                         SEQUENCE LISTING

<110>  University of Copenhagen
       Evolva AG
 
<120>  Biosynthesis of forskolin and related compounds

<130>  P3460PC00

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  492
<212>  PRT
<213>  Coleus forskohlii

<400>  1

Met Glu Thr Ile Thr Leu Leu Leu Ala Leu Phe Phe Ile Ala Leu Thr 
1               5                   10                  15      


Tyr Phe Ile Ser Ser Arg Arg Arg Arg Asn Leu Pro Pro Gly Pro Phe 
            20                  25                  30          


Pro Leu Pro Ile Ile Gly Asn Met Leu Gln Leu Gly Ser Lys Pro His 
        35                  40                  45              


Gln Ser Phe Ala Gln Leu Ser Lys Lys Tyr Gly Pro Leu Met Ser Ile 
    50                  55                  60                  


His Leu Gly Ser Leu Tyr Thr Val Ile Val Ser Ser Pro Glu Met Ala 
65                  70                  75                  80  


Lys Glu Ile Leu Gln Lys His Gly Gln Val Phe Ser Gly Arg Thr Ile 
                85                  90                  95      


Ala Gln Ala Val His Ala Cys Asp His Asp Lys Ile Ser Met Gly Phe 
            100                 105                 110         


Leu Pro Val Ala Asn Thr Trp Arg Asp Met Arg Lys Ile Cys Lys Glu 
        115                 120                 125             


Gln Met Phe Ser His His Ser Leu Glu Ala Ser Glu Glu Leu Arg His 
    130                 135                 140                 


Gln Lys Leu Gln Gln Leu Leu Asp Tyr Ala Gln Lys Cys Cys Glu Ala 
145                 150                 155                 160 


Gly Arg Ala Val Asp Ile Arg Glu Ala Ser Phe Ile Thr Thr Leu Asn 
                165                 170                 175     


Leu Met Ser Ala Thr Met Phe Ser Thr Gln Ala Thr Glu Phe Asp Ser 
            180                 185                 190         


Glu Ala Thr Lys Glu Phe Lys Glu Ile Ile Glu Gly Val Ala Thr Ile 
        195                 200                 205             


Val Gly Val Ala Asn Phe Ala Asp Tyr Phe Pro Ile Leu Lys Pro Phe 
    210                 215                 220                 


Asp Leu Gln Gly Ile Lys Arg Arg Ala Asp Gly Tyr Phe Gly Arg Leu 
225                 230                 235                 240 


Leu Lys Leu Ile Glu Gly Tyr Leu Asn Glu Arg Leu Glu Ser Arg Arg 
                245                 250                 255     


Leu Asn Pro Asp Ala Pro Arg Lys Lys Asp Phe Leu Glu Thr Leu Val 
            260                 265                 270         


Asp Ile Ile Glu Ala Asn Glu Tyr Lys Leu Thr Thr Glu His Leu Thr 
        275                 280                 285             


His Leu Met Leu Asp Leu Phe Val Gly Gly Ser Glu Thr Asn Thr Thr 
    290                 295                 300                 


Ser Leu Glu Trp Ile Met Ser Glu Leu Val Ile Asn Pro Asp Lys Met 
305                 310                 315                 320 


Ala Lys Val Lys Glu Glu Leu Lys Ser Val Val Gly Asp Glu Lys Leu 
                325                 330                 335     


Val Asn Glu Ser Asp Met Pro Arg Leu Pro Tyr Leu Gln Ala Val Ile 
            340                 345                 350         


Lys Glu Val Leu Arg Ile His Pro Pro Gly Pro Leu Leu Leu Pro Arg 
        355                 360                 365             


Lys Ala Glu Ser Asp Gln Val Val Asn Gly Tyr Leu Ile Pro Lys Gly 
    370                 375                 380                 


Thr Gln Ile Leu Phe Asn Ala Trp Ala Met Gly Arg Asp Pro Thr Ile 
385                 390                 395                 400 


Trp Lys Asp Pro Glu Ser Phe Glu Pro Glu Arg Phe Leu Asn Gln Ser 
                405                 410                 415     


Ile Asp Phe Lys Gly Gln Asp Phe Glu Leu Ile Pro Phe Gly Ser Gly 
            420                 425                 430         


Arg Arg Ile Cys Pro Gly Met Pro Leu Ala Asn Arg Ile Leu His Met 
        435                 440                 445             


Thr Thr Ala Thr Leu Val His Asn Phe Asp Trp Lys Leu Glu Glu Gly 
    450                 455                 460                 


Thr Ala Asp Ala Asp His Lys Gly Glu Leu Phe Gly Leu Ala Val Arg 
465                 470                 475                 480 


Arg Ala Thr Pro Leu Arg Ile Ile Pro Leu Lys Pro 
                485                 490         


<210>  2
<211>  495
<212>  PRT
<213>  Coleus forskohlii

<400>  2

Met Glu Leu Val Gln Val Ile Ala Val Val Ala Val Val Val Val Leu 
1               5                   10                  15      


Trp Ser Gln Leu Lys Arg Lys Gly Arg Lys Leu Pro Pro Gly Pro Ser 
            20                  25                  30          


Pro Leu Pro Ile Val Gly Asn Ile Phe Gln Leu Ser Gly Lys Asn Ile 
        35                  40                  45              


Asn Glu Ser Phe Ala Lys Leu Ser Lys Ile Tyr Gly Pro Val Met Ser 
    50                  55                  60                  


Leu Arg Leu Gly Ser Leu Leu Thr Val Ile Ile Ser Ser Pro Glu Met 
65                  70                  75                  80  


Ala Lys Glu Val Leu Thr Ser Lys Asp Phe Ala Asn Arg Pro Leu Thr 
                85                  90                  95      


Glu Ala Ala His Ala His Gly His Ser Lys Phe Ser Val Gly Phe Val 
            100                 105                 110         


Pro Val Ser Asp Pro Lys Trp Lys Gln Met Arg Arg Val Cys Gln Glu 
        115                 120                 125             


Glu Met Phe Ala Ser Arg Ile Leu Glu Asn Ser Gln Gln Arg Arg His 
    130                 135                 140                 


Gln Lys Leu Gln Glu Leu Ile Asp His Val Gln Glu Ser Arg Asp Ala 
145                 150                 155                 160 


Gly Arg Ala Val Thr Ile Arg Asp Pro Val Phe Ala Thr Thr Leu Asn 
                165                 170                 175     


Ile Met Ser Leu Thr Leu Phe Ser Ala Asp Ala Thr Glu Phe Ser Ser 
            180                 185                 190         


Ser Ala Thr Ala Glu Leu Arg Asp Ile Met Ala Gly Val Val Ser Val 
        195                 200                 205             


Leu Gly Ala Ala Asn Leu Ala Asp Phe Phe Pro Ile Leu Lys Tyr Phe 
    210                 215                 220                 


Asp Pro Gln Gly Met Arg Arg Lys Ala Asp Leu His Tyr Gly Arg Leu 
225                 230                 235                 240 


Ile Asp His Ile Lys Ser Arg Met Asp Lys Arg Ser Glu Leu Lys Lys 
                245                 250                 255     


Ala Asn Pro Asn His Pro Lys His Asp Asp Phe Leu Glu Lys Ile Ile 
            260                 265                 270         


Asp Ile Thr Ile Gln Arg Asn Tyr Asp Leu Thr Ile Asn Glu Ile Thr 
        275                 280                 285             


His Leu Leu Val Asp Leu Tyr Leu Ala Gly Ser Glu Ser Thr Val Met 
    290                 295                 300                 


Thr Ile Glu Trp Thr Met Ala Glu Leu Met Leu Arg Pro Glu Ser Leu 
305                 310                 315                 320 


Ala Lys Leu Lys Ala Glu Leu Arg Ser Val Met Gly Glu Arg Lys Met 
                325                 330                 335     


Ile Gln Glu Ser Asp Asp Ile Ser Arg Leu Pro Tyr Leu Asn Gly Ala 
            340                 345                 350         


Ile Lys Glu Ala Leu Arg Leu His Pro Pro Gly Pro Leu Leu Phe Ala 
        355                 360                 365             


Arg Lys Ser Glu Ile Asp Val Glu Leu Ser Gly Tyr Phe Ile Pro Lys 
    370                 375                 380                 


Gly Thr Gln Ile Leu Val Asn Glu Trp Gly Met Gly Arg Asp Pro Ser 
385                 390                 395                 400 


Val Trp Pro Asn Pro Glu Cys Phe Gln Pro Glu Arg Phe Leu Asp Lys 
                405                 410                 415     


Asn Ile Asp Tyr Lys Gly Gln Asp Pro Gln Leu Ile Pro Phe Gly Ala 
            420                 425                 430         


Gly Arg Arg Ile Cys Pro Gly Ile Pro Ile Ala His Arg Val Val His 
        435                 440                 445             


Ser Val Val Ala Ala Leu Val His Asn Phe Asp Trp Glu Phe Ala Pro 
    450                 455                 460                 


Gly Gly Ser Gln Cys Asn Asn Glu Phe Phe Thr Gly Ala Ala Leu Val 
465                 470                 475                 480 


Arg Glu Val Pro Leu Lys Leu Ile Pro Leu Asn Pro Pro Ser Ile 
                485                 490                 495 


<210>  3
<211>  496
<212>  PRT
<213>  Coleus forskohlii

<400>  3

Met Glu Phe Asp Phe Pro Ser Ala Leu Ile Phe Pro Ala Val Ser Leu 
1               5                   10                  15      


Leu Leu Leu Leu Trp Leu Thr Lys Thr Arg Lys Pro Lys Ser Asp Leu 
            20                  25                  30          


Asp Arg Ile Pro Gly Pro Arg Arg Leu Pro Leu Ile Gly Asn Leu His 
        35                  40                  45              


His Leu Ile Ser Leu Thr Pro Pro Pro Arg Leu Phe Arg Glu Met Ala 
    50                  55                  60                  


Ala Lys Tyr Gly Pro Leu Met Arg Leu Gln Leu Gly Gly Val Pro Phe 
65                  70                  75                  80  


Leu Ile Val Ser Ser Val Asp Val Ala Lys His Val Val Lys Thr Asn 
                85                  90                  95      


Asp Val Pro Phe Ala Asn Arg Pro Pro Met His Ala Ala Arg Ala Ile 
            100                 105                 110         


Thr Tyr Asn Tyr Thr Asp Ile Gly Phe Ala Pro Tyr Gly Glu Tyr Trp 
        115                 120                 125             


Arg Asn Leu Arg Lys Ile Cys Thr Leu Glu Leu Leu Ser Ala Arg Arg 
    130                 135                 140                 


Val Arg Ser Phe Arg His Ile Arg Glu Glu Glu Asn Ala Gly Val Ala 
145                 150                 155                 160 


Lys Trp Ile Ala Ser Lys Glu Gly Ser Pro Ala Asn Leu Ser Glu Arg 
                165                 170                 175     


Val Tyr Leu Ser Ser Phe Asp Ile Thr Ser Arg Ala Ser Ile Gly Lys 
            180                 185                 190         


Ala Thr Glu Glu Lys Gln Thr Leu Thr Ser Ser Ile Lys Asp Ala Met 
        195                 200                 205             


Lys Leu Gly Gly Phe Asn Val Ala Asp Leu Tyr Pro Ser Ser Lys Leu 
    210                 215                 220                 


Leu Leu Leu Ile Thr Gly Leu Asn Phe Arg Ile Gln Arg Val Phe Arg 
225                 230                 235                 240 


Lys Thr Asp Arg Ile Leu Asp Asp Leu Leu Ser Gln His Arg Ser Thr 
                245                 250                 255     


Ser Ala Thr Thr Glu Arg Pro Glu Asp Leu Val Asp Val Leu Leu Lys 
            260                 265                 270         


Tyr Gln Lys Glu Glu Thr Glu Val His Leu Asn Asn Asp Lys Ile Lys 
        275                 280                 285             


Ala Val Ile Met Asp Met Phe Leu Ala Gly Gly Glu Thr Ser Ala Thr 
    290                 295                 300                 


Ala Val Asp Trp Ala Met Ala Glu Met Ile Arg Asn Pro Thr Thr Leu 
305                 310                 315                 320 


Lys Lys Ala Gln Glu Glu Val Arg Arg Val Phe Asp Gly Lys Gly Tyr 
                325                 330                 335     


Val Asp Glu Glu Glu Phe His Glu Leu Lys Tyr Leu Lys Leu Val Ile 
            340                 345                 350         


Lys Glu Met Leu Arg Met His Pro Pro Leu Pro Phe Leu Val Pro Arg 
        355                 360                 365             


Met Asn Ser Glu Arg Cys Glu Ile Asn Gly Tyr Glu Ile Pro Ala Asn 
    370                 375                 380                 


Thr Arg Leu Leu Ile Asn Ala Trp Ala Ile Gly Arg Pro Lys Tyr Trp 
385                 390                 395                 400 


Asn Asp Ala Glu Lys Phe Ile Pro Glu Arg Phe Glu Asn Ser Ser Ile 
                405                 410                 415     


Asp Phe Lys Gly Asn Asn Leu Glu Tyr Ile Pro Phe Gly Ala Gly Arg 
            420                 425                 430         


Arg Met Cys Pro Gly Met Thr Phe Gly Leu Ala Ser Val Glu Phe Thr 
        435                 440                 445             


Leu Ala Met Leu Leu Tyr His Phe Asp Trp Lys Met Pro Gln Gly Ile 
    450                 455                 460                 


Lys Leu Asp Met Thr Glu Ser Phe Gly Ala Ser Leu Lys Arg Lys His 
465                 470                 475                 480 


Asp Leu Leu Met Ile Pro Thr Leu Lys Arg Pro Leu Arg Leu Ala Pro 
                485                 490                 495     


<210>  4
<211>  500
<212>  PRT
<213>  Coleus forskohlii

<400>  4

Met Asp Phe Phe Thr Leu Leu Ala Ala Leu Phe Leu Ile Thr Leu Thr 
1               5                   10                  15      


Phe Phe Leu Phe Phe Lys Ser Glu Ser Lys Arg Arg Gly Gly Ala Asn 
            20                  25                  30          


Leu Pro Pro Gly Pro Tyr Pro Leu Pro Ile Val Gly Asn Ile Phe Gln 
        35                  40                  45              


Leu Gly Lys Lys Pro His Gln Ser Leu Ala Gln Leu Ala Lys Ile His 
    50                  55                  60                  


Gly Pro Leu Met Ser Leu His Phe Gly Ser Val Tyr Thr Val Ile Val 
65                  70                  75                  80  


Thr Ser Pro Glu Met Ala Lys Glu Ile Phe Val Lys Asn Asp Gln Ala 
                85                  90                  95      


Phe Leu Asn Arg Thr Val Val Glu Ala Val His Ala His Asp His Asp 
            100                 105                 110         


Lys Ile Ser Met Ala Phe Met Asp Val Gly Thr Glu Trp Arg Thr Leu 
        115                 120                 125             


Arg Arg Ile Cys Lys Glu Gln Met Phe Ser Thr Gln Ser Leu Glu Thr 
    130                 135                 140                 


Ser Gln Gly Leu Arg Gln Glu Lys Leu Gln Gln Leu His Asp Phe Val 
145                 150                 155                 160 


Gln Arg Cys Cys Asp Ser Gly Arg Val Val Asp Ile Arg Glu Ala Ser 
                165                 170                 175     


Phe Val Thr Thr Leu Asn Leu Met Ser Ala Thr Leu Phe Ser Ile Gln 
            180                 185                 190         


Ala Thr Glu Phe Asp Ser Asn Ala Thr Glu Glu Phe Arg Glu Ile Met 
        195                 200                 205             


Glu Gly Val Ala Ser Ile Val Gly Asp Pro Asn Phe Ala Asp Tyr Phe 
    210                 215                 220                 


Pro Ile Leu Lys Arg Phe Asp Pro Gln Gly Val Lys Arg Lys Ala Glu 
225                 230                 235                 240 


Leu Tyr Phe Gly Lys Met Leu Val Leu Val Glu Asp Leu Leu Gln Lys 
                245                 250                 255     


Arg Gln Glu Glu Arg Arg Arg Ser Pro Ser Tyr Ala Lys Lys Asp Asp 
            260                 265                 270         


Leu Leu Glu Arg Leu Val Asp Val Leu Asn Glu Lys Asn Glu Tyr Lys 
        275                 280                 285             


Leu Thr Thr Lys His Ile Thr His Leu Leu Leu Asp Leu Phe Val Gly 
    290                 295                 300                 


Gly Ser Glu Thr Thr Thr Thr Ser Val Glu Trp Ile Met Ser Glu Leu 
305                 310                 315                 320 


Leu Ile Asn Pro Glu Lys Leu Ala Lys Leu Lys Glu Glu Leu Lys Thr 
                325                 330                 335     


Val Val Gly Glu Lys Lys Gln Val Gln Glu Ser Asp Ile Pro Gln Leu 
            340                 345                 350         


Pro Tyr Phe Glu Ala Val Leu Lys Glu Val Phe Arg Leu His Pro Pro 
        355                 360                 365             


Gly Pro Leu Leu Leu Pro Arg Lys Ala Glu Cys Asp Val Gln Val Gly 
    370                 375                 380                 


Ser Tyr Thr Ile Pro Lys Glu Thr Gln Ile Leu Val Asn Ala Trp Ala 
385                 390                 395                 400 


Ile Gly Arg Asp Pro Ala Ile Trp Pro Asn Pro Glu Ala Phe Glu Pro 
                405                 410                 415     


Glu Arg Phe Leu Ser Gln Lys Met Asp Tyr Lys Gly Gln Asp Phe Glu 
            420                 425                 430         


Leu Ile Pro Phe Gly Ser Gly Arg Arg Ile Cys Pro Gly Leu Ser Phe 
        435                 440                 445             


Ala Asn Arg Met Leu Pro Met Thr Val Ala Thr Leu Ile His Asn Phe 
    450                 455                 460                 


Asp Trp Lys Leu Glu Val Glu Ala Asn Ala Glu Asp Val His Lys Gly 
465                 470                 475                 480 


Glu Met Phe Gly Ile Ala Val Arg Arg Ala Val Pro Leu Arg Ala Tyr 
                485                 490                 495     


Pro Ile Gln Pro 
            500 


<210>  5
<211>  1479
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNA sequence codon optimised for expression in yeast

<400>  5
atggaaacca tcaccttgtt gttggccttg tttttcattg ctttgaccta cttcatctcc       60

tccagaagaa gaagaaattt gccaccaggt ccatttccat tgccaattat tggtaacatg      120

ttgcaattgg gttccaagcc acatcaatct tttgctcaat tgtccaaaaa gtacggtcca      180

ttgatgtcca ttcatttggg ttccttgtac accgttatag tctcttcacc agaaatggcc      240

aaagaaatct tgcaaaaaca cggtcaagtt ttctccggta gaactattgc tcaagctgtt      300

catgcttgtg atcacgataa gatttctatg ggttttttgc cagttgccaa cacttggaga      360

gatatgagaa agatctgcaa agaacaaatg ttctcccacc attctttgga agctagtgaa      420

gaattgagac accaaaagtt gcaacaatta ttagactacg ctcaaaagtg ttgcgaagct      480

ggtagagctg ttgatattag agaagcctct ttcattacca ccttgaactt gatgtctgct      540

actatgtttt ctacccaagc taccgaattt gattccgaag ctacaaaaga attcaaagaa      600

attatcgaag gtgtcgccac tatagttggt gttgctaatt ttgctgatta cttcccaatc      660

ttgaagccat ttgacttgca aggtattaag agaagagctg atggttactt cggtagatta      720

ttgaagttga tcgaaggtta cttgaacgaa agattggaat ctagaagatt gaacccagat      780

gctccaagaa agaaggattt cttggaaacc ttggttgata tcatcgaagc caacgaatac      840

aagttgacta ctgaacattt gacccacttg atgttggatt tgtttgttgg tggttctgaa      900

actaacacca catccttgga atggatcatg tctgaattgg ttatcaaccc agataagatg      960

gccaaggtca aagaagaatt gaagtctgtt gttggtgacg aaaagttggt taacgaatct     1020

gatatgccaa gattgccata cttgcaagcc gttatcaaag aagttttgag aattcatcca     1080

cctggtcctt tgttgttgcc aagaaaagct gaatctgatc aagttgttaa cggttatttg     1140

atcccaaagg gtactcaaat tttgttcaat gcttgggcta tgggtagaga tccaactatt     1200

tggaaagatc cagaatcctt cgaaccagaa agattcttga atcaatccat cgacttcaag     1260

ggtcaagact tcgaattgat tccatttggt tctggtagaa gaatctgtcc aggtatgcca     1320

ttggctaata gaatcttgca tatgactacc gccactttgg ttcataattt cgattggaaa     1380

ttggaagaag gtactgctga cgctgatcat aagggtgaat tatttggttt ggctgttaga     1440

agagctaccc cattgagaat cattccattg aaaccataa                            1479


<210>  6
<211>  1488
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNA sequence codon optimised for expression in yeast

<400>  6
atggaattgg tccaagttat cgctgttgtt gcagttgttg ttgttttgtg gtcccaattg       60

aaaagaaagg gtagaaaatt gccaccaggt ccatctccat tgccaatagt tggtaatatc      120

ttccaattgt ccggtaagaa catcaacgaa tctttcgcta agttgtccaa aatctacggt      180

ccagttatgt ctttgagatt gggttctttg ttgaccgtca ttatctcttc accagaaatg      240

gccaaagaag tcttgacttc taaggatttt gctaacagac cattgactga agctgctcat      300

gctcatggtc attctaaatt ttctgttggt ttcgttccag tctctgatcc aaaatggaaa      360

caaatgagaa gagtctgcca agaagaaatg ttcgcctcta gaattttgga aaactcccaa      420

caaagaagac accaaaagtt gcaagaattg atcgaccacg ttcaagaatc tagagatgct      480

ggtagagctg ttactattag agatccagtt ttcgctacca ccttgaacat tatgtccttg      540

actttgtttt ctgccgatgc tactgaattc tcttcttctg ctactgctga attgagagat      600

attatggctg gtgttgtttc tgttttgggt gctgctaatt tggctgattt cttcccaatc      660

ttgaaatact tcgatccaca aggtatgaga agaaaggctg acttgcatta cggtagattg      720

attgaccata tcaagtccag aatggacaag agatctgaat tgaagaaggc taatccaaac      780

catccaaagc acgatgattt cttggaaaag atcatcgaca tcaccattca aagaaactac      840

gacttgacca ttaacgaaat cacccatttg ttggtcgact tgtatttggc tggttctgaa      900

tctactgtta tgaccattga atggaccatg gccgaattga tgttaagacc agaatcattg      960

gctaaattga aggcagaatt gagatccgtt atgggtgaaa gaaagatgat ccaagaatcc     1020

gacgacattt ctagattgcc atacttaaac ggtgctatca aagaagcctt aagattgcat     1080

ccacctggtc ctttgttgtt tgctagaaag tctgaaatcg atgttgaatt gtctggttac     1140

ttcatcccaa agggtactca aatcttggtt aatgaatggg gtatgggtag agatccttct     1200

gtttggccta atccagaatg ttttcaacca gaaagatttt tggataagaa cattgactac     1260

aagggtcaag acccacaatt gattccattt ggtgcaggta gaagaatttg tccaggtatt     1320

ccaattgccc atagagttgt tcattcagtt gttgctgctt tggttcataa cttcgattgg     1380

gaatttgctc ctggtggttc tcaatgtaac aacgaatttt tcactggtgc tgccttggtt     1440

agagaagttc cattgaagtt gattcctttg aacccaccat ccatctga                  1488


<210>  7
<211>  773
<212>  PRT
<213>  Coleus forskohlii

<400>  7

Met Lys Met Leu Met Ile Lys Ser Gln Phe Arg Val His Ser Ile Val 
1               5                   10                  15      


Ser Ala Trp Ala Asn Asn Ser Asn Lys Arg Gln Ser Leu Gly His Gln 
            20                  25                  30          


Ile Arg Arg Lys Gln Arg Ser Gln Val Thr Glu Cys Arg Val Ala Ser 
        35                  40                  45              


Leu Asp Ala Leu Asn Gly Ile Gln Lys Val Gly Pro Ala Thr Ile Gly 
    50                  55                  60                  


Thr Pro Glu Glu Glu Asn Lys Lys Ile Glu Asp Ser Ile Glu Tyr Val 
65                  70                  75                  80  


Lys Glu Leu Leu Lys Thr Met Gly Asp Gly Arg Ile Ser Val Ser Pro 
                85                  90                  95      


Tyr Asp Thr Ala Ile Val Ala Leu Ile Lys Asp Leu Glu Gly Gly Asp 
            100                 105                 110         


Gly Pro Glu Phe Pro Ser Cys Leu Glu Trp Ile Ala Gln Asn Gln Leu 
        115                 120                 125             


Ala Asp Gly Ser Trp Gly Asp His Phe Phe Cys Ile Tyr Asp Arg Val 
    130                 135                 140                 


Val Asn Thr Ala Ala Cys Val Val Ala Leu Lys Ser Trp Asn Val His 
145                 150                 155                 160 


Ala Asp Lys Ile Glu Lys Gly Ala Val Tyr Leu Lys Glu Asn Val His 
                165                 170                 175     


Lys Leu Lys Asp Gly Lys Ile Glu His Met Pro Ala Gly Phe Glu Phe 
            180                 185                 190         


Val Val Pro Ala Thr Leu Glu Arg Ala Lys Ala Leu Gly Ile Lys Gly 
        195                 200                 205             


Leu Pro Tyr Asp Asp Pro Phe Ile Arg Glu Ile Tyr Ser Ala Lys Gln 
    210                 215                 220                 


Thr Arg Leu Thr Lys Ile Pro Lys Gly Met Ile Tyr Glu Ser Pro Thr 
225                 230                 235                 240 


Ser Leu Leu Tyr Ser Leu Asp Gly Leu Glu Gly Leu Glu Trp Asp Lys 
                245                 250                 255     


Ile Leu Lys Leu Gln Ser Ala Asp Gly Ser Phe Ile Thr Ser Val Ser 
            260                 265                 270         


Ser Thr Ala Phe Val Phe Met His Thr Asn Asp Leu Lys Cys His Ala 
        275                 280                 285             


Phe Ile Lys Asn Ala Leu Thr Asn Cys Asn Gly Gly Val Pro His Thr 
    290                 295                 300                 


Tyr Pro Val Asp Ile Phe Ala Arg Leu Trp Ala Val Asp Arg Leu Gln 
305                 310                 315                 320 


Arg Leu Gly Ile Ser Arg Phe Phe Glu Pro Glu Ile Lys Tyr Leu Met 
                325                 330                 335     


Asp His Ile Asn Asn Val Trp Arg Glu Lys Gly Val Phe Ser Ser Arg 
            340                 345                 350         


His Ser Gln Phe Ala Asp Ile Asp Asp Thr Ser Met Gly Ile Arg Leu 
        355                 360                 365             


Leu Lys Met His Gly Tyr Asn Val Asn Pro Asn Ala Leu Glu His Phe 
    370                 375                 380                 


Lys Gln Lys Asp Gly Lys Phe Thr Cys Tyr Ala Asp Gln His Ile Glu 
385                 390                 395                 400 


Ser Pro Ser Pro Met Tyr Asn Leu Tyr Arg Ala Ala Gln Leu Arg Phe 
                405                 410                 415     


Pro Gly Glu Glu Ile Leu Gln Gln Ala Leu Gln Phe Ala Tyr Asn Phe 
            420                 425                 430         


Leu His Glu Asn Leu Ala Ser Asn His Phe Gln Glu Lys Trp Val Ile 
        435                 440                 445             


Ser Asp His Leu Ile Asp Glu Val Arg Ile Gly Leu Lys Met Pro Trp 
    450                 455                 460                 


Tyr Ala Thr Leu Pro Arg Val Glu Ala Ser Tyr Tyr Leu Gln His Tyr 
465                 470                 475                 480 


Gly Gly Ser Ser Asp Val Trp Ile Gly Lys Thr Leu Tyr Arg Met Pro 
                485                 490                 495     


Glu Ile Ser Asn Asp Thr Tyr Lys Ile Leu Ala Gln Leu Asp Phe Asn 
            500                 505                 510         


Lys Cys Gln Ala Gln His Gln Leu Glu Trp Met Ser Met Lys Glu Trp 
        515                 520                 525             


Tyr Gln Ser Asn Asn Val Lys Glu Phe Gly Ile Ser Lys Lys Glu Leu 
    530                 535                 540                 


Leu Leu Ala Tyr Phe Leu Ala Ala Ala Thr Met Phe Glu Pro Glu Arg 
545                 550                 555                 560 


Thr Gln Glu Arg Ile Met Trp Ala Lys Thr Gln Val Val Ser Arg Met 
                565                 570                 575     


Ile Thr Ser Phe Leu Asn Lys Glu Asn Thr Met Ser Phe Asp Leu Lys 
            580                 585                 590         


Ile Ala Leu Leu Thr Gln Pro Gln His Gln Ile Asn Gly Ser Glu Met 
        595                 600                 605             


Lys Asn Gly Leu Ala Gln Thr Leu Pro Ala Ala Phe Arg Gln Leu Leu 
    610                 615                 620                 


Lys Glu Phe Asp Lys Tyr Thr Arg His Gln Leu Arg Asn Thr Trp Asn 
625                 630                 635                 640 


Lys Trp Leu Met Lys Leu Lys Gln Gly Asp Asp Asn Gly Gly Ala Asp 
                645                 650                 655     


Ala Glu Leu Leu Ala Asn Thr Leu Asn Ile Cys Ala Gly His Asn Glu 
            660                 665                 670         


Asp Ile Leu Ser His Tyr Glu Tyr Thr Ala Leu Ser Ser Leu Thr Asn 
        675                 680                 685             


Lys Ile Cys Gln Arg Leu Ser Gln Ile Gln Asp Lys Lys Met Leu Glu 
    690                 695                 700                 


Ile Glu Glu Gly Ser Ile Lys Asp Lys Glu Met Glu Leu Glu Ile Gln 
705                 710                 715                 720 


Thr Leu Val Lys Leu Val Leu Gln Glu Thr Ser Gly Gly Ile Asp Arg 
                725                 730                 735     


Asn Ile Lys Gln Thr Phe Leu Ser Val Phe Lys Thr Phe Tyr Tyr Arg 
            740                 745                 750         


Ala Tyr His Asp Ala Lys Thr Ile Asp Ala His Ile Phe Gln Val Leu 
        755                 760                 765             


Phe Glu Pro Val Val 
    770             


<210>  8
<211>  598
<212>  PRT
<213>  Coleus forskohlii

<400>  8

Met Ser Ser Leu Ala Gly Asn Leu Arg Val Ile Pro Phe Ser Gly Asn 
1               5                   10                  15      


Arg Val Gln Thr Arg Thr Gly Ile Leu Pro Val His Gln Thr Pro Met 
            20                  25                  30          


Ile Thr Ser Lys Ser Ser Ala Ala Val Lys Cys Ser Leu Thr Thr Pro 
        35                  40                  45              


Thr Asp Leu Met Gly Lys Ile Lys Glu Val Phe Asn Arg Glu Val Asp 
    50                  55                  60                  


Thr Ser Pro Ala Ala Met Thr Thr His Ser Thr Asp Ile Pro Ser Asn 
65                  70                  75                  80  


Leu Cys Ile Ile Asp Thr Leu Gln Arg Leu Gly Ile Asp Gln Tyr Phe 
                85                  90                  95      


Gln Ser Glu Ile Asp Ala Val Leu His Asp Thr Tyr Arg Leu Trp Gln 
            100                 105                 110         


Leu Lys Lys Lys Asp Ile Phe Ser Asp Ile Thr Thr His Ala Met Ala 
        115                 120                 125             


Phe Arg Leu Leu Arg Val Lys Gly Tyr Glu Val Ala Ser Asp Glu Leu 
    130                 135                 140                 


Ala Pro Tyr Ala Asp Gln Glu Arg Ile Asn Leu Gln Thr Ile Asp Val 
145                 150                 155                 160 


Pro Thr Val Val Glu Leu Tyr Arg Ala Ala Gln Glu Arg Leu Thr Glu 
                165                 170                 175     


Glu Asp Ser Thr Leu Glu Lys Leu Tyr Val Trp Thr Ser Ala Phe Leu 
            180                 185                 190         


Lys Gln Gln Leu Leu Thr Asp Ala Ile Pro Asp Lys Lys Leu His Lys 
        195                 200                 205             


Gln Val Glu Tyr Tyr Leu Lys Asn Tyr His Gly Ile Leu Asp Arg Met 
    210                 215                 220                 


Gly Val Arg Arg Asn Leu Asp Leu Tyr Asp Ile Ser His Tyr Lys Ser 
225                 230                 235                 240 


Leu Lys Ala Ala His Arg Phe Tyr Asn Leu Ser Asn Glu Asp Ile Leu 
                245                 250                 255     


Ala Phe Ala Arg Gln Asp Phe Asn Ile Ser Gln Ala Gln His Gln Lys 
            260                 265                 270         


Glu Leu Gln Gln Leu Gln Arg Trp Tyr Ala Asp Cys Arg Leu Asp Thr 
        275                 280                 285             


Leu Lys Phe Gly Arg Asp Val Val Arg Ile Gly Asn Phe Leu Thr Ser 
    290                 295                 300                 


Ala Met Ile Gly Asp Pro Glu Leu Ser Asp Leu Arg Leu Ala Phe Ala 
305                 310                 315                 320 


Lys His Ile Val Leu Val Thr Arg Ile Asp Asp Phe Phe Asp His Gly 
                325                 330                 335     


Gly Pro Lys Glu Glu Ser Tyr Glu Ile Leu Glu Leu Val Lys Glu Trp 
            340                 345                 350         


Lys Glu Lys Pro Ala Gly Glu Tyr Val Ser Glu Glu Val Glu Ile Leu 
        355                 360                 365             


Phe Thr Ala Val Tyr Asn Thr Val Asn Glu Leu Ala Glu Met Ala His 
    370                 375                 380                 


Ile Glu Gln Gly Arg Ser Val Lys Asp Leu Leu Val Lys Leu Trp Val 
385                 390                 395                 400 


Glu Ile Leu Ser Val Phe Arg Ile Glu Leu Asp Thr Trp Thr Asn Asp 
                405                 410                 415     


Thr Ala Leu Thr Leu Glu Glu Tyr Leu Ser Gln Ser Trp Val Ser Ile 
            420                 425                 430         


Gly Cys Arg Ile Cys Ile Leu Ile Ser Met Gln Phe Gln Gly Val Lys 
        435                 440                 445             


Leu Ser Asp Glu Met Leu Gln Ser Glu Glu Cys Thr Asp Leu Cys Arg 
    450                 455                 460                 


Tyr Val Ser Met Val Asp Arg Leu Leu Asn Asp Val Gln Thr Phe Glu 
465                 470                 475                 480 


Lys Glu Arg Lys Glu Asn Thr Gly Asn Ser Val Ser Leu Leu Gln Ala 
                485                 490                 495     


Ala His Lys Asp Glu Arg Val Ile Asn Glu Glu Glu Ala Cys Ile Lys 
            500                 505                 510         


Val Lys Glu Leu Ala Glu Tyr Asn Arg Arg Lys Leu Met Gln Ile Val 
        515                 520                 525             


Tyr Lys Thr Gly Thr Ile Phe Pro Arg Lys Cys Lys Asp Leu Phe Leu 
    530                 535                 540                 


Lys Ala Cys Arg Ile Gly Cys Tyr Leu Tyr Ser Ser Gly Asp Glu Phe 
545                 550                 555                 560 


Thr Ser Pro Gln Gln Met Met Glu Asp Met Lys Ser Leu Val Tyr Glu 
                565                 570                 575     


Pro Leu Pro Ile Ser Pro Pro Glu Ala Asn Asn Ala Ser Gly Glu Lys 
            580                 585                 590         


Met Ser Cys Val Ser Asn 
        595             


<210>  9
<211>  587
<212>  PRT
<213>  Coleus forskohlii

<400>  9

Met Ser Ile Thr Ile Asn Leu Arg Val Ile Ala Phe Pro Gly His Gly 
1               5                   10                  15      


Val Gln Ser Arg Gln Gly Ile Phe Ala Val Met Glu Phe Pro Arg Asn 
            20                  25                  30          


Lys Asn Thr Phe Lys Ser Ser Phe Ala Val Lys Cys Ser Leu Ser Thr 
        35                  40                  45              


Pro Thr Asp Leu Met Gly Lys Ile Lys Glu Lys Leu Ser Glu Lys Val 
    50                  55                  60                  


Asp Asn Ser Val Ala Ala Met Ala Thr Asp Ser Ala Asp Met Pro Thr 
65                  70                  75                  80  


Asn Leu Cys Ile Val Asp Ser Leu Gln Arg Leu Gly Val Glu Lys Tyr 
                85                  90                  95      


Phe Gln Ser Glu Ile Asp Thr Val Leu Asp Asp Ala Tyr Arg Leu Trp 
            100                 105                 110         


Gln Leu Lys Gln Lys Asp Ile Phe Ser Asp Ile Thr Thr His Ala Met 
        115                 120                 125             


Ala Phe Arg Leu Leu Arg Val Lys Gly Tyr Asp Val Ser Ser Glu Glu 
    130                 135                 140                 


Leu Ala Pro Tyr Ala Asp Gln Glu Gly Met Asn Leu Gln Thr Ile Asp 
145                 150                 155                 160 


Leu Ala Ala Val Ile Glu Leu Tyr Arg Ala Ala Gln Glu Arg Val Ala 
                165                 170                 175     


Glu Glu Asp Ser Thr Leu Glu Lys Leu Tyr Val Trp Thr Ser Thr Phe 
            180                 185                 190         


Leu Lys Gln Gln Leu Leu Ala Gly Ala Ile Pro Asp Gln Lys Leu His 
        195                 200                 205             


Lys Gln Val Glu Tyr Tyr Leu Lys Asn Tyr His Gly Ile Leu Asp Arg 
    210                 215                 220                 


Met Gly Val Arg Lys Gly Leu Asp Leu Tyr Asp Ala Gly Tyr Tyr Lys 
225                 230                 235                 240 


Ala Leu Lys Ala Ala Asp Arg Leu Val Asp Leu Cys Asn Glu Asp Leu 
                245                 250                 255     


Leu Ala Phe Ala Arg Gln Asp Phe Asn Ile Asn Gln Ala Gln His Arg 
            260                 265                 270         


Lys Glu Leu Glu Gln Leu Gln Arg Trp Tyr Ala Asp Cys Arg Leu Asp 
        275                 280                 285             


Lys Leu Glu Phe Gly Arg Asp Val Val Arg Val Ser Asn Phe Leu Thr 
    290                 295                 300                 


Ser Ala Ile Leu Gly Asp Pro Glu Leu Ser Glu Val Arg Leu Val Phe 
305                 310                 315                 320 


Ala Lys His Ile Val Leu Val Thr Arg Ile Asp Asp Phe Phe Asp His 
                325                 330                 335     


Gly Gly Pro Arg Glu Glu Ser His Lys Ile Leu Glu Leu Ile Lys Glu 
            340                 345                 350         


Trp Lys Glu Lys Pro Ala Gly Glu Tyr Val Ser Lys Glu Val Glu Ile 
        355                 360                 365             


Leu Tyr Thr Ala Val Tyr Asn Thr Val Asn Glu Leu Ala Glu Arg Ala 
    370                 375                 380                 


Asn Val Glu Gln Gly Arg Asn Val Glu Pro Phe Leu Arg Thr Leu Trp 
385                 390                 395                 400 


Val Gln Ile Leu Ser Ile Phe Lys Ile Glu Leu Asp Thr Trp Ser Asp 
                405                 410                 415     


Asp Thr Ala Leu Thr Leu Asp Asp Tyr Leu Asn Asn Ser Trp Val Ser 
            420                 425                 430         


Ile Gly Cys Arg Ile Cys Ile Leu Met Ser Met Gln Phe Ile Gly Met 
        435                 440                 445             


Lys Leu Pro Glu Glu Met Leu Leu Ser Glu Glu Cys Val Asp Leu Cys 
    450                 455                 460                 


Arg His Val Ser Met Val Asp Arg Leu Leu Asn Asp Val Gln Thr Phe 
465                 470                 475                 480 


Glu Lys Glu Arg Lys Glu Asn Thr Gly Asn Ala Val Ser Leu Leu Leu 
                485                 490                 495     


Ala Ala His Lys Gly Glu Arg Ala Phe Ser Glu Glu Glu Ala Ile Ala 
            500                 505                 510         


Lys Ala Lys Tyr Leu Ala Asp Cys Asn Arg Arg Ser Leu Met Gln Ile 
        515                 520                 525             


Val Tyr Lys Thr Gly Thr Ile Phe Pro Arg Lys Cys Lys Asp Met Phe 
    530                 535                 540                 


Leu Lys Val Cys Arg Ile Gly Cys Tyr Leu Tyr Ala Ser Gly Asp Glu 
545                 550                 555                 560 


Phe Thr Ser Pro Gln Gln Met Met Glu Asp Met Lys Ser Leu Val Tyr 
                565                 570                 575     


Glu Pro Leu Gln Ile His Pro Pro Pro Ala Asn 
            580                 585         


<210>  10
<211>  493
<212>  PRT
<213>  Coleus forskohlii

<400>  10

Met Glu Ser Met Asn Ala Leu Val Val Gly Leu Leu Leu Ile Ala Leu 
1               5                   10                  15      


Thr Ile Leu Phe Ser Leu Arg Arg Arg Arg Asn Leu Ala Pro Gly Pro 
            20                  25                  30          


Tyr Pro Phe Pro Ile Ile Gly Asn Met Leu Gln Leu Gly Thr Lys Pro 
        35                  40                  45              


His Gln Ser Phe Ala Gln Leu Ser Lys Lys Tyr Gly Pro Leu Met Ser 
    50                  55                  60                  


Ile His Leu Gly Ser Leu Tyr Thr Val Ile Val Ser Ser Pro Glu Met 
65                  70                  75                  80  


Ala Lys Glu Ile Leu Gln Lys His Gly Gln Val Phe Ser Gly Arg Thr 
                85                  90                  95      


Ile Ala Gln Ala Val His Ala Cys Asp His Asp Lys Ile Ser Met Gly 
            100                 105                 110         


Phe Leu Pro Val Ser Asn Thr Trp Arg Asp Met Arg Lys Ile Cys Lys 
        115                 120                 125             


Glu Gln Met Phe Ser His His Ser Leu Glu Gly Ser Gln Gly Leu Arg 
    130                 135                 140                 


Gln Gln Lys Leu Leu Gln Leu Leu Asp Tyr Ala Gln Lys Cys Cys Glu 
145                 150                 155                 160 


Thr Gly Arg Ala Val Asp Ile Arg Glu Ala Ser Phe Ile Thr Thr Leu 
                165                 170                 175     


Asn Leu Met Ser Ala Thr Met Phe Ser Thr Gln Ala Thr Glu Phe Glu 
            180                 185                 190         


Ser Lys Ser Thr Gln Glu Phe Lys Glu Ile Ile Glu Gly Val Ala Thr 
        195                 200                 205             


Ile Val Gly Val Ala Asn Phe Gly Asp Tyr Phe Pro Ile Leu Lys Pro 
    210                 215                 220                 


Phe Asp Leu Gln Gly Ile Lys Arg Lys Ala Asp Gly Tyr Phe Gly Arg 
225                 230                 235                 240 


Leu Leu Lys Leu Ile Glu Gly Tyr Leu Asn Glu Arg Leu Glu Ser Arg 
                245                 250                 255     


Lys Ser Asn Pro Asn Ala Pro Arg Lys Asn Asp Phe Leu Glu Thr Val 
            260                 265                 270         


Val Asp Ile Leu Glu Ala Asn Glu Tyr Lys Leu Ser Val Asp His Leu 
        275                 280                 285             


Thr His Leu Met Leu Asp Leu Phe Val Gly Gly Ser Glu Thr Asn Thr 
    290                 295                 300                 


Thr Ser Leu Glu Trp Thr Met Ser Glu Leu Val Asn Asn Pro Asp Lys 
305                 310                 315                 320 


Met Ala Lys Leu Lys Gln Glu Leu Lys Ser Val Val Gly Glu Arg Lys 
                325                 330                 335     


Leu Val Asp Glu Ser Glu Met Pro Arg Leu Pro Tyr Leu Gln Ala Val 
            340                 345                 350         


Ile Lys Glu Ser Leu Arg Ile His Pro Pro Gly Pro Leu Leu Leu Pro 
        355                 360                 365             


Arg Lys Ala Glu Thr Asp Gln Glu Val Asn Gly Tyr Leu Ile Pro Lys 
    370                 375                 380                 


Gly Thr Gln Ile Leu Phe Asn Val Trp Ala Met Gly Arg Asp Pro Ser 
385                 390                 395                 400 


Ile Trp Lys Asp Pro Glu Ser Phe Glu Pro Glu Arg Phe Leu Asn Gln 
                405                 410                 415     


Asn Ile Asp Phe Lys Gly Gln Asp Phe Glu Leu Ile Pro Phe Gly Ser 
            420                 425                 430         


Gly Arg Arg Ile Cys Pro Gly Met Pro Leu Ala Asn Arg Ile Leu His 
        435                 440                 445             


Met Ala Thr Ala Thr Met Val His Asn Phe Asp Trp Lys Leu Glu Gln 
    450                 455                 460                 


Gly Thr Asp Glu Ala Asp Ala Lys Gly Glu Leu Phe Gly Leu Ala Val 
465                 470                 475                 480 


Arg Arg Ala Val Pro Leu Arg Ile Ile Pro Leu Gln Pro 
                485                 490             


<210>  11
<211>  493
<212>  PRT
<213>  Coleus forskohlii

<400>  11

Met Glu Thr Met Thr Leu Leu Leu Pro Leu Phe Phe Ile Ala Leu Thr 
1               5                   10                  15      


Tyr Phe Leu Ser Trp Arg Arg Arg Arg Asn Leu Pro Pro Gly Pro Phe 
            20                  25                  30          


Pro Leu Pro Ile Ile Gly Asn Leu Leu Gln Ile Gly Ser Lys Pro His 
        35                  40                  45              


Gln Ser Phe Ala Gln Leu Ser Lys Lys Tyr Gly Pro Leu Met Ser Val 
    50                  55                  60                  


Gln Leu Gly Ser Val Tyr Thr Val Ile Ala Ser Ser Pro Glu Met Ala 
65                  70                  75                  80  


Lys Glu Ile Leu Gln Lys His Gly Gln Val Phe Ser Gly Arg Thr Ile 
                85                  90                  95      


Ala Gln Ala Ala Gln Ala Cys Gly His Asp Gln Ile Ser Ile Gly Phe 
            100                 105                 110         


Leu Pro Val Ala Thr Thr Trp Arg Asp Met Arg Lys Ile Cys Lys Glu 
        115                 120                 125             


Gln Met Phe Ser His His Ser Leu Glu Ser Ser Lys Glu Leu Arg His 
    130                 135                 140                 


Glu Lys Leu Gln Lys Leu Leu Asp Tyr Ala Gln Lys Cys Cys Glu Ala 
145                 150                 155                 160 


Gly Arg Ala Val Asp Ile Arg Glu Ala Ala Phe Ile Thr Thr Leu Asn 
                165                 170                 175     


Leu Met Ser Ala Thr Leu Phe Ser Thr Gln Ala Thr Glu Phe Asp Ser 
            180                 185                 190         


Glu Ala Thr Lys Glu Phe Lys Glu Val Ile Glu Gly Val Ala Val Ile 
        195                 200                 205             


Val Gly Glu Pro Asn Phe Ala Asp Tyr Phe Pro Ile Leu Lys Pro Phe 
    210                 215                 220                 


Asp Leu Gln Gly Ile Lys Arg Arg Ala Asn Ser Tyr Phe Gly Arg Leu 
225                 230                 235                 240 


Leu Lys Leu Met Glu Arg Tyr Leu Asn Glu Arg Leu Glu Ser Arg Arg 
                245                 250                 255     


Leu Asn Pro Asp Ala Pro Lys Lys Asn Asp Phe Leu Glu Thr Leu Val 
            260                 265                 270         


Asp Ile Ile Gln Ala Asp Glu Tyr Lys Leu Thr Thr Asp His Val Thr 
        275                 280                 285             


His Leu Met Leu Asp Leu Phe Val Gly Gly Ser Glu Thr Ser Ala Thr 
    290                 295                 300                 


Ser Leu Glu Trp Ile Met Ser Glu Leu Val Ser Asn Pro Ser Lys Leu 
305                 310                 315                 320 


Ala Lys Val Lys Ala Glu Leu Lys Ser Val Val Gly Glu Lys Lys Val 
                325                 330                 335     


Val Ser Glu Ser Glu Met Ala Arg Leu Pro Tyr Leu Gln Ala Val Ile 
            340                 345                 350         


Lys Glu Val Leu Arg Leu His Pro Pro Gly Pro Leu Leu Leu Pro Arg 
        355                 360                 365             


Lys Ala Gly Ser Asp Gln Val Val Asn Gly Tyr Leu Ile Pro Lys Gly 
    370                 375                 380                 


Thr Gln Leu Leu Phe Asn Val Trp Ala Met Gly Arg Asp Pro Ser Ile 
385                 390                 395                 400 


Trp Lys Asn Pro Glu Ser Phe Glu Pro Glu Arg Phe Leu Asn Gln Asn 
                405                 410                 415     


Ile Asp Tyr Lys Gly Gln Asp Phe Glu Leu Ile Pro Phe Gly Ser Gly 
            420                 425                 430         


Arg Arg Ile Cys Pro Gly Met Pro Leu Ala Asp Arg Ile Met His Met 
        435                 440                 445             


Thr Thr Ala Thr Leu Val His Asn Phe Asp Trp Lys Leu Glu Asp Gly 
    450                 455                 460                 


Ala Gly Asp Ala Asp His Lys Gly Asp Asp Pro Phe Gly Leu Ala Ile 
465                 470                 475                 480 


Arg Arg Ala Thr Pro Leu Arg Ile Ile Pro Leu Lys Pro 
                485                 490             


<210>  12
<211>  1482
<212>  DNA
<213>  Coleus forskohlii

<400>  12
atggaaacca tgactcttct cctccctctt ttcttcatcg ctctgacata tttcctctcc       60

tggaggcgcc ggagaaacct tcctccgggg ccttttcctc ttccaatcat cggaaacttg      120

ctgcaaatcg gctccaaacc ccaccagtca ttcgcccaac tctcaaagaa atatgggcct      180

ctcatgtccg tccaactcgg gagtgtatac accgtgatag cctcctcccc ggaaatggcg      240

aaagagatac tgcaaaaaca cggccaagtg ttttccggga gaaccatcgc acaggcggcg      300

caagcgtgcg gccacgacca gatctccatc gggtttctgc cggtggcaac cacgtggcgt      360

gatatgcgta aaatatgcaa agaacagatg ttctcgcatc acagcctgga atccagcaag      420

gagctgaggc acgagaagct gcagaagctg ctggactacg cccagaaatg ctgcgaagcc      480

ggccgtgccg ttgatattcg tgaggccgcc ttcattacaa cgctcaacct catgtctgcc      540

acgttgttct cgactcaagc tactgagttc gactccgaag ctacaaaaga gtttaaggag      600

gtcatcgagg gggtggccgt cattgtgggt gagcctaatt tcgctgacta cttccccatc      660

ttgaagcctt tcgatcttca ggggatcaag cgtagagcta atagctactt tggaagactg      720

ctcaagttaa tggagagata tctgaatgag aggctggaat caagaaggtt gaacccagat      780

gcccccaaga agaatgactt tttggaaacc ctggtggata tcatccaggc tgatgaatac      840

aagctcacga ccgaccacgt cacgcacctc atgcttgact tatttgttgg aggatcggaa      900

acaagcgcga cctcactgga atggataatg tcggagttag tgagcaatcc gagtaaattg      960

gcgaaggtga aagcggagct caagagcgtt gtaggagaaa agaaagtggt gagcgaatca     1020

gaaatggcga ggctgccata cttgcaagca gtgatcaaag aagtgctccg acttcaccct     1080

cccggccctc ttctgcttcc tcgcaaggca gggagtgatc aagttgtgaa tggatacctg     1140

atcccaaagg gaactcaatt actcttcaat gtatgggcaa tgggcagaga ccccagtatc     1200

tggaagaatc ctgaatcttt cgagcccgag cgcttcctca atcaaaacat agactacaaa     1260

ggccaagatt tcgagctcat tccattcggg tccgggagaa gaatttgccc cggtatgccg     1320

ctggcggatc ggattatgca catgacgacg gccactctgg ttcacaactt cgattggaaa     1380

ctggaagacg gagcaggtga tgcggatcac aagggagacg accccttcgg cttggccatc     1440

cgccgtgcaa ctcctctcag gatcattcca cttaagccat ga                        1482


<210>  13
<211>  1482
<212>  DNA
<213>  Coleus forskohlii

<400>  13
atggaaagca tgaatgctct tgtcgtcggt ctcttgttga tcgctttgac aattttgttt       60

tcgttgaggc ggcggagaaa ccttgctccg gggccttatc cttttccgat catcggaaac      120

atgcttcaac tgggcacgaa accacaccaa tcattcgccc agctgtcgaa gaaatatggg      180

ccgctcatgt ccatccacct gggaagttta tacacagtga tcgtttcgtc gccggaaatg      240

gcgaaagaga tcctgcaaaa gcacggccaa gtgttttcag ggagaaccat cgctcaggcg      300

gtgcatgcat gcgaccacga caagatctcc atggggtttc tgccggtgtc gaacacgtgg      360

cgcgatatgc gtaaaatatg caaagagcag atgttctcgc atcacagctt ggaaggcagc      420

cagggtctcc gccagcagaa gctgctgcag ctgctcgact acgcccagaa gtgctgcgaa      480

accggccgcg ccgttgacat tcgtgaggct tccttcatca caactctcaa cctcatgtcg      540

gccaccatgt tttcgactca agctaccgag tttgaatcga aatctactca ggagttcaag      600

gagatcattg aaggcgtggc cacgattgtg ggcgtggcta atttcggaga ctacttccca      660

atcttgaagc ctttcgatct gcaggggatc aagagaaaag ctgatggcta cttcggcaga      720

ttgctgaaat taatcgaggg ctatctcaat gaaagattgg aatccagaaa atcgaaccca      780

aatgccccca gaaagaatga ctttttggaa acagtggtcg atatcctcga ggcaaatgag      840

tacaagttgt cagtcgacca cctcacgcat ctcatgctgg atttgtttgt tggaggatcg      900

gaaacaaaca cgacctcact ggagtggaca atgtcggagt tagtgaacaa ccccgacaaa      960

atggccaagc tgaaacagga gctgaagagc gttgtaggag agaggaaact ggtggatgag     1020

tcggagatgc cgaggctgcc atatctgcaa gctgtcatca aagaatcgct ccgaattcac     1080

ccaccgggcc ctcttcttct ccctcgcaaa gcagagaccg atcaagaggt gaatggatat     1140

ctcatcccaa aagggactca gattctcttc aatgtgtggg caatgggcag ggatcctagc     1200

atctggaagg atcctgaatc ttttgagccc gagcgcttcc tcaatcaaaa catagacttc     1260

aaaggccaag atttcgagct cattccattc gggtcgggcc gaagaatctg ccccggcatg     1320

ccgctggcca atcggattct ccacatggcc accgcgacta tggttcataa cttcgattgg     1380

aaactggaac aaggaacaga tgaagctgat gccaaaggag agttgtttgg attggccgtg     1440

cgcagggcag ttcccctcag gatcattcca cttcagcctt aa                        1482


