                         SEQUENCE LISTING

<110>  Biogen Idec MA Inc.
 
<120>  METHODS OF INCREASING PROTEIN PRODUCTION IN MAMMALIAN CELLS

<130>  B1152.70037WO00

<140>  TBD
<141>  2015-01-30

<150>  US 61/934,661
<151>  2014-01-31

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  2465
<212>  DNA
<213>  Homo sapiens

<400>  1
gttgaagctc ggcgctcggg ttacccctgc agcgacgccc cctggtccca cagataccac       60

tgctgctccc gccctttcgc tcctcggccg cgcaatgggc acccgcgacg acgagtacga      120

ctacctcttt aaagttgtcc ttattggaga ttctggtgtt ggaaagagta atctcctgtc      180

tcgatttact cgaaatgagt ttaatctgga aagcaagagc accattggag tagagtttgc      240

aacaagaagc atccaggttg atggaaaaac aataaaggca cagatatggg acacagcagg      300

gcaagagcga tatcgagcta taacatcagc atattatcgt ggagctgtag gtgccttatt      360

ggtttatgac attgctaaac atctcacata tgaaaatgta gagcgatggc tgaaagaact      420

gagagatcat gctgatagta acattgttat catgcttgtg ggcaataaga gtgatctacg      480

tcatctcagg gcagttccta cagatgaagc aagagctttt gcagaaaaga atggtttgtc      540

attcattgaa acttcggccc tagactctac aaatgtagaa gctgcttttc agacaatttt      600

aacagagatt taccgcattg tttctcagaa gcaaatgtca gacagacgcg aaaatgacat      660

gtctccaagc aacaatgtgg ttcctattca tgttccacca accactgaaa acaagccaaa      720

ggtgcagtgc tgtcagaaca tctaaggcat ttctcttctc ccctagaagg ctgtgtatag      780

tccatttccc aggtctgaga tttaaatata tttgtaattc ttgtgtcact tttgtgtttt      840

attacttcat acttatgaat ttttccatgt cctaagtctt ttgattttag ctttataaaa      900

tcatccactt gtcccgaatg actgcagctt tttttcatgc tatggcttca ctagccttag      960

tttaataaac tgaatgtttg gattcctcag ttattgttta cttttcatca tggaagcctg     1020

tcactgtatg taggacataa tagaacttga tcacttgaag ctcagaccta ttggtcttga     1080

tcaaatcaaa ctaagaagac cttagaaata agctaccatt ttgccacaga gcagcttata     1140

ggtaatacac tcttctctca gtgcagtgta catttccaca aatctaagaa ttgccctata     1200

aacatagcag gattttgaga gcttgaaaat tttccattat tctggacatg aatttctaaa     1260

atgccttaat aggtttatgt agttgagtaa attttgtttt ttaatttttg taagcatcaa     1320

agttgattag agaggggggc actttttctg gagaattctc ttagtaaaca caaaagattg     1380

ttacggtttc attagtagta tggttgtggg gccataagtt aaacagtgct gcctggtagg     1440

ctgggaactg aagagacttg tggtattcca tctcgggtgc ctctgttggc aatgatcagg     1500

cagcccaaaa gatttaaatg atctataata atttccaagc ggtagattat gtggcatttt     1560

attgctcagg caataattgg tttaatgctg gtagtgtcaa attttgtctt agaaccttcc     1620

agtaagtgaa atacaaccta gttttatcac catatccacc agcaggcatg gataattatt     1680

ttaacaatgc taatatttga gttttgcagt atattataga atatagtcca gttaaatctt     1740

tggtttcagt atgtctgaag agtacagtga gaggttaatt tctgctcaag tggtaccact     1800

taaaggcatg tattctttta gtatgtaaaa tgaaatagta ccttgagttt aaatagaatg     1860

catttaggca ttgtagagat ctgaaatagt tttcttccac tacattgttg aaatcaatga     1920

agcaattagt ttctcattca gaaatgtgca cactaatatt tagttttgct ttctcgtgga     1980

taatattaag cacttactct gcagtttcct ggaagttgtg tcaactgcag tgatactatt     2040

caggatggtg ggaaatcccc aaaaatatgt atgtgtgggc ttgcttagat tactatattt     2100

catagttaat cttttgtctc ttgcggtgct catgatgtgt ggggcacacg gaaggcattg     2160

ctgtagtcag tcattttggt tttcttctat agccatttta ttattttagt gtattagtta     2220

tgaagataat attatctatt tgtaaattgc tactttgtat tttatgcatg ctctgtaatt     2280

tgattttttt ttagttattg atttggatta tattcacatt ctaataaaca gttatagggg     2340

gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2400

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2460

aaaaa                                                                 2465


<210>  2
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Thr Arg Asp Asp Glu Tyr Asp Tyr Leu Phe Lys Val Val Leu 
1               5                   10                  15      


Ile Gly Asp Ser Gly Val Gly Lys Ser Asn Leu Leu Ser Arg Phe Thr 
            20                  25                  30          


Arg Asn Glu Phe Asn Leu Glu Ser Lys Ser Thr Ile Gly Val Glu Phe 
        35                  40                  45              


Ala Thr Arg Ser Ile Gln Val Asp Gly Lys Thr Ile Lys Ala Gln Ile 
    50                  55                  60                  


Trp Asp Thr Ala Gly Gln Glu Arg Tyr Arg Ala Ile Thr Ser Ala Tyr 
65                  70                  75                  80  


Tyr Arg Gly Ala Val Gly Ala Leu Leu Val Tyr Asp Ile Ala Lys His 
                85                  90                  95      


Leu Thr Tyr Glu Asn Val Glu Arg Trp Leu Lys Glu Leu Arg Asp His 
            100                 105                 110         


Ala Asp Ser Asn Ile Val Ile Met Leu Val Gly Asn Lys Ser Asp Leu 
        115                 120                 125             


Arg His Leu Arg Ala Val Pro Thr Asp Glu Ala Arg Ala Phe Ala Glu 
    130                 135                 140                 


Lys Asn Gly Leu Ser Phe Ile Glu Thr Ser Ala Leu Asp Ser Thr Asn 
145                 150                 155                 160 


Val Glu Ala Ala Phe Gln Thr Ile Leu Thr Glu Ile Tyr Arg Ile Val 
                165                 170                 175     


Ser Gln Lys Gln Met Ser Asp Arg Arg Glu Asn Asp Met Ser Pro Ser 
            180                 185                 190         


Asn Asn Val Val Pro Ile His Val Pro Pro Thr Thr Glu Asn Lys Pro 
        195                 200                 205             


Lys Val Gln Cys Cys Gln Asn Ile 
    210                 215     


<210>  3
<211>  696
<212>  DNA
<213>  Homo sapiens

<400>  3
caatggggac ccgggacgac gagtacgact acctattcaa agtggtgctc atcggggact       60

caggcgtggg caagagcaac ctgctgtcgc gcttcacccg caacgagttc aacctggaga      120

gcaagagcac catcggcgtg gagttcgcca cccgcagcat ccaggtggac ggcaagacca      180

tcaaggcgca gatctgggac accgctggcc aggagcgcta ccgcgccatc acctccgcgt      240

actaccgtgg tgcagtgggc gccctgctgg tgtacgacat cgccaagcac ctgacctatg      300

agaacgtgga gcgctggctg aaggagctgc gggaccacgc agacagcaac atcgtcatca      360

tgctggtggg caacaagagt gacctgcgcc acctgcgggc tgtgcccact gacgaggccc      420

gcgccttcgc agaaaagaac aacttgtcct tcatcgagac ctcagccttg gattccacta      480

acgtagagga agcattcaag aacatcctca cagagatcta ccgcatcgtg tcacagaaac      540

agatcgcaga ccgtgctgcc cacgacgagt ccccggggaa caacgtggtg gacatcagcg      600

tgccgcccac cacggacgga cagaagccca acaagctgca gtgctgccag aacctgtgac      660

ccctgcgcct ccacccagcg tgcgtgcacg tcctcc                                696


<210>  4
<211>  218
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gly Thr Arg Asp Asp Glu Tyr Asp Tyr Leu Phe Lys Val Val Leu 
1               5                   10                  15      


Ile Gly Asp Ser Gly Val Gly Lys Ser Asn Leu Leu Ser Arg Phe Thr 
            20                  25                  30          


Arg Asn Glu Phe Asn Leu Glu Ser Lys Ser Thr Ile Gly Val Glu Phe 
        35                  40                  45              


Ala Thr Arg Ser Ile Gln Val Asp Gly Lys Thr Ile Lys Ala Gln Ile 
    50                  55                  60                  


Trp Asp Thr Ala Gly Gln Glu Arg Tyr Arg Ala Ile Thr Ser Ala Tyr 
65                  70                  75                  80  


Tyr Arg Gly Ala Val Gly Ala Leu Leu Val Tyr Asp Ile Ala Lys His 
                85                  90                  95      


Leu Thr Tyr Glu Asn Val Glu Arg Trp Leu Lys Glu Leu Arg Asp His 
            100                 105                 110         


Ala Asp Ser Asn Ile Val Ile Met Leu Val Gly Asn Lys Ser Asp Leu 
        115                 120                 125             


Arg His Leu Arg Ala Val Pro Thr Asp Glu Ala Arg Ala Phe Ala Glu 
    130                 135                 140                 


Lys Asn Asn Leu Ser Phe Ile Glu Thr Ser Ala Leu Asp Ser Thr Asn 
145                 150                 155                 160 


Val Glu Glu Ala Phe Lys Asn Ile Leu Thr Glu Ile Tyr Arg Ile Val 
                165                 170                 175     


Ser Gln Lys Gln Ile Ala Asp Arg Ala Ala His Asp Glu Ser Pro Gly 
            180                 185                 190         


Asn Asn Val Val Asp Ile Ser Val Pro Pro Thr Thr Asp Gly Gln Lys 
        195                 200                 205             


Pro Asn Lys Leu Gln Cys Cys Gln Asn Leu 
    210                 215             


<210>  5
<211>  903
<212>  DNA
<213>  Mus musculus

<400>  5
ggctcgtcac cgggtccggc agctgaagct cctcgctcgc tcgggttacc cctgcagcga       60

cgccccctgg tcccgccgcc gttgccaccg ccgctcccgc ccctcagctc ctcggccgcg      120

ccatgggcac ccgcgacgac gagtacgact acctctttaa agttgtcctt attggagatt      180

ctggtgttgg aaagagtaac ctcctgtctc gatttactcg aaatgagttt aatctggaaa      240

gcaagagtac cattggagta gagtttgcaa caagaagcat ccaggttgat gggaaaacaa      300

taaaggcaca gatatgggac acagcagggc aggagcggta cagggctata acgtctgcat      360

actatcgtgg agcagtaggt gccttattgg tttatgacat tgctaagcat ctcacatatg      420

aaaatgtaga gcgatggctg aaagaactga gagatcatgc tgatagtaac attgttatca      480

tgcttgtggg caataagagt gatttacgtc atctcagggc agttcctaca gatgaagcaa      540

gagcttttgc agagaagaat ggtttgtcat tcattgagac atctgctcta gattctacaa      600

atgttgaagc tgcttttcag acaattctaa cagagatata ccgcattgtt tctcagaagc      660

aaatgtcaga cagacgtgaa aatgacatgt ctccaagcaa caatgtggtt cctattcatg      720

ttccgcccac cactgagaac aagccaaagg tgcagtgctg tcagaacatc taaggcgtct      780

cttcccctag aaggctgtgt atagtccatt tcccaggtct gagatttaaa tatatttgta      840

attcttgtgg tcaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      900

aaa                                                                    903


<210>  6
<211>  216
<212>  PRT
<213>  Mus musculus

<400>  6

Met Gly Thr Arg Asp Asp Glu Tyr Asp Tyr Leu Phe Lys Val Val Leu 
1               5                   10                  15      


Ile Gly Asp Ser Gly Val Gly Lys Ser Asn Leu Leu Ser Arg Phe Thr 
            20                  25                  30          


Arg Asn Glu Phe Asn Leu Glu Ser Lys Ser Thr Ile Gly Val Glu Phe 
        35                  40                  45              


Ala Thr Arg Ser Ile Gln Val Asp Gly Lys Thr Ile Lys Ala Gln Ile 
    50                  55                  60                  


Trp Asp Thr Ala Gly Gln Glu Arg Tyr Arg Ala Ile Thr Ser Ala Tyr 
65                  70                  75                  80  


Tyr Arg Gly Ala Val Gly Ala Leu Leu Val Tyr Asp Ile Ala Lys His 
                85                  90                  95      


Leu Thr Tyr Glu Asn Val Glu Arg Trp Leu Lys Glu Leu Arg Asp His 
            100                 105                 110         


Ala Asp Ser Asn Ile Val Ile Met Leu Val Gly Asn Lys Ser Asp Leu 
        115                 120                 125             


Arg His Leu Arg Ala Val Pro Thr Asp Glu Ala Arg Ala Phe Ala Glu 
    130                 135                 140                 


Lys Asn Gly Leu Ser Phe Ile Glu Thr Ser Ala Leu Asp Ser Thr Asn 
145                 150                 155                 160 


Val Glu Ala Ala Phe Gln Thr Ile Leu Thr Glu Ile Tyr Arg Ile Val 
                165                 170                 175     


Ser Gln Lys Gln Met Ser Asp Arg Arg Glu Asn Asp Met Ser Pro Ser 
            180                 185                 190         


Asn Asn Val Val Pro Ile His Val Pro Pro Thr Thr Glu Asn Lys Pro 
        195                 200                 205             


Lys Val Gln Cys Cys Gln Asn Ile 
    210                 215     


<210>  7
<211>  657
<212>  DNA
<213>  Mus musculus

<400>  7
atggggaccc gggacgacga gtacgattac ctattcaaag tggtgcttat tggggactca       60

ggtgtaggta agagcaacct gctgtcacgc ttcaccagaa acgaattcaa cctagagagc      120

aagagtacca tcggagtgga gttcgccact cgcagcattc aggtggacgg caagaccatc      180

aaggctcaga tctgggacac tgctggccag gagcgctacc gtgccattac ctctgcgtac      240

taccgtggtg cagtgggtgc actgctggta tatgacattg ccaagcactt gacatatgag      300

aacgtggagc gctggctgaa ggagctgcgg gatcatgcag atagcaacat tgtcatcatg      360

ctggtgggca acaagagtga cctgcgccac cttcgggctg tgcccactga tgaggcccgt      420

gcctttgcag aaaagaacaa cttgtccttc attgagacct cagccttgga ttccaccaat      480

gtagaggaag cattcaagaa catcctcaca gaaatctacc gtattgtgtc acagaagcaa      540

atcgctgacc gtgcagccca cgatgagtcc cctggcaaca acgtggtgga catcagtgtg      600

ccacccacca ccgatggaca gagacccaac aagctgcagt gctgccagag cctgtga         657


<210>  8
<211>  218
<212>  PRT
<213>  Mus musculus

<400>  8

Met Gly Thr Arg Asp Asp Glu Tyr Asp Tyr Leu Phe Lys Val Val Leu 
1               5                   10                  15      


Ile Gly Asp Ser Gly Val Gly Lys Ser Asn Leu Leu Ser Arg Phe Thr 
            20                  25                  30          


Arg Asn Glu Phe Asn Leu Glu Ser Lys Ser Thr Ile Gly Val Glu Phe 
        35                  40                  45              


Ala Thr Arg Ser Ile Gln Val Asp Gly Lys Thr Ile Lys Ala Gln Ile 
    50                  55                  60                  


Trp Asp Thr Ala Gly Gln Glu Arg Tyr Arg Ala Ile Thr Ser Ala Tyr 
65                  70                  75                  80  


Tyr Arg Gly Ala Val Gly Ala Leu Leu Val Tyr Asp Ile Ala Lys His 
                85                  90                  95      


Leu Thr Tyr Glu Asn Val Glu Arg Trp Leu Lys Glu Leu Arg Asp His 
            100                 105                 110         


Ala Asp Ser Asn Ile Val Ile Met Leu Val Gly Asn Lys Ser Asp Leu 
        115                 120                 125             


Arg His Leu Arg Ala Val Pro Thr Asp Glu Ala Arg Ala Phe Ala Glu 
    130                 135                 140                 


Lys Asn Asn Leu Ser Phe Ile Glu Thr Ser Ala Leu Asp Ser Thr Asn 
145                 150                 155                 160 


Val Glu Glu Ala Phe Lys Asn Ile Leu Thr Glu Ile Tyr Arg Ile Val 
                165                 170                 175     


Ser Gln Lys Gln Ile Ala Asp Arg Ala Ala His Asp Glu Ser Pro Gly 
            180                 185                 190         


Asn Asn Val Val Asp Ile Ser Val Pro Pro Thr Thr Asp Gly Gln Arg 
        195                 200                 205             


Pro Asn Lys Leu Gln Cys Cys Gln Ser Leu 
    210                 215             


<210>  9
<211>  1401
<212>  DNA
<213>  Homo sapiens

<400>  9
atggatcccg ggcagcagcc gccgcctcaa ccggcccccc agggccaagg gcagccgcct       60

tcgcagcccc cgcaggggca gggcccgccg tccggacccg ggcaaccggc acccgcggcg      120

acccaggcgg cgccgcaggc accccccgcc gggcatcaga tcgtgcacgt ccgcggggac      180

tcggagaccg acctggaggc gctcttcaac gccgtcatga accccaagac ggccaacgtg      240

ccccagaccg tgcccatgag gctccggaag ctgcccgact ccttcttcaa gccgccggag      300

cccaaatccc actcccgaca ggccagtact gatgcaggca ctgcaggagc cctgactcca      360

cagcatgttc gagctcattc ctctccagct tctctgcagt tgggagctgt ttctcctggg      420

acactgaccc ccactggagt agtctctggc ccagcagcta cacccacagc tcagcatctt      480

cgacagtctt cttttgagat acctgatgat gtacctctgc cagcaggttg ggagatggca      540

aagacatctt ctggtcagag atacttctta aatcacatcg atcagacaac aacatggcag      600

gaccccagga aggccatgct gtcccagatg aacgtcacag cccccaccag tccaccagtg      660

cagcagaata tgatgaactc ggcttcagcc atgaaccaga gaatcagtca gagtgctcca      720

gtgaaacagc caccacccct ggctccccag agcccacagg gaggcgtcat gggtggcagc      780

aactccaacc agcagcaaca gatgcgactg cagcaactgc agatggagaa ggagaggctg      840

cggctgaaac agcaagaact gcttcggcag gcaatgcgga atatcaatcc cagcacagca      900

aattctccaa aatgtcagga gttagccctg cgtagccagt taccaacact ggagcaggat      960

ggtgggactc aaaatccagt gtcttctccc gggatgtctc aggaattgag aacaatgacg     1020

accaatagct cagatccttt ccttaacagt ggcacctatc actctcgaga tgagagtaca     1080

gacagtggac taagcatgag cagctacagt gtccctcgaa ccccagatga cttcctgaac     1140

agtgtggatg agatggatac aggtgatact atcaaccaaa gcaccctgcc ctcacagcag     1200

aaccgtttcc cagactacct tgaagccatt cctgggacaa atgtggacct tggaacactg     1260

gaaggagatg gaatgaacat agaaggagag gagctgatgc caagtctgca ggaagctttg     1320

agttctgaca tccttaatga catggagtct gttttggctg ccaccaagct agataaagaa     1380

agctttctta catggttata g                                               1401


<210>  10
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Asp Pro Gly Gln Gln Pro Pro Pro Gln Pro Ala Pro Gln Gly Gln 
1               5                   10                  15      


Gly Gln Pro Pro Ser Gln Pro Pro Gln Gly Gln Gly Pro Pro Ser Gly 
            20                  25                  30          


Pro Gly Gln Pro Ala Pro Ala Ala Thr Gln Ala Ala Pro Gln Ala Pro 
        35                  40                  45              


Pro Ala Gly His Gln Ile Val His Val Arg Gly Asp Ser Glu Thr Asp 
    50                  55                  60                  


Leu Glu Ala Leu Phe Asn Ala Val Met Asn Pro Lys Thr Ala Asn Val 
65                  70                  75                  80  


Pro Gln Thr Val Pro Met Arg Leu Arg Lys Leu Pro Asp Ser Phe Phe 
                85                  90                  95      


Lys Pro Pro Glu Pro Lys Ser His Ser Arg Gln Ala Ser Thr Asp Ala 
            100                 105                 110         


Gly Thr Ala Gly Ala Leu Thr Pro Gln His Val Arg Ala His Ser Ser 
        115                 120                 125             


Pro Ala Ser Leu Gln Leu Gly Ala Val Ser Pro Gly Thr Leu Thr Pro 
    130                 135                 140                 


Thr Gly Val Val Ser Gly Pro Ala Ala Thr Pro Thr Ala Gln His Leu 
145                 150                 155                 160 


Arg Gln Ser Ser Phe Glu Ile Pro Asp Asp Val Pro Leu Pro Ala Gly 
                165                 170                 175     


Trp Glu Met Ala Lys Thr Ser Ser Gly Gln Arg Tyr Phe Leu Asn His 
            180                 185                 190         


Ile Asp Gln Thr Thr Thr Trp Gln Asp Pro Arg Lys Ala Met Leu Ser 
        195                 200                 205             


Gln Met Asn Val Thr Ala Pro Thr Ser Pro Pro Val Gln Gln Asn Met 
    210                 215                 220                 


Met Asn Ser Ala Ser Ala Met Asn Gln Arg Ile Ser Gln Ser Ala Pro 
225                 230                 235                 240 


Val Lys Gln Pro Pro Pro Leu Ala Pro Gln Ser Pro Gln Gly Gly Val 
                245                 250                 255     


Met Gly Gly Ser Asn Ser Asn Gln Gln Gln Gln Met Arg Leu Gln Gln 
            260                 265                 270         


Leu Gln Met Glu Lys Glu Arg Leu Arg Leu Lys Gln Gln Glu Leu Leu 
        275                 280                 285             


Arg Gln Ala Met Arg Asn Ile Asn Pro Ser Thr Ala Asn Ser Pro Lys 
    290                 295                 300                 


Cys Gln Glu Leu Ala Leu Arg Ser Gln Leu Pro Thr Leu Glu Gln Asp 
305                 310                 315                 320 


Gly Gly Thr Gln Asn Pro Val Ser Ser Pro Gly Met Ser Gln Glu Leu 
                325                 330                 335     


Arg Thr Met Thr Thr Asn Ser Ser Asp Pro Phe Leu Asn Ser Gly Thr 
            340                 345                 350         


Tyr His Ser Arg Asp Glu Ser Thr Asp Ser Gly Leu Ser Met Ser Ser 
        355                 360                 365             


Tyr Ser Val Pro Arg Thr Pro Asp Asp Phe Leu Asn Ser Val Asp Glu 
    370                 375                 380                 


Met Asp Thr Gly Asp Thr Ile Asn Gln Ser Thr Leu Pro Ser Gln Gln 
385                 390                 395                 400 


Asn Arg Phe Pro Asp Tyr Leu Glu Ala Ile Pro Gly Thr Asn Val Asp 
                405                 410                 415     


Leu Gly Thr Leu Glu Gly Asp Gly Met Asn Ile Glu Gly Glu Glu Leu 
            420                 425                 430         


Met Pro Ser Leu Gln Glu Ala Leu Ser Ser Asp Ile Leu Asn Asp Met 
        435                 440                 445             


Glu Ser Val Leu Ala Ala Thr Lys Leu Asp Lys Glu Ser Phe Leu Thr 
    450                 455                 460                 


Trp Leu 
465     


<210>  11
<211>  1665
<212>  DNA
<213>  Homo sapiens

<400>  11
cgcgcgctca ggctcagctt cgctgcccgc ccaggtagtg cccgctggag ctcgcgcgct       60

catccggcac cactccaggg ctccaggctc ctcgggcttc cggagtcgag acgtggtgga      120

gttggctcgg gctgaacttc tttcgggggg ctgcctgtcc ttctttttgc agaagatgaa      180

tccggcctcg gcgccccctc cgctcccgcc gcctgggcag caagtgatcc acgtcacgca      240

ggacctagac acagacctcg aagccctctt caactctgtc atgaatccga agcctagctc      300

gtggcggaag aagatcctgc cggagtcttt ctttaaggag cctgattcgg gctcgcactc      360

gcgccagtcc agcaccgact cgtcgggcgg ccacccgggg cctcgactgg ctgggggtgc      420

ccagcatgtc cgctcgcact cgtcgcccgc gtccctgcag ctgggcaccg gcgcgggtgc      480

tgcgggtagc cccgcgcagc agcacgcgca cctccgccag cagtcctacg acgtgaccga      540

cgagctgcca ctgcccccgg gctgggagat gaccttcacg gccactggcc agaggtactt      600

cctcaatcac atagaaaaaa tcaccacatg gcaagaccct aggaaggcga tgaatcagcc      660

tctgaatcat atgaacctcc accctgccgt cagttccaca ccagtgcctc agaggtccat      720

ggcagtatcc cagccaaatc tcgtgatgaa tcaccaacac cagcagcaga tggcccccag      780

taccctgagc cagcagaacc accccactca gaacccaccc gcagggctca tgagtatgcc      840

caatgcgctg accactcagc agcagcagca gcagaaactg cggcttcaga gaatccagat      900

ggagagagaa aggattcgaa tgcgccaaga ggagctcatg aggcaggaag ctgccctctg      960

tcgacagctc cccatggaag ctgagactct tgccccagtt caggctgctg tcaacccacc     1020

cacgatgacc ccagacatga gatccatcac taataatagc tcagatcctt tcctcaatgg     1080

agggccatat cattcgaggg agcagagcac tgacagtggc ctggggttag ggtgctacag     1140

tgtccccaca actccggagg acttcctcag caatgtggat gagatggata caggagaaaa     1200

cgcaggacaa acacccatga acatcaatcc ccaacagacc cgtttccctg atttccttga     1260

ctgtcttcca ggaacaaacg ttgacttagg aactttggaa tctgaagacc tgatccccct     1320

cttcaatgat gtagagtctg ctctgaacaa aagtgagccc tttctaacct ggctgtaatc     1380

actaccattg taacttggat gtagccatga ccttacattt cctgggcctc ttggaaaaag     1440

tgatggagca gagcaagtct gcaggtgcac cacttcccgc ctccatgact cgtgctccct     1500

cctttttatg ttgccagttt aatcattgcc tggttttgat tgagagtaac ttaagttaaa     1560

cataaataaa tattctattt tcattttcaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1620

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa                     1665


<210>  12
<211>  400
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Asn Pro Ala Ser Ala Pro Pro Pro Leu Pro Pro Pro Gly Gln Gln 
1               5                   10                  15      


Val Ile His Val Thr Gln Asp Leu Asp Thr Asp Leu Glu Ala Leu Phe 
            20                  25                  30          


Asn Ser Val Met Asn Pro Lys Pro Ser Ser Trp Arg Lys Lys Ile Leu 
        35                  40                  45              


Pro Glu Ser Phe Phe Lys Glu Pro Asp Ser Gly Ser His Ser Arg Gln 
    50                  55                  60                  


Ser Ser Thr Asp Ser Ser Gly Gly His Pro Gly Pro Arg Leu Ala Gly 
65                  70                  75                  80  


Gly Ala Gln His Val Arg Ser His Ser Ser Pro Ala Ser Leu Gln Leu 
                85                  90                  95      


Gly Thr Gly Ala Gly Ala Ala Gly Ser Pro Ala Gln Gln His Ala His 
            100                 105                 110         


Leu Arg Gln Gln Ser Tyr Asp Val Thr Asp Glu Leu Pro Leu Pro Pro 
        115                 120                 125             


Gly Trp Glu Met Thr Phe Thr Ala Thr Gly Gln Arg Tyr Phe Leu Asn 
    130                 135                 140                 


His Ile Glu Lys Ile Thr Thr Trp Gln Asp Pro Arg Lys Ala Met Asn 
145                 150                 155                 160 


Gln Pro Leu Asn His Met Asn Leu His Pro Ala Val Ser Ser Thr Pro 
                165                 170                 175     


Val Pro Gln Arg Ser Met Ala Val Ser Gln Pro Asn Leu Val Met Asn 
            180                 185                 190         


His Gln His Gln Gln Gln Met Ala Pro Ser Thr Leu Ser Gln Gln Asn 
        195                 200                 205             


His Pro Thr Gln Asn Pro Pro Ala Gly Leu Met Ser Met Pro Asn Ala 
    210                 215                 220                 


Leu Thr Thr Gln Gln Gln Gln Gln Gln Lys Leu Arg Leu Gln Arg Ile 
225                 230                 235                 240 


Gln Met Glu Arg Glu Arg Ile Arg Met Arg Gln Glu Glu Leu Met Arg 
                245                 250                 255     


Gln Glu Ala Ala Leu Cys Arg Gln Leu Pro Met Glu Ala Glu Thr Leu 
            260                 265                 270         


Ala Pro Val Gln Ala Ala Val Asn Pro Pro Thr Met Thr Pro Asp Met 
        275                 280                 285             


Arg Ser Ile Thr Asn Asn Ser Ser Asp Pro Phe Leu Asn Gly Gly Pro 
    290                 295                 300                 


Tyr His Ser Arg Glu Gln Ser Thr Asp Ser Gly Leu Gly Leu Gly Cys 
305                 310                 315                 320 


Tyr Ser Val Pro Thr Thr Pro Glu Asp Phe Leu Ser Asn Val Asp Glu 
                325                 330                 335     


Met Asp Thr Gly Glu Asn Ala Gly Gln Thr Pro Met Asn Ile Asn Pro 
            340                 345                 350         


Gln Gln Thr Arg Phe Pro Asp Phe Leu Asp Cys Leu Pro Gly Thr Asn 
        355                 360                 365             


Val Asp Leu Gly Thr Leu Glu Ser Glu Asp Leu Ile Pro Leu Phe Asn 
    370                 375                 380                 


Asp Val Glu Ser Ala Leu Asn Lys Ser Glu Pro Phe Leu Thr Trp Leu 
385                 390                 395                 400 


<210>  13
<211>  2569
<212>  DNA
<213>  Mus musculus

<400>  13
cggacgcgtg gggccaaagt ttctgtctca gttgggacgc cgccgcggcc gggggcaaag       60

aaagggagga aggaaggagc tcgcggaggg gaggggagga gaggggaggc ggcctcgggc      120

aaggagtgca gggcgatgcg ggcgcgcgtc gcagcccccc gaacctgagc gcagtgcccc      180

gagcgtcgaa cgaggccgca gccatggagc ccgcgcaaca gccgccgccc cagccggccc      240

cgcaaggccc cgcgccgccg tccgtgtctc cggccgggac ccccgcggcc ccgcccgcac      300

ccccggccgg ccaccaggtc gtgcacgtcc gcggggactc ggagaccgac ttggaggcgc      360

tcttcaatgc cgtcatgaac cccaagacgg ccaacgtgcc tcagaccgtg cccatgcggc      420

ttcgcaagct gcccgactcc ttcttcaagc cgcctgagcc caagtcccac tcgcgacagg      480

ccagtactga tgcaggtact gcgggagctc tgactccaca gcatgttcga gctcactcct      540

ctccagcctc cctgcagctg ggtgccgttt ctcctgggac actcacagcc agtggcgttg      600

tctctggccc tgccgctgcc cctgcagctc agcatctccg gcagtcctcc tttgagatcc      660

ctgatgatgt accactgcca gcaggctggg agatggccaa gacatcttct ggtcaaagat      720

acttcttaaa tcacaacgat cagacaacaa catggcagga cccccggaag gccatgcttt      780

cgcaactgaa cgttcctgcg cctgccagcc cagcggtgcc ccagacgctg atgaattctg      840

cctcaggacc tcttcctgat ggatgggagc aagccatgac tcaggatgga gaagtttact      900

acataaacca taagaacaag accacatcct ggctggaccc aaggctggac cctcgttttg      960

ccatgaacca gaggatcact cagagtgctc cagtgaagca gcccccaccc ttggctcccc     1020

agagcccaca gggaggcgtc ctgggtggag gcagttccaa ccagcagcag caaatacagc     1080

tgcagcagtt acagatggag aaggagagac tgcggttgaa acaacaggaa ttatttcggc     1140

aggcaatacg gaatatcaat cccagcacag caaatgctcc aaaatgtcag gaattagctc     1200

tgcgcagcca gttgcctaca ctggagcagg atggagggac tccgaatgca gtgtcttctc     1260

ctgggatgtc tcaggaattg agaacaatga caaccaatag ttccgatccc tttcttaaca     1320

gtggcaccta tcactctcga gatgagagca cagacagcgg cctcagcatg agcagctaca     1380

gcatccctcg gaccccagac gacttcctca acagtgtgga tgaaatggat acaggagaca     1440

ccatcagcca aagcaccctg ccgtcacagc agagccgctt ccccgactac ctggaagccc     1500

tccctgggac aaatgtggac cttggcacac tggaaggaga tgcaatgaac atagaagggg     1560

aggagctgat gcccagtctg caggaagcgc tgagttccga aatcttggac gtggagtctg     1620

tgttggctgc caccaagcta gataaagaaa gctttctcac gtggttatag agctgcaggg     1680

agccactctg agtctgtgag ggatccacag agcctaagat gtgcacgcct gaaattcaga     1740

taagtcagtg ggggttctct ggctaacaca gaaaacagat gaaccagtgt ccatcgttgt     1800

tccgcttttc tctgcccgtc gctgctctta cgttggttgc tgacctcttc acggccggct     1860

ctaaagaacc cgaaccgcag acagattcct ttgttaactc tgctatgata actacgttct     1920

ctgggattgc tgggggatgg cctgctggat aatggatgtt ctgccttttg tccggtggtc     1980

ctttcaccat cactttaact gaacacacag actgggaact gaatgctcta gaacattgtt     2040

caagaggtgg tttcttcagc tgccttgggt ccaacaagcc agaggcattg cgtctgatct     2100

cgtggaggac ggaggggacc cacgctgaag actggtgaac tttccattct tctgttagcg     2160

atgccgttag gccatagtga cctgggtctt atcttagacg cttatgaggc atgagacagc     2220

ttccatagaa atatattaat tattaccaca tactctagat taggtttgaa tgaatatttt     2280

ctgtgggtgt tttggttggt ttttctctgc cccccccccc ttttttgtgg ttggtcttgg     2340

tggaacgtag gcaaattaat gaattcgttt atagctgtag cttggggtgg gcaataccat     2400

tcttttggtg ggaaatctgt atttcttggt tttttaacat cctatttaaa tcttaaatct     2460

tggttatctc ctctctacat atatacacac tcttattatg tctatggtag tgtgatagca     2520

gaatatatct ttataaacaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa                 2569


<210>  14
<211>  488
<212>  PRT
<213>  Mus musculus

<400>  14

Met Glu Pro Ala Gln Gln Pro Pro Pro Gln Pro Ala Pro Gln Gly Pro 
1               5                   10                  15      


Ala Pro Pro Ser Val Ser Pro Ala Gly Thr Pro Ala Ala Pro Pro Ala 
            20                  25                  30          


Pro Pro Ala Gly His Gln Val Val His Val Arg Gly Asp Ser Glu Thr 
        35                  40                  45              


Asp Leu Glu Ala Leu Phe Asn Ala Val Met Asn Pro Lys Thr Ala Asn 
    50                  55                  60                  


Val Pro Gln Thr Val Pro Met Arg Leu Arg Lys Leu Pro Asp Ser Phe 
65                  70                  75                  80  


Phe Lys Pro Pro Glu Pro Lys Ser His Ser Arg Gln Ala Ser Thr Asp 
                85                  90                  95      


Ala Gly Thr Ala Gly Ala Leu Thr Pro Gln His Val Arg Ala His Ser 
            100                 105                 110         


Ser Pro Ala Ser Leu Gln Leu Gly Ala Val Ser Pro Gly Thr Leu Thr 
        115                 120                 125             


Ala Ser Gly Val Val Ser Gly Pro Ala Ala Ala Pro Ala Ala Gln His 
    130                 135                 140                 


Leu Arg Gln Ser Ser Phe Glu Ile Pro Asp Asp Val Pro Leu Pro Ala 
145                 150                 155                 160 


Gly Trp Glu Met Ala Lys Thr Ser Ser Gly Gln Arg Tyr Phe Leu Asn 
                165                 170                 175     


His Asn Asp Gln Thr Thr Thr Trp Gln Asp Pro Arg Lys Ala Met Leu 
            180                 185                 190         


Ser Gln Leu Asn Val Pro Ala Pro Ala Ser Pro Ala Val Pro Gln Thr 
        195                 200                 205             


Leu Met Asn Ser Ala Ser Gly Pro Leu Pro Asp Gly Trp Glu Gln Ala 
    210                 215                 220                 


Met Thr Gln Asp Gly Glu Val Tyr Tyr Ile Asn His Lys Asn Lys Thr 
225                 230                 235                 240 


Thr Ser Trp Leu Asp Pro Arg Leu Asp Pro Arg Phe Ala Met Asn Gln 
                245                 250                 255     


Arg Ile Thr Gln Ser Ala Pro Val Lys Gln Pro Pro Pro Leu Ala Pro 
            260                 265                 270         


Gln Ser Pro Gln Gly Gly Val Leu Gly Gly Gly Ser Ser Asn Gln Gln 
        275                 280                 285             


Gln Gln Ile Gln Leu Gln Gln Leu Gln Met Glu Lys Glu Arg Leu Arg 
    290                 295                 300                 


Leu Lys Gln Gln Glu Leu Phe Arg Gln Ala Ile Arg Asn Ile Asn Pro 
305                 310                 315                 320 


Ser Thr Ala Asn Ala Pro Lys Cys Gln Glu Leu Ala Leu Arg Ser Gln 
                325                 330                 335     


Leu Pro Thr Leu Glu Gln Asp Gly Gly Thr Pro Asn Ala Val Ser Ser 
            340                 345                 350         


Pro Gly Met Ser Gln Glu Leu Arg Thr Met Thr Thr Asn Ser Ser Asp 
        355                 360                 365             


Pro Phe Leu Asn Ser Gly Thr Tyr His Ser Arg Asp Glu Ser Thr Asp 
    370                 375                 380                 


Ser Gly Leu Ser Met Ser Ser Tyr Ser Ile Pro Arg Thr Pro Asp Asp 
385                 390                 395                 400 


Phe Leu Asn Ser Val Asp Glu Met Asp Thr Gly Asp Thr Ile Ser Gln 
                405                 410                 415     


Ser Thr Leu Pro Ser Gln Gln Ser Arg Phe Pro Asp Tyr Leu Glu Ala 
            420                 425                 430         


Leu Pro Gly Thr Asn Val Asp Leu Gly Thr Leu Glu Gly Asp Ala Met 
        435                 440                 445             


Asn Ile Glu Gly Glu Glu Leu Met Pro Ser Leu Gln Glu Ala Leu Ser 
    450                 455                 460                 


Ser Glu Ile Leu Asp Val Glu Ser Val Leu Ala Ala Thr Lys Leu Asp 
465                 470                 475                 480 


Lys Glu Ser Phe Leu Thr Trp Leu 
                485             


<210>  15
<211>  1610
<212>  DNA
<213>  Mus musculus

<400>  15
gtccgggagc cgcggcggct gcgctcgtct acgtcttctc tgtcgcctcc tcgcgcagtg       60

ggagcgcccg aggccggttc cggggatgta agaggataag ccttcggctg ctgggaatcc      120

gctcgggatc tgcccgggac cgggttccag ctcgtcagtt cgggaggcgc ccaggcttgg      180

cttccccgag tccccagaaa gatgaatccg tcctcggtgc cccatccgct cccgccgcca      240

gggcagcaag tcatccacgt cacgcaggac ctggacaccg acctcgaagc cctcttcaac      300

tctgtcatga accccaagcc cagctcatgg cggaaaaaga tcctcccgga gtccttcttt      360

aaggagcccg attccggctc gcactcgcgc caatccagca cagactcatc aggcggccac      420

ccggggcctc gactagctgg cggcgcgcag cacgtccgct cgcactcgtc gcccgcatcc      480

ctgcagctgg gcaccggtgc gggagccgct ggaggccctg cacagcagca tgcacatctc      540

cgccagcagt cctatgacgt gaccgacgag ctgccgttgc cccccgggtg ggagatgacc      600

ttcacggcca ctggccagag atacttcctt aatcacatag agaaaatcac cacatggcaa      660

gaccccagga aggtgatgaa tcagcctctg aatcatgtga acctccaccc gtccatcact      720

tccacctcgg tgccacagag gtccatggca gtgtcccagc cgaatctcgc aatgaatcac      780

caacaccagc aagtcgtggc cactagcctg agtccacaga accacccgac tcagaaccaa      840

cccacagggc tcatgagtgt gcccaatgca ctgaccactc agcagcagca gcagcagaaa      900

ctgcggcttc agaggatcca gatggagaga gagaggatta ggatgcgtca agaggagctc      960

atgaggcagg aagctgccct ctgccgacag ctccccatgg aaaccgagac catggcccct     1020

gtcaacacgc ctgccatgag cacagatatg agatctgtca ccaacagtag ctcagatcct     1080

ttcctcaatg gagggcccta tcattcacgg gagcagagca cagacagtgg cctggggtta     1140

gggtgctaca gtgtccccac aactccagaa gacttcctca gcaacatgga cgagatggat     1200

acaggtgaaa attccggtca gacacccatg accgtcaatc cccagcagac ccgcttccct     1260

gatttcctgg actgccttcc aggaacaaat gttgacctcg ggactttgga gtctgaagat     1320

ctgatccctc tcttcaatga tgtagagtct gctctgaaca aaagcgagcc ctttctaacc     1380

tggctgtaat cactactgtt gtaacgtgat gcagctgtga gctgacgcgc gtcttgggcc     1440

ttgcggacca agtgatgagg cagagcgggc ctgcagctgc accacgttct gcctttgtac     1500

tcacactcct tgtccgtgtg gccacttaat cattgcctgg tgttgattcg caggaacttg     1560

cgttacacag aaataaatac tctcttttca ttttcaaaaa aaaaaaaaaa                1610


<210>  16
<211>  395
<212>  PRT
<213>  Mus musculus

<400>  16

Met Asn Pro Ser Ser Val Pro His Pro Leu Pro Pro Pro Gly Gln Gln 
1               5                   10                  15      


Val Ile His Val Thr Gln Asp Leu Asp Thr Asp Leu Glu Ala Leu Phe 
            20                  25                  30          


Asn Ser Val Met Asn Pro Lys Pro Ser Ser Trp Arg Lys Lys Ile Leu 
        35                  40                  45              


Pro Glu Ser Phe Phe Lys Glu Pro Asp Ser Gly Ser His Ser Arg Gln 
    50                  55                  60                  


Ser Ser Thr Asp Ser Ser Gly Gly His Pro Gly Pro Arg Leu Ala Gly 
65                  70                  75                  80  


Gly Ala Gln His Val Arg Ser His Ser Ser Pro Ala Ser Leu Gln Leu 
                85                  90                  95      


Gly Thr Gly Ala Gly Ala Ala Gly Gly Pro Ala Gln Gln His Ala His 
            100                 105                 110         


Leu Arg Gln Gln Ser Tyr Asp Val Thr Asp Glu Leu Pro Leu Pro Pro 
        115                 120                 125             


Gly Trp Glu Met Thr Phe Thr Ala Thr Gly Gln Arg Tyr Phe Leu Asn 
    130                 135                 140                 


His Ile Glu Lys Ile Thr Thr Trp Gln Asp Pro Arg Lys Val Met Asn 
145                 150                 155                 160 


Gln Pro Leu Asn His Val Asn Leu His Pro Ser Ile Thr Ser Thr Ser 
                165                 170                 175     


Val Pro Gln Arg Ser Met Ala Val Ser Gln Pro Asn Leu Ala Met Asn 
            180                 185                 190         


His Gln His Gln Gln Val Val Ala Thr Ser Leu Ser Pro Gln Asn His 
        195                 200                 205             


Pro Thr Gln Asn Gln Pro Thr Gly Leu Met Ser Val Pro Asn Ala Leu 
    210                 215                 220                 


Thr Thr Gln Gln Gln Gln Gln Gln Lys Leu Arg Leu Gln Arg Ile Gln 
225                 230                 235                 240 


Met Glu Arg Glu Arg Ile Arg Met Arg Gln Glu Glu Leu Met Arg Gln 
                245                 250                 255     


Glu Ala Ala Leu Cys Arg Gln Leu Pro Met Glu Thr Glu Thr Met Ala 
            260                 265                 270         


Pro Val Asn Thr Pro Ala Met Ser Thr Asp Met Arg Ser Val Thr Asn 
        275                 280                 285             


Ser Ser Ser Asp Pro Phe Leu Asn Gly Gly Pro Tyr His Ser Arg Glu 
    290                 295                 300                 


Gln Ser Thr Asp Ser Gly Leu Gly Leu Gly Cys Tyr Ser Val Pro Thr 
305                 310                 315                 320 


Thr Pro Glu Asp Phe Leu Ser Asn Met Asp Glu Met Asp Thr Gly Glu 
                325                 330                 335     


Asn Ser Gly Gln Thr Pro Met Thr Val Asn Pro Gln Gln Thr Arg Phe 
            340                 345                 350         


Pro Asp Phe Leu Asp Cys Leu Pro Gly Thr Asn Val Asp Leu Gly Thr 
        355                 360                 365             


Leu Glu Ser Glu Asp Leu Ile Pro Leu Phe Asn Asp Val Glu Ser Ala 
    370                 375                 380                 


Leu Asn Lys Ser Glu Pro Phe Leu Thr Trp Leu 
385                 390                 395 


