                         SEQUENCE LISTING

<110>  UNIVERSITY HEALTH NETWORK
 
<120>  METHODS AND COMPOSITIONS FOR PRODUCING A CELL EXPRESSING A T CELL
       RECEPTOR

<130>  10723-P45386PC00

<150>  61/933,048
<151>  2014-01-29

<160>  124   

<170>  PatentIn version 3.5

<210>  1
<211>  810
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1
atgatgcggc ccatcgtgct ggtgctgctg ttcgccacaa gcgccctggc ccagaaagag       60

gtggaacaga acagcggccc tctgagcgtg cccgagggcg ccattgccag cctgaactgc      120

acctacagcg accggggctc ccagagcttc ttctggtaca gacagtacag cggcaagagc      180

cccgagctga tcatgttcat ctacagcaac ggcgacaaag aggacggccg gttcaccgcc      240

cagctgaaca aggccagcca gtacgtgtcc ctgctgatcc gggacagcca gcccagcgac      300

agcgccacct acctgtgtgc cgtgtccatc ggcttcggca acgtgctgca ctgcggcagc      360

ggcacccagg tcatcgtgct gcccaacatc cagaaccccg accccgccgt gtaccagctg      420

cgggacagca agagcagcga caagagcgtg tgcctgttca ccgactttga cagccagacc      480

aacgtgtccc agagcaagga cagcgacgtg tacatcaccg ataagacagt gctggacatg      540

cggagcatgg acttcaagag caacagcgcc gtggcctggt ccaacaagag cgacttcgcc      600

tgcgccaacg ccttcaacaa cagcatcatc cccgaggaca cattcttccc aagccccgag      660

agcagctgcg acgtgaagct ggtggaaaag agcttcgaga cagacaccaa cctgaacttc      720

cagaacctga gcgtgatcgg cttcagaatc ctgctgctga aggtggccgg cttcaacctg      780

ctgatgaccc tgcggctgtg gtcctcgtga                                       810


<210>  2
<211>  269
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2

Met Met Arg Pro Ile Val Leu Val Leu Leu Phe Ala Thr Ser Ala Leu 
1               5                   10                  15      


Ala Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu 
            20                  25                  30          


Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln 
        35                  40                  45              


Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile 
    50                  55                  60                  


Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala 
65                  70                  75                  80  


Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser 
                85                  90                  95      


Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val Ser Ile Gly Phe 
            100                 105                 110         


Gly Asn Val Leu His Cys Gly Ser Gly Thr Gln Val Ile Val Leu Pro 
        115                 120                 125             


Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys 
    130                 135                 140                 


Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr 
145                 150                 155                 160 


Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr 
                165                 170                 175     


Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala 
            180                 185                 190         


Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser 
        195                 200                 205             


Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp 
    210                 215                 220                 


Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe 
225                 230                 235                 240 


Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala 
                245                 250                 255     


Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 


<210>  3
<211>  927
<212>  DNA
<213>  Homo Sapien

<400>  3
atgggccccc agctccttgg ctatgtggtc ctttgccttc taggagcagg ccccctggaa       60

gcccaagtga cccagaaccc aagatacctc atcacagtga ctggaaagaa gttaacagtg      120

acttgttctc agaatatgaa ccatgagtat atgtcctggt atcgacaaga cccagggctg      180

ggcttaaggc agatctacta ttcaatgaat gttgaggtga ctgataaggg agatgttcct      240

gaagggtaca aagtctctcg aaaagagaag aggaatttcc ccctgatcct ggagtcgccc      300

agccccaacc agacctctct gtacttctgt gccagcagtc tactcgggga ctatggctac      360

accttcggtt cggggaccag gttaaccgtt gtagaggacc tgaacaaggt gttcccaccc      420

gaggtcgctg tgtttgagcc atcagaagca gagatctccc acacccaaaa ggccacactg      480

gtgtgcctgg ccacaggctt cttccctgac cacgtggagc tgagctggtg ggtgaatggg      540

aaggaggtgc acagtggggt cagcacggac ccgcagcccc tcaaggagca gcccgccctc      600

aatgactcca gatactgcct gagcagccgc ctgagggtct cggccacctt ctggcagaac      660

ccccgcaacc acttccgctg tcaagtccag ttctacgggc tctcggagaa tgacgagtgg      720

acccaggata gggccaaacc cgtcacccag atcgtcagcg ccgaggcctg gggtagagca      780

gactgtggct ttacctcggt gtcctaccag caaggggtcc tgtctgccac catcctctat      840

gagatcctgc tagggaaggc caccctgtat gctgtgctgg tcagcgccct tgtgttgatg      900

gccatggtca agagaaagga tttctga                                          927


<210>  4
<211>  308
<212>  PRT
<213>  Homo Sapien

<400>  4

Met Gly Pro Gln Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr 
            20                  25                  30          


Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln 
    50                  55                  60                  


Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro 
65                  70                  75                  80  


Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile 
                85                  90                  95      


Leu Glu Ser Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Leu Leu Gly Asp Tyr Gly Tyr Thr Phe Gly Ser Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Val Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val 
    130                 135                 140                 


Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln 
            180                 185                 190         


Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser 
        195                 200                 205             


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His 
    210                 215                 220                 


Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp 
225                 230                 235                 240 


Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala 
                245                 250                 255     


Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly 
            260                 265                 270         


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
        275                 280                 285             


Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys 
    290                 295                 300                 


Arg Lys Asp Phe 
305             


<210>  5
<211>  933
<212>  DNA
<213>  Homo Sapien

<400>  5
atgggccccc agctccttgg ctatgtggtc ctttgccttc taggagcagg ccccctggaa       60

gcccaagtga cccagaaccc aagatacctc atcacagtga ctggaaagaa gttaacagtg      120

acttgttctc agaatatgaa ccatgagtat atgtcctggt atcgacaaga cccagggctg      180

ggcttaaggc agatctacta ttcaatgaat gttgaggtga ctgataaggg agatgttcct      240

gaagggtaca aagtctctcg aaaagagaag aggaatttcc ccctgatcct ggagtcgccc      300

agccccaacc agacctctct gtacttctgt gccagcagtt tagggggtgc ctacgagcag      360

tacttcgggc cgggcaccag gctcacggtc acagaggacc tgaaaaacgt gttcccaccc      420

gaggtcgctg tgtttgagcc atcagaagca gagatctccc acacccaaaa ggccacactg      480

gtgtgcctgg ccacaggctt ctaccccgac cacgtggagc tgagctggtg ggtgaatggg      540

aaggaggtgc acagtggggt cagcacagac ccgcagcccc tcaaggagca gcccgccctc      600

aatgactcca gatactgcct gagcagccgc ctgagggtct cggccacctt ctggcagaac      660

ccccgcaacc acttccgctg tcaagtccag ttctacgggc tctcggagaa tgacgagtgg      720

acccaggata gggccaaacc tgtcacccag atcgtcagcg ccgaggcctg gggtagagca      780

gactgtggct tcacctccga gtcttaccag caaggggtcc tgtctgccac catcctctat      840

gagatcttgc tagggaaggc caccttgtat gccgtgctgg tcagtgccct cgtgctgatg      900

gcaatggtca agagaaagga ttccagaggc tag                                   933


<210>  6
<211>  310
<212>  PRT
<213>  Homo Sapien

<400>  6

Met Gly Pro Gln Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr 
            20                  25                  30          


Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln 
    50                  55                  60                  


Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro 
65                  70                  75                  80  


Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile 
                85                  90                  95      


Leu Glu Ser Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Leu Gly Gly Ala Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val 
    130                 135                 140                 


Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln 
            180                 185                 190         


Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser 
        195                 200                 205             


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His 
    210                 215                 220                 


Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp 
225                 230                 235                 240 


Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala 
                245                 250                 255     


Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly 
            260                 265                 270         


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
        275                 280                 285             


Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys 
    290                 295                 300                 


Arg Lys Asp Ser Arg Gly 
305                 310 


<210>  7
<211>  828
<212>  DNA
<213>  Homo Sapien

<400>  7
atgatgaagt gtccacaggc tttactagct atcttttggc ttctactgag ctgggtgagc       60

agtgaagaca aggtggtaca aagccctcta tctctggttg tccacgaggg agacactgta      120

actctcaatt gcagttatga agtgactaac tttcgaagcc tactatggta caagcaggaa      180

aagaaagctc ccacatttct atttatgcta acttcaagtg gaattgaaaa gaagtcagga      240

agactaagta gcatattaga taagaaagaa cttttcagca tcctgaacat cacagccacc      300

cagaccggag actcggccgt ctacctctgt gctgtgataa ctggtggtac tagctatgga      360

aagctgacat ttggacaagg gaccatcttg actgtccatc caaatatcca gaaccctgac      420

cctgccgtgt accagctgag agactctaaa tccagtgaca agtctgtctg cctattcacc      480

gattttgatt ctcaaacaaa tgtgtcacaa agtaaggatt ctgatgtgta tatcacagac      540

aaaactgtgc tagacatgag gtctatggac ttcaagagca acagtgctgt ggcctggagc      600

aacaaatctg actttgcatg tgcaaacgcc ttcaacaaca gcattattcc agaagacacc      660

ttcttcccca gcccagaaag ttcctgtgat gtcaagctgg tcgagaaaag ctttgaaaca      720

gatacgaacc taaactttca aaacctgtca gtgattgggt tccgaatcct cctcctgaaa      780

gtggccgggt ttaatctgct catgacgctg cggctgtggt ccagctga                   828


<210>  8
<211>  275
<212>  PRT
<213>  Homo Sapien

<400>  8

Met Met Lys Cys Pro Gln Ala Leu Leu Ala Ile Phe Trp Leu Leu Leu 
1               5                   10                  15      


Ser Trp Val Ser Ser Glu Asp Lys Val Val Gln Ser Pro Leu Ser Leu 
            20                  25                  30          


Val Val His Glu Gly Asp Thr Val Thr Leu Asn Cys Ser Tyr Glu Val 
        35                  40                  45              


Thr Asn Phe Arg Ser Leu Leu Trp Tyr Lys Gln Glu Lys Lys Ala Pro 
    50                  55                  60                  


Thr Phe Leu Phe Met Leu Thr Ser Ser Gly Ile Glu Lys Lys Ser Gly 
65                  70                  75                  80  


Arg Leu Ser Ser Ile Leu Asp Lys Lys Glu Leu Phe Ser Ile Leu Asn 
                85                  90                  95      


Ile Thr Ala Thr Gln Thr Gly Asp Ser Ala Val Tyr Leu Cys Ala Val 
            100                 105                 110         


Ile Thr Gly Gly Thr Ser Tyr Gly Lys Leu Thr Phe Gly Gln Gly Thr 
        115                 120                 125             


Ile Leu Thr Val His Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr 
    130                 135                 140                 


Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr 
145                 150                 155                 160 


Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val 
                165                 170                 175     


Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys 
            180                 185                 190         


Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala 
        195                 200                 205             


Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser 
    210                 215                 220                 


Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr 
225                 230                 235                 240 


Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile 
                245                 250                 255     


Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu 
            260                 265                 270         


Trp Ser Ser 
        275 


<210>  9
<211>  831
<212>  DNA
<213>  Homo Sapien

<400>  9
atgatgaagt gtccacaggc tttactagct atcttttggc ttctactgag ctgggtgagc       60

agtgaagaca aggtggtaca aagccctcta tctctggttg tccacgaggg agacactgta      120

actctcaatt gcagttatga agtgactaac tttcgaagcc tactatggta caagcaggaa      180

aagaaagctc ccacatttct atttatgcta acttcaagtg gaattgaaaa gaagtcagga      240

agactaagta gcatattaga taagaaagaa cttttcagca tcctgaacat cacagccacc      300

cagaccggag actcagccac ttatctctgt gctgtgcaga atgctggtgg tactagctat      360

ggaaagctga catttggaca agggaccatc ttgactgtcc atccaaatat ccagaaccct      420

gaccctgccg tgtaccagct gagagactct aaatccagtg acaagtctgt ctgcctattc      480

accgattttg attctcaaac aaatgtgtca caaagtaagg attctgatgt gtatatcaca      540

gacaaaactg tgctagacat gaggtctatg gacttcaaga gcaacagtgc tgtggcctgg      600

agcaacaaat ctgactttgc atgtgcaaac gccttcaaca acagcattat tccagaagac      660

accttcttcc ccagcccaga aagttcctgt gatgtcaagc tggtcgagaa aagctttgaa      720

acagatacga acctaaactt tcaaaacctg tcagtgattg ggttccgaat cctcctcctg      780

aaagtggccg ggtttaatct gctcatgacg ctgcggctgt ggtccagctg a               831


<210>  10
<211>  276
<212>  PRT
<213>  Homo Sapien

<400>  10

Met Met Lys Cys Pro Gln Ala Leu Leu Ala Ile Phe Trp Leu Leu Leu 
1               5                   10                  15      


Ser Trp Val Ser Ser Glu Asp Lys Val Val Gln Ser Pro Leu Ser Leu 
            20                  25                  30          


Val Val His Glu Gly Asp Thr Val Thr Leu Asn Cys Ser Tyr Glu Val 
        35                  40                  45              


Thr Asn Phe Arg Ser Leu Leu Trp Tyr Lys Gln Glu Lys Lys Ala Pro 
    50                  55                  60                  


Thr Phe Leu Phe Met Leu Thr Ser Ser Gly Ile Glu Lys Lys Ser Gly 
65                  70                  75                  80  


Arg Leu Ser Ser Ile Leu Asp Lys Lys Glu Leu Phe Ser Ile Leu Asn 
                85                  90                  95      


Ile Thr Ala Thr Gln Thr Gly Asp Ser Ala Thr Tyr Leu Cys Ala Val 
            100                 105                 110         


Gln Asn Ala Gly Gly Thr Ser Tyr Gly Lys Leu Thr Phe Gly Gln Gly 
        115                 120                 125             


Thr Ile Leu Thr Val His Pro Asn Ile Gln Asn Pro Asp Pro Ala Val 
    130                 135                 140                 


Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe 
145                 150                 155                 160 


Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp 
                165                 170                 175     


Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe 
            180                 185                 190         


Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys 
        195                 200                 205             


Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro 
    210                 215                 220                 


Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu 
225                 230                 235                 240 


Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg 
                245                 250                 255     


Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg 
            260                 265                 270         


Leu Trp Ser Ser 
        275     


<210>  11
<211>  825
<212>  DNA
<213>  Homo Sapien

<400>  11
atgatgaagt gtccacaggc tttactagct atcttttggc ttctactgag ctgggtgagc       60

agtgaagaca aggtggtaca aagccctcta tctctggttg tccacgaggg agacactgta      120

actctcaatt gcagttatga agtgactaac tttcgaagcc tactatggta caagcaggaa      180

aagaaagctc ccacatttct atttatgcta acttcaagtg gaattgaaaa gaagtcagga      240

agactaagta gcatattaga taagaaagaa cttttcagca tcctgaacat cacagccacc      300

cagaccggag actcggccgt ctacctctgt gctgtgctta cccaaactgg ggcaaacaac      360

ctcttctttg ggactggaac gagactcacc gttattccct atatccagaa ccctgaccct      420

gccgtgtacc agctgagaga ctctaaatcc agtgacaagt ctgtctgcct attcaccgat      480

tttgattctc aaacaaatgt gtcacaaagt aaggattctg atgtgtatat cacagacaaa      540

actgtgctag acatgaggtc tatggacttc aagagcaaca gtgctgtggc ctggagcaac      600

aaatctgact ttgcatgtgc aaacgccttc aacaacagca ttattccaga agacaccttc      660

ttccccagcc cagaaagttc ctgtgatgtc aagctggtcg agaaaagctt tgaaacagat      720

acgaacctaa actttcaaaa cctgtcagtg attgggttcc gaatcctcct cctgaaagtg      780

gccgggttta atctgctcat gacgctgcgg ctgtggtcca gctga                      825


<210>  12
<211>  274
<212>  PRT
<213>  Homo Sapien

<400>  12

Met Met Lys Cys Pro Gln Ala Leu Leu Ala Ile Phe Trp Leu Leu Leu 
1               5                   10                  15      


Ser Trp Val Ser Ser Glu Asp Lys Val Val Gln Ser Pro Leu Ser Leu 
            20                  25                  30          


Val Val His Glu Gly Asp Thr Val Thr Leu Asn Cys Ser Tyr Glu Val 
        35                  40                  45              


Thr Asn Phe Arg Ser Leu Leu Trp Tyr Lys Gln Glu Lys Lys Ala Pro 
    50                  55                  60                  


Thr Phe Leu Phe Met Leu Thr Ser Ser Gly Ile Glu Lys Lys Ser Gly 
65                  70                  75                  80  


Arg Leu Ser Ser Ile Leu Asp Lys Lys Glu Leu Phe Ser Ile Leu Asn 
                85                  90                  95      


Ile Thr Ala Thr Gln Thr Gly Asp Ser Ala Val Tyr Leu Cys Ala Val 
            100                 105                 110         


Leu Thr Gln Thr Gly Ala Asn Asn Leu Phe Phe Gly Thr Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Ile Pro Tyr Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr 
                165                 170                 175     


Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser 
            180                 185                 190         


Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn 
        195                 200                 205             


Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro 
    210                 215                 220                 


Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp 
225                 230                 235                 240 


Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu 
                245                 250                 255     


Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp 
            260                 265                 270         


Ser Ser 
        


<210>  13
<211>  834
<212>  DNA
<213>  Homo Sapien

<400>  13
atggagaaaa tgttggagtg tgcattcata gtcttgtggc ttcagcttgg ctggttgagt       60

ggagaagacc aggtgacgca gagtcccgag gccctgagac tccaggaggg agagagtagc      120

agtctcaact gcagttacac agtcagcggt ttaagagggc tgttctggta taggcaagat      180

cctgggaaag gccctgaatt cctcttcacc ctgtattcag ctggggaaga aaaggagaaa      240

gaaaggctaa aagccacatt aacaaagaag gaaagctttc tgcacatcac agcccctaaa      300

cctgaagact cagccactta tctctgtgct gtgcaggcct taaggaataa tgctggcaac      360

aaccgtaagc tgatttgggg attgggaaca agcctggcag taaatccgaa tatccagaac      420

cctgaccctg ccgtgtacca gctgagagac tctaaatcca gtgacaagtc tgtctgccta      480

ttcaccgatt ttgattctca aacaaatgtg tcacaaagta aggattctga tgtgtatatc      540

acagacaaaa ctgtgctaga catgaggtct atggacttca agagcaacag tgctgtggcc      600

tggagcaaca aatctgactt tgcatgtgca aacgccttca acaacagcat tattccagaa      660

gacaccttct tccccagccc agaaagttcc tgtgatgtca agctggtcga gaaaagcttt      720

gaaacagata cgaacctaaa ctttcaaaac ctgtcagtga ttgggttccg aatcctcctc      780

ctgaaagtgg ccgggtttaa tctgctcatg acgctgcggc tgtggtccag ctga            834


<210>  14
<211>  277
<212>  PRT
<213>  Homo Sapien

<400>  14

Met Glu Lys Met Leu Glu Cys Ala Phe Ile Val Leu Trp Leu Gln Leu 
1               5                   10                  15      


Gly Trp Leu Ser Gly Glu Asp Gln Val Thr Gln Ser Pro Glu Ala Leu 
            20                  25                  30          


Arg Leu Gln Glu Gly Glu Ser Ser Ser Leu Asn Cys Ser Tyr Thr Val 
        35                  40                  45              


Ser Gly Leu Arg Gly Leu Phe Trp Tyr Arg Gln Asp Pro Gly Lys Gly 
    50                  55                  60                  


Pro Glu Phe Leu Phe Thr Leu Tyr Ser Ala Gly Glu Glu Lys Glu Lys 
65                  70                  75                  80  


Glu Arg Leu Lys Ala Thr Leu Thr Lys Lys Glu Ser Phe Leu His Ile 
                85                  90                  95      


Thr Ala Pro Lys Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Val Gln 
            100                 105                 110         


Ala Leu Arg Asn Asn Ala Gly Asn Asn Arg Lys Leu Ile Trp Gly Leu 
        115                 120                 125             


Gly Thr Ser Leu Ala Val Asn Pro Asn Ile Gln Asn Pro Asp Pro Ala 
    130                 135                 140                 


Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu 
145                 150                 155                 160 


Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser 
                165                 170                 175     


Asp Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp 
            180                 185                 190         


Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala 
        195                 200                 205             


Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe 
    210                 215                 220                 


Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe 
225                 230                 235                 240 


Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe 
                245                 250                 255     


Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu 
            260                 265                 270         


Arg Leu Trp Ser Ser 
        275         


<210>  15
<211>  930
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  15
atgatgcggc ccatcgtgct ggtgctgctg tttgccacat ctgccctggc cggcgtgacc       60

cagaccccta gatacctgat caagaccaga ggccagcagg tcacactgag ctgcagccct      120

atcagcggcc acagaagcgt gtcctggtat cagcagaccc caggccaggg cctgcagttc      180

ctgttcgagt acttcagcga gacacagcgg aacaagggca acttccccgg cagattcagc      240

ggcagacagt tcagcaacag ccgcagcgag atgaacgtgt ccaccctgga actgggcgac      300

agcgccctgt acctgtgtgc ctcttctctg ggctggcggg aaacctacaa cgagcagttc      360

ttcggccctg gcaccagact gaccgtgctg gaagatctga agaacgtgtt ccccccagag      420

gtggccgtgt tcgagccttc tgaggccgag atcagccaca cccagaaagc caccctcgtg      480

tgtctggcca ccggcttcta ccccgaccac gtggaactgt cttggtgggt caacggcaaa      540

gaggtgcaca gcggcgtcag caccgaccct cagcctctga aagagcagcc cgccctgaac      600

gacagccggt actgtctgag cagcagactg agagtgtccg ccaccttctg gcagaacccc      660

cggaaccact tcagatgcca ggtgcagttc tacggcctga gcgagaacga cgagtggacc      720

caggacagag ccaagcctgt gacccagatc gtgtctgccg aggcttgggg cagagccgat      780

tgcggcttta ccagcgagag ctaccagcag ggcgtgctga gcgccaccat cctgtacgag      840

atcctgctgg gcaaggccac cctgtatgcc gtgctggtgt cagccctggt gctgatggct      900

atggtcaagc ggaaggacag ccgcggctga                                       930


<210>  16
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Contruct

<400>  16

Met Met Arg Pro Ile Val Leu Val Leu Leu Phe Ala Thr Ser Ala Leu 
1               5                   10                  15      


Ala Gly Val Thr Gln Thr Pro Arg Tyr Leu Ile Lys Thr Arg Gly Gln 
            20                  25                  30          


Gln Val Thr Leu Ser Cys Ser Pro Ile Ser Gly His Arg Ser Val Ser 
        35                  40                  45              


Trp Tyr Gln Gln Thr Pro Gly Gln Gly Leu Gln Phe Leu Phe Glu Tyr 
    50                  55                  60                  


Phe Ser Glu Thr Gln Arg Asn Lys Gly Asn Phe Pro Gly Arg Phe Ser 
65                  70                  75                  80  


Gly Arg Gln Phe Ser Asn Ser Arg Ser Glu Met Asn Val Ser Thr Leu 
                85                  90                  95      


Glu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser Ser Leu Gly Trp 
            100                 105                 110         


Arg Glu Thr Tyr Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu Thr 
        115                 120                 125             


Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe 
    130                 135                 140                 


Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val 
145                 150                 155                 160 


Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp 
                165                 170                 175     


Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro 
            180                 185                 190         


Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser 
        195                 200                 205             


Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe 
    210                 215                 220                 


Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr 
225                 230                 235                 240 


Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp 
                245                 250                 255     


Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val 
            260                 265                 270         


Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu 
        275                 280                 285             


Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg 
    290                 295                 300                 


Lys Asp Ser Arg Gly 
305                 


<210>  17
<211>  18
<212>  DNA
<213>  Homo Sapien

<400>  17
gaccggggct cccagagc                                                     18


<210>  18
<211>  6
<212>  PRT
<213>  Homo Sapien

<400>  18

Asp Arg Gly Ser Gln Ser 
1               5       


<210>  19
<211>  15
<212>  DNA
<213>  Homo Sapien

<400>  19
atgaaccatg agtat                                                        15


<210>  20
<211>  5
<212>  PRT
<213>  Homo Sapien

<400>  20

Met Asn His Glu Tyr 
1               5   


<210>  21
<211>  15
<212>  DNA
<213>  Homo Sapien

<400>  21
atgaaccatg agtat                                                        15


<210>  22
<211>  5
<212>  PRT
<213>  Homo Sapien

<400>  22

Met Asn His Glu Tyr 
1               5   


<210>  23
<211>  18
<212>  DNA
<213>  Homo Sapien

<400>  23
gtgactaact ttcgaagc                                                     18


<210>  24
<211>  6
<212>  PRT
<213>  Homo Sapien

<400>  24

Val Thr Asn Phe Arg Ser 
1               5       


<210>  25
<211>  18
<212>  DNA
<213>  Homo Sapien

<400>  25
gtgactaact ttcgaagc                                                     18


<210>  26
<211>  6
<212>  PRT
<213>  Homo Sapien

<400>  26

Val Thr Asn Phe Arg Ser 
1               5       


<210>  27
<211>  18
<212>  DNA
<213>  Homo Sapien

<400>  27
gtgactaact ttcgaagc                                                     18


<210>  28
<211>  6
<212>  PRT
<213>  Homo Sapien

<400>  28

Val Thr Asn Phe Arg Ser 
1               5       


<210>  29
<211>  18
<212>  DNA
<213>  Homo Sapien

<400>  29
gtcagcggtt taagaggg                                                     18


<210>  30
<211>  6
<212>  PRT
<213>  Homo Sapien

<400>  30

Val Ser Gly Leu Arg Gly 
1               5       


<210>  31
<211>  15
<212>  DNA
<213>  Homo Sapien

<400>  31
agcggccaca gaagc                                                        15


<210>  32
<211>  5
<212>  PRT
<213>  Homo Sapien

<400>  32

Ser Gly His Arg Ser 
1               5   


<210>  33
<211>  18
<212>  DNA
<213>  Homo Sapien

<400>  33
atctacagca acggcgac                                                     18


<210>  34
<211>  6
<212>  PRT
<213>  Homo Sapien

<400>  34

Ile Tyr Ser Asn Gly Asp 
1               5       


<210>  35
<211>  18
<212>  DNA
<213>  Homo sapien

<400>  35
tcaatgaatg ttgaggtg                                                     18


<210>  36
<211>  6
<212>  PRT
<213>  Homo Sapien

<400>  36

Ser Met Asn Val Glu Val 
1               5       


<210>  37
<211>  18
<212>  DNA
<213>  Homo Sapien

<400>  37
tcaatgaatg ttgaggtg                                                     18


<210>  38
<211>  6
<212>  PRT
<213>  Homo Sapien

<400>  38

Ser Met Asn Val Glu Val 
1               5       


<210>  39
<211>  21
<212>  DNA
<213>  Homo Sapien

<400>  39
ctaacttcaa gtggaattga a                                                 21


<210>  40
<211>  7
<212>  PRT
<213>  Homo Sapien

<400>  40

Leu Thr Ser Ser Gly Ile Glu 
1               5           


<210>  41
<211>  21
<212>  DNA
<213>  Homo Sapien

<400>  41
ctaacttcaa gtggaattga a                                                 21


<210>  42
<211>  7
<212>  PRT
<213>  Homo Sapien

<400>  42

Leu Thr Ser Ser Gly Ile Glu 
1               5           


<210>  43
<211>  21
<212>  DNA
<213>  Homo Sapien

<400>  43
ctaacttcaa gtggaattga a                                                 21


<210>  44
<211>  7
<212>  PRT
<213>  Homo Sapien

<400>  44

Leu Thr Ser Ser Gly Ile Glu 
1               5           


<210>  45
<211>  21
<212>  DNA
<213>  Homo Sapien

<400>  45
ctgtattcag ctggggaaga a                                                 21


<210>  46
<211>  7
<212>  PRT
<213>  Homo Sapien

<400>  46

Leu Tyr Ser Ala Gly Glu Glu 
1               5           


<210>  47
<211>  18
<212>  DNA
<213>  Homo Sapien

<400>  47
tacttcagcg agacacag                                                     18


<210>  48
<211>  6
<212>  PRT
<213>  Homo Sapien

<400>  48

Tyr Phe Ser Glu Thr Gln 
1               5       


<210>  49
<211>  39
<212>  DNA
<213>  Homo Sapien

<400>  49
tgtgccgtgt ccatcggctt cggcaacgtg ctgcactgc                              39


<210>  50
<211>  13
<212>  PRT
<213>  Homo Sapien

<400>  50

Cys Ala Val Ser Ile Gly Phe Gly Asn Val Leu His Cys 
1               5                   10              


<210>  51
<211>  39
<212>  DNA
<213>  Homo Sapien

<400>  51
tgtgccagca gtctactcgg ggactatggc tacaccttc                              39


<210>  52
<211>  13
<212>  PRT
<213>  Homo Sapien

<400>  52

Cys Ala Ser Ser Leu Leu Gly Asp Tyr Gly Tyr Thr Phe 
1               5                   10              


<210>  53
<211>  39
<212>  DNA
<213>  Homo Sapien

<400>  53
tgtgccagca gtttaggggg tgcctacgag cagtacttc                              39


<210>  54
<211>  13
<212>  PRT
<213>  Homo Sapien

<400>  54

Cys Ala Ser Ser Leu Gly Gly Ala Tyr Glu Gln Tyr Phe 
1               5                   10              


<210>  55
<211>  45
<212>  DNA
<213>  Homo Sapien

<400>  55
tgtgctgtga taactggtgg tactagctat ggaaagctga cattt                       45


<210>  56
<211>  15
<212>  PRT
<213>  Homo Sapien

<400>  56

Cys Ala Val Ile Thr Gly Gly Thr Ser Tyr Gly Lys Leu Thr Phe 
1               5                   10                  15  


<210>  57
<211>  48
<212>  DNA
<213>  Homo Sapien

<400>  57
tgtgctgtgc agaatgctgg tggtactagc tatggaaagc tgacattt                    48


<210>  58
<211>  16
<212>  PRT
<213>  Homo Sapien

<400>  58

Cys Ala Val Gln Asn Ala Gly Gly Thr Ser Tyr Gly Lys Leu Thr Phe 
1               5                   10                  15      


<210>  59
<211>  42
<212>  DNA
<213>  Homo Sapien

<400>  59
tgtgctgtgc ttacccaaac tggggcaaac aacctcttct tt                          42


<210>  60
<211>  14
<212>  PRT
<213>  Homo Sapien

<400>  60

Cys Ala Val Leu Thr Gln Thr Gly Ala Asn Asn Leu Phe Phe 
1               5                   10                  


<210>  61
<211>  54
<212>  DNA
<213>  Homo Sapien

<400>  61
tgtgctgtgc aggccttaag gaataatgct ggcaacaacc gtaagctgat ttgg             54


<210>  62
<211>  18
<212>  PRT
<213>  Homo Sapien

<400>  62

Cys Ala Val Gln Ala Leu Arg Asn Asn Ala Gly Asn Asn Arg Lys Leu 
1               5                   10                  15      


Ile Trp 
        


<210>  63
<211>  48
<212>  DNA
<213>  Homo Sapien

<400>  63
tgtgcctctt ctctgggctg gcgggaaacc tacaacgagc agttcttc                    48


<210>  64
<211>  16
<212>  PRT
<213>  Homo Sapien

<400>  64

Cys Ala Ser Ser Leu Gly Trp Arg Glu Thr Tyr Asn Glu Gln Phe Phe 
1               5                   10                  15      


<210>  65
<211>  12
<212>  DNA
<213>  Homo Sapien

<400>  65
agggccaaga ga                                                           12


<210>  66
<211>  4
<212>  PRT
<213>  Homo Sapien

<400>  66

Arg Ala Lys Arg 
1               


<210>  67
<211>  12
<212>  DNA
<213>  Homo Sapien

<400>  67
tctggatctg gc                                                           12


<210>  68
<211>  4
<212>  PRT
<213>  Homo Sapien

<400>  68

Ser Gly Ser Gly 
1               


<210>  69
<211>  72
<212>  DNA
<213>  Foot-and-mouth disease virus

<400>  69
gcccctgtga agcagaccct gaacttcgac ctgctgaagc tggccggcga cgtggaaagc       60

aaccctggcc cc                                                           72


<210>  70
<211>  24
<212>  PRT
<213>  Foot-and-mouth disease virus

<400>  70

Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly 
1               5                   10                  15      


Asp Val Glu Ser Asn Pro Gly Pro 
            20                  


<210>  71
<211>  804
<212>  DNA
<213>  Homo Sapien

<400>  71
atggacgggc cgcgcctgct gctgttgctg cttctggggg tgtcccttgg aggtgccaag       60

gaggcatgcc ccacaggcct gtacacacac agcggtgagt gctgcaaagc ctgcaacctg      120

ggcgagggtg tggcccagcc ttgtggagcc aaccagaccg tgtgtgagcc ctgcctggac      180

agcgtgacgt tctccgacgt ggtgagcgcg accgagccgt gcaagccgtg caccgagtgc      240

gtggggctcc agagcatgtc ggcgccatgc gtggaggccg acgacgccgt gtgccgctgc      300

gcctacggct actaccagga tgagacgact gggcgctgcg aggcgtgccg cgtgtgcgag      360

gcgggctcgg gcctcgtgtt ctcctgccag gacaagcaga acaccgtgtg cgaggagtgc      420

cccgacggca cgtattccga cgaggccaac cacgtggacc cgtgcctgcc ctgcaccgtg      480

tgcgaggaca ccgagcgcca gctccgcgag tgcacacgct gggccgacgc cgagtgcgag      540

gagatccctg gccgttggat tacacggtcc acacccccag agggctcgga cagcacagcc      600

cccagcaccc aggagcctga ggcacctcca gaacaagacc tcatagccag cacggtggca      660

ggtgtggtga ccacagtgat gggcagctcc cagcccgtgg tgacccgagg caccaccgac      720

aacctcatcc ctgtctattg ctccatcctg gctgctgtgg ttgtgggtct tgtggcctac      780

atagccttca agaggtggaa cagc                                             804


<210>  72
<211>  268
<212>  PRT
<213>  Homo Sapien

<400>  72

Met Asp Gly Pro Arg Leu Leu Leu Leu Leu Leu Leu Gly Val Ser Leu 
1               5                   10                  15      


Gly Gly Ala Lys Glu Ala Cys Pro Thr Gly Leu Tyr Thr His Ser Gly 
            20                  25                  30          


Glu Cys Cys Lys Ala Cys Asn Leu Gly Glu Gly Val Ala Gln Pro Cys 
        35                  40                  45              


Gly Ala Asn Gln Thr Val Cys Glu Pro Cys Leu Asp Ser Val Thr Phe 
    50                  55                  60                  


Ser Asp Val Val Ser Ala Thr Glu Pro Cys Lys Pro Cys Thr Glu Cys 
65                  70                  75                  80  


Val Gly Leu Gln Ser Met Ser Ala Pro Cys Val Glu Ala Asp Asp Ala 
                85                  90                  95      


Val Cys Arg Cys Ala Tyr Gly Tyr Tyr Gln Asp Glu Thr Thr Gly Arg 
            100                 105                 110         


Cys Glu Ala Cys Arg Val Cys Glu Ala Gly Ser Gly Leu Val Phe Ser 
        115                 120                 125             


Cys Gln Asp Lys Gln Asn Thr Val Cys Glu Glu Cys Pro Asp Gly Thr 
    130                 135                 140                 


Tyr Ser Asp Glu Ala Asn His Val Asp Pro Cys Leu Pro Cys Thr Val 
145                 150                 155                 160 


Cys Glu Asp Thr Glu Arg Gln Leu Arg Glu Cys Thr Arg Trp Ala Asp 
                165                 170                 175     


Ala Glu Cys Glu Glu Ile Pro Gly Arg Trp Ile Thr Arg Ser Thr Pro 
            180                 185                 190         


Pro Glu Gly Ser Asp Ser Thr Ala Pro Ser Thr Gln Glu Pro Glu Ala 
        195                 200                 205             


Pro Pro Glu Gln Asp Leu Ile Ala Ser Thr Val Ala Gly Val Val Thr 
    210                 215                 220                 


Thr Val Met Gly Ser Ser Gln Pro Val Val Thr Arg Gly Thr Thr Asp 
225                 230                 235                 240 


Asn Leu Ile Pro Val Tyr Cys Ser Ile Leu Ala Ala Val Val Val Gly 
                245                 250                 255     


Leu Val Ala Tyr Ile Ala Phe Lys Arg Trp Asn Ser 
            260                 265             


<210>  73
<211>  9
<212>  PRT
<213>  Homo Sapien

<400>  73

Ala Ala Gly Ile Gly Ile Leu Thr Val 
1               5                   


<210>  74
<211>  9
<212>  PRT
<213>  Homo Sapien

<400>  74

Cys Tyr Thr Trp Asn Gln Met Asn Leu 
1               5                   


<210>  75
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  75
atcccagtgt ggtggtacgg gaattctgcc atgggccccc agctccttgg c                51


<210>  76
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  76
atcgtcgacc actgtgctgg cggccgctcg agttccaggg ctgccttcag aaatcc           56


<210>  77
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  77
gaccactgtg ctggcggccg ctcgagctag cctctggaat cctttctctt gaccattgc        59


<210>  78
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  78
ggagagttcc ctctgtttgg agag                                              24


<210>  79
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  79
gtgtggtggt acgggaattc aagcagtggt atcaacgcag agt                         43


<210>  80
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  80
accactgtgc tggcggccgc tcagctggac cacagccgca gcg                         43


<210>  81
<211>  15
<212>  PRT
<213>  Homo Sapien

<400>  81

Cys Ala Ser Ser Leu Leu Gly Gly Ser Thr Asp Thr Gln Tyr Phe 
1               5                   10                  15  


<210>  82
<211>  15
<212>  PRT
<213>  Homo Sapien

<400>  82

Cys Ala Ser Ser Pro Ile Asp Gly Leu Asn Thr Glu Ala Phe Phe 
1               5                   10                  15  


<210>  83
<211>  11
<212>  PRT
<213>  Homo Sapien

<400>  83

Cys Ala Ser Ser Phe Asn Asp Glu Gln Phe Phe 
1               5                   10      


<210>  84
<211>  15
<212>  PRT
<213>  Homo Sapien

<400>  84

Cys Ala Ser Ser Pro Ser Gln Gly Gly Asn Thr Glu Ala Phe Phe 
1               5                   10                  15  


<210>  85
<211>  14
<212>  PRT
<213>  Homo Sapien

<400>  85

Cys Ala Ser Ser Asp Ser Thr Ala Ser Ser Glu Gln Phe Phe 
1               5                   10                  


<210>  86
<211>  14
<212>  PRT
<213>  Homo Sapien

<400>  86

Cys Ala Ser Ser Leu Ser Gly Ser Gly Asp Glu Gln Phe Phe 
1               5                   10                  


<210>  87
<211>  13
<212>  PRT
<213>  Homo Sapien

<400>  87

Cys Ala Ser Ser Leu Ser Phe Gly Thr Glu Ala Phe Phe 
1               5                   10              


<210>  88
<211>  13
<212>  PRT
<213>  Homo Sapien

<400>  88

Cys Ala Ser Ser Leu His Gly Pro Gly Gly Tyr Thr Phe 
1               5                   10              


<210>  89
<211>  11
<212>  PRT
<213>  Homo Sapien

<400>  89

Cys Ala Ser Gly Pro Ser Tyr Glu Gln Tyr Phe 
1               5                   10      


<210>  90
<211>  10
<212>  PRT
<213>  Homo Sapien

<400>  90

Cys Ala Ser Gly Ser Tyr Glu Gln Tyr Phe 
1               5                   10  


<210>  91
<211>  16
<212>  PRT
<213>  Homo Sapien

<400>  91

Cys Ala Ser Ser Val Phe Gly Gly Asp Met Gly Glu Lys Leu Phe Phe 
1               5                   10                  15      


<210>  92
<211>  14
<212>  PRT
<213>  Homo Sapien

<400>  92

Cys Ala Val Gln Ala Val Asp Ser Asn Tyr Gln Leu Ile Trp 
1               5                   10                  


<210>  93
<211>  933
<212>  DNA
<213>  Homo Sapien

<400>  93
atgggccccc agctccttgg ctatgtggtc ctttgccttc taggagcagg ccccctggaa       60

gcccaagtga cccagaaccc aagatacctc atcacagtga ctggaaagaa gttaacagtg      120

acttgttctc agaatatgaa ccatgagtat atgtcctggt atcgacaaga cccagggctg      180

ggcttaaggc agatctacta ttcaatgaat gttgaggtga ctgataaggg agatgttcct      240

gaagggtaca aagtctctcg aaaagagaag aggaatttcc ccctgatcct ggagtcgccc      300

agccccaacc agacctctct gtacttctgt gccagcagtc ccctgggggc catggagcag      360

tacttcgggc cgggcaccag gctcacggtc acagaggacc tgaaaaacgt gttcccaccc      420

gaggtcgctg tgtttgagcc atcagaagca gagatctccc acacccaaaa ggccacactg      480

gtgtgcctgg ccacaggctt ctaccccgac cacgtggagc tgagctggtg ggtgaatggg      540

aaggaggtgc acagtggggt cagcacagac ccgcagcccc tcaaggagca gcccgccctc      600

aatgactcca gatactgcct gagcagccgc ctgagggtct cggccacctt ctggcagaac      660

ccccgcaacc acttccgctg tcaagtccag ttctacgggc tctcggagaa tgacgagtgg      720

acccaggata gggccaaacc cgtcacccag atcgtcagcg ccgaggcctg gggtagagca      780

gactgtggct tcacctccga gtcttaccag caaggggtcc tgtctgccac catcctctat      840

gagatcttgc tagggaaggc caccttgtat gccgtgctgg tcagtgccct cgtgctgatg      900

gccatggtca agagaaagga ttccagaggc tag                                   933


<210>  94
<211>  311
<212>  PRT
<213>  Homo Sapien

<400>  94

Met Gly Pro Gln Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr 
            20                  25                  30          


Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln 
    50                  55                  60                  


Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro 
65                  70                  75                  80  


Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile 
                85                  90                  95      


Leu Glu Ser Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Pro Leu Gly Ala Met Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val 
    130                 135                 140                 


Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln 
            180                 185                 190         


Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser 
        195                 200                 205             


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His 
    210                 215                 220                 


Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp 
225                 230                 235                 240 


Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala 
                245                 250                 255     


Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly 
            260                 265                 270         


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
        275                 280                 285             


Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys 
    290                 295                 300                 


Arg Lys Asp Ser Arg Gly Glx 
305                 310     


<210>  95
<211>  930
<212>  DNA
<213>  Homo Sapien

<400>  95
atgggccccc agctccttgg ctatgtggtc ctttgccttc taggagcagg ccccctggaa       60

gcccaagtga cccagaaccc aagatacctc atcacagtga ctggaaagaa gttaacagtg      120

acttgttctc agaatatgaa ccatgagtat atgtcctggt atcgacaaga cccagggctg      180

ggcttaaggc agatctacta ttcaatgaat gttgaggtga ctgataaggg agatgttcct      240

gaagggtaca aagtctctcg aaaagagaag aggaatttcc ccctgatcct ggagtcgccc      300

agccccaacc agacctctct gtacttctgt gccagcagtc cctacatgat gaacactgaa      360

gctttctttg gacaaggcac cagactcaca gttgtagagg acctgaacaa ggtgttccca      420

cccgaggtcg ctgtgtttga gccatcagaa gcagagatct cccacaccca aaaggccaca      480

ctggtgtgcc tggccacagg cttcttccct gaccacgtgg agctgagctg gtgggtgaat      540

gggaaggagg tgcacagtgg ggtcagcacg gacccgcagc ccctcaagga gcagcccgcc      600

ctcaatgact ccagatactg cctgagcagc cgcctgaggg tctcggccac cttctggcag      660

aacccccgca accacttccg ctgtcaagtc cagttctacg ggctctcgga gaatgacgag      720

tggacccagg atagggccaa acccgtcacc cagatcgtca gcgccgaggc ctggggtaga      780

gcagactgtg gctttacctc ggtgtcctac cagcaagggg tcctgtctgc caccatcctc      840

tatgagatcc tgctagggaa ggccaccctg tatgctgtgc tggtcagcgc ccttgtgttg      900

atggccatgg tcaagagaaa ggatttctga                                       930


<210>  96
<211>  309
<212>  PRT
<213>  Homo Sapien

<400>  96

Met Gly Pro Gln Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr 
            20                  25                  30          


Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln 
    50                  55                  60                  


Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro 
65                  70                  75                  80  


Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile 
                85                  90                  95      


Leu Glu Ser Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Pro Tyr Met Met Asn Thr Glu Ala Phe Phe Gly Gln Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Val Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
        275                 280                 285             


Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val 
    290                 295                 300                 


Lys Arg Lys Asp Phe 
305                 


<210>  97
<211>  924
<212>  DNA
<213>  Homo Sapien

<400>  97
atgggctcca ggctgctctg ttgggtgctg ctttgtctcc tgggagcagg cccagtaaag       60

gctggagtca ctcaaactcc aagatatctg atcaaaacga gaggacagca agtgacactg      120

agctgctccc ctatctctgg gcataggagt gtatcctggt accaacagac cccaggacag      180

ggccttcagt tcctctttga atacttcagt gagacacaga gaaacaaagg aaacttccct      240

ggtcgattct cagggcgcca gttctctaac tctcgctctg agatgaatgt gagcaccttg      300

gagctggggg actcggccct ttatctttgc gccagcagct ggacagggga tggctacacc      360

ttcggttcgg ggaccaggtt aaccgttgta gaggacctga acaaggtgtt cccacccgag      420

gtcgctgtgt ttgagccatc agaagcagag atctcccaca cccaaaaggc cacactggtg      480

tgcctggcca caggcttctt ccctgaccac gtggagctga gctggtgggt gaatgggaag      540

gaggtgcaca gtggggtcag cacggacccg cagcccctca aggagcagcc cgccctcaat      600

gactccagat actgcctgag cagccgcctg agggtctcgg ccaccttctg gcagaacccc      660

cgcaaccact tccgctgtca agtccagttc tacgggctct cggagaatga cgagtggacc      720

caggataggg ccaaacccgt cacccagatc gtcagcgccg aggcctgggg tagagcagac      780

tgtggcttta cctcggtgtc ctaccagcaa ggggtcctgt ctgccaccat cctctatgag      840

atcctgctag ggaaggccac cctgtatgct gtgctggtca gcgcccttgt gttgatggcc      900

atggtcaaga gaaaggattt ctga                                             924


<210>  98
<211>  308
<212>  PRT
<213>  Homo Sapien

<400>  98

Met Gly Ser Arg Leu Leu Cys Trp Val Leu Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Val Lys Ala Gly Val Thr Gln Thr Pro Arg Tyr Leu Ile Lys 
            20                  25                  30          


Thr Arg Gly Gln Gln Val Thr Leu Ser Cys Ser Pro Ile Ser Gly His 
        35                  40                  45              


Arg Ser Val Ser Trp Tyr Gln Gln Thr Pro Gly Gln Gly Leu Gln Phe 
    50                  55                  60                  


Leu Phe Glu Tyr Phe Ser Glu Thr Gln Arg Asn Lys Gly Asn Phe Pro 
65                  70                  75                  80  


Gly Arg Phe Ser Gly Arg Gln Phe Ser Asn Ser Arg Ser Glu Met Asn 
                85                  90                  95      


Val Ser Thr Leu Glu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Trp Thr Gly Asp Gly Tyr Thr Phe Gly Ser Gly Thr Arg Leu Thr 
        115                 120                 125             


Val Val Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe 
    130                 135                 140                 


Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val 
145                 150                 155                 160 


Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp 
                165                 170                 175     


Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro 
            180                 185                 190         


Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser 
        195                 200                 205             


Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe 
    210                 215                 220                 


Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr 
225                 230                 235                 240 


Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp 
                245                 250                 255     


Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val 
            260                 265                 270         


Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu 
        275                 280                 285             


Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg 
    290                 295                 300                 


Lys Asp Phe Glx 
305             


<210>  99
<211>  15
<212>  DNA
<213>  Homo Sapien

<400>  99
atgaaccatg agtat                                                        15


<210>  100
<211>  5
<212>  PRT
<213>  Homo Sapien

<400>  100

Met Asn His Glu Tyr 
1               5   


<210>  101
<211>  15
<212>  DNA
<213>  Homo Sapien

<400>  101
atgaaccatg agtat                                                        15


<210>  102
<211>  5
<212>  PRT
<213>  Homo Sapien

<400>  102

Met Asn His Glu Tyr 
1               5   


<210>  103
<211>  15
<212>  DNA
<213>  Homo Sapien

<400>  103
tctgggcata ggagt                                                        15


<210>  104
<211>  5
<212>  PRT
<213>  Homo Sapien

<400>  104

Ser Gly His Arg Ser 
1               5   


<210>  105
<211>  18
<212>  DNA
<213>  Homo Sapien

<400>  105
tcaatgaatg ttgaggtg                                                     18


<210>  106
<211>  6
<212>  PRT
<213>  Homo Sapien

<400>  106

Ser Met Asn Val Glu Val 
1               5       


<210>  107
<211>  18
<212>  DNA
<213>  Homo Sapien

<400>  107
tcaatgaatg ttgaggtg                                                     18


<210>  108
<211>  6
<212>  PRT
<213>  Homo Sapien

<400>  108

Ser Met Asn Val Glu Val 
1               5       


<210>  109
<211>  18
<212>  DNA
<213>  Homo Sapien

<400>  109
tacttcagtg agacacag                                                     18


<210>  110
<211>  6
<212>  PRT
<213>  Homo Sapien

<400>  110

Tyr Phe Ser Glu Thr Gln 
1               5       


<210>  111
<211>  39
<212>  DNA
<213>  Homo Sapien

<400>  111
tgtgccagca gtcccctggg ggccatggag cagtacttc                              39


<210>  112
<211>  13
<212>  PRT
<213>  Homo Sapien

<400>  112

Cys Ala Ser Ser Pro Leu Gly Ala Met Glu Gln Tyr Phe 
1               5                   10              


<210>  113
<211>  42
<212>  DNA
<213>  Homo Sapien

<400>  113
tgtgccagca gtccctacat gatgaacact gaagctttct tt                          42


<210>  114
<211>  14
<212>  PRT
<213>  Homo Sapien

<400>  114

Cys Ala Ser Ser Pro Tyr Met Met Asn Thr Glu Ala Phe Phe 
1               5                   10                  


<210>  115
<211>  36
<212>  DNA
<213>  Homo Sapien

<400>  115
tgcgccagca gctggacagg ggatggctac accttc                                 36


<210>  116
<211>  12
<212>  PRT
<213>  Homo Sapien

<400>  116

Cys Ala Ser Ser Trp Thr Gly Asp Gly Tyr Thr Phe 
1               5                   10          


<210>  117
<211>  12
<212>  PRT
<213>  Homo Sapien

<400>  117

Cys Ala Ser Ser His Gly Gly Asn Glu Gln Tyr Phe 
1               5                   10          


<210>  118
<211>  13
<212>  PRT
<213>  Homo Sapien

<400>  118

Cys Ala Ser Ser Arg Asp Phe Gly Asn Thr Ile Tyr Phe 
1               5                   10              


<210>  119
<211>  14
<212>  PRT
<213>  Homo Sapien

<400>  119

Cys Ala Ser Ser Leu Ala Met Gly Ala Thr Glu Ala Phe Phe 
1               5                   10                  


<210>  120
<211>  11
<212>  PRT
<213>  Homo Sapien

<400>  120

Cys Ala Thr Gly Val Thr Asp Thr Gln Tyr Phe 
1               5                   10      


<210>  121
<211>  11
<212>  PRT
<213>  Homo Sapien

<400>  121

Cys Ala Ser Ser Glu Val Ala Trp Gln Phe Phe 
1               5                   10      


<210>  122
<211>  11
<212>  PRT
<213>  Homo Sapien

<400>  122

Cys Ala Ser Asp Glu Gly Phe Gly Tyr Thr Phe 
1               5                   10      


<210>  123
<211>  4
<212>  PRT
<213>  Homo Sapien


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa can be any naturally occuring amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa can be Lys or Arg

<400>  123

Arg Xaa Xaa Arg 
1               


<210>  124
<211>  4
<212>  PRT
<213>  Homo Sapien

<400>  124

Gly Gly Ser Gly 
1               


