                         SEQUENCE LISTING

<110>  Technische Universitt Dresden
 
<120>  New fusion gene as therapeutic target in proliferative diseases

<130>  TUD105WO

<150>  EP 14 152 417.3
<151>  2014-01-24

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  2352
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Thr Ser Arg Thr Lys Arg Arg Gln Lys Val Lys Ile Ser Ile Ser 
1               5                   10                  15      


Lys Ile Asn His Ser Ser Tyr Arg Lys Glu His Arg Pro Phe Trp Glu 
            20                  25                  30          


His Gln Pro Pro Pro His Gln Asn Trp Ala Val Gly Gly Arg Cys Gly 
        35                  40                  45              


Ala Gly Ala Arg Pro Gly Leu Ser Gln Arg Arg Gly Arg Glu Val Arg 
    50                  55                  60                  


Arg Glu Ala Gln Gly Gly Ala Ser Ser Arg Arg Leu Arg Ala Arg Leu 
65                  70                  75                  80  


Tyr Phe Ser Glu Ser Thr Ser Leu Pro Leu Asp Arg Arg Gly Ser Pro 
                85                  90                  95      


Gly Pro Leu Gly Pro Ala Pro His Gly Leu Arg Arg Ala Ala Pro Arg 
            100                 105                 110         


Gly Pro Ala Arg Arg Thr Pro Arg Ser Thr Ala Leu Thr Ser Arg Arg 
        115                 120                 125             


Arg Ala Gln Arg Pro Arg His Gly Asp Arg Leu Arg Leu Arg Ser Glu 
    130                 135                 140                 


Ala Arg Pro Arg Ala Ala Gly Asp Trp Pro Cys Ala Arg Gly Gly Ala 
145                 150                 155                 160 


Val Arg Pro Gly Arg Pro His Arg Pro Pro Arg Val Glu Ser Ala Arg 
                165                 170                 175     


Gly Ala His Ala Gly Arg Ala Ala Thr Asp Gln Leu Glu Arg Val Phe 
            180                 185                 190         


Leu Arg Leu Gly His Ala Glu Thr Asp Glu Gln Leu Gln Asn Ile Ile 
        195                 200                 205             


Ser Lys Phe Leu Pro Pro Val Leu Leu Lys Leu Ser Ser Thr Gln Glu 
    210                 215                 220                 


Gly Val Arg Lys Lys Val Met Glu Leu Leu Val His Leu Asn Lys Arg 
225                 230                 235                 240 


Ile Lys Ser Arg Pro Lys Ile Gln Leu Pro Val Glu Thr Leu Leu Val 
                245                 250                 255     


Gln Tyr Gln Asp Pro Ala Ala Val Ser Phe Val Thr Asn Phe Thr Ile 
            260                 265                 270         


Ile Tyr Val Lys Met Gly Tyr Pro Arg Leu Pro Val Glu Lys Gln Cys 
        275                 280                 285             


Glu Leu Ala Pro Thr Leu Leu Thr Ala Met Glu Gly Lys Pro Gln Pro 
    290                 295                 300                 


Gln Gln Asp Ser Leu Met His Leu Leu Ile Pro Thr Leu Phe His Met 
305                 310                 315                 320 


Lys Tyr Pro Val Glu Ser Ser Lys Ser Ala Ser Pro Phe Asn Leu Ala 
                325                 330                 335     


Glu Lys Pro Lys Thr Val Gln Leu Leu Leu Asp Phe Met Leu Asp Val 
            340                 345                 350         


Leu Leu Met Pro Tyr Gly Tyr Val Leu Asn Glu Ser Gln Ser Arg Gln 
        355                 360                 365             


Asn Ser Ser Ser Ala Gln Gly Ser Ser Ser Asn Ser Gly Gly Gly Ser 
    370                 375                 380                 


Gly Ile Pro Gln Pro Pro Pro Gly Met Ser Phe Tyr Ala Ala Lys Arg 
385                 390                 395                 400 


Val Ile Gly Asp Asn Pro Trp Thr Pro Glu Gln Leu Glu Gln Cys Lys 
                405                 410                 415     


Leu Gly Ile Val Lys Phe Ile Glu Ala Glu Gln Val Pro Glu Leu Glu 
            420                 425                 430         


Ala Val Leu His Leu Val Ile Ala Ser Ser Asp Thr Arg His Ser Val 
        435                 440                 445             


Ala Thr Ala Ala Asp Leu Glu Leu Lys Ser Lys Gln Ser Leu Ile Asp 
    450                 455                 460                 


Trp Asn Asn Pro Ala Ile Ile Asn Lys Met Tyr Lys Val Tyr Leu Gly 
465                 470                 475                 480 


Asp Ile Pro Leu Lys Thr Lys Glu Gly Ala Val Leu Lys Pro Glu Leu 
                485                 490                 495     


Lys Arg Asp Pro Val Ser Thr Arg Val Lys Leu Lys Ile Val Pro His 
            500                 505                 510         


Leu Leu Arg Ser Arg Gln Ala Ala Glu Thr Phe Pro Ala Asn Ile Gln 
        515                 520                 525             


Val Val Tyr Asp Gly Leu Phe Gly Thr Asn Thr Asn Ser Lys Leu Arg 
    530                 535                 540                 


Thr Leu Ser Leu Gln Phe Val His His Ile Cys Ile Thr Cys Pro Glu 
545                 550                 555                 560 


Ile Lys Ile Lys Pro Leu Gly Pro Met Leu Leu Asn Gly Leu Thr Lys 
                565                 570                 575     


Leu Ile Asn Glu Tyr Lys Glu Asp Pro Lys Leu Leu Ser Met Ala Tyr 
            580                 585                 590         


Ser Ala Val Gly Lys Leu Ser Ser Arg Met Pro His Leu Phe Thr Lys 
        595                 600                 605             


Asp Ile Ala Leu Val Gln Gln Leu Phe Glu Ala Leu Cys Lys Glu Glu 
    610                 615                 620                 


Pro Glu Thr Arg Leu Ala Ile Gln Glu Ala Leu Ser Met Met Val Gly 
625                 630                 635                 640 


Ala Tyr Ser Thr Leu Glu Gly Ala Gln Arg Thr Leu Met Glu Ala Leu 
                645                 650                 655     


Val Ala Ser Tyr Leu Ile Lys Pro Glu Val Gln Val Arg Gln Val Ala 
            660                 665                 670         


Val Lys Phe Ala Ser Thr Val Phe Pro Ser Asp His Ile Pro Ser Arg 
        675                 680                 685             


Tyr Leu Leu Leu Leu Ala Ala Gly Asp Pro Arg Glu Glu Val His Gly 
    690                 695                 700                 


Glu Ala Gln Arg Val Leu Arg Cys Leu Pro Gly Arg Asn Arg Lys Glu 
705                 710                 715                 720 


Ser Thr Ser Glu Gln Met Pro Ser Phe Pro Glu Met Val Tyr Tyr Ile 
                725                 730                 735     


Gln Glu Lys Ala Ser His Arg Met Lys Thr Pro Val Lys Tyr Met Thr 
            740                 745                 750         


Gly Thr Thr Val Leu Pro Phe Asn Pro Ala Ala Phe Gly Glu Ile Val 
        755                 760                 765             


Leu Tyr Leu Arg Met Cys Leu Ala His Ser Ala Gly Val Val Pro Thr 
    770                 775                 780                 


Ser Gln Ser Leu Ala Asp Met Gln Asp His Ala Pro Ala Ile Gly Arg 
785                 790                 795                 800 


Tyr Ile Arg Thr Leu Met Ser Ser Gly Gln Met Ala Pro Ser Ser Ser 
                805                 810                 815     


Asn Lys Ser Gly Glu Thr Asn Pro Val Gln Ile Tyr Ile Gly Leu Leu 
            820                 825                 830         


Gln Gln Leu Leu Ala Gly Val Gly Gly Leu Pro Val Met Tyr Cys Leu 
        835                 840                 845             


Leu Glu Ala Val Ser Val Tyr Pro Glu Lys Leu Ala Thr Lys Phe Val 
    850                 855                 860                 


Asp Lys Thr Glu Trp Ile Lys Ser Leu Met Asn Asn Ser Lys Glu Glu 
865                 870                 875                 880 


Met Arg Glu Leu Ala Ala Leu Phe Tyr Ser Val Val Val Ser Thr Val 
                885                 890                 895     


Ser Gly Asn Glu Leu Lys Ser Met Ile Glu Gln Leu Ile Lys Thr Thr 
            900                 905                 910         


Lys Asp Asn His Ser Pro Glu Ile Gln His Gly Ser Leu Leu Ala Leu 
        915                 920                 925             


Gly Phe Thr Val Gly Arg Tyr Leu Ala Lys Lys Lys Met Arg Met Ser 
    930                 935                 940                 


Glu Gln Gln Asp Leu Glu Arg Asn Ala Asp Thr Leu Pro Asp Gln Glu 
945                 950                 955                 960 


Glu Leu Ile Gln Ser Ala Thr Glu Thr Ile Gly Ser Phe Leu Asp Ser 
                965                 970                 975     


Thr Ser Pro Leu Leu Ala Ile Ala Ala Cys Thr Ala Leu Gly Glu Ile 
            980                 985                 990         


Gly Arg Asn Gly Pro Leu Pro Ile  Pro Ser Glu Gly Ser  Gly Phe Thr 
        995                 1000                 1005             


Lys Leu  His Leu Val Glu Ser  Leu Leu Ser Arg Ile  Pro Ser Ser 
    1010                 1015                 1020             


Lys Glu  Thr Asn Lys Met Lys  Glu Arg Ala Ile Gln  Thr Leu Gly 
    1025                 1030                 1035             


Tyr Phe  Pro Val Gly Asp Gly  Asp Phe Pro His Gln  Lys Leu Leu 
    1040                 1045                 1050             


Leu Gln  Gly Leu Met Asp Ser  Val Glu Ala Lys Gln  Ile Glu Leu 
    1055                 1060                 1065             


Gln Phe  Thr Ile Gly Glu Ala  Ile Thr Ser Ala Ala  Ile Gly Thr 
    1070                 1075                 1080             


Ser Ser  Val Ala Ala Arg Asp  Ala Trp Gln Met Thr  Glu Glu Glu 
    1085                 1090                 1095             


Tyr Thr  Pro Pro Ala Val Leu  Arg Asp Asp Phe Arg  Gln Asn Pro 
    1100                 1105                 1110             


Thr Asp  Val Val Val Ala Ala  Gly Glu Pro Ala Ile  Leu Glu Cys 
    1115                 1120                 1125             


Gln Pro  Pro Arg Gly His Pro  Glu Pro Thr Ile Tyr  Trp Lys Lys 
    1130                 1135                 1140             


Asp Lys  Val Arg Ile Asp Asp  Lys Glu Glu Arg Ile  Ser Ile Arg 
    1145                 1150                 1155             


Gly Gly  Lys Leu Met Ile Ser  Asn Thr Arg Lys Ser  Asp Ala Gly 
    1160                 1165                 1170             


Met Tyr  Thr Cys Val Gly Thr  Asn Met Val Gly Glu  Arg Asp Ser 
    1175                 1180                 1185             


Asp Pro  Ala Glu Leu Thr Val  Phe Glu Arg Pro Thr  Phe Leu Arg 
    1190                 1195                 1200             


Arg Pro  Ile Asn Gln Val Val  Leu Glu Glu Glu Ala  Val Glu Phe 
    1205                 1210                 1215             


Arg Cys  Gln Val Gln Gly Asp  Pro Gln Pro Thr Val  Arg Trp Lys 
    1220                 1225                 1230             


Lys Asp  Asp Ala Asp Leu Pro  Arg Gly Arg Tyr Asp  Ile Lys Asp 
    1235                 1240                 1245             


Asp Tyr  Thr Leu Arg Ile Lys  Lys Thr Met Ser Thr  Asp Glu Gly 
    1250                 1255                 1260             


Thr Tyr  Met Cys Ile Ala Glu  Asn Arg Val Gly Lys  Met Glu Ala 
    1265                 1270                 1275             


Ser Ala  Thr Leu Thr Val Arg  Ala Pro Pro Gln Phe  Val Val Arg 
    1280                 1285                 1290             


Pro Arg  Asp Gln Ile Val Ala  Gln Gly Arg Thr Val  Thr Phe Pro 
    1295                 1300                 1305             


Cys Glu  Thr Lys Gly Asn Pro  Gln Pro Ala Val Phe  Trp Gln Lys 
    1310                 1315                 1320             


Glu Gly  Ser Gln Asn Leu Leu  Phe Pro Asn Gln Pro  Gln Gln Pro 
    1325                 1330                 1335             


Asn Ser  Arg Cys Ser Val Ser  Pro Thr Gly Asp Leu  Thr Ile Thr 
    1340                 1345                 1350             


Asn Ile  Gln Arg Ser Asp Ala  Gly Tyr Tyr Ile Cys  Gln Ala Leu 
    1355                 1360                 1365             


Thr Val  Ala Gly Ser Ile Leu  Ala Lys Ala Gln Leu  Glu Val Thr 
    1370                 1375                 1380             


Asp Val  Leu Thr Asp Arg Pro  Pro Pro Ile Ile Leu  Gln Gly Pro 
    1385                 1390                 1395             


Ala Asn  Gln Thr Leu Ala Val  Asp Gly Thr Ala Leu  Leu Lys Cys 
    1400                 1405                 1410             


Lys Ala  Thr Gly Asp Pro Leu  Pro Val Ile Ser Trp  Leu Lys Glu 
    1415                 1420                 1425             


Gly Phe  Thr Phe Pro Gly Arg  Asp Pro Arg Ala Thr  Ile Gln Glu 
    1430                 1435                 1440             


Gln Gly  Thr Leu Gln Ile Lys  Asn Leu Arg Ile Ser  Asp Thr Gly 
    1445                 1450                 1455             


Thr Tyr  Thr Cys Val Ala Thr  Ser Ser Ser Gly Glu  Thr Ser Trp 
    1460                 1465                 1470             


Ser Ala  Val Leu Asp Val Thr  Glu Ser Gly Ala Thr  Ile Ser Lys 
    1475                 1480                 1485             


Asn Tyr  Asp Leu Ser Asp Leu  Pro Gly Pro Pro Ser  Lys Pro Gln 
    1490                 1495                 1500             


Val Thr  Asp Val Thr Lys Asn  Ser Val Thr Leu Ser  Trp Gln Pro 
    1505                 1510                 1515             


Gly Thr  Pro Gly Thr Leu Pro  Ala Ser Ala Tyr Ile  Ile Glu Ala 
    1520                 1525                 1530             


Phe Ser  Gln Ser Val Ser Asn  Ser Trp Gln Thr Val  Ala Asn His 
    1535                 1540                 1545             


Val Lys  Thr Thr Leu Tyr Thr  Val Arg Gly Leu Arg  Pro Asn Thr 
    1550                 1555                 1560             


Ile Tyr  Leu Phe Met Val Arg  Ala Ile Asn Pro Gln  Gly Leu Ser 
    1565                 1570                 1575             


Asp Pro  Ser Pro Met Ser Asp  Pro Val Arg Thr Gln  Asp Ile Ser 
    1580                 1585                 1590             


Pro Pro  Ala Gln Gly Val Asp  His Arg Gln Val Gln  Lys Glu Leu 
    1595                 1600                 1605             


Gly Asp  Val Leu Val Arg Leu  His Asn Pro Val Val  Leu Thr Pro 
    1610                 1615                 1620             


Thr Thr  Val Gln Val Thr Trp  Thr Val Asp Arg Gln  Pro Gln Phe 
    1625                 1630                 1635             


Ile Gln  Gly Tyr Arg Val Met  Tyr Arg Gln Thr Ser  Gly Leu Gln 
    1640                 1645                 1650             


Ala Thr  Ser Ser Trp Gln Asn  Leu Asp Ala Lys Val  Pro Thr Glu 
    1655                 1660                 1665             


Arg Ser  Ala Val Leu Val Asn  Leu Lys Lys Gly Val  Thr Tyr Glu 
    1670                 1675                 1680             


Ile Lys  Val Arg Pro Tyr Phe  Asn Glu Phe Gln Gly  Met Asp Ser 
    1685                 1690                 1695             


Glu Ser  Lys Thr Val Arg Thr  Thr Glu Glu Ala Pro  Ser Ala Pro 
    1700                 1705                 1710             


Pro Gln  Ser Val Thr Val Leu  Thr Val Gly Ser Tyr  Asn Ser Thr 
    1715                 1720                 1725             


Ser Ile  Ser Val Ser Trp Asp  Pro Pro Pro Pro Asp  His Gln Asn 
    1730                 1735                 1740             


Gly Ile  Ile Gln Glu Tyr Lys  Ile Trp Cys Leu Gly  Asn Glu Thr 
    1745                 1750                 1755             


Arg Phe  His Ile Asn Lys Thr  Val Asp Ala Ala Ile  Arg Ser Val 
    1760                 1765                 1770             


Ile Ile  Gly Gly Leu Phe Pro  Gly Ile Gln Tyr Arg  Val Glu Val 
    1775                 1780                 1785             


Ala Ala  Ser Thr Ser Ala Gly  Val Gly Val Lys Ser  Glu Pro Gln 
    1790                 1795                 1800             


Pro Ile  Ile Ile Gly Arg Arg  Asn Glu Val Val Ile  Thr Glu Asn 
    1805                 1810                 1815             


Asn Asn  Ser Ile Thr Glu Gln  Ile Thr Asp Val Val  Lys Gln Pro 
    1820                 1825                 1830             


Ala Phe  Ile Ala Gly Ile Gly  Gly Ala Cys Trp Val  Ile Leu Met 
    1835                 1840                 1845             


Gly Phe  Ser Ile Trp Leu Tyr  Trp Arg Arg Lys Lys  Arg Lys Gly 
    1850                 1855                 1860             


Leu Ser  Asn Tyr Ala Val Thr  Phe Gln Arg Gly Asp  Gly Gly Leu 
    1865                 1870                 1875             


Met Ser  Asn Gly Ser Arg Pro  Gly Leu Leu Asn Ala  Gly Asp Pro 
    1880                 1885                 1890             


Ser Tyr  Pro Trp Leu Ala Asp  Ser Trp Pro Ala Thr  Ser Leu Pro 
    1895                 1900                 1905             


Val Asn  Asn Ser Asn Ser Gly  Pro Asn Glu Ile Gly  Asn Phe Gly 
    1910                 1915                 1920             


Arg Gly  Asp Val Leu Pro Pro  Val Pro Gly Gln Gly  Asp Lys Thr 
    1925                 1930                 1935             


Ala Thr  Met Leu Ser Asp Gly  Ala Ile Tyr Ser Ser  Ile Asp Phe 
    1940                 1945                 1950             


Thr Thr  Lys Thr Ser Tyr Asn  Ser Ser Ser Gln Ile  Thr Gln Ala 
    1955                 1960                 1965             


Thr Pro  Tyr Ala Thr Thr Gln  Ile Leu His Ser Asn  Ser Ile His 
    1970                 1975                 1980             


Glu Leu  Ala Val Asp Leu Pro  Asp Pro Gln Trp Lys  Ser Ser Ile 
    1985                 1990                 1995             


Gln Gln  Lys Thr Asp Leu Met  Gly Phe Gly Tyr Ser  Leu Pro Asp 
    2000                 2005                 2010             


Gln Asn  Lys Gly Asn Asn Gly  Gly Lys Gly Gly Lys  Lys Lys Lys 
    2015                 2020                 2025             


Asn Lys  Asn Ser Ser Lys Pro  Gln Lys Asn Asn Gly  Ser Thr Trp 
    2030                 2035                 2040             


Ala Asn  Val Pro Leu Pro Pro  Pro Pro Val Gln Pro  Leu Pro Gly 
    2045                 2050                 2055             


Thr Glu  Leu Glu His Tyr Ala  Val Glu Gln Gln Glu  Asn Gly Tyr 
    2060                 2065                 2070             


Asp Ser  Asp Ser Trp Cys Pro  Pro Leu Pro Val Gln  Thr Tyr Leu 
    2075                 2080                 2085             


His Gln  Gly Leu Glu Asp Glu  Leu Glu Glu Asp Asp  Asp Arg Val 
    2090                 2095                 2100             


Pro Thr  Pro Pro Val Arg Gly  Val Ala Ser Ser Pro  Ala Ile Ser 
    2105                 2110                 2115             


Phe Gly  Gln Gln Ser Thr Ala  Thr Leu Thr Pro Ser  Pro Arg Glu 
    2120                 2125                 2130             


Glu Met  Gln Pro Met Leu Gln  Ala His Leu Asp Glu  Leu Thr Arg 
    2135                 2140                 2145             


Ala Tyr  Gln Phe Asp Ile Ala  Lys Gln Thr Trp His  Ile Gln Ser 
    2150                 2155                 2160             


Asn Asn  Gln Pro Pro Gln Pro  Pro Val Pro Pro Leu  Gly Tyr Val 
    2165                 2170                 2175             


Ser Gly  Ala Leu Ile Ser Asp  Leu Glu Thr Asp Val  Ala Asp Asp 
    2180                 2185                 2190             


Asp Ala  Asp Asp Glu Glu Glu  Ala Leu Glu Ile Pro  Arg Pro Leu 
    2195                 2200                 2205             


Arg Ala  Leu Asp Gln Thr Pro  Gly Ser Ser Met Asp  Asn Leu Asp 
    2210                 2215                 2220             


Ser Ser  Val Thr Gly Lys Ala  Phe Thr Ser Ser Gln  Arg Pro Arg 
    2225                 2230                 2235             


Pro Thr  Ser Pro Phe Ser Thr  Asp Ser Asn Thr Ser  Ala Ala Leu 
    2240                 2245                 2250             


Ser Gln  Ser Gln Arg Pro Arg  Pro Thr Lys Lys His  Lys Gly Gly 
    2255                 2260                 2265             


Arg Met  Asp Gln Gln Pro Ala  Leu Pro His Arg Arg  Glu Gly Met 
    2270                 2275                 2280             


Thr Asp  Glu Glu Ala Leu Val  Pro Tyr Ser Lys Pro  Ser Phe Pro 
    2285                 2290                 2295             


Ser Pro  Gly Gly His Ser Ser  Ser Gly Thr Ala Ser  Ser Lys Gly 
    2300                 2305                 2310             


Ser Thr  Gly Pro Arg Lys Thr  Glu Val Leu Arg Ala  Gly His Gln 
    2315                 2320                 2325             


Arg Asn  Ala Ser Asp Leu Leu  Asp Ile Gly Tyr Met  Gly Ser Asn 
    2330                 2335                 2340             


Ser Gln  Gly Gln Phe Thr Gly  Glu Leu 
    2345                 2350         


<210>  2
<211>  7059
<212>  DNA
<213>  Homo sapiens

<400>  2
atgacctcac ggacaaagcg aaggcagaaa gttaaaatca gcatatcgaa aataaatcac       60

tctagttacc gaaaagaaca taggccgttt tgggagcacc agccacctcc acaccagaac      120

tgggctgtcg ggggccgctg cggcgcaggg gctcgtccgg gactgagtca gcgccggggc      180

cgagaagttc ggcgggaggc gcagggcggg gcttcctccc gccgactccg agcccggctc      240

tacttttctg agtccacgtc tcttcctttg gacaggcgtg gcagcccggg cccgctcggc      300

ccagcccctc acggactgcg gcgcgcggct ccccggggcc cggcccgccg aacgcctcgc      360

tctacagccc tcacctcgcg gcgccgagcg cagcgtccgc ggcatggaga ccggctccga      420

ctcaggtcag aggcccgccc ccgggccgcg ggggactggc cctgcgcgcg cggcggcgcg      480

gttaggccgg gccgcccgca caggccgccg cgtgtcgagt ccgcgcgggg agcgcacgcg      540

gggcgggcgg cgacagatca gcttgaacgg gtctttttac gacttggcca tgctgaaaca      600

gatgaacaat tacagaatat tatatctaaa ttccttcctc ctgttttgct caaactctct      660

agcacccaag aaggagtacg taaaaaggta atggaactgc tggtccatct gaataaacgt      720

ataaaaagcc gccccaaaat acaacttcca gtagagacac tgttggttca gtaccaggac      780

cctgctgcag tttcctttgt cacaaatttt actataattt atgttaaaat gggctatcct      840

cgcctaccag tggaaaaaca atgtgaactg gcccctacgc ttcttactgc catggaaggg      900

aagcctcagc cacagcagga tagcttaatg catcttttaa taccaaccct ttttcacatg      960

aaataccctg ttgaatcatc aaaatcagct tctccattta atcttgctga gaaaccaaag     1020

actgtgcagc tgcttttgga cttcatgcta gatgtccttc tgatgcctta tggttacgtg     1080

ttaaatgaat cccagagtcg ccaaaattca tcttcagcac agggttcttc ttcaaacagt     1140

ggcggaggtt ctggaatccc acagcctcct ccgggaatga gcttttatgc agccaaacga     1200

gttattggtg ataacccatg gacacctgaa caattggaac agtgcaaatt gggaatcgtg     1260

aaattcatag aagctgaaca ggtgcctgaa cttgaagctg ttctccactt ggtgattgcc     1320

tctagtgata cacgccacag tgtggcaacg gcagcagacc tggaattgaa aagcaaacag     1380

agcttaattg actggaataa tcctgccatc attaataaga tgtacaaggt gtaccttgga     1440

gatataccac tgaagacaaa agagggtgca gttctgaagc cagagttgaa aagggaccct     1500

gtcagtacaa gagtcaagtt aaagattgtc ccccatctcc tccgctctag acaagctgct     1560

gaaacgttcc cagccaacat tcaggtggtg tatgatggac tttttggtac aaatacaaat     1620

tcaaagttaa gaacattatc cctgcaattt gtgcatcata tttgtataac ctgtccagaa     1680

atcaagatta agccattagg tccaatgctt ttgaatggcc tcaccaagct aatcaatgaa     1740

tacaaagagg accctaaact actgtcaatg gcatattcag ctgttggaaa actctccagt     1800

cggatgccac atttattcac taaggatata gcgcttgtgc agcagctttt tgaagccctt     1860

tgcaaggaag agcctgagac tcgacttgct attcaagaag ctttatctat gatggttgga     1920

gcgtatagta ctttggaagg ggcacagcga actctcatgg aggcacttgt ggcttcgtac     1980

ttaataaagc ctgaagttca agttcgacaa gtggctgtga aatttgccag tacggtgttt     2040

ccctcagatc atatcccttc cagatatttg ctgctactgg ctgcaggaga tccacgtgaa     2100

gaagttcatg gagaagcaca acgcgtatta aggtgtcttc caggtagaaa cagaaaagaa     2160

agtacttctg agcagatgcc ttccttccca gaaatggttt attacatcca agaaaaggct     2220

tctcatcgaa tgaaaactcc agtcaagtac atgaccggga ccactgtcct tccatttaac     2280

ccagcagcct ttggagagat cgttctgtac ttgcgcatgt gccttgcgca cagtgcgggg     2340

gtggtgccca cctctcagag tttggctgat atgcaggatc atgccccagc cattgggcgc     2400

tacatacgga ctttaatgtc aagcgggcag atggcaccct catcatctaa caagagtggg     2460

gagactaacc ctgtccagat ctacattggc ctgcttcagc agctgttagc aggtgttgga     2520

ggtttgccgg ttatgtactg tctattggaa gctgtgtcag tgtatccaga aaagctggct     2580

accaaatttg tagacaaaac agaatggata aagagtctga tgaataacag taaagaagaa     2640

atgcgcgaac tggcagcgtt gttttattct gtagtggtat caacagtgtc ggggaatgag     2700

ttgaaatcaa tgatagaaca gcttataaag actacaaaag acaatcacag cccggagata     2760

cagcatggat ccttgcttgc attgggattc acggtgggaa ggtatttggc taaaaagaaa     2820

atgagaatgt cagagcaaca agacctggag agaaatgctg acaccctccc tgatcaagag     2880

gaactcattc agagtgctac agaaacaata ggctcatttt tggacagtac atcacccctc     2940

ctggcaattg ctgcctgcac agccctgggt gaaattggca gaaatggtcc acttccaatc     3000

cccagtgagg gatctggctt taccaaattg catcttgtag aaagcttact aagtagaata     3060

ccttccagta aagaaacaaa taagatgaaa gaacgagcaa tccaaacact gggatatttt     3120

ccagttgggg atggagattt tcctcaccag aaactcctct tgcaaggtct gatggattct     3180

gtggaggcca agcagataga acttcagttc actattggcg aagccattac cagtgctgca     3240

ataggaacta gttctgtggc tgcccgagat gcctggcaaa tgactgaaga ggaatatact     3300

ccacctgctg tgttacgaga tgacttccga caaaacccca cagatgttgt agtggcagct     3360

ggagagcctg caatcctgga gtgccagcct ccccggggac acccagaacc caccatctac     3420

tggaaaaaag acaaagttcg aattgatgac aaggaagaaa gaataagtat ccgtggtgga     3480

aaactgatga tctccaatac caggaaaagt gatgcaggga tgtatacttg tgttggtacc     3540

aatatggtgg gagaaaggga cagtgaccca gcagagctga ctgtctttga acgacccaca     3600

tttctcagga ggccaattaa ccaggtggta ctggaggaag aagctgtaga atttcgttgt     3660

caagtccaag gagatcctca accaactgtg aggtggaaaa aggatgatgc agacttgcca     3720

agaggaaggt atgacatcaa agacgattac acactaagaa ttaaaaagac catgagtaca     3780

gatgaaggca cctatatgtg tattgctgag aatcgggttg gaaaaatgga agcctctgct     3840

acactcaccg tccgagctcc cccacagttt gtggttcggc caagagatca gattgttgct     3900

caaggtcgaa cagtgacatt tccctgtgaa actaaaggaa acccacagcc agctgttttt     3960

tggcagaaag aaggcagcca gaacctactt ttcccaaacc aaccccagca gcccaacagt     4020

agatgctcag tgtcaccaac tggagacctc acaatcacca acattcaacg ttccgacgcg     4080

ggttactaca tctgccaggc tttaactgtg gcaggaagca ttttagcaaa agctcaactg     4140

gaggttactg atgttttgac agatagacct ccacctataa ttctacaagg cccagccaac     4200

caaacgctgg cagtggatgg tacagcgtta ctgaaatgta aagccactgg tgatcctctt     4260

cctgtaatta gctggttaaa ggagggattt acttttccgg gtagagatcc aagagcaaca     4320

attcaagagc aaggcacact gcagattaag aatttacgga tttctgatac tggcacttat     4380

acttgtgtgg ctacaagttc aagtggagag acttcctgga gtgcagtgct ggatgtgaca     4440

gagtctggag caacaatcag taaaaactat gatttaagtg acctgccagg gccaccatcc     4500

aaaccgcagg tcactgatgt tactaagaac agtgtcacct tgtcctggca gccaggtacc     4560

cctggaaccc ttccagcaag tgcatatatc attgaggctt tcagccaatc agtgagcaac     4620

agctggcaga ccgtggcaaa ccatgtaaag accaccctct atactgtaag aggactgcgg     4680

cccaatacaa tctacttatt catggtcaga gcgatcaacc cccaaggtct cagtgaccca     4740

agtcccatgt cagatcctgt gcgcacacaa gatatcagcc caccagcaca aggagtggac     4800

cacaggcaag tgcagaaaga gctaggagat gtccttgtcc gtcttcataa tccagttgtg     4860

ctgactccca ccacggttca ggtcacatgg acggttgatc gccaacccca gtttatccaa     4920

ggctaccgag tgatgtatcg tcagacttca ggtctgcagg cgacatcttc gtggcagaat     4980

ttagatgcca aagtcccgac tgaacgaagt gctgtcttag tcaacctgaa aaagggggtg     5040

acttatgaaa ttaaagtacg gccatatttt aatgagttcc aaggaatgga tagtgaatct     5100

aaaacggttc gtactactga agaagcccca agtgccccac cacagtctgt cactgtactg     5160

acagttggaa gctacaatag cacaagtatt agtgtttcct gggatcctcc tcctccagat     5220

caccagaatg gaattatcca agaatacaag atctggtgtc taggaaatga aacgcgattc     5280

catatcaaca aaactgtgga tgcagccatt cggtccgtaa taattggtgg attattccca     5340

ggtattcaat accgggtaga ggttgcagct agtaccagtg caggggttgg agtaaagagt     5400

gagccacagc caataataat cgggagacgc aatgaagttg tcattactga aaacaataac     5460

agcataactg agcaaatcac tgatgtggtg aagcaaccag cctttatagc tggtattggt     5520

ggtgcctgct gggtaattct gatgggtttt agcatatggt tgtattggcg aagaaagaag     5580

aggaagggac tcagtaatta tgctgttacg tttcaaagag gagatggagg actaatgagc     5640

aatggaagcc gtccaggtct tctcaatgct ggtgatccca gctatccatg gcttgctgat     5700

tcttggccag ccacgagctt gccagtaaat aatagcaaca gtggcccaaa tgagattgga     5760

aattttggcc gtggagatgt gctgccacca gttccaggcc aaggggataa aacagcaacg     5820

atgctctcag atggagccat ttatagtagc attgacttca ctaccaaaac cagttacaac     5880

agttccagcc aaataacaca ggctacccca tatgccacga cacagatctt gcattccaac     5940

agcatacatg aattggctgt cgatctgcct gatccacaat ggaaaagctc aattcagcaa     6000

aaaacagatc tgatgggatt tggttattct ctacctgatc agaacaaagg taacaatggt     6060

gggaaaggtg gaaaaaagaa gaaaaataaa aactcttcta aaccacagaa aaacaatgga     6120

tccacttggg ccaatgtccc tctacctccc cccccagtcc agccccttcc tggcacggag     6180

ctggaacact atgcagtgga acaacaagaa aatggctatg acagtgatag ctggtgccca     6240

ccattgccag tacaaactta cttacaccaa ggtctggaag atgaactgga agaagatgat     6300

gatagggtcc caacacctcc tgttcgaggc gtggcttctt ctcctgctat ctcctttgga     6360

cagcagtcca ctgcaactct tactccatcc ccacgggaag agatgcaacc catgctgcag     6420

gctcacctgg atgagttgac aagagcctat cagtttgata tagcaaaaca aacatggcac     6480

attcaaagca ataatcaacc tccacagcct ccagttccac cgttaggtta tgtgtctgga     6540

gccttgattt ctgatttgga aacggatgtt gcagatgatg atgccgacga cgaagaggaa     6600

gctttagaaa tccccaggcc cctgagagca ctggaccaga ctcctggatc cagcatggac     6660

aatctagaca gctctgtgac aggaaaagcc tttacctcct ctcaaagacc tcgacctacc     6720

agcccatttt ctactgacag taacaccagt gcagccctga gtcaaagtca gaggcctcgg     6780

cccactaaaa aacacaaggg agggcggatg gaccaacaac cagcattgcc tcatcgaagg     6840

gaaggaatga cagatgagga ggccttggtg ccctatagca agcccagttt cccatctcca     6900

ggtggccaca gctcatcagg aacagcttct tctaagggat ccactggacc taggaaaacc     6960

gaggtgttga gagcaggcca ccagcgcaat gccagcgacc ttcttgacat aggatatatg     7020

ggctccaaca gtcaaggaca gtttacaggt gaattatag                            7059


<210>  3
<211>  3310
<212>  DNA
<213>  Homo sapiens

<400>  3
atgacctcac ggacaaagcg aaggcagaaa gttaaaatca gcatatcgaa aataaatcac       60

tctagttacc gaaaagaaca taggccgttt tgggagcacc agccacctcc acaccagaac      120

tgggctgtcg ggggccgctg cggcgcaggg gctcgtccgg gactgagtca gcgccggggc      180

cgagaagttc ggcgggaggc gcagggcggg gcttcctccc gccgactccg agcccggctc      240

tacttttctg agtccacgtc tcttcctttg gacaggcgtg gcagcccggg cccgctcggc      300

ccagcccctc acggactgcg gcgcgcggct ccccggggcc cggcccgccg aacgcctcgc      360

tctacagccc tcacctcgcg gcgccgagcg cagcgtccgc ggcatggaga ccggctccga      420

ctcaggtcag aggcccgccc ccgggccgcg ggggactggc cctgcgcgcg cggcggcgcg      480

gttaggccgg gccgcccgca caggccgccg cgtgtcgagt ccgcgcgggg agcgcacgcg      540

gggcgggcgg cgacagatca gcttgaacgg gtctttttac gacttggcca tgctgaaaca      600

gatgaacaat tacagaatat tatatctaaa ttccttcctc ctgttttgct caaactctct      660

agcacccaag aaggagtacg taaaaaggta atggaactgc tggtccatct gaataaacgt      720

ataaaaagcc gccccaaaat acaacttcca gtagagacac tgttggttca gtaccaggac      780

cctgctgcag tttcctttgt cacaaatttt actataattt atgttaaaat gggctatcct      840

cgcctaccag tggaaaaaca atgtgaactg gcccctacgc ttcttactgc catggaaggg      900

aagcctcagc cacagcagga tagcttaatg catcttttaa taccaaccct ttttcacatg      960

aaataccctg ttgaatcatc aaaatcagct tctccattta atcttgctga gaaaccaaag     1020

actgtgcagc tgcttttgga cttcatgcta gatgtccttc tgatgcctta tggttacgtg     1080

ttaaatgaat cccagagtcg ccaaaattca tcttcagcac agggttcttc ttcaaacagt     1140

ggcggaggtt ctggaatccc acagcctcct ccgggaatga gcttttatgc agccaaacga     1200

gttattggtg ataacccatg gacacctgaa caattggaac agtgcaaatt gggaatcgtg     1260

aaattcatag aagctgaaca ggtgcctgaa cttgaagctg ttctccactt ggtgattgcc     1320

tctagtgata cacgccacag tgtggcaacg gcagcagacc tggaattgaa aagcaaacag     1380

agcttaattg actggaataa tcctgccatc attaataaga tgtacaaggt gtaccttgga     1440

gatataccac tgaagacaaa agagggtgca gttctgaagc cagagttgaa aagggaccct     1500

gtcagtacaa gagtcaagtt aaagattgtc ccccatctcc tccgctctag acaagctgct     1560

gaaacgttcc cagccaacat tcaggtggtg tatgatggac tttttggtac aaatacaaat     1620

tcaaagttaa gaacattatc cctgcaattt gtgcatcata tttgtataac ctgtccagaa     1680

atcaagatta agccattagg tccaatgctt ttgaatggcc tcaccaagct aatcaatgaa     1740

tacaaagagg accctaaact actgtcaatg gcatattcag ctgttggaaa actctccagt     1800

cggatgccac atttattcac taaggatata gcgcttgtgc agcagctttt tgaagccctt     1860

tgcaaggaag agcctgagac tcgacttgct attcaagaag ctttatctat gatggttgga     1920

gcgtatagta ctttggaagg ggcacagcga actctcatgg aggcacttgt ggcttcgtac     1980

ttaataaagc ctgaagttca agttcgacaa gtggctgtga aatttgccag tacggtgttt     2040

ccctcagatc atatcccttc cagatatttg ctgctactgg ctgcaggaga tccacgtgaa     2100

gaagttcatg gagaagcaca acgcgtatta aggtgtcttc caggtagaaa cagaaaagaa     2160

agtacttctg agcagatgcc ttccttccca gaaatggttt attacatcca agaaaaggct     2220

tctcatcgaa tgaaaactcc agtcaagtac atgaccggga ccactgtcct tccatttaac     2280

ccagcagcct ttggagagat cgttctgtac ttgcgcatgt gccttgcgca cagtgcgggg     2340

gtggtgccca cctctcagag tttggctgat atgcaggatc atgccccagc cattgggcgc     2400

tacatacgga ctttaatgtc aagcgggcag atggcaccct catcatctaa caagagtggg     2460

gagactaacc ctgtccagat ctacattggc ctgcttcagc agctgttagc aggtgttgga     2520

ggtttgccgg ttatgtactg tctattggaa gctgtgtcag tgtatccaga aaagctggct     2580

accaaatttg tagacaaaac agaatggata aagagtctga tgaataacag taaagaagaa     2640

atgcgcgaac tggcagcgtt gttttattct gtagtggtat caacagtgtc ggggaatgag     2700

ttgaaatcaa tgatagaaca gcttataaag actacaaaag acaatcacag cccggagata     2760

cagcatggat ccttgcttgc attgggattc acggtgggaa ggtatttggc taaaaagaaa     2820

atgagaatgt cagagcaaca agacctggag agaaatgctg acaccctccc tgatcaagag     2880

gaactcattc agagtgctac agaaacaata ggctcatttt tggacagtac atcacccctc     2940

ctggcaattg ctgcctgcac agccctgggt gaaattggca gaaatggtcc acttccaatc     3000

cccagtgagg gatctggctt taccaaattg catcttgtag aaagcttact aagtagaata     3060

ccttccagta aagaaacaaa taagatgaaa gaacgagcaa tccaaacact gggatatttt     3120

ccagttgggg atggagattt tcctcaccag aaactcctct tgcaaggtct gatggattct     3180

gtggaggcca agcagataga acttcagttc actattggcg aagccattac cagtgctgca     3240

ataggaacta gttctgtggc tgcccgagat gcctggcaaa tgactgaaga ggaatatact     3300

ccacctgctg                                                            3310


<210>  4
<211>  3749
<212>  DNA
<213>  Homo sapiens

<400>  4
tgttacgaga tgacttccga caaaacccca cagatgttgt agtggcagct ggagagcctg       60

caatcctgga gtgccagcct ccccggggac acccagaacc caccatctac tggaaaaaag      120

acaaagttcg aattgatgac aaggaagaaa gaataagtat ccgtggtgga aaactgatga      180

tctccaatac caggaaaagt gatgcaggga tgtatacttg tgttggtacc aatatggtgg      240

gagaaaggga cagtgaccca gcagagctga ctgtctttga acgacccaca tttctcagga      300

ggccaattaa ccaggtggta ctggaggaag aagctgtaga atttcgttgt caagtccaag      360

gagatcctca accaactgtg aggtggaaaa aggatgatgc agacttgcca agaggaaggt      420

atgacatcaa agacgattac acactaagaa ttaaaaagac catgagtaca gatgaaggca      480

cctatatgtg tattgctgag aatcgggttg gaaaaatgga agcctctgct acactcaccg      540

tccgagctcc cccacagttt gtggttcggc caagagatca gattgttgct caaggtcgaa      600

cagtgacatt tccctgtgaa actaaaggaa acccacagcc agctgttttt tggcagaaag      660

aaggcagcca gaacctactt ttcccaaacc aaccccagca gcccaacagt agatgctcag      720

tgtcaccaac tggagacctc acaatcacca acattcaacg ttccgacgcg ggttactaca      780

tctgccaggc tttaactgtg gcaggaagca ttttagcaaa agctcaactg gaggttactg      840

atgttttgac agatagacct ccacctataa ttctacaagg cccagccaac caaacgctgg      900

cagtggatgg tacagcgtta ctgaaatgta aagccactgg tgatcctctt cctgtaatta      960

gctggttaaa ggagggattt acttttccgg gtagagatcc aagagcaaca attcaagagc     1020

aaggcacact gcagattaag aatttacgga tttctgatac tggcacttat acttgtgtgg     1080

ctacaagttc aagtggagag acttcctgga gtgcagtgct ggatgtgaca gagtctggag     1140

caacaatcag taaaaactat gatttaagtg acctgccagg gccaccatcc aaaccgcagg     1200

tcactgatgt tactaagaac agtgtcacct tgtcctggca gccaggtacc cctggaaccc     1260

ttccagcaag tgcatatatc attgaggctt tcagccaatc agtgagcaac agctggcaga     1320

ccgtggcaaa ccatgtaaag accaccctct atactgtaag aggactgcgg cccaatacaa     1380

tctacttatt catggtcaga gcgatcaacc cccaaggtct cagtgaccca agtcccatgt     1440

cagatcctgt gcgcacacaa gatatcagcc caccagcaca aggagtggac cacaggcaag     1500

tgcagaaaga gctaggagat gtccttgtcc gtcttcataa tccagttgtg ctgactccca     1560

ccacggttca ggtcacatgg acggttgatc gccaacccca gtttatccaa ggctaccgag     1620

tgatgtatcg tcagacttca ggtctgcagg cgacatcttc gtggcagaat ttagatgcca     1680

aagtcccgac tgaacgaagt gctgtcttag tcaacctgaa aaagggggtg acttatgaaa     1740

ttaaagtacg gccatatttt aatgagttcc aaggaatgga tagtgaatct aaaacggttc     1800

gtactactga agaagcccca agtgccccac cacagtctgt cactgtactg acagttggaa     1860

gctacaatag cacaagtatt agtgtttcct gggatcctcc tcctccagat caccagaatg     1920

gaattatcca agaatacaag atctggtgtc taggaaatga aacgcgattc catatcaaca     1980

aaactgtgga tgcagccatt cggtccgtaa taattggtgg attattccca ggtattcaat     2040

accgggtaga ggttgcagct agtaccagtg caggggttgg agtaaagagt gagccacagc     2100

caataataat cgggagacgc aatgaagttg tcattactga aaacaataac agcataactg     2160

agcaaatcac tgatgtggtg aagcaaccag cctttatagc tggtattggt ggtgcctgct     2220

gggtaattct gatgggtttt agcatatggt tgtattggcg aagaaagaag aggaagggac     2280

tcagtaatta tgctgttacg tttcaaagag gagatggagg actaatgagc aatggaagcc     2340

gtccaggtct tctcaatgct ggtgatccca gctatccatg gcttgctgat tcttggccag     2400

ccacgagctt gccagtaaat aatagcaaca gtggcccaaa tgagattgga aattttggcc     2460

gtggagatgt gctgccacca gttccaggcc aaggggataa aacagcaacg atgctctcag     2520

atggagccat ttatagtagc attgacttca ctaccaaaac cagttacaac agttccagcc     2580

aaataacaca ggctacccca tatgccacga cacagatctt gcattccaac agcatacatg     2640

aattggctgt cgatctgcct gatccacaat ggaaaagctc aattcagcaa aaaacagatc     2700

tgatgggatt tggttattct ctacctgatc agaacaaagg taacaatggt gggaaaggtg     2760

gaaaaaagaa gaaaaataaa aactcttcta aaccacagaa aaacaatgga tccacttggg     2820

ccaatgtccc tctacctccc cccccagtcc agccccttcc tggcacggag ctggaacact     2880

atgcagtgga acaacaagaa aatggctatg acagtgatag ctggtgccca ccattgccag     2940

tacaaactta cttacaccaa ggtctggaag atgaactgga agaagatgat gatagggtcc     3000

caacacctcc tgttcgaggc gtggcttctt ctcctgctat ctcctttgga cagcagtcca     3060

ctgcaactct tactccatcc ccacgggaag agatgcaacc catgctgcag gctcacctgg     3120

atgagttgac aagagcctat cagtttgata tagcaaaaca aacatggcac attcaaagca     3180

ataatcaacc tccacagcct ccagttccac cgttaggtta tgtgtctgga gccttgattt     3240

ctgatttgga aacggatgtt gcagatgatg atgccgacga cgaagaggaa gctttagaaa     3300

tccccaggcc cctgagagca ctggaccaga ctcctggatc cagcatggac aatctagaca     3360

gctctgtgac aggaaaagcc tttacctcct ctcaaagacc tcgacctacc agcccatttt     3420

ctactgacag taacaccagt gcagccctga gtcaaagtca gaggcctcgg cccactaaaa     3480

aacacaaggg agggcggatg gaccaacaac cagcattgcc tcatcgaagg gaaggaatga     3540

cagatgagga ggccttggtg ccctatagca agcccagttt cccatctcca ggtggccaca     3600

gctcatcagg aacagcttct tctaagggat ccactggacc taggaaaacc gaggtgttga     3660

gagcaggcca ccagcgcaat gccagcgacc ttcttgacat aggatatatg ggctccaaca     3720

gtcaaggaca gtttacaggt gaattatag                                       3749


<210>  5
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PCR primer

<400>  5
gcagacttgc caagaggaag                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PCR primer

<400>  6
ttttccaacc cgattctcag                                                   20


<210>  7
<211>  20
<212>  DNA
<213>  Artificial sequene

<220>
<223>  PCR primer

<400>  7
ttggattgct cgttctttca                                                   20


<210>  8
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PCR primer

<400>  8
tgagggatct ggctttacca                                                   20


