                         SEQUENCE LISTING

<110>  MEDIMMUNE LLC
 
<120>  COMPOSITIONS AND METHODS FOR MODULATING AND REDIRECTING IMMUNE 
       RESPONSES

<130>  CEABT-210P1

<140>  To Be Assigned
<141>  Herewith

<160>  121   

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  1

Asp Arg Gly Leu Arg Phe Tyr Phe Asp Tyr 
1               5                   10  


<210>  2
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  2

Phe Ile Leu Asn Lys Ala Asn Gly Gly Thr Thr Glu Tyr Ala Ala Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  3
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic A240 VL bispecific single chain antibody polypeptide

<400>  3

Gln Ala Val Leu Thr Gln Pro Ala Ser Leu Ser Ala Ser Pro Gly Ala 
1               5                   10                  15      


Ser Ala Ser Leu Thr Cys Thr Leu Arg Arg Gly Ile Asn Val Gly Ala 
            20                  25                  30          


Tyr Ser Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr 
        35                  40                  45              


Leu Leu Arg Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val 
    50                  55                  60                  


Ser Ser Arg Phe Ser Ala Ser Lys Asp Ala Ser Ala Asn Ala Gly Ile 
65                  70                  75                  80  


Leu Leu Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Met Ile Trp His Ser Gly Ala Ser Ala Val Phe Gly Gly Gly Thr Lys 
            100                 105                 110         


Leu Thr Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val 
145                 150                 155                 160 


Ser Ser Tyr Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                165                 170                 175     


Glu Trp Val Gly Phe Ile Arg Asn Lys Ala Asn Gly Gly Thr Thr Glu 
            180                 185                 190         


Tyr Ala Ala Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser 
        195                 200                 205             


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Ala Arg Asp Arg Gly Leu Arg Phe Tyr Phe Asp 
225                 230                 235                 240 


Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Asp Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
            260                 265                 270         


Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
        275                 280                 285             


Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 
    290                 295                 300                 


Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Ala Asp 
305                 310                 315                 320 


Ser Val Lys Gly Arg Phe Thr Ile Thr Thr Asp Lys Ser Thr Ser Thr 
                325                 330                 335     


Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr 
            340                 345                 350         


Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly 
        355                 360                 365             


Gln Gly Thr Thr Val Thr Val Ser Ser Gly Glu Gly Thr Ser Thr Gly 
    370                 375                 380                 


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ala Asp Asp Ile Val Leu Thr 
385                 390                 395                 400 


Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
                405                 410                 415     


Ser Cys Arg Ala Ser Gln Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln 
            420                 425                 430         


Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val 
        435                 440                 445             


Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    450                 455                 460                 


Tyr Ser Leu Thr Ile Asn Ser Leu Glu Ala Glu Asp Ala Ala Thr Tyr 
465                 470                 475                 480 


Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Gly Gly Thr 
                485                 490                 495     


Lys Val Glu Ile Lys 
            500     


<210>  4
<211>  702
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Glu Ser Pro Ser Ala Pro Pro His Arg Trp Cys Ile Pro Trp Gln 
1               5                   10                  15      


Arg Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile 
65                  70                  75                  80  


Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile 
            100                 105                 110         


Ile Gln Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Ala Thr Tyr 
                165                 170                 175     


Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn 
        195                 200                 205             


Asp Thr Ala Ser Tyr Lys Cys Glu Thr Gln Asn Pro Val Ser Ala Arg 
    210                 215                 220                 


Arg Ser Asp Ser Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Leu Asn Thr Ser Tyr Arg Ser Gly Glu Asn Leu Asn 
                245                 250                 255     


Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe 
            260                 265                 270         


Val Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys Gln Ala His Asn Ser 
    290                 295                 300                 


Asp Thr Gly Leu Asn Arg Thr Thr Val Thr Thr Ile Thr Val Tyr Ala 
305                 310                 315                 320 


Glu Pro Pro Lys Pro Phe Ile Thr Ser Asn Asn Ser Asn Pro Val Glu 
                325                 330                 335     


Asp Glu Asp Ala Val Ala Leu Thr Cys Glu Pro Glu Ile Gln Asn Thr 
            340                 345                 350         


Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg 
        355                 360                 365             


Leu Gln Leu Ser Asn Asp Asn Arg Thr Leu Thr Leu Leu Ser Val Thr 
    370                 375                 380                 


Arg Asn Asp Val Gly Pro Tyr Glu Cys Gly Ile Gln Asn Lys Leu Ser 
385                 390                 395                 400 


Val Asp His Ser Asp Pro Val Ile Leu Asn Val Leu Tyr Gly Pro Asp 
                405                 410                 415     


Asp Pro Thr Ile Ser Pro Ser Tyr Thr Tyr Tyr Arg Pro Gly Val Asn 
            420                 425                 430         


Leu Ser Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser 
        435                 440                 445             


Trp Leu Ile Asp Gly Asn Ile Gln Gln His Thr Gln Glu Leu Phe Ile 
    450                 455                 460                 


Ser Asn Ile Thr Glu Lys Asn Ser Gly Leu Tyr Thr Cys Gln Ala Asn 
465                 470                 475                 480 


Asn Ser Ala Ser Gly His Ser Arg Thr Thr Val Lys Thr Ile Thr Val 
                485                 490                 495     


Ser Ala Glu Leu Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro 
            500                 505                 510         


Val Glu Asp Lys Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Ala Gln 
        515                 520                 525             


Asn Thr Thr Tyr Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser 
    530                 535                 540                 


Pro Arg Leu Gln Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn 
545                 550                 555                 560 


Val Thr Arg Asn Asp Ala Arg Ala Tyr Val Cys Gly Ile Gln Asn Ser 
                565                 570                 575     


Val Ser Ala Asn Arg Ser Asp Pro Val Thr Leu Asp Val Leu Tyr Gly 
            580                 585                 590         


Pro Asp Thr Pro Ile Ile Ser Pro Pro Asp Ser Ser Tyr Leu Ser Gly 
        595                 600                 605             


Ala Asn Leu Asn Leu Ser Cys His Ser Ala Ser Asn Pro Ser Pro Gln 
    610                 615                 620                 


Tyr Ser Trp Arg Ile Asn Gly Ile Pro Gln Gln His Thr Gln Val Leu 
625                 630                 635                 640 


Phe Ile Ala Lys Ile Thr Pro Asn Asn Asn Gly Thr Tyr Ala Cys Phe 
                645                 650                 655     


Val Ser Asn Leu Ala Thr Gly Arg Asn Asn Ser Ile Val Lys Ser Ile 
            660                 665                 670         


Thr Val Ser Ala Ser Gly Thr Ser Pro Gly Leu Ser Ala Gly Ala Thr 
        675                 680                 685             


Val Gly Ile Met Ile Gly Val Leu Val Gly Val Ala Leu Ile 
    690                 695                 700         


<210>  5
<211>  524
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Glu Ser Pro Ser Ala Pro Pro His Arg Trp Cys Ile Pro Trp Gln 
1               5                   10                  15      


Arg Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile 
65                  70                  75                  80  


Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile 
            100                 105                 110         


Ile Gln Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Ala Thr Tyr 
                165                 170                 175     


Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn 
        195                 200                 205             


Asp Thr Ala Ser Tyr Lys Cys Glu Thr Gln Asn Pro Val Ser Ala Arg 
    210                 215                 220                 


Arg Ser Asp Ser Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Leu Asn Thr Ser Tyr Arg Ser Gly Glu Asn Leu Asn 
                245                 250                 255     


Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe 
            260                 265                 270         


Val Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys Gln Ala His Asn Ser 
    290                 295                 300                 


Asp Thr Gly Leu Asn Arg Thr Thr Val Thr Thr Ile Thr Val Tyr Ala 
305                 310                 315                 320 


Glu Pro Pro Lys Pro Phe Ile Thr Ser Asn Asn Ser Asn Pro Val Glu 
                325                 330                 335     


Asp Glu Asp Ala Val Ala Leu Thr Cys Glu Pro Glu Ile Gln Asn Thr 
            340                 345                 350         


Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg 
        355                 360                 365             


Leu Gln Leu Ser Asn Asp Asn Arg Thr Leu Thr Leu Leu Ser Val Thr 
    370                 375                 380                 


Arg Asn Asp Val Gly Pro Tyr Glu Cys Gly Ile Gln Asn Glu Leu Ser 
385                 390                 395                 400 


Val Asp His Ser Asp Pro Val Ile Leu Asn Val Leu Tyr Gly Pro Asp 
                405                 410                 415     


Asp Pro Thr Ile Ser Pro Ser Tyr Thr Tyr Tyr Arg Pro Gly Val Asn 
            420                 425                 430         


Leu Ser Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser 
        435                 440                 445             


Trp Leu Ile Asp Gly Asn Ile Gln Gln His Thr Gln Glu Leu Phe Ile 
    450                 455                 460                 


Ser Asn Ile Thr Glu Lys Asn Ser Gly Leu Tyr Thr Cys Gln Ala Asn 
465                 470                 475                 480 


Asn Ser Ala Ser Gly His Ser Arg Thr Thr Val Lys Thr Ile Thr Val 
                485                 490                 495     


Ser Ala Ser Gly Thr Ser Pro Gly Leu Ser Ala Gly Ala Thr Val Gly 
            500                 505                 510         


Ile Met Ile Gly Val Leu Val Gly Val Ala Leu Ile 
        515                 520                 


<210>  6
<211>  524
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Glu Ser Pro Ser Ala Pro Pro His Arg Trp Cys Ile Pro Trp Gln 
1               5                   10                  15      


Arg Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile 
65                  70                  75                  80  


Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile 
            100                 105                 110         


Ile Gln Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Ala Thr Tyr 
                165                 170                 175     


Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn 
        195                 200                 205             


Asp Thr Ala Ser Tyr Lys Cys Glu Thr Gln Asn Pro Val Ser Ala Arg 
    210                 215                 220                 


Arg Ser Asp Ser Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Asp Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Ser Tyr Thr Tyr Tyr Arg Pro Gly Val Asn Leu Ser 
                245                 250                 255     


Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu 
            260                 265                 270         


Ile Asp Gly Asn Ile Gln Gln His Thr Gln Glu Leu Phe Ile Ser Asn 
        275                 280                 285             


Ile Thr Glu Lys Asn Ser Gly Leu Tyr Thr Cys Gln Ala Asn Asn Ser 
    290                 295                 300                 


Ala Ser Gly His Ser Arg Thr Thr Val Lys Thr Ile Thr Val Ser Ala 
305                 310                 315                 320 


Glu Leu Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val Glu 
                325                 330                 335     


Asp Lys Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Ala Gln Asn Thr 
            340                 345                 350         


Thr Tyr Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg 
        355                 360                 365             


Leu Gln Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val Thr 
    370                 375                 380                 


Arg Asn Asp Ala Arg Ala Tyr Val Cys Gly Ile Gln Asn Ser Val Ser 
385                 390                 395                 400 


Ala Asn Arg Ser Asp Pro Val Thr Leu Asp Val Leu Tyr Gly Pro Asp 
                405                 410                 415     


Thr Pro Ile Ile Ser Pro Pro Asp Ser Ser Tyr Leu Ser Gly Ala Asn 
            420                 425                 430         


Leu Asn Leu Ser Cys His Ser Ala Ser Asn Pro Ser Pro Gln Tyr Ser 
        435                 440                 445             


Trp Arg Ile Asn Gly Ile Pro Gln Gln His Thr Gln Val Leu Phe Ile 
    450                 455                 460                 


Ala Lys Ile Thr Pro Asn Asn Asn Gly Thr Tyr Ala Cys Phe Val Ser 
465                 470                 475                 480 


Asn Leu Ala Thr Gly Arg Asn Asn Ser Ile Val Lys Ser Ile Thr Val 
                485                 490                 495     


Ser Ala Ser Gly Thr Ser Pro Gly Leu Ser Ala Gly Ala Thr Val Gly 
            500                 505                 510         


Ile Met Ile Gly Val Leu Val Gly Val Ala Leu Ile 
        515                 520                 


<210>  7
<211>  420
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Glu Ser Pro Ser Ala Pro Pro His Arg Trp Cys Ile Pro Trp Gln 
1               5                   10                  15      


Arg Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile 
65                  70                  75                  80  


Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile 
            100                 105                 110         


Ile Gln Asn Glu Leu Ser Val Asp His Ser Asp Pro Val Ile Leu Asn 
        115                 120                 125             


Val Leu Tyr Gly Pro Asp Asp Pro Thr Ile Ser Pro Ser Tyr Thr Tyr 
    130                 135                 140                 


Tyr Arg Pro Gly Val Asn Leu Ser Leu Ser Cys His Ala Ala Ser Asn 
145                 150                 155                 160 


Pro Pro Ala Gln Tyr Ser Trp Leu Ile Asp Gly Asn Ile Gln Gln His 
                165                 170                 175     


Thr Gln Glu Leu Phe Ile Ser Asn Ile Thr Glu Lys Asn Ser Gly Leu 
            180                 185                 190         


Tyr Thr Cys Gln Ala Asn Asn Ser Ala Ser Gly His Ser Arg Thr Thr 
        195                 200                 205             


Val Lys Thr Ile Thr Val Ser Ala Glu Leu Pro Lys Pro Ser Ile Ser 
    210                 215                 220                 


Ser Asn Asn Ser Lys Pro Val Glu Asp Lys Asp Ala Val Ala Phe Thr 
225                 230                 235                 240 


Cys Glu Pro Glu Ala Gln Asn Thr Thr Tyr Leu Trp Trp Val Asn Gly 
                245                 250                 255     


Gln Ser Leu Pro Val Ser Pro Arg Leu Gln Leu Ser Asn Gly Asn Arg 
            260                 265                 270         


Thr Leu Thr Leu Phe Asn Val Thr Arg Asn Asp Ala Arg Ala Tyr Val 
        275                 280                 285             


Cys Gly Ile Gln Asn Ser Val Ser Ala Asn Arg Ser Asp Pro Val Thr 
    290                 295                 300                 


Leu Asp Val Leu Tyr Gly Pro Asp Thr Pro Ile Ile Ser Pro Pro Asp 
305                 310                 315                 320 


Ser Ser Tyr Leu Ser Gly Ala Asn Leu Asn Leu Ser Cys His Ser Ala 
                325                 330                 335     


Ser Asn Pro Ser Pro Gln Tyr Ser Trp Arg Ile Asn Gly Ile Pro Gln 
            340                 345                 350         


Gln His Thr Gln Val Leu Phe Ile Ala Lys Ile Thr Pro Asn Asn Asn 
        355                 360                 365             


Gly Thr Tyr Ala Cys Phe Val Ser Asn Leu Ala Thr Gly Arg Asn Asn 
    370                 375                 380                 


Ser Ile Val Lys Ser Ile Thr Val Ser Ala Ser Gly Thr Ser Pro Gly 
385                 390                 395                 400 


Leu Ser Ala Gly Ala Thr Val Gly Ile Met Ile Gly Val Leu Val Gly 
                405                 410                 415     


Val Ala Leu Ile 
            420 


<210>  8
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  8

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Arg Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Asp Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Leu Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  9
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  9

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Gly Trp Phe Gly Glu Leu Ala Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  10
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  10

Arg Tyr Trp Met Ser 
1               5   


<210>  11
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  11

Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  12
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  12

Glu Gly Gly Trp Phe Gly Glu Leu Ala Phe Asp Tyr 
1               5                   10          


<210>  13
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  13

Arg Ala Ser Gln Arg Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  14
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  14

Asp Ala Ser Ser Arg Ala Thr 
1               5           


<210>  15
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  15

Gln Gln Tyr Gly Ser Leu Pro Trp Thr 
1               5                   


<210>  16
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bispecific single chain antibody

<400>  16

Gln Ala Val Leu Thr Gln Pro Ala Ser Leu Ser Ala Ser Pro Gly Ala 
1               5                   10                  15      


Ser Ala Ser Leu Thr Cys Thr Leu Arg Arg Gly Ile Asn Val Gly Ala 
            20                  25                  30          


Tyr Ser Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr 
        35                  40                  45              


Leu Leu Arg Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val 
    50                  55                  60                  


Ser Ser Arg Phe Ser Ala Ser Lys Asp Ala Ser Ala Asn Ala Gly Ile 
65                  70                  75                  80  


Leu Leu Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Met Ile Trp His Ser Gly Ala Ser Ala Val Phe Gly Gly Gly Thr Lys 
            100                 105                 110         


Leu Thr Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val 
145                 150                 155                 160 


Ser Ser Tyr Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                165                 170                 175     


Glu Trp Val Gly Phe Ile Arg Asn Lys Ala Asn Gly Gly Thr Thr Glu 
            180                 185                 190         


Tyr Ala Ala Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser 
        195                 200                 205             


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Ala Arg Asp Arg Gly Leu Arg Phe Tyr Phe Asp 
225                 230                 235                 240 


Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Asp Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
            260                 265                 270         


Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg 
        275                 280                 285             


Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
    290                 295                 300                 


Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Ala Asp Ser 
305                 310                 315                 320 


Val Lys Gly Arg Phe Thr Ile Thr Thr Asp Lys Ser Thr Ser Thr Ala 
                325                 330                 335     


Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr 
            340                 345                 350         


Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln 
        355                 360                 365             


Gly Thr Thr Val Thr Val Ser Ser Gly Glu Gly Thr Ser Thr Gly Ser 
    370                 375                 380                 


Gly Gly Ser Gly Gly Ser Gly Gly Ala Asp Asp Ile Val Leu Thr Gln 
385                 390                 395                 400 


Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 
                405                 410                 415     


Cys Arg Ala Ser Gln Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys 
            420                 425                 430         


Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val Ala 
        435                 440                 445             


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
    450                 455                 460                 


Ser Leu Thr Ile Asn Ser Leu Glu Ala Glu Asp Ala Ala Thr Tyr Tyr 
465                 470                 475                 480 


Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys 
                485                 490                 495     


Val Glu Ile Lys 
            500 


<210>  17
<211>  10
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  CDR-H3* A5B7 Shorter CDR-3 of VH of A5B7 with D corresponding to 
       Kabat position 95; Kabat positions 100, 100a, 100b, 101, 102 
       correspond to FYFDY, respectively

<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  with "X1", "X2", "X3" and "X4" corresponding to Kabat positions 
       96 ("X1"), 97 ("X2"), 98 ("X3") and 99 ("X4"), respectively, of 
       CDR-H3 of murine monoclonal antibody A5B7 and wherein "X" 
       represents any amino acid residue. "X1" is preferably "R"

<220>
<221>  misc_feature
<222>  (2)..(5)
<223>  Xaa can be any naturally occurring amino acid

<400>  17

Asp Xaa Xaa Xaa Xaa Phe Tyr Phe Asp Tyr 
1               5                   10  


<210>  18
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  18

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Thr Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Ser Asn Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Gly Leu Arg Phe Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  19
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  19

Gln Ala Val Leu Thr Gln Pro Ala Ser Leu Ser Ala Ser Pro Gly Ala 
1               5                   10                  15      


Ser Ala Ser Leu Thr Cys Thr Leu Arg Arg Gly Ile Asn Val Gly Ala 
            20                  25                  30          


Tyr Ser Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr 
        35                  40                  45              


Leu Leu Arg Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val 
    50                  55                  60                  


Ser Ser Arg Phe Ser Ala Ser Lys Asp Ala Ser Ala Asn Ala Gly Ile 
65                  70                  75                  80  


Leu Leu Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Met Ile Trp His Ser Gly Ala Ser Ala Val Phe Gly Gly Gly Thr Lys 
            100                 105                 110         


Leu Thr Val Leu 
        115     


<210>  20
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  20

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Thr Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Ser Asn Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Gly Leu Arg Phe Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gln Ala Val Leu Thr Gln Pro Ala Ser Leu 
    130                 135                 140                 


Ser Ala Ser Pro Gly Ala Ser Ala Ser Leu Thr Cys Thr Leu Arg Arg 
145                 150                 155                 160 


Gly Ile Asn Val Gly Ala Tyr Ser Ile Tyr Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Ser Pro Pro Gln Tyr Leu Leu Arg Tyr Lys Ser Asp Ser Asp Lys 
            180                 185                 190         


Gln Gln Gly Ser Gly Val Ser Ser Arg Phe Ser Ala Ser Lys Asp Ala 
        195                 200                 205             


Ser Ala Asn Ala Gly Ile Leu Leu Ile Ser Gly Leu Gln Ser Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Met Ile Trp His Ser Gly Ala Ser Ala Val 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 250 


<210>  21
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  21

Gln Ala Val Leu Thr Gln Pro Ala Ser Leu Ser Ala Ser Pro Gly Ala 
1               5                   10                  15      


Ser Ala Ser Leu Thr Cys Thr Leu Arg Arg Gly Ile Asn Val Gly Ala 
            20                  25                  30          


Tyr Ser Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr 
        35                  40                  45              


Leu Leu Arg Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val 
    50                  55                  60                  


Ser Ser Arg Phe Ser Ala Ser Lys Asp Ala Ser Ala Asn Ala Gly Ile 
65                  70                  75                  80  


Leu Leu Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Met Ile Trp His Ser Gly Ala Ser Ala Val Phe Gly Gly Gly Thr Lys 
            100                 105                 110         


Leu Thr Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln 
    130                 135                 140                 


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu 
145                 150                 155                 160 


Ser Thr Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                165                 170                 175     


Glu Trp Val Ala Leu Ile Ser Asn Asp Gly Ser Asn Lys Tyr Tyr Ala 
            180                 185                 190         


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
        195                 200                 205             


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Asp Arg Gly Leu Arg Phe Tyr Phe Asp Tyr Trp 
225                 230                 235                 240 


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
                245                 250 


<210>  22
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  22

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Thr Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Ser Asn Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Asp Arg Gly Leu Arg Phe Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  23
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  23

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Thr Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Ser Asn Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Asp Arg Gly Leu Arg Phe Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gln Ala Val Leu Thr Gln Pro Ala Ser Leu 
    130                 135                 140                 


Ser Ala Ser Pro Gly Ala Ser Ala Ser Leu Thr Cys Thr Leu Arg Arg 
145                 150                 155                 160 


Gly Ile Asn Val Gly Ala Tyr Ser Ile Tyr Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Ser Pro Pro Gln Tyr Leu Leu Arg Tyr Lys Ser Asp Ser Asp Lys 
            180                 185                 190         


Gln Gln Gly Ser Gly Val Ser Ser Arg Phe Ser Ala Ser Lys Asp Ala 
        195                 200                 205             


Ser Ala Asn Ala Gly Ile Leu Leu Ile Ser Gly Leu Gln Ser Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Met Ile Trp His Ser Gly Ala Ser Ala Val 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 250 


<210>  24
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  24

Gln Ala Val Leu Thr Gln Pro Ala Ser Leu Ser Ala Ser Pro Gly Ala 
1               5                   10                  15      


Ser Ala Ser Leu Thr Cys Thr Leu Arg Arg Gly Ile Asn Val Gly Ala 
            20                  25                  30          


Tyr Ser Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr 
        35                  40                  45              


Leu Leu Arg Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val 
    50                  55                  60                  


Ser Ser Arg Phe Ser Ala Ser Lys Asp Ala Ser Ala Asn Ala Gly Ile 
65                  70                  75                  80  


Leu Leu Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Met Ile Trp His Ser Gly Ala Ser Ala Val Phe Gly Gly Gly Thr Lys 
            100                 105                 110         


Leu Thr Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln 
    130                 135                 140                 


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu 
145                 150                 155                 160 


Ser Thr Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                165                 170                 175     


Glu Trp Val Ala Leu Ile Ser Asn Asp Gly Ser Asn Lys Tyr Tyr Ala 
            180                 185                 190         


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
        195                 200                 205             


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Thr Arg Asp Arg Gly Leu Arg Phe Tyr Phe Asp Tyr Trp 
225                 230                 235                 240 


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
                245                 250 


<210>  25
<211>  121
<212>  PRT
<213>  Mus musculus

<400>  25

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu 
        35                  40                  45              


Gly Phe Ile Gly Asn Lys Ala Asn Gly Tyr Thr Thr Glu Tyr Ser Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ser Gln Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Thr Leu Arg Ala Glu Asp Ser Ala Thr Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Asp Arg Gly Leu Arg Phe Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  26
<211>  252
<212>  PRT
<213>  Artificial sequence

<220>
<223>  A5B7 VH - A240 VL ; Single chain Fv

<400>  26

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu 
        35                  40                  45              


Gly Phe Ile Gly Asn Lys Ala Asn Gly Tyr Thr Thr Glu Tyr Ser Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ser Gln Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Thr Leu Arg Ala Glu Asp Ser Ala Thr Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Asp Arg Gly Leu Arg Phe Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Leu Thr Gln Pro Ala 
    130                 135                 140                 


Ser Leu Ser Ala Ser Pro Gly Ala Ser Ala Ser Leu Thr Cys Thr Leu 
145                 150                 155                 160 


Arg Arg Gly Ile Asn Val Gly Ala Tyr Ser Ile Tyr Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Ser Pro Pro Gln Tyr Leu Leu Arg Tyr Lys Ser Asp Ser 
            180                 185                 190         


Asp Lys Gln Gln Gly Ser Gly Val Ser Ser Arg Phe Ser Ala Ser Lys 
        195                 200                 205             


Asp Ala Ser Ala Asn Ala Gly Ile Leu Leu Ile Ser Gly Leu Gln Ser 
    210                 215                 220                 


Glu Asp Glu Ala Asp Tyr Tyr Cys Met Ile Trp His Ser Gly Ala Ser 
225                 230                 235                 240 


Ala Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 250         


<210>  27
<211>  252
<212>  PRT
<213>  Artificial sequence

<220>
<223>  A240 VL -A5B7 VH ; single chain Fv

<400>  27

Gln Ala Val Leu Thr Gln Pro Ala Ser Leu Ser Ala Ser Pro Gly Ala 
1               5                   10                  15      


Ser Ala Ser Leu Thr Cys Thr Leu Arg Arg Gly Ile Asn Val Gly Ala 
            20                  25                  30          


Tyr Ser Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr 
        35                  40                  45              


Leu Leu Arg Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val 
    50                  55                  60                  


Ser Ser Arg Phe Ser Ala Ser Lys Asp Ala Ser Ala Asn Ala Gly Ile 
65                  70                  75                  80  


Leu Leu Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Met Ile Trp His Ser Gly Ala Ser Ala Val Phe Gly Gly Gly Thr Lys 
            100                 105                 110         


Leu Thr Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe 
145                 150                 155                 160 


Thr Asp Tyr Tyr Met Asn Trp Val Arg Gln Pro Pro Gly Lys Ala Leu 
                165                 170                 175     


Glu Trp Leu Gly Phe Ile Gly Asn Lys Ala Asn Gly Tyr Thr Thr Glu 
            180                 185                 190         


Tyr Ser Ala Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ser 
        195                 200                 205             


Gln Ser Ile Leu Tyr Leu Gln Met Asn Thr Leu Arg Ala Glu Asp Ser 
    210                 215                 220                 


Ala Thr Tyr Tyr Cys Thr Arg Asp Arg Gly Leu Arg Phe Tyr Phe Asp 
225                 230                 235                 240 


Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
                245                 250         


<210>  28
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  28

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Phe Ile Arg Asn Lys Ala Asn Gly Gly Thr Thr Glu Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Arg Gly Leu Arg Phe Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  29
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  29

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Phe Ile Leu Asn Lys Ala Asn Gly Gly Thr Thr Glu Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Arg Gly Leu Arg Phe Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  30
<211>  490
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Bispecific single chain antibody

<400>  30

Asp Ile Glu Leu Thr Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Thr Tyr Ile 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Ser Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln His Trp Ser Ser Lys Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser 
        115                 120                 125             


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
    130                 135                 140                 


Thr Ser Gly Phe Thr Phe Thr Asp Tyr Tyr Met Asn Trp Val Arg Gln 
145                 150                 155                 160 


Pro Pro Gly Lys Ala Leu Glu Trp Leu Gly Phe Ile Gly Asn Lys Ala 
                165                 170                 175     


Asn Gly Tyr Thr Thr Glu Tyr Ser Ala Ser Val Lys Gly Arg Phe Thr 
            180                 185                 190         


Ile Ser Arg Asp Lys Ser Gln Ser Ile Leu Tyr Leu Gln Met Asn Thr 
        195                 200                 205             


Leu Arg Ala Glu Asp Ser Ala Thr Tyr Tyr Cys Thr Arg Asp Arg Gly 
    210                 215                 220                 


Leu Arg Phe Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
225                 230                 235                 240 


Ser Ser Gly Gly Gly Gly Ser Asp Val Gln Leu Val Gln Ser Gly Ala 
                245                 250                 255     


Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser 
            260                 265                 270         


Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro 
        275                 280                 285             


Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr 
    290                 295                 300                 


Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Thr Thr Asp 
305                 310                 315                 320 


Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu 
                325                 330                 335     


Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys 
            340                 345                 350         


Leu Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Glu 
        355                 360                 365             


Gly Thr Ser Thr Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ala Asp 
    370                 375                 380                 


Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
385                 390                 395                 400 


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Tyr Met 
                405                 410                 415     


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
            420                 425                 430         


Asp Thr Ser Lys Val Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
        435                 440                 445             


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Asn Ser Leu Glu Ala Glu 
    450                 455                 460                 


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
465                 470                 475                 480 


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                485                 490 


<210>  31
<211>  491
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Bispecific single chain antibody

<400>  31

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu 
        35                  40                  45              


Gly Phe Ile Gly Asn Lys Ala Asn Gly Tyr Thr Thr Glu Tyr Ser Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ser Gln Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Thr Leu Arg Ala Glu Asp Ser Ala Thr Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Asp Arg Gly Leu Arg Phe Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Ser Ser Val Thr Tyr Ile His Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Ser Ser Pro Lys Ser Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly 
            180                 185                 190         


Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu 
        195                 200                 205             


Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


His Trp Ser Ser Lys Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Lys Ser Gly Gly Gly Gly Ser Asp Val Gln Leu Val Gln Ser Gly 
                245                 250                 255     


Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala 
            260                 265                 270         


Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala 
        275                 280                 285             


Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly 
    290                 295                 300                 


Tyr Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Thr Thr 
305                 310                 315                 320 


Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
                325                 330                 335     


Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr 
            340                 345                 350         


Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly 
        355                 360                 365             


Glu Gly Thr Ser Thr Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ala 
    370                 375                 380                 


Asp Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro 
385                 390                 395                 400 


Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Tyr 
                405                 410                 415     


Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile 
            420                 425                 430         


Tyr Asp Thr Ser Lys Val Ala Ser Gly Val Pro Ala Arg Phe Ser Gly 
        435                 440                 445             


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Asn Ser Leu Glu Ala 
    450                 455                 460                 


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu 
465                 470                 475                 480 


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                485                 490     


<210>  32
<211>  501
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Bispecific single chain antibody

<400>  32

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu 
        35                  40                  45              


Gly Phe Ile Gly Asn Lys Ala Asn Gly Tyr Thr Thr Glu Tyr Ser Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ser Gln Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Thr Leu Arg Ala Glu Asp Ser Ala Thr Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Asp Arg Gly Leu Arg Phe Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Leu Thr Gln Pro Ala 
    130                 135                 140                 


Ser Leu Ser Ala Ser Pro Gly Ala Ser Ala Ser Leu Thr Cys Thr Leu 
145                 150                 155                 160 


Arg Arg Gly Ile Asn Val Gly Ala Tyr Ser Ile Tyr Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Ser Pro Pro Gln Tyr Leu Leu Arg Tyr Lys Ser Asp Ser 
            180                 185                 190         


Asp Lys Gln Gln Gly Ser Gly Val Ser Ser Arg Phe Ser Ala Ser Lys 
        195                 200                 205             


Asp Ala Ser Ala Asn Ala Gly Ile Leu Leu Ile Ser Gly Leu Gln Ser 
    210                 215                 220                 


Glu Asp Glu Ala Asp Tyr Tyr Cys Met Ile Trp His Ser Gly Ala Ser 
225                 230                 235                 240 


Ala Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Asp Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
            260                 265                 270         


Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
        275                 280                 285             


Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 
    290                 295                 300                 


Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Ala Asp 
305                 310                 315                 320 


Ser Val Lys Gly Arg Phe Thr Ile Thr Thr Asp Lys Ser Thr Ser Thr 
                325                 330                 335     


Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr 
            340                 345                 350         


Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly 
        355                 360                 365             


Gln Gly Thr Thr Val Thr Val Ser Ser Gly Glu Gly Thr Ser Thr Gly 
    370                 375                 380                 


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ala Asp Asp Ile Val Leu Thr 
385                 390                 395                 400 


Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
                405                 410                 415     


Ser Cys Arg Ala Ser Gln Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln 
            420                 425                 430         


Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val 
        435                 440                 445             


Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    450                 455                 460                 


Tyr Ser Leu Thr Ile Asn Ser Leu Glu Ala Glu Asp Ala Ala Thr Tyr 
465                 470                 475                 480 


Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Gly Gly Thr 
                485                 490                 495     


Lys Val Glu Ile Lys 
            500     


<210>  33
<211>  500
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Bispecific single chain antibody

<400>  33

Gln Ala Val Leu Thr Gln Pro Ala Ser Leu Ser Ala Ser Pro Gly Ala 
1               5                   10                  15      


Ser Ala Ser Leu Thr Cys Thr Leu Arg Arg Gly Ile Asn Val Gly Ala 
            20                  25                  30          


Tyr Ser Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr 
        35                  40                  45              


Leu Leu Arg Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val 
    50                  55                  60                  


Ser Ser Arg Phe Ser Ala Ser Lys Asp Ala Ser Ala Asn Ala Gly Ile 
65                  70                  75                  80  


Leu Leu Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Met Ile Trp His Ser Gly Ala Ser Ala Val Phe Gly Gly Gly Thr Lys 
            100                 105                 110         


Leu Thr Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe 
145                 150                 155                 160 


Thr Asp Tyr Tyr Met Asn Trp Val Arg Gln Pro Pro Gly Lys Ala Leu 
                165                 170                 175     


Glu Trp Leu Gly Phe Ile Gly Asn Lys Ala Asn Gly Tyr Thr Thr Glu 
            180                 185                 190         


Tyr Ser Ala Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ser 
        195                 200                 205             


Gln Ser Ile Leu Tyr Leu Gln Met Asn Thr Leu Arg Ala Glu Asp Ser 
    210                 215                 220                 


Ala Thr Tyr Tyr Cys Thr Arg Asp Arg Gly Leu Arg Phe Tyr Phe Asp 
225                 230                 235                 240 


Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Asp Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
            260                 265                 270         


Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg 
        275                 280                 285             


Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
    290                 295                 300                 


Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Ala Asp Ser 
305                 310                 315                 320 


Val Lys Gly Arg Phe Thr Ile Thr Thr Asp Lys Ser Thr Ser Thr Ala 
                325                 330                 335     


Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr 
            340                 345                 350         


Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln 
        355                 360                 365             


Gly Thr Thr Val Thr Val Ser Ser Gly Glu Gly Thr Ser Thr Gly Ser 
    370                 375                 380                 


Gly Gly Ser Gly Gly Ser Gly Gly Ala Asp Asp Ile Val Leu Thr Gln 
385                 390                 395                 400 


Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 
                405                 410                 415     


Cys Arg Ala Ser Gln Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys 
            420                 425                 430         


Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val Ala 
        435                 440                 445             


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
    450                 455                 460                 


Ser Leu Thr Ile Asn Ser Leu Glu Ala Glu Asp Ala Ala Thr Tyr Tyr 
465                 470                 475                 480 


Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys 
                485                 490                 495     


Val Glu Ile Lys 
            500 


<210>  34
<211>  499
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Bispecific single chain antibody

<400>  34

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Thr Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Ser Asn Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Gly Leu Arg Phe Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Glu Leu Val Leu Thr Gln Pro Ala Ser Leu 
    130                 135                 140                 


Ser Ala Ser Pro Gly Ala Ser Ala Ser Leu Thr Cys Thr Leu Arg Arg 
145                 150                 155                 160 


Gly Ile Asn Val Gly Ala Tyr Ser Ile Tyr Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Ser Pro Pro Gln Tyr Leu Leu Arg Tyr Lys Ser Asp Ser Asp Lys 
            180                 185                 190         


Gln Gln Gly Ser Gly Val Ser Ser Arg Phe Ser Ala Ser Lys Asp Ala 
        195                 200                 205             


Ser Ala Asn Ala Gly Ile Leu Leu Ile Ser Gly Leu Gln Ser Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Met Ile Trp His Ser Gly Ala Ser Ala Val 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Asp Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
            260                 265                 270         


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
        275                 280                 285             


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
    290                 295                 300                 


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Ala Asp Ser Val 
305                 310                 315                 320 


Lys Gly Arg Phe Thr Ile Thr Thr Asp Lys Ser Thr Ser Thr Ala Tyr 
                325                 330                 335     


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
            340                 345                 350         


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
        355                 360                 365             


Thr Thr Val Thr Val Ser Ser Gly Glu Gly Thr Ser Thr Gly Ser Gly 
    370                 375                 380                 


Gly Ser Gly Gly Ser Gly Gly Ala Asp Asp Ile Val Leu Thr Gln Ser 
385                 390                 395                 400 


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
                405                 410                 415     


Arg Ala Ser Gln Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro 
            420                 425                 430         


Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val Ala Ser 
        435                 440                 445             


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser 
    450                 455                 460                 


Leu Thr Ile Asn Ser Leu Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys 
465                 470                 475                 480 


Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
                485                 490                 495     


Glu Ile Lys 
            


<210>  35
<211>  498
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Bispecific single chain antibody

<400>  35

Gln Ala Val Leu Thr Gln Pro Ala Ser Leu Ser Ala Ser Pro Gly Ala 
1               5                   10                  15      


Ser Ala Ser Leu Thr Cys Thr Leu Arg Arg Gly Ile Asn Val Gly Ala 
            20                  25                  30          


Tyr Ser Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr 
        35                  40                  45              


Leu Leu Arg Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val 
    50                  55                  60                  


Ser Ser Arg Phe Ser Ala Ser Lys Asp Ala Ser Ala Asn Ala Gly Ile 
65                  70                  75                  80  


Leu Leu Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Met Ile Trp His Ser Gly Ala Ser Ala Val Phe Gly Gly Gly Thr Lys 
            100                 105                 110         


Leu Thr Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln 
    130                 135                 140                 


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu 
145                 150                 155                 160 


Ser Thr Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                165                 170                 175     


Glu Trp Val Ala Leu Ile Ser Asn Asp Gly Ser Asn Lys Tyr Tyr Ala 
            180                 185                 190         


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
        195                 200                 205             


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Asp Arg Gly Leu Arg Phe Tyr Phe Asp Tyr Trp 
225                 230                 235                 240 


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp 
                245                 250                 255     


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
            260                 265                 270         


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr 
        275                 280                 285             


Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly 
    290                 295                 300                 


Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Ala Asp Ser Val Lys 
305                 310                 315                 320 


Gly Arg Phe Thr Ile Thr Thr Asp Lys Ser Thr Ser Thr Ala Tyr Met 
                325                 330                 335     


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
            340                 345                 350         


Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr 
        355                 360                 365             


Thr Val Thr Val Ser Ser Gly Glu Gly Thr Ser Thr Gly Ser Gly Gly 
    370                 375                 380                 


Ser Gly Gly Ser Gly Gly Ala Asp Asp Ile Val Leu Thr Gln Ser Pro 
385                 390                 395                 400 


Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg 
                405                 410                 415     


Ala Ser Gln Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly 
            420                 425                 430         


Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val Ala Ser Gly 
        435                 440                 445             


Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu 
    450                 455                 460                 


Thr Ile Asn Ser Leu Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln 
465                 470                 475                 480 


Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu 
                485                 490                 495     


Ile Lys 
        


<210>  36
<211>  501
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Bispecific single chain antibody

<400>  36

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Phe Ile Arg Asn Lys Ala Asn Gly Gly Thr Thr Glu Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Arg Gly Leu Arg Phe Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Leu Thr Gln Pro Ala 
    130                 135                 140                 


Ser Leu Ser Ala Ser Pro Gly Ala Ser Ala Ser Leu Thr Cys Thr Leu 
145                 150                 155                 160 


Arg Arg Gly Ile Asn Val Gly Ala Tyr Ser Ile Tyr Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Ser Pro Pro Gln Tyr Leu Leu Arg Tyr Lys Ser Asp Ser 
            180                 185                 190         


Asp Lys Gln Gln Gly Ser Gly Val Ser Ser Arg Phe Ser Ala Ser Lys 
        195                 200                 205             


Asp Ala Ser Ala Asn Ala Gly Ile Leu Leu Ile Ser Gly Leu Gln Ser 
    210                 215                 220                 


Glu Asp Glu Ala Asp Tyr Tyr Cys Met Ile Trp His Ser Gly Ala Ser 
225                 230                 235                 240 


Ala Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Asp Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
            260                 265                 270         


Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
        275                 280                 285             


Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 
    290                 295                 300                 


Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Ala Asp 
305                 310                 315                 320 


Ser Val Lys Gly Arg Phe Thr Ile Thr Thr Asp Lys Ser Thr Ser Thr 
                325                 330                 335     


Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr 
            340                 345                 350         


Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly 
        355                 360                 365             


Gln Gly Thr Thr Val Thr Val Ser Ser Gly Glu Gly Thr Ser Thr Gly 
    370                 375                 380                 


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ala Asp Asp Ile Val Leu Thr 
385                 390                 395                 400 


Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
                405                 410                 415     


Ser Cys Arg Ala Ser Gln Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln 
            420                 425                 430         


Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val 
        435                 440                 445             


Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    450                 455                 460                 


Tyr Ser Leu Thr Ile Asn Ser Leu Glu Ala Glu Asp Ala Ala Thr Tyr 
465                 470                 475                 480 


Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Gly Gly Thr 
                485                 490                 495     


Lys Val Glu Ile Lys 
            500     


<210>  37
<211>  500
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Bispecific single chain antibody

<400>  37

Gln Ala Val Leu Thr Gln Pro Ala Ser Leu Ser Ala Ser Pro Gly Ala 
1               5                   10                  15      


Ser Ala Ser Leu Thr Cys Thr Leu Arg Arg Gly Ile Asn Val Gly Ala 
            20                  25                  30          


Tyr Ser Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr 
        35                  40                  45              


Leu Leu Arg Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val 
    50                  55                  60                  


Ser Ser Arg Phe Ser Ala Ser Lys Asp Ala Ser Ala Asn Ala Gly Ile 
65                  70                  75                  80  


Leu Leu Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Met Ile Trp His Ser Gly Ala Ser Ala Val Phe Gly Gly Gly Thr Lys 
            100                 105                 110         


Leu Thr Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val 
145                 150                 155                 160 


Ser Ser Tyr Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                165                 170                 175     


Glu Trp Val Gly Phe Ile Arg Asn Lys Ala Asn Gly Gly Thr Thr Glu 
            180                 185                 190         


Tyr Ala Ala Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser 
        195                 200                 205             


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Ala Arg Asp Arg Gly Leu Arg Phe Tyr Phe Asp 
225                 230                 235                 240 


Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Asp Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
            260                 265                 270         


Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg 
        275                 280                 285             


Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
    290                 295                 300                 


Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Ala Asp Ser 
305                 310                 315                 320 


Val Lys Gly Arg Phe Thr Ile Thr Thr Asp Lys Ser Thr Ser Thr Ala 
                325                 330                 335     


Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr 
            340                 345                 350         


Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln 
        355                 360                 365             


Gly Thr Thr Val Thr Val Ser Ser Gly Glu Gly Thr Ser Thr Gly Ser 
    370                 375                 380                 


Gly Gly Ser Gly Gly Ser Gly Gly Ala Asp Asp Ile Val Leu Thr Gln 
385                 390                 395                 400 


Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 
                405                 410                 415     


Cys Arg Ala Ser Gln Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys 
            420                 425                 430         


Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val Ala 
        435                 440                 445             


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
    450                 455                 460                 


Ser Leu Thr Ile Asn Ser Leu Glu Ala Glu Asp Ala Ala Thr Tyr Tyr 
465                 470                 475                 480 


Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys 
                485                 490                 495     


Val Glu Ile Lys 
            500 


<210>  38
<211>  499
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Bispecific single chain antibody

<400>  38

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Thr Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Ser Asn Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Asp Arg Gly Leu Arg Phe Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Glu Leu Val Leu Thr Gln Pro Ala Ser Leu 
    130                 135                 140                 


Ser Ala Ser Pro Gly Ala Ser Ala Ser Leu Thr Cys Thr Leu Arg Arg 
145                 150                 155                 160 


Gly Ile Asn Val Gly Ala Tyr Ser Ile Tyr Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Ser Pro Pro Gln Tyr Leu Leu Arg Tyr Lys Ser Asp Ser Asp Lys 
            180                 185                 190         


Gln Gln Gly Ser Gly Val Ser Ser Arg Phe Ser Ala Ser Lys Asp Ala 
        195                 200                 205             


Ser Ala Asn Ala Gly Ile Leu Leu Ile Ser Gly Leu Gln Ser Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Met Ile Trp His Ser Gly Ala Ser Ala Val 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Asp Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
            260                 265                 270         


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
        275                 280                 285             


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
    290                 295                 300                 


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Ala Asp Ser Val 
305                 310                 315                 320 


Lys Gly Arg Phe Thr Ile Thr Thr Asp Lys Ser Thr Ser Thr Ala Tyr 
                325                 330                 335     


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
            340                 345                 350         


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
        355                 360                 365             


Thr Thr Val Thr Val Ser Ser Gly Glu Gly Thr Ser Thr Gly Ser Gly 
    370                 375                 380                 


Gly Ser Gly Gly Ser Gly Gly Ala Asp Asp Ile Val Leu Thr Gln Ser 
385                 390                 395                 400 


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
                405                 410                 415     


Arg Ala Ser Gln Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro 
            420                 425                 430         


Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val Ala Ser 
        435                 440                 445             


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser 
    450                 455                 460                 


Leu Thr Ile Asn Ser Leu Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys 
465                 470                 475                 480 


Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
                485                 490                 495     


Glu Ile Lys 
            


<210>  39
<211>  498
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Bispecific single chain antibody

<400>  39

Gln Ala Val Leu Thr Gln Pro Ala Ser Leu Ser Ala Ser Pro Gly Ala 
1               5                   10                  15      


Ser Ala Ser Leu Thr Cys Thr Leu Arg Arg Gly Ile Asn Val Gly Ala 
            20                  25                  30          


Tyr Ser Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr 
        35                  40                  45              


Leu Leu Arg Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val 
    50                  55                  60                  


Ser Ser Arg Phe Ser Ala Ser Lys Asp Ala Ser Ala Asn Ala Gly Ile 
65                  70                  75                  80  


Leu Leu Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Met Ile Trp His Ser Gly Ala Ser Ala Val Phe Gly Gly Gly Thr Lys 
            100                 105                 110         


Leu Thr Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln 
    130                 135                 140                 


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu 
145                 150                 155                 160 


Ser Thr Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                165                 170                 175     


Glu Trp Val Ala Leu Ile Ser Asn Asp Gly Ser Asn Lys Tyr Tyr Ala 
            180                 185                 190         


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
        195                 200                 205             


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Thr Arg Asp Arg Gly Leu Arg Phe Tyr Phe Asp Tyr Trp 
225                 230                 235                 240 


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp 
                245                 250                 255     


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
            260                 265                 270         


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr 
        275                 280                 285             


Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly 
    290                 295                 300                 


Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Ala Asp Ser Val Lys 
305                 310                 315                 320 


Gly Arg Phe Thr Ile Thr Thr Asp Lys Ser Thr Ser Thr Ala Tyr Met 
                325                 330                 335     


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
            340                 345                 350         


Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr 
        355                 360                 365             


Thr Val Thr Val Ser Ser Gly Glu Gly Thr Ser Thr Gly Ser Gly Gly 
    370                 375                 380                 


Ser Gly Gly Ser Gly Gly Ala Asp Asp Ile Val Leu Thr Gln Ser Pro 
385                 390                 395                 400 


Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg 
                405                 410                 415     


Ala Ser Gln Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly 
            420                 425                 430         


Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val Ala Ser Gly 
        435                 440                 445             


Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu 
    450                 455                 460                 


Thr Ile Asn Ser Leu Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln 
465                 470                 475                 480 


Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu 
                485                 490                 495     


Ile Lys 
        


<210>  40
<211>  499
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Bispecific single chain antibody

<400>  40

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Thr Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Ser Asn Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Gly Leu Arg Phe Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gln Ala Val Leu Thr Gln Pro Ala Ser Leu 
    130                 135                 140                 


Ser Ala Ser Pro Gly Ala Ser Ala Ser Leu Thr Cys Thr Leu Arg Arg 
145                 150                 155                 160 


Gly Ile Asn Val Gly Ala Tyr Ser Ile Tyr Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Ser Pro Pro Gln Tyr Leu Leu Arg Tyr Lys Ser Asp Ser Asp Lys 
            180                 185                 190         


Gln Gln Gly Ser Gly Val Ser Ser Arg Phe Ser Ala Ser Lys Asp Ala 
        195                 200                 205             


Ser Ala Asn Ala Gly Ile Leu Leu Ile Ser Gly Leu Gln Ser Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Met Ile Trp His Ser Gly Ala Ser Ala Val 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Asp Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
            260                 265                 270         


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
        275                 280                 285             


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
    290                 295                 300                 


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Ala Asp Ser Val 
305                 310                 315                 320 


Lys Gly Arg Phe Thr Ile Thr Thr Asp Lys Ser Thr Ser Thr Ala Tyr 
                325                 330                 335     


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
            340                 345                 350         


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
        355                 360                 365             


Thr Thr Val Thr Val Ser Ser Gly Glu Gly Thr Ser Thr Gly Ser Gly 
    370                 375                 380                 


Gly Ser Gly Gly Ser Gly Gly Ala Asp Asp Ile Val Leu Thr Gln Ser 
385                 390                 395                 400 


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
                405                 410                 415     


Arg Ala Ser Gln Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro 
            420                 425                 430         


Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val Ala Ser 
        435                 440                 445             


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser 
    450                 455                 460                 


Leu Thr Ile Asn Ser Leu Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys 
465                 470                 475                 480 


Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
                485                 490                 495     


Glu Ile Lys 
            


<210>  41
<211>  501
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Bispecific single chain antibody

<400>  41

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Phe Ile Arg Asn Lys Ala Asn Gly Gly Thr Thr Glu Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Arg Gly Leu Arg Phe Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Leu Thr Gln Pro Ala 
    130                 135                 140                 


Ser Leu Ser Ala Ser Pro Gly Ala Ser Ala Ser Leu Thr Cys Thr Leu 
145                 150                 155                 160 


Arg Arg Gly Ile Asn Val Gly Ala Tyr Ser Ile Tyr Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Ser Pro Pro Gln Tyr Leu Leu Arg Tyr Lys Ser Asp Ser 
            180                 185                 190         


Asp Lys Gln Gln Gly Ser Gly Val Ser Ser Arg Phe Ser Ala Ser Lys 
        195                 200                 205             


Asp Ala Ser Ala Asn Ala Gly Ile Leu Leu Ile Ser Gly Leu Gln Ser 
    210                 215                 220                 


Glu Asp Glu Ala Asp Tyr Tyr Cys Met Ile Trp His Ser Gly Ala Ser 
225                 230                 235                 240 


Ala Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Asp Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
            260                 265                 270         


Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
        275                 280                 285             


Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 
    290                 295                 300                 


Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Ala Asp 
305                 310                 315                 320 


Ser Val Lys Gly Arg Phe Thr Ile Thr Thr Asp Lys Ser Thr Ser Thr 
                325                 330                 335     


Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr 
            340                 345                 350         


Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly 
        355                 360                 365             


Gln Gly Thr Thr Val Thr Val Ser Ser Gly Glu Gly Thr Ser Thr Gly 
    370                 375                 380                 


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ala Asp Asp Ile Val Leu Thr 
385                 390                 395                 400 


Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
                405                 410                 415     


Ser Cys Arg Ala Ser Gln Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln 
            420                 425                 430         


Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val 
        435                 440                 445             


Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    450                 455                 460                 


Tyr Ser Leu Thr Ile Asn Ser Leu Glu Ala Glu Asp Ala Ala Thr Tyr 
465                 470                 475                 480 


Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Gly Gly Thr 
                485                 490                 495     


Lys Val Glu Ile Lys 
            500     


<210>  42
<211>  499
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Bispecific single chain antibody

<400>  42

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Thr Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Ser Asn Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Asp Arg Gly Leu Arg Phe Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gln Ala Val Leu Thr Gln Pro Ala Ser Leu 
    130                 135                 140                 


Ser Ala Ser Pro Gly Ala Ser Ala Ser Leu Thr Cys Thr Leu Arg Arg 
145                 150                 155                 160 


Gly Ile Asn Val Gly Ala Tyr Ser Ile Tyr Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Ser Pro Pro Gln Tyr Leu Leu Arg Tyr Lys Ser Asp Ser Asp Lys 
            180                 185                 190         


Gln Gln Gly Ser Gly Val Ser Ser Arg Phe Ser Ala Ser Lys Asp Ala 
        195                 200                 205             


Ser Ala Asn Ala Gly Ile Leu Leu Ile Ser Gly Leu Gln Ser Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Met Ile Trp His Ser Gly Ala Ser Ala Val 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Asp Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
            260                 265                 270         


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
        275                 280                 285             


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
    290                 295                 300                 


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Ala Asp Ser Val 
305                 310                 315                 320 


Lys Gly Arg Phe Thr Ile Thr Thr Asp Lys Ser Thr Ser Thr Ala Tyr 
                325                 330                 335     


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
            340                 345                 350         


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
        355                 360                 365             


Thr Thr Val Thr Val Ser Ser Gly Glu Gly Thr Ser Thr Gly Ser Gly 
    370                 375                 380                 


Gly Ser Gly Gly Ser Gly Gly Ala Asp Asp Ile Val Leu Thr Gln Ser 
385                 390                 395                 400 


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
                405                 410                 415     


Arg Ala Ser Gln Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro 
            420                 425                 430         


Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val Ala Ser 
        435                 440                 445             


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser 
    450                 455                 460                 


Leu Thr Ile Asn Ser Leu Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys 
465                 470                 475                 480 


Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
                485                 490                 495     


Glu Ile Lys 
            


<210>  43
<211>  507
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Bispecific single chain antibody

<400>  43

Asp Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Thr Thr Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Gly Glu Gly Thr Ser Thr Gly Ser Gly 
        115                 120                 125             


Gly Ser Gly Gly Ser Gly Gly Ala Asp Asp Ile Val Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val Ala Ser 
            180                 185                 190         


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser 
        195                 200                 205             


Leu Thr Ile Asn Ser Leu Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                245                 250                 255     


Gly Gly Gly Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala 
            260                 265                 270         


Ala Ser Gly Phe Thr Val Ser Ser Tyr Trp Met His Trp Val Arg Gln 
        275                 280                 285             


Ala Pro Gly Lys Gly Leu Glu Trp Val Gly Phe Ile Leu Asn Lys Ala 
    290                 295                 300                 


Asn Gly Gly Thr Thr Glu Tyr Ala Ala Ser Val Lys Gly Arg Phe Thr 
305                 310                 315                 320 


Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
                325                 330                 335     


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Arg Gly 
            340                 345                 350         


Leu Arg Phe Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
        355                 360                 365             


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Glu Leu Val Leu Thr Gln Pro Ala Ser Leu Ser Ala Ser Pro Gly 
385                 390                 395                 400 


Ala Ser Ala Ser Leu Thr Cys Thr Leu Arg Arg Gly Ile Asn Val Gly 
                405                 410                 415     


Ala Tyr Ser Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln 
            420                 425                 430         


Tyr Leu Leu Arg Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly 
        435                 440                 445             


Val Ser Ser Arg Phe Ser Ala Ser Lys Asp Ala Ser Ala Asn Ala Gly 
    450                 455                 460                 


Ile Leu Leu Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr 
465                 470                 475                 480 


Cys Met Ile Trp His Ser Gly Ala Ser Ala Val Phe Gly Gly Gly Thr 
                485                 490                 495     


Lys Leu Thr Val Leu His His His His His His 
            500                 505         


<210>  44
<211>  1473
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Bispecific single-chain antibody

<400>  44
gacattgagc tcacccagtc tccagcaatc ctgtctgcat ctccagggga gaaggtcaca       60

atgacttgca gggccagctc aagtgtaact tacattcact ggtaccagca gaagccagga      120

tcctccccca aatcctggat ttatgccaca tccaacctgg cttctggagt ccctgctcgc      180

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagcagagt ggaggctgaa      240

gatgctgcca cttattactg ccaacattgg agtagtaaac caccgacgtt cggtggaggg      300

accaagctcg agatcaaagg tggtggtggt tctggcggcg gcggctccgg tggtggtggt      360

tctcaggtcc aactgcagga gtcaggagga ggcttggtac agcctggggg ttctctgaga      420

ctctcctgtg caacttctgg gttcaccttc actgattact acatgaactg ggtccgccag      480

cctccaggaa aggcacttga gtggttgggt tttattggaa acaaagctaa tggttacaca      540

acagagtaca gtgcatctgt gaagggtcgg ttcaccatct ccagagataa atcccaaagc      600

atcctctatc ttcaaatgaa caccctgaga gctgaggaca gtgccactta ttactgtacc      660

agagataggg ggctacggtt ctactttgac tactggggcc aagggaccac ggtcaccgtc      720

tcctccggag gtggtggatc cgacgtccaa ctggtgcagt caggggctga agtgaaaaaa      780

cctggggcct cagtgaaggt gtcctgcaag gcttctggct acacctttac taggtacacg      840

atgcactggg taaggcaggc acctggacag ggtctggaat ggattggata cattaatcct      900

agccgtggtt atactaatta cgcagacagc gtcaagggcc gcttcacaat cactacagac      960

aaatccacca gcacagccta catggaactg agcagcctgc gttctgagga cactgcaacc     1020

tattactgtg caagatatta tgatgatcat tactgccttg actactgggg ccaaggcacc     1080

acggtcaccg tctcctcagg cgaaggtact agtactggtt ctggtggaag tggaggttca     1140

ggtggagcag acgacattgt actgacccag tctccagcaa ctctgtctct gtctccaggg     1200

gagcgtgcca ccctgagctg cagagccagt caaagtgtaa gttacatgaa ctggtaccag     1260

cagaagccgg gcaaggcacc caaaagatgg atttatgaca catccaaagt ggcttctgga     1320

gtccctgctc gcttcagtgg cagtgggtct gggaccgact actctctcac aatcaacagc     1380

ttggaggctg aagatgctgc cacttattac tgccaacagt ggagtagtaa cccgctcacg     1440

ttcggtggcg ggaccaaggt ggagatcaaa tag                                  1473


<210>  45
<211>  1476
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Bispecific single chain antibody

<400>  45
caggtccaac tgcaggagtc aggaggaggc ttggtacagc ctgggggttc tctgagactc       60

tcctgtgcaa cttctgggtt caccttcact gattactaca tgaactgggt ccgccagcct      120

ccaggaaagg cacttgagtg gttgggtttt attggaaaca aagctaatgg ttacacaaca      180

gagtacagtg catctgtgaa gggtcggttc accatctcca gagataaatc ccaaagcatc      240

ctctatcttc aaatgaacac cctgagagct gaggacagtg ccacttatta ctgtaccaga      300

gatagggggc tacggttcta ctttgactac tggggccaag ggaccacggt caccgtctcc      360

tccggtggtg gtggttctgg cggcggcggc tccggtggtg gtggttctga cattgagctc      420

acccagtctc cagcaatcct gtctgcatct ccaggggaga aggtcacaat gacttgcagg      480

gccagctcaa gtgtaactta cattcactgg taccagcaga agccaggatc ctcccccaaa      540

tcctggattt atgccacatc caacctggct tctggagtcc ctgctcgctt cagtggcagt      600

gggtctggga cctcttactc tctcacaatc agcagagtgg aggctgaaga tgctgccact      660

tattactgcc aacattggag tagtaaacca ccgacgttcg gtggagggac caagctcgag      720

atcaaatccg gaggtggtgg atccgacgtc caactggtgc agtcaggggc tgaagtgaaa      780

aaacctgggg cctcagtgaa ggtgtcctgc aaggcttctg gctacacctt tactaggtac      840

acgatgcact gggtaaggca ggcacctgga cagggtctgg aatggattgg atacattaat      900

cctagccgtg gttatactaa ttacgcagac agcgtcaagg gccgcttcac aatcactaca      960

gacaaatcca ccagcacagc ctacatggaa ctgagcagcc tgcgttctga ggacactgca     1020

acctattact gtgcaagata ttatgatgat cattactgcc ttgactactg gggccaaggc     1080

accacggtca ccgtctcctc aggcgaaggt actagtactg gttctggtgg aagtggaggt     1140

tcaggtggag cagacgacat tgtactgacc cagtctccag caactctgtc tctgtctcca     1200

ggggagcgtg ccaccctgag ctgcagagcc agtcaaagtg taagttacat gaactggtac     1260

cagcagaagc cgggcaaggc acccaaaaga tggatttatg acacatccaa agtggcttct     1320

ggagtccctg ctcgcttcag tggcagtggg tctgggaccg actactctct cacaatcaac     1380

agcttggagg ctgaagatgc tgccacttat tactgccaac agtggagtag taacccgctc     1440

acgttcggtg gcgggaccaa ggtggagatc aaatag                               1476


<210>  46
<211>  1506
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Bispecific single chain antibody

<400>  46
gaggtgcagc tggtcgagtc aggaggaggc ttggtacagc ctgggggttc tctgagactc       60

tcctgtgcaa cttctgggtt caccttcact gattactaca tgaactgggt ccgccagcct      120

ccaggaaagg cacttgagtg gttgggtttt attggaaaca aagctaatgg ttacacaaca      180

gagtacagtg catctgtgaa gggtcggttc accatctcca gagataaatc ccaaagcatc      240

ctctatcttc aaatgaacac cctgagagct gaggacagtg ccacttatta ctgtaccaga      300

gatagggggc tacggttcta ctttgactac tggggccaag ggaccacggt caccgtctcc      360

tcaggtggtg gtggttctgg cggcggcggc tccggtggtg gtggttctca ggccgtgctg      420

actcagccgg cttccctctc tgcatctcct ggagcatcag ccagtctcac ctgcaccttg      480

cgcaggggca tcaatgttgg tgcctacagt atatactggt accagcagaa gccagggagt      540

cctccccagt atctcctgag gtacaaatca gactcagata agcagcaggg ctctggagtc      600

tccagccgct tctctgcatc caaagatgct tcggccaatg cagggatttt actcatctct      660

gggctccagt ctgaggatga ggctgactat tactgtatga tttggcacag cggcgcttct      720

gcggtgttcg gcggagggac caagttgacc gtcctatccg gaggtggtgg atccgacgtc      780

caactggtgc agtcaggggc tgaagtgaaa aaacctgggg cctcagtgaa ggtgtcctgc      840

aaggcttctg gctacacctt tactaggtac acgatgcact gggtaaggca ggcacctgga      900

cagggtctgg aatggattgg atacattaat cctagccgtg gttatactaa ttacgcagac      960

agcgtcaagg gccgcttcac aatcactaca gacaaatcca ccagcacagc ctacatggaa     1020

ctgagcagcc tgcgttctga ggacactgca acctattact gtgcaagata ttatgatgat     1080

cattactgcc ttgactactg gggccaaggc accacggtca ccgtctcctc aggcgaaggt     1140

actagtactg gttctggtgg aagtggaggt tcaggtggag cagacgacat tgtactgacc     1200

cagtctccag caactctgtc tctgtctcca ggggagcgtg ccaccctgag ctgcagagcc     1260

agtcaaagtg taagttacat gaactggtac cagcagaagc cgggcaaggc acccaaaaga     1320

tggatttatg acacatccaa agtggcttct ggagtccctg ctcgcttcag tggcagtggg     1380

tctgggaccg actactctct cacaatcaac agcttggagg ctgaagatgc tgccacttat     1440

tactgccaac agtggagtag taacccgctc acgttcggtg gcgggaccaa ggtggagatc     1500

aaatag                                                                1506


<210>  47
<211>  1503
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Bispecific single chain antibody

<400>  47
caggccgtgc tgactcagcc ggcttccctc tctgcatctc ctggagcatc agccagtctc       60

acctgcacct tgcgcagggg catcaatgtt ggtgcctaca gtatatactg gtaccagcag      120

aagccaggga gtcctcccca gtatctcctg aggtacaaat cagactcaga taagcagcag      180

ggctctggag tctccagccg cttctctgca tccaaagatg cttcggccaa tgcagggatt      240

ttactcatct ctgggctcca gtctgaggat gaggctgact attactgtat gatttggcac      300

agcggcgctt ctgcggtgtt cggcggaggg accaagttga ccgtcctagg tggtggtggt      360

tctggcggcg gcggctccgg tggtggtggt tctgaggtgc agctggtcga gtcaggagga      420

ggcttggtac agcctggggg ttctctgaga ctctcctgtg caacttctgg gttcaccttc      480

actgattact acatgaactg ggtccgccag cctccaggaa aggcacttga gtggttgggt      540

tttattggaa acaaagctaa tggttacaca acagagtaca gtgcatctgt gaagggtcgg      600

ttcaccatct ccagagataa atcccaaagc atcctctatc ttcaaatgaa caccctgaga      660

gctgaggaca gtgccactta ttactgtacc agagataggg ggctacggtt ctactttgac      720

tactggggcc aagggaccac ggtcaccgtc tcctccggag gtggtggatc cgacgtccaa      780

ctggtgcagt caggggctga agtgaaaaaa cctggggcct cagtgaaggt gtcctgcaag      840

gcttctggct acacctttac taggtacacg atgcactggg taaggcaggc acctggacag      900

ggtctggaat ggattggata cattaatcct agccgtggtt atactaatta cgcagacagc      960

gtcaagggcc gcttcacaat cactacagac aaatccacca gcacagccta catggaactg     1020

agcagcctgc gttctgagga cactgcaacc tattactgtg caagatatta tgatgatcat     1080

tactgccttg actactgggg ccaaggcacc acggtcaccg tctcctcagg cgaaggtact     1140

agtactggtt ctggtggaag tggaggttca ggtggagcag acgacattgt actgacccag     1200

tctccagcaa ctctgtctct gtctccaggg gagcgtgcca ccctgagctg cagagccagt     1260

caaagtgtaa gttacatgaa ctggtaccag cagaagccgg gcaaggcacc caaaagatgg     1320

atttatgaca catccaaagt ggcttctgga gtccctgctc gcttcagtgg cagtgggtct     1380

gggaccgact actctctcac aatcaacagc ttggaggctg aagatgctgc cacttattac     1440

tgccaacagt ggagtagtaa cccgctcacg ttcggtggcg ggaccaaggt ggagatcaaa     1500

tag                                                                   1503


<210>  48
<211>  1500
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Bispecific single chain antibody

<400>  48
gaggtgcagc tggtcgagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccctcagt acctatgcca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcactt atatcaaatg atggaagcaa taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggccgtgt attactgtgc gagagatagg      300

gggctacggt tctactttga ctactggggc caagggacca cggtcaccgt ctcctcaggt      360

ggtggtggtt ctggcggcgg cggctccggt ggtggtggtt ctgagctcgt gctgactcag      420

ccggcttccc tctctgcatc tcctggagca tcagccagtc tcacctgcac cttgcgcagg      480

ggcatcaatg ttggtgccta cagtatatac tggtaccagc agaagccagg gagtcctccc      540

cagtatctcc tgaggtacaa atcagactca gataagcagc agggctctgg agtctccagc      600

cgcttctctg catccaaaga tgcttcggcc aatgcaggga ttttactcat ctctgggctc      660

cagtctgagg atgaggctga ctattactgt atgatttggc acagcggcgc ttctgcggtg      720

ttcggcggag ggaccaagtt gaccgtccta tccggaggtg gtggatccga cgtccaactg      780

gtgcagtcag gggctgaagt gaaaaaacct ggggcctcag tgaaggtgtc ctgcaaggct      840

tctggctaca cctttactag gtacacgatg cactgggtaa ggcaggcacc tggacagggt      900

ctggaatgga ttggatacat taatcctagc cgtggttata ctaattacgc agacagcgtc      960

aagggccgct tcacaatcac tacagacaaa tccaccagca cagcctacat ggaactgagc     1020

agcctgcgtt ctgaggacac tgcaacctat tactgtgcaa gatattatga tgatcattac     1080

tgccttgact actggggcca aggcaccacg gtcaccgtct cctcaggcga aggtactagt     1140

actggttctg gtggaagtgg aggttcaggt ggagcagacg acattgtact gacccagtct     1200

ccagcaactc tgtctctgtc tccaggggag cgtgccaccc tgagctgcag agccagtcaa     1260

agtgtaagtt acatgaactg gtaccagcag aagccgggca aggcacccaa aagatggatt     1320

tatgacacat ccaaagtggc ttctggagtc cctgctcgct tcagtggcag tgggtctggg     1380

accgactact ctctcacaat caacagcttg gaggctgaag atgctgccac ttattactgc     1440

caacagtgga gtagtaaccc gctcacgttc ggtggcggga ccaaggtgga gatcaaatag     1500


<210>  49
<211>  1497
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Bispecific single chain antibody

<400>  49
caggccgtgc tgactcagcc ggcttccctc tctgcatctc ctggagcatc agccagtctc       60

acctgcacct tgcgcagggg catcaatgtt ggtgcctaca gtatatactg gtaccagcag      120

aagccaggga gtcctcccca gtatctcctg aggtacaaat cagactcaga taagcagcag      180

ggctctggag tctccagccg cttctctgca tccaaagatg cttcggccaa tgcagggatt      240

ttactcatct ctgggctcca gtctgaggat gaggctgact attactgtat gatttggcac      300

agcggcgctt ctgcggtgtt cggcggaggg accaagttga ccgtcctagg tggtggtggt      360

tctggcggcg gcggctccgg tggtggtggt tctgaggtgc agctggtcga gtctggggga      420

ggcgtggtcc agcctgggag gtccctgaga ctctcctgtg cagcctctgg attcaccctc      480

agtacctatg ccatgcactg ggtccgccag gctccaggca aggggctgga gtgggtggca      540

cttatatcaa atgatggaag caataaatac tatgcagact ccgtgaaggg ccgattcacc      600

atctccagag acaattccaa gaacacgctg tatctgcaaa tgaacagcct gagagctgag      660

gacacggccg tgtattactg tgcgagagat agggggctac ggttctactt tgactactgg      720

ggccaaggga ccacggtcac cgtctcctcc ggaggtggtg gatccgacgt ccaactggtg      780

cagtcagggg ctgaagtgaa aaaacctggg gcctcagtga aggtgtcctg caaggcttct      840

ggctacacct ttactaggta cacgatgcac tgggtaaggc aggcacctgg acagggtctg      900

gaatggattg gatacattaa tcctagccgt ggttatacta attacgcaga cagcgtcaag      960

ggccgcttca caatcactac agacaaatcc accagcacag cctacatgga actgagcagc     1020

ctgcgttctg aggacactgc aacctattac tgtgcaagat attatgatga tcattactgc     1080

cttgactact ggggccaagg caccacggtc accgtctcct caggcgaagg tactagtact     1140

ggttctggtg gaagtggagg ttcaggtgga gcagacgaca ttgtactgac ccagtctcca     1200

gcaactctgt ctctgtctcc aggggagcgt gccaccctga gctgcagagc cagtcaaagt     1260

gtaagttaca tgaactggta ccagcagaag ccgggcaagg cacccaaaag atggatttat     1320

gacacatcca aagtggcttc tggagtccct gctcgcttca gtggcagtgg gtctgggacc     1380

gactactctc tcacaatcaa cagcttggag gctgaagatg ctgccactta ttactgccaa     1440

cagtggagta gtaacccgct cacgttcggt ggcgggacca aggtggagat caaatag        1497


<210>  50
<211>  1506
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Bispecific single chain antibody

<400>  50
gaggtgcagc tggtcgagtc tgggggaggc ttggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cgtctggatt caccgtcagt agctactgga tgcactgggt ccgccaagct      120

ccagggaagg ggctggaatg ggtaggtttc attagaaaca aagctaatgg tgggacaaca      180

gaatacgccg cgtctgtgaa aggcagattc accatctcaa gagatgattc caagaacacg      240

ctgtatcttc aaatgaacag cctgagagcc gaggacacgg ccgtgtatta ctgtgcaaga      300

gatagggggc tacggttcta ctttgactac tggggccaag ggaccacggt caccgtctcc      360

tcaggtggtg gtggttctgg cggcggcggc tccggtggtg gtggttctga gctcgtgctg      420

actcagccgg cttccctctc tgcatctcct ggagcatcag ccagtctcac ctgcaccttg      480

cgcaggggca tcaatgttgg tgcctacagt atatactggt accagcagaa gccagggagt      540

cctccccagt atctcctgag gtacaaatca gactcagata agcagcaggg ctctggagtc      600

tccagccgct tctctgcatc caaagatgct tcggccaatg cagggatttt actcatctct      660

gggctccagt ctgaggatga ggctgactat tactgtatga tttggcacag cggcgcttct      720

gcggtgttcg gcggagggac caagttgacc gtcctatccg gaggtggtgg atccgacgtc      780

caactggtgc agtcaggggc tgaagtgaaa aaacctgggg cctcagtgaa ggtgtcctgc      840

aaggcttctg gctacacctt tactaggtac acgatgcact gggtaaggca ggcacctgga      900

cagggtctgg aatggattgg atacattaat cctagccgtg gttatactaa ttacgcagac      960

agcgtcaagg gccgcttcac aatcactaca gacaaatcca ccagcacagc ctacatggaa     1020

ctgagcagcc tgcgttctga ggacactgca acctattact gtgcaagata ttatgatgat     1080

cattactgcc ttgactactg gggccaaggc accacggtca ccgtctcctc aggcgaaggt     1140

actagtactg gttctggtgg aagtggaggt tcaggtggag cagacgacat tgtactgacc     1200

cagtctccag caactctgtc tctgtctcca ggggagcgtg ccaccctgag ctgcagagcc     1260

agtcaaagtg taagttacat gaactggtac cagcagaagc cgggcaaggc acccaaaaga     1320

tggatttatg acacatccaa agtggcttct ggagtccctg ctcgcttcag tggcagtggg     1380

tctgggaccg actactctct cacaatcaac agcttggagg ctgaagatgc tgccacttat     1440

tactgccaac agtggagtag taacccgctc acgttcggtg gcgggaccaa ggtggagatc     1500

aaatag                                                                1506


<210>  51
<211>  1503
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Bispecific single chain antibody

<400>  51
caggccgtgc tgactcagcc ggcttccctc tctgcatctc ctggagcatc agccagtctc       60

acctgcacct tgcgcagggg catcaatgtt ggtgcctaca gtatatactg gtaccagcag      120

aagccaggga gtcctcccca gtatctcctg aggtacaaat cagactcaga taagcagcag      180

ggctctggag tctccagccg cttctctgca tccaaagatg cttcggccaa tgcagggatt      240

ttactcatct ctgggctcca gtctgaggat gaggctgact attactgtat gatttggcac      300

agcggcgctt ctgcggtgtt cggcggaggg accaagttga ccgtcctagg tggtggtggt      360

tctggcggcg gcggctccgg tggtggtggt tctgaggtgc agctggtcga gtctggggga      420

ggcttggtcc agcctgggag gtccctgaga ctctcctgtg cagcgtctgg attcaccgtc      480

agtagctact ggatgcactg ggtccgccaa gctccaggga aggggctgga atgggtaggt      540

ttcattagaa acaaagctaa tggtgggaca acagaatacg ccgcgtctgt gaaaggcaga      600

ttcaccatct caagagatga ttccaagaac acgctgtatc ttcaaatgaa cagcctgaga      660

gccgaggaca cggccgtgta ttactgtgca agagataggg ggctacggtt ctactttgac      720

tactggggcc aagggaccac ggtcaccgtc tcctccggag gtggtggatc cgacgtccaa      780

ctggtgcagt caggggctga agtgaaaaaa cctggggcct cagtgaaggt gtcctgcaag      840

gcttctggct acacctttac taggtacacg atgcactggg taaggcaggc acctggacag      900

ggtctggaat ggattggata cattaatcct agccgtggtt atactaatta cgcagacagc      960

gtcaagggcc gcttcacaat cactacagac aaatccacca gcacagccta catggaactg     1020

agcagcctgc gttctgagga cactgcaacc tattactgtg caagatatta tgatgatcat     1080

tactgccttg actactgggg ccaaggcacc acggtcaccg tctcctcagg cgaaggtact     1140

agtactggtt ctggtggaag tggaggttca ggtggagcag acgacattgt actgacccag     1200

tctccagcaa ctctgtctct gtctccaggg gagcgtgcca ccctgagctg cagagccagt     1260

caaagtgtaa gttacatgaa ctggtaccag cagaagccgg gcaaggcacc caaaagatgg     1320

atttatgaca catccaaagt ggcttctgga gtccctgctc gcttcagtgg cagtgggtct     1380

gggaccgact actctctcac aatcaacagc ttggaggctg aagatgctgc cacttattac     1440

tgccaacagt ggagtagtaa cccgctcacg ttcggtggcg ggaccaaggt ggagatcaaa     1500

tag                                                                   1503


<210>  52
<211>  1500
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Bispecific single chain antibody

<400>  52
gaggtgcagc tggtcgagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccctcagt acctatgcca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcactt atatcaaatg atggaagcaa taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtac tagagatagg      300

gggctacggt tctactttga ctactggggc caagggacca cggtcaccgt ctcctcaggt      360

ggtggtggtt ctggcggcgg cggctccggt ggtggtggtt ctgagctcgt gctgactcag      420

ccggcttccc tctctgcatc tcctggagca tcagccagtc tcacctgcac cttgcgcagg      480

ggcatcaatg ttggtgccta cagtatatac tggtaccagc agaagccagg gagtcctccc      540

cagtatctcc tgaggtacaa atcagactca gataagcagc agggctctgg agtctccagc      600

cgcttctctg catccaaaga tgcttcggcc aatgcaggga ttttactcat ctctgggctc      660

cagtctgagg atgaggctga ctattactgt atgatttggc acagcggcgc ttctgcggtg      720

ttcggcggag ggaccaagtt gaccgtccta tccggaggtg gtggatccga cgtccaactg      780

gtgcagtcag gggctgaagt gaaaaaacct ggggcctcag tgaaggtgtc ctgcaaggct      840

tctggctaca cctttactag gtacacgatg cactgggtaa ggcaggcacc tggacagggt      900

ctggaatgga ttggatacat taatcctagc cgtggttata ctaattacgc agacagcgtc      960

aagggccgct tcacaatcac tacagacaaa tccaccagca cagcctacat ggaactgagc     1020

agcctgcgtt ctgaggacac tgcaacctat tactgtgcaa gatattatga tgatcattac     1080

tgccttgact actggggcca aggcaccacg gtcaccgtct cctcaggcga aggtactagt     1140

actggttctg gtggaagtgg aggttcaggt ggagcagacg acattgtact gacccagtct     1200

ccagcaactc tgtctctgtc tccaggggag cgtgccaccc tgagctgcag agccagtcaa     1260

agtgtaagtt acatgaactg gtaccagcag aagccgggca aggcacccaa aagatggatt     1320

tatgacacat ccaaagtggc ttctggagtc cctgctcgct tcagtggcag tgggtctggg     1380

accgactact ctctcacaat caacagcttg gaggctgaag atgctgccac ttattactgc     1440

caacagtgga gtagtaaccc gctcacgttc ggtggcggga ccaaggtgga gatcaaatag     1500


<210>  53
<211>  1497
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Bispecific single chain antibody

<400>  53
caggccgtgc tgactcagcc ggcttccctc tctgcatctc ctggagcatc agccagtctc       60

acctgcacct tgcgcagggg catcaatgtt ggtgcctaca gtatatactg gtaccagcag      120

aagccaggga gtcctcccca gtatctcctg aggtacaaat cagactcaga taagcagcag      180

ggctctggag tctccagccg cttctctgca tccaaagatg cttcggccaa tgcagggatt      240

ttactcatct ctgggctcca gtctgaggat gaggctgact attactgtat gatttggcac      300

agcggcgctt ctgcggtgtt cggcggaggg accaagttga ccgtcctagg tggtggtggt      360

tctggcggcg gcggctccgg tggtggtggt tctgaggtgc agctggtcga gtctggggga      420

ggcgtggtcc agcctgggag gtccctgaga ctctcctgtg cagcctctgg attcaccctc      480

agtacctatg ccatgcactg ggtccgccag gctccaggca aggggctgga gtgggtggca      540

cttatatcaa atgatggaag caataaatac tatgcagact ccgtgaaggg ccgattcacc      600

atctccagag acaattccaa gaacacgctg tatctgcaaa tgaacagcct gagagctgag      660

gacacggctg tgtattactg tactagagat agggggctac ggttctactt tgactactgg      720

ggccaaggga ccacggtcac cgtctcctcc ggaggtggtg gatccgacgt ccaactggtg      780

cagtcagggg ctgaagtgaa aaaacctggg gcctcagtga aggtgtcctg caaggcttct      840

ggctacacct ttactaggta cacgatgcac tgggtaaggc aggcacctgg acagggtctg      900

gaatggattg gatacattaa tcctagccgt ggttatacta attacgcaga cagcgtcaag      960

ggccgcttca caatcactac agacaaatcc accagcacag cctacatgga actgagcagc     1020

ctgcgttctg aggacactgc aacctattac tgtgcaagat attatgatga tcattactgc     1080

cttgactact ggggccaagg caccacggtc accgtctcct caggcgaagg tactagtact     1140

ggttctggtg gaagtggagg ttcaggtgga gcagacgaca ttgtactgac ccagtctcca     1200

gcaactctgt ctctgtctcc aggggagcgt gccaccctga gctgcagagc cagtcaaagt     1260

gtaagttaca tgaactggta ccagcagaag ccgggcaagg cacccaaaag atggatttat     1320

gacacatcca aagtggcttc tggagtccct gctcgcttca gtggcagtgg gtctgggacc     1380

gactactctc tcacaatcaa cagcttggag gctgaagatg ctgccactta ttactgccaa     1440

cagtggagta gtaacccgct cacgttcggt ggcgggacca aggtggagat caaatag        1497


<210>  54
<211>  1500
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Bispecific single chain antibody

<400>  54
gaggtgcagc tggtcgagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccctcagt acctatgcca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcactt atatcaaatg atggaagcaa taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggccgtgt attactgtgc gagagatagg      300

gggctacggt tctactttga ctactggggc caagggacca cggtcaccgt ctcctcaggt      360

ggtggtggtt ctggcggcgg cggctccggt ggtggtggtt ctcaggccgt gctgactcag      420

ccggcttccc tctctgcatc tcctggagca tcagccagtc tcacctgcac cttgcgcagg      480

ggcatcaatg ttggtgccta cagtatatac tggtaccagc agaagccagg gagtcctccc      540

cagtatctcc tgaggtacaa atcagactca gataagcagc agggctctgg agtctccagc      600

cgcttctctg catccaaaga tgcttcggcc aatgcaggga ttttactcat ctctgggctc      660

cagtctgagg atgaggctga ctattactgt atgatttggc acagcggcgc ttctgcggtg      720

ttcggcggag ggaccaagtt gaccgtccta tccggaggtg gtggatccga cgtccaactg      780

gtgcagtcag gggctgaagt gaaaaaacct ggggcctcag tgaaggtgtc ctgcaaggct      840

tctggctaca cctttactag gtacacgatg cactgggtaa ggcaggcacc tggacagggt      900

ctggaatgga ttggatacat taatcctagc cgtggttata ctaattacgc agacagcgtc      960

aagggccgct tcacaatcac tacagacaaa tccaccagca cagcctacat ggaactgagc     1020

agcctgcgtt ctgaggacac tgcaacctat tactgtgcaa gatattatga tgatcattac     1080

tgccttgact actggggcca aggcaccacg gtcaccgtct cctcaggcga aggtactagt     1140

actggttctg gtggaagtgg aggttcaggt ggagcagacg acattgtact gacccagtct     1200

ccagcaactc tgtctctgtc tccaggggag cgtgccaccc tgagctgcag agccagtcaa     1260

agtgtaagtt acatgaactg gtaccagcag aagccgggca aggcacccaa aagatggatt     1320

tatgacacat ccaaagtggc ttctggagtc cctgctcgct tcagtggcag tgggtctggg     1380

accgactact ctctcacaat caacagcttg gaggctgaag atgctgccac ttattactgc     1440

caacagtgga gtagtaaccc gctcacgttc ggtggcggga ccaaggtgga gatcaaatag     1500


<210>  55
<211>  1506
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Bispecific single chain antibody

<400>  55
gaggtgcagc tggtcgagtc tgggggaggc ttggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cgtctggatt caccgtcagt agctactgga tgcactgggt ccgccaagct      120

ccagggaagg ggctggaatg ggtaggtttc attagaaaca aagctaatgg tgggacaaca      180

gaatacgccg cgtctgtgaa aggcagattc accatctcaa gagatgattc caagaacacg      240

ctgtatcttc aaatgaacag cctgagagcc gaggacacgg ccgtgtatta ctgtgcaaga      300

gatagggggc tacggttcta ctttgactac tggggccaag ggaccacggt caccgtctcc      360

tcaggtggtg gtggttctgg cggcggcggc tccggtggtg gtggttctca ggccgtgctg      420

actcagccgg cttccctctc tgcatctcct ggagcatcag ccagtctcac ctgcaccttg      480

cgcaggggca tcaatgttgg tgcctacagt atatactggt accagcagaa gccagggagt      540

cctccccagt atctcctgag gtacaaatca gactcagata agcagcaggg ctctggagtc      600

tccagccgct tctctgcatc caaagatgct tcggccaatg cagggatttt actcatctct      660

gggctccagt ctgaggatga ggctgactat tactgtatga tttggcacag cggcgcttct      720

gcggtgttcg gcggagggac caagttgacc gtcctatccg gaggtggtgg atccgacgtc      780

caactggtgc agtcaggggc tgaagtgaaa aaacctgggg cctcagtgaa ggtgtcctgc      840

aaggcttctg gctacacctt tactaggtac acgatgcact gggtaaggca ggcacctgga      900

cagggtctgg aatggattgg atacattaat cctagccgtg gttatactaa ttacgcagac      960

agcgtcaagg gccgcttcac aatcactaca gacaaatcca ccagcacagc ctacatggaa     1020

ctgagcagcc tgcgttctga ggacactgca acctattact gtgcaagata ttatgatgat     1080

cattactgcc ttgactactg gggccaaggc accacggtca ccgtctcctc aggcgaaggt     1140

actagtactg gttctggtgg aagtggaggt tcaggtggag cagacgacat tgtactgacc     1200

cagtctccag caactctgtc tctgtctcca ggggagcgtg ccaccctgag ctgcagagcc     1260

agtcaaagtg taagttacat gaactggtac cagcagaagc cgggcaaggc acccaaaaga     1320

tggatttatg acacatccaa agtggcttct ggagtccctg ctcgcttcag tggcagtggg     1380

tctgggaccg actactctct cacaatcaac agcttggagg ctgaagatgc tgccacttat     1440

tactgccaac agtggagtag taacccgctc acgttcggtg gcgggaccaa ggtggagatc     1500

aaatag                                                                1506


<210>  56
<211>  1500
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Bispecific single chain antibody

<400>  56
gaggtgcagc tggtcgagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccctcagt acctatgcca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcactt atatcaaatg atggaagcaa taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtac tagagatagg      300

gggctacggt tctactttga ctactggggc caagggacca cggtcaccgt ctcctcaggt      360

ggtggtggtt ctggcggcgg cggctccggt ggtggtggtt ctcaggccgt gctgactcag      420

ccggcttccc tctctgcatc tcctggagca tcagccagtc tcacctgcac cttgcgcagg      480

ggcatcaatg ttggtgccta cagtatatac tggtaccagc agaagccagg gagtcctccc      540

cagtatctcc tgaggtacaa atcagactca gataagcagc agggctctgg agtctccagc      600

cgcttctctg catccaaaga tgcttcggcc aatgcaggga ttttactcat ctctgggctc      660

cagtctgagg atgaggctga ctattactgt atgatttggc acagcggcgc ttctgcggtg      720

ttcggcggag ggaccaagtt gaccgtccta tccggaggtg gtggatccga cgtccaactg      780

gtgcagtcag gggctgaagt gaaaaaacct ggggcctcag tgaaggtgtc ctgcaaggct      840

tctggctaca cctttactag gtacacgatg cactgggtaa ggcaggcacc tggacagggt      900

ctggaatgga ttggatacat taatcctagc cgtggttata ctaattacgc agacagcgtc      960

aagggccgct tcacaatcac tacagacaaa tccaccagca cagcctacat ggaactgagc     1020

agcctgcgtt ctgaggacac tgcaacctat tactgtgcaa gatattatga tgatcattac     1080

tgccttgact actggggcca aggcaccacg gtcaccgtct cctcaggcga aggtactagt     1140

actggttctg gtggaagtgg aggttcaggt ggagcagacg acattgtact gacccagtct     1200

ccagcaactc tgtctctgtc tccaggggag cgtgccaccc tgagctgcag agccagtcaa     1260

agtgtaagtt acatgaactg gtaccagcag aagccgggca aggcacccaa aagatggatt     1320

tatgacacat ccaaagtggc ttctggagtc cctgctcgct tcagtggcag tgggtctggg     1380

accgactact ctctcacaat caacagcttg gaggctgaag atgctgccac ttattactgc     1440

caacagtgga gtagtaaccc gctcacgttc ggtggcggga ccaaggtgga gatcaaatag     1500


<210>  57
<211>  1524
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Bispecific single chain antibody

<400>  57
gacgtccaac tggtgcagtc aggggctgaa gtgaaaaaac ctggggcctc agtgaaggtg       60

tcctgcaagg cttctggcta cacctttact aggtacacga tgcactgggt aaggcaggca      120

cctggacagg gtctggaatg gattggatac attaatccta gccgtggtta tactaattac      180

gcagacagcg tcaagggccg cttcacaatc actacagaca aatccaccag cacagcctac      240

atggaactga gcagcctgcg ttctgaggac actgcaacct attactgtgc aagatattat      300

gatgatcatt actgccttga ctactggggc caaggcacca cggtcaccgt ctcctcaggc      360

gaaggtacta gtactggttc tggtggaagt ggaggttcag gtggagcaga cgacattgta      420

ctgacccagt ctccagcaac tctgtctctg tctccagggg agcgtgccac cctgagctgc      480

agagccagtc aaagtgtaag ttacatgaac tggtaccagc agaagccggg caaggcaccc      540

aaaagatgga tttatgacac atccaaagtg gcttctggag tccctgctcg cttcagtggc      600

agtgggtctg ggaccgacta ctctctcaca atcaacagct tggaggctga agatgctgcc      660

acttattact gccaacagtg gagtagtaac ccgctcacgt tcggtggcgg gaccaaggtg      720

gagatcaaat ccggaggtgg tggatccgag gtgcagctgg tcgagtctgg gggaggcttg      780

gtccagcctg ggaggtccct gagactctcc tgtgcagcgt ctggattcac cgtcagtagc      840

tactggatgt actgggtccg ccaagctcca gggaaggggc tggaatgggt aggtttcatt      900

ctcaacaaag ctaatggtgg aacaacagaa tacgccgcgt ctgtgaaagg cagattcacc      960

atctcaagag atgattccaa gaacacgctg tatcttcaaa tgaacagcct gagagccgag     1020

gacacggccg tgtattactg tgcaagagat agggggctac ggttctactt tgactactgg     1080

ggccaaggga ccacggtcac cgtctcctca ggtggtggtg gttctggcgg cggcggctcc     1140

ggtggtggtg gttctgagct cgtgctgact cagccggctt ccctctctgc atctcctgga     1200

gcatcagcca gtctcacctg caccttgcgc aggggcatca atgttggtgc ctacagtata     1260

tactggtacc agcagaagcc agggagtcct ccccagtatc tcctgaggta caaatcagac     1320

tcagataagc agcagggctc tggagtctcc agccgcttct ctgcatccaa agatgcttcg     1380

gccaatgcag ggattttact catctctggg ctccagtctg aggatgaggc tgactattac     1440

tgtatgattt ggcacagcgg cgcttctgcg gtgttcggcg gagggaccaa gttgaccgtc     1500

ctacatcatc accatcatca ttag                                            1524


<210>  58
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr 
            20                  25                  30          


Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
        35                  40                  45              


Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys 
    50                  55                  60                  


Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp 
65                  70                  75                  80  


His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr 
                85                  90                  95      


Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu 
            100                 105                 110         


Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Val Met 
        115                 120                 125             


Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu 
    130                 135                 140                 


Leu Leu Leu Val Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys 
145                 150                 155                 160 


Pro Val Thr Arg Gly Ala Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn 
                165                 170                 175     


Lys Glu Arg Pro Pro Pro Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg 
            180                 185                 190         


Lys Gly Gln Arg Asp Leu Tyr Ser Gly Leu Asn Gln Arg Arg Ile 
        195                 200                 205         


<210>  59
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ser Gln Val Ser Pro Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg 
            20                  25                  30          


Val Phe Val Asn Cys Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val 
        35                  40                  45              


Gly Thr Leu Leu Ser Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile 
    50                  55                  60                  


Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys 
65                  70                  75                  80  


Asp Lys Glu Ser Thr Val Gln Val His Tyr Arg Met Cys Gln Ser Cys 
                85                  90                  95      


Val Glu Leu Asp Pro Ala Thr Val Ala Gly Ile Ile Val Thr Asp Val 
            100                 105                 110         


Ile Ala Thr Leu Leu Leu Ala Leu Gly Val Phe Cys Phe Ala Gly His 
        115                 120                 125             


Glu Thr Gly Arg Leu Ser Gly Ala Ala Asp Thr Gln Ala Leu Leu Arg 
    130                 135                 140                 


Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp Asp Ala Gln Tyr 
145                 150                 155                 160 


Ser His Leu Gly Gly Asn Trp Ala Arg Asn Lys 
                165                 170     


<210>  60
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Glu Gln Gly Lys Gly Leu Ala Val Leu Ile Leu Ala Ile Ile Leu 
1               5                   10                  15      


Leu Gln Gly Thr Leu Ala Gln Ser Ile Lys Gly Asn His Leu Val Lys 
            20                  25                  30          


Val Tyr Asp Tyr Gln Glu Asp Gly Ser Val Leu Leu Thr Cys Asp Ala 
        35                  40                  45              


Glu Ala Lys Asn Ile Thr Trp Phe Lys Asp Gly Lys Met Ile Gly Phe 
    50                  55                  60                  


Leu Thr Glu Asp Lys Lys Lys Trp Asn Leu Gly Ser Asn Ala Lys Asp 
65                  70                  75                  80  


Pro Arg Gly Met Tyr Gln Cys Lys Gly Ser Gln Asn Lys Ser Lys Pro 
                85                  90                  95      


Leu Gln Val Tyr Tyr Arg Met Cys Gln Asn Cys Ile Glu Leu Asn Ala 
            100                 105                 110         


Ala Thr Ile Ser Gly Phe Leu Phe Ala Glu Ile Val Ser Ile Phe Val 
        115                 120                 125             


Leu Ala Val Gly Val Tyr Phe Ile Ala Gly Gln Asp Gly Val Arg Gln 
    130                 135                 140                 


Ser Arg Ala Ser Asp Lys Gln Thr Leu Leu Pro Asn Asp Gln Leu Tyr 
145                 150                 155                 160 


Gln Pro Leu Lys Asp Arg Glu Asp Asp Gln Tyr Ser His Leu Gln Gly 
                165                 170                 175     


Asn Gln Leu Arg Arg Asn 
            180         


<210>  61
<211>  164
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            100                 105                 110         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        115                 120                 125             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    130                 135                 140                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
145                 150                 155                 160 


Leu Pro Pro Arg 
                


<210>  62
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  62

Asp Ile Val Met Thr Gln Ser His Lys Leu Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Asp Ser Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Val Glu Leu Lys 
            100                 105         


<210>  63
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  63

Glu Val Lys Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu Glu Tyr Val 
        35                  40                  45              


Gly Tyr Ile Ser Tyr Thr Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Tyr Tyr Leu 
65                  70                  75                  80  


Gln Leu Asn Ser Val Thr Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Gly Gly Trp Leu Ser Pro Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  64
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  64

Asp Ile Val Thr Thr Gln Ser His Lys Leu Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Asp Ser Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Val Glu Leu Lys 
            100                 105         


<210>  65
<211>  120
<212>  PRT
<213>  Mus musculus

<400>  65

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Thr Tyr 
            20                  25                  30          


Ser Ile Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Met Trp Ala Gly Gly Gly Thr Asn Ser Asn Ser Val Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ile Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Tyr Gly Asn Ser Pro Tyr Tyr Ala Ile Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  66
<211>  113
<212>  PRT
<213>  Mus musculus

<400>  66

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Ser Met Gly Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Asp Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Gly Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  67
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  67

Glu Val Lys Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Ile Ser Asp 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu Glu Tyr Leu 
        35                  40                  45              


Gly Tyr Ile Ser Tyr Thr Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Tyr Tyr Leu 
65                  70                  75                  80  


Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Gly Gly Trp Leu Leu Pro Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  68
<211>  106
<212>  PRT
<213>  Mus musculus

<400>  68

Asp Ile Val Met Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Ile Arg Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Thr Ser Pro Lys Arg Trp Ile Ser 
        35                  40                  45              


Asp Thr Ser Lys Leu Thr Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ala Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  69
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  69

Glu Val Lys Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Arg Asp Asn Asn Thr Lys Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu His Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Thr Lys Glu Asn Trp Val Gly Asp Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Leu Ser Ser 
        115             


<210>  70
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Anti-Human B7-H1 Light Chain LC1_1

<400>  70

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile 
            20                  25                  30          


Tyr Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Ala Ala Phe Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Asn Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  71
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Anti-Human B7-H1 Light Chain LC1_2

<400>  71

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile 
            20                  25                  30          


Tyr Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Arg Pro Leu Ile Tyr 
        35                  40                  45              


Ala Ala Phe Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Asn Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  72
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Anti-Human B7-H1 Light Chain LC1_3

<400>  72

Gln Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile 
            20                  25                  30          


Tyr Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Arg Pro Leu Ile Tyr 
        35                  40                  45              


Ala Thr Phe Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Asn Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  73
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Anti-Human B7-H1 Light Chain LC2_1

<400>  73

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Gly Val Ser Tyr Ile 
            20                  25                  30          


Tyr Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ala Ala Phe Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Asn Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  74
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Anti-Human B7-H1 Light Chain LC2_2

<400>  74

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Gly Val Ser Tyr Ile 
            20                  25                  30          


Tyr Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile Tyr 
        35                  40                  45              


Ala Ala Phe Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Asn Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  75
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Anti-Human B7-H1 Light Chain LC2_3

<400>  75

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ile Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile 
            20                  25                  30          


Tyr Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile Tyr 
        35                  40                  45              


Ala Thr Phe Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Asn Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  76
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Anti-Human B7-H1 Heavy Chain HC1_1

<400>  76

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Pro Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Asp Pro Asn Tyr Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Leu Thr Asp Trp Gly Gln Gly Thr Met Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  77
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Anti-Human B7-H1 Heavy Chain HC1_2

<400>  77

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Pro Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Ser Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Asp Pro Asn Tyr Gly Gly Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Leu Thr Asp Trp Gly Gln Gly Thr Met Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  78
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Anti-Human B7-H1 Heavy Chain HC1_3

<400>  78

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Pro Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Ser Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Asp Pro Asn Tyr Gly Gly Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Val Asp Arg Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Leu Thr Asp Trp Gly Gln Gly Thr Met Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  79
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Anti-Human B7-H1 Heavy Chain HC2_1

<400>  79

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Tyr Thr Phe Pro Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Asp Ile Asp Pro Asn Tyr Gly Gly Thr Thr Tyr Ala Ala Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Val Asp Arg Ser Lys Ser Ile Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Ala Leu Thr Asp Trp Gly Gln Gly Thr Met Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  80
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Anti-Human B7-H1 Heavy Chain HC2_2

<400>  80

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Tyr Thr Phe Pro Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Asp Ile Asp Pro Asn Tyr Gly Gly Thr Thr Tyr Asn Ala Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Val Asp Arg Ser Lys Ser Ile Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Leu Thr Asp Trp Gly Gln Gly Thr Met Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  81
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Anti-Human B7-H1 Heavy Chain HC2_3

<400>  81

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Tyr Thr Phe Pro Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Asp Ile Asp Pro Asn Tyr Gly Gly Thr Thr Tyr Asn Gln Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Val Asp Arg Ser Lys Ser Ile Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Leu Thr Asp Trp Gly Gln Gly Thr Met Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  82
<211>  106
<212>  PRT
<213>  Mus musculus

<400>  82

Asp Ile Gln Met Thr Gln Phe Pro Ser Ser Leu Cys Ala Ser Gln Gly 
1               5                   10                  15      


Gly Lys Val Thr Val Thr Cys Lys Ala Ser Gln Asp Ile Asn Asn Tyr 
            20                  25                  30          


Met Ala Trp Tyr Gln His Lys Pro Gly Lys Gly Pro Arg Leu Leu Ile 
        35                  40                  45              


His Tyr Thr Ser Thr Leu Leu Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn Leu Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  83
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  83

Glu Val Gln Leu Gln Gln Ser Gly Pro Val Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Tyr Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Ile Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Ile Tyr Asp Gly Ser Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ala Leu Thr Val Ser Ser 
        115                 


<210>  84
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  84

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Ser Val Asp Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Phe Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  85
<211>  116
<212>  PRT
<213>  Mus musculus

<400>  85

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly His Ile Asn Pro Ser Ser Gly Phe Thr Thr Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Tyr Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Asp Tyr Asp Val Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  86
<211>  106
<212>  PRT
<213>  Mus musculus

<400>  86

Gln Ile Val Leu Thr Gln Ser Pro Ala Leu Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  87
<211>  122
<212>  PRT
<213>  Mus musculus

<400>  87

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Ser Tyr Thr Ile Tyr Tyr Thr Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Tyr Gly Ser Phe Tyr Glu Tyr Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120         


<210>  88
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Anti-Human PD-1 Light Chain LC1_1

<400>  88

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Leu Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  89
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Anti-Human PD-1 Light Chain LC1_2

<400>  89

Gln Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Leu Thr Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  90
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Anti-Human PD-1 Light Chain LC2_1

<400>  90

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Leu Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  91
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Anti-Human PD-1 Light Chain LC2_2

<400>  91

Gln Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  92
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Anti-Human PD-1 Heavy Chain HC1_1

<400>  92

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Tyr Gly Ser Phe Tyr Glu Tyr Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  93
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Anti-Human PD-1 Heavy Chain HC1_2

<400>  93

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Ser Tyr Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Tyr Gly Ser Phe Tyr Glu Tyr Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  94
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Anti-Human PD-1 Heavy Chain HC1_3

<400>  94

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Ser Tyr Thr Ile Tyr Ser Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Tyr Gly Ser Phe Tyr Glu Tyr Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  95
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Anti-Human PD-1 Heavy Chain HC2_1

<400>  95

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Asn Ser Ala Ser Thr Leu Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Tyr Gly Ser Phe Tyr Glu Tyr Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120         


<210>  96
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Anti-Human PD-1 Heavy Chain HC2_2

<400>  96

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Ser Ser Gly Ser Tyr Thr Ile Tyr Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Asn Ser Ala Ser Thr Leu Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Tyr Gly Ser Phe Tyr Glu Tyr Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120         


<210>  97
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Anti-Human PD-1 Heavy Chain HC2_3

<400>  97

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Ser Tyr Thr Ile Tyr Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Asn Ser Ala Ser Thr Leu Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Tyr Gly Ser Phe Tyr Glu Tyr Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120         


<210>  98
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  98

Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
1               5                   10                  15      


Thr Cys Arg Ala Ser Gln Ser Ile Asn Thr Tyr Leu Ile Trp Tyr Gln 
            20                  25                  30          


Gln Lys Pro Gly Lys Ala Pro Asn Phe Leu Ile Ser Ala Thr Ser Ile 
        35                  40                  45              


Leu Gln Ser Gly Val Pro Ser Arg Phe Arg Gly Ser Gly Ser Gly Thr 
    50                  55                  60                  


Asn Phe Thr Leu Thr Ile Asn Ser Leu His Pro Glu Asp Phe Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Phe Thr Phe Gly Pro Gly 
                85                  90                  95      


Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile 
            100                 105                 110         


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
        115                 120                 125             


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
    130                 135                 140                 


Val Asp Asn Ala Leu Gln Ser Gly 
145                 150         


<210>  99
<211>  169
<212>  PRT
<213>  Homo sapiens

<400>  99

Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser 
1               5                   10                  15      


Gly Phe Thr Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro 
            20                  25                  30          


Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Asn 
        35                  40                  45              


Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    50                  55                  60                  


Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
65                  70                  75                  80  


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Ala Arg Ile Ile Thr Pro 
                85                  90                  95      


Cys Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 
            100                 105                 110         


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser 
        115                 120                 125             


Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
    130                 135                 140                 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
145                 150                 155                 160 


Val His Thr Phe Pro Ala Val Leu Gln 
                165                 


<210>  100
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  100

Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
1               5                   10                  15      


Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Ser Phe Leu Ala Trp Tyr 
            20                  25                  30          


Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser 
        35                  40                  45              


Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    50                  55                  60                  


Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala 
65                  70                  75                  80  


Val Tyr Tyr Cys Gln Gln Tyr Gly Thr Ser Pro Trp Thr Phe Gly Gln 
                85                  90                  95      


Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe 
            100                 105                 110         


Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val 
        115                 120                 125             


Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140     


<210>  101
<211>  167
<212>  PRT
<213>  Homo sapiens

<400>  101

Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Val Ala Ser 
1               5                   10                  15      


Gly Phe Thr Phe Ser Ser His Gly Met His Trp Val Arg Gln Ala Pro 
            20                  25                  30          


Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Arg Asn 
        35                  40                  45              


Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    50                  55                  60                  


Asn Ser Lys Asn Thr Leu Phe Leu Gln Met Asn Ser Leu Arg Ala Glu 
65                  70                  75                  80  


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly His Phe Gly Pro Phe 
                85                  90                  95      


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
            100                 105                 110         


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
        115                 120                 125             


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
    130                 135                 140                 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
145                 150                 155                 160 


Thr Phe Pro Ala Val Leu Gln 
                165         


<210>  102
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  102

Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
1               5                   10                  15      


Ser Cys Arg Thr Ser Val Ser Ser Ser Tyr Leu Ala Trp Tyr Gln Gln 
            20                  25                  30          


Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg 
        35                  40                  45              


Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    50                  55                  60                  


Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr 
65                  70                  75                  80  


Tyr Cys Gln Gln Tyr Gly Ile Ser Pro Phe Thr Phe Gly Gly Gly Thr 
                85                  90                  95      


Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
            100                 105                 110         


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
        115                 120                 125             


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln 
    130                 135                 140     


<210>  103
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  103

Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Thr Ala Ser 
1               5                   10                  15      


Gly Phe Thr Phe Ser Asn Tyr Gly Met His Trp Val Arg Gln Ala Pro 
            20                  25                  30          


Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Asn 
        35                  40                  45              


Lys His Tyr Gly Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ser Asp 
    50                  55                  60                  


Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
65                  70                  75                  80  


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Glu Arg Leu Gly Ser Tyr 
                85                  90                  95      


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
            100                 105                 110         


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr 
        115                 120                 125             


Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
    130                 135                 140                 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
145                 150                 155                 160 


His Thr Phe Pro Ala Val 
                165     


<210>  104
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  104

Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 
1               5                   10                  15      


Cys Arg Ala Ser Gln Ser Ile Ser Ser Asn Phe Leu Ala Trp Tyr Gln 
            20                  25                  30          


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Arg Pro Ser Ser 
        35                  40                  45              


Arg Ala Thr Gly Ile Pro Asp Ser Phe Ser Gly Ser Gly Ser Gly Thr 
    50                  55                  60                  


Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Leu 
65                  70                  75                  80  


Tyr Tyr Cys Gln Gln Tyr Gly Thr Ser Pro Phe Thr Phe Gly Pro Gly 
                85                  90                  95      


Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile 
            100                 105                 110         


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
        115                 120                 125             


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln 
    130                 135                 140         


<210>  105
<211>  167
<212>  PRT
<213>  Homo sapiens

<400>  105

Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Val Ala Ser 
1               5                   10                  15      


Gly Phe Ile Phe Ser Ser His Gly Ile His Trp Val Arg Gln Ala Pro 
            20                  25                  30          


Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Arg Asn 
        35                  40                  45              


Lys Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    50                  55                  60                  


Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
65                  70                  75                  80  


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Val Ala Pro Leu Gly Pro Leu 
                85                  90                  95      


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
            100                 105                 110         


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
        115                 120                 125             


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
    130                 135                 140                 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
145                 150                 155                 160 


Thr Phe Pro Ala Val Leu Gln 
                165         


<210>  106
<211>  139
<212>  PRT
<213>  Homo sapiens

<400>  106

Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg 
1               5                   10                  15      


Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro 
            20                  25                  30          


Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr 
        35                  40                  45              


Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
    50                  55                  60                  


Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
65                  70                  75                  80  


Gln Gln Tyr Gly Arg Ser Pro Phe Thr Phe Gly Pro Gly Thr Lys Val 
                85                  90                  95      


Asp Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
            100                 105                 110         


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
        115                 120                 125             


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln 
    130                 135                 


<210>  107
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  107

Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
1               5                   10                  15      


Ser Ser His Gly Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            20                  25                  30          


Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Arg Asn Lys Asp Tyr Ala 
        35                  40                  45              


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys 
    50                  55                  60                  


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
65                  70                  75                  80  


Tyr Tyr Cys Ala Arg Val Ala Pro Leu Gly Pro Leu Asp Tyr Trp Gly 
                85                  90                  95      


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
            100                 105                 110         


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
        115                 120                 125             


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
    130                 135                 140                 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
145                 150                 155                 160 


Val Leu Gln 
            


<210>  108
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  108

Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
1               5                   10                  15      


Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln 
            20                  25                  30          


Gln Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile Tyr Gly Val Ser Ser 
        35                  40                  45              


Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    50                  55                  60                  


Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val 
65                  70                  75                  80  


Tyr Tyr Cys Gln Gln Tyr Gly Ile Ser Pro Phe Thr Phe Gly Pro Gly 
                85                  90                  95      


Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile 
            100                 105                 110         


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
        115                 120                 125             


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln 
    130                 135                 140         


<210>  109
<211>  138
<212>  PRT
<213>  Homo sapiens

<400>  109

Gly Gly Val Val Glu Pro Gly Arg Ser Leu Arg Leu Ser Cys Thr Ala 
1               5                   10                  15      


Ser Gly Phe Thr Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala 
            20                  25                  30          


Pro Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser 
        35                  40                  45              


Asn Lys His Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg 
    50                  55                  60                  


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
65                  70                  75                  80  


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ala Gly Leu Leu Gly Tyr 
                85                  90                  95      


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
            100                 105                 110         


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr 
        115                 120                 125             


Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
    130                 135             


<210>  110
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  110

Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
1               5                   10                  15      


Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln 
            20                  25                  30          


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser 
        35                  40                  45              


Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    50                  55                  60                  


Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val 
65                  70                  75                  80  


Tyr Tyr Cys Gln Gln Tyr Gly Arg Ser Pro Phe Thr Phe Gly Pro Gly 
                85                  90                  95      


Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile 
            100                 105                 110         


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
        115                 120                 125             


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
    130                 135                 140                 


Gly Gly 
145     


<210>  111
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  111

Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
1               5                   10                  15      


Ser Ser His Gly Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            20                  25                  30          


Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Arg Asn Lys Asp Tyr Ala 
        35                  40                  45              


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
    50                  55                  60                  


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
65                  70                  75                  80  


Tyr Tyr Cys Ala Arg Val Ala Pro Leu Gly Pro Leu Asp Tyr Trp Gly 
                85                  90                  95      


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
            100                 105                 110         


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
        115                 120                 125             


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
    130                 135                 140                 


Ser Trp Asn Ser Gly Ala Leu Thr Ser 
145                 150             


<210>  112
<211>  139
<212>  PRT
<213>  Homo sapiens

<400>  112

Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
1               5                   10                  15      


Arg Ala Ser Gln Ser Ile Asn Ser Tyr Leu Asp Trp Tyr Gln Gln Lys 
            20                  25                  30          


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
        35                  40                  45              


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
    50                  55                  60                  


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
65                  70                  75                  80  


Cys Gln Gln Tyr Tyr Ser Thr Pro Phe Thr Phe Gly Pro Gly Thr Lys 
                85                  90                  95      


Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
            100                 105                 110         


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
        115                 120                 125             


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 
    130                 135                 


<210>  113
<211>  167
<212>  PRT
<213>  Homo sapiens

<400>  113

Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser 
1               5                   10                  15      


Gly Phe Thr Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro 
            20                  25                  30          


Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Asn 
        35                  40                  45              


Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    50                  55                  60                  


Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
65                  70                  75                  80  


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Pro Arg Gly Ala Thr Leu 
                85                  90                  95      


Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His 
                165         


<210>  114
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  114

Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
1               5                   10                  15      


Ile Thr Cys Arg Ala Ser Gln Asn Ile Ser Arg Tyr Leu Asn Trp Tyr 
            20                  25                  30          


Gln Gln Lys Pro Gly Lys Ala Pro Lys Phe Leu Ile Tyr Val Ala Ser 
        35                  40                  45              


Ile Leu Gln Ser Gly Val Pro Ser Gly Phe Ser Ala Ser Gly Ser Gly 
    50                  55                  60                  


Pro Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
65                  70                  75                  80  


Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Phe Thr Phe Gly Pro 
                85                  90                  95      


Gly Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe 
            100                 105                 110         


Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val 
        115                 120                 125             


Val Cys Leu Leu Asn Asn 
    130                 


<210>  115
<211>  150
<212>  PRT
<213>  Homo sapiens

<400>  115

Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser 
1               5                   10                  15      


Gly Phe Thr Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro 
            20                  25                  30          


Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser His 
        35                  40                  45              


Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    50                  55                  60                  


Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
65                  70                  75                  80  


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Ala Val Val Val Pro Ala 
                85                  90                  95      


Ala Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 
            100                 105                 110         


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser 
        115                 120                 125             


Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
    130                 135                 140                 


Pro Glu Pro Val Thr Val 
145                 150 


<210>  116
<211>  150
<212>  PRT
<213>  Homo sapiens

<400>  116

Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
1               5                   10                  15      


Ile Thr Cys Arg Ala Ser Gln Ser Ile Cys Asn Tyr Leu Asn Trp Tyr 
            20                  25                  30          


Gln Gln Lys Pro Gly Lys Ala Pro Arg Val Leu Ile Tyr Ala Ala Ser 
        35                  40                  45              


Ser Leu Gln Gly Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
    50                  55                  60                  


Ile Asp Cys Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
65                  70                  75                  80  


Thr Tyr Tyr Cys Gln Gln Ser Tyr Ile Thr Pro Phe Thr Phe Gly Pro 
                85                  90                  95      


Gly Thr Arg Val Asp Ile Glu Arg Thr Val Ala Ala Pro Ser Val Phe 
            100                 105                 110         


Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val 
        115                 120                 125             


Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp 
    130                 135                 140                 


Lys Val Asp Asn Ala Tyr 
145                 150 


<210>  117
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  117

Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
1               5                   10                  15      


Phe Thr Phe Ser Ser Cys Gly Met His Trp Val Arg Gln Ala Pro Gly 
            20                  25                  30          


Lys Gly Leu Glu Trp Val Ala Val Ile Trp Ser Asp Gly Ser His Lys 
        35                  40                  45              


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    50                  55                  60                  


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
65                  70                  75                  80  


Thr Ala Val Tyr Tyr Cys Ala Arg Gly Thr Met Ile Val Val Gly Thr 
                85                  90                  95      


Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
            100                 105                 110         


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr 
        115                 120                 125             


Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
    130                 135                 140                 


Glu Pro 
145     


<210>  118
<211>  139
<212>  PRT
<213>  Homo sapiens

<400>  118

Pro Leu Ser Leu Pro Val Thr Leu Gly Gln Pro Ala Ser Ile Ser Cys 
1               5                   10                  15      


Arg Ser Ser Gln Ser Leu Val Tyr Ser Asp Gly Asn Thr Tyr Leu Asn 
            20                  25                  30          


Trp Phe Gln Gln Arg Pro Gly Gln Ser Pro Arg Arg Leu Ile Tyr Lys 
        35                  40                  45              


Val Ser Asn Trp Asp Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly 
    50                  55                  60                  


Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp 
65                  70                  75                  80  


Val Gly Val Tyr Tyr Cys Met Gln Gly Ser His Trp Pro Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser 
            100                 105                 110         


Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 
        115                 120                 125             


Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 


<210>  119
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  119

Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser 
1               5                   10                  15      


Gly Phe Thr Phe Ser Ser Tyr Gly Val His Trp Val Arg Gln Ala Pro 
            20                  25                  30          


Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Asn 
        35                  40                  45              


Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    50                  55                  60                  


Asn Ser Lys Ser Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
65                  70                  75                  80  


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Ser Tyr Tyr Asp Phe Trp 
                85                  90                  95      


Ser Gly Arg Gly Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170     


<210>  120
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  120

Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu 
1               5                   10                  15      


His Ser Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly 
            20                  25                  30          


Gln Ser Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly 
        35                  40                  45              


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
    50                  55                  60                  


Lys Leu Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met 
65                  70                  75                  80  


Gln Ala Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu 
                85                  90                  95      


Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 
            100                 105                 110         


Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn 
        115                 120                 125             


Asn Phe Tyr Pro Arg 
    130             


<210>  121
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  121

Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
1               5                   10                  15      


Thr Phe Ser Asn Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys 
            20                  25                  30          


Gly Leu Glu Trp Val Val Val Ile Trp His Asp Gly Asn Asn Lys Tyr 
        35                  40                  45              


Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
    50                  55                  60                  


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
65                  70                  75                  80  


Ala Val Tyr Tyr Cys Ala Arg Asp Gln Gly Thr Gly Trp Tyr Gly Gly 
                85                  90                  95      


Phe Asp Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
            100                 105                 110         


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr 
        115                 120                 125             


Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
    130                 135                 140                 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
145                 150                 155                 160 


His Thr Phe 
            


