                         SEQUENCE LISTING

<110>  GELLMAN, SAMUEL H.
       CHECCO, JAMES W.
 
<120>  ALPHA/BETA-PEPTIDE MIMICS OF Z-DOMAIN PEPTIDES

<130>  09820.617

<140>  xx/yyy,zzz
<141>  2015-01-21

<150>  US 61/930,449
<151>  2014-01-22

<160>  106   

<170>  PatentIn version 3.5

<210>  1
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Nle

<400>  1

Lys Glu Xaa His Asn Arg Tyr Ala Ile Glu Ala Ala Leu Asp Pro Asn 
1               5                   10                  15      


Leu Asn Asp Gln Gln Phe His Ala Lys Ile Trp Ser Ile Ile Asp Asp 
            20                  25                  30          


Pro Ser 
        


<210>  2
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Nle

<220>
<221>  DISULFID
<222>  (14)..(25)

<400>  2

Lys Glu Xaa His Asn Arg Tyr Ala Ile Glu Ala Ala Leu Cys Pro Asn 
1               5                   10                  15      


Leu Asn Asp Gln Gln Phe His Ala Cys Ile Trp Ser Ile Ile Asp Asp 
            20                  25                  30          


Pro Ser 
        


<210>  3
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  DISULFID
<222>  (1)..(36)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  2-aminocyclopentanecarboxylic acid

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  2-aminocyclopentanecarboxylic acid

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  2-aminocyclopentanecarboxylic acid

<400>  3

Cys Asn Lys Glu Xaa His Asn Ala Tyr Ala Ile Glu Ile Ala Leu Leu 
1               5                   10                  15      


Pro Asn Leu Asn Asp Gln Gln Phe His Ala Xaa Ile Trp Xaa Leu Ile 
            20                  25                  30          


Asp Asp Pro Cys Gln 
        35          


<210>  4
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  2-aminocyclopentanecarboxylic acid

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  2-aminocyclopentanecarboxylic acid

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  2-aminocyclopentanecarboxylic acid

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  2-aminocyclopentanecarboxylic acid

<400>  4

Lys Glu Xaa His Asn Ala Xaa Ala Ile Glu Ile Ala Leu Leu Pro Asn 
1               5                   10                  15      


Leu Asn Asp Gln Gln Phe His Ala Xaa Ile Trp Xaa Leu Ile Asp Asp 
            20                  25                  30          


Pro Ser 
        


<210>  5
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide

<400>  5

Phe Asn Lys Glu Ala Leu Leu Arg Tyr Lys Glu Ala Ala Leu Asp Pro 
1               5                   10                  15      


Asn Leu Asn Leu Tyr Gln Arg Ile Ala Lys Ile Val Ser Ile Asp Asp 
            20                  25                  30          


Asp Ala 
        


<210>  6
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide

<400>  6

Phe Asn Lys Glu Ala Leu Leu Arg Tyr Lys Glu Ala Ala Leu Asp Pro 
1               5                   10                  15      


Asn Leu Gly Gly Gly Gly Gly Asn Leu Tyr Gln Arg Ile Ala Lys Ile 
            20                  25                  30          


Val Ser Ile Asp Asp Asp Ala 
        35                  


<210>  7
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide

<400>  7

Phe Asn Lys Glu Ala Leu Leu Arg Tyr Lys Glu Ala Ala Leu Asp Pro 
1               5                   10                  15      


Asn Leu Gly Gly Gly Gly Gly Gly Asn Leu Tyr Gln Arg Ile Ala Lys 
            20                  25                  30          


Ile Val Ser Ile Asp Asp Asp Ala 
        35                  40  


<210>  8
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide

<400>  8

Arg Arg Leu Tyr Glu Glu Ile Arg Arg Ile Val Glu Glu Asp Arg Arg 
1               5                   10                  15      


Ala 
    


<210>  9
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide

<400>  9

Ala Arg Leu Tyr Glu Ala Ile Ala Arg Ile Val Glu Ala Asp Ala Arg 
1               5                   10                  15      


Ala 
    


<210>  10
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide

<400>  10

Glu Glu Leu Tyr Arg Arg Ile Glu Glu Ile Val Arg Arg Asp Glu Glu 
1               5                   10                  15      


Ala 
    


<210>  11
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide

<400>  11

Ala Glu Leu Tyr Arg Ala Ile Ala Glu Ile Val Arg Ala Asp Ala Glu 
1               5                   10                  15      


Ala 
    


<210>  12
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide

<400>  12

Leu Glu Leu Tyr Arg Arg Ile Ala Glu Ile Val Arg Ile Asp Asp Glu 
1               5                   10                  15      


Ala 
    


<210>  13
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide

<400>  13

Leu Arg Leu Tyr Glu Arg Ile Ala Arg Ile Val Glu Ile Asp Asp Arg 
1               5                   10                  15      


Ala 
    


<210>  14
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aib

<400>  14

Leu Asn Leu Tyr Xaa Arg Ile Ala Lys Ile Val Ser Ile Asp Asp Xaa 
1               5                   10                  15      


Ala 
    


<210>  15
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aib

<400>  15

Leu Asn Leu Tyr Xaa Arg Ile Ala Xaa Ile Val Xaa Ile Asp Asp Xaa 
1               5                   10                  15      


Ala 
    


<210>  16
<211>  59
<212>  PRT
<213>  Homo sapiens

<400>  16

Val Asp Asn Lys Phe Asn Lys Glu Met His Asn Ala Tyr Ala Ile Glu 
1               5                   10                  15      


Ile Ala Leu Leu Pro Asn Leu Asn Asp Gln Gln Phe His Ala Phe Ile 
            20                  25                  30          


Trp Ser Leu Ile Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu 
        35                  40                  45              


Ala Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys 
    50                  55                  


<210>  17
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide

<400>  17

Val Asp Asn Lys Phe Asn Lys Glu Met His Asn Ala Tyr Ala Ile Glu 
1               5                   10                  15      


Ile Ala Leu Leu Pro Asn Leu Asn Asp Gln Gln Phe His Ala Phe Ile 
            20                  25                  30          


Trp Ser Leu Ile Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu 
        35                  40                  45              


Ala Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys 
    50                  55                  


<210>  18
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  18

Lys Glu Met His Asn Ala Tyr Ala Ile Glu Ile Ala Leu Leu Pro Asn 
1               5                   10                  15      


Leu Asn Asp Gln Gln Phe His Ala Phe Ile Trp Ser Leu Ile Asp Asp 
            20                  25                  30          


Pro Ser 
        


<210>  19
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  DISULFID
<222>  (4)..(33)

<400>  19

Lys Glu Xaa Cys Asn Ala Arg Ala Ile Glu Ala Ala Leu Asp Pro Asn 
1               5                   10                  15      


Leu Asn Asp Gln Gln Phe His Ala Lys Ile Trp Ser Ile Ile Asp Asp 
            20                  25                  30          


Cys Gly 
        


<210>  20
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  DISULFID
<222>  (4)..(33)

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Aib

<400>  20

Lys Glu Gln Cys Asn Ala Arg Ala Ile Glu Xaa Ala Leu Asp Pro Asn 
1               5                   10                  15      


Leu Asn Asp Gln Gln Phe His Xaa Lys Ile Trp Ser Ile Ile Asp Asp 
            20                  25                  30          


Cys Gly 
        


<210>  21
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  DISULFID
<222>  (4)..(33)

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Aib

<400>  21

Lys Glu Gln Cys Asn Ala Arg Ala Ile Glu Xaa Ala Leu Asp Pro Asn 
1               5                   10                  15      


Leu Asn Asp Gln Gln Phe His Xaa Lys Ile Trp Xaa Ile Ile Asp Asp 
            20                  25                  30          


Cys Gly 
        


<210>  22
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  DISULFID
<222>  (4)..(33)

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Aib

<400>  22

Lys Glu Gln Cys Asn Ala Xaa Ala Ile Glu Xaa Ala Leu Asp Pro Asn 
1               5                   10                  15      


Leu Asn Asp Gln Gln Phe His Xaa Lys Ile Trp Xaa Ile Ile Asp Asp 
            20                  25                  30          


Cys Gly 
        


<210>  23
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  DISULFID
<222>  (4)..(33)

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  2-aminocyclopentanecarboxylic acid

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  2-aminocyclopentanecarboxylic acid

<400>  23

Lys Glu Gln Cys Asn Ala Xaa Ala Ile Glu Ala Ala Leu Asp Pro Asn 
1               5                   10                  15      


Leu Asn Asp Gln Gln Phe His Xaa Lys Ile Trp Xaa Ile Ile Asp Asp 
            20                  25                  30          


Cys Gly 
        


<210>  24
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  24

Lys Glu Met His Asn Ala Tyr Ala Ile Glu Ile Ala Leu Leu Pro Asn 
1               5                   10                  15      


Leu Asn Asp Gln Gln Phe His Ala Phe Ile Trp Ser Leu Ile Asp Asp 
            20                  25                  30          


Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala Lys Lys Leu Asn Asp 
        35                  40                  45              


Ala Gln 
    50  


<210>  25
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  25

Val Asp Asn Lys Phe Asn Lys Glu Met His Asn Ala Tyr Ala Ile Glu 
1               5                   10                  15      


Ile Ala Leu Leu Pro Asn Leu Asn Asp Gln Gln Phe His Ala Phe Ile 
            20                  25                  30          


Trp Ser Leu Ile Asp Asp 
        35              


<210>  26
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  DISULFID
<222>  (10)..(39)

<400>  26

Val Asp Asn Lys Phe Asn Lys Glu Gln Cys Asn Ala Tyr Ala Ile Glu 
1               5                   10                  15      


Ile Ala Leu Leu Pro Asn Leu Asn Asp Gln Gln Phe His Ala Phe Ile 
            20                  25                  30          


Trp Ser Leu Ile Asp Asp Cys Gly 
        35                  40  


<210>  27
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide

<400>  27

Val Asp Asn Lys Phe Asn Lys Glu Gln His Asn Ala Arg Ala Ile Glu 
1               5                   10                  15      


Ala Ala Leu Asp Pro Asn Leu Asn Asp Gln Gln Phe His Ala Lys Ile 
            20                  25                  30          


Trp Ser Ile Ile Asp Asp 
        35              


<210>  28
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  DISULFID
<222>  (10)..(39)

<400>  28

Val Asp Asn Lys Phe Asn Lys Glu Gln Cys Asn Ala Arg Ala Ile Glu 
1               5                   10                  15      


Ala Ala Leu Asp Pro Asn Leu Asn Asp Gln Gln Phe His Ala Lys Ile 
            20                  25                  30          


Trp Ser Ile Ile Asp Asp Cys 
        35                  


<210>  29
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  DISULFID
<222>  (10)..(39)

<400>  29

Val Asp Asn Lys Phe Asn Lys Glu Gln Cys Asn Ala Arg Ala Ile Glu 
1               5                   10                  15      


Ala Ala Leu Asp Pro Asn Leu Asn Asp Gln Gln Phe His Ala Lys Ile 
            20                  25                  30          


Trp Ser Ile Ile Asp Asp Cys Gly 
        35                  40  


<210>  30
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  DISULFID
<222>  (10)..(39)

<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  Beta-3 Lys

<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  Beta-3 Ser

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Beta-3 Asp

<400>  30

Val Asp Asn Lys Phe Asn Lys Glu Gln Cys Asn Ala Arg Ala Ile Glu 
1               5                   10                  15      


Ala Ala Leu Asp Pro Asn Leu Asn Asp Gln Gln Phe His Ala Xaa Ile 
            20                  25                  30          


Trp Xaa Ile Ile Asp Xaa Cys Gly 
        35                  40  


<210>  31
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  DISULFID
<222>  (10)..(39)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  2-aminocyclopentanecarboxylic acid

<220>
<221>  MOD_RES
<222>  (37)..(37)
<223>  2-aminocyclopentanecarboxylic acid

<400>  31

Val Asp Asn Lys Phe Asn Lys Glu Gln Cys Asn Ala Arg Ala Ile Glu 
1               5                   10                  15      


Ala Ala Leu Asp Pro Asn Leu Asn Asp Gln Gln Phe His Xaa Lys Ile 
            20                  25                  30          


Trp Xaa Ile Ile Asp Asp Cys Gly 
        35                  40  


<210>  32
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  DISULFID
<222>  (10)..(39)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  2-aminocyclopentanecarboxylic acid

<400>  32

Val Asp Asn Lys Phe Asn Lys Glu Gln Cys Asn Ala Arg Ala Ile Glu 
1               5                   10                  15      


Ala Ala Leu Asp Pro Asn Leu Asn Asp Gln Gln Phe His Xaa Lys Ile 
            20                  25                  30          


Trp Ser Ile Ile Asp Asp Cys Gly 
        35                  40  


<210>  33
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  DISULFID
<222>  (10)..(39)

<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  2-aminocyclopentanecarboxylic acid

<400>  33

Val Asp Asn Lys Phe Asn Lys Glu Gln Cys Asn Ala Arg Ala Ile Glu 
1               5                   10                  15      


Ala Ala Leu Asp Pro Asn Leu Asn Asp Gln Gln Phe His Ala Lys Ile 
            20                  25                  30          


Trp Xaa Ile Ile Asp Asp Cys Gly 
        35                  40  


<210>  34
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  DISULFID
<222>  (10)..(39)

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  N-succinyl-3-aminopyrrolidine-4-carboxylic acid

<400>  34

Val Asp Asn Lys Phe Asn Lys Glu Gln Cys Asn Ala Arg Ala Ile Glu 
1               5                   10                  15      


Ala Ala Leu Asp Pro Asn Leu Asn Asp Gln Gln Phe His Ala Lys Ile 
            20                  25                  30          


Trp Ser Ile Ile Asp Xaa Cys Gly 
        35                  40  


<210>  35
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  DISULFID
<222>  (10)..(39)

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  Aib

<400>  35

Val Asp Asn Lys Phe Asn Lys Glu Gln Cys Asn Ala Arg Ala Ile Glu 
1               5                   10                  15      


Xaa Ala Leu Asp Pro Asn Leu Asn Asp Gln Gln Phe His Xaa Lys Ile 
            20                  25                  30          


Trp Xaa Ile Ile Asp Asp Cys Gly 
        35                  40  


<210>  36
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  DISULFID
<222>  (10)..(39)

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  2-aminocyclopentanecarboxylic acid

<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  Aib

<400>  36

Val Asp Asn Lys Phe Asn Lys Glu Gln Cys Asn Ala Arg Ala Ile Glu 
1               5                   10                  15      


Xaa Ala Leu Asp Pro Asn Leu Asn Asp Gln Gln Phe His Xaa Lys Ile 
            20                  25                  30          


Trp Xaa Ile Ile Asp Asp Cys Gly 
        35                  40  


<210>  37
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  DISULFID
<222>  (10)..(39)

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  2-aminocyclopentanecarboxylic acid

<400>  37

Val Asp Asn Lys Phe Asn Lys Glu Gln Cys Asn Ala Arg Ala Ile Glu 
1               5                   10                  15      


Xaa Ala Leu Asp Pro Asn Leu Asn Asp Gln Gln Phe His Xaa Lys Ile 
            20                  25                  30          


Trp Xaa Ile Ile Asp Asp Cys Gly 
        35                  40  


<210>  38
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  DISULFID
<222>  (10)..(39)

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  2-aminocyclopentanecarboxylic acid

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  N-succinyl-3-aminopyrrolidine-4-carboxylic acid

<400>  38

Val Asp Asn Lys Phe Asn Lys Glu Gln Cys Asn Ala Arg Ala Ile Glu 
1               5                   10                  15      


Xaa Ala Leu Asp Pro Asn Leu Asn Asp Gln Gln Phe His Xaa Lys Ile 
            20                  25                  30          


Trp Xaa Ile Ile Asp Xaa Cys Gly 
        35                  40  


<210>  39
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  DISULFID
<222>  (10)..(39)

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  2-aminocyclopentanecarboxylic acid

<220>
<221>  MOD_RES
<222>  (37)..(37)
<223>  N-succinyl-3-aminopyrrolidine-4-carboxylic acid

<400>  39

Val Asp Asn Lys Phe Asn Lys Glu Gln Cys Asn Ala Arg Ala Ile Glu 
1               5                   10                  15      


Xaa Ala Leu Asp Pro Asn Leu Asn Asp Gln Gln Phe His Xaa Lys Ile 
            20                  25                  30          


Trp Xaa Ile Ile Xaa Asp Cys Gly 
        35                  40  


<210>  40
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  DISULFID
<222>  (10)..(39)

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  2-aminocyclopentanecarboxylic acid

<400>  40

Val Asp Asn Lys Phe Asn Lys Glu Gln Cys Asn Ala Arg Ala Ile Glu 
1               5                   10                  15      


Xaa Ala Leu Asp Pro Asn Leu Asn Asp Gln Gln Phe His Xaa Lys Ile 
            20                  25                  30          


Trp Xaa Ile Ile Asp Asp Cys Gly 
        35                  40  


<210>  41
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Aib

<220>
<221>  DISULFID
<222>  (10)..(39)

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  2-aminocyclopentanecarboxylic acid

<400>  41

Val Asp Asn Lys Phe Asn Lys Glu Xaa Cys Asn Xaa Arg Ala Ile Glu 
1               5                   10                  15      


Xaa Ala Leu Asp Pro Asn Leu Asn Asp Gln Gln Phe His Xaa Lys Ile 
            20                  25                  30          


Trp Xaa Ile Ile Asp Asp Cys Gly 
        35                  40  


<210>  42
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  DISULFID
<222>  (10)..(39)

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  2-aminocyclopentanecarboxylic acid

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  2-aminocyclopentanecarboxylic acid

<400>  42

Val Asp Asn Lys Phe Asn Lys Glu Gln Cys Asn Xaa Arg Ala Ile Glu 
1               5                   10                  15      


Xaa Ala Leu Asp Pro Asn Leu Asn Asp Gln Gln Phe His Xaa Lys Ile 
            20                  25                  30          


Trp Xaa Ile Ile Asp Asp Cys Gly 
        35                  40  


<210>  43
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  2-aminocyclopentanecarboxylic acid

<220>
<221>  DISULFID
<222>  (10)..(39)

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  2-aminocyclopentanecarboxylic acid

<400>  43

Val Asp Asn Lys Phe Asn Lys Glu Xaa Cys Asn Xaa Arg Ala Ile Glu 
1               5                   10                  15      


Xaa Ala Leu Asp Pro Asn Leu Asn Asp Gln Gln Phe His Xaa Lys Ile 
            20                  25                  30          


Trp Xaa Ile Ile Asp Asp Cys Gly 
        35                  40  


<210>  44
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  2-aminocyclopentanecarboxylic acid

<220>
<221>  DISULFID
<222>  (10)..(39)

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  2-aminocyclopentanecarboxylic acid

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  2-aminocyclopentanecarboxylic acid

<220>
<221>  MOD_RES
<222>  (37)..(37)
<223>  N-succinyl-3-aminopyrrolidine-4-carboxylic acid

<400>  44

Val Asp Asn Lys Phe Asn Lys Glu Xaa Cys Asn Xaa Arg Ala Ile Glu 
1               5                   10                  15      


Xaa Ala Leu Asp Pro Asn Leu Asn Asp Gln Gln Phe His Xaa Lys Ile 
            20                  25                  30          


Trp Xaa Ile Ile Xaa Asp Cys Gly 
        35                  40  


<210>  45
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  2-aminocyclopentanecarboxylic acid

<220>
<221>  DISULFID
<222>  (10)..(39)

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  2-aminocyclopentanecarboxylic acid

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  2-aminocyclopentanecarboxylic acid

<220>
<221>  MOD_RES
<222>  (37)..(37)
<223>  2-aminocyclopentanecarboxylic acid

<400>  45

Val Asp Asn Lys Phe Asn Lys Glu Xaa Cys Asn Xaa Arg Ala Ile Glu 
1               5                   10                  15      


Xaa Ala Leu Asp Pro Asn Leu Asn Asp Gln Gln Phe His Xaa Lys Ile 
            20                  25                  30          


Trp Xaa Ile Ile Xaa Asp Cys Gly 
        35                  40  


<210>  46
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  2-aminocyclopentanecarboxylic acid

<220>
<221>  DISULFID
<222>  (7)..(36)

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  2-aminocyclopentanecarboxylic acid

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  2-aminocyclopentanecarboxylic acid

<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  2-aminocyclopentanecarboxylic acid

<400>  46

Lys Phe Asn Lys Glu Xaa Cys Asn Xaa Arg Ala Ile Glu Xaa Ala Leu 
1               5                   10                  15      


Asp Pro Asn Leu Asn Asp Gln Gln Phe His Xaa Lys Ile Trp Xaa Ile 
            20                  25                  30          


Ile Xaa Asp Cys Gly 
        35          


<210>  47
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  2-aminocyclopentanecarboxylic acid

<220>
<221>  DISULFID
<222>  (4)..(33)

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  2-aminocyclopentanecarboxylic acid

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  2-aminocyclopentanecarboxylic acid

<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  2-aminocyclopentanecarboxylic acid

<400>  47

Lys Glu Xaa Cys Asn Xaa Arg Ala Ile Glu Xaa Ala Leu Asp Pro Asn 
1               5                   10                  15      


Leu Asn Asp Gln Gln Phe His Xaa Lys Ile Trp Xaa Ile Ile Xaa Asp 
            20                  25                  30          


Cys Gly 
        


<210>  48
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  2-aminocyclopentanecarboxylic acid

<220>
<221>  DISULFID
<222>  (10)..(39)

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (37)..(37)
<223>  2-aminocyclopentanecarboxylic acid

<400>  48

Val Asp Asn Lys Phe Asn Lys Glu Xaa Cys Asn Xaa Arg Ala Ile Glu 
1               5                   10                  15      


Xaa Ala Leu Asp Pro Asn Leu Asn Asp Gln Gln Phe His Xaa Lys Ile 
            20                  25                  30          


Trp Xaa Ile Ile Xaa Asp Cys 
        35                  


<210>  49
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Beta-3 Asp

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Beta-3 Phe

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  2-aminocyclopentanecarboxylic acid

<220>
<221>  DISULFID
<222>  (10)..(39)

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (37)..(37)
<223>  2-aminocyclopentanecarboxylic acid

<400>  49

Val Xaa Asn Lys Xaa Asn Lys Glu Xaa Cys Asn Xaa Arg Ala Ile Glu 
1               5                   10                  15      


Xaa Ala Leu Asp Pro Asn Leu Asn Asp Gln Gln Phe His Xaa Lys Ile 
            20                  25                  30          


Trp Xaa Ile Ile Xaa Asp Cys 
        35                  


<210>  50
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Beta-3 Asp

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Beta-3 Phe

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  2-aminocyclopentanecarboxylic acid

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (37)..(37)
<223>  2-aminocyclopentanecarboxylic acid

<400>  50

Val Xaa Asn Lys Xaa Asn Lys Glu Xaa His Asn Xaa Arg Ala Ile Glu 
1               5                   10                  15      


Xaa Ala Leu Asp Pro Asn Leu Asn Asp Gln Gln Phe His Xaa Lys Ile 
            20                  25                  30          


Trp Xaa Ile Ile Xaa Asp 
        35              


<210>  51
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Beta-3 Phe

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  2-aminocyclopentanecarboxylic acid

<220>
<221>  DISULFID
<222>  (7)..(36)

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  2-aminocyclopentanecarboxylic acid

<400>  51

Lys Xaa Asn Lys Glu Xaa Cys Asn Xaa Arg Ala Ile Glu Xaa Ala Leu 
1               5                   10                  15      


Asp Pro Asn Leu Asn Asp Gln Gln Phe His Xaa Lys Ile Trp Xaa Ile 
            20                  25                  30          


Ile Xaa Asp Cys 
        35      


<210>  52
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  2-aminocyclopentanecarboxylic acid

<220>
<221>  DISULFID
<222>  (10)..(39)

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (37)..(37)
<223>  2-aminocyclopentanecarboxylic acid

<400>  52

Val Asp Asn Lys Phe Asn Lys Glu Xaa Cys Asn Xaa Arg Ala Ile Glu 
1               5                   10                  15      


Xaa Ala Leu Asp Pro Asn Leu Asn Asp Ala Gln Phe His Xaa Lys Ile 
            20                  25                  30          


Trp Xaa Ile Ile Xaa Asp Cys 
        35                  


<210>  53
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Beta-3 Asp

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Beta-3 Phe

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  2-aminocyclopentanecarboxylic acid

<220>
<221>  DISULFID
<222>  (10)..(39)

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (37)..(37)
<223>  2-aminocyclopentanecarboxylic acid

<400>  53

Val Xaa Asn Lys Xaa Asn Lys Glu Xaa Cys Asn Xaa Arg Ala Ile Glu 
1               5                   10                  15      


Xaa Ala Leu Asp Pro Asn Leu Asn Asp Ala Gln Phe His Xaa Lys Ile 
            20                  25                  30          


Trp Xaa Ile Ile Xaa Asp Cys 
        35                  


<210>  54
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Beta-3 Phe

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  2-aminocyclopentanecarboxylic acid

<220>
<221>  DISULFID
<222>  (7)..(36)

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  2-aminocyclopentanecarboxylic acid

<400>  54

Lys Xaa Asn Lys Glu Xaa Cys Asn Xaa Arg Ala Ile Glu Xaa Ala Leu 
1               5                   10                  15      


Asp Pro Asn Leu Asn Asp Ala Gln Phe His Xaa Lys Ile Trp Xaa Ile 
            20                  25                  30          


Ile Xaa Asp Cys 
        35      


<210>  55
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Beta-3 Asp

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Beta-3 Phe

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  2-aminocyclopentanecarboxylic acid

<220>
<221>  DISULFID
<222>  (10)..(39)

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (37)..(37)
<223>  2-aminocyclopentanecarboxylic acid

<400>  55

Val Xaa Asn Lys Xaa Asn Lys Glu Xaa Cys Asn Xaa Arg Ala Ile Glu 
1               5                   10                  15      


Xaa Ala Leu Asp Pro Asn Leu Asn Asp Gln Gln Phe His Xaa Lys Ile 
            20                  25                  30          


Trp Xaa Ile Ile Xaa Asp Cys 
        35                  


<210>  56
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  DISULFID
<222>  (10)..(39)

<400>  56

Val Asp Asn Lys Phe Asn Lys Glu Glu Cys Asn Ala Arg Ala Ile Glu 
1               5                   10                  15      


Ala Ala Leu Asp Pro Asn Leu Asn Asp Gln Gln Phe His Ala Lys Ile 
            20                  25                  30          


Trp Arg Ile Ile Asp Asp Cys Gly 
        35                  40  


<210>  57
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  DISULFID
<222>  (10)..(39)

<400>  57

Val Asp Asn Lys Phe Asn Lys Glu Glu Cys Asn Arg Arg Ala Ile Glu 
1               5                   10                  15      


Ala Ala Leu Asp Pro Asn Leu Asn Asp Gln Gln Phe His Glu Lys Ile 
            20                  25                  30          


Trp Arg Ile Ile Glu Asp Cys Gly 
        35                  40  


<210>  58
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  DISULFID
<222>  (10)..(39)

<400>  58

Val Asp Asn Lys Phe Asn Lys Glu Glu Cys Asn Arg Arg Ala Ile Glu 
1               5                   10                  15      


Ala Ala Leu Arg Pro Asn Leu Asn Asp Gln Gln Phe His Glu Glu Ile 
            20                  25                  30          


Trp Arg Ile Ile Glu Glu Cys Gly 
        35                  40  


<210>  59
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  DISULFID
<222>  (10)..(39)

<400>  59

Val Asp Asn Lys Phe Asn Lys Glu Glu Cys Asn Arg Arg Ala Ile Glu 
1               5                   10                  15      


Ala Ala Leu Arg Pro Asn Leu Asn Asp Gln Gln Phe His Arg Arg Ile 
            20                  25                  30          


Trp Glu Ile Ile Arg Arg Cys Gly 
        35                  40  


<210>  60
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  DISULFID
<222>  (10)..(39)

<400>  60

Val Asp Asn Lys Phe Asn Lys Glu Arg Cys Asn Glu Glu Ala Ile Arg 
1               5                   10                  15      


Ala Ala Leu Asp Pro Asn Leu Asn Asp Gln Gln Phe His Arg Arg Ile 
            20                  25                  30          


Trp Glu Ile Ile Arg Arg Cys Gly 
        35                  40  


<210>  61
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  DISULFID
<222>  (10)..(39)

<400>  61

Val Asp Asn Lys Phe Asn Lys Glu Arg Cys Asn Glu Glu Ala Ile Arg 
1               5                   10                  15      


Ala Ala Leu Asp Pro Asn Leu Asn Asp Gln Gln Phe His Glu Glu Ile 
            20                  25                  30          


Trp Arg Ile Ile Glu Glu Cys Gly 
        35                  40  


<210>  62
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  62

Val Asp Asn Lys Phe Asn Lys Glu Leu Gly Trp Ala Ile Gly Glu Ile 
1               5                   10                  15      


Gly Thr Leu Pro Asn Leu Asn His Gln Gln Phe Arg Ala Phe Ile Leu 
            20                  25                  30          


Ser Leu Trp Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala 
        35                  40                  45              


Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys 
    50                  55              


<210>  63
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Beta-3 Asp

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Beta-3 Phe

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  2-aminocyclopentanecarboxylic acid

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (33)..(33)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  2-aminocyclopentanecarboxylic acid

<400>  63

Val Xaa Asn Lys Xaa Asn Lys Xaa Cys Gly Xaa Arg Ile Gly Glu Xaa 
1               5                   10                  15      


Gly Thr Asp Pro Asn Leu Asn His Gln Gln Phe Arg Xaa Lys Ile Leu 
            20                  25                  30          


Xaa Ile Trp Xaa Asp Cys 
        35              


<210>  64
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Beta-3 Asp

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Beta-3 Phe

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  2-aminocyclopentanecarboxylic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (33)..(33)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  2-aminocyclopentanecarboxylic acid

<400>  64

Val Xaa Asn Lys Xaa Asn Lys Xaa Cys Gly Trp Arg Ile Gly Glu Xaa 
1               5                   10                  15      


Gly Thr Asp Pro Asn Leu Asn His Gln Gln Phe Arg Xaa Lys Ile Leu 
            20                  25                  30          


Xaa Ile Trp Xaa Asp Cys 
        35              


<210>  65
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Beta-3 Asp

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Beta-3 Phe

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  2-aminocyclopentanecarboxylic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (33)..(33)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  2-aminocyclopentanecarboxylic acid

<400>  65

Val Xaa Asn Lys Xaa Asn Lys Xaa Leu Gly Trp Arg Ile Gly Glu Xaa 
1               5                   10                  15      


Gly Thr Asp Pro Asn Leu Asn His Gln Gln Phe Arg Xaa Lys Ile Leu 
            20                  25                  30          


Xaa Ile Trp Xaa Asp Pro 
        35              


<210>  66
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Beta-3 Asp

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Beta-3 Phe

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  2-aminocyclopentanecarboxylic acid

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Beta-3 Trp

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (33)..(33)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  2-aminocyclopentanecarboxylic acid

<400>  66

Val Xaa Asn Lys Xaa Asn Lys Xaa Cys Gly Xaa Arg Ile Gly Glu Xaa 
1               5                   10                  15      


Gly Thr Asp Pro Asn Leu Asn His Gln Gln Phe Arg Xaa Lys Ile Leu 
            20                  25                  30          


Xaa Ile Trp Xaa Asp Cys 
        35              


<210>  67
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  2-aminocyclopentanecarboxylic acid

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  2-aminocyclopentanecarboxylic acid

<400>  67

Asn Lys Xaa Cys Gly Xaa Arg Ile Gly Glu Xaa Gly Thr Asp Pro Asn 
1               5                   10                  15      


Leu Asn His Gln Gln Phe Arg Xaa Lys Ile Leu Xaa Ile Trp Xaa Asp 
            20                  25                  30          


Cys 
    


<210>  68
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Beta-3 Asp

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Beta-3 Phe

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  2-aminocyclopentanecarboxylic acid

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (33)..(33)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  2-aminocyclopentanecarboxylic acid

<400>  68

Val Xaa Asn Lys Xaa Asn Lys Xaa Leu Gly Xaa Arg Ile Gly Glu Xaa 
1               5                   10                  15      


Gly Thr Asp Pro Asn Leu Asn His Gln Gln Phe Arg Xaa Lys Ile Leu 
            20                  25                  30          


Xaa Ile Trp Xaa Asp Pro 
        35              


<210>  69
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  2-aminocyclopentanecarboxylic acid

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  2-aminocyclopentanecarboxylic acid

<400>  69

Asn Lys Xaa Leu Gly Trp Arg Ile Gly Glu Xaa Gly Thr Asp Pro Asn 
1               5                   10                  15      


Leu Asn His Gln Gln Phe Arg Xaa Lys Ile Leu Xaa Ile Trp Xaa Asp 
            20                  25                  30          


Pro 
    


<210>  70
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Beta-3 Asp

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Beta-3 Phe

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  2-aminocyclopentanecarboxylic acid

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (33)..(33)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  2-aminocyclopentanecarboxylic acid

<400>  70

Val Xaa Asn Lys Xaa Asn Lys Xaa Leu Gly Trp Ala Ile Gly Glu Leu 
1               5                   10                  15      


Gly Thr Asp Pro Asn Leu Asn His Gln Gln Phe Arg Xaa Lys Ala Leu 
            20                  25                  30          


Xaa Leu Trp Xaa Asp Pro 
        35              


<210>  71
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Beta-3 Asp

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Beta-3 Phe

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  2-aminocyclopentanecarboxylic acid

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (33)..(33)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  2-aminocyclopentanecarboxylic acid

<400>  71

Val Xaa Asn Lys Xaa Asn Lys Xaa Cys Gly Trp Ala Ile Gly Glu Leu 
1               5                   10                  15      


Gly Thr Asp Pro Asn Leu Asn His Gln Gln Phe Arg Xaa Lys Ala Leu 
            20                  25                  30          


Xaa Leu Trp Xaa Asp Cys 
        35              


<210>  72
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  2-aminocyclopentanecarboxylic acid

<400>  72

Cys Gly Trp Arg Ile Gly Glu Xaa Gly Thr Asp Pro Asn Leu Asn His 
1               5                   10                  15      


Gln Gln Phe Arg Xaa Lys Ile Leu Xaa Ile Trp Xaa Asp Cys 
            20                  25                  30  


<210>  73
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  2-aminocyclopentanecarboxylic acid

<400>  73

Leu Gly Trp Arg Ile Gly Glu Xaa Gly Thr Asp Pro Asn Leu Asn His 
1               5                   10                  15      


Gln Gln Phe Arg Xaa Lys Ile Leu Xaa Ile Trp Xaa Asp Pro 
            20                  25                  30  


<210>  74
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  2-aminocyclopentanecarboxylic acid

<400>  74

Trp Arg Ile Gly Glu Xaa Gly Thr Asp Pro Asn Leu Asn His Gln Gln 
1               5                   10                  15      


Phe Arg Xaa Lys Ile Leu Xaa Ile Trp Xaa Asp Pro 
            20                  25              


<210>  75
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Beta-3 Trp

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  2-aminocyclopentanecarboxylic acid

<400>  75

Xaa Arg Ile Gly Glu Xaa Gly Thr Asp Pro Asn Leu Asn His Gln Gln 
1               5                   10                  15      


Phe Arg Xaa Lys Ile Leu Xaa Ile Trp Xaa Asp Pro 
            20                  25              


<210>  76
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  2-aminocyclopentanecarboxylic acid

<400>  76

Leu Gly Trp Arg Ile Gly Glu Xaa Gly Thr Asp Pro Asn Leu Asn His 
1               5                   10                  15      


Gln Gln Phe Arg Xaa Lys Ile Leu Xaa Ile Trp Xaa 
            20                  25              


<210>  77
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2-aminocyclopentanecarboxylic acid

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  2-aminocyclopentanecarboxylic acid

<400>  77

Xaa Trp Arg Ile Gly Glu Xaa Gly Thr Asp Pro Asn Leu Asn His Gln 
1               5                   10                  15      


Gln Phe Arg Xaa Lys Ile Leu Xaa Ile Trp Xaa 
            20                  25          


<210>  78
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2-aminocyclopentanecarboxylic acid

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (22)..(22)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  2-aminocyclopentanecarboxylic acid

<400>  78

Xaa Leu Gly Trp Arg Ile Gly Glu Xaa Gly Thr Asp Pro Asn Leu Asn 
1               5                   10                  15      


His Gln Gln Phe Arg Xaa Lys Ile Leu Xaa Ile Trp Xaa 
            20                  25                  


<210>  79
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2-aminocyclopentanecarboxylic acid

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (22)..(22)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  2-aminocyclopentanecarboxylic acid

<400>  79

Xaa Leu Gly Trp Cys Ile Gly Glu Xaa Gly Thr Asp Pro Asn Leu Asn 
1               5                   10                  15      


His Gln Gln Phe Arg Xaa Lys Ile Leu Xaa Cys Trp Xaa 
            20                  25                  


<210>  80
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2-aminocyclopentanecarboxylic acid

<220>
<221>  MOD_RES
<222>  (22)..(22)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  2-aminocyclopentanecarboxylic acid

<400>  80

Xaa Leu Gly Trp Arg Ile Gly Glu Cys Gly Thr Asp Pro Asn Leu Asn 
1               5                   10                  15      


His Gln Gln Phe Arg Xaa Cys Ile Leu Xaa Ile Trp Xaa 
            20                  25                  


<210>  81
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  81

Val Asp Asn Lys Phe Asn Lys Glu Met Arg Asn Ala Tyr Trp Glu Ile 
1               5                   10                  15      


Ala Leu Leu Pro Asn Leu Asn Asn Gln Gln Lys Arg Ala Phe Ile Arg 
            20                  25                  30          


Ser Leu Tyr Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala 
        35                  40                  45              


Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys 
    50                  55              


<210>  82
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  82

Val Glu Asn Lys Phe Asn Lys Glu Met Arg Asn Ala Tyr Trp Glu Ile 
1               5                   10                  15      


Ala Leu Leu Pro Asn Leu Asn Asn Gln Gln Lys Arg Ala Phe Ile Arg 
            20                  25                  30          


Ser Leu Tyr Asp Asp Pro Gly 
        35                  


<210>  83
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  DISULFID
<222>  (5)..(39)

<400>  83

Val Glu Asn Lys Cys Asn Lys Glu Met Arg Asn Ala Tyr Trp Glu Ile 
1               5                   10                  15      


Ala Leu Leu Pro Asn Leu Asn Asn Gln Gln Lys Arg Ala Phe Ile Arg 
            20                  25                  30          


Ser Leu Tyr Asp Asp Pro Cys 
        35                  


<210>  84
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  DISULFID
<222>  (5)..(39)

<400>  84

Val Glu Asn Lys Cys Asn Lys Glu Met Arg Asn Ala Tyr Trp Glu Ile 
1               5                   10                  15      


Ala Leu Leu Pro Asn Leu Asn Asn Gln Gln Lys Arg Ala Phe Ile Arg 
            20                  25                  30          


Ser Leu Tyr Asp Asp Pro Cys 
        35                  


<210>  85
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide

<400>  85

Phe Asn Lys Glu Met Arg Asn Arg Tyr Trp Glu Ala Ala Leu Asp Pro 
1               5                   10                  15      


Asn Leu Asn Asn Gln Gln Lys Arg Ala Lys Ile Arg Ser Ile Tyr Asp 
            20                  25                  30          


Asp Pro Ser 
        35  


<210>  86
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  DISULFID
<222>  (1)..(35)

<400>  86

Cys Asn Lys Glu Met Arg Asn Arg Tyr Trp Glu Ala Ala Leu Asp Pro 
1               5                   10                  15      


Asn Leu Asn Asn Gln Gln Lys Arg Ala Lys Ile Arg Ser Ile Tyr Asp 
            20                  25                  30          


Asp Pro Cys 
        35  


<210>  87
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  DISULFID
<222>  (1)..(35)

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Homocysteine (Hey)

<220>
<221>  MOD_RES
<222>  (35)..(35)
<223>  Homocysteine (Hey)

<400>  87

Xaa Asn Lys Glu Met Arg Asn Arg Tyr Trp Glu Ala Ala Leu Asp Pro 
1               5                   10                  15      


Asn Leu Asn Asn Gln Gln Lys Arg Ala Lys Ile Arg Ser Ile Tyr Asp 
            20                  25                  30          


Asp Pro Xaa 
        35  


<210>  88
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  2-aminocyclopentanecarboxylic acid

<220>
<221>  DISULFID
<222>  (9)..(38)

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (33)..(33)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  2-aminocyclopentanecarboxylic acid

<400>  88

Val Asp Asn Lys Phe Asn Lys Xaa Cys Arg Xaa Arg Tyr Trp Glu Xaa 
1               5                   10                  15      


Ala Leu Asp Pro Asn Leu Asn Asn Gln Gln Lys Arg Xaa Lys Ile Arg 
            20                  25                  30          


Xaa Ile Tyr Xaa Asp Cys 
        35              


<210>  89
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  2-aminocyclopentanecarboxylic acid

<220>
<221>  DISULFID
<222>  (4)..(33)

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  2-aminocyclopentanecarboxylic acid

<400>  89

Asn Lys Xaa Cys Arg Xaa Arg Tyr Trp Glu Xaa Ala Leu Asp Pro Asn 
1               5                   10                  15      


Leu Asn Asn Gln Gln Lys Arg Xaa Lys Ile Arg Xaa Ile Tyr Xaa Asp 
            20                  25                  30          


Cys 
    


<210>  90
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  DISULFID
<222>  (1)..(30)

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  2-aminocyclopentanecarboxylic acid

<400>  90

Cys Arg Xaa Arg Tyr Trp Glu Xaa Ala Leu Asp Pro Asn Leu Asn Asn 
1               5                   10                  15      


Gln Gln Lys Arg Xaa Lys Ile Arg Xaa Ile Tyr Xaa Asp Cys 
            20                  25                  30  


<210>  91
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  DISULFID
<222>  (4)..(33)

<400>  91

Asn Lys Glu Cys Arg Asn Arg Tyr Trp Glu Ala Ala Leu Asp Pro Asn 
1               5                   10                  15      


Leu Asn Asn Gln Gln Lys Arg Ala Lys Ile Arg Ser Ile Tyr Asp Asp 
            20                  25                  30          


Cys 
    


<210>  92
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  DISULFID
<222>  (1)..(35)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  2-aminocyclopentanecarboxylic acid

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (32)..(32)
<223>  2-aminocyclopentanecarboxylic acid

<400>  92

Cys Asn Lys Xaa Met Arg Xaa Arg Tyr Trp Glu Xaa Ala Leu Asp Pro 
1               5                   10                  15      


Asn Leu Asn Asn Gln Gln Lys Arg Xaa Lys Ile Arg Xaa Ile Tyr Xaa 
            20                  25                  30          


Asp Pro Cys 
        35  


<210>  93
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  DISULFID
<222>  (1)..(35)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  2-aminocyclopentanecarboxylic acid

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  3-aminopyrrolidine-4-carboxylic acid

<400>  93

Cys Asn Lys Xaa Met Arg Xaa Arg Tyr Trp Glu Xaa Ala Leu Asp Pro 
1               5                   10                  15      


Asn Leu Asn Asn Gln Gln Lys Arg Xaa Lys Ile Arg Xaa Ile Tyr Asp 
            20                  25                  30          


Asp Pro Cys 
        35  


<210>  94
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  2-aminocyclopentanecarboxylic acid

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (32)..(32)
<223>  2-aminocyclopentanecarboxylic acid

<400>  94

Phe Asn Lys Xaa Met Arg Xaa Arg Tyr Trp Glu Xaa Ala Leu Asp Pro 
1               5                   10                  15      


Asn Leu Asn Asn Gln Gln Lys Arg Xaa Lys Ile Arg Xaa Ile Tyr Xaa 
            20                  25                  30          


Asp Pro Ser 
        35  


<210>  95
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  2-aminocyclopentanecarboxylic acid

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  3-aminopyrrolidine-4-carboxylic acid

<400>  95

Phe Asn Lys Xaa Met Arg Xaa Arg Tyr Trp Glu Xaa Ala Leu Asp Pro 
1               5                   10                  15      


Asn Leu Asn Asn Gln Gln Lys Arg Xaa Lys Ile Arg Xaa Ile Tyr Asp 
            20                  25                  30          


Asp Pro Ser 
        35  


<210>  96
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  2-aminocyclopentanecarboxylic acid

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  3-aminopyrrolidine-4-carboxylic acid

<400>  96

Phe Asn Lys Xaa Met Arg Xaa Arg Tyr Trp Xaa Ala Ala Leu Asp Pro 
1               5                   10                  15      


Asn Leu Asn Asn Gln Gln Lys Arg Xaa Lys Ile Arg Xaa Ile Tyr Asp 
            20                  25                  30          


Asp Pro Ser 
        35  


<210>  97
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  2-aminocyclopentanecarboxylic acid

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  3-aminopyrrolidine-4-carboxylic acid

<400>  97

Phe Asn Lys Xaa Met Arg Xaa Arg Tyr Trp Glu Xaa Ala Leu Asp Pro 
1               5                   10                  15      


Asn Leu Asn Asn Xaa Gln Lys Arg Xaa Lys Ile Arg Xaa Ile Tyr Asp 
            20                  25                  30          


Asp Pro Ser 
        35  


<210>  98
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  2-aminocyclopentanecarboxylic acid

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (33)..(33)
<223>  2-aminocyclopentanecarboxylic acid

<400>  98

Phe Asn Lys Xaa Met Arg Xaa Arg Tyr Trp Glu Xaa Ala Leu Asp Pro 
1               5                   10                  15      


Asn Leu Asn Asn Gln Gln Lys Arg Xaa Lys Ile Arg Xaa Ile Tyr Asp 
            20                  25                  30          


Xaa Pro Ser 
        35  


<210>  99
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  DISULFID
<222>  (4)..(35)

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  3-aminopyrrolidine-4-carboxylic acid

<400>  99

Phe Asn Lys Cys Met Arg Xaa Arg Tyr Trp Glu Xaa Ala Leu Asp Pro 
1               5                   10                  15      


Asn Leu Asn Asn Gln Gln Lys Arg Xaa Lys Ile Arg Xaa Ile Tyr Asp 
            20                  25                  30          


Asp Pro Cys 
        35  


<210>  100
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  DISULFID
<222>  (4)..(35)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Homocysteine (Hey)

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (35)..(35)
<223>  Homocysteine (Hey)

<400>  100

Phe Asn Lys Xaa Met Arg Xaa Arg Tyr Trp Glu Xaa Ala Leu Asp Pro 
1               5                   10                  15      


Asn Leu Asn Asn Gln Gln Lys Arg Xaa Lys Ile Arg Xaa Ile Tyr Asp 
            20                  25                  30          


Asp Pro Xaa 
        35  


<210>  101
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  [2-(2-amino-ethoxy)-ethoxy]acetic acid

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Nle

<400>  101

Xaa Cys Asp Ile His Val Xaa Trp Glu Trp Glu Cys Phe Glu Arg Leu 
1               5                   10                  15      


<210>  102
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  102

Val Asp Asn Phe Lys Asn Lys Glu Gln Gln Asn Ala Phe Tyr Glu Ile 
1               5                   10                  15      


Leu His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Ala Phe Ile Gln 
            20                  25                  30          


Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala 
        35                  40                  45              


Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys 
    50                  55              


<210>  103
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Beta-3 Asp

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Beta-3 Phe

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  2-aminocyclopentanecarboxylic acid

<220>
<221>  DISULFID
<222>  (9)..(38)

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (33)..(33)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  2-aminocyclopentanecarboxylic acid

<400>  103

Val Xaa Asn Lys Xaa Asn Lys Xaa Cys Gln Xaa Arg Phe Tyr Glu Xaa 
1               5                   10                  15      


Leu His Asp Pro Asn Leu Asn Glu Glu Gln Arg Asn Xaa Lys Ile Gln 
            20                  25                  30          


Xaa Ile Lys Xaa Asp Cys 
        35              


<210>  104
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Beta-3 Asp

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Beta-3 Phe

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  2-aminocyclopentanecarboxylic acid

<220>
<221>  DISULFID
<222>  (9)..(38)

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (33)..(33)
<223>  3-aminopyrrolidine-4-carboxylic acid

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  2-aminocyclopentanecarboxylic acid

<400>  104

Val Xaa Asn Lys Xaa Asn Lys Xaa Cys Gln Asn Arg Phe Tyr Glu Xaa 
1               5                   10                  15      


Leu His Asp Pro Asn Leu Asn Glu Glu Gln Arg Asn Xaa Lys Ile Gln 
            20                  25                  30          


Xaa Ile Lys Xaa Asp Cys 
        35              


<210>  105
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide


<220>
<221>  DISULFID
<222>  (5)..(34)

<400>  105

Phe Asn Met Gln Cys Gln Arg Arg Phe Tyr Ala Glu Leu His Asp Pro 
1               5                   10                  15      


Asn Leu Asn Glu Glu Gln Arg Asn Ala Lys Ile Lys Ser Ile Arg Asp 
            20                  25                  30          


Asp Cys 
        


<210>  106
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized, unnatural polypeptide

<400>  106

Val Asp Asn Lys Phe Asn Lys Glu Met His Asn Ala Tyr Ala Ile Glu 
1               5                   10                  15      


Ile Ala Leu Leu Pro Asn Leu Asn Asp Gln Gln Phe His Ala Phe Ile 
            20                  25                  30          


Trp Ser Leu Ile Asp Asp Pro 
        35                  


