                               SEQUENCE LISTING

<110> IAFRATE, ANTHONY JOHN
      LE, LONG PHI
      ZHENG, ZONGLI
 
<120> METHODS FOR DETERMINING A NUCLEOTIDE SEQUENCE

<130> 030258-079362-PCT

<140> PCT/US15/12841
<141> 2015-01-26

<150> 61/931,943
<151> 2014-01-27

<160> 12    

<170> PatentIn version 3.5

<210> 1
<211> 6267
<212> DNA
<213> Homo sapiens

<400> 1
agctgcaagt ggcgggcgcc caggcagatg cgatccagcg gctctggggg cggcagcggt       60

ggtagcagct ggtacctccc gccgcctctg ttcggagggt cgcggggcac cgaggtgctt      120

tccggccgcc ctctggtcgg ccacccaaag ccgcgggcgc tgatgatggg tgaggagggg      180

gcggcaagat ttcgggcgcc cctgccctga acgccctcag ctgctgccgc cggggccgct      240

ccagtgcctg cgaactctga ggagccgagg cgccggtgag agcaaggacg ctgcaaactt      300

gcgcagcgcg ggggctggga ttcacgccca gaagttcagc aggcagacag tccgaagcct      360

tcccgcagcg gagagatagc ttgagggtgc gcaagacggc agcctccgcc ctcggttccc      420

gcccagaccg ggcagaagag cttggaggag ccaaaaggaa cgcaaaaggc ggccaggaca      480

gcgtgcagca gctgggagcc gccgttctca gccttaaaag ttgcagagat tggaggctgc      540

cccgagaggg gacagacccc agctccgact gcggggggca ggagaggacg gtacccaact      600

gccacctccc ttcaaccata gtagttcctc tgtaccgagc gcagcgagct acagacgggg      660

gcgcggcact cggcgcggag agcgggaggc tcaaggtccc agccagtgag cccagtgtgc      720

ttgagtgtct ctggactcgc ccctgagctt ccaggtctgt ttcatttaga ctcctgctcg      780

cctccgtgca gttgggggaa agcaagagac ttgcgcgcac gcacagtcct ctggagatca      840

ggtggaagga gccgctgggt accaaggact gttcagagcc tcttcccatc tcggggagag      900

cgaagggtga ggctgggccc ggagagcagt gtaaacggcc tcctccggcg ggatgggagc      960

catcgggctc ctgtggctcc tgccgctgct gctttccacg gcagctgtgg gctccgggat     1020

ggggaccggc cagcgcgcgg gctccccagc tgcggggccg ccgctgcagc cccgggagcc     1080

actcagctac tcgcgcctgc agaggaagag tctggcagtt gacttcgtgg tgccctcgct     1140

cttccgtgtc tacgcccggg acctactgct gccaccatcc tcctcggagc tgaaggctgg     1200

caggcccgag gcccgcggct cgctagctct ggactgcgcc ccgctgctca ggttgctggg     1260

gccggcgccg ggggtctcct ggaccgccgg ttcaccagcc ccggcagagg cccggacgct     1320

gtccagggtg ctgaagggcg gctccgtgcg caagctccgg cgtgccaagc agttggtgct     1380

ggagctgggc gaggaggcga tcttggaggg ttgcgtcggg ccccccgggg aggcggctgt     1440

ggggctgctc cagttcaatc tcagcgagct gttcagttgg tggattcgcc aaggcgaagg     1500

gcgactgagg atccgcctga tgcccgagaa gaaggcgtcg gaagtgggca gagagggaag     1560

gctgtccgcg gcaattcgcg cctcccagcc ccgccttctc ttccagatct tcgggactgg     1620

tcatagctcc ttggaatcac caacaaacat gccttctcct tctcctgatt attttacatg     1680

gaatctcacc tggataatga aagactcctt ccctttcctg tctcatcgca gccgatatgg     1740

tctggagtgc agctttgact tcccctgtga gctggagtat tcccctccac tgcatgacct     1800

caggaaccag agctggtcct ggcgccgcat cccctccgag gaggcctccc agatggactt     1860

gctggatggg cctggggcag agcgttctaa ggagatgccc agaggctcct ttctccttct     1920

caacacctca gctgactcca agcacaccat cctgagtccg tggatgagga gcagcagtga     1980

gcactgcaca ctggccgtct cggtgcacag gcacctgcag ccctctggaa ggtacattgc     2040

ccagctgctg ccccacaacg aggctgcaag agagatcctc ctgatgccca ctccagggaa     2100

gcatggttgg acagtgctcc agggaagaat cgggcgtcca gacaacccat ttcgagtggc     2160

cctggaatac atctccagtg gaaaccgcag cttgtctgca gtggacttct ttgccctgaa     2220

gaactgcagt gaaggaacat ccccaggctc caagatggcc ctgcagagct ccttcacttg     2280

ttggaatggg acagtcctcc agcttgggca ggcctgtgac ttccaccagg actgtgccca     2340

gggagaagat gagagccaga tgtgccggaa actgcctgtg ggtttttact gcaactttga     2400

agatggcttc tgtggctgga cccaaggcac actgtcaccc cacactcctc aatggcaggt     2460

caggacccta aaggatgccc ggttccagga ccaccaagac catgctctat tgctcagtac     2520

cactgatgtc cccgcttctg aaagtgctac agtgaccagt gctacgtttc ctgcaccgat     2580

caagagctct ccatgtgagc tccgaatgtc ctggctcatt cgtggagtct tgaggggaaa     2640

cgtgtccttg gtgctagtgg agaacaaaac cgggaaggag caaggcagga tggtctggca     2700

tgtcgccgcc tatgaaggct tgagcctgtg gcagtggatg gtgttgcctc tcctcgatgt     2760

gtctgacagg ttctggctgc agatggtcgc atggtgggga caaggatcca gagccatcgt     2820

ggcttttgac aatatctcca tcagcctgga ctgctacctc accattagcg gagaggacaa     2880

gatcctgcag aatacagcac ccaaatcaag aaacctgttt gagagaaacc caaacaagga     2940

gctgaaaccc ggggaaaatt caccaagaca gacccccatc tttgacccta cagttcattg     3000

gctgttcacc acatgtgggg ccagcgggcc ccatggcccc acccaggcac agtgcaacaa     3060

cgcctaccag aactccaacc tgagcgtgga ggtggggagc gagggccccc tgaaaggcat     3120

ccagatctgg aaggtgccag ccaccgacac ctacagcatc tcgggctacg gagctgctgg     3180

cgggaaaggc gggaagaaca ccatgatgcg gtcccacggc gtgtctgtgc tgggcatctt     3240

caacctggag aaggatgaca tgctgtacat cctggttggg cagcagggag aggacgcctg     3300

ccccagtaca aaccagttaa tccagaaagt ctgcattgga gagaacaatg tgatagaaga     3360

agaaatccgt gtgaacagaa gcgtgcatga gtgggcagga ggcggaggag gagggggtgg     3420

agccacctac gtatttaaga tgaaggatgg agtgccggtg cccctgatca ttgcagccgg     3480

aggtggtggc agggcctacg gggccaagac agacacgttc cacccagaga gactggagaa     3540

taactcctcg gttctagggc taaacggcaa ttccggagcc gcaggtggtg gaggtggctg     3600

gaatgataac acttccttgc tctgggccgg aaaatctttg caggagggtg ccaccggagg     3660

acattcctgc ccccaggcca tgaagaagtg ggggtgggag acaagagggg gtttcggagg     3720

gggtggaggg gggtgctcct caggtggagg aggcggagga tatataggcg gcaatgcagc     3780

ctcaaacaat gaccccgaaa tggatgggga agatggggtt tccttcatca gtccactggg     3840

catcctgtac accccagctt taaaagtgat ggaaggccac ggggaagtga atattaagca     3900

ttatctaaac tgcagtcact gtgaggtaga cgaatgtcac atggaccctg aaagccacaa     3960

ggtcatctgc ttctgtgacc acgggacggt gctggctgag gatggcgtct cctgcattgt     4020

gtcacccacc ccggagccac acctgccact ctcgctgatc ctctctgtgg tgacctctgc     4080

cctcgtggcc gccctggtcc tggctttctc cggcatcatg attgtgtacc gccggaagca     4140

ccaggagctg caagccatgc agatggagct gcagagccct gagtacaagc tgagcaagct     4200

ccgcacctcg accatcatga ccgactacaa ccccaactac tgctttgctg gcaagacctc     4260

ctccatcagt gacctgaagg aggtgccgcg gaaaaacatc accctcattc ggggtctggg     4320

ccatggcgcc tttggggagg tgtatgaagg ccaggtgtcc ggaatgccca acgacccaag     4380

ccccctgcaa gtggctgtga agacgctgcc tgaagtgtgc tctgaacagg acgaactgga     4440

tttcctcatg gaagccctga tcatcagcaa attcaaccac cagaacattg ttcgctgcat     4500

tggggtgagc ctgcaatccc tgccccggtt catcctgctg gagctcatgg cggggggaga     4560

cctcaagtcc ttcctccgag agacccgccc tcgcccgagc cagccctcct ccctggccat     4620

gctggacctt ctgcacgtgg ctcgggacat tgcctgtggc tgtcagtatt tggaggaaaa     4680

ccacttcatc caccgagaca ttgctgccag aaactgcctc ttgacctgtc caggccctgg     4740

aagagtggcc aagattggag acttcgggat ggcccgagac atctacaggg cgagctacta     4800

tagaaaggga ggctgtgcca tgctgccagt taagtggatg cccccagagg ccttcatgga     4860

aggaatattc acttctaaaa cagacacatg gtcctttgga gtgctgctat gggaaatctt     4920

ttctcttgga tatatgccat accccagcaa aagcaaccag gaagttctgg agtttgtcac     4980

cagtggaggc cggatggacc cacccaagaa ctgccctggg cctgtatacc ggataatgac     5040

tcagtgctgg caacatcagc ctgaagacag gcccaacttt gccatcattt tggagaggat     5100

tgaatactgc acccaggacc cggatgtaat caacaccgct ttgccgatag aatatggtcc     5160

acttgtggaa gaggaagaga aagtgcctgt gaggcccaag gaccctgagg gggttcctcc     5220

tctcctggtc tctcaacagg caaaacggga ggaggagcgc agcccagctg ccccaccacc     5280

tctgcctacc acctcctctg gcaaggctgc aaagaaaccc acagctgcag agatctctgt     5340

tcgagtccct agagggccgg ccgtggaagg gggacacgtg aatatggcat tctctcagtc     5400

caaccctcct tcggagttgc acaaggtcca cggatccaga aacaagccca ccagcttgtg     5460

gaacccaacg tacggctcct ggtttacaga gaaacccacc aaaaagaata atcctatagc     5520

aaagaaggag ccacacgaca ggggtaacct ggggctggag ggaagctgta ctgtcccacc     5580

taacgttgca actgggagac ttccgggggc ctcactgctc ctagagccct cttcgctgac     5640

tgccaatatg aaggaggtac ctctgttcag gctacgtcac ttcccttgtg ggaatgtcaa     5700

ttacggctac cagcaacagg gcttgccctt agaagccgct actgcccctg gagctggtca     5760

ttacgaggat accattctga aaagcaagaa tagcatgaac cagcctgggc cctgagctcg     5820

gtcgcacact cacttctctt ccttgggatc cctaagaccg tggaggagag agaggcaatg     5880

gctccttcac aaaccagaga ccaaatgtca cgttttgttt tgtgccaacc tattttgaag     5940

taccaccaaa aaagctgtat tttgaaaatg ctttagaaag gttttgagca tgggttcatc     6000

ctattctttc gaaagaagaa aatatcataa aaatgagtga taaatacaag gcccagatgt     6060

ggttgcataa ggtttttatg catgtttgtt gtatacttcc ttatgcttct ttcaaattgt     6120

gtgtgctctg cttcaatgta gtcagaatta gctgcttcta tgtttcatag ttggggtcat     6180

agatgtttcc ttgccttgtt gatgtggaca tgagccattt gaggggagag ggaacggaaa     6240

taaaggagtt atttgtaatg actaaaa                                         6267


<210> 2
<211> 7368
<212> DNA
<213> Homo sapiens

<400> 2
caagctttca agcattcaaa ggtctaaatg aaaaaggcta agtattattt caaaaggcaa       60

gtatatccta atatagcaaa acaaacaaag caaaatccat cagctactcc tccaattgaa      120

gtgatgaagc ccaaataatt catatagcaa aatggagaaa attagaccgg ccatctaaaa      180

atctgccatt ggtgaagtga tgaagaacat ttactgtctt attccgaagc ttgtcaattt      240

tgcaactctt ggctgcctat ggatttctgt ggtgcagtgt acagttttaa atagctgcct      300

aaagtcgtgt gtaactaatc tgggccagca gcttgacctt ggcacaccac ataatctgag      360

tgaaccgtgt atccaaggat gtcacttttg gaactctgta gatcagaaaa actgtgcttt      420

aaagtgtcgg gagtcgtgtg aggttggctg tagcagcgcg gaaggtgcat atgaagagga      480

agtactggaa aatgcagacc taccaactgc tccctttgct tcttccattg gaagccacaa      540

tatgacatta cgatggaaat ctgcaaactt ctctggagta aaatacatca ttcagtggaa      600

atatgcacaa cttctgggaa gctggactta tactaagact gtgtccagac cgtcctatgt      660

ggtcaagccc ctgcacccct tcactgagta cattttccga gtggtttgga tcttcacagc      720

gcagctgcag ctctactccc ctccaagtcc cagttacagg actcatcctc atggagttcc      780

tgaaactgca cctttgatta ggaatattga gagctcaagt cccgacactg tggaagtcag      840

ctgggatcca cctcaattcc caggtggacc tattttgggt tataacttaa ggctgatcag      900

caaaaatcaa aaattagatg cagggacaca gagaaccagt ttccagtttt actccacttt      960

accaaatact atctacaggt tttctattgc agcagtaaat gaagttggtg agggtccaga     1020

agcagaatct agtattacca cttcatcttc agcagttcaa caagaggaac agtggctctt     1080

tttatccaga aaaacttctc taagaaagag atctttaaaa catttagtag atgaagcaca     1140

ttgccttcgg ttggatgcta tataccataa tattacagga atatctgttg atgtccacca     1200

gcaaattgtt tatttctctg aaggaactct catatgggcg aagaaggctg ccaacatgtc     1260

tgatgtatct gacctgagaa ttttttacag aggttcagga ttaatttctt ctatctccat     1320

agattggctt tatcaaagaa tgtatttcat catggatgaa ctggtatgtg tctgtgattt     1380

agagaactgc tcaaacatcg aggaaattac tccaccctct attagtgcac ctcaaaaaat     1440

tgtggctgat tcatacaatg ggtatgtctt ttacctcctg agagatggca tttatagagc     1500

agaccttcct gtaccatctg gccggtgtgc agaagctgtg cgtattgtgg agagttgcac     1560

gttaaaggac tttgcaatca agccacaagc caagcgaatc atttacttca atgacactgc     1620

ccaagtcttc atgtcaacat ttctggatgg ctctgcttcc catctcatcc tacctcgcat     1680

cccctttgct gatgtgaaaa gttttgcttg tgaaaacaat gactttcttg tcacagatgg     1740

caaggtcatt ttccaacagg atgctttgtc ttttaatgaa ttcatcgtgg gatgtgacct     1800

gagtcacata gaagaatttg ggtttggtaa cttggtcatc tttggctcat cctcccagct     1860

gcaccctctg ccaggccgcc cgcaggagct ttcggtgctg tttggctctc accaggctct     1920

tgttcaatgg aagcctcctg cccttgccat aggagccaat gtcatcctga tcagtgatat     1980

tattgaactc tttgaattag gcccttctgc ctggcagaac tggacctatg aggtgaaagt     2040

atccacccaa gaccctcctg aagtcactca tattttcttg aacataagtg gaaccatgct     2100

gaatgtacct gagctgcaga gtgctatgaa atacaaggtt tctgtgagag caagttctcc     2160

aaagaggcca ggcccctggt cagagccctc agtgggtact accctggtgc cagctagtga     2220

accaccattt atcatggctg tgaaagaaga tgggctttgg agtaaaccat taaatagctt     2280

tggcccagga gagttcttat cctctgatat aggaaatgtg tcagacatgg attggtataa     2340

caacagcctc tactacagtg acacgaaagg cgacgttttt gtgtggctgc tgaatgggac     2400

ggatatctca gagaattatc acctacccag cattgcagga gcaggggctt tagcttttga     2460

gtggctgggt cactttctct actgggctgg aaagacatat gtgatacaaa ggcagtctgt     2520

gttgacggga cacacagaca ttgttaccca cgtgaagcta ttggtgaatg acatggtggt     2580

ggattcagtt ggtggatatc tctactggac cacactctat tcagtggaaa gcaccagact     2640

aaatggggaa agttcccttg tactacagac acagccttgg ttttctggga aaaaggtaat     2700

tgctctaact ttagacctca gtgatgggct cctgtattgg ttggttcaag acagtcaatg     2760

tattcacctg tacacagctg ttcttcgggg acagagcact ggggatacca ccatcacaga     2820

atttgcagcc tggagtactt ctgaaatttc ccagaatgca ctgatgtact atagtggtcg     2880

gctgttctgg atcaatggct ttaggattat cacaactcaa gaaataggtc agaaaaccag     2940

tgtctctgtt ttggaaccag ccagatttaa tcagttcaca attattcaga catcccttaa     3000

gcccctgcca gggaactttt cctttacccc taaggttatt ccagattctg ttcaagagtc     3060

ttcatttagg attgaaggaa atgcttcaag ttttcaaatc ctgtggaatg gtccccctgc     3120

ggtagactgg ggtgtagttt tctacagtgt agaatttagt gctcattcta agttcttggc     3180

tagtgaacaa cactctttac ctgtatttac tgtggaagga ctggaacctt atgccttatt     3240

taatctttct gtcactcctt atacctactg gggaaagggc cccaaaacat ctctgtcact     3300

tcgagcacct gaaacagttc catcagcacc agagaacccc agaatattta tattaccaag     3360

tggaaaatgc tgcaacaaga atgaagttgt ggtggaattt aggtggaaca aacctaagca     3420

tgaaaatggg gtgttaacaa aatttgaaat tttctacaat atatccaatc aaagtattac     3480

aaacaaaaca tgtgaagact ggattgctgt caatgtcact ccctcagtga tgtcttttca     3540

acttgaaggc atgagtccca gatgctttat tgccttccag gttagggcct ttacatctaa     3600

ggggccagga ccatatgctg acgttgtaaa gtctacaaca tcagaaatca acccatttcc     3660

tcacctcata actcttcttg gtaacaagat agttttttta gatatggatc aaaatcaagt     3720

tgtgtggacg ttttcagcag aaagagttat cagtgccgtt tgctacacag ctgataatga     3780

gatgggatat tatgctgaag gggactcact ctttcttctg cacttgcaca atcgctctag     3840

ctctgagctt ttccaagatt cactggtttt tgatatcaca gttattacaa ttgactggat     3900

ttcaaggcac ctctactttg cactgaaaga atcacaaaat ggaatgcaag tatttgatgt     3960

tgatcttgaa cacaaggtga aatatcccag agaggtgaag attcacaata ggaattcaac     4020

aataatttct ttttctgtat atcctctttt aagtcgcttg tattggacag aagtttccaa     4080

ttttggctac cagatgttct actacagtat tatcagtcac accttgcacc gaattctgca     4140

acccacagct acaaaccaac aaaacaaaag gaatcaatgt tcttgtaatg tgactgaatt     4200

tgagttaagt ggagcaatgg ctattgatac ctctaaccta gagaaaccat tgatatactt     4260

tgccaaagca caagagatct gggcaatgga tctggaaggc tgtcagtgtt ggagagttat     4320

cacagtacct gctatgctcg caggaaaaac ccttgttagc ttaactgtgg atggagatct     4380

tatatactgg atcatcacag caaaggacag cacacagatt tatcaggcaa agaaaggaaa     4440

tggggccatc gtttcccagg tgaaggccct aaggagtagg catatcttgg cttacagttc     4500

agttatgcag ccttttccag ataaagcgtt tctgtctcta gcttcagaca ctgtggaacc     4560

aactatactt aatgccacta acactagcct cacaatcaga ttacctctgg ccaagacaaa     4620

cctcacatgg tatggcatca ccagccctac tccaacatac ctggtttatt atgcagaagt     4680

taatgacagg aaaaacagct ctgacttgaa atatagaatt ctggaatttc aggacagtat     4740

agctcttatt gaagatttac aaccattttc aacatacatg atacagatag ctgtaaaaaa     4800

ttattattca gatcctttgg aacatttacc accaggaaaa gagatttggg gaaaaactaa     4860

aaatggagta ccagaggcag tgcagctcat taatacaact gtgcggtcag acaccagcct     4920

cattatatct tggagagaat ctcacaagcc aaatggacct aaagaatcag tccgttatca     4980

gttggcaatc tcacacctgg ccctaattcc tgaaactcct ctaagacaaa gtgaatttcc     5040

aaatggaagg ctcactctcc ttgttactag actgtctggt ggaaatattt atgtgttaaa     5100

ggttcttgcc tgccactctg aggaaatgtg gtgtacagag agtcatcctg tcactgtgga     5160

aatgtttaac acaccagaga aaccttattc cttggttcca gagaacacta gtttgcaatt     5220

taattggaag gctccattga atgttaacct catcagattt tgggttgagc tacagaagtg     5280

gaaatacaat gagttttacc atgttaaaac ttcatgcagc caaggtcctg cttatgtctg     5340

taatatcaca aatctacaac cttatacttc atataatgtc agagtagtgg tggtttataa     5400

gacgggagaa aatagcacct cacttccaga aagctttaag acaaaagctg gagtcccaaa     5460

taaaccaggc attcccaaat tactagaagg gagtaaaaat tcaatacagt gggagaaagc     5520

tgaagataat ggatgtagaa ttacatacta tatccttgag ataagaaaga gcacttcaaa     5580

taatttacag aaccagaatt taaggtggaa gatgacattt aatggatcct gcagtagtgt     5640

ttgcacatgg aagtccaaaa acctgaaagg aatatttcag ttcagagtag tagctgcaaa     5700

taatctaggg tttggtgaat atagtggaat cagtgagaat attatattag ttggagatga     5760

tttttggata ccagaaacaa gtttcatact tactattata gttggaatat ttctggttgt     5820

tacaatccca ctgacctttg tctggcatag aagattaaag aatcaaaaaa gtgccaagga     5880

aggggtgaca gtgcttataa acgaagacaa agagttggct gagctgcgag gtctggcagc     5940

cggagtaggc ctggctaatg cctgctatgc aatacatact cttccaaccc aagaggagat     6000

tgaaaatctt cctgccttcc ctcgggaaaa actgactctg cgtctcttgc tgggaagtgg     6060

agcctttgga gaagtgtatg aaggaacagc agtggacatc ttaggagttg gaagtggaga     6120

aatcaaagta gcagtgaaga ctttgaagaa gggttccaca gaccaggaga agattgaatt     6180

cctgaaggag gcacatctga tgagcaaatt taatcatccc aacattctga agcagcttgg     6240

agtttgtctg ctgaatgaac cccaatacat tatcctggaa ctgatggagg gaggagacct     6300

tcttacttat ttgcgtaaag cccggatggc aacgttttat ggtcctttac tcaccttggt     6360

tgaccttgta gacctgtgtg tagatatttc aaaaggctgt gtctacttgg aacggatgca     6420

tttcattcac agggatctgg cagctagaaa ttgccttgtt tccgtgaaag actataccag     6480

tccacggata gtgaagattg gagactttgg actcgccaga gacatctata aaaatgatta     6540

ctatagaaag agaggggaag gcctgctccc agttcggtgg atggctccag aaagtttgat     6600

ggatggaatc ttcactactc aatctgatgt atggtctttt ggaattctga tttgggagat     6660

tttaactctt ggtcatcagc cttatccagc tcattccaac cttgatgtgt taaactatgt     6720

gcaaacagga gggagactgg agccaccaag aaattgtcct gatgatctgt ggaatttaat     6780

gacccagtgc tgggctcaag aacccgacca aagacctact tttcatagaa ttcaggacca     6840

acttcagtta ttcagaaatt ttttcttaaa tagcatttat aagtccagag atgaagcaaa     6900

caacagtgga gtcataaatg aaagctttga aggtgaagat ggcgatgtga tttgtttgaa     6960

ttcagatgac attatgccag ttgctttaat ggaaacgaag aaccgagaag ggttaaacta     7020

tatggtactt gctacagaat gtggccaagg tgaagaaaag tctgagggtc ctctaggctc     7080

ccaggaatct gaatcttgtg gtctgaggaa agaagagaag gaaccacatg cagacaaaga     7140

tttctgccaa gaaaaacaag tggcttactg cccttctggc aagcctgaag gcctgaacta     7200

tgcctgtctc actcacagtg gatatggaga tgggtctgat taatagcgtt gtttgggaaa     7260

tagagagttg agataaacac tctcattcag tagttactga aagaaaactc tgctagaatg     7320

ataaatgtca tggtggtcta taactccaaa taaacaatgc aacgttcc                  7368


<210> 3
<211> 4174
<212> DNA
<213> Homo sapiens

<400> 3
agtcccgcga ccgaagcagg gcgcgcagca gcgctgagtg ccccggaacg tgcgtcgcgc       60

ccccagtgtc cgtcgcgtcc gccgcgcccc gggcggggat ggggcggcca gactgagcgc      120

cgcacccgcc atccagaccc gccggcccta gccgcagtcc ctccagccgt ggccccagcg      180

cgcacgggcg atggcgaagg cgacgtccgg tgccgcgggg ctgcgtctgc tgttgctgct      240

gctgctgccg ctgctaggca aagtggcatt gggcctctac ttctcgaggg atgcttactg      300

ggagaagctg tatgtggacc aggcggccgg cacgcccttg ctgtacgtcc atgccctgcg      360

ggacgcccct gaggaggtgc ccagcttccg cctgggccag catctctacg gcacgtaccg      420

cacacggctg catgagaaca actggatctg catccaggag gacaccggcc tcctctacct      480

taaccggagc ctggaccata gctcctggga gaagctcagt gtccgcaacc gcggctttcc      540

cctgctcacc gtctacctca aggtcttcct gtcacccaca tcccttcgtg agggcgagtg      600

ccagtggcca ggctgtgccc gcgtatactt ctccttcttc aacacctcct ttccagcctg      660

cagctccctc aagccccggg agctctgctt cccagagaca aggccctcct tccgcattcg      720

ggagaaccga cccccaggca ccttccacca gttccgcctg ctgcctgtgc agttcttgtg      780

ccccaacatc agcgtggcct acaggctcct ggagggtgag ggtctgccct tccgctgcgc      840

cccggacagc ctggaggtga gcacgcgctg ggccctggac cgcgagcagc gggagaagta      900

cgagctggtg gccgtgtgca ccgtgcacgc cggcgcgcgc gaggaggtgg tgatggtgcc      960

cttcccggtg accgtgtacg acgaggacga ctcggcgccc accttccccg cgggcgtcga     1020

caccgccagc gccgtggtgg agttcaagcg gaaggaggac accgtggtgg ccacgctgcg     1080

tgtcttcgat gcagacgtgg tacctgcatc aggggagctg gtgaggcggt acacaagcac     1140

gctgctcccc ggggacacct gggcccagca gaccttccgg gtggaacact ggcccaacga     1200

gacctcggtc caggccaacg gcagcttcgt gcgggcgacc gtacatgact ataggctggt     1260

tctcaaccgg aacctctcca tctcggagaa ccgcaccatg cagctggcgg tgctggtcaa     1320

tgactcagac ttccagggcc caggagcggg cgtcctcttg ctccacttca acgtgtcggt     1380

gctgccggtc agcctgcacc tgcccagtac ctactccctc tccgtgagca ggagggctcg     1440

ccgatttgcc cagatcggga aagtctgtgt ggaaaactgc caggcattca gtggcatcaa     1500

cgtccagtac aagctgcatt cctctggtgc caactgcagc acgctagggg tggtcacctc     1560

agccgaggac acctcgggga tcctgtttgt gaatgacacc aaggccctgc ggcggcccaa     1620

gtgtgccgaa cttcactaca tggtggtggc caccgaccag cagacctcta ggcaggccca     1680

ggcccagctg cttgtaacag tggaggggtc atatgtggcc gaggaggcgg gctgccccct     1740

gtcctgtgca gtcagcaaga gacggctgga gtgtgaggag tgtggcggcc tgggctcccc     1800

aacaggcagg tgtgagtgga ggcaaggaga tggcaaaggg atcaccagga acttctccac     1860

ctgctctccc agcaccaaga cctgccccga cggccactgc gatgttgtgg agacccaaga     1920

catcaacatt tgccctcagg actgcctccg gggcagcatt gttgggggac acgagcctgg     1980

ggagccccgg gggattaaag ctggctatgg cacctgcaac tgcttccctg aggaggagaa     2040

gtgcttctgc gagcccgaag acatccagga tccactgtgc gacgagctgt gccgcacggt     2100

gatcgcagcc gctgtcctct tctccttcat cgtctcggtg ctgctgtctg ccttctgcat     2160

ccactgctac cacaagtttg cccacaagcc acccatctcc tcagctgaga tgaccttccg     2220

gaggcccgcc caggccttcc cggtcagcta ctcctcttcc ggtgcccgcc ggccctcgct     2280

ggactccatg gagaaccagg tctccgtgga tgccttcaag atcctggagg atccaaagtg     2340

ggaattccct cggaagaact tggttcttgg aaaaactcta ggagaaggcg aatttggaaa     2400

agtggtcaag gcaacggcct tccatctgaa aggcagagca gggtacacca cggtggccgt     2460

gaagatgctg aaagagaacg cctccccgag tgagcttcga gacctgctgt cagagttcaa     2520

cgtcctgaag caggtcaacc acccacatgt catcaaattg tatggggcct gcagccagga     2580

tggcccgctc ctcctcatcg tggagtacgc caaatacggc tccctgcggg gcttcctccg     2640

cgagagccgc aaagtggggc ctggctacct gggcagtgga ggcagccgca actccagctc     2700

cctggaccac ccggatgagc gggccctcac catgggcgac ctcatctcat ttgcctggca     2760

gatctcacag gggatgcagt atctggccga gatgaagctc gttcatcggg acttggcagc     2820

cagaaacatc ctggtagctg aggggcggaa gatgaagatt tcggatttcg gcttgtcccg     2880

agatgtttat gaagaggatt cctacgtgaa gaggagccag ggtcggattc cagttaaatg     2940

gatggcaatt gaatcccttt ttgatcatat ctacaccacg caaagtgatg tatggtcttt     3000

tggtgtcctg ctgtgggaga tcgtgaccct agggggaaac ccctatcctg ggattcctcc     3060

tgagcggctc ttcaaccttc tgaagaccgg ccaccggatg gagaggccag acaactgcag     3120

cgaggagatg taccgcctga tgctgcaatg ctggaagcag gagccggaca aaaggccggt     3180

gtttgcggac atcagcaaag acctggagaa gatgatggtt aagaggagag actacttgga     3240

ccttgcggcg tccactccat ctgactccct gatttatgac gacggcctct cagaggagga     3300

gacaccgctg gtggactgta ataatgcccc cctccctcga gccctccctt ccacatggat     3360

tgaaaacaaa ctctatggta gaatttccca tgcatttact agattctagc accgctgtcc     3420

cctctgcact atccttcctc tctgtgatgc tttttaaaaa tgtttctggt ctgaacaaaa     3480

ccaaagtctg ctctgaacct ttttatttgt aaatgtctga ctttgcatcc agtttacatt     3540

taggcattat tgcaactatg tttttctaaa aggaagtgaa aataagtgta attaccacat     3600

tgcccagcaa cttaggatgg tagaggaaaa aacagatcag ggcggaactc tcaggggaga     3660

ccaagaacag gttgaataag gcgcttctgg ggtgggaatc aagtcatagt acttctactt     3720

taactaagtg gataaatata caaatctggg gaggtattca gttgagaaag gagccaccag     3780

caccactcag cctgcactgg gagcacagcc aggttccccc agacccctcc tgggcaggca     3840

ggtgcctctc agaggccacc cggcactggc gagcagccac tggccaagcc tcagccccag     3900

tcccagccac atgtcctcca tcaggggtag cgaggttgca ggagctggct ggccctggga     3960

ggacgcaccc ccactgctgt tttcacatcc tttcccttac ccaccttcag gacggttgtc     4020

acttatgaag tcagtgctaa agctggagca gttgcttttt gaaagaacat ggtctgtggt     4080

gctgtggtct tacaatggac agtaaatatg gttcttgcca aaactccttc ttttgtcttt     4140

gattaaatac tagaaattta aaaaaaaaaa aaaa                                 4174


<210> 4
<211> 5629
<212> DNA
<213> Homo sapiens

<400> 4
agtcccgcga ccgaagcagg gcgcgcagca gcgctgagtg ccccggaacg tgcgtcgcgc       60

ccccagtgtc cgtcgcgtcc gccgcgcccc gggcggggat ggggcggcca gactgagcgc      120

cgcacccgcc atccagaccc gccggcccta gccgcagtcc ctccagccgt ggccccagcg      180

cgcacgggcg atggcgaagg cgacgtccgg tgccgcgggg ctgcgtctgc tgttgctgct      240

gctgctgccg ctgctaggca aagtggcatt gggcctctac ttctcgaggg atgcttactg      300

ggagaagctg tatgtggacc aggcggccgg cacgcccttg ctgtacgtcc atgccctgcg      360

ggacgcccct gaggaggtgc ccagcttccg cctgggccag catctctacg gcacgtaccg      420

cacacggctg catgagaaca actggatctg catccaggag gacaccggcc tcctctacct      480

taaccggagc ctggaccata gctcctggga gaagctcagt gtccgcaacc gcggctttcc      540

cctgctcacc gtctacctca aggtcttcct gtcacccaca tcccttcgtg agggcgagtg      600

ccagtggcca ggctgtgccc gcgtatactt ctccttcttc aacacctcct ttccagcctg      660

cagctccctc aagccccggg agctctgctt cccagagaca aggccctcct tccgcattcg      720

ggagaaccga cccccaggca ccttccacca gttccgcctg ctgcctgtgc agttcttgtg      780

ccccaacatc agcgtggcct acaggctcct ggagggtgag ggtctgccct tccgctgcgc      840

cccggacagc ctggaggtga gcacgcgctg ggccctggac cgcgagcagc gggagaagta      900

cgagctggtg gccgtgtgca ccgtgcacgc cggcgcgcgc gaggaggtgg tgatggtgcc      960

cttcccggtg accgtgtacg acgaggacga ctcggcgccc accttccccg cgggcgtcga     1020

caccgccagc gccgtggtgg agttcaagcg gaaggaggac accgtggtgg ccacgctgcg     1080

tgtcttcgat gcagacgtgg tacctgcatc aggggagctg gtgaggcggt acacaagcac     1140

gctgctcccc ggggacacct gggcccagca gaccttccgg gtggaacact ggcccaacga     1200

gacctcggtc caggccaacg gcagcttcgt gcgggcgacc gtacatgact ataggctggt     1260

tctcaaccgg aacctctcca tctcggagaa ccgcaccatg cagctggcgg tgctggtcaa     1320

tgactcagac ttccagggcc caggagcggg cgtcctcttg ctccacttca acgtgtcggt     1380

gctgccggtc agcctgcacc tgcccagtac ctactccctc tccgtgagca ggagggctcg     1440

ccgatttgcc cagatcggga aagtctgtgt ggaaaactgc caggcattca gtggcatcaa     1500

cgtccagtac aagctgcatt cctctggtgc caactgcagc acgctagggg tggtcacctc     1560

agccgaggac acctcgggga tcctgtttgt gaatgacacc aaggccctgc ggcggcccaa     1620

gtgtgccgaa cttcactaca tggtggtggc caccgaccag cagacctcta ggcaggccca     1680

ggcccagctg cttgtaacag tggaggggtc atatgtggcc gaggaggcgg gctgccccct     1740

gtcctgtgca gtcagcaaga gacggctgga gtgtgaggag tgtggcggcc tgggctcccc     1800

aacaggcagg tgtgagtgga ggcaaggaga tggcaaaggg atcaccagga acttctccac     1860

ctgctctccc agcaccaaga cctgccccga cggccactgc gatgttgtgg agacccaaga     1920

catcaacatt tgccctcagg actgcctccg gggcagcatt gttgggggac acgagcctgg     1980

ggagccccgg gggattaaag ctggctatgg cacctgcaac tgcttccctg aggaggagaa     2040

gtgcttctgc gagcccgaag acatccagga tccactgtgc gacgagctgt gccgcacggt     2100

gatcgcagcc gctgtcctct tctccttcat cgtctcggtg ctgctgtctg ccttctgcat     2160

ccactgctac cacaagtttg cccacaagcc acccatctcc tcagctgaga tgaccttccg     2220

gaggcccgcc caggccttcc cggtcagcta ctcctcttcc ggtgcccgcc ggccctcgct     2280

ggactccatg gagaaccagg tctccgtgga tgccttcaag atcctggagg atccaaagtg     2340

ggaattccct cggaagaact tggttcttgg aaaaactcta ggagaaggcg aatttggaaa     2400

agtggtcaag gcaacggcct tccatctgaa aggcagagca gggtacacca cggtggccgt     2460

gaagatgctg aaagagaacg cctccccgag tgagcttcga gacctgctgt cagagttcaa     2520

cgtcctgaag caggtcaacc acccacatgt catcaaattg tatggggcct gcagccagga     2580

tggcccgctc ctcctcatcg tggagtacgc caaatacggc tccctgcggg gcttcctccg     2640

cgagagccgc aaagtggggc ctggctacct gggcagtgga ggcagccgca actccagctc     2700

cctggaccac ccggatgagc gggccctcac catgggcgac ctcatctcat ttgcctggca     2760

gatctcacag gggatgcagt atctggccga gatgaagctc gttcatcggg acttggcagc     2820

cagaaacatc ctggtagctg aggggcggaa gatgaagatt tcggatttcg gcttgtcccg     2880

agatgtttat gaagaggatt cctacgtgaa gaggagccag ggtcggattc cagttaaatg     2940

gatggcaatt gaatcccttt ttgatcatat ctacaccacg caaagtgatg tatggtcttt     3000

tggtgtcctg ctgtgggaga tcgtgaccct agggggaaac ccctatcctg ggattcctcc     3060

tgagcggctc ttcaaccttc tgaagaccgg ccaccggatg gagaggccag acaactgcag     3120

cgaggagatg taccgcctga tgctgcaatg ctggaagcag gagccggaca aaaggccggt     3180

gtttgcggac atcagcaaag acctggagaa gatgatggtt aagaggagag actacttgga     3240

ccttgcggcg tccactccat ctgactccct gatttatgac gacggcctct cagaggagga     3300

gacaccgctg gtggactgta ataatgcccc cctccctcga gccctccctt ccacatggat     3360

tgaaaacaaa ctctatggca tgtcagaccc gaactggcct ggagagagtc ctgtaccact     3420

cacgagagct gatggcacta acactgggtt tccaagatat ccaaatgata gtgtatatgc     3480

taactggatg ctttcaccct cagcggcaaa attaatggac acgtttgata gttaacattt     3540

ctttgtgaaa ggtaatggac tcacaagggg aagaaacatg ctgagaatgg aaagtctacc     3600

ggccctttct ttgtgaacgt cacattggcc gagccgtgtt cagttcccag gtggcagact     3660

cgtttttggt agtttgtttt aacttccaag gtggttttac ttctgatagc cggtgatttt     3720

ccctcctagc agacatgcca caccgggtaa gagctctgag tcttagtggt taagcattcc     3780

tttctcttca gtgcccagca gcacccagtg ttggtctgtg tccatcagtg accaccaaca     3840

ttctgtgttc acatgtgtgg gtccaacact tactacctgg tgtatgaaat tggacctgaa     3900

ctgttggatt tttctagttg ccgccaaaca aggcaaaaaa atttaaacat gaagcacaca     3960

cacaaaaaag gcagtaggaa aaatgctggc cctgatgacc tgtccttatt cagaatgaga     4020

gactgcgggg ggggcctggg ggtagtgtca atgcccctcc agggctggag gggaagaggg     4080

gccccgagga tgggcctggg ctcagcattc gagatcttga gaatgatttt tttttaatca     4140

tgcaaccttt ccttaggaag acatttggtt ttcatcatga ttaagatgat tcctagattt     4200

agcacaatgg agagattcca tgccatcttt actatgtgga tggtggtatc agggaagagg     4260

gctcacaaga cacatttgtc ccccgggccc accacatcat cctcacgtgt tcggtactga     4320

gcagccacta cccctgatga gaacagtatg aagaaagggg gctgttggag tcccagaatt     4380

gctgacagca gaggctttgc tgctgtgaat cccacctgcc accagcctgc agcacacccc     4440

acagccaagt agaggcgaaa gcagtggctc atcctacctg ttaggagcag gtagggcttg     4500

tactcacttt aatttgaatc ttatcaactt actcataaag ggacaggcta gctagctgtg     4560

ttagaagtag caatgacaat gaccaaggac tgctacacct ctgattacaa ttctgatgtg     4620

aaaaagatgg tgtttggctc ttatagagcc tgtgtgaaag gcccatggat cagctcttcc     4680

tgtgtttgta atttaatgct gctacaagat gtttctgttt cttagattct gaccatgact     4740

cataagcttc ttgtcattct tcattgcttg tttgtggtca cagatgcaca acactcctcc     4800

agtcttgtgg gggcagcttt tgggaagtct cagcagctct tctggctgtg ttgtcagcac     4860

tgtaacttcg cagaaaagag tcggattacc aaaacactgc ctgctcttca gacttaaagc     4920

actgatagga cttaaaatag tctcattcaa atactgtatt ttatataggc atttcacaaa     4980

aacagcaaaa ttgtggcatt ttgtgaggcc aaggcttgga tgcgtgtgta atagagcctt     5040

gtggtgtgtg cgcacacacc cagagggaga gtttgaaaaa tgcttattgg acacgtaacc     5100

tggctctaat ttgggctgtt tttcagatac actgtgataa gttcttttac aaatatctat     5160

agacatggta aacttttggt tttcagatat gcttaatgat agtcttacta aatgcagaaa     5220

taagaataaa ctttctcaaa ttattaaaaa tgcctacaca gtaagtgtga attgctgcaa     5280

caggtttgtt ctcaggaggg taagaactcc aggtctaaac agctgaccca gtgatgggga     5340

atttatcctt gaccaattta tccttgacca ataacctaat tgtctattcc tgagttataa     5400

aagtccccat ccttattagc tctactggaa ttttcataca cgtaaatgca gaagttacta     5460

agtattaagt attactgagt attaagtagt aatctgtcag ttattaaaat ttgtaaaatc     5520

tatttatgaa aggtcattaa accagatcat gttccttttt ttgtaatcaa ggtgactaag     5580

aaaatcagtt gtgtaaataa aatcatgtat cataaaaaaa aaaaaaaaa                 5629


<210> 5
<211> 110
<212> DNA
<213> Unknown 

<220>
<223> Description of Unknown: PIK3CA
      polynucleotide

<400> 5
ttcgaaagac cctagcctta gataaaactg agcaagaggc tttggagtat ttcatgaaac       60

aaatgaatga tgcacatcat ggtggctgga caacaaaaat ggattggatc                 110


<210> 6
<211> 110
<212> DNA
<213> Unknown 

<220>
<223> Description of Unknown: PIK3CA
      mutant polynucleotide

<400> 6
ttcgaaagac cctagcctta gataaaactg agcaagaggc tttggagtat ttcatgaaac       60

aaattaatga tgcacatcat ggtggctgga caacaaaaat ggattggatc                 110


<210> 7
<211> 110
<212> DNA
<213> Unknown 

<220>
<223> Description of Unknown: PIK3CA
      mutant polynucleotide

<400> 7
ttcgaaagac cctagcctta gataaaactg agcaagagac tttggagtat ttcatgaaac       60

aaattaatga tgcacatcat ggtggctgga caacaaaaat ggattggatc                 110


<210> 8
<211> 110
<212> DNA
<213> Unknown 

<220>
<223> Description of Unknown: PIK3CA
      mutant polynucleotide

<400> 8
ttcgaaagac cctagcctta gataaaactg aacaagaggc tttggagtat ttcatgaaac       60

aaattaatga tgcacatcat ggtggctgga caacaaaaat ggattggatc                 110


<210> 9
<211> 110
<212> DNA
<213> Unknown 

<220>
<223> Description of Unknown: PIK3CA
      mutant polynucleotide

<400> 9
ttcgaaagac actagccgta gataaaactg agcaagaggc tttggagtat ttcatgaaac       60

aaattaatga tgcacatcat ggtggctgga caacaaaaat ggattggatc                 110


<210> 10
<211> 110
<212> DNA
<213> Unknown 

<220>
<223> Description of Unknown: PIK3CA
      mutant polynucleotide

<400> 10
ttcgaaagac cctagcctta gataaaactg agcaagaggc tttggagtat ttcatgaaac       60

aaattaatga tgcacatcat agtggctgga caacaaaaat ggattggatc                 110


<210> 11
<211> 109
<212> DNA
<213> Unknown 

<220>
<223> Description of Unknown: PIK3CA
      mutant polynucleotide

<400> 11
ttcgaaagac cctagccgta gataaactga gcaagaggct ttggagtatt tcatgaaaca       60

aattaatgat gcacatcatg gtggctggac aacaaaaatg gattggatc                  109


<210> 12
<211> 35
<212> PRT
<213> Unknown 

<220>
<223> Description of Unknown: PIK3CA
      polypeptide

<400> 12
Arg Lys Thr Leu Ala Leu Asp Lys Thr Glu Gln Glu Ala Leu Glu Tyr 
1               5                   10                  15      


Glu Met Lys Gln Met Asn Asp Ala His His Gly Gly Trp Thr Thr Lys 
            20                  25                  30          


Met Asp Trp 
        35  



