                         SEQUENCE LISTING

<110>  KUFE, Donald
       KHARBANDA, Surender
 
<120>  ANTIBODIES AGAINST THE MUC1-C/EXTRACELLULAR DOMAIN (MUC1-C/ECD)

<130>  GENU.P0032WO

<160>  83    

<170>  PatentIn version 3.5

<210>  1
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  1

Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn 
1               5                   10                  15      


Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala 
            20                  25                  30          


Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val Pro 
        35                  40                  45              


Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro Gly Trp Gly Ile 
    50                  55                  60                  


Ala Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala Ile Val Tyr 
65                  70                  75                  80  


Leu Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln 
                85                  90                  95      


Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu Tyr 
            100                 105                 110         


Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp 
        115                 120                 125             


Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser Leu 
    130                 135                 140                 


Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 
145                 150                 155             


<210>  2
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  2

Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn 
1               5                   10                  15      


Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala 
            20                  25                  30          


Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val Pro 
        35                  40                  45              


Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly 
    50                  55              


<210>  3
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  3

Gly Phe Ser Leu Thr Thr Tyr Gly 
1               5               


<210>  4
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  4

Ile Trp Ser Asp Gly Ser Thr 
1               5           


<210>  5
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  5

Ala Lys Asn Tyr Leu Gly Ser Leu Asp Tyr 
1               5                   10  


<210>  6
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  6

Glu Tyr Glu Phe Pro Ser His Asp 
1               5               


<210>  7
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  7

Ile Asn Ser Asp Gly Gly Ser Thr 
1               5               


<210>  8
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  8

Val Arg Leu Tyr Tyr Gly Asn Val Met Asp Tyr 
1               5                   10      


<210>  9
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  9

Gln Ser Leu Val His Asn Asn Gly Asp Thr Tyr 
1               5                   10      


<210>  10
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  10

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  11
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  11

Ser Gln Thr Thr His Val Pro Leu Thr 
1               5                   


<210>  12
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  12

Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  13
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  13

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  14
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  14

Ser Gln Ser Thr His Val Pro Leu Thr 
1               5                   


<210>  15
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  15

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Glu Ser Asn Glu Tyr Glu Phe Pro Ser His 
            20                  25                  30          


Asp Met Ser Trp Val Arg Lys Thr Pro Glu Lys Arg Leu Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Asn Ser Asp Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Met 
    50                  55                  60                  


Glu Arg Arg Phe Ile Ile Ser Arg Asp Asn Thr Lys Lys Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Leu Tyr Tyr Gly Asn Val Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  16
<211>  354
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic oligonucleotide

<400>  16
gaggtgcagc tggtggagtc tgggggaggc ttagtgcagc ctggagagtc cctgaaactc       60

tcctgtgaat ccaatgaata cgaattccct tcccatgaca tgtcttgggt ccgcaagact      120

ccggagaaga ggctggagtt ggtcgcagcc attaatagtg atggtggtag cacctactat      180

ccagacacca tggagagacg attcatcatc tccagagaca ataccaagaa gaccctgtac      240

ctgcaaatga gcagtctgag gtctgaggac acagccttgt attactgtgt aagactctac      300

tatggtaatg ttatggacta ctggggtcaa ggaacctcag tcaccgtctc ctca            354


<210>  17
<211>  116
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  17

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Met Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Thr Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Val Val Ile Trp Ser Asp Gly Ser Thr Thr Tyr Asn Ser Pro Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Asn Tyr Leu Gly Ser Leu Asp Tyr Trp Gly Gln Gly Thr Ser Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  18
<211>  348
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic oligonucleotide

<400>  18
caggtgcagc tgaaggagtc aggacctggc ctggtggcgc cctcgcagag cctgtccatg       60

acatgcaccg tctcagggtt ttcattaact acctatggtg ttcactgggt tcgccagcct      120

ccaggaaagg gtctggagtg gctggtagtg atatggagtg atggaagcac aacctataat      180

tcacctctca agtccagact gagcatcagc agggacaact ccaagagcca agtattctta      240

aaaatgaaca gtctccaagc tgatgacaca gccatctact actgtgccaa aaattacctc      300

ggtagtctgg actactgggg tcagggaacc tcagtcaccg tctcctca                   348


<210>  19
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  19

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  20
<211>  260
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic oligonucleotide

<400>  20
tcagagcctt gtacacagta atggaaacac ctatttatat tggtacctac agaagccagg       60

ccagtctcca aagctcctga tctacaaagt ttccaaccga ttttctgggg tcccagacag      120

gttcagtggc agtggatcag ggacagattt cacactcaag atcagcagag tggaggctga      180

ggatctggga gtttatttct gctctcaaag tacacatgtt cctctcacgt tcggtgctgg      240

gaccaagctg gagctgaaac                                                  260


<210>  21
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  21

Asp Val Val Leu Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Asn 
            20                  25                  30          


Asn Gly Asp Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Thr 
                85                  90                  95      


Thr His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  22
<211>  337
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic oligonucleotide

<400>  22
gatgttgtgt tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gagccttgta cacaataatg gagacaccta tttacattgg      120

tacctgcaga agccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac attcaagatc      240

agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaactac acatgttccg      300

ctcacgttcg gtgctgggac caagctggag ctgaaac                               337


<210>  23
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  23

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Thr Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Ser Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Leu Ser Leu Glu Thr Ser Ala Ser Thr Thr Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Val Arg Gly Thr Gly Gly Asp Asp Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser Ala Lys Thr Thr Pro 
        115                 120 


<210>  24
<211>  360
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic oligonucleotide

<400>  24
cagatccagt tggtgcagtc tggacctgag ctgaagaagc ctggagagac agtcaagacc       60

tcctgcaagg cctctggtta taccttcaca ggctattcaa tgcactgggt gaagcaggct      120

ccaggaaagg gtttaaagtg gatgggctgg ataaacactg agactggtga gccaacatat      180

gcagatgact tcaagggacg gtttgccttg tctctggaaa cctctgccag cactacctat      240

ttgcagatca acaacctcaa aaatgaggac acggctacat atttctgtgt tagggggacg      300

gggggtgacg actggggcca aggcaccact ctcacagtct cctcagccaa aacgacaccc      360


<210>  25
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  25

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Asn Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Gly 
                85                  90                  95      


Thr His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Ala Asp Ala Ala Pro Thr Val 
        115                 120 


<210>  26
<211>  360
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic oligonucleotide

<400>  26
gatgttgtga tgacccaaac tccgctctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttacattgg      120

taccttcaga agccaggcca gtctccaaag ctcctgatct acaaagtttc caaccggttt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

aacagagtgg aggctgagga tctgggagtt tatttctgct ctcaaggtac acatgttcct      300

ccgacgttcg gtggaggcac caagctggaa atcaaacggg ctgatgctgc accaactgta      360


<210>  27
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  27

Gly Tyr Thr Phe Thr Gly Tyr Ser Met His 
1               5                   10  


<210>  28
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  28

Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Asp Asp Phe Lys Gly 
1               5                   10                  15      


<210>  29
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  29

Gly Thr Gly Gly Asp Asp 
1               5       


<210>  30
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  30

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  31
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  31

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  32
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  32

Ser Gln Gly Thr His Val Pro Pro Thr 
1               5                   


<210>  33
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  33

Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn 
1               5                   10                  15      


Val His Asp Val Glu Thr 
            20          


<210>  34
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  34

Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr 
1               5                   10                  15      


Asn Leu Thr Ile Ser Asp 
            20          


<210>  35
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  35

Thr Ile Ser Asp Val Ser Val Ser Asp Val Pro Phe Pro Phe Ser Ala 
1               5                   10                  15      


Gln Ser Gly Ala Gly 
            20      


<210>  36
<211>  58
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide (mutant ECD-L6A)

<400>  36

Ser Val Val Val Gln Ala Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn 
1               5                   10                  15      


Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala 
            20                  25                  30          


Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val Pro 
        35                  40                  45              


Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly 
    50                  55              


<210>  37
<211>  58
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide (mutant ECD-L8A)

<400>  37

Ser Val Val Val Gln Leu Thr Ala Ala Phe Arg Glu Gly Thr Ile Asn 
1               5                   10                  15      


Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala 
            20                  25                  30          


Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val Pro 
        35                  40                  45              


Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly 
    50                  55              


<210>  38
<211>  58
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide (mutant ECD-L6,8A)

<400>  38

Ser Val Val Val Gln Ala Thr Ala Ala Phe Arg Glu Gly Thr Ile Asn 
1               5                   10                  15      


Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala 
            20                  25                  30          


Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val Pro 
        35                  40                  45              


Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly 
    50                  55              


<210>  39
<211>  58
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide (mutant ECD-Q23V)

<400>  39

Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn 
1               5                   10                  15      


Val His Asp Val Glu Thr Val Phe Asn Gln Tyr Lys Thr Glu Ala Ala 
            20                  25                  30          


Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val Pro 
        35                  40                  45              


Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly 
    50                  55              


<210>  40
<211>  58
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  40

Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn 
1               5                   10                  15      


Val His Asp Val Glu Thr Gln Phe Asn Val Tyr Lys Thr Glu Ala Ala 
            20                  25                  30          


Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val Pro 
        35                  40                  45              


Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly 
    50                  55              


<210>  41
<211>  58
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide (mutant ECD-N36A)

<400>  41

Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn 
1               5                   10                  15      


Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala 
            20                  25                  30          


Ser Arg Tyr Ala Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val Pro 
        35                  40                  45              


Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly 
    50                  55              


<210>  42
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  42

Gly His Thr Phe Thr Ser Tyr Trp Met His 
1               5                   10  


<210>  43
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  43

Glu Ile Asn Pro Ser Asn Gly Arg Thr Tyr Tyr Asn Glu Asn Phe Lys 
1               5                   10                  15      


Thr 
    


<210>  44
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  44

Asp Gly Asp Tyr Val Ser Gly Phe Ala Tyr 
1               5                   10  


<210>  45
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  45

Gly Phe Ser Leu Ser Thr Ser Gly Met Gly Val Ser 
1               5                   10          


<210>  46
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  46

His Ile Tyr Trp Asp Asp Lys Arg Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15  


<210>  47
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  47

Gly Val Ser Ser Trp Phe Pro Tyr 
1               5               


<210>  48
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  48

Gly Phe Thr Phe Asn Tyr Phe Trp Ile Glu 
1               5                   10  


<210>  49
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  49

Glu Ile Leu Pro Gly Thr Gly Ser Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  50
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  50

Tyr Asp Tyr Thr Ser Ser Met Asp Tyr 
1               5                   


<210>  51
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  51

Cys Arg Ala Ser Glu Ser Val Gln Tyr Ser Gly Thr Ser Leu Met His 
1               5                   10                  15      


<210>  52
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  52

Gly Ala Ser Asn Val Glu Thr 
1               5           


<210>  53
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  53

Gln Gln Asn Trp Lys Val Pro Trp Thr 
1               5                   


<210>  54
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  54

Cys Lys Ala Ser Gln Ser Val Gly Asn Tyr Val Ala 
1               5                   10          


<210>  55
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  55

Phe Ala Ser Asn Arg Tyr Ser 
1               5           


<210>  56
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  56

Gln Gln His Tyr Ile Phe Pro Tyr Thr 
1               5                   


<210>  57
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  57

Cys Lys Ala Ser Glu Asn Val Gly Thr Tyr Val Ser 
1               5                   10          


<210>  58
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  58

Gly Ala Ser Asn Arg Tyr Thr 
1               5           


<210>  59
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  59

Gly Gln Ser Tyr Ser Tyr Pro Trp Thr 
1               5                   


<210>  60
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  60

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ile Gly Phe Thr Phe Asn Tyr Phe 
            20                  25                  30          


Trp Ile Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Thr Gly Ser Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Ile Phe Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Tyr Asp Tyr Thr Ser Ser Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  61
<211>  355
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic oligonucleotide

<400>  61
caggttcagc tgcagcagtc tggagctgag ctgatgaagc ctggggcctc agtgaaaatt       60

tcctgcaagg ctattggctt cacattcaat tacttctgga tagagtgggt aaaacagagg      120

cctgggcatg gccttgagtg gattggagag attttacctg gaactggtag tactaactac      180

aatgagaagt tcaagggcaa ggccatattc actgcagata catcctccaa cacagcctac      240

atgcaactcc gcagcctgac atctgaggac tctgccgtct attactgtgt aagatacgac      300

tatacctctt ctatggacta ctggggtcaa ggaacctcag tcaccgtctc ctcag           355


<210>  62
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  62

Asn Ile Val Met Thr Gln Ser Pro Lys Ser Met Ser Met Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Thr Cys Lys Ala Ser Glu Asn Val Gly Thr Tyr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Pro Glu Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Asn Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Tyr Cys Gly Gln Ser Tyr Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  63
<211>  322
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic oligonucleotide

<400>  63
aacattgtaa tgacccaatc tcccaaatcc atgtccatgt cagtaggaga gagggtcacc       60

ttgacctgca aggccagtga gaatgtgggt acttatgtat cctggtatca acagaaacca      120

gagcagtctc ctaaactact gatatacggg gcatccaacc ggtacactgg ggtccccaat      180

cgcttcacgg gcagtggatc tgcaacagat ttcactctga ccatcagcag tgtgcaggct      240

gaagaccttg cagattatta ctgtggacag agttacagct atccgtggac gttcggtgga      300

ggcaccaagc tggaaatcaa ac                                               322


<210>  64
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  64

Gln Ile Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Ser Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ser His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Ser Ile Ser Lys Asp Thr Ser Arg Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Thr Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Pro Gly Val Ser Ser Trp Phe Pro Tyr Trp Gly Pro Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  65
<211>  355
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic oligonucleotide

<400>  65
cagattactc tgaaagagtc tggccctggg atattgcagc cctcccagac cctcagtctg       60

acttgttctt tctctgggtt ttcactgagc acttctggta tgggtgtgag ctggattcgt      120

cagccttcag gaaagggtct ggaatggctg tcacacattt actgggatga tgacaagcgc      180

tataacccat ccctgaagag ccgactctca atctccaagg atacctccag aaaccaggta      240

ttcctcaaga tcaccagtgt ggacactgca gatactgcca catactactg tgctcccggc      300

gtatcctcat ggtttcctta ctggggccca gggactctgg tcactgtctc tgcag           355


<210>  66
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  66

Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Pro Val Ser Ala Gly 
1               5                   10                  15      


Asp Arg Val Thr Val Thr Cys Lys Ala Ser Gln Ser Val Gly Asn Tyr 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Phe Ala Ser Asn Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Val 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln His Tyr Ile Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  67
<211>  322
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic oligonucleotide

<400>  67
agtattgtga tgacccagac tcccaaattc ctgcctgtat cagcaggaga cagggttacc       60

gtgacctgca aggccagtca gagtgtgggt aattatgtag cctggtacca acagaagcca      120

ggacagtctc ctaaactact gatatacttt gcatccaatc gctatagtgg agtccctgat      180

cgcttcactg gcagtggatc tgggacagat ttcactttca ccatcagcag tgtgcaggtt      240

gaagacctgg cagtttattt ctgtcagcag cattatatct ttccgtatac gttcggatcg      300

gggaccaagc tggaaataaa ac                                               322


<210>  68
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  68

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Glu Lys Leu Ser Cys Lys Ala Ser Gly His Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Tyr Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Thr Lys Ala Thr Leu Thr Val Asp Lys Tyr Ser Ser Ser Ala Ser 
65                  70                  75                  80  


Met Gln Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Asp Gly Asp Tyr Val Ser Gly Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  69
<211>  358
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic oligonucleotide

<400>  69
caggtccaac tgcagcagcc tggggctgaa ctggtgaagc ctggggcttc agagaagctg       60

tcctgcaagg cttctgggca caccttcacc agctactgga tgcactgggt gaagcagagg      120

cctggacaag gccttgagtg gattggagag attaatccta gcaacggtcg tacttactac      180

aatgagaact tcaagaccaa ggccacactg actgtagaca aatattccag ctcagcctcc      240

atgcaactcc gcagcctgac atctgaggac tctgcggtct attactgtgc aagtgatggt      300

gactacgtct cgggctttgc ctactggggc caaggcacca ctctcacagt ctcctcag        358


<210>  70
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  70

Asp Ile Val Leu Thr Gln Ser Pro Gly Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Ser Val Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Gln Tyr Ser 
            20                  25                  30          


Gly Thr Ser Leu Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Gly Ala Ser Asn Val Glu Thr Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln Asn Trp 
                85                  90                  95      


Lys Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  71
<211>  334
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic oligonucleotide

<400>  71
gacattgtgc tcacccaatc tccaggttct ttggctgtgt ctctagggca gagtgtcacc       60

atctcctgca gagccagtga aagtgttcaa tattctggca ctagtttaat gcactggtat      120

caacagaaac caggacagcc acccaaactc ctcatctatg gtgcatccaa cgtagagact      180

ggggtccctg ccaggtttag tggcagtggg tctgggacag acttcagcct caacatccat      240

cctgtggagg aggatgatat tgcaatgtat ttctgtcagc aaaattggaa ggttccttgg      300

acgttcggtg gaggcaccaa gctggaaatc aaac                                  334


<210>  72
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  72
caggttcagc tgcagcagtc tggggctgag ctggtgaggc ctgggtcctc agtgaagatt       60

tcctgcaaga cttctggcta tgcattcagt aacttctgga tgaactgggt gaagcagagg      120

cctggacagg gtctagagtg gattggacag atttatcctg gagatggtga cactaactac      180

aatggaaagt tcaagggtaa agccacactg actgcagaca aatcctccag cacagcctac      240

atgcagctca gcagtctaac atctgaggcc tctgcggtct atttctgtgc aaggtcctac      300

tataggtcgg cctggtttgc ttactggggc caagggactc tggtctctgt ctctgca         357


<210>  73
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  73

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Ala Phe Ser Asn Phe 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Ala Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Tyr Tyr Arg Ser Ala Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Ser Val Ser Ala 
        115                 


<210>  74
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  74
gacatcttgc taactcagtc tccagccatc ctgtctgtga gtccaggaga aagagtcagt       60

ttctcctgca gggccagtca gagcattggc acaagcatac actggtatca gcaaagaaca      120

aatggttctc caaggcttct cataaagtat gcttctgagt ctatctctgg gatcccttcc      180

aggtttagtg gcagtggatc agggacagat tttactctta gcatcaacag tgtggagtct      240

gaagatattg cagattatta ctgtcaacaa agtaataact ggccactcac gttcggtgct      300

gggaccaagc tggagctgaa a                                                321


<210>  75
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  75

Asp Ile Leu Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Ser 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Ser Asn Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  76
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  76

Asn Phe Trp Met Asn 
1               5   


<210>  77
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  77

Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  78
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  78

Ser Tyr Tyr Arg Ser Ala Trp Phe Ala Tyr 
1               5                   10  


<210>  79
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  79

Arg Ala Ser Gln Ser Ile Gly Thr Ser Ile His 
1               5                   10      


<210>  80
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  80

Tyr Ala Ser Glu Ser Ile Ser 
1               5           


<210>  81
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  81

Gln Gln Ser Asn Asn Trp Pro Leu Thr 
1               5                   


<210>  82
<211>  138
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  82

Met Glu Trp Pro Cys Ile Phe Leu Phe Leu Leu Ser Val Thr Glu Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg 
            20                  25                  30          


Pro Gly Ser Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Ala Phe 
        35                  40                  45              


Ser Asn Phe Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn 
65                  70                  75                  80  


Gly Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Ala Ser Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Arg Ser Tyr Tyr Arg Ser Ala Trp Phe Ala Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Ser Val Ser Ala 
    130                 135             


<210>  83
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  83

Met Val Ser Thr Pro Gln Phe Leu Val Phe Leu Leu Phe Trp Ile Pro 
1               5                   10                  15      


Ala Ser Arg Gly Asp Ile Leu Leu Thr Gln Ser Pro Ala Ile Leu Ser 
            20                  25                  30          


Val Ser Pro Gly Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Ile Gly Thr Ser Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro 
    50                  55                  60                  


Arg Leu Leu Ile Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn 
                85                  90                  95      


Ser Val Glu Ser Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Ser Asn 
            100                 105                 110         


Asn Trp Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125         


