr Tyr Ala Val Ala Val Val Arg Arg 
                85                  90                  95      


Ser Ser His Val Thr Ile Asp Thr Leu Lys Gly Val Lys Ser Cys His 
            100                 105                 110         


Thr Gly Ile Asn Arg Thr Val Gly Trp Asn Val Pro Val Gly Tyr Leu 
        115                 120                 125             


Val Glu Ser Gly Arg Leu Ser Val Met Gly Cys Asp Val Leu Lys Ala 
    130                 135                 140                 


Val Ser Asp Tyr Phe Gly Gly Ser Cys Val Pro Gly Ala Gly Glu Thr 
145                 150                 155                 160 


Ser Tyr Ser Glu Ser Leu Cys Arg Leu Cys Arg Gly Asp Ser Ser Gly 
                165                 170                 175     


Glu Gly Val Cys Asp Lys Ser Pro Leu Glu Arg Tyr Tyr Asp Tyr Ser 
            180                 185                 190         


Gly Ala Phe Arg Cys Leu Ala Glu Gly Ala Gly Asp Val Ala Phe Val 
        195                 200                 205             


Lys His Ser Thr Val Leu Glu Asn Thr Asp Gly Lys Thr Leu Pro Ser 
    210                 215                 220                 


Trp Gly Gln Ala Leu Leu Ser Gln Asp Phe Glu Leu Leu Cys Arg Asp 
225                 230                 235                 240 


Gly Ser Arg Ala Asp Val Thr Glu Trp Arg Gln Cys His Leu Ala Arg 
                245                 250                 255     


Val Pro Ala His Ala Val Val Val Arg Ala Asp Thr Asp Gly Gly Leu 
            260                 265                 270         


Ile Phe Arg Leu Leu Asn Glu Gly Gln Arg Leu Phe Ser His Glu Gly 
        275                 280                 285             


Ser Ser Phe Gln Met Phe Ser Ser Glu Ala Tyr Gly Gln Lys Asp Leu 
    290                 295                 300                 


Leu Phe Lys Asp Ser Thr Ser Glu Leu Val Pro Ile Ala Thr Gln Thr 
305                 310                 315                 320 


Tyr Glu Ala Trp Leu Gly His Glu Tyr Leu His Ala Met Lys Gly Leu 
                325                 330                 335     


Leu Cys Asp Pro Asn Arg Leu Pro Pro Tyr Leu Arg Trp Cys Val Leu 
            340                 345                 350         


Ser Thr Pro Glu Ile Gln Lys Cys Gly Asp Met Ala Val Ala Phe Arg 
        355                 360                 365             


Arg Gln Arg Leu Lys Pro Glu Ile Gln Cys Val Ser Ala Lys Ser Pro 
    370                 375                 380                 


Gln His Cys Met Glu Arg Ile Gln Ala Glu Gln Val Asp Ala Val Thr 
385                 390                 395                 400 


Leu Ser Gly Glu Asp Ile Tyr Thr Ala Gly Lys Thr Tyr Gly Leu Val 
                405                 410                 415     


Pro Ala Ala Gly Glu His Tyr Ala Pro Glu Asp Ser Ser Asn Ser Tyr 
            420                 425                 430         


Tyr Val Val Ala Val Val Arg Arg Asp Ser Ser His Ala Phe Thr Leu 
        435                 440                 445             


Asp Glu Leu Arg Gly Lys Arg Ser Cys His Ala Gly Phe Gly Ser Pro 
    450                 455                 460                 


Ala Gly Trp Asp Val Pro Val Gly Ala Leu Ile Gln Arg Gly Phe Ile 
465                 470                 475                 480 


Arg Pro Lys Asp Cys Asp Val Leu Thr Ala Val Ser Glu Phe Phe Asn 
                485                 490                 495     


Ala Ser Cys Val Pro Val Asn Asn Pro Lys Asn Tyr Pro Ser Ser Leu 
            500                 505                 510         


Cys Ala Leu Cys Val Gly Asp Glu Gln Gly Arg Asn Lys Cys Val Gly 
        515                 520                 525             


Asn Ser Gln Glu Arg Tyr Tyr Gly Tyr Arg Gly Ala Phe Arg Cys Leu 
    530                 535                 540                 


Val Glu Asn Ala Gly Asp Val Ala Phe Val Arg His Thr Thr Val Phe 
545                 550                 555                 560 


Asp Asn Thr Asn 
                


<210>  21
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  21

Gly His Asn Ser Glu Pro Trp Ala Ala Glu Leu Arg Ser Glu Asp Tyr 
1               5                   10                  15      


Glu Leu Leu Cys Pro Asn 
            20          


<210>  22
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  22

Gly Ala Arg Ala Glu Val Ser Gln Phe Ala Ala Cys Asn Leu Ala Gln 
1               5                   10                  15      


Ile Pro Pro His Ala Val Met Val Arg Pro Asp Thr Asn Ile Phe Thr 
            20                  25                  30          


Val Tyr Gly Leu Leu Asp Lys Ala Gln Asp Leu Phe Gly Asp Asp His 
        35                  40                  45              


Asn Lys Asn 
    50      


<210>  23
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  23

Gly Phe Lys Met Phe Asp Ser Ser Asn Tyr His Gly Gln Asp Leu Leu 
1               5                   10                  15      


Phe Lys Asp Ala Thr Val Arg Ala Val Pro Val Gly Glu Lys Thr Thr 
            20                  25                  30          


Tyr Arg Gly Trp Leu Gly Leu Asp Tyr Val Ala Ala Leu Glu Gly Met 
        35                  40                  45              


Ser Ser Gln Gln Cys 
    50              


<210>  24
<211>  586
<212>  PRT
<213>  Homo sapiens

<400>  24

Gly Met Glu Val Arg Trp Cys Ala Thr Ser Asp Pro Glu Gln His Lys 
1               5                   10                  15      


Cys Gly Asn Met Ser Glu Ala Phe Arg Glu Ala Gly Ile Gln Pro Ser 
            20                  25                  30          


Leu Leu Cys Val Arg Gly Thr Ser Ala Asp His Cys Val Gln Leu Ile 
        35                  40                  45              


Ala Ala Gln Glu Ala Asp Ala Ile Thr Leu Asp Gly Gly Ala Ile Tyr 
    50                  55                  60                  


Glu Ala Gly Lys Glu His Gly Leu Lys Pro Val Val Gly Glu Val Tyr 
65                  70                  75                  80  


Asp Gln Glu Val Gly Thr Ser Tyr Tyr Ala Val Ala Val Val Arg Arg 
                85                  90                  95      


Ser Ser His Val Thr Ile Asp Thr Leu Lys Gly Val Lys Ser Cys His 
            100                 105                 110         


Thr Gly Ile Asn Arg Thr Val Gly Trp Asn Val Pro Val Gly Tyr Leu 
        115                 120                 125             


Val Glu Ser Gly Arg Leu Ser Val Met Gly Cys Asp Val Leu Lys Ala 
    130                 135                 140                 


Val Ser Asp Tyr Phe Gly Gly Ser Cys Val Pro Gly Ala Gly Glu Thr 
145                 150                 155                 160 


Ser Tyr Ser Glu Ser Leu Cys Arg Leu Cys Arg Gly Asp Ser Ser Gly 
                165                 170                 175     


Glu Gly Val Cys Asp Lys Ser Pro Leu Glu Arg Tyr Tyr Asp Tyr Ser 
            180                 185                 190         


Gly Ala Phe Arg Cys Leu Ala Glu Gly Ala Gly Asp Val Ala Phe Val 
        195                 200                 205             


Lys His Ser Thr Val Leu Glu Asn Thr Asp Gly Lys Thr Leu Pro Ser 
    210                 215                 220                 


Trp Gly Gln Ala Leu Leu Ser Gln Asp Phe Glu Leu Leu Cys Arg Asp 
225                 230                 235                 240 


Gly Ser Arg Ala Asp Val Thr Glu Trp Arg Gln Cys His Leu Ala Arg 
                245                 250                 255     


Val Pro Ala His Ala Val Val Val Arg Ala Asp Thr Asp Gly Gly Leu 
            260                 265                 270         


Ile Phe Arg Leu Leu Asn Glu Gly Gln Arg Leu Phe Ser His Glu Gly 
        275                 280                 285             


Ser Ser Phe Gln Met Phe Ser Ser Glu Ala Tyr Gly Gln Lys Asp Leu 
    290                 295                 300                 


Leu Phe Lys Asp Ser Thr Ser Glu Leu Val Pro Ile Ala Thr Gln Thr 
305                 310                 315                 320 


Tyr Glu Ala Trp Leu Gly His Glu Tyr Leu His Ala Met Lys Gly Leu 
                325                 330                 335     


Leu Cys Asp Pro Asn Arg Leu Pro Pro Tyr Leu Arg Trp Cys Val Leu 
            340                 345                 350         


Ser Thr Pro Glu Ile Gln Lys Cys Gly Asp Met Ala Val Ala Phe Arg 
        355                 360                 365             


Arg Gln Arg Leu Lys Pro Glu Ile Gln Cys Val Ser Ala Lys Ser Pro 
    370                 375                 380                 


Gln His Cys Met Glu Arg Ile Gln Ala Glu Gln Val Asp Ala Val Thr 
385                 390                 395                 400 


Leu Ser Gly Glu Asp Ile Tyr Thr Ala Gly Lys Thr Tyr Gly Leu Val 
                405                 410                 415     


Pro Ala Ala Gly Glu His Tyr Ala Pro Glu Asp Ser Ser Asn Ser Tyr 
            420                 425                 430         


Tyr Val Val Ala Val Val Arg Arg Asp Ser Ser His Ala Phe Thr Leu 
        435                 440                 445             


Asp Glu Leu Arg Gly Lys Arg Ser Cys His Ala Gly Phe Gly Ser Pro 
    450                 455                 460                 


Ala Gly Trp Asp Val Pro Val Gly Ala Leu Ile Gln Arg Gly Phe Ile 
465                 470                 475                 480 


Arg Pro Lys Asp Cys Asp Val Leu Thr Ala Val Ser Glu Phe Phe Asn 
                485                 490                 495     


Ala Ser Cys Val Pro Val Asn Asn Pro Lys Asn Tyr Pro Ser Ser Leu 
            500                 505                 510         


Cys Ala Leu Cys Val Gly Asp Glu Gln Gly Arg Asn Lys Cys Val Gly 
        515                 520                 525             


Asn Ser Gln Glu Arg Tyr Tyr Gly Tyr Arg Gly Ala Phe Arg Cys Leu 
    530                 535                 540                 


Val Glu Asn Ala Gly Asp Val Ala Phe Val Arg His Thr Thr Val Phe 
545                 550                 555                 560 


Asp Asn Thr Asn Gly His Asn Ser Glu Pro Trp Ala Ala Glu Leu Arg 
                565                 570                 575     


Ser Glu Asp Tyr Glu Leu Leu Cys Pro Asn 
            580                 585     


<210>  25
<211>  637
<212>  PRT
<213>  Homo sapiens

<400>  25

Gly Met Glu Val Arg Trp Cys Ala Thr Ser Asp Pro Glu Gln His Lys 
1               5                   10                  15      


Cys Gly Asn Met Ser Glu Ala Phe Arg Glu Ala Gly Ile Gln Pro Ser 
            20                  25                  30          


Leu Leu Cys Val Arg Gly Thr Ser Ala Asp His Cys Val Gln Leu Ile 
        35                  40                  45              


Ala Ala Gln Glu Ala Asp Ala Ile Thr Leu Asp Gly Gly Ala Ile Tyr 
    50                  55                  60                  


Glu Ala Gly Lys Glu His Gly Leu Lys Pro Val Val Gly Glu Val Tyr 
65                  70                  75                  80  


Asp Gln Glu Val Gly Thr Ser Tyr Tyr Ala Val Ala Val Val Arg Arg 
                85                  90                  95      


Ser Ser His Val Thr Ile Asp Thr Leu Lys Gly Val Lys Ser Cys His 
            100                 105                 110         


Thr Gly Ile Asn Arg Thr Val Gly Trp Asn Val Pro Val Gly Tyr Leu 
        115                 120                 125             


Val Glu Ser Gly Arg Leu Ser Val Met Gly Cys Asp Val Leu Lys Ala 
    130                 135                 140                 


Val Ser Asp Tyr Phe Gly Gly Ser Cys Val Pro Gly Ala Gly Glu Thr 
145                 150                 155                 160 


Ser Tyr Ser Glu Ser Leu Cys Arg Leu Cys Arg Gly Asp Ser Ser Gly 
                165                 170                 175     


Glu Gly Val Cys Asp Lys Ser Pro Leu Glu Arg Tyr Tyr Asp Tyr Ser 
            180                 185                 190         


Gly Ala Phe Arg Cys Leu Ala Glu Gly Ala Gly Asp Val Ala Phe Val 
        195                 200                 205             


Lys His Ser Thr Val Leu Glu Asn Thr Asp Gly Lys Thr Leu Pro Ser 
    210                 215                 220                 


Trp Gly Gln Ala Leu Leu Ser Gln Asp Phe Glu Leu Leu Cys Arg Asp 
225                 230                 235                 240 


Gly Ser Arg Ala Asp Val Thr Glu Trp Arg Gln Cys His Leu Ala Arg 
                245                 250                 255     


Val Pro Ala His Ala Val Val Val Arg Ala Asp Thr Asp Gly Gly Leu 
            260                 265                 270         


Ile Phe Arg Leu Leu Asn Glu Gly Gln Arg Leu Phe Ser His Glu Gly 
        275                 280                 285             


Ser Ser Phe Gln Met Phe Ser Ser Glu Ala Tyr Gly Gln Lys Asp Leu 
    290                 295                 300                 


Leu Phe Lys Asp Ser Thr Ser Glu Leu Val Pro Ile Ala Thr Gln Thr 
305                 310                 315                 320 


Tyr Glu Ala Trp Leu Gly His Glu Tyr Leu His Ala Met Lys Gly Leu 
                325                 330                 335     


Leu Cys Asp Pro Asn Arg Leu Pro Pro Tyr Leu Arg Trp Cys Val Leu 
            340                 345                 350         


Ser Thr Pro Glu Ile Gln Lys Cys Gly Asp Met Ala Val Ala Phe Arg 
        355                 360                 365             


Arg Gln Arg Leu Lys Pro Glu Ile Gln Cys Val Ser Ala Lys Ser Pro 
    370                 375                 380                 


Gln His Cys Met Glu Arg Ile Gln Ala Glu Gln Val Asp Ala Val Thr 
385                 390                 395                 400 


Leu Ser Gly Glu Asp Ile Tyr Thr Ala Gly Lys Thr Tyr Gly Leu Val 
                405                 410                 415     


Pro Ala Ala Gly Glu His Tyr Ala Pro Glu Asp Ser Ser Asn Ser Tyr 
            420                 425                 430         


Tyr Val Val Ala Val Val Arg Arg Asp Ser Ser His Ala Phe Thr Leu 
        435                 440                 445             


Asp Glu Leu Arg Gly Lys Arg Ser Cys His Ala Gly Phe Gly Ser Pro 
    450                 455                 460                 


Ala Gly Trp Asp Val Pro Val Gly Ala Leu Ile Gln Arg Gly Phe Ile 
465                 470                 475                 480 


Arg Pro Lys Asp Cys Asp Val Leu Thr Ala Val Ser Glu Phe Phe Asn 
                485                 490                 495     


Ala Ser Cys Val Pro Val Asn Asn Pro Lys Asn Tyr Pro Ser Ser Leu 
            500                 505                 510         


Cys Ala Leu Cys Val Gly Asp Glu Gln Gly Arg Asn Lys Cys Val Gly 
        515                 520                 525             


Asn Ser Gln Glu Arg Tyr Tyr Gly Tyr Arg Gly Ala Phe Arg Cys Leu 
    530                 535                 540                 


Val Glu Asn Ala Gly Asp Val Ala Phe Val Arg His Thr Thr Val Phe 
545                 550                 555                 560 


Asp Asn Thr Asn Gly His Asn Ser Glu Pro Trp Ala Ala Glu Leu Arg 
                565                 570                 575     


Ser Glu Asp Tyr Glu Leu Leu Cys Pro Asn Gly Ala Arg Ala Glu Val 
            580                 585                 590         


Ser Gln Phe Ala Ala Cys Asn Leu Ala Gln Ile Pro Pro His Ala Val 
        595                 600                 605             


Met Val Arg Pro Asp Thr Asn Ile Phe Thr Val Tyr Gly Leu Leu Asp 
    610                 615                 620                 


Lys Ala Gln Asp Leu Phe Gly Asp Asp His Asn Lys Asn 
625                 630                 635         


<210>  26
<211>  73
<212>  PRT
<213>  Homo sapiens

<400>  26

Gly His Asn Ser Glu Pro Trp Ala Ala Glu Leu Arg Ser Glu Asp Tyr 
1               5                   10                  15      


Glu Leu Leu Cys Pro Asn Gly Ala Arg Ala Glu Val Ser Gln Phe Ala 
            20                  25                  30          


Ala Cys Asn Leu Ala Gln Ile Pro Pro His Ala Val Met Val Arg Pro 
        35                  40                  45              


Asp Thr Asn Ile Phe Thr Val Tyr Gly Leu Leu Asp Lys Ala Gln Asp 
    50                  55                  60                  


Leu Phe Gly Asp Asp His Asn Lys Asn 
65                  70              


<210>  27
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  27

Gly His Asn Ser Glu Pro Trp Ala Ala Glu Leu Arg Ser Glu Asp Tyr 
1               5                   10                  15      


Glu Leu Leu Cys Pro Asn Gly Ala Arg Ala Glu Val Ser Gln Phe Ala 
            20                  25                  30          


Ala Cys Asn Leu Ala Gln Ile Pro Pro His Ala Val Met Val Arg Pro 
        35                  40                  45              


Asp Thr Asn Ile Phe Thr Val Tyr Gly Leu Leu Asp Lys Ala Gln Asp 
    50                  55                  60                  


Leu Phe Gly Asp Asp His Asn Lys Asn Gly Phe Lys Met Phe Asp Ser 
65                  70                  75                  80  


Ser Asn Tyr His Gly Gln Asp Leu Leu Phe Lys Asp Ala Thr Val Arg 
                85                  90                  95      


Ala Val Pro Val Gly Glu Lys Thr Thr Tyr Arg Gly Trp Leu Gly Leu 
            100                 105                 110         


Asp Tyr Val Ala Ala Leu Glu Gly Met Ser Ser Gln Gln Cys 
        115                 120                 125     


<210>  28
<211>  104
<212>  PRT
<213>  Homo sapiens

<400>  28

Gly Ala Arg Ala Glu Val Ser Gln Phe Ala Ala Cys Asn Leu Ala Gln 
1               5                   10                  15      


Ile Pro Pro His Ala Val Met Val Arg Pro Asp Thr Asn Ile Phe Thr 
            20                  25                  30          


Val Tyr Gly Leu Leu Asp Lys Ala Gln Asp Leu Phe Gly Asp Asp His 
        35                  40                  45              


Asn Lys Asn Gly Phe Lys Met Phe Asp Ser Ser Asn Tyr His Gly Gln 
    50                  55                  60                  


Asp Leu Leu Phe Lys Asp Ala Thr Val Arg Ala Val Pro Val Gly Glu 
65                  70                  75                  80  


Lys Thr Thr Tyr Arg Gly Trp Leu Gly Leu Asp Tyr Val Ala Ala Leu 
                85                  90                  95      


Glu Gly Met Ser Ser Gln Gln Cys 
            100                 


<210>  29
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  29

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  30
<211>  450
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Modified Trastuzumab Sequence

<400>  30

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Trp Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Thr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  31
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  31

Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
1               5                   10                  15      


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
            20                  25                  30          


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
        35                  40                  45              


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
    50                  55                  60                  


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
65                  70                  75                  80  


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
                85                  90                  95      


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
            100                 105                 110         


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
        115                 120                 125             


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
    130                 135                 140                 


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
145                 150                 155                 160 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
                165                 170                 175     


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
            180                 185                 190         


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
        195                 200                 205             


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
    210                 215                 220                 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230                 235                 240 


<210>  32
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  32

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  33
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified Trastuzumab Sequence

<400>  33

Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
1               5                   10                  15      


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
            20                  25                  30          


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
        35                  40                  45              


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
    50                  55                  60                  


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
65                  70                  75                  80  


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
                85                  90                  95      


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
            100                 105                 110         


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
        115                 120                 125             


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
    130                 135                 140                 


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
145                 150                 155                 160 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
                165                 170                 175     


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Trp Pro Pro Val Leu Asp 
            180                 185                 190         


Ser Asp Gly Ser Phe Phe Leu Thr Ser Lys Leu Thr Val Asp Lys Ser 
        195                 200                 205             


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
    210                 215                 220                 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230                 235                 240 


<210>  34
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified Trastuzumab Sequence

<400>  34

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Trp Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Thr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  35
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified Trastuzumab Sequence

<400>  35

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Tyr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Ala Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  36
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  36

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  37
<211>  1142
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  p97-trastuzumab heavy chain fusion protein

<400>  37

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys Gly Met Glu Val Arg Trp Cys Ala Thr Ser Asp Pro Glu Gln 
    450                 455                 460                 


His Lys Cys Gly Asn Met Ser Glu Ala Phe Arg Glu Ala Gly Ile Gln 
465                 470                 475                 480 


Pro Ser Leu Leu Cys Val Arg Gly Thr Ser Ala Asp His Cys Val Gln 
                485                 490                 495     


Leu Ile Ala Ala Gln Glu Ala Asp Ala Ile Thr Leu Asp Gly Gly Ala 
            500                 505                 510         


Ile Tyr Glu Ala Gly Lys Glu His Gly Leu Lys Pro Val Val Gly Glu 
        515                 520                 525             


Val Tyr Asp Gln Glu Val Gly Thr Ser Tyr Tyr Ala Val Ala Val Val 
    530                 535                 540                 


Arg Arg Ser Ser His Val Thr Ile Asp Thr Leu Lys Gly Val Lys Ser 
545                 550                 555                 560 


Cys His Thr Gly Ile Asn Arg Thr Val Gly Trp Asn Val Pro Val Gly 
                565                 570                 575     


Tyr Leu Val Glu Ser Gly Arg Leu Ser Val Met Gly Cys Asp Val Leu 
            580                 585                 590         


Lys Ala Val Ser Asp Tyr Phe Gly Gly Ser Cys Val Pro Gly Ala Gly 
        595                 600                 605             


Glu Thr Ser Tyr Ser Glu Ser Leu Cys Arg Leu Cys Arg Gly Asp Ser 
    610                 615                 620                 


Ser Gly Glu Gly Val Cys Asp Lys Ser Pro Leu Glu Arg Tyr Tyr Asp 
625                 630                 635                 640 


Tyr Ser Gly Ala Phe Arg Cys Leu Ala Glu Gly Ala Gly Asp Val Ala 
                645                 650                 655     


Phe Val Lys His Ser Thr Val Leu Glu Asn Thr Asp Gly Lys Thr Leu 
            660                 665                 670         


Pro Ser Trp Gly Gln Ala Leu Leu Ser Gln Asp Phe Glu Leu Leu Cys 
        675                 680                 685             


Arg Asp Gly Ser Arg Ala Asp Val Thr Glu Trp Arg Gln Cys His Leu 
    690                 695                 700                 


Ala Arg Val Pro Ala His Ala Val Val Val Arg Ala Asp Thr Asp Gly 
705                 710                 715                 720 


Gly Leu Ile Phe Arg Leu Leu Asn Glu Gly Gln Arg Leu Phe Ser His 
                725                 730                 735     


Glu Gly Ser Ser Phe Gln Met Phe Ser Ser Glu Ala Tyr Gly Gln Lys 
            740                 745                 750         


Asp Leu Leu Phe Lys Asp Ser Thr Ser Glu Leu Val Pro Ile Ala Thr 
        755                 760                 765             


Gln Thr Tyr Glu Ala Trp Leu Gly His Glu Tyr Leu His Ala Met Lys 
    770                 775                 780                 


Gly Leu Leu Cys Asp Pro Asn Arg Leu Pro Pro Tyr Leu Arg Trp Cys 
785                 790                 795                 800 


Val Leu Ser Thr Pro Glu Ile Gln Lys Cys Gly Asp Met Ala Val Ala 
                805                 810                 815     


Phe Arg Arg Gln Arg Leu Lys Pro Glu Ile Gln Cys Val Ser Ala Lys 
            820                 825                 830         


Ser Pro Gln His Cys Met Glu Arg Ile Gln Ala Glu Gln Val Asp Ala 
        835                 840                 845             


Val Thr Leu Ser Gly Glu Asp Ile Tyr Thr Ala Gly Lys Thr Tyr Gly 
    850                 855                 860                 


Leu Val Pro Ala Ala Gly Glu His Tyr Ala Pro Glu Asp Ser Ser Asn 
865                 870                 875                 880 


Ser Tyr Tyr Val Val Ala Val Val Arg Arg Asp Ser Ser His Ala Phe 
                885                 890                 895     


Thr Leu Asp Glu Leu Arg Gly Lys Arg Ser Cys His Ala Gly Phe Gly 
            900                 905                 910         


Ser Pro Ala Gly Trp Asp Val Pro Val Gly Ala Leu Ile Gln Arg Gly 
        915                 920                 925             


Phe Ile Arg Pro Lys Asp Cys Asp Val Leu Thr Ala Val Ser Glu Phe 
    930                 935                 940                 


Phe Asn Ala Ser Cys Val Pro Val Asn Asn Pro Lys Asn Tyr Pro Ser 
945                 950                 955                 960 


Ser Leu Cys Ala Leu Cys Val Gly Asp Glu Gln Gly Arg Asn Lys Cys 
                965                 970                 975     


Val Gly Asn Ser Gln Glu Arg Tyr Tyr Gly Tyr Arg Gly Ala Phe Arg 
            980                 985                 990         


Cys Leu Val Glu Asn Ala Gly Asp  Val Ala Phe Val Arg  His Thr Thr 
        995                 1000                 1005             


Val Phe  Asp Asn Thr Asn Gly  His Asn Ser Glu Pro  Trp Ala Ala 
    1010                 1015                 1020             


Glu Leu  Arg Ser Glu Asp Tyr  Glu Leu Leu Cys Pro  Asn Gly Ala 
    1025                 1030                 1035             


Arg Ala  Glu Val Ser Gln Phe  Ala Ala Cys Asn Leu  Ala Gln Ile 
    1040                 1045                 1050             


Pro Pro  His Ala Val Met Val  Arg Pro Asp Thr Asn  Ile Phe Thr 
    1055                 1060                 1065             


Val Tyr  Gly Leu Leu Asp Lys  Ala Gln Asp Leu Phe  Gly Asp Asp 
    1070                 1075                 1080             


His Asn  Lys Asn Gly Phe Lys  Met Phe Asp Ser Ser  Asn Tyr His 
    1085                 1090                 1095             


Gly Gln  Asp Leu Leu Phe Lys  Asp Ala Thr Val Arg  Ala Val Pro 
    1100                 1105                 1110             


Val Gly  Glu Lys Thr Thr Tyr  Arg Gly Trp Leu Gly  Leu Asp Tyr 
    1115                 1120                 1125             


Val Ala  Ala Leu Glu Gly Met  Ser Ser Gln Gln Cys  Ser Gly 
    1130                 1135                 1140         


<210>  38
<211>  1157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  p97-trastuzumab heavy chain fusion protein

<400>  38

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    450                 455                 460                 


Ser Gly Met Glu Val Arg Trp Cys Ala Thr Ser Asp Pro Glu Gln His 
465                 470                 475                 480 


Lys Cys Gly Asn Met Ser Glu Ala Phe Arg Glu Ala Gly Ile Gln Pro 
                485                 490                 495     


Ser Leu Leu Cys Val Arg Gly Thr Ser Ala Asp His Cys Val Gln Leu 
            500                 505                 510         


Ile Ala Ala Gln Glu Ala Asp Ala Ile Thr Leu Asp Gly Gly Ala Ile 
        515                 520                 525             


Tyr Glu Ala Gly Lys Glu His Gly Leu Lys Pro Val Val Gly Glu Val 
    530                 535                 540                 


Tyr Asp Gln Glu Val Gly Thr Ser Tyr Tyr Ala Val Ala Val Val Arg 
545                 550                 555                 560 


Arg Ser Ser His Val Thr Ile Asp Thr Leu Lys Gly Val Lys Ser Cys 
                565                 570                 575     


His Thr Gly Ile Asn Arg Thr Val Gly Trp Asn Val Pro Val Gly Tyr 
            580                 585                 590         


Leu Val Glu Ser Gly Arg Leu Ser Val Met Gly Cys Asp Val Leu Lys 
        595                 600                 605             


Ala Val Ser Asp Tyr Phe Gly Gly Ser Cys Val Pro Gly Ala Gly Glu 
    610                 615                 620                 


Thr Ser Tyr Ser Glu Ser Leu Cys Arg Leu Cys Arg Gly Asp Ser Ser 
625                 630                 635                 640 


Gly Glu Gly Val Cys Asp Lys Ser Pro Leu Glu Arg Tyr Tyr Asp Tyr 
                645                 650                 655     


Ser Gly Ala Phe Arg Cys Leu Ala Glu Gly Ala Gly Asp Val Ala Phe 
            660                 665                 670         


Val Lys His Ser Thr Val Leu Glu Asn Thr Asp Gly Lys Thr Leu Pro 
        675                 680                 685             


Ser Trp Gly Gln Ala Leu Leu Ser Gln Asp Phe Glu Leu Leu Cys Arg 
    690                 695                 700                 


Asp Gly Ser Arg Ala Asp Val Thr Glu Trp Arg Gln Cys His Leu Ala 
705                 710                 715                 720 


Arg Val Pro Ala His Ala Val Val Val Arg Ala Asp Thr Asp Gly Gly 
                725                 730                 735     


Leu Ile Phe Arg Leu Leu Asn Glu Gly Gln Arg Leu Phe Ser His Glu 
            740                 745                 750         


Gly Ser Ser Phe Gln Met Phe Ser Ser Glu Ala Tyr Gly Gln Lys Asp 
        755                 760                 765             


Leu Leu Phe Lys Asp Ser Thr Ser Glu Leu Val Pro Ile Ala Thr Gln 
    770                 775                 780                 


Thr Tyr Glu Ala Trp Leu Gly His Glu Tyr Leu His Ala Met Lys Gly 
785                 790                 795                 800 


Leu Leu Cys Asp Pro Asn Arg Leu Pro Pro Tyr Leu Arg Trp Cys Val 
                805                 810                 815     


Leu Ser Thr Pro Glu Ile Gln Lys Cys Gly Asp Met Ala Val Ala Phe 
            820                 825                 830         


Arg Arg Gln Arg Leu Lys Pro Glu Ile Gln Cys Val Ser Ala Lys Ser 
        835                 840                 845             


Pro Gln His Cys Met Glu Arg Ile Gln Ala Glu Gln Val Asp Ala Val 
    850                 855                 860                 


Thr Leu Ser Gly Glu Asp Ile Tyr Thr Ala Gly Lys Thr Tyr Gly Leu 
865                 870                 875                 880 


Val Pro Ala Ala Gly Glu His Tyr Ala Pro Glu Asp Ser Ser Asn Ser 
                885                 890                 895     


Tyr Tyr Val Val Ala Val Val Arg Arg Asp Ser Ser His Ala Phe Thr 
            900                 905                 910         


Leu Asp Glu Leu Arg Gly Lys Arg Ser Cys His Ala Gly Phe Gly Ser 
        915                 920                 925             


Pro Ala Gly Trp Asp Val Pro Val Gly Ala Leu Ile Gln Arg Gly Phe 
    930                 935                 940                 


Ile Arg Pro Lys Asp Cys Asp Val Leu Thr Ala Val Ser Glu Phe Phe 
945                 950                 955                 960 


Asn Ala Ser Cys Val Pro Val Asn Asn Pro Lys Asn Tyr Pro Ser Ser 
                965                 970                 975     


Leu Cys Ala Leu Cys Val Gly Asp Glu Gln Gly Arg Asn Lys Cys Val 
            980                 985                 990         


Gly Asn Ser Gln Glu Arg Tyr Tyr  Gly Tyr Arg Gly Ala  Phe Arg Cys 
        995                 1000                 1005             


Leu Val  Glu Asn Ala Gly Asp  Val Ala Phe Val Arg  His Thr Thr 
    1010                 1015                 1020             


Val Phe  Asp Asn Thr Asn Gly  His Asn Ser Glu Pro  Trp Ala Ala 
    1025                 1030                 1035             


Glu Leu  Arg Ser Glu Asp Tyr  Glu Leu Leu Cys Pro  Asn Gly Ala 
    1040                 1045                 1050             


Arg Ala  Glu Val Ser Gln Phe  Ala Ala Cys Asn Leu  Ala Gln Ile 
    1055                 1060                 1065             


Pro Pro  His Ala Val Met Val  Arg Pro Asp Thr Asn  Ile Phe Thr 
    1070                 1075                 1080             


Val Tyr  Gly Leu Leu Asp Lys  Ala Gln Asp Leu Phe  Gly Asp Asp 
    1085                 1090                 1095             


His Asn  Lys Asn Gly Phe Lys  Met Phe Asp Ser Ser  Asn Tyr His 
    1100                 1105                 1110             


Gly Gln  Asp Leu Leu Phe Lys  Asp Ala Thr Val Arg  Ala Val Pro 
    1115                 1120                 1125             


Val Gly  Glu Lys Thr Thr Tyr  Arg Gly Trp Leu Gly  Leu Asp Tyr 
    1130                 1135                 1140             


Val Ala  Ala Leu Glu Gly Met  Ser Ser Gln Gln Cys  Ser Gly 
    1145                 1150                 1155         


<210>  39
<211>  931
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  p97-trastuzumab heavy chain fusion protein

<400>  39

Gly Met Glu Val Arg Trp Cys Ala Thr Ser Asp Pro Glu Gln His Lys 
1               5                   10                  15      


Cys Gly Asn Met Ser Glu Ala Phe Arg Glu Ala Gly Ile Gln Pro Ser 
            20                  25                  30          


Leu Leu Cys Val Arg Gly Thr Ser Ala Asp His Cys Val Gln Leu Ile 
        35                  40                  45              


Ala Ala Gln Glu Ala Asp Ala Ile Thr Leu Asp Gly Gly Ala Ile Tyr 
    50                  55                  60                  


Glu Ala Gly Lys Glu His Gly Leu Lys Pro Val Val Gly Glu Val Tyr 
65                  70                  75                  80  


Asp Gln Glu Val Gly Thr Ser Tyr Tyr Ala Val Ala Val Val Arg Arg 
                85                  90                  95      


Ser Ser His Val Thr Ile Asp Thr Leu Lys Gly Val Lys Ser Cys His 
            100                 105                 110         


Thr Gly Ile Asn Arg Thr Val Gly Trp Asn Val Pro Val Gly Tyr Leu 
        115                 120                 125             


Val Glu Ser Gly Arg Leu Ser Val Met Gly Cys Asp Val Leu Lys Ala 
    130                 135                 140                 


Val Ser Asp Tyr Phe Gly Gly Ser Cys Val Pro Gly Ala Gly Glu Thr 
145                 150                 155                 160 


Ser Tyr Ser Glu Ser Leu Cys Arg Leu Cys Arg Gly Asp Ser Ser Gly 
                165                 170                 175     


Glu Gly Val Cys Asp Lys Ser Pro Leu Glu Arg Tyr Tyr Asp Tyr Ser 
            180                 185                 190         


Gly Ala Phe Arg Cys Leu Ala Glu Gly Ala Gly Asp Val Ala Phe Val 
        195                 200                 205             


Lys His Ser Thr Val Leu Glu Asn Thr Asp Gly Lys Thr Leu Pro Ser 
    210                 215                 220                 


Trp Gly Gln Ala Leu Leu Ser Gln Asp Phe Glu Leu Leu Cys Arg Asp 
225                 230                 235                 240 


Gly Ser Arg Ala Asp Val Thr Glu Trp Arg Gln Cys His Leu Ala Arg 
                245                 250                 255     


Val Pro Ala His Ala Val Val Val Arg Ala Asp Thr Asp Gly Gly Leu 
            260                 265                 270         


Ile Phe Arg Leu Leu Asn Glu Gly Gln Arg Leu Phe Ser His Glu Gly 
        275                 280                 285             


Ser Ser Phe Gln Met Phe Ser Ser Glu Ala Tyr Gly Gln Lys Asp Leu 
    290                 295                 300                 


Leu Phe Lys Asp Ser Thr Ser Glu Leu Val Pro Ile Ala Thr Gln Thr 
305                 310                 315                 320 


Tyr Glu Ala Trp Leu Gly His Glu Tyr Leu His Ala Met Lys Gly Leu 
                325                 330                 335     


Leu Cys Asp Pro Asn Arg Leu Pro Pro Tyr Leu Arg Trp Cys Val Leu 
            340                 345                 350         


Ser Thr Pro Glu Ile Gln Lys Cys Gly Asp Met Ala Val Ala Phe Arg 
        355                 360                 365             


Arg Gln Arg Leu Lys Pro Glu Ile Gln Cys Val Ser Ala Lys Ser Pro 
    370                 375                 380                 


Gln His Cys Met Glu Arg Ile Gln Ala Glu Gln Val Asp Ala Val Thr 
385                 390                 395                 400 


Leu Ser Gly Glu Asp Ile Tyr Thr Ala Gly Lys Thr Tyr Gly Leu Val 
                405                 410                 415     


Pro Ala Ala Gly Glu His Tyr Ala Pro Glu Asp Ser Ser Asn Ser Tyr 
            420                 425                 430         


Tyr Val Val Ala Val Val Arg Arg Asp Ser Ser His Ala Phe Thr Leu 
        435                 440                 445             


Asp Glu Leu Arg Gly Lys Arg Ser Cys His Ala Gly Phe Gly Ser Pro 
    450                 455                 460                 


Ala Gly Trp Asp Val Pro Val Gly Ala Leu Ile Gln Arg Gly Phe Ile 
465                 470                 475                 480 


Arg Pro Lys Asp Cys Asp Val Leu Thr Ala Val Ser Glu Phe Phe Asn 
                485                 490                 495     


Ala Ser Cys Val Pro Val Asn Asn Pro Lys Asn Tyr Pro Ser Ser Leu 
            500                 505                 510         


Cys Ala Leu Cys Val Gly Asp Glu Gln Gly Arg Asn Lys Cys Val Gly 
        515                 520                 525             


Asn Ser Gln Glu Arg Tyr Tyr Gly Tyr Arg Gly Ala Phe Arg Cys Leu 
    530                 535                 540                 


Val Glu Asn Ala Gly Asp Val Ala Phe Val Arg His Thr Thr Val Phe 
545                 550                 555                 560 


Asp Asn Thr Asn Gly His Asn Ser Glu Pro Trp Ala Ala Glu Leu Arg 
                565                 570                 575     


Ser Glu Asp Tyr Glu Leu Leu Cys Pro Asn Gly Ala Arg Ala Glu Val 
            580                 585                 590         


Ser Gln Phe Ala Ala Cys Asn Leu Ala Gln Ile Pro Pro His Ala Val 
        595                 600                 605             


Met Val Arg Pro Asp Thr Asn Ile Phe Thr Val Tyr Gly Leu Leu Asp 
    610                 615                 620                 


Lys Ala Gln Asp Leu Phe Gly Asp Asp His Asn Lys Asn Gly Phe Lys 
625                 630                 635                 640 


Met Phe Asp Ser Ser Asn Tyr His Gly Gln Asp Leu Leu Phe Lys Asp 
                645                 650                 655     


Ala Thr Val Arg Ala Val Pro Val Gly Glu Lys Thr Thr Tyr Arg Gly 
            660                 665                 670         


Trp Leu Gly Leu Asp Tyr Val Ala Ala Leu Glu Gly Met Ser Ser Gln 
        675                 680                 685             


Gln Cys Gly Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    690                 695                 700                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
705                 710                 715                 720 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                725                 730                 735     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            740                 745                 750         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        755                 760                 765             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    770                 775                 780                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
785                 790                 795                 800 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                805                 810                 815     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            820                 825                 830         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        835                 840                 845             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    850                 855                 860                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
865                 870                 875                 880 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                885                 890                 895     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            900                 905                 910         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        915                 920                 925             


Pro Gly Lys 
    930     


<210>  40
<211>  946
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  p97-trastuzumab heavy chain fusion protein

<400>  40

Gly Met Glu Val Arg Trp Cys Ala Thr Ser Asp Pro Glu Gln His Lys 
1               5                   10                  15      


Cys Gly Asn Met Ser Glu Ala Phe Arg Glu Ala Gly Ile Gln Pro Ser 
            20                  25                  30          


Leu Leu Cys Val Arg Gly Thr Ser Ala Asp His Cys Val Gln Leu Ile 
        35                  40                  45              


Ala Ala Gln Glu Ala Asp Ala Ile Thr Leu Asp Gly Gly Ala Ile Tyr 
    50                  55                  60                  


Glu Ala Gly Lys Glu His Gly Leu Lys Pro Val Val Gly Glu Val Tyr 
65                  70                  75                  80  


Asp Gln Glu Val Gly Thr Ser Tyr Tyr Ala Val Ala Val Val Arg Arg 
                85                  90                  95      


Ser Ser His Val Thr Ile Asp Thr Leu Lys Gly Val Lys Ser Cys His 
            100                 105                 110         


Thr Gly Ile Asn Arg Thr Val Gly Trp Asn Val Pro Val Gly Tyr Leu 
        115                 120                 125             


Val Glu Ser Gly Arg Leu Ser Val Met Gly Cys Asp Val Leu Lys Ala 
    130                 135                 140                 


Val Ser Asp Tyr Phe Gly Gly Ser Cys Val Pro Gly Ala Gly Glu Thr 
145                 150                 155                 160 


Ser Tyr Ser Glu Ser Leu Cys Arg Leu Cys Arg Gly Asp Ser Ser Gly 
                165                 170                 175     


Glu Gly Val Cys Asp Lys Ser Pro Leu Glu Arg Tyr Tyr Asp Tyr Ser 
            180                 185                 190         


Gly Ala Phe Arg Cys Leu Ala Glu Gly Ala Gly Asp Val Ala Phe Val 
        195                 200                 205             


Lys His Ser Thr Val Leu Glu Asn Thr Asp Gly Lys Thr Leu Pro Ser 
    210                 215                 220                 


Trp Gly Gln Ala Leu Leu Ser Gln Asp Phe Glu Leu Leu Cys Arg Asp 
225                 230                 235                 240 


Gly Ser Arg Ala Asp Val Thr Glu Trp Arg Gln Cys His Leu Ala Arg 
                245                 250                 255     


Val Pro Ala His Ala Val Val Val Arg Ala Asp Thr Asp Gly Gly Leu 
            260                 265                 270         


Ile Phe Arg Leu Leu Asn Glu Gly Gln Arg Leu Phe Ser His Glu Gly 
        275                 280                 285             


Ser Ser Phe Gln Met Phe Ser Ser Glu Ala Tyr Gly Gln Lys Asp Leu 
    290                 295                 300                 


Leu Phe Lys Asp Ser Thr Ser Glu Leu Val Pro Ile Ala Thr Gln Thr 
305                 310                 315                 320 


Tyr Glu Ala Trp Leu Gly His Glu Tyr Leu His Ala Met Lys Gly Leu 
                325                 330                 335     


Leu Cys Asp Pro Asn Arg Leu Pro Pro Tyr Leu Arg Trp Cys Val Leu 
            340                 345                 350         


Ser Thr Pro Glu Ile Gln Lys Cys Gly Asp Met Ala Val Ala Phe Arg 
        355                 360                 365             


Arg Gln Arg Leu Lys Pro Glu Ile Gln Cys Val Ser Ala Lys Ser Pro 
    370                 375                 380                 


Gln His Cys Met Glu Arg Ile Gln Ala Glu Gln Val Asp Ala Val Thr 
385                 390                 395                 400 


Leu Ser Gly Glu Asp Ile Tyr Thr Ala Gly Lys Thr Tyr Gly Leu Val 
                405                 410                 415     


Pro Ala Ala Gly Glu His Tyr Ala Pro Glu Asp Ser Ser Asn Ser Tyr 
            420                 425                 430         


Tyr Val Val Ala Val Val Arg Arg Asp Ser Ser His Ala Phe Thr Leu 
        435                 440                 445             


Asp Glu Leu Arg Gly Lys Arg Ser Cys His Ala Gly Phe Gly Ser Pro 
    450                 455                 460                 


Ala Gly Trp Asp Val Pro Val Gly Ala Leu Ile Gln Arg Gly Phe Ile 
465                 470                 475                 480 


Arg Pro Lys Asp Cys Asp Val Leu Thr Ala Val Ser Glu Phe Phe Asn 
                485                 490                 495     


Ala Ser Cys Val Pro Val Asn Asn Pro Lys Asn Tyr Pro Ser Ser Leu 
            500                 505                 510         


Cys Ala Leu Cys Val Gly Asp Glu Gln Gly Arg Asn Lys Cys Val Gly 
        515                 520                 525             


Asn Ser Gln Glu Arg Tyr Tyr Gly Tyr Arg Gly Ala Phe Arg Cys Leu 
    530                 535                 540                 


Val Glu Asn Ala Gly Asp Val Ala Phe Val Arg His Thr Thr Val Phe 
545                 550                 555                 560 


Asp Asn Thr Asn Gly His Asn Ser Glu Pro Trp Ala Ala Glu Leu Arg 
                565                 570                 575     


Ser Glu Asp Tyr Glu Leu Leu Cys Pro Asn Gly Ala Arg Ala Glu Val 
            580                 585                 590         


Ser Gln Phe Ala Ala Cys Asn Leu Ala Gln Ile Pro Pro His Ala Val 
        595                 600                 605             


Met Val Arg Pro Asp Thr Asn Ile Phe Thr Val Tyr Gly Leu Leu Asp 
    610                 615                 620                 


Lys Ala Gln Asp Leu Phe Gly Asp Asp His Asn Lys Asn Gly Phe Lys 
625                 630                 635                 640 


Met Phe Asp Ser Ser Asn Tyr His Gly Gln Asp Leu Leu Phe Lys Asp 
                645                 650                 655     


Ala Thr Val Arg Ala Val Pro Val Gly Glu Lys Thr Thr Tyr Arg Gly 
            660                 665                 670         


Trp Leu Gly Leu Asp Tyr Val Ala Ala Leu Glu Gly Met Ser Ser Gln 
        675                 680                 685             


Gln Cys Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    690                 695                 700                 


Gly Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
705                 710                 715                 720 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
                725                 730                 735     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            740                 745                 750         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        755                 760                 765             


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    770                 775                 780                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
785                 790                 795                 800 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                805                 810                 815     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
            820                 825                 830         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        835                 840                 845             


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
    850                 855                 860                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
865                 870                 875                 880 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                885                 890                 895     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            900                 905                 910         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        915                 920                 925             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    930                 935                 940                 


Gly Lys 
945     


<210>  41
<211>  918
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  p97-trastuzumab heavy chain fusion protein

<400>  41

Gly Met Glu Val Arg Trp Cys Ala Thr Ser Asp Pro Glu Gln His Lys 
1               5                   10                  15      


Cys Gly Asn Met Ser Glu Ala Phe Arg Glu Ala Gly Ile Gln Pro Ser 
            20                  25                  30          


Leu Leu Cys Val Arg Gly Thr Ser Ala Asp His Cys Val Gln Leu Ile 
        35                  40                  45              


Ala Ala Gln Glu Ala Asp Ala Ile Thr Leu Asp Gly Gly Ala Ile Tyr 
    50                  55                  60                  


Glu Ala Gly Lys Glu His Gly Leu Lys Pro Val Val Gly Glu Val Tyr 
65                  70                  75                  80  


Asp Gln Glu Val Gly Thr Ser Tyr Tyr Ala Val Ala Val Val Arg Arg 
                85                  90                  95      


Ser Ser His Val Thr Ile Asp Thr Leu Lys Gly Val Lys Ser Cys His 
            100                 105                 110         


Thr Gly Ile Asn Arg Thr Val Gly Trp Asn Val Pro Val Gly Tyr Leu 
        115                 120                 125             


Val Glu Ser Gly Arg Leu Ser Val Met Gly Cys Asp Val Leu Lys Ala 
    130                 135                 140                 


Val Ser Asp Tyr Phe Gly Gly Ser Cys Val Pro Gly Ala Gly Glu Thr 
145                 150                 155                 160 


Ser Tyr Ser Glu Ser Leu Cys Arg Leu Cys Arg Gly Asp Ser Ser Gly 
                165                 170                 175     


Glu Gly Val Cys Asp Lys Ser Pro Leu Glu Arg Tyr Tyr Asp Tyr Ser 
            180                 185                 190         


Gly Ala Phe Arg Cys Leu Ala Glu Gly Ala Gly Asp Val Ala Phe Val 
        195                 200                 205             


Lys His Ser Thr Val Leu Glu Asn Thr Asp Gly Lys Thr Leu Pro Ser 
    210                 215                 220                 


Trp Gly Gln Ala Leu Leu Ser Gln Asp Phe Glu Leu Leu Cys Arg Asp 
225                 230                 235                 240 


Gly Ser Arg Ala Asp Val Thr Glu Trp Arg Gln Cys His Leu Ala Arg 
                245                 250                 255     


Val Pro Ala His Ala Val Val Val Arg Ala Asp Thr Asp Gly Gly Leu 
            260                 265                 270         


Ile Phe Arg Leu Leu Asn Glu Gly Gln Arg Leu Phe Ser His Glu Gly 
        275                 280                 285             


Ser Ser Phe Gln Met Phe Ser Ser Glu Ala Tyr Gly Gln Lys Asp Leu 
    290                 295                 300                 


Leu Phe Lys Asp Ser Thr Ser Glu Leu Val Pro Ile Ala Thr Gln Thr 
305                 310                 315                 320 


Tyr Glu Ala Trp Leu Gly His Glu Tyr Leu His Ala Met Lys Gly Leu 
                325                 330                 335     


Leu Cys Asp Pro Asn Arg Leu Pro Pro Tyr Leu Arg Trp Cys Val Leu 
            340                 345                 350         


Ser Thr Pro Glu Ile Gln Lys Cys Gly Asp Met Ala Val Ala Phe Arg 
        355                 360                 365             


Arg Gln Arg Leu Lys Pro Glu Ile Gln Cys Val Ser Ala Lys Ser Pro 
    370                 375                 380                 


Gln His Cys Met Glu Arg Ile Gln Ala Glu Gln Val Asp Ala Val Thr 
385                 390                 395                 400 


Leu Ser Gly Glu Asp Ile Tyr Thr Ala Gly Lys Thr Tyr Gly Leu Val 
                405                 410                 415     


Pro Ala Ala Gly Glu His Tyr Ala Pro Glu Asp Ser Ser Asn Ser Tyr 
            420                 425                 430         


Tyr Val Val Ala Val Val Arg Arg Asp Ser Ser His Ala Phe Thr Leu 
        435                 440                 445             


Asp Glu Leu Arg Gly Lys Arg Ser Cys His Ala Gly Phe Gly Ser Pro 
    450                 455                 460                 


Ala Gly Trp Asp Val Pro Val Gly Ala Leu Ile Gln Arg Gly Phe Ile 
465                 470                 475                 480 


Arg Pro Lys Asp Cys Asp Val Leu Thr Ala Val Ser Glu Phe Phe Asn 
                485                 490                 495     


Ala Ser Cys Val Pro Val Asn Asn Pro Lys Asn Tyr Pro Ser Ser Leu 
            500                 505                 510         


Cys Ala Leu Cys Val Gly Asp Glu Gln Gly Arg Asn Lys Cys Val Gly 
        515                 520                 525             


Asn Ser Gln Glu Arg Tyr Tyr Gly Tyr Arg Gly Ala Phe Arg Cys Leu 
    530                 535                 540                 


Val Glu Asn Ala Gly Asp Val Ala Phe Val Arg His Thr Thr Val Phe 
545                 550                 555                 560 


Asp Asn Thr Asn Gly His Asn Ser Glu Pro Trp Ala Ala Glu Leu Arg 
                565                 570                 575     


Ser Glu Asp Tyr Glu Leu Leu Cys Pro Asn Gly Ala Arg Ala Glu Val 
            580                 585                 590         


Ser Gln Phe Ala Ala Cys Asn Leu Ala Gln Ile Pro Pro His Ala Val 
        595                 600                 605             


Met Val Arg Pro Asp Thr Asn Ile Phe Thr Val Tyr Gly Leu Leu Asp 
    610                 615                 620                 


Lys Ala Gln Asp Leu Phe Gly Asp Asp His Asn Lys Asn Gly Phe Lys 
625                 630                 635                 640 


Met Phe Asp Ser Ser Asn Tyr His Gly Gln Asp Leu Leu Phe Lys Asp 
                645                 650                 655     


Ala Thr Val Arg Ala Val Pro Val Gly Glu Lys Thr Thr Tyr Arg Gly 
            660                 665                 670         


Trp Leu Gly Leu Asp Tyr Val Ala Ala Leu Glu Gly Met Ser Ser Gln 
        675                 680                 685             


Gln Cys Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
    690                 695                 700                 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
705                 710                 715                 720 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                725                 730                 735     


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
            740                 745                 750         


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
        755                 760                 765             


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
    770                 775                 780                 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
785                 790                 795                 800 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
                805                 810                 815     


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
            820                 825                 830         


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
        835                 840                 845             


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
    850                 855                 860                 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
865                 870                 875                 880 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
                885                 890                 895     


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
            900                 905                 910         


Ser Leu Ser Pro Gly Lys 
        915             


<210>  42
<211>  933
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  p97-trastuzumab heavy chain fusion protein

<400>  42

Gly Met Glu Val Arg Trp Cys Ala Thr Ser Asp Pro Glu Gln His Lys 
1               5                   10                  15      


Cys Gly Asn Met Ser Glu Ala Phe Arg Glu Ala Gly Ile Gln Pro Ser 
            20                  25                  30          


Leu Leu Cys Val Arg Gly Thr Ser Ala Asp His Cys Val Gln Leu Ile 
        35                  40                  45              


Ala Ala Gln Glu Ala Asp Ala Ile Thr Leu Asp Gly Gly Ala Ile Tyr 
    50                  55                  60                  


Glu Ala Gly Lys Glu His Gly Leu Lys Pro Val Val Gly Glu Val Tyr 
65                  70                  75                  80  


Asp Gln Glu Val Gly Thr Ser Tyr Tyr Ala Val Ala Val Val Arg Arg 
                85                  90                  95      


Ser Ser His Val Thr Ile Asp Thr Leu Lys Gly Val Lys Ser Cys His 
            100                 105                 110         


Thr Gly Ile Asn Arg Thr Val Gly Trp Asn Val Pro Val Gly Tyr Leu 
        115                 120                 125             


Val Glu Ser Gly Arg Leu Ser Val Met Gly Cys Asp Val Leu Lys Ala 
    130                 135                 140                 


Val Ser Asp Tyr Phe Gly Gly Ser Cys Val Pro Gly Ala Gly Glu Thr 
145                 150                 155                 160 


Ser Tyr Ser Glu Ser Leu Cys Arg Leu Cys Arg Gly Asp Ser Ser Gly 
                165                 170                 175     


Glu Gly Val Cys Asp Lys Ser Pro Leu Glu Arg Tyr Tyr Asp Tyr Ser 
            180                 185                 190         


Gly Ala Phe Arg Cys Leu Ala Glu Gly Ala Gly Asp Val Ala Phe Val 
        195                 200                 205             


Lys His Ser Thr Val Leu Glu Asn Thr Asp Gly Lys Thr Leu Pro Ser 
    210                 215                 220                 


Trp Gly Gln Ala Leu Leu Ser Gln Asp Phe Glu Leu Leu Cys Arg Asp 
225                 230                 235                 240 


Gly Ser Arg Ala Asp Val Thr Glu Trp Arg Gln Cys His Leu Ala Arg 
                245                 250                 255     


Val Pro Ala His Ala Val Val Val Arg Ala Asp Thr Asp Gly Gly Leu 
            260                 265                 270         


Ile Phe Arg Leu Leu Asn Glu Gly Gln Arg Leu Phe Ser His Glu Gly 
        275                 280                 285             


Ser Ser Phe Gln Met Phe Ser Ser Glu Ala Tyr Gly Gln Lys Asp Leu 
    290                 295                 300                 


Leu Phe Lys Asp Ser Thr Ser Glu Leu Val Pro Ile Ala Thr Gln Thr 
305                 310                 315                 320 


Tyr Glu Ala Trp Leu Gly His Glu Tyr Leu His Ala Met Lys Gly Leu 
                325                 330                 335     


Leu Cys Asp Pro Asn Arg Leu Pro Pro Tyr Leu Arg Trp Cys Val Leu 
            340                 345                 350         


Ser Thr Pro Glu Ile Gln Lys Cys Gly Asp Met Ala Val Ala Phe Arg 
        355                 360                 365             


Arg Gln Arg Leu Lys Pro Glu Ile Gln Cys Val Ser Ala Lys Ser Pro 
    370                 375                 380                 


Gln His Cys Met Glu Arg Ile Gln Ala Glu Gln Val Asp Ala Val Thr 
385                 390                 395                 400 


Leu Ser Gly Glu Asp Ile Tyr Thr Ala Gly Lys Thr Tyr Gly Leu Val 
                405                 410                 415     


Pro Ala Ala Gly Glu His Tyr Ala Pro Glu Asp Ser Ser Asn Ser Tyr 
            420                 425                 430         


Tyr Val Val Ala Val Val Arg Arg Asp Ser Ser His Ala Phe Thr Leu 
        435                 440                 445             


Asp Glu Leu Arg Gly Lys Arg Ser Cys His Ala Gly Phe Gly Ser Pro 
    450                 455                 460                 


Ala Gly Trp Asp Val Pro Val Gly Ala Leu Ile Gln Arg Gly Phe Ile 
465                 470                 475                 480 


Arg Pro Lys Asp Cys Asp Val Leu Thr Ala Val Ser Glu Phe Phe Asn 
                485                 490                 495     


Ala Ser Cys Val Pro Val Asn Asn Pro Lys Asn Tyr Pro Ser Ser Leu 
            500                 505                 510         


Cys Ala Leu Cys Val Gly Asp Glu Gln Gly Arg Asn Lys Cys Val Gly 
        515                 520                 525             


Asn Ser Gln Glu Arg Tyr Tyr Gly Tyr Arg Gly Ala Phe Arg Cys Leu 
    530                 535                 540                 


Val Glu Asn Ala Gly Asp Val Ala Phe Val Arg His Thr Thr Val Phe 
545                 550                 555                 560 


Asp Asn Thr Asn Gly His Asn Ser Glu Pro Trp Ala Ala Glu Leu Arg 
                565                 570                 575     


Ser Glu Asp Tyr Glu Leu Leu Cys Pro Asn Gly Ala Arg Ala Glu Val 
            580                 585                 590         


Ser Gln Phe Ala Ala Cys Asn Leu Ala Gln Ile Pro Pro His Ala Val 
        595                 600                 605             


Met Val Arg Pro Asp Thr Asn Ile Phe Thr Val Tyr Gly Leu Leu Asp 
    610                 615                 620                 


Lys Ala Gln Asp Leu Phe Gly Asp Asp His Asn Lys Asn Gly Phe Lys 
625                 630                 635                 640 


Met Phe Asp Ser Ser Asn Tyr His Gly Gln Asp Leu Leu Phe Lys Asp 
                645                 650                 655     


Ala Thr Val Arg Ala Val Pro Val Gly Glu Lys Thr Thr Tyr Arg Gly 
            660                 665                 670         


Trp Leu Gly Leu Asp Tyr Val Ala Ala Leu Glu Gly Met Ser Ser Gln 
        675                 680                 685             


Gln Cys Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    690                 695                 700                 


Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
705                 710                 715                 720 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                725                 730                 735     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            740                 745                 750         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        755                 760                 765             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    770                 775                 780                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
785                 790                 795                 800 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                805                 810                 815     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            820                 825                 830         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        835                 840                 845             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    850                 855                 860                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
865                 870                 875                 880 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                885                 890                 895     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            900                 905                 910         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        915                 920                 925             


Leu Ser Pro Gly Lys 
    930             


<210>  43
<211>  932
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  p97-trastuzumab heavy chain fusion protein

<400>  43

Gly Met Glu Val Arg Trp Cys Ala Thr Ser Asp Pro Glu Gln His Lys 
1               5                   10                  15      


Cys Gly Asn Met Ser Glu Ala Phe Arg Glu Ala Gly Ile Gln Pro Ser 
            20                  25                  30          


Leu Leu Cys Val Arg Gly Thr Ser Ala Asp His Cys Val Gln Leu Ile 
        35                  40                  45              


Ala Ala Gln Glu Ala Asp Ala Ile Thr Leu Asp Gly Gly Ala Ile Tyr 
    50                  55                  60                  


Glu Ala Gly Lys Glu His Gly Leu Lys Pro Val Val Gly Glu Val Tyr 
65                  70                  75                  80  


Asp Gln Glu Val Gly Thr Ser Tyr Tyr Ala Val Ala Val Val Arg Arg 
                85                  90                  95      


Ser Ser His Val Thr Ile Asp Thr Leu Lys Gly Val Lys Ser Cys His 
            100                 105                 110         


Thr Gly Ile Asn Arg Thr Val Gly Trp Asn Val Pro Val Gly Tyr Leu 
        115                 120                 125             


Val Glu Ser Gly Arg Leu Ser Val Met Gly Cys Asp Val Leu Lys Ala 
    130                 135                 140                 


Val Ser Asp Tyr Phe Gly Gly Ser Cys Val Pro Gly Ala Gly Glu Thr 
145                 150                 155                 160 


Ser Tyr Ser Glu Ser Leu Cys Arg Leu Cys Arg Gly Asp Ser Ser Gly 
                165                 170                 175     


Glu Gly Val Cys Asp Lys Ser Pro Leu Glu Arg Tyr Tyr Asp Tyr Ser 
            180                 185                 190         


Gly Ala Phe Arg Cys Leu Ala Glu Gly Ala Gly Asp Val Ala Phe Val 
        195                 200                 205             


Lys His Ser Thr Val Leu Glu Asn Thr Asp Gly Lys Thr Leu Pro Ser 
    210                 215                 220                 


Trp Gly Gln Ala Leu Leu Ser Gln Asp Phe Glu Leu Leu Cys Arg Asp 
225                 230                 235                 240 


Gly Ser Arg Ala Asp Val Thr Glu Trp Arg Gln Cys His Leu Ala Arg 
                245                 250                 255     


Val Pro Ala His Ala Val Val Val Arg Ala Asp Thr Asp Gly Gly Leu 
            260                 265                 270         


Ile Phe Arg Leu Leu Asn Glu Gly Gln Arg Leu Phe Ser His Glu Gly 
        275                 280                 285             


Ser Ser Phe Gln Met Phe Ser Ser Glu Ala Tyr Gly Gln Lys Asp Leu 
    290                 295                 300                 


Leu Phe Lys Asp Ser Thr Ser Glu Leu Val Pro Ile Ala Thr Gln Thr 
305                 310                 315                 320 


Tyr Glu Ala Trp Leu Gly His Glu Tyr Leu His Ala Met Lys Gly Leu 
                325                 330                 335     


Leu Cys Asp Pro Asn Arg Leu Pro Pro Tyr Leu Arg Trp Cys Val Leu 
            340                 345                 350         


Ser Thr Pro Glu Ile Gln Lys Cys Gly Asp Met Ala Val Ala Phe Arg 
        355                 360                 365             


Arg Gln Arg Leu Lys Pro Glu Ile Gln Cys Val Ser Ala Lys Ser Pro 
    370                 375                 380                 


Gln His Cys Met Glu Arg Ile Gln Ala Glu Gln Val Asp Ala Val Thr 
385                 390                 395                 400 


Leu Ser Gly Glu Asp Ile Tyr Thr Ala Gly Lys Thr Tyr Gly Leu Val 
                405                 410                 415     


Pro Ala Ala Gly Glu His Tyr Ala Pro Glu Asp Ser Ser Asn Ser Tyr 
            420                 425                 430         


Tyr Val Val Ala Val Val Arg Arg Asp Ser Ser His Ala Phe Thr Leu 
        435                 440                 445             


Asp Glu Leu Arg Gly Lys Arg Ser Cys His Ala Gly Phe Gly Ser Pro 
    450                 455                 460                 


Ala Gly Trp Asp Val Pro Val Gly Ala Leu Ile Gln Arg Gly Phe Ile 
465                 470                 475                 480 


Arg Pro Lys Asp Cys Asp Val Leu Thr Ala Val Ser Glu Phe Phe Asn 
                485                 490                 495     


Ala Ser Cys Val Pro Val Asn Asn Pro Lys Asn Tyr Pro Ser Ser Leu 
            500                 505                 510         


Cys Ala Leu Cys Val Gly Asp Glu Gln Gly Arg Asn Lys Cys Val Gly 
        515                 520                 525             


Asn Ser Gln Glu Arg Tyr Tyr Gly Tyr Arg Gly Ala Phe Arg Cys Leu 
    530                 535                 540                 


Val Glu Asn Ala Gly Asp Val Ala Phe Val Arg His Thr Thr Val Phe 
545                 550                 555                 560 


Asp Asn Thr Asn Gly His Asn Ser Glu Pro Trp Ala Ala Glu Leu Arg 
                565                 570                 575     


Ser Glu Asp Tyr Glu Leu Leu Cys Pro Asn Gly Ala Arg Ala Glu Val 
            580                 585                 590         


Ser Gln Phe Ala Ala Cys Asn Leu Ala Gln Ile Pro Pro His Ala Val 
        595                 600                 605             


Met Val Arg Pro Asp Thr Asn Ile Phe Thr Val Tyr Gly Leu Leu Asp 
    610                 615                 620                 


Lys Ala Gln Asp Leu Phe Gly Asp Asp His Asn Lys Asn Gly Phe Lys 
625                 630                 635                 640 


Met Phe Asp Ser Ser Asn Tyr His Gly Gln Asp Leu Leu Phe Lys Asp 
                645                 650                 655     


Ala Thr Val Arg Ala Val Pro Val Gly Glu Lys Thr Thr Tyr Arg Gly 
            660                 665                 670         


Trp Leu Gly Leu Asp Tyr Val Ala Ala Leu Glu Gly Met Ser Ser Gln 
        675                 680                 685             


Gln Cys Ser Gly Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    690                 695                 700                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
705                 710                 715                 720 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                725                 730                 735     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            740                 745                 750         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        755                 760                 765             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    770                 775                 780                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
785                 790                 795                 800 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                805                 810                 815     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            820                 825                 830         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        835                 840                 845             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    850                 855                 860                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Trp Pro 
865                 870                 875                 880 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Thr Ser Lys Leu Thr 
                885                 890                 895     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            900                 905                 910         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        915                 920                 925             


Ser Pro Gly Lys 
    930         


<210>  44
<211>  947
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  p97-trastuzumab heavy chain fusion protein

<400>  44

Gly Met Glu Val Arg Trp Cys Ala Thr Ser Asp Pro Glu Gln His Lys 
1               5                   10                  15      


Cys Gly Asn Met Ser Glu Ala Phe Arg Glu Ala Gly Ile Gln Pro Ser 
            20                  25                  30          


Leu Leu Cys Val Arg Gly Thr Ser Ala Asp His Cys Val Gln Leu Ile 
        35                  40                  45              


Ala Ala Gln Glu Ala Asp Ala Ile Thr Leu Asp Gly Gly Ala Ile Tyr 
    50                  55                  60                  


Glu Ala Gly Lys Glu His Gly Leu Lys Pro Val Val Gly Glu Val Tyr 
65                  70                  75                  80  


Asp Gln Glu Val Gly Thr Ser Tyr Tyr Ala Val Ala Val Val Arg Arg 
                85                  90                  95      


Ser Ser His Val Thr Ile Asp Thr Leu Lys Gly Val Lys Ser Cys His 
            100                 105                 110         


Thr Gly Ile Asn Arg Thr Val Gly Trp Asn Val Pro Val Gly Tyr Leu 
        115                 120                 125             


Val Glu Ser Gly Arg Leu Ser Val Met Gly Cys Asp Val Leu Lys Ala 
    130                 135                 140                 


Val Ser Asp Tyr Phe Gly Gly Ser Cys Val Pro Gly Ala Gly Glu Thr 
145                 150                 155                 160 


Ser Tyr Ser Glu Ser Leu Cys Arg Leu Cys Arg Gly Asp Ser Ser Gly 
                165                 170                 175     


Glu Gly Val Cys Asp Lys Ser Pro Leu Glu Arg Tyr Tyr Asp Tyr Ser 
            180                 185                 190         


Gly Ala Phe Arg Cys Leu Ala Glu Gly Ala Gly Asp Val Ala Phe Val 
        195                 200                 205             


Lys His Ser Thr Val Leu Glu Asn Thr Asp Gly Lys Thr Leu Pro Ser 
    210                 215                 220                 


Trp Gly Gln Ala Leu Leu Ser Gln Asp Phe Glu Leu Leu Cys Arg Asp 
225                 230                 235                 240 


Gly Ser Arg Ala Asp Val Thr Glu Trp Arg Gln Cys His Leu Ala Arg 
                245                 250                 255     


Val Pro Ala His Ala Val Val Val Arg Ala Asp Thr Asp Gly Gly Leu 
            260                 265                 270         


Ile Phe Arg Leu Leu Asn Glu Gly Gln Arg Leu Phe Ser His Glu Gly 
        275                 280                 285             


Ser Ser Phe Gln Met Phe Ser Ser Glu Ala Tyr Gly Gln Lys Asp Leu 
    290                 295                 300                 


Leu Phe Lys Asp Ser Thr Ser Glu Leu Val Pro Ile Ala Thr Gln Thr 
305                 310                 315                 320 


Tyr Glu Ala Trp Leu Gly His Glu Tyr Leu His Ala Met Lys Gly Leu 
                325                 330                 335     


Leu Cys Asp Pro Asn Arg Leu Pro Pro Tyr Leu Arg Trp Cys Val Leu 
            340                 345                 350         


Ser Thr Pro Glu Ile Gln Lys Cys Gly Asp Met Ala Val Ala Phe Arg 
        355                 360                 365             


Arg Gln Arg Leu Lys Pro Glu Ile Gln Cys Val Ser Ala Lys Ser Pro 
    370                 375                 380                 


Gln His Cys Met Glu Arg Ile Gln Ala Glu Gln Val Asp Ala Val Thr 
385                 390                 395                 400 


Leu Ser Gly Glu Asp Ile Tyr Thr Ala Gly Lys Thr Tyr Gly Leu Val 
                405                 410                 415     


Pro Ala Ala Gly Glu His Tyr Ala Pro Glu Asp Ser Ser Asn Ser Tyr 
            420                 425                 430         


Tyr Val Val Ala Val Val Arg Arg Asp Ser Ser His Ala Phe Thr Leu 
        435                 440                 445             


Asp Glu Leu Arg Gly Lys Arg Ser Cys His Ala Gly Phe Gly Ser Pro 
    450                 455                 460                 


Ala Gly Trp Asp Val Pro Val Gly Ala Leu Ile Gln Arg Gly Phe Ile 
465                 470                 475                 480 


Arg Pro Lys Asp Cys Asp Val Leu Thr Ala Val Ser Glu Phe Phe Asn 
                485                 490                 495     


Ala Ser Cys Val Pro Val Asn Asn Pro Lys Asn Tyr Pro Ser Ser Leu 
            500                 505                 510         


Cys Ala Leu Cys Val Gly Asp Glu Gln Gly Arg Asn Lys Cys Val Gly 
        515                 520                 525             


Asn Ser Gln Glu Arg Tyr Tyr Gly Tyr Arg Gly Ala Phe Arg Cys Leu 
    530                 535                 540                 


Val Glu Asn Ala Gly Asp Val Ala Phe Val Arg His Thr Thr Val Phe 
545                 550                 555                 560 


Asp Asn Thr Asn Gly His Asn Ser Glu Pro Trp Ala Ala Glu Leu Arg 
                565                 570                 575     


Ser Glu Asp Tyr Glu Leu Leu Cys Pro Asn Gly Ala Arg Ala Glu Val 
            580                 585                 590         


Ser Gln Phe Ala Ala Cys Asn Leu Ala Gln Ile Pro Pro His Ala Val 
        595                 600                 605             


Met Val Arg Pro Asp Thr Asn Ile Phe Thr Val Tyr Gly Leu Leu Asp 
    610                 615                 620                 


Lys Ala Gln Asp Leu Phe Gly Asp Asp His Asn Lys Asn Gly Phe Lys 
625                 630                 635                 640 


Met Phe Asp Ser Ser Asn Tyr His Gly Gln Asp Leu Leu Phe Lys Asp 
                645                 650                 655     


Ala Thr Val Arg Ala Val Pro Val Gly Glu Lys Thr Thr Tyr Arg Gly 
            660                 665                 670         


Trp Leu Gly Leu Asp Tyr Val Ala Ala Leu Glu Gly Met Ser Ser Gln 
        675                 680                 685             


Gln Cys Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    690                 695                 700                 


Gly Gly Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
705                 710                 715                 720 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
                725                 730                 735     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            740                 745                 750         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        755                 760                 765             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    770                 775                 780                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
785                 790                 795                 800 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                805                 810                 815     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            820                 825                 830         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        835                 840                 845             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    850                 855                 860                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
865                 870                 875                 880 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Trp Pro Pro 
                885                 890                 895     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Thr Ser Lys Leu Thr Val 
            900                 905                 910         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        915                 920                 925             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    930                 935                 940                 


Pro Gly Lys 
945         


<210>  45
<211>  919
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  p97-trastuzumab heavy chain fusion protein

<400>  45

Gly Met Glu Val Arg Trp Cys Ala Thr Ser Asp Pro Glu Gln His Lys 
1               5                   10                  15      


Cys Gly Asn Met Ser Glu Ala Phe Arg Glu Ala Gly Ile Gln Pro Ser 
            20                  25                  30          


Leu Leu Cys Val Arg Gly Thr Ser Ala Asp His Cys Val Gln Leu Ile 
        35                  40                  45              


Ala Ala Gln Glu Ala Asp Ala Ile Thr Leu Asp Gly Gly Ala Ile Tyr 
    50                  55                  60                  


Glu Ala Gly Lys Glu His Gly Leu Lys Pro Val Val Gly Glu Val Tyr 
65                  70                  75                  80  


Asp Gln Glu Val Gly Thr Ser Tyr Tyr Ala Val Ala Val Val Arg Arg 
                85                  90                  95      


Ser Ser His Val Thr Ile Asp Thr Leu Lys Gly Val Lys Ser Cys His 
            100                 105                 110         


Thr Gly Ile Asn Arg Thr Val Gly Trp Asn Val Pro Val Gly Tyr Leu 
        115                 120                 125             


Val Glu Ser Gly Arg Leu Ser Val Met Gly Cys Asp Val Leu Lys Ala 
    130                 135                 140                 


Val Ser Asp Tyr Phe Gly Gly Ser Cys Val Pro Gly Ala Gly Glu Thr 
145                 150                 155                 160 


Ser Tyr Ser Glu Ser Leu Cys Arg Leu Cys Arg Gly Asp Ser Ser Gly 
                165                 170                 175     


Glu Gly Val Cys Asp Lys Ser Pro Leu Glu Arg Tyr Tyr Asp Tyr Ser 
            180                 185                 190         


Gly Ala Phe Arg Cys Leu Ala Glu Gly Ala Gly Asp Val Ala Phe Val 
        195                 200                 205             


Lys His Ser Thr Val Leu Glu Asn Thr Asp Gly Lys Thr Leu Pro Ser 
    210                 215                 220                 


Trp Gly Gln Ala Leu Leu Ser Gln Asp Phe Glu Leu Leu Cys Arg Asp 
225                 230                 235                 240 


Gly Ser Arg Ala Asp Val Thr Glu Trp Arg Gln Cys His Leu Ala Arg 
                245                 250                 255     


Val Pro Ala His Ala Val Val Val Arg Ala Asp Thr Asp Gly Gly Leu 
            260                 265                 270         


Ile Phe Arg Leu Leu Asn Glu Gly Gln Arg Leu Phe Ser His Glu Gly 
        275                 280                 285             


Ser Ser Phe Gln Met Phe Ser Ser Glu Ala Tyr Gly Gln Lys Asp Leu 
    290                 295                 300                 


Leu Phe Lys Asp Ser Thr Ser Glu Leu Val Pro Ile Ala Thr Gln Thr 
305                 310                 315                 320 


Tyr Glu Ala Trp Leu Gly His Glu Tyr Leu His Ala Met Lys Gly Leu 
                325                 330                 335     


Leu Cys Asp Pro Asn Arg Leu Pro Pro Tyr Leu Arg Trp Cys Val Leu 
            340                 345                 350         


Ser Thr Pro Glu Ile Gln Lys Cys Gly Asp Met Ala Val Ala Phe Arg 
        355                 360                 365             


Arg Gln Arg Leu Lys Pro Glu Ile Gln Cys Val Ser Ala Lys Ser Pro 
    370                 375                 380                 


Gln His Cys Met Glu Arg Ile Gln Ala Glu Gln Val Asp Ala Val Thr 
385                 390                 395                 400 


Leu Ser Gly Glu Asp Ile Tyr Thr Ala Gly Lys Thr Tyr Gly Leu Val 
                405                 410                 415     


Pro Ala Ala Gly Glu His Tyr Ala Pro Glu Asp Ser Ser Asn Ser Tyr 
            420                 425                 430         


Tyr Val Val Ala Val Val Arg Arg Asp Ser Ser His Ala Phe Thr Leu 
        435                 440                 445             


Asp Glu Leu Arg Gly Lys Arg Ser Cys His Ala Gly Phe Gly Ser Pro 
    450                 455                 460                 


Ala Gly Trp Asp Val Pro Val Gly Ala Leu Ile Gln Arg Gly Phe Ile 
465                 470                 475                 480 


Arg Pro Lys Asp Cys Asp Val Leu Thr Ala Val Ser Glu Phe Phe Asn 
                485                 490                 495     


Ala Ser Cys Val Pro Val Asn Asn Pro Lys Asn Tyr Pro Ser Ser Leu 
            500                 505                 510         


Cys Ala Leu Cys Val Gly Asp Glu Gln Gly Arg Asn Lys Cys Val Gly 
        515                 520                 525             


Asn Ser Gln Glu Arg Tyr Tyr Gly Tyr Arg Gly Ala Phe Arg Cys Leu 
    530                 535                 540                 


Val Glu Asn Ala Gly Asp Val Ala Phe Val Arg His Thr Thr Val Phe 
545                 550                 555                 560 


Asp Asn Thr Asn Gly His Asn Ser Glu Pro Trp Ala Ala Glu Leu Arg 
                565                 570                 575     


Ser Glu Asp Tyr Glu Leu Leu Cys Pro Asn Gly Ala Arg Ala Glu Val 
            580                 585                 590         


Ser Gln Phe Ala Ala Cys Asn Leu Ala Gln Ile Pro Pro His Ala Val 
        595                 600                 605             


Met Val Arg Pro Asp Thr Asn Ile Phe Thr Val Tyr Gly Leu Leu Asp 
    610                 615                 620                 


Lys Ala Gln Asp Leu Phe Gly Asp Asp His Asn Lys Asn Gly Phe Lys 
625                 630                 635                 640 


Met Phe Asp Ser Ser Asn Tyr His Gly Gln Asp Leu Leu Phe Lys Asp 
                645                 650                 655     


Ala Thr Val Arg Ala Val Pro Val Gly Glu Lys Thr Thr Tyr Arg Gly 
            660                 665                 670         


Trp Leu Gly Leu Asp Tyr Val Ala Ala Leu Glu Gly Met Ser Ser Gln 
        675                 680                 685             


Gln Cys Ser Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
    690                 695                 700                 


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
705                 710                 715                 720 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                725                 730                 735     


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
            740                 745                 750         


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
        755                 760                 765             


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
    770                 775                 780                 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
785                 790                 795                 800 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
                805                 810                 815     


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
            820                 825                 830         


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        835                 840                 845             


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    850                 855                 860                 


Thr Trp Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Thr Ser 
865                 870                 875                 880 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
                885                 890                 895     


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            900                 905                 910         


Leu Ser Leu Ser Pro Gly Lys 
        915                 


<210>  46
<211>  934
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  p97-trastuzumab heavy chain fusion protein

<400>  46

Gly Met Glu Val Arg Trp Cys Ala Thr Ser Asp Pro Glu Gln His Lys 
1               5                   10                  15      


Cys Gly Asn Met Ser Glu Ala Phe Arg Glu Ala Gly Ile Gln Pro Ser 
            20                  25                  30          


Leu Leu Cys Val Arg Gly Thr Ser Ala Asp His Cys Val Gln Leu Ile 
        35                  40                  45              


Ala Ala Gln Glu Ala Asp Ala Ile Thr Leu Asp Gly Gly Ala Ile Tyr 
    50                  55                  60                  


Glu Ala Gly Lys Glu His Gly Leu Lys Pro Val Val Gly Glu Val Tyr 
65                  70                  75                  80  


Asp Gln Glu Val Gly Thr Ser Tyr Tyr Ala Val Ala Val Val Arg Arg 
                85                  90                  95      


Ser Ser His Val Thr Ile Asp Thr Leu Lys Gly Val Lys Ser Cys His 
            100                 105                 110         


Thr Gly Ile Asn Arg Thr Val Gly Trp Asn Val Pro Val Gly Tyr Leu 
        115                 120                 125             


Val Glu Ser Gly Arg Leu Ser Val Met Gly Cys Asp Val Leu Lys Ala 
    130                 135                 140                 


Val Ser Asp Tyr Phe Gly Gly Ser Cys Val Pro Gly Ala Gly Glu Thr 
145                 150                 155                 160 


Ser Tyr Ser Glu Ser Leu Cys Arg Leu Cys Arg Gly Asp Ser Ser Gly 
                165                 170                 175     


Glu Gly Val Cys Asp Lys Ser Pro Leu Glu Arg Tyr Tyr Asp Tyr Ser 
            180                 185                 190         


Gly Ala Phe Arg Cys Leu Ala Glu Gly Ala Gly Asp Val Ala Phe Val 
        195                 200                 205             


Lys His Ser Thr Val Leu Glu Asn Thr Asp Gly Lys Thr Leu Pro Ser 
    210                 215                 220                 


Trp Gly Gln Ala Leu Leu Ser Gln Asp Phe Glu Leu Leu Cys Arg Asp 
225                 230                 235                 240 


Gly Ser Arg Ala Asp Val Thr Glu Trp Arg Gln Cys His Leu Ala Arg 
                245                 250                 255     


Val Pro Ala His Ala Val Val Val Arg Ala Asp Thr Asp Gly Gly Leu 
            260                 265                 270         


Ile Phe Arg Leu Leu Asn Glu Gly Gln Arg Leu Phe Ser His Glu Gly 
        275                 280                 285             


Ser Ser Phe Gln Met Phe Ser Ser Glu Ala Tyr Gly Gln Lys Asp Leu 
    290                 295                 300                 


Leu Phe Lys Asp Ser Thr Ser Glu Leu Val Pro Ile Ala Thr Gln Thr 
305                 310                 315                 320 


Tyr Glu Ala Trp Leu Gly His Glu Tyr Leu His Ala Met Lys Gly Leu 
                325                 330                 335     


Leu Cys Asp Pro Asn Arg Leu Pro Pro Tyr Leu Arg Trp Cys Val Leu 
            340                 345                 350         


Ser Thr Pro Glu Ile Gln Lys Cys Gly Asp Met Ala Val Ala Phe Arg 
        355                 360                 365             


Arg Gln Arg Leu Lys Pro Glu Ile Gln Cys Val Ser Ala Lys Ser Pro 
    370                 375                 380                 


Gln His Cys Met Glu Arg Ile Gln Ala Glu Gln Val Asp Ala Val Thr 
385                 390                 395                 400 


Leu Ser Gly Glu Asp Ile Tyr Thr Ala Gly Lys Thr Tyr Gly Leu Val 
                405                 410                 415     


Pro Ala Ala Gly Glu His Tyr Ala Pro Glu Asp Ser Ser Asn Ser Tyr 
            420                 425                 430         


Tyr Val Val Ala Val Val Arg Arg Asp Ser Ser His Ala Phe Thr Leu 
        435                 440                 445             


Asp Glu Leu Arg Gly Lys Arg Ser Cys His Ala Gly Phe Gly Ser Pro 
    450                 455                 460                 


Ala Gly Trp Asp Val Pro Val Gly Ala Leu Ile Gln Arg Gly Phe Ile 
465                 470                 475                 480 


Arg Pro Lys Asp Cys Asp Val Leu Thr Ala Val Ser Glu Phe Phe Asn 
                485                 490                 495     


Ala Ser Cys Val Pro Val Asn Asn Pro Lys Asn Tyr Pro Ser Ser Leu 
            500                 505                 510         


Cys Ala Leu Cys Val Gly Asp Glu Gln Gly Arg Asn Lys Cys Val Gly 
        515                 520                 525             


Asn Ser Gln Glu Arg Tyr Tyr Gly Tyr Arg Gly Ala Phe Arg Cys Leu 
    530                 535                 540                 


Val Glu Asn Ala Gly Asp Val Ala Phe Val Arg His Thr Thr Val Phe 
545                 550                 555                 560 


Asp Asn Thr Asn Gly His Asn Ser Glu Pro Trp Ala Ala Glu Leu Arg 
                565                 570                 575     


Ser Glu Asp Tyr Glu Leu Leu Cys Pro Asn Gly Ala Arg Ala Glu Val 
            580                 585                 590         


Ser Gln Phe Ala Ala Cys Asn Leu Ala Gln Ile Pro Pro His Ala Val 
        595                 600                 605             


Met Val Arg Pro Asp Thr Asn Ile Phe Thr Val Tyr Gly Leu Leu Asp 
    610                 615                 620                 


Lys Ala Gln Asp Leu Phe Gly Asp Asp His Asn Lys Asn Gly Phe Lys 
625                 630                 635                 640 


Met Phe Asp Ser Ser Asn Tyr His Gly Gln Asp Leu Leu Phe Lys Asp 
                645                 650                 655     


Ala Thr Val Arg Ala Val Pro Val Gly Glu Lys Thr Thr Tyr Arg Gly 
            660                 665                 670         


Trp Leu Gly Leu Asp Tyr Val Ala Ala Leu Glu Gly Met Ser Ser Gln 
        675                 680                 685             


Gln Cys Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    690                 695                 700                 


Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
705                 710                 715                 720 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                725                 730                 735     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            740                 745                 750         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        755                 760                 765             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    770                 775                 780                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
785                 790                 795                 800 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                805                 810                 815     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            820                 825                 830         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        835                 840                 845             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    850                 855                 860                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
865                 870                 875                 880 


Trp Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Thr Ser Lys 
                885                 890                 895     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            900                 905                 910         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        915                 920                 925             


Ser Leu Ser Pro Gly Lys 
    930                 


<210>  47
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  47

Gly Ser Gly Ser 
1               


<210>  48
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  48

Gly Gly Ser Gly 
1               


<210>  49
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  49

Gly Gly Gly Ser 
1               


<210>  50
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Linker

<400>  50

Gly Gly Gly Gly Ser 
1               5   


<210>  51
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  51

Gly Asn Gly Asn 
1               


<210>  52
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  52

Gly Gly Asn Gly 
1               


<210>  53
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  53

Gly Gly Gly Asn 
1               


<210>  54
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  54

Gly Gly Gly Gly Asn 
1               5   


<210>  55
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  55

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  56
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin cleavable linker

<400>  56

Gly Arg Gly Asp 
1               


<210>  57
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin cleavable linker

<400>  57

Gly Arg Gly Asp Asn Pro 
1               5       


<210>  58
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin cleavable linker

<400>  58

Gly Arg Gly Asp Ser 
1               5   


<210>  59
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin cleavable linker

<400>  59

Gly Arg Gly Asp Ser Pro Lys 
1               5           


<210>  60
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Elastase cleavable linker

<400>  60

Ala Ala Pro Val 
1               


<210>  61
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Elastase cleavable linker

<400>  61

Ala Ala Pro Leu 
1               


<210>  62
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Elastase cleavable linker

<400>  62

Ala Ala Pro Phe 
1               


<210>  63
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Elastase cleavable linker

<400>  63

Ala Ala Pro Ala 
1               


<210>  64
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Elastase cleavable linker

<400>  64

Ala Tyr Leu Val 
1               


<210>  65
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Matrix metalloproteinase cleavable linker


<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa = Any amino acid

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Xaa = Any amino acid

<400>  65

Gly Pro Xaa Gly Pro Xaa 
1               5       


<210>  66
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Matrix metalloproteinase cleavable linker


<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Xaa = Any amino acid

<400>  66

Leu Gly Pro Xaa 
1               


<210>  67
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Matrix metalloproteinase cleavable linker


<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Xaa = Any amino acid

<400>  67

Gly Pro Ile Gly Pro Xaa 
1               5       


<210>  68
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Matrix metalloproteinase cleavable linker


<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Xaa = Any amino acid

<400>  68

Ala Pro Gly Leu Xaa 
1               5   


<210>  69
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Collagenase cleavable linker


<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa = Any amino acid

<400>  69

Pro Leu Gly Pro Asp Arg Xaa 
1               5           


<210>  70
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Collagenase cleavable linker


<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa = Any amino acid

<400>  70

Pro Leu Gly Leu Leu Gly Xaa 
1               5           


<210>  71
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Collagenase cleavable linker

<400>  71

Pro Gln Gly Ile Ala Gly Trp 
1               5           


<210>  72
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Collagenase cleavable linker

<400>  72

Pro Leu Gly Cys His 
1               5   


<210>  73
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Collagenase cleavable linker

<400>  73

Pro Leu Gly Leu Tyr Ala 
1               5       


<210>  74
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Collagenase cleavable linker

<400>  74

Pro Leu Ala Leu Trp Ala Arg 
1               5           


<210>  75
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Collagenase cleavable linker

<400>  75

Pro Leu Ala Tyr Trp Ala Arg 
1               5           


<210>  76
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Stromelysin cleavable linker

<400>  76

Pro Tyr Ala Tyr Tyr Met Arg 
1               5           


<210>  77
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Gelatinase cleavable linker

<400>  77

Pro Leu Gly Met Tyr Ser Arg 
1               5           


<210>  78
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Angiotensin converting enzyme cleavable linker

<400>  78

Gly Asp Lys Pro 
1               


<210>  79
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Angiotensin converting enzyme cleavable linker

<400>  79

Gly Ser Asp Lys Pro 
1               5   


<210>  80
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cathepsin B cleavable linker

<400>  80

Ala Leu Ala Leu 
1               


<210>  81
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cathepsin B cleavable linker

<400>  81

Gly Phe Leu Gly 
1               


<210>  82
<211>  1171
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TZM heavy chain - linker - p97 fusion protein

<400>  82

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn 
        35                  40                  45              


Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys 
                85                  90                  95      


Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
465                 470                 475                 480 


Gly Met Glu Val Arg Trp Cys Ala Thr Ser Asp Pro Glu Gln His Lys 
                485                 490                 495     


Cys Gly Asn Met Ser Glu Ala Phe Arg Glu Ala Gly Ile Gln Pro Ser 
            500                 505                 510         


Leu Leu Cys Val Arg Gly Thr Ser Ala Asp His Cys Val Gln Leu Ile 
        515                 520                 525             


Ala Ala Gln Glu Ala Asp Ala Ile Thr Leu Asp Gly Gly Ala Ile Tyr 
    530                 535                 540                 


Glu Ala Gly Lys Glu His Gly Leu Lys Pro Val Val Gly Glu Val Tyr 
545                 550                 555                 560 


Asp Gln Glu Val Gly Thr Ser Tyr Tyr Ala Val Ala Val Val Arg Arg 
                565                 570                 575     


Ser Ser His Val Thr Ile Asp Thr Leu Lys Gly Val Lys Ser Cys His 
            580                 585                 590         


Thr Gly Ile Asn Arg Thr Val Gly Trp Asn Val Pro Val Gly Tyr Leu 
        595                 600                 605             


Val Glu Ser Gly Arg Leu Ser Val Met Gly Cys Asp Val Leu Lys Ala 
    610                 615                 620                 


Val Ser Asp Tyr Phe Gly Gly Ser Cys Val Pro Gly Ala Gly Glu Thr 
625                 630                 635                 640 


Ser Tyr Ser Glu Ser Leu Cys Arg Leu Cys Arg Gly Asp Ser Ser Gly 
                645                 650                 655     


Glu Gly Val Cys Asp Lys Ser Pro Leu Glu Arg Tyr Tyr Asp Tyr Ser 
            660                 665                 670         


Gly Ala Phe Arg Cys Leu Ala Glu Gly Ala Gly Asp Val Ala Phe Val 
        675                 680                 685             


Lys His Ser Thr Val Leu Glu Asn Thr Asp Gly Lys Thr Leu Pro Ser 
    690                 695                 700                 


Trp Gly Gln Ala Leu Leu Ser Gln Asp Phe Glu Leu Leu Cys Arg Asp 
705                 710                 715                 720 


Gly Ser Arg Ala Asp Val Thr Glu Trp Arg Gln Cys His Leu Ala Arg 
                725                 730                 735     


Val Pro Ala His Ala Val Val Val Arg Ala Asp Thr Asp Gly Gly Leu 
            740                 745                 750         


Ile Phe Arg Leu Leu Asn Glu Gly Gln Arg Leu Phe Ser His Glu Gly 
        755                 760                 765             


Ser Ser Phe Gln Met Phe Ser Ser Glu Ala Tyr Gly Gln Lys Asp Leu 
    770                 775                 780                 


Leu Phe Lys Asp Ser Thr Ser Glu Leu Val Pro Ile Ala Thr Gln Thr 
785                 790                 795                 800 


Tyr Glu Ala Trp Leu Gly His Glu Tyr Leu His Ala Met Lys Gly Leu 
                805                 810                 815     


Leu Cys Asp Pro Asn Arg Leu Pro Pro Tyr Leu Arg Trp Cys Val Leu 
            820                 825                 830         


Ser Thr Pro Glu Ile Gln Lys Cys Gly Asp Met Ala Val Ala Phe Arg 
        835                 840                 845             


Arg Gln Arg Leu Lys Pro Glu Ile Gln Cys Val Ser Ala Lys Ser Pro 
    850                 855                 860                 


Gln His Cys Met Glu Arg Ile Gln Ala Glu Gln Val Asp Ala Val Thr 
865                 870                 875                 880 


Leu Ser Gly Glu Asp Ile Tyr Thr Ala Gly Lys Thr Tyr Gly Leu Val 
                885                 890                 895     


Pro Ala Ala Gly Glu His Tyr Ala Pro Glu Asp Ser Ser Asn Ser Tyr 
            900                 905                 910         


Tyr Val Val Ala Val Val Arg Arg Asp Ser Ser His Ala Phe Thr Leu 
        915                 920                 925             


Asp Glu Leu Arg Gly Lys Arg Ser Cys His Ala Gly Phe Gly Ser Pro 
    930                 935                 940                 


Ala Gly Trp Asp Val Pro Val Gly Ala Leu Ile Gln Arg Gly Phe Ile 
945                 950                 955                 960 


Arg Pro Lys Asp Cys Asp Val Leu Thr Ala Val Ser Glu Phe Phe Asn 
                965                 970                 975     


Ala Ser Cys Val Pro Val Asn Asn Pro Lys Asn Tyr Pro Ser Ser Leu 
            980                 985                 990         


Cys Ala Leu Cys Val Gly Asp Glu  Gln Gly Arg Asn Lys  Cys Val Gly 
        995                 1000                 1005             


Asn Ser  Gln Glu Arg Tyr Tyr  Gly Tyr Arg Gly Ala  Phe Arg Cys 
    1010                 1015                 1020             


Leu Val  Glu Asn Ala Gly Asp  Val Ala Phe Val Arg  His Thr Thr 
    1025                 1030                 1035             


Val Phe  Asp Asn Thr Asn Gly  His Asn Ser Glu Pro  Trp Ala Ala 
    1040                 1045                 1050             


Glu Leu  Arg Ser Glu Asp Tyr  Glu Leu Leu Cys Pro  Asn Gly Ala 
    1055                 1060                 1065             


Arg Ala  Glu Val Ser Gln Phe  Ala Ala Cys Asn Leu  Ala Gln Ile 
    1070                 1075                 1080             


Pro Pro  His Ala Val Met Val  Arg Pro Asp Thr Asn  Ile Phe Thr 
    1085                 1090                 1095             


Val Tyr  Gly Leu Leu Asp Lys  Ala Gln Asp Leu Phe  Gly Asp Asp 
    1100                 1105                 1110             


His Asn  Lys Asn Gly Phe Lys  Met Phe Asp Ser Ser  Asn Tyr His 
    1115                 1120                 1125             


Gly Gln  Asp Leu Leu Phe Lys  Asp Ala Thr Val Arg  Ala Val Pro 
    1130                 1135                 1140             


Val Gly  Glu Lys Thr Thr Tyr  Arg Gly Trp Leu Gly  Leu Asp Tyr 
    1145                 1150                 1155             


Val Ala  Ala Leu Glu Gly Met  Ser Ser Gln Gln Cys  Ser 
    1160                 1165                 1170     


<210>  83
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  83

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr 
            100                 105                 110         


Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  84
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  p97 fragment - linker - TZM heavy chain fusion protein

<400>  84

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ser Ser His Ala Phe Thr Leu Asp Glu Leu Arg 
            20                  25                  30          


Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
        35                  40                  45              


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    50                  55                  60                  


Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val 
65                  70                  75                  80  


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro 
                85                  90                  95      


Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
            100                 105                 110         


Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser 
        115                 120                 125             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly 
    130                 135                 140                 


Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
145                 150                 155                 160 


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
                165                 170                 175     


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
            180                 185                 190         


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
        195                 200                 205             


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
    210                 215                 220                 


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
225                 230                 235                 240 


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
                245                 250                 255     


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
            260                 265                 270         


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
        275                 280                 285             


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
    290                 295                 300                 


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
305                 310                 315                 320 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
                325                 330                 335     


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
            340                 345                 350         


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
        355                 360                 365             


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
    370                 375                 380                 


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
385                 390                 395                 400 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
                405                 410                 415     


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
            420                 425                 430         


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
        435                 440                 445             


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
    450                 455                 460                 


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
465                 470                 475                 480 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                485                 490             


<210>  85
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  85

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr 
            100                 105                 110         


Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  86
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TZM heavy chain - llinker - p97 fragment fusion protein

<400>  86

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn 
        35                  40                  45              


Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys 
                85                  90                  95      


Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
465                 470                 475                 480 


Asp Ser Ser His Ala Phe Thr Leu Asp Glu Leu Arg 
                485                 490         


<210>  87
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  87

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr 
            100                 105                 110         


Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  88
<211>  1177
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TZM heavy chain - linker - p97 fusion protein

<400>  88

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn 
        35                  40                  45              


Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys 
                85                  90                  95      


Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
465                 470                 475                 480 


Gly Gly Gly Gly Ser Gly Met Glu Val Arg Trp Cys Ala Thr Ser Asp 
                485                 490                 495     


Pro Glu Gln His Lys Cys Gly Asn Met Ser Glu Ala Phe Arg Glu Ala 
            500                 505                 510         


Gly Ile Gln Pro Ser Leu Leu Cys Val Arg Gly Thr Ser Ala Asp His 
        515                 520                 525             


Cys Val Gln Leu Ile Ala Ala Gln Glu Ala Asp Ala Ile Thr Leu Asp 
    530                 535                 540                 


Gly Gly Ala Ile Tyr Glu Ala Gly Lys Glu His Gly Leu Lys Pro Val 
545                 550                 555                 560 


Val Gly Glu Val Tyr Asp Gln Glu Val Gly Thr Ser Tyr Tyr Ala Val 
                565                 570                 575     


Ala Val Val Arg Arg Ser Ser His Val Thr Ile Asp Thr Leu Lys Gly 
            580                 585                 590         


Val Lys Ser Cys His Thr Gly Ile Asn Arg Thr Val Gly Trp Asn Val 
        595                 600                 605             


Pro Val Gly Tyr Leu Val Glu Ser Gly Arg Leu Ser Val Met Gly Cys 
    610                 615                 620                 


Asp Val Leu Lys Ala Val Ser Asp Tyr Phe Gly Gly Ser Cys Val Pro 
625                 630                 635                 640 


Gly Ala Gly Glu Thr Ser Tyr Ser Glu Ser Leu Cys Arg Leu Cys Arg 
                645                 650                 655     


Gly Asp Ser Ser Gly Glu Gly Val Cys Asp Lys Ser Pro Leu Glu Arg 
            660                 665                 670         


Tyr Tyr Asp Tyr Ser Gly Ala Phe Arg Cys Leu Ala Glu Gly Ala Gly 
        675                 680                 685             


Asp Val Ala Phe Val Lys His Ser Thr Val Leu Glu Asn Thr Asp Gly 
    690                 695                 700                 


Lys Thr Leu Pro Ser Trp Gly Gln Ala Leu Leu Ser Gln Asp Phe Glu 
705                 710                 715                 720 


Leu Leu Cys Arg Asp Gly Ser Arg Ala Asp Val Thr Glu Trp Arg Gln 
                725                 730                 735     


Cys His Leu Ala Arg Val Pro Ala His Ala Val Val Val Arg Ala Asp 
            740                 745                 750         


Thr Asp Gly Gly Leu Ile Phe Arg Leu Leu Asn Glu Gly Gln Arg Leu 
        755                 760                 765             


Phe Ser His Glu Gly Ser Ser Phe Gln Met Phe Ser Ser Glu Ala Tyr 
    770                 775                 780                 


Gly Gln Lys Asp Leu Leu Phe Lys Asp Ser Thr Ser Glu Leu Val Pro 
785                 790                 795                 800 


Ile Ala Thr Gln Thr Tyr Glu Ala Trp Leu Gly His Glu Tyr Leu His 
                805                 810                 815     


Ala Met Lys Gly Leu Leu Cys Asp Pro Asn Arg Leu Pro Pro Tyr Leu 
            820                 825                 830         


Arg Trp Cys Val Leu Ser Thr Pro Glu Ile Gln Lys Cys Gly Asp Met 
        835                 840                 845             


Ala Val Ala Phe Arg Arg Gln Arg Leu Lys Pro Glu Ile Gln Cys Val 
    850                 855                 860                 


Ser Ala Lys Ser Pro Gln His Cys Met Glu Arg Ile Gln Ala Glu Gln 
865                 870                 875                 880 


Val Asp Ala Val Thr Leu Ser Gly Glu Asp Ile Tyr Thr Ala Gly Lys 
                885                 890                 895     


Thr Tyr Gly Leu Val Pro Ala Ala Gly Glu His Tyr Ala Pro Glu Asp 
            900                 905                 910         


Ser Ser Asn Ser Tyr Tyr Val Val Ala Val Val Arg Arg Asp Ser Ser 
        915                 920                 925             


His Ala Phe Thr Leu Asp Glu Leu Arg Gly Lys Arg Ser Cys His Ala 
    930                 935                 940                 


Gly Phe Gly Ser Pro Ala Gly Trp Asp Val Pro Val Gly Ala Leu Ile 
945                 950                 955                 960 


Gln Arg Gly Phe Ile Arg Pro Lys Asp Cys Asp Val Leu Thr Ala Val 
                965                 970                 975     


Ser Glu Phe Phe Asn Ala Ser Cys Val Pro Val Asn Asn Pro Lys Asn 
            980                 985                 990         


Tyr Pro Ser Ser Leu Cys Ala Leu  Cys Val Gly Asp Glu  Gln Gly Arg 
        995                 1000                 1005             


Asn Lys  Cys Val Gly Asn Ser  Gln Glu Arg Tyr Tyr  Gly Tyr Arg 
    1010                 1015                 1020             


Gly Ala  Phe Arg Cys Leu Val  Glu Asn Ala Gly Asp  Val Ala Phe 
    1025                 1030                 1035             


Val Arg  His Thr Thr Val Phe  Asp Asn Thr Asn Gly  His Asn Ser 
    1040                 1045                 1050             


Glu Pro  Trp Ala Ala Glu Leu  Arg Ser Glu Asp Tyr  Glu Leu Leu 
    1055                 1060                 1065             


Cys Pro  Asn Gly Ala Arg Ala  Glu Val Ser Gln Phe  Ala Ala Cys 
    1070                 1075                 1080             


Asn Leu  Ala Gln Ile Pro Pro  His Ala Val Met Val  Arg Pro Asp 
    1085                 1090                 1095             


Thr Asn  Ile Phe Thr Val Tyr  Gly Leu Leu Asp Lys  Ala Gln Asp 
    1100                 1105                 1110             


Leu Phe  Gly Asp Asp His Asn  Lys Asn Gly Phe Lys  Met Phe Asp 
    1115                 1120                 1125             


Ser Ser  Asn Tyr His Gly Gln  Asp Leu Leu Phe Lys  Asp Ala Thr 
    1130                 1135                 1140             


Val Arg  Ala Val Pro Val Gly  Glu Lys Thr Thr Tyr  Arg Gly Trp 
    1145                 1150                 1155             


Leu Gly  Leu Asp Tyr Val Ala  Ala Leu Glu Gly Met  Ser Ser Gln 
    1160                 1165                 1170             


Gln Cys  Ser Gly 
    1175         


<210>  89
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  89

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr 
            100                 105                 110         


Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  90
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TZM heavy chain - linker - p97 fragment fusion protein

<400>  90

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn 
        35                  40                  45              


Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys 
                85                  90                  95      


Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala 
465                 470                 475                 480 


Lys Glu Ala Ala Ala Lys Asp Ser Ser His Ala Phe Thr Leu Asp Glu 
                485                 490                 495     


Leu Arg Tyr 
            


<210>  91
<211>  262
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TZM light chain - linker - p97 fragment fusion protein

<400>  91

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr 
            100                 105                 110         


Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Glu Ala Ala Ala Lys Glu 
225                 230                 235                 240 


Ala Ala Ala Lys Glu Ala Ala Ala Lys Asp Ser Ser His Ala Phe Thr 
                245                 250                 255     


Leu Asp Glu Leu Arg Tyr 
            260         


<210>  92
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TZM heavy chain - linker - p97 fragment

<400>  92

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn 
        35                  40                  45              


Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys 
                85                  90                  95      


Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala 
465                 470                 475                 480 


Lys Glu Ala Ala Ala Lys Asp Ser Ser His Ala Phe Thr Leu Asp Glu 
                485                 490                 495     


Leu Arg Tyr 
            


<210>  93
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  93

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr 
            100                 105                 110         


Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  94
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TZM heavy chain - linker - p97 fragment fusion protein

<400>  94

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn 
        35                  40                  45              


Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys 
                85                  90                  95      


Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys 
465                 470     


<210>  95
<211>  262
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TZM light chain - linker - p97 fragment fusion protein

<400>  95

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr 
            100                 105                 110         


Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Glu Ala Ala Ala Lys Glu 
225                 230                 235                 240 


Ala Ala Ala Lys Glu Ala Ala Ala Lys Asp Ser Ser His Ala Phe Thr 
                245                 250                 255     


Leu Asp Glu Leu Arg Tyr 
            260         


<210>  96
<211>  1151
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TZM heavy chain - linker - p97 fusion protein

<400>  96

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Met Glu Val 
    450                 455                 460                 


Arg Trp Cys Ala Thr Ser Asp Pro Glu Gln His Lys Cys Gly Asn Met 
465                 470                 475                 480 


Ser Glu Ala Phe Arg Glu Ala Gly Ile Gln Pro Ser Leu Leu Cys Val 
                485                 490                 495     


Arg Gly Thr Ser Ala Asp His Cys Val Gln Leu Ile Ala Ala Gln Glu 
            500                 505                 510         


Ala Asp Ala Ile Thr Leu Asp Gly Gly Ala Ile Tyr Glu Ala Gly Lys 
        515                 520                 525             


Glu His Gly Leu Lys Pro Val Val Gly Glu Val Tyr Asp Gln Glu Val 
    530                 535                 540                 


Gly Thr Ser Tyr Tyr Ala Val Ala Val Val Arg Arg Ser Ser His Val 
545                 550                 555                 560 


Thr Ile Asp Thr Leu Lys Gly Val Lys Ser Cys His Thr Gly Ile Asn 
                565                 570                 575     


Arg Thr Val Gly Trp Asn Val Pro Val Gly Tyr Leu Val Glu Ser Gly 
            580                 585                 590         


Arg Leu Ser Val Met Gly Cys Asp Val Leu Lys Ala Val Ser Asp Tyr 
        595                 600                 605             


Phe Gly Gly Ser Cys Val Pro Gly Ala Gly Glu Thr Ser Tyr Ser Glu 
    610                 615                 620                 


Ser Leu Cys Arg Leu Cys Arg Gly Asp Ser Ser Gly Glu Gly Val Cys 
625                 630                 635                 640 


Asp Lys Ser Pro Leu Glu Arg Tyr Tyr Asp Tyr Ser Gly Ala Phe Arg 
                645                 650                 655     


Cys Leu Ala Glu Gly Ala Gly Asp Val Ala Phe Val Lys His Ser Thr 
            660                 665                 670         


Val Leu Glu Asn Thr Asp Gly Lys Thr Leu Pro Ser Trp Gly Gln Ala 
        675                 680                 685             


Leu Leu Ser Gln Asp Phe Glu Leu Leu Cys Arg Asp Gly Ser Arg Ala 
    690                 695                 700                 


Asp Val Thr Glu Trp Arg Gln Cys His Leu Ala Arg Val Pro Ala His 
705                 710                 715                 720 


Ala Val Val Val Arg Ala Asp Thr Asp Gly Gly Leu Ile Phe Arg Leu 
                725                 730                 735     


Leu Asn Glu Gly Gln Arg Leu Phe Ser His Glu Gly Ser Ser Phe Gln 
            740                 745                 750         


Met Phe Ser Ser Glu Ala Tyr Gly Gln Lys Asp Leu Leu Phe Lys Asp 
        755                 760                 765             


Ser Thr Ser Glu Leu Val Pro Ile Ala Thr Gln Thr Tyr Glu Ala Trp 
    770                 775                 780                 


Leu Gly His Glu Tyr Leu His Ala Met Lys Gly Leu Leu Cys Asp Pro 
785                 790                 795                 800 


Asn Arg Leu Pro Pro Tyr Leu Arg Trp Cys Val Leu Ser Thr Pro Glu 
                805                 810                 815     


Ile Gln Lys Cys Gly Asp Met Ala Val Ala Phe Arg Arg Gln Arg Leu 
            820                 825                 830         


Lys Pro Glu Ile Gln Cys Val Ser Ala Lys Ser Pro Gln His Cys Met 
        835                 840                 845             


Glu Arg Ile Gln Ala Glu Gln Val Asp Ala Val Thr Leu Ser Gly Glu 
    850                 855                 860                 


Asp Ile Tyr Thr Ala Gly Lys Thr Tyr Gly Leu Val Pro Ala Ala Gly 
865                 870                 875                 880 


Glu His Tyr Ala Pro Glu Asp Ser Ser Asn Ser Tyr Tyr Val Val Ala 
                885                 890                 895     


Val Val Arg Arg Asp Ser Ser His Ala Phe Thr Leu Asp Glu Leu Arg 
            900                 905                 910         


Gly Lys Arg Ser Cys His Ala Gly Phe Gly Ser Pro Ala Gly Trp Asp 
        915                 920                 925             


Val Pro Val Gly Ala Leu Ile Gln Arg Gly Phe Ile Arg Pro Lys Asp 
    930                 935                 940                 


Cys Asp Val Leu Thr Ala Val Ser Glu Phe Phe Asn Ala Ser Cys Val 
945                 950                 955                 960 


Pro Val Asn Asn Pro Lys Asn Tyr Pro Ser Ser Leu Cys Ala Leu Cys 
                965                 970                 975     


Val Gly Asp Glu Gln Gly Arg Asn Lys Cys Val Gly Asn Ser Gln Glu 
            980                 985                 990         


Arg Tyr Tyr Gly Tyr Arg Gly Ala  Phe Arg Cys Leu Val  Glu Asn Ala 
        995                 1000                 1005             


Gly Asp  Val Ala Phe Val Arg  His Thr Thr Val Phe  Asp Asn Thr 
    1010                 1015                 1020             


Asn Gly  His Asn Ser Glu Pro  Trp Ala Ala Glu Leu  Arg Ser Glu 
    1025                 1030                 1035             


Asp Tyr  Glu Leu Leu Cys Pro  Asn Gly Ala Arg Ala  Glu Val Ser 
    1040                 1045                 1050             


Gln Phe  Ala Ala Cys Asn Leu  Ala Gln Ile Pro Pro  His Ala Val 
    1055                 1060                 1065             


Met Val  Arg Pro Asp Thr Asn  Ile Phe Thr Val Tyr  Gly Leu Leu 
    1070                 1075                 1080             


Asp Lys  Ala Gln Asp Leu Phe  Gly Asp Asp His Asn  Lys Asn Gly 
    1085                 1090                 1095             


Phe Lys  Met Phe Asp Ser Ser  Asn Tyr His Gly Gln  Asp Leu Leu 
    1100                 1105                 1110             


Phe Lys  Asp Ala Thr Val Arg  Ala Val Pro Val Gly  Glu Lys Thr 
    1115                 1120                 1125             


Thr Tyr  Arg Gly Trp Leu Gly  Leu Asp Tyr Val Ala  Ala Leu Glu 
    1130                 1135                 1140             


Gly Met  Ser Ser Gln Gln Cys  Ser 
    1145                 1150     


<210>  97
<211>  1157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TZM heavy chain - linker - p97 fusion protein

<400>  97

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    450                 455                 460                 


Ser Gly Met Glu Val Arg Trp Cys Ala Thr Ser Asp Pro Glu Gln His 
465                 470                 475                 480 


Lys Cys Gly Asn Met Ser Glu Ala Phe Arg Glu Ala Gly Ile Gln Pro 
                485                 490                 495     


Ser Leu Leu Cys Val Arg Gly Thr Ser Ala Asp His Cys Val Gln Leu 
            500                 505                 510         


Ile Ala Ala Gln Glu Ala Asp Ala Ile Thr Leu Asp Gly Gly Ala Ile 
        515                 520                 525             


Tyr Glu Ala Gly Lys Glu His Gly Leu Lys Pro Val Val Gly Glu Val 
    530                 535                 540                 


Tyr Asp Gln Glu Val Gly Thr Ser Tyr Tyr Ala Val Ala Val Val Arg 
545                 550                 555                 560 


Arg Ser Ser His Val Thr Ile Asp Thr Leu Lys Gly Val Lys Ser Cys 
                565                 570                 575     


His Thr Gly Ile Asn Arg Thr Val Gly Trp Asn Val Pro Val Gly Tyr 
            580                 585                 590         


Leu Val Glu Ser Gly Arg Leu Ser Val Met Gly Cys Asp Val Leu Lys 
        595                 600                 605             


Ala Val Ser Asp Tyr Phe Gly Gly Ser Cys Val Pro Gly Ala Gly Glu 
    610                 615                 620                 


Thr Ser Tyr Ser Glu Ser Leu Cys Arg Leu Cys Arg Gly Asp Ser Ser 
625                 630                 635                 640 


Gly Glu Gly Val Cys Asp Lys Ser Pro Leu Glu Arg Tyr Tyr Asp Tyr 
                645                 650                 655     


Ser Gly Ala Phe Arg Cys Leu Ala Glu Gly Ala Gly Asp Val Ala Phe 
            660                 665                 670         


Val Lys His Ser Thr Val Leu Glu Asn Thr Asp Gly Lys Thr Leu Pro 
        675                 680                 685             


Ser Trp Gly Gln Ala Leu Leu Ser Gln Asp Phe Glu Leu Leu Cys Arg 
    690                 695                 700                 


Asp Gly Ser Arg Ala Asp Val Thr Glu Trp Arg Gln Cys His Leu Ala 
705                 710                 715                 720 


Arg Val Pro Ala His Ala Val Val Val Arg Ala Asp Thr Asp Gly Gly 
                725                 730                 735     


Leu Ile Phe Arg Leu Leu Asn Glu Gly Gln Arg Leu Phe Ser His Glu 
            740                 745                 750         


Gly Ser Ser Phe Gln Met Phe Ser Ser Glu Ala Tyr Gly Gln Lys Asp 
        755                 760                 765             


Leu Leu Phe Lys Asp Ser Thr Ser Glu Leu Val Pro Ile Ala Thr Gln 
    770                 775                 780                 


Thr Tyr Glu Ala Trp Leu Gly His Glu Tyr Leu His Ala Met Lys Gly 
785                 790                 795                 800 


Leu Leu Cys Asp Pro Asn Arg Leu Pro Pro Tyr Leu Arg Trp Cys Val 
                805                 810                 815     


Leu Ser Thr Pro Glu Ile Gln Lys Cys Gly Asp Met Ala Val Ala Phe 
            820                 825                 830         


Arg Arg Gln Arg Leu Lys Pro Glu Ile Gln Cys Val Ser Ala Lys Ser 
        835                 840                 845             


Pro Gln His Cys Met Glu Arg Ile Gln Ala Glu Gln Val Asp Ala Val 
    850                 855                 860                 


Thr Leu Ser Gly Glu Asp Ile Tyr Thr Ala Gly Lys Thr Tyr Gly Leu 
865                 870                 875                 880 


Val Pro Ala Ala Gly Glu His Tyr Ala Pro Glu Asp Ser Ser Asn Ser 
                885                 890                 895     


Tyr Tyr Val Val Ala Val Val Arg Arg Asp Ser Ser His Ala Phe Thr 
            900                 905                 910         


Leu Asp Glu Leu Arg Gly Lys Arg Ser Cys His Ala Gly Phe Gly Ser 
        915                 920                 925             


Pro Ala Gly Trp Asp Val Pro Val Gly Ala Leu Ile Gln Arg Gly Phe 
    930                 935                 940                 


Ile Arg Pro Lys Asp Cys Asp Val Leu Thr Ala Val Ser Glu Phe Phe 
945                 950                 955                 960 


Asn Ala Ser Cys Val Pro Val Asn Asn Pro Lys Asn Tyr Pro Ser Ser 
                965                 970                 975     


Leu Cys Ala Leu Cys Val Gly Asp Glu Gln Gly Arg Asn Lys Cys Val 
            980                 985                 990         


Gly Asn Ser Gln Glu Arg Tyr Tyr  Gly Tyr Arg Gly Ala  Phe Arg Cys 
        995                 1000                 1005             


Leu Val  Glu Asn Ala Gly Asp  Val Ala Phe Val Arg  His Thr Thr 
    1010                 1015                 1020             


Val Phe  Asp Asn Thr Asn Gly  His Asn Ser Glu Pro  Trp Ala Ala 
    1025                 1030                 1035             


Glu Leu  Arg Ser Glu Asp Tyr  Glu Leu Leu Cys Pro  Asn Gly Ala 
    1040                 1045                 1050             


Arg Ala  Glu Val Ser Gln Phe  Ala Ala Cys Asn Leu  Ala Gln Ile 
    1055                 1060                 1065             


Pro Pro  His Ala Val Met Val  Arg Pro Asp Thr Asn  Ile Phe Thr 
    1070                 1075                 1080             


Val Tyr  Gly Leu Leu Asp Lys  Ala Gln Asp Leu Phe  Gly Asp Asp 
    1085                 1090                 1095             


His Asn  Lys Asn Gly Phe Lys  Met Phe Asp Ser Ser  Asn Tyr His 
    1100                 1105                 1110             


Gly Gln  Asp Leu Leu Phe Lys  Asp Ala Thr Val Arg  Ala Val Pro 
    1115                 1120                 1125             


Val Gly  Glu Lys Thr Thr Tyr  Arg Gly Trp Leu Gly  Leu Asp Tyr 
    1130                 1135                 1140             


Val Ala  Ala Leu Glu Gly Met  Ser Ser Gln Gln Cys  Ser Gly 
    1145                 1150                 1155         


<210>  98
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  p97 fragment - linker - TZM heavy chain fusion protein

<400>  98

Asp Ser Ser His Ala Phe Thr Leu Asp Glu Leu Arg Tyr Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
            20                  25                  30          


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        35                  40                  45              


Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr 
65                  70                  75                  80  


Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp 
                85                  90                  95      


Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
            100                 105                 110         


Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr 
        115                 120                 125             


Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
    130                 135                 140                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
145                 150                 155                 160 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
    210                 215                 220                 


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
225                 230                 235                 240 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470             


<210>  99
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  p97 fragment - linker - TZM heavy chain fusion protein

<400>  99

Asp Ser Ser His Ala Phe Thr Leu Asp Glu Leu Arg Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr 
65                  70                  75                  80  


Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr 
                85                  90                  95      


Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala 
        115                 120                 125             


Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
145                 150                 155                 160 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 175     


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        195                 200                 205             


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
    210                 215                 220                 


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
225                 230                 235                 240 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                245                 250                 255     


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    370                 375                 380                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 


Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470         


<210>  100
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  p97 fragment - linker - TZM heavy chain fusion protein

<400>  100

Asp Ser Ser His Ala Phe Thr Leu Asp Glu Leu Arg Tyr Glu Ala Ala 
1               5                   10                  15      


Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Val Gln Leu 
            20                  25                  30          


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
        35                  40                  45              


Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp 
    50                  55                  60                  


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr 
65                  70                  75                  80  


Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe 
                85                  90                  95      


Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn 
            100                 105                 110         


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly 
        115                 120                 125             


Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
    130                 135                 140                 


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
145                 150                 155                 160 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
                165                 170                 175     


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
            180                 185                 190         


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
        195                 200                 205             


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
    210                 215                 220                 


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
225                 230                 235                 240 


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
                245                 250                 255     


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
            260                 265                 270         


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
        275                 280                 285             


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
    290                 295                 300                 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
305                 310                 315                 320 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
                325                 330                 335     


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
            340                 345                 350         


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
        355                 360                 365             


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    370                 375                 380                 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
385                 390                 395                 400 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                405                 410                 415     


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
            420                 425                 430         


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
        435                 440                 445             


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    450                 455                 460                 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475             


<210>  101
<211>  477
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  p97 fragment - linker - TZM heavy chain fusion protein

<400>  101

Asp Ser Ser His Ala Phe Thr Leu Asp Glu Leu Arg Glu Ala Ala Ala 
1               5                   10                  15      


Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Val Gln Leu Val 
            20                  25                  30          


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
        35                  40                  45              


Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val 
    50                  55                  60                  


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro 
65                  70                  75                  80  


Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
                85                  90                  95      


Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser 
            100                 105                 110         


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly 
        115                 120                 125             


Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
    130                 135                 140                 


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
145                 150                 155                 160 


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
                165                 170                 175     


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
            180                 185                 190         


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
        195                 200                 205             


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
    210                 215                 220                 


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
225                 230                 235                 240 


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
                245                 250                 255     


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            260                 265                 270         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        275                 280                 285             


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    290                 295                 300                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
305                 310                 315                 320 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                325                 330                 335     


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            340                 345                 350         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        355                 360                 365             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    370                 375                 380                 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
385                 390                 395                 400 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                405                 410                 415     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            420                 425                 430         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        435                 440                 445             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    450                 455                 460                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475         


<210>  102
<211>  463
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  p97 fragment - TZM heavy chain fusion protein

<400>  102

Asp Ser Ser His Ala Phe Thr Leu Asp Glu Leu Arg Tyr Glu Val Gln 
1               5                   10                  15      


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
            20                  25                  30          


Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His 
        35                  40                  45              


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile 
    50                  55                  60                  


Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg 
65                  70                  75                  80  


Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met 
                85                  90                  95      


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp 
            100                 105                 110         


Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
    130                 135                 140                 


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
145                 150                 155                 160 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
                165                 170                 175     


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
            180                 185                 190         


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
        195                 200                 205             


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
    210                 215                 220                 


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
225                 230                 235                 240 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460             


<210>  103
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  p97 fragment - TZM heavy chain fusion protein

<400>  103

Asp Ser Ser His Ala Phe Thr Leu Asp Glu Leu Arg Glu Val Gln Leu 
1               5                   10                  15      


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
            20                  25                  30          


Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp 
        35                  40                  45              


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr 
    50                  55                  60                  


Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe 
65                  70                  75                  80  


Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn 
                85                  90                  95      


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly 
            100                 105                 110         


Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        195                 200                 205             


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
225                 230                 235                 240 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
                245                 250                 255     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            260                 265                 270         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        275                 280                 285             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    290                 295                 300                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
305                 310                 315                 320 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                325                 330                 335     


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        355                 360                 365             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    370                 375                 380                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
385                 390                 395                 400 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                405                 410                 415     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            420                 425                 430         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        435                 440                 445             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460         


<210>  104
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TZM heavy chain - linker - p97 fragment fusion protein

<400>  104

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ser Ser His 
    450                 455                 460                 


Ala Phe Thr Leu Asp Glu Leu Arg 
465                 470         


<210>  105
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TZM heavy chain - linker - p97 fragment fusion protein

<400>  105

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ser Ser His 
    450                 455                 460                 


Ala Phe Thr Leu Asp Glu Leu Arg Tyr 
465                 470             


<210>  106
<211>  479
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TZM heavy chain - linker - p97 fragment fusion protein

<400>  106

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala 
    450                 455                 460                 


Ala Lys Asp Ser Ser His Ala Phe Thr Leu Asp Glu Leu Arg Tyr 
465                 470                 475                 


<210>  107
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TZM heavy chain - linker - p97 fragment fusion protein

<400>  107

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala 
    450                 455                 460                 


Ala Lys Asp Ser Ser His Ala Phe Thr Leu Asp Glu Leu Arg 
465                 470                 475             


<210>  108
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TZM heavy chain - p97 fragment fusion protein

<400>  108

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys Asp Ser Ser His Ala Phe Thr Leu Asp Glu Leu Arg 
    450                 455                 460         


<210>  109
<211>  463
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TZM heavy chain - p97 fragment fusion protein

<400>  109

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys Asp Ser Ser His Ala Phe Thr Leu Asp Glu Leu Arg Tyr 
    450                 455                 460             


<210>  110
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab FL light chain - p97 fragment fusion protein

<400>  110

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Asp Ser Ser His Ala Phe Thr Leu Asp Glu 
    210                 215                 220                 


Leu Arg Tyr 
225         


<210>  111
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab FL light chain - linker - p97 fragment fusion protein

<400>  111

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
    210                 215                 220                 


Glu Ala Ala Ala Lys Asp Ser Ser His Ala Phe Thr Leu Asp Glu Leu 
225                 230                 235                 240 


Arg Tyr 
        


<210>  112
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab FL light chain - linker - p97 fragment fusion protein

<400>  112

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    210                 215                 220                 


Asp Ser Ser His Ala Phe Thr Leu Asp Glu Leu Arg Tyr 
225                 230                 235         


<210>  113
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab FL light chain - p97 fragment fusion protein

<400>  113

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Asp Ser Ser His Ala Phe Thr Leu Asp Glu 
    210                 215                 220                 


Leu Arg 
225     


<210>  114
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab FL light chain - linker - p97 fragment fusion protein

<400>  114

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
    210                 215                 220                 


Glu Ala Ala Ala Lys Asp Ser Ser His Ala Phe Thr Leu Asp Glu Leu 
225                 230                 235                 240 


Arg 
    


<210>  115
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab FL light chain - linker - p97 fragment fusion protein

<400>  115

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    210                 215                 220                 


Asp Ser Ser His Ala Phe Thr Leu Asp Glu Leu Arg Tyr 
225                 230                 235         


<210>  116
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  p97 fragment - Trastuzumab FL light chain  fusion protein

<400>  116

Asp Ser Ser His Ala Phe Thr Leu Asp Glu Leu Arg Tyr Asp Ile Gln 
1               5                   10                  15      


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
            20                  25                  30          


Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp 
        35                  40                  45              


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala 
    50                  55                  60                  


Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser 
65                  70                  75                  80  


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
                85                  90                  95      


Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly 
            100                 105                 110         


Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val 
        115                 120                 125             


Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser 
    130                 135                 140                 


Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln 
145                 150                 155                 160 


Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val 
                165                 170                 175     


Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu 
            180                 185                 190         


Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu 
        195                 200                 205             


Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg 
    210                 215                 220                 


Gly Glu Cys 
225         


<210>  117
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  p97 fragment - linker - Trastuzumab FL light chain  fusion 
       protein

<400>  117

Asp Ser Ser His Ala Phe Thr Leu Asp Glu Leu Arg Tyr Glu Ala Ala 
1               5                   10                  15      


Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Asp Ile Gln Met 
            20                  25                  30          


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
        35                  40                  45              


Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr 
    50                  55                  60                  


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser 
65                  70                  75                  80  


Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly 
                85                  90                  95      


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            100                 105                 110         


Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln 
        115                 120                 125             


Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe 
    130                 135                 140                 


Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val 
145                 150                 155                 160 


Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp 
                165                 170                 175     


Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr 
            180                 185                 190         


Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr 
        195                 200                 205             


Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val 
    210                 215                 220                 


Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly 
225                 230                 235                 240 


Glu Cys 
        


<210>  118
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  p97 fragment - linker - Trastuzumab FL light chain  fusion 
       protein

<400>  118

Asp Ser Ser His Ala Phe Thr Leu Asp Glu Leu Arg Tyr Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
            20                  25                  30          


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
        35                  40                  45              


Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu 
        115                 120                 125             


Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 
    130                 135                 140                 


Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn 
145                 150                 155                 160 


Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 
                165                 170                 175     


Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 
            180                 185                 190         


Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 
        195                 200                 205             


Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 
    210                 215                 220                 


Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235         


<210>  119
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  p97 fragment - Trastuzumab FL light chain  fusion protein

<400>  119

Asp Ser Ser His Ala Phe Thr Leu Asp Glu Leu Arg Asp Ile Gln Met 
1               5                   10                  15      


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
            20                  25                  30          


Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr 
        35                  40                  45              


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser 
    50                  55                  60                  


Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly 
65                  70                  75                  80  


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
                85                  90                  95      


Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln 
            100                 105                 110         


Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe 
        115                 120                 125             


Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val 
    130                 135                 140                 


Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp 
145                 150                 155                 160 


Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr 
                165                 170                 175     


Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr 
            180                 185                 190         


Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val 
        195                 200                 205             


Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly 
    210                 215                 220                 


Glu Cys 
225     


<210>  120
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  p97 fragment - linker - Trastuzumab FL light chain  fusion 
       protein

<400>  120

Asp Ser Ser His Ala Phe Thr Leu Asp Glu Leu Arg Glu Ala Ala Ala 
1               5                   10                  15      


Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Asp Ile Gln Met Thr 
            20                  25                  30          


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        35                  40                  45              


Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln 
    50                  55                  60                  


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe 
65                  70                  75                  80  


Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr 
                85                  90                  95      


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
            100                 105                 110         


Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly 
        115                 120                 125             


Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile 
    130                 135                 140                 


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
145                 150                 155                 160 


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
                165                 170                 175     


Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu 
            180                 185                 190         


Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu 
        195                 200                 205             


Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr 
    210                 215                 220                 


His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
225                 230                 235                 240 


Cys 
    


<210>  121
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  p97 fragment - linker - Trastuzumab FL light chain  fusion 
       protein

<400>  121

Asp Ser Ser His Ala Phe Thr Leu Asp Glu Leu Arg Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  122
<211>  471
<212>  PRT
<213>  Homo sapiens

<400>  122

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn 
        35                  40                  45              


Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys 
                85                  90                  95      


Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys 
465                 470     


<210>  123
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  123

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr 
            100                 105                 110         


Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  124
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker peptide

<400>  124

Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15  


<210>  125
<211>  3519
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TZM HC-MTf fusion protein polynucleotide

<400>  125
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gaggtgcagc tggtggagag cggcggaggc ctcgtgcagc ccggcggatc tctgcggctg      120

agctgcgccg ctagcggctt caacatcaag gacacctaca tccactgggt gcgccaggcc      180

cccggcaagg gcctggagtg ggtggcccgg atctacccca ccaacggcta cacccgctac      240

gccgacagcg tgaagggccg gttcaccatc agcgccgaca cctccaagaa caccgcctac      300

ctgcagatga acagcctgcg cgccgaggac accgccgtgt actactgcag ccggtggggc      360

ggcgacggat tctacgccat ggactactgg ggacagggca ccctggtgac cgtgagcagc      420

gcctctacca agggccccag cgtgttccct ctggccccca gcagcaagag caccagcggc      480

ggaaccgccg ccctgggctg cctggtgaag gactacttcc ccgagcccgt gaccgtgtcc      540

tggaacagcg gcgctctgac cagcggagtg cacaccttcc ctgccgtgct gcagagcagc      600

ggcctgtact ccctgagcag cgtggtgacc gtgcccagca gcagcctggg cacccagacc      660

tacatctgca acgtgaacca caagccctcc aacaccaagg tggacaagaa ggtggagcct      720

aagagctgcg acaagaccca cacctgccct ccctgccccg cccccgagct gctgggcgga      780

cccagcgtgt tcctgttccc tcccaagccc aaggacaccc tgatgatcag ccgcaccccc      840

gaggtgacct gcgtggtggt ggacgtgagc cacgaggacc ccgaggtgaa gttcaactgg      900

tacgtggacg gcgtggaggt gcacaacgcc aagaccaagc ctcgggagga gcagtacaac      960

tccacctacc gcgtggtgag cgtgctgacc gtgctgcacc aggactggct gaacggcaag     1020

gagtacaagt gcaaggtgag caacaaggcc ctgcccgctc ccatcgagaa gaccatcagc     1080

aaggccaagg gccagccccg ggagcctcag gtgtacaccc tgccccccag ccgcgacgag     1140

ctgaccaaga accaggtgag cctgacctgc ctggtgaagg gcttctaccc ctccgacatc     1200

gccgtggagt gggagagcaa cggccagcct gagaacaact acaagaccac ccctcccgtg     1260

ctggacagcg acggcagctt cttcctgtac agcaagctga ccgtggacaa gtcccggtgg     1320

cagcagggca acgtgttcag ctgcagcgtg atgcacgagg ccctgcacaa ccactacacc     1380

cagaagagcc tgagcctgag ccccggaaag ggtggcggag gatctggcgg aggcggatcc     1440

ggcatggaag tgcgttggtg cgccacctct gaccccgagc agcacaagtg cggcaacatg     1500

tccgaggcct tcagagaggc cggcatccag ccttctctgc tgtgtgtgcg gggcacctct     1560

gccgaccatt gcgtgcagct gatcgccgcc caggaagccg acgctatcac actggatggc     1620

ggcgctatct acgaggctgg caaagagcac ggcctgaagc ccgtcgtggg cgaggtgtac     1680

gatcaggaag tgggcacctc ctactacgcc gtggctgtcg tgcggagatc ctcccacgtg     1740

accatcgaca ccctgaaggg cgtgaagtcc tgccacaccg gcatcaacag aaccgtgggc     1800

tggaacgtgc ccgtgggcta cctggtggaa tccggcagac tgtccgtgat gggctgcgac     1860

gtgctgaagg ccgtgtccga ttacttcggc ggctcttgtg tgcctggcgc tggcgagaca     1920

tcctactccg agtccctgtg cagactgtgc aggggcgact cttctggcga gggcgtgtgc     1980

gacaagtccc ctctggaacg gtactacgac tactccggcg ccttcagatg cctggctgaa     2040

ggtgctggcg acgtggcctt cgtgaagcac tccaccgtgc tggaaaacac cgacggcaag     2100

accctgcctt cttggggcca ggcactgctg tcccaggact tcgagctgct gtgccgggat     2160

ggctccagag ccgatgtgac agagtggcgg cagtgccacc tggccagagt gcctgcccat     2220

gctgtggtcg tgcgcgccga tacagatggc ggcctgatct tccggctgct gaacgagggc     2280

cagcggctgt tctctcacga gggctccagc ttccagatgt tctccagcga ggcctacggc     2340

cagaaggacc tgctgttcaa ggactccacc tccgagctgg tgcctatcgc cacccagacc     2400

tatgaggctt ggctgggcca cgagtacctg cacgctatga agggactgct gtgcgacccc     2460

aaccggctgc ctccttatct gaggtggtgc gtgctgtcca cccccgagat ccagaaatgc     2520

ggcgatatgg ccgtggcctt tcggcggcag agactgaagc ctgagatcca gtgcgtgtct     2580

gccaagagcc ctcagcactg catggaacgg atccaggccg aacaggtgga cgccgtgaca     2640

ctgtccggcg aggatatcta caccgccgga aagacctacg gcctggtgcc agctgctggc     2700

gagcattacg cccctgagga ctcctccaac agctactacg tggtggcagt cgtgcgccgg     2760

gactcctctc acgcctttac cctggatgag ctgcggggca agagaagctg tcacgccggc     2820

tttggaagcc ctgccggatg ggatgtgcct gtgggcgctc tgatccagcg gggcttcatc     2880

agacccaagg actgtgatgt gctgaccgcc gtgtctgagt tcttcaacgc ctcctgtgtg     2940

cccgtgaaca accccaagaa ctacccctcc agcctgtgcg ccctgtgtgt gggagatgag     3000

cagggccgga acaaatgcgt gggcaactcc caggaaagat attacggcta cagaggcgcc     3060

ttccggtgtc tggtggaaaa cgccggggat gtggcttttg tgcggcacac caccgtgttc     3120

gacaacacca atggccacaa ctccgagcct tgggccgctg agctgagatc cgaggattac     3180

gaactgctgt gtcccaacgg cgccagggct gaggtgtccc agtttgccgc ctgtaacctg     3240

gcccagatcc ctccccacgc tgtgatggtg cgacccgaca ccaacatctt caccgtgtac     3300

ggcctgctgg acaaggccca ggatctgttc ggcgacgacc acaacaagaa cgggttcaag     3360

atgttcgact ccagcaacta ccacggacag gatctgctgt ttaaagatgc caccgtgcgg     3420

gccgtgccag tgggcgaaaa gaccacctac agaggatggc tgggactgga ctacgtggcc     3480

gccctggaag gcatgtcctc ccagcagtgt tccggctag                            3519


<210>  126
<211>  705
<212>  DNA
<213>  Homo sapiens

<400>  126
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag cccttccagc ctgagcgcca gcgtgggcga ccgggtgacc      120

atcacctgcc gcgctagcca ggacgtgaac accgccgtgg cctggtacca gcagaagccc      180

ggaaaggccc ccaagctgct gatctactct gctagcttcc tgtacagcgg cgtgcccagc      240

cggttcagcg gatctcgcag cggcaccgac ttcaccctga ccatcagcag cctgcagcct      300

gaggacttcg ccacctacta ctgccagcag cactacacca cgcctcccac cttcggacag      360

ggcaccaagg tggagatcaa gcggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  127
<211>  1482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MTfp NH-TZM fusion protein polynucleotide

<400>  127
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gactcctctc acgccttcac cctggacgag ctgcggtacg gtggcggagg atctggcgga      120

ggcggatccg aggtgcagct ggtggagagc ggcggaggcc tcgtgcagcc cggcggatct      180

ctgcggctga gctgcgccgc tagcggcttc aacatcaagg acacctacat ccactgggtg      240

cgccaggccc ccggcaaggg cctggagtgg gtggcccgga tctaccccac caacggctac      300

acccgctacg ccgacagcgt gaagggccgg ttcaccatca gcgccgacac ctccaagaac      360

accgcctacc tgcagatgaa cagcctgcgc gccgaggaca ccgccgtgta ctactgcagc      420

cggtggggcg gcgacggatt ctacgccatg gactactggg gacagggcac cctggtgacc      480

gtgagcagcg cctctaccaa gggccccagc gtgttccctc tggcccccag cagcaagagc      540

accagcggcg gaaccgccgc cctgggctgc ctggtgaagg actacttccc cgagcccgtg      600

accgtgtcct ggaacagcgg cgctctgacc agcggagtgc acaccttccc tgccgtgctg      660

cagagcagcg gcctgtactc cctgagcagc gtggtgaccg tgcccagcag cagcctgggc      720

acccagacct acatctgcaa cgtgaaccac aagccctcca acaccaaggt ggacaagaag      780

gtggagccta agagctgcga caagacccac acctgccctc cctgccccgc ccccgagctg      840

ctgggcggac ccagcgtgtt cctgttccct cccaagccca aggacaccct gatgatcagc      900

cgcacccccg aggtgacctg cgtggtggtg gacgtgagcc acgaggaccc cgaggtgaag      960

ttcaactggt acgtggacgg cgtggaggtg cacaacgcca agaccaagcc tcgggaggag     1020

cagtacaact ccacctaccg cgtggtgagc gtgctgaccg tgctgcacca ggactggctg     1080

aacggcaagg agtacaagtg caaggtgagc aacaaggccc tgcccgctcc catcgagaag     1140

accatcagca aggccaaggg ccagccccgg gagcctcagg tgtacaccct gccccccagc     1200

cgcgacgagc tgaccaagaa ccaggtgagc ctgacctgcc tggtgaaggg cttctacccc     1260

tccgacatcg ccgtggagtg ggagagcaac ggccagcctg agaacaacta caagaccacc     1320

cctcccgtgc tggacagcga cggcagcttc ttcctgtaca gcaagctgac cgtggacaag     1380

tcccggtggc agcagggcaa cgtgttcagc tgcagcgtga tgcacgaggc cctgcacaac     1440

cactacaccc agaagagcct gagcctgagc cccggaaagt aa                        1482


<210>  128
<211>  705
<212>  DNA
<213>  Homo sapiens

<400>  128
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag cccttccagc ctgagcgcca gcgtgggcga ccgggtgacc      120

atcacctgcc gcgctagcca ggacgtgaac accgccgtgg cctggtacca gcagaagccc      180

ggaaaggccc ccaagctgct gatctactct gctagcttcc tgtacagcgg cgtgcccagc      240

cggttcagcg gatctcgcag cggcaccgac ttcaccctga ccatcagcag cctgcagcct      300

gaggacttcg ccacctacta ctgccagcag cactacacca cgcctcccac cttcggacag      360

ggcaccaagg tggagatcaa gcggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  129
<211>  1479
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TZM HC-MTfp fusion protein polynucleotid

<400>  129

Ala Thr Gly Gly Ala Gly Ala Cys Cys Gly Ala Cys Ala Cys Cys Cys 
1               5                   10                  15      


Thr Gly Cys Thr Gly Cys Thr Cys Thr Gly Gly Gly Thr Gly Cys Thr 
            20                  25                  30          


Gly Cys Thr Gly Cys Thr Cys Thr Gly Gly Gly Thr Gly Cys Cys Cys 
        35                  40                  45              


Gly Gly Cys Thr Cys Cys Ala Cys Cys Gly Gly Ala Gly Ala Gly Gly 
    50                  55                  60                  


Thr Gly Cys Ala Gly Cys Thr Gly Gly Thr Gly Gly Ala Gly Ala Gly 
65                  70                  75                  80  


Cys Gly Gly Cys Gly Gly Ala Gly Gly Cys Cys Thr Cys Gly Thr Gly 
                85                  90                  95      


Cys Ala Gly Cys Cys Cys Gly Gly Cys Gly Gly Ala Thr Cys Thr Cys 
            100                 105                 110         


Thr Gly Cys Gly Gly Cys Thr Gly Ala Gly Cys Thr Gly Cys Gly Cys 
        115                 120                 125             


Cys Gly Cys Thr Ala Gly Cys Gly Gly Cys Thr Thr Cys Ala Ala Cys 
    130                 135                 140                 


Ala Thr Cys Ala Ala Gly Gly Ala Cys Ala Cys Cys Thr Ala Cys Ala 
145                 150                 155                 160 


Thr Cys Cys Ala Cys Thr Gly Gly Gly Thr Gly Cys Gly Cys Cys Ala 
                165                 170                 175     


Gly Gly Cys Cys Cys Cys Cys Gly Gly Cys Ala Ala Gly Gly Gly Cys 
            180                 185                 190         


Cys Thr Gly Gly Ala Gly Thr Gly Gly Gly Thr Gly Gly Cys Cys Cys 
        195                 200                 205             


Gly Gly Ala Thr Cys Thr Ala Cys Cys Cys Cys Ala Cys Cys Ala Ala 
    210                 215                 220                 


Cys Gly Gly Cys Thr Ala Cys Ala Cys Cys Cys Gly Cys Thr Ala Cys 
225                 230                 235                 240 


Gly Cys Cys Gly Ala Cys Ala Gly Cys Gly Thr Gly Ala Ala Gly Gly 
                245                 250                 255     


Gly Cys Cys Gly Gly Thr Thr Cys Ala Cys Cys Ala Thr Cys Ala Gly 
            260                 265                 270         


Cys Gly Cys Cys Gly Ala Cys Ala Cys Cys Thr Cys Cys Ala Ala Gly 
        275                 280                 285             


Ala Ala Cys Ala Cys Cys Gly Cys Cys Thr Ala Cys Cys Thr Gly Cys 
    290                 295                 300                 


Ala Gly Ala Thr Gly Ala Ala Cys Ala Gly Cys Cys Thr Gly Cys Gly 
305                 310                 315                 320 


Cys Gly Cys Cys Gly Ala Gly Gly Ala Cys Ala Cys Cys Gly Cys Cys 
                325                 330                 335     


Gly Thr Gly Thr Ala Cys Thr Ala Cys Thr Gly Cys Ala Gly Cys Cys 
            340                 345                 350         


Gly Gly Thr Gly Gly Gly Gly Cys Gly Gly Cys Gly Ala Cys Gly Gly 
        355                 360                 365             


Ala Thr Thr Cys Thr Ala Cys Gly Cys Cys Ala Thr Gly Gly Ala Cys 
    370                 375                 380                 


Thr Ala Cys Thr Gly Gly Gly Gly Ala Cys Ala Gly Gly Gly Cys Ala 
385                 390                 395                 400 


Cys Cys Cys Thr Gly Gly Thr Gly Ala Cys Cys Gly Thr Gly Ala Gly 
                405                 410                 415     


Cys Ala Gly Cys Gly Cys Cys Thr Cys Thr Ala Cys Cys Ala Ala Gly 
            420                 425                 430         


Gly Gly Cys Cys Cys Cys Ala Gly Cys Gly Thr Gly Thr Thr Cys Cys 
        435                 440                 445             


Cys Thr Cys Thr Gly Gly Cys Cys Cys Cys Cys Ala Gly Cys Ala Gly 
    450                 455                 460                 


Cys Ala Ala Gly Ala Gly Cys Ala Cys Cys Ala Gly Cys Gly Gly Cys 
465                 470                 475                 480 


Gly Gly Ala Ala Cys Cys Gly Cys Cys Gly Cys Cys Cys Thr Gly Gly 
                485                 490                 495     


Gly Cys Thr Gly Cys Cys Thr Gly Gly Thr Gly Ala Ala Gly Gly Ala 
            500                 505                 510         


Cys Thr Ala Cys Thr Thr Cys Cys Cys Cys Gly Ala Gly Cys Cys Cys 
        515                 520                 525             


Gly Thr Gly Ala Cys Cys Gly Thr Gly Thr Cys Cys Thr Gly Gly Ala 
    530                 535                 540                 


Ala Cys Ala Gly Cys Gly Gly Cys Gly Cys Thr Cys Thr Gly Ala Cys 
545                 550                 555                 560 


Cys Ala Gly Cys Gly Gly Ala Gly Thr Gly Cys Ala Cys Ala Cys Cys 
                565                 570                 575     


Thr Thr Cys Cys Cys Thr Gly Cys Cys Gly Thr Gly Cys Thr Gly Cys 
            580                 585                 590         


Ala Gly Ala Gly Cys Ala Gly Cys Gly Gly Cys Cys Thr Gly Thr Ala 
        595                 600                 605             


Cys Thr Cys Cys Cys Thr Gly Ala Gly Cys Ala Gly Cys Gly Thr Gly 
    610                 615                 620                 


Gly Thr Gly Ala Cys Cys Gly Thr Gly Cys Cys Cys Ala Gly Cys Ala 
625                 630                 635                 640 


Gly Cys Ala Gly Cys Cys Thr Gly Gly Gly Cys Ala Cys Cys Cys Ala 
                645                 650                 655     


Gly Ala Cys Cys Thr Ala Cys Ala Thr Cys Thr Gly Cys Ala Ala Cys 
            660                 665                 670         


Gly Thr Gly Ala Ala Cys Cys Ala Cys Ala Ala Gly Cys Cys Cys Thr 
        675                 680                 685             


Cys Cys Ala Ala Cys Ala Cys Cys Ala Ala Gly Gly Thr Gly Gly Ala 
    690                 695                 700                 


Cys Ala Ala Gly Ala Ala Gly Gly Thr Gly Gly Ala Gly Cys Cys Thr 
705                 710                 715                 720 


Ala Ala Gly Ala Gly Cys Thr Gly Cys Gly Ala Cys Ala Ala Gly Ala 
                725                 730                 735     


Cys Cys Cys Ala Cys Ala Cys Cys Thr Gly Cys Cys Cys Thr Cys Cys 
            740                 745                 750         


Cys Thr Gly Cys Cys Cys Cys Gly Cys Cys Cys Cys Cys Gly Ala Gly 
        755                 760                 765             


Cys Thr Gly Cys Thr Gly Gly Gly Cys Gly Gly Ala Cys Cys Cys Ala 
    770                 775                 780                 


Gly Cys Gly Thr Gly Thr Thr Cys Cys Thr Gly Thr Thr Cys Cys Cys 
785                 790                 795                 800 


Thr Cys Cys Cys Ala Ala Gly Cys Cys Cys Ala Ala Gly Gly Ala Cys 
                805                 810                 815     


Ala Cys Cys Cys Thr Gly Ala Thr Gly Ala Thr Cys Ala Gly Cys Cys 
            820                 825                 830         


Gly Cys Ala Cys Cys Cys Cys Cys Gly Ala Gly Gly Thr Gly Ala Cys 
        835                 840                 845             


Cys Thr Gly Cys Gly Thr Gly Gly Thr Gly Gly Thr Gly Gly Ala Cys 
    850                 855                 860                 


Gly Thr Gly Ala Gly Cys Cys Ala Cys Gly Ala Gly Gly Ala Cys Cys 
865                 870                 875                 880 


Cys Cys Gly Ala Gly Gly Thr Gly Ala Ala Gly Thr Thr Cys Ala Ala 
                885                 890                 895     


Cys Thr Gly Gly Thr Ala Cys Gly Thr Gly Gly Ala Cys Gly Gly Cys 
            900                 905                 910         


Gly Thr Gly Gly Ala Gly Gly Thr Gly Cys Ala Cys Ala Ala Cys Gly 
        915                 920                 925             


Cys Cys Ala Ala Gly Ala Cys Cys Ala Ala Gly Cys Cys Thr Cys Gly 
    930                 935                 940                 


Gly Gly Ala Gly Gly Ala Gly Cys Ala Gly Thr Ala Cys Ala Ala Cys 
945                 950                 955                 960 


Thr Cys Cys Ala Cys Cys Thr Ala Cys Cys Gly Cys Gly Thr Gly Gly 
                965                 970                 975     


Thr Gly Ala Gly Cys Gly Thr Gly Cys Thr Gly Ala Cys Cys Gly Thr 
            980                 985                 990         


Gly Cys Thr Gly Cys Ala Cys Cys  Ala Gly Gly Ala Cys  Thr Gly Gly 
        995                 1000                 1005             


Cys Thr  Gly Ala Ala Cys Gly  Gly Cys Ala Ala Gly  Gly Ala Gly 
    1010                 1015                 1020             


Thr Ala  Cys Ala Ala Gly Thr  Gly Cys Ala Ala Gly  Gly Thr Gly 
    1025                 1030                 1035             


Ala Gly  Cys Ala Ala Cys Ala  Ala Gly Gly Cys Cys  Cys Thr Gly 
    1040                 1045                 1050             


Cys Cys  Cys Gly Cys Thr Cys  Cys Cys Ala Thr Cys  Gly Ala Gly 
    1055                 1060                 1065             


Ala Ala  Gly Ala Cys Cys Ala  Thr Cys Ala Gly Cys  Ala Ala Gly 
    1070                 1075                 1080             


Gly Cys  Cys Ala Ala Gly Gly  Gly Cys Cys Ala Gly  Cys Cys Cys 
    1085                 1090                 1095             


Cys Gly  Gly Gly Ala Gly Cys  Cys Thr Cys Ala Gly  Gly Thr Gly 
    1100                 1105                 1110             


Thr Ala  Cys Ala Cys Cys Cys  Thr Gly Cys Cys Cys  Cys Cys Cys 
    1115                 1120                 1125             


Ala Gly  Cys Cys Gly Cys Gly  Ala Cys Gly Ala Gly  Cys Thr Gly 
    1130                 1135                 1140             


Ala Cys  Cys Ala Ala Gly Ala  Ala Cys Cys Ala Gly  Gly Thr Gly 
    1145                 1150                 1155             


Ala Gly  Cys Cys Thr Gly Ala  Cys Cys Thr Gly Cys  Cys Thr Gly 
    1160                 1165                 1170             


Gly Thr  Gly Ala Ala Gly Gly  Gly Cys Thr Thr Cys  Thr Ala Cys 
    1175                 1180                 1185             


Cys Cys  Cys Thr Cys Cys Gly  Ala Cys Ala Thr Cys  Gly Cys Cys 
    1190                 1195                 1200             


Gly Thr  Gly Gly Ala Gly Thr  Gly Gly Gly Ala Gly  Ala Gly Cys 
    1205                 1210                 1215             


Ala Ala  Cys Gly Gly Cys Cys  Ala Gly Cys Cys Thr  Gly Ala Gly 
    1220                 1225                 1230             


Ala Ala  Cys Ala Ala Cys Thr  Ala Cys Ala Ala Gly  Ala Cys Cys 
    1235                 1240                 1245             


Ala Cys  Cys Cys Cys Thr Cys  Cys Cys Gly Thr Gly  Cys Thr Gly 
    1250                 1255                 1260             


Gly Ala  Cys Ala Gly Cys Gly  Ala Cys Gly Gly Cys  Ala Gly Cys 
    1265                 1270                 1275             


Thr Thr  Cys Thr Thr Cys Cys  Thr Gly Thr Ala Cys  Ala Gly Cys 
    1280                 1285                 1290             


Ala Ala  Gly Cys Thr Gly Ala  Cys Cys Gly Thr Gly  Gly Ala Cys 
    1295                 1300                 1305             


Ala Ala  Gly Thr Cys Cys Cys  Gly Gly Thr Gly Gly  Cys Ala Gly 
    1310                 1315                 1320             


Cys Ala  Gly Gly Gly Cys Ala  Ala Cys Gly Thr Gly  Thr Thr Cys 
    1325                 1330                 1335             


Ala Gly  Cys Thr Gly Cys Ala  Gly Cys Gly Thr Gly  Ala Thr Gly 
    1340                 1345                 1350             


Cys Ala  Cys Gly Ala Gly Gly  Cys Cys Cys Thr Gly  Cys Ala Cys 
    1355                 1360                 1365             


Ala Ala  Cys Cys Ala Cys Thr  Ala Cys Ala Cys Cys  Cys Ala Gly 
    1370                 1375                 1380             


Ala Ala  Gly Ala Gly Cys Cys  Thr Gly Ala Gly Cys  Cys Thr Gly 
    1385                 1390                 1395             


Ala Gly  Cys Cys Cys Cys Gly  Gly Ala Ala Ala Gly  Gly Gly Thr 
    1400                 1405                 1410             


Gly Gly  Cys Gly Gly Ala Gly  Gly Ala Thr Cys Thr  Gly Gly Cys 
    1415                 1420                 1425             


Gly Gly  Ala Gly Gly Cys Gly  Gly Ala Thr Cys Cys  Gly Ala Cys 
    1430                 1435                 1440             


Thr Cys  Cys Thr Cys Thr Cys  Ala Cys Gly Cys Cys  Thr Thr Cys 
    1445                 1450                 1455             


Ala Cys  Cys Cys Thr Gly Gly  Ala Cys Gly Ala Gly  Cys Thr Gly 
    1460                 1465                 1470             


Cys Gly  Gly Thr Ala Gly 
    1475                 


<210>  130
<211>  705
<212>  DNA
<213>  Homo sapiens

<400>  130
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag cccttccagc ctgagcgcca gcgtgggcga ccgggtgacc      120

atcacctgcc gcgctagcca ggacgtgaac accgccgtgg cctggtacca gcagaagccc      180

ggaaaggccc ccaagctgct gatctactct gctagcttcc tgtacagcgg cgtgcccagc      240

cggttcagcg gatctcgcag cggcaccgac ttcaccctga ccatcagcag cctgcagcct      300

gaggacttcg ccacctacta ctgccagcag cactacacca cgcctcccac cttcggacag      360

ggcaccaagg tggagatcaa gcggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  131
<211>  3534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TZM/MTf fusion protein polynucleotide

<400>  131
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gaggtgcagc tggtggagag cggcggaggc ctcgtgcagc ccggcggatc tctgcggctg      120

agctgcgccg ctagcggctt caacatcaag gacacctaca tccactgggt gcgccaggcc      180

cccggcaagg gcctggagtg ggtggcccgg atctacccca ccaacggcta cacccgctac      240

gccgacagcg tgaagggccg gttcaccatc agcgccgaca cctccaagaa caccgcctac      300

ctgcagatga acagcctgcg cgccgaggac accgccgtgt actactgcag ccggtggggc      360

ggcgacggat tctacgccat ggactactgg ggacagggca ccctggtgac cgtgagcagc      420

gcctctacca agggccccag cgtgttccct ctggccccca gcagcaagag caccagcggc      480

ggaaccgccg ccctgggctg cctggtgaag gactacttcc ccgagcccgt gaccgtgtcc      540

tggaacagcg gcgctctgac cagcggagtg cacaccttcc ctgccgtgct gcagagcagc      600

ggcctgtact ccctgagcag cgtggtgacc gtgcccagca gcagcctggg cacccagacc      660

tacatctgca acgtgaacca caagccctcc aacaccaagg tggacaagaa ggtggagcct      720

aagagctgcg acaagaccca cacctgccct ccctgccccg cccccgagct gctgggcgga      780

cccagcgtgt tcctgttccc tcccaagccc aaggacaccc tgatgatcag ccgcaccccc      840

gaggtgacct gcgtggtggt ggacgtgagc cacgaggacc ccgaggtgaa gttcaactgg      900

tacgtggacg gcgtggaggt gcacaacgcc aagaccaagc ctcgggagga gcagtacaac      960

tccacctacc gcgtggtgag cgtgctgacc gtgctgcacc aggactggct gaacggcaag     1020

gagtacaagt gcaaggtgag caacaaggcc ctgcccgctc ccatcgagaa gaccatcagc     1080

aaggccaagg gccagccccg ggagcctcag gtgtacaccc tgccccccag ccgcgacgag     1140

ctgaccaaga accaggtgag cctgacctgc ctggtgaagg gcttctaccc ctccgacatc     1200

gccgtggagt gggagagcaa cggccagcct gagaacaact acaagaccac ccctcccgtg     1260

ctggacagcg acggcagctt cttcctgtac agcaagctga ccgtggacaa gtcccggtgg     1320

cagcagggca acgtgttcag ctgcagcgtg atgcacgagg ccctgcacaa ccactacacc     1380

cagaagagcc tgagcctgag ccccggaaag ggaggtggcg gttctggtgg cggaggatct     1440

ggcggaggcg gatccggcat ggaagtgcgt tggtgcgcca cctctgaccc cgagcagcac     1500

aagtgcggca acatgtccga ggccttcaga gaggccggca tccagccttc tctgctgtgt     1560

gtgcggggca cctctgccga ccattgcgtg cagctgatcg ccgcccagga agccgacgct     1620

atcacactgg atggcggcgc tatctacgag gctggcaaag agcacggcct gaagcccgtc     1680

gtgggcgagg tgtacgatca ggaagtgggc acctcctact acgccgtggc tgtcgtgcgg     1740

agatcctccc acgtgaccat cgacaccctg aagggcgtga agtcctgcca caccggcatc     1800

aacagaaccg tgggctggaa cgtgcccgtg ggctacctgg tggaatccgg cagactgtcc     1860

gtgatgggct gcgacgtgct gaaggccgtg tccgattact tcggcggctc ttgtgtgcct     1920

ggcgctggcg agacatccta ctccgagtcc ctgtgcagac tgtgcagggg cgactcttct     1980

ggcgagggcg tgtgcgacaa gtcccctctg gaacggtact acgactactc cggcgccttc     2040

agatgcctgg ctgaaggtgc tggcgacgtg gccttcgtga agcactccac cgtgctggaa     2100

aacaccgacg gcaagaccct gccttcttgg ggccaggcac tgctgtccca ggacttcgag     2160

ctgctgtgcc gggatggctc cagagccgat gtgacagagt ggcggcagtg ccacctggcc     2220

agagtgcctg ctcatgctgt ggtcgtgcgc gccgatacag atggcggcct gatcttccgg     2280

ctgctgaacg agggccagcg gctgttctct cacgagggct ccagcttcca gatgttctcc     2340

agcgaggcct acggccagaa ggacctgctg ttcaaggact ccacctccga gctggtgcct     2400

atcgccaccc agacctatga ggcttggctg ggccacgagt acctgcacgc tatgaaggga     2460

ctgctgtgcg accccaaccg gctgcctcct tatctgaggt ggtgcgtgct gtccaccccc     2520

gagatccaga aatgcggcga tatggccgtg gcctttcggc ggcagagact gaagcctgag     2580

atccagtgcg tgtccgccaa gagccctcag cactgcatgg aacggatcca ggccgaacag     2640

gtggacgccg tgacactgtc cggcgaggat atctacaccg ccggaaagac ctacggcctg     2700

gtgccagctg ctggcgagca ttacgcccct gaggactcct ccaacagcta ctacgtggtg     2760

gcagtcgtgc gccgggactc ctctcacgcc tttaccctgg atgagctgcg gggcaagaga     2820

agctgtcacg ccggctttgg aagccctgcc ggatgggatg tgcctgtggg cgctctgatc     2880

cagcggggct tcatcagacc caaggactgt gatgtgctga ccgccgtgtc tgagttcttc     2940

aacgcctcct gtgtgcccgt gaacaacccc aagaactacc cctccagcct gtgcgccctg     3000

tgtgtgggag atgagcaggg ccggaacaaa tgcgtgggca actcccagga aagatattac     3060

ggctacagag gcgccttccg gtgtctggtg gaaaacgccg gggatgtggc ttttgtgcgg     3120

cacaccaccg tgttcgacaa caccaatggc cacaactccg agccttgggc cgctgagctg     3180

agatccgagg attacgaact gctgtgtccc aacggcgcca gggctgaggt gtcccagttt     3240

gccgcctgta acctggccca gatccctccc cacgctgtga tggtgcgacc cgacaccaac     3300

atcttcaccg tgtacggcct gctggacaag gcccaggatc tgttcggcga cgaccacaac     3360

aagaacgggt tcaagatgtt cgactccagc aactaccacg gacaggatct gctgtttaaa     3420

gatgccaccg tgcgggccgt gccagtgggc gaaaagacca cctacagagg atggctggga     3480

ctggactacg tggccgccct ggaaggcatg tcctcccagc agtgttccgg ctag           3534


<210>  132
<211>  705
<212>  DNA
<213>  Homo sapiens

<400>  132
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag cccttccagc ctgagcgcca gcgtgggcga ccgggtgacc      120

atcacctgcc gcgctagcca ggacgtgaac accgccgtgg cctggtacca gcagaagccc      180

ggaaaggccc ccaagctgct gatctactct gctagcttcc tgtacagcgg cgtgcccagc      240

cggttcagcg gatctcgcag cggcaccgac ttcaccctga ccatcagcag cctgcagcct      300

gaggacttcg ccacctacta ctgccagcag cactacacca cgcctcccac cttcggacag      360

ggcaccaagg tggagatcaa gcggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  133
<211>  1497
<212>  DNA
<213>  Homo sapiens

<400>  133
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gaggtgcagc tggtggagag cggcggaggc ctcgtgcagc ccggcggatc tctgcggctg      120

agctgcgccg ctagcggctt caacatcaag gacacctaca tccactgggt gcgccaggcc      180

cccggcaagg gcctggagtg ggtggcccgg atctacccca ccaacggcta cacccgctac      240

gccgacagcg tgaagggccg gttcaccatc agcgccgaca cctccaagaa caccgcctac      300

ctgcagatga acagcctgcg cgccgaggac accgccgtgt actactgcag ccggtggggc      360

ggcgacggat tctacgccat ggactactgg ggacagggca ccctggtgac cgtgagcagc      420

gcctctacca agggccccag cgtgttccct ctggccccca gcagcaagag caccagcggc      480

ggaaccgccg ccctgggctg cctggtgaag gactacttcc ccgagcccgt gaccgtgtcc      540

tggaacagcg gcgctctgac cagcggagtg cacaccttcc ctgccgtgct gcagagcagc      600

ggcctgtact ccctgagcag cgtggtgacc gtgcccagca gcagcctggg cacccagacc      660

tacatctgca acgtgaacca caagccctcc aacaccaagg tggacaagaa ggtggagcct      720

aagagctgcg acaagaccca cacctgccct ccctgccccg cccccgagct gctgggcgga      780

cccagcgtgt tcctgttccc tcccaagccc aaggacaccc tgatgatcag ccgcaccccc      840

gaggtgacct gcgtggtggt ggacgtgagc cacgaggacc ccgaggtgaa gttcaactgg      900

tacgtggacg gcgtggaggt gcacaacgcc aagaccaagc ctcgggagga gcagtacaac      960

tccacctacc gcgtggtgag cgtgctgacc gtgctgcacc aggactggct gaacggcaag     1020

gagtacaagt gcaaggtgag caacaaggcc ctgcccgctc ccatcgagaa gaccatcagc     1080

aaggccaagg gccagccccg ggagcctcag gtgtacaccc tgccccccag ccgcgacgag     1140

ctgaccaaga accaggtgag cctgacctgc ctggtgaagg gcttctaccc ctccgacatc     1200

gccgtggagt gggagagcaa cggccagcct gagaacaact acaagaccac ccctcccgtg     1260

ctggacagcg acggcagctt cttcctgtac agcaagctga ccgtggacaa gtcccggtgg     1320

cagcagggca acgtgttcag ctgcagcgtg atgcacgagg ccctgcacaa ccactacacc     1380

cagaagagcc tgagcctgag ccccggaaag gaggccgctg ctaaagaggc tgccgccaaa     1440

gaagccgccg ctaaggactc ctctcacgcc ttcaccctgg acgagctgcg gtactaa        1497


<210>  134
<211>  789
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC-MTfp/Fc-MTfp fusion protein polynucleotid

<400>  134
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag cccttccagc ctgagcgcca gcgtgggcga ccgggtgacc      120

atcacctgcc gcgctagcca ggacgtgaac accgccgtgg cctggtacca gcagaagccc      180

ggaaaggccc ccaagctgct gatctactct gctagcttcc tgtacagcgg cgtgcccagc      240

cggttcagcg gatctcgcag cggcaccgac ttcaccctga ccatcagcag cctgcagcct      300

gaggacttcg ccacctacta ctgccagcag cactacacca cgcctcccac cttcggacag      360

ggcaccaagg tagagatcaa gcggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gcgaggccgc tgctaaagag      720

gctgccgcca aagaagccgc cgctaaggac tcctctcacg ccttcaccct ggacgagctg      780

cggtactaa                                                              789


<210>  135
<211>  1497
<212>  DNA
<213>  Homo sapiens

<400>  135
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gaggtgcagc tggtggagag cggcggaggc ctcgtgcagc ccggcggatc tctgcggctg      120

agctgcgccg ctagcggctt caacatcaag gacacctaca tccactgggt gcgccaggcc      180

cccggcaagg gcctggagtg ggtggcccgg atctacccca ccaacggcta cacccgctac      240

gccgacagcg tgaagggccg gttcaccatc agcgccgaca cctccaagaa caccgcctac      300

ctgcagatga acagcctgcg cgccgaggac accgccgtgt actactgcag ccggtggggc      360

ggcgacggat tctacgccat ggactactgg ggacagggca ccctggtgac cgtgagcagc      420

gcctctacca agggccccag cgtgttccct ctggccccca gcagcaagag caccagcggc      480

ggaaccgccg ccctgggctg cctggtgaag gactacttcc ccgagcccgt gaccgtgtcc      540

tggaacagcg gcgctctgac cagcggagtg cacaccttcc ctgccgtgct gcagagcagc      600

ggcctgtact ccctgagcag cgtggtgacc gtgcccagca gcagcctggg cacccagacc      660

tacatctgca acgtgaacca caagccctcc aacaccaagg tggacaagaa ggtggagcct      720

aagagctgcg acaagaccca cacctgccct ccctgccccg cccccgagct gctgggcgga      780

cccagcgtgt tcctgttccc tcccaagccc aaggacaccc tgatgatcag ccgcaccccc      840

gaggtgacct gcgtggtggt ggacgtgagc cacgaggacc ccgaggtgaa gttcaactgg      900

tacgtggacg gcgtggaggt gcacaacgcc aagaccaagc ctcgggagga gcagtacaac      960

tccacctacc gcgtggtgag cgtgctgacc gtgctgcacc aggactggct gaacggcaag     1020

gagtacaagt gcaaggtgag caacaaggcc ctgcccgctc ccatcgagaa gaccatcagc     1080

aaggccaagg gccagccccg ggagcctcag gtgtacaccc tgccccccag ccgcgacgag     1140

ctgaccaaga accaggtgag cctgacctgc ctggtgaagg gcttctaccc ctccgacatc     1200

gccgtggagt gggagagcaa cggccagcct gagaacaact acaagaccac ccctcccgtg     1260

ctggacagcg acggcagctt cttcctgtac agcaagctga ccgtggacaa gtcccggtgg     1320

cagcagggca acgtgttcag ctgcagcgtg atgcacgagg ccctgcacaa ccactacacc     1380

cagaagagcc tgagcctgag ccccggaaag gaggccgctg ctaaagaggc tgccgccaaa     1440

gaagccgccg ctaaggactc ctctcacgcc ttcaccctgg acgagctgcg gtactaa        1497


<210>  136
<211>  705
<212>  DNA
<213>  Homo sapiens

<400>  136
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag cccttccagc ctgagcgcca gcgtgggcga ccgggtgacc      120

atcacctgcc gcgctagcca ggacgtgaac accgccgtgg cctggtacca gcagaagccc      180

ggaaaggccc ccaagctgct gatctactct gctagcttcc tgtacagcgg cgtgcccagc      240

cggttcagcg gatctcgcag cggcaccgac ttcaccctga ccatcagcag cctgcagcct      300

gaggacttcg ccacctacta ctgccagcag cactacacca cgcctcccac cttcggacag      360

ggcaccaagg tggagatcaa gcggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gctaa                      705


<210>  137
<211>  1413
<212>  DNA
<213>  Homo sapiens

<400>  137
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gaggtgcagc tggtggagag cggcggaggc ctcgtgcagc ccggcggatc tctgcggctg      120

agctgcgccg ctagcggctt caacatcaag gacacctaca tccactgggt gcgccaggcc      180

cccggcaagg gcctggagtg ggtggcccgg atctacccca ccaacggcta cacccgctac      240

gccgacagcg tgaagggccg gttcaccatc agcgccgaca cctccaagaa caccgcctac      300

ctgcagatga acagcctgcg cgccgaggac accgccgtgt actactgcag ccggtggggc      360

ggcgacggat tctacgccat ggactactgg ggacagggca ccctggtgac cgtgagcagc      420

gcctctacca agggccccag cgtgttccct ctggccccca gcagcaagag caccagcggc      480

ggaaccgccg ccctgggctg cctggtgaag gactacttcc ccgagcccgt gaccgtgtcc      540

tggaacagcg gcgctctgac cagcggagtg cacaccttcc ctgccgtgct gcagagcagc      600

ggcctgtact ccctgagcag cgtggtgacc gtgcccagca gcagcctggg cacccagacc      660

tacatctgca acgtgaacca caagccctcc aacaccaagg tggacaagaa ggtggagcct      720

aagagctgcg acaagaccca cacctgccct ccctgccccg cccccgagct gctgggcgga      780

cccagcgtgt tcctgttccc tcccaagccc aaggacaccc tgatgatcag ccgcaccccc      840

gaggtgacct gcgtggtggt ggacgtgagc cacgaggacc ccgaggtgaa gttcaactgg      900

tacgtggacg gcgtggaggt gcacaacgcc aagaccaagc ctcgggagga gcagtacaac      960

tccacctacc gcgtggtgag cgtgctgacc gtgctgcacc aggactggct gaacggcaag     1020

gagtacaagt gcaaggtgag caacaaggcc ctgcccgctc ccatcgagaa gaccatcagc     1080

aaggccaagg gccagccccg ggagcctcag gtgtacaccc tgccccccag ccgcgacgag     1140

ctgaccaaga accaggtgag cctgacctgc ctggtgaagg gcttctaccc ctccgacatc     1200

gccgtggagt gggagagcaa cggccagcct gagaacaact acaagaccac ccctcccgtg     1260

ctggacagcg acggcagctt cttcctgtac agcaagctga ccgtggacaa gtcccggtgg     1320

cagcagggca acgtgttcag ctgcagcgtg atgcacgagg ccctgcacaa ccactacacc     1380

cagaagagcc tgagcctgag ccccggaaag taa                                  1413


<210>  138
<211>  789
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC-MTfp/Fc fusion protein polynucleotide

<400>  138
atggagaccg acaccctgct gctctgggtg ctgctgctct gggtgcccgg ctccaccgga       60

gacatccaga tgacccagag cccttccagc ctgagcgcca gcgtgggcga ccgggtgacc      120

atcacctgcc gcgctagcca ggacgtgaac accgccgtgg cctggtacca gcagaagccc      180

ggaaaggccc ccaagctgct gatctactct gctagcttcc tgtacagcgg cgtgcccagc      240

cggttcagcg gatctcgcag cggcaccgac ttcaccctga ccatcagcag cctgcagcct      300

gaggacttcg ccacctacta ctgccagcag cactacacca cgcctcccac cttcggacag      360

ggcaccaagg tagagatcaa gcggaccgtg gccgccccca gcgtgttcat cttccctccc      420

agcgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      480

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ccgagcagga ctccaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccaggga      660

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gcgaggccgc tgctaaagag      720

gctgccgcca aagaagccgc cgctaaggac tcctctcacg ccttcaccct ggacgagctg      780

cggtactaa                                                              789


