                         SEQUENCE LISTING

<110>  Helmholtz
       Krappmann et al., Daniel
 
<120>  Means and methods for detecting activated MALT1

<130>  759-13 PCT

<150>  EP14151913.2
<151>  2014-01-21

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  5046
<212>  DNA
<213>  human

<400>  1
cgaggctccg tgccccgccc cccgggtgcc ccgccccttt gcgcggctgg cgcggccagc       60

aggccaggct cccctcggca aacctgtcta attggggcgg ggagcggagc ttcctcctct      120

gagggccgtg ccgcgctgcc agatttgttc ttccgcccct gcctccgcgg ctcggaggcg      180

agcggaaggt gccccggggc cgaggcccgt gacggggcgg gcgggagccc cggcagtccg      240

gggtcgccgg cgagggccat gtcgctgttg ggggacccgc tacaggccct gccgccctcg      300

gccgccccca cggggccgct gctcgcccct ccggccggcg cgaccctcaa ccgcctgcgg      360

gagccgctgc tgcggaggct cagcgagctc ctggatcagg cgcccgaggg ccggggctgg      420

aggagactgg cggagctggc ggggagtcgc gggcgcctcc gcctcagttg cctagacctg      480

gagcagtgtt ctcttaaggt actggagcct gaaggaagcc ccagcctgtg tctgctgaag      540

ttaatgggtg aaaaaggttg cacagtcaca gaattgagtg atttcctgca ggctatggaa      600

cacactgaag ttcttcagct tctcagcccc ccaggaataa agattactgt aaacccagag      660

tcaaaggcag tcttggctgg acagtttgtg aaactgtgtt gccgggcaac tggacatcct      720

tttgttcaat atcagtggtt caaaatgaat aaagagattc caaatggaaa tacatcagag      780

cttattttta atgcagtgca tgtaaaagat gcaggctttt atgtctgtcg agttaataac      840

aatttcacct ttgaattcag ccagtggtca cagctggatg tttgcgacat cccagagagc      900

ttccagagaa gtgttgatgg cgtctctgaa tccaagttgc aaatctgtgt tgaaccaact      960

tcccaaaagc tgatgccagg cagcacattg gttttacagt gtgttgctgt tggaagccct     1020

attcctcact accagtggtt caaaaatgaa ttaccattaa cacatgagac caaaaagcta     1080

tacatggtgc cttatgtgga tttggaacac caaggaacct actggtgtca tgtatataat     1140

gatcgagaca gtcaagatag caagaaggta gaaatcatca taggaagaac agatgaggca     1200

gtggagtgca ctgaagatga attaaataat cttggtcatc ctgataataa agagcaaaca     1260

actgaccagc ctttggcgaa ggacaaggtt gcccttttga taggaaatat gaattaccgg     1320

gagcacccca agctcaaagc tcctttggtg gatgtgtacg aattgactaa cttactgaga     1380

cagctggact tcaaagtggt ttcactgttg gatcttactg aatatgagat gcgtaatgct     1440

gtggatgagt ttttactcct tttagacaag ggagtatatg ggttattata ttatgcagga     1500

catggttatg aaaattttgg gaacagcttc atggtccccg ttgatgctcc aaatccatat     1560

aggtctgaaa attgtctgtg tgtacaaaat atactgaaat tgatgcaaga aaaagaaact     1620

ggacttaatg tgttcttatt ggatatgtgt aggaaaagaa atgactacga tgataccatt     1680

ccaatcttgg atgcactaaa agtcaccgcc aatattgtgt ttggatatgc cacgtgtcaa     1740

ggagcagaag cttttgaaat ccagcattct ggattggcaa atggaatctt tatgaaattt     1800

ttaaaagaca gattattaga agataagaaa atcactgtgt tactggatga agttgcagaa     1860

gatatgggta agtgtcacct taccaaaggc aaacaggctc tagagattcg aagtagttta     1920

tctgagaaga gagcacttac tgatccaata cagggaacag aatattctgc tgaatctctt     1980

gtgcggaatc tacagtgggc caaggctcat gaacttccag aaagtatgtg tcttaagttt     2040

gactgtggtg ttcagattca attaggattt gcagctgagt tttccaatgt catgatcatc     2100

tatacaagta tagtttacaa accaccggag ataataatgt gtgatgccta cgttactgat     2160

tttccacttg atctagatat tgatccaaaa gatgcaaata aaggcacacc tgaagaaact     2220

ggcagctact tggtatcaaa ggatcttccc aagcattgcc tctataccag actcagttca     2280

ctgcaaaaat taaaggaaca tctagtcttc acagtatgtt tatcatatca gtactcagga     2340

ttggaagata ctgtagagga caagcaggaa gtgaatgttg ggaaacctct cattgctaaa     2400

ttagacatgc atcgaggttt gggaaggaag acttgctttc aaacttgtct tatgtctaat     2460

ggtccttacc agagttctgc agccacctca ggaggagcag ggcattatca ctcattgcaa     2520

gacccattcc atggtgttta ccattcacat cctggtaatc caagtaatgt tacaccagca     2580

gatagctgtc attgcagccg gactccagat gcatttattt caagtttcgc tcaccatgct     2640

tcatgtcatt ttagtagaag taatgtgcca gtagagacaa ctgatgaaat accatttagt     2700

ttctctgaca ggctcagaat ttctgaaaaa tgacctcctt gtttttgaaa gttagcataa     2760

ttttagatgc ctgtgaaata gtactgcact tacataaagt gagacattgt gaaaaggcaa     2820

atttgtatat gtagagaaag aatagtagta actgtttcat agcaaacttc aggactttga     2880

gatgttgaaa ttacattatt taattacaga cttcctcttt ctaagatttt gtgaattggt     2940

tgaatagttc tatacaaatg aagtatggag gtgtgtatgt ttatatgtat ataacaaaat     3000

attttcattg tgaccactct gaagtaagag caatgggaat ggcattattg tagaataagt     3060

cattgtattt ttaacaccag aaagaacctt gccgatcacc aggcataacc taattttatc     3120

catggaagaa acacagaaag gcatctaagt tagagctggc accagaactg agacctccag     3180

aaatctattc cagtattttt tccactacac aactgccttc ctgacaggtt ctgagataag     3240

tgttatgttt gtagatagag tgaaatatat ttatatatat ataaatatat acagatacat     3300

atctgtgtat tatctcaagg aatgtacaaa ctttagtttt tgattataag gacttcactg     3360

caagttttag ttaagaggtt tgtatataaa tctgttatag aacaggctga aatttcttgt     3420

tcataagatt atgaaaccac atgagaagtg ataaaatgtt tgttaaagct agatagaggt     3480

taagaatcaa gatataatgg ataattttca tagctgccta tcagaatttc ccaaatattt     3540

agcatcttcc ttgataatat gtattttctt cttgaatttc actggcctaa tgagataata     3600

ctcttatctt tggctctacc taaaagttgg ttaaaaatgc aattggcatt aacaaggaaa     3660

aatactgaat tagtaatttt aaaagtctca caaagaaaat cccaggccta gatggctgca     3720

ttgttgaatt ctgccaaaca ttaaaattag cactaatttt ttgcacactg tttctaaaag     3780

taggagagga aagaacactt cccaacttac tctaggtcag tattaccctg atactagact     3840

agacatcaca agaaaactat aagccaatat tccttattaa tacaaacaca aaaatcatta     3900

acaaaaatat tagcaaactg aatccagcaa cctataaaaa ggattctata tcatgaccaa     3960

gtggaattta tcccaggaat tcaaggttgg ttcaacatct aaaaatcaaa taagctaata     4020

tacagtcagt tctcattatt cacagtaatt atgttctaca gaatattctc ccataaacac     4080

tgaattaaat atggaacaac tgcttttagg agaaagtgta tttgtgtata tgtgtgtata     4140

catatgttta tctcacacac attatgagct tgaattctta attcatccta gcaaattcta     4200

ccttatttta cagaagtgaa agtgaggtat cagaagtgtt aagtgacatg cctgaggcac     4260

ccccctaaca ggtgtcagag ctgaaattca aaccccatcc agctggcccc ggagccagag     4320

cttcttgtac tacacagaat tgcccctgcc atttccaccc tccagtcatt tctctatgag     4380

actgaagcag gaaggcagag catcatcttg ttcagcctca gctgggaaca tgtgtactgg     4440

gtgactcaaa tttttcaccc atttacacat atccacaaat gactgcaaaa gtgccacgga     4500

tatcaatttg agggttataa attttagcaa gttggtaaat tcacaaatac ataaccttga     4560

ataatgagga tcaactgtac catatttaat aaagcacaaa acccacacag attgtcttat     4620

tacagcattt gataaaatcc aaaactcttt cataaaaaca ctcaacaaac ttaggaataa     4680

aaggaatctt cctagatatg ataaatataa catctatgaa aagcccacac ctaacattat     4740

acttcatggt gatagactga aggctgaatg ttttcccctt aagattggga agaaggacaa     4800

ggatgttcac tcggcactac ttctattcag cattgtactt gaagttctag ccacagcagt     4860

taggttagga attcaaggtt tgttcaacat ctaaaaatca aataagctaa taaagaaaag     4920

aggtttatac tgcaaaagaa gtgaaactat atgtattcac agttgataca tagttgtata     4980

tagaaaatgc taaagaatcc ataaaaagta ataaatgagt tcaacaggtt aaaaaaaaaa     5040

aaaaaa                                                                5046


<210>  2
<211>  824
<212>  PRT
<213>  human

<400>  2

Met Ser Leu Leu Gly Asp Pro Leu Gln Ala Leu Pro Pro Ser Ala Ala 
1               5                   10                  15      


Pro Thr Gly Pro Leu Leu Ala Pro Pro Ala Gly Ala Thr Leu Asn Arg 
            20                  25                  30          


Leu Arg Glu Pro Leu Leu Arg Arg Leu Ser Glu Leu Leu Asp Gln Ala 
        35                  40                  45              


Pro Glu Gly Arg Gly Trp Arg Arg Leu Ala Glu Leu Ala Gly Ser Arg 
    50                  55                  60                  


Gly Arg Leu Arg Leu Ser Cys Leu Asp Leu Glu Gln Cys Ser Leu Lys 
65                  70                  75                  80  


Val Leu Glu Pro Glu Gly Ser Pro Ser Leu Cys Leu Leu Lys Leu Met 
                85                  90                  95      


Gly Glu Lys Gly Cys Thr Val Thr Glu Leu Ser Asp Phe Leu Gln Ala 
            100                 105                 110         


Met Glu His Thr Glu Val Leu Gln Leu Leu Ser Pro Pro Gly Ile Lys 
        115                 120                 125             


Ile Thr Val Asn Pro Glu Ser Lys Ala Val Leu Ala Gly Gln Phe Val 
    130                 135                 140                 


Lys Leu Cys Cys Arg Ala Thr Gly His Pro Phe Val Gln Tyr Gln Trp 
145                 150                 155                 160 


Phe Lys Met Asn Lys Glu Ile Pro Asn Gly Asn Thr Ser Glu Leu Ile 
                165                 170                 175     


Phe Asn Ala Val His Val Lys Asp Ala Gly Phe Tyr Val Cys Arg Val 
            180                 185                 190         


Asn Asn Asn Phe Thr Phe Glu Phe Ser Gln Trp Ser Gln Leu Asp Val 
        195                 200                 205             


Cys Asp Ile Pro Glu Ser Phe Gln Arg Ser Val Asp Gly Val Ser Glu 
    210                 215                 220                 


Ser Lys Leu Gln Ile Cys Val Glu Pro Thr Ser Gln Lys Leu Met Pro 
225                 230                 235                 240 


Gly Ser Thr Leu Val Leu Gln Cys Val Ala Val Gly Ser Pro Ile Pro 
                245                 250                 255     


His Tyr Gln Trp Phe Lys Asn Glu Leu Pro Leu Thr His Glu Thr Lys 
            260                 265                 270         


Lys Leu Tyr Met Val Pro Tyr Val Asp Leu Glu His Gln Gly Thr Tyr 
        275                 280                 285             


Trp Cys His Val Tyr Asn Asp Arg Asp Ser Gln Asp Ser Lys Lys Val 
    290                 295                 300                 


Glu Ile Ile Ile Gly Arg Thr Asp Glu Ala Val Glu Cys Thr Glu Asp 
305                 310                 315                 320 


Glu Leu Asn Asn Leu Gly His Pro Asp Asn Lys Glu Gln Thr Thr Asp 
                325                 330                 335     


Gln Pro Leu Ala Lys Asp Lys Val Ala Leu Leu Ile Gly Asn Met Asn 
            340                 345                 350         


Tyr Arg Glu His Pro Lys Leu Lys Ala Pro Leu Val Asp Val Tyr Glu 
        355                 360                 365             


Leu Thr Asn Leu Leu Arg Gln Leu Asp Phe Lys Val Val Ser Leu Leu 
    370                 375                 380                 


Asp Leu Thr Glu Tyr Glu Met Arg Asn Ala Val Asp Glu Phe Leu Leu 
385                 390                 395                 400 


Leu Leu Asp Lys Gly Val Tyr Gly Leu Leu Tyr Tyr Ala Gly His Gly 
                405                 410                 415     


Tyr Glu Asn Phe Gly Asn Ser Phe Met Val Pro Val Asp Ala Pro Asn 
            420                 425                 430         


Pro Tyr Arg Ser Glu Asn Cys Leu Cys Val Gln Asn Ile Leu Lys Leu 
        435                 440                 445             


Met Gln Glu Lys Glu Thr Gly Leu Asn Val Phe Leu Leu Asp Met Cys 
    450                 455                 460                 


Arg Lys Arg Asn Asp Tyr Asp Asp Thr Ile Pro Ile Leu Asp Ala Leu 
465                 470                 475                 480 


Lys Val Thr Ala Asn Ile Val Phe Gly Tyr Ala Thr Cys Gln Gly Ala 
                485                 490                 495     


Glu Ala Phe Glu Ile Gln His Ser Gly Leu Ala Asn Gly Ile Phe Met 
            500                 505                 510         


Lys Phe Leu Lys Asp Arg Leu Leu Glu Asp Lys Lys Ile Thr Val Leu 
        515                 520                 525             


Leu Asp Glu Val Ala Glu Asp Met Gly Lys Cys His Leu Thr Lys Gly 
    530                 535                 540                 


Lys Gln Ala Leu Glu Ile Arg Ser Ser Leu Ser Glu Lys Arg Ala Leu 
545                 550                 555                 560 


Thr Asp Pro Ile Gln Gly Thr Glu Tyr Ser Ala Glu Ser Leu Val Arg 
                565                 570                 575     


Asn Leu Gln Trp Ala Lys Ala His Glu Leu Pro Glu Ser Met Cys Leu 
            580                 585                 590         


Lys Phe Asp Cys Gly Val Gln Ile Gln Leu Gly Phe Ala Ala Glu Phe 
        595                 600                 605             


Ser Asn Val Met Ile Ile Tyr Thr Ser Ile Val Tyr Lys Pro Pro Glu 
    610                 615                 620                 


Ile Ile Met Cys Asp Ala Tyr Val Thr Asp Phe Pro Leu Asp Leu Asp 
625                 630                 635                 640 


Ile Asp Pro Lys Asp Ala Asn Lys Gly Thr Pro Glu Glu Thr Gly Ser 
                645                 650                 655     


Tyr Leu Val Ser Lys Asp Leu Pro Lys His Cys Leu Tyr Thr Arg Leu 
            660                 665                 670         


Ser Ser Leu Gln Lys Leu Lys Glu His Leu Val Phe Thr Val Cys Leu 
        675                 680                 685             


Ser Tyr Gln Tyr Ser Gly Leu Glu Asp Thr Val Glu Asp Lys Gln Glu 
    690                 695                 700                 


Val Asn Val Gly Lys Pro Leu Ile Ala Lys Leu Asp Met His Arg Gly 
705                 710                 715                 720 


Leu Gly Arg Lys Thr Cys Phe Gln Thr Cys Leu Met Ser Asn Gly Pro 
                725                 730                 735     


Tyr Gln Ser Ser Ala Ala Thr Ser Gly Gly Ala Gly His Tyr His Ser 
            740                 745                 750         


Leu Gln Asp Pro Phe His Gly Val Tyr His Ser His Pro Gly Asn Pro 
        755                 760                 765             


Ser Asn Val Thr Pro Ala Asp Ser Cys His Cys Ser Arg Thr Pro Asp 
    770                 775                 780                 


Ala Phe Ile Ser Ser Phe Ala His His Ala Ser Cys His Phe Ser Arg 
785                 790                 795                 800 


Ser Asn Val Pro Val Glu Thr Thr Asp Glu Ile Pro Phe Ser Phe Ser 
                805                 810                 815     


Asp Arg Leu Arg Ile Ser Glu Lys 
            820                 


<210>  3
<211>  5013
<212>  DNA
<213>  human

<400>  3
cgaggctccg tgccccgccc cccgggtgcc ccgccccttt gcgcggctgg cgcggccagc       60

aggccaggct cccctcggca aacctgtcta attggggcgg ggagcggagc ttcctcctct      120

gagggccgtg ccgcgctgcc agatttgttc ttccgcccct gcctccgcgg ctcggaggcg      180

agcggaaggt gccccggggc cgaggcccgt gacggggcgg gcgggagccc cggcagtccg      240

gggtcgccgg cgagggccat gtcgctgttg ggggacccgc tacaggccct gccgccctcg      300

gccgccccca cggggccgct gctcgcccct ccggccggcg cgaccctcaa ccgcctgcgg      360

gagccgctgc tgcggaggct cagcgagctc ctggatcagg cgcccgaggg ccggggctgg      420

aggagactgg cggagctggc ggggagtcgc gggcgcctcc gcctcagttg cctagacctg      480

gagcagtgtt ctcttaaggt actggagcct gaaggaagcc ccagcctgtg tctgctgaag      540

ttaatgggtg aaaaaggttg cacagtcaca gaattgagtg atttcctgca ggctatggaa      600

cacactgaag ttcttcagct tctcagcccc ccaggaataa agattactgt aaacccagag      660

tcaaaggcag tcttggctgg acagtttgtg aaactgtgtt gccgggcaac tggacatcct      720

tttgttcaat atcagtggtt caaaatgaat aaagagattc caaatggaaa tacatcagag      780

cttattttta atgcagtgca tgtaaaagat gcaggctttt atgtctgtcg agttaataac      840

aatttcacct ttgaattcag ccagtggtca cagctggatg tttgcgacat cccagagagc      900

ttccagagaa gtgttgatgg cgtctctgaa tccaagttgc aaatctgtgt tgaaccaact      960

tcccaaaagc tgatgccagg cagcacattg gttttacagt gtgttgctgt tggaagccct     1020

attcctcact accagtggtt caaaaatgaa ttaccattaa cacatgagac caaaaagcta     1080

tacatggtgc cttatgtgga tttggaacac caaggaacct actggtgtca tgtatataat     1140

gatcgagaca gtcaagatag caagaaggta gaaatcatca tagatgaatt aaataatctt     1200

ggtcatcctg ataataaaga gcaaacaact gaccagcctt tggcgaagga caaggttgcc     1260

cttttgatag gaaatatgaa ttaccgggag caccccaagc tcaaagctcc tttggtggat     1320

gtgtacgaat tgactaactt actgagacag ctggacttca aagtggtttc actgttggat     1380

cttactgaat atgagatgcg taatgctgtg gatgagtttt tactcctttt agacaaggga     1440

gtatatgggt tattatatta tgcaggacat ggttatgaaa attttgggaa cagcttcatg     1500

gtccccgttg atgctccaaa tccatatagg tctgaaaatt gtctgtgtgt acaaaatata     1560

ctgaaattga tgcaagaaaa agaaactgga cttaatgtgt tcttattgga tatgtgtagg     1620

aaaagaaatg actacgatga taccattcca atcttggatg cactaaaagt caccgccaat     1680

attgtgtttg gatatgccac gtgtcaagga gcagaagctt ttgaaatcca gcattctgga     1740

ttggcaaatg gaatctttat gaaattttta aaagacagat tattagaaga taagaaaatc     1800

actgtgttac tggatgaagt tgcagaagat atgggtaagt gtcaccttac caaaggcaaa     1860

caggctctag agattcgaag tagtttatct gagaagagag cacttactga tccaatacag     1920

ggaacagaat attctgctga atctcttgtg cggaatctac agtgggccaa ggctcatgaa     1980

cttccagaaa gtatgtgtct taagtttgac tgtggtgttc agattcaatt aggatttgca     2040

gctgagtttt ccaatgtcat gatcatctat acaagtatag tttacaaacc accggagata     2100

ataatgtgtg atgcctacgt tactgatttt ccacttgatc tagatattga tccaaaagat     2160

gcaaataaag gcacacctga agaaactggc agctacttgg tatcaaagga tcttcccaag     2220

cattgcctct ataccagact cagttcactg caaaaattaa aggaacatct agtcttcaca     2280

gtatgtttat catatcagta ctcaggattg gaagatactg tagaggacaa gcaggaagtg     2340

aatgttggga aacctctcat tgctaaatta gacatgcatc gaggtttggg aaggaagact     2400

tgctttcaaa cttgtcttat gtctaatggt ccttaccaga gttctgcagc cacctcagga     2460

ggagcagggc attatcactc attgcaagac ccattccatg gtgtttacca ttcacatcct     2520

ggtaatccaa gtaatgttac accagcagat agctgtcatt gcagccggac tccagatgca     2580

tttatttcaa gtttcgctca ccatgcttca tgtcatttta gtagaagtaa tgtgccagta     2640

gagacaactg atgaaatacc atttagtttc tctgacaggc tcagaatttc tgaaaaatga     2700

cctccttgtt tttgaaagtt agcataattt tagatgcctg tgaaatagta ctgcacttac     2760

ataaagtgag acattgtgaa aaggcaaatt tgtatatgta gagaaagaat agtagtaact     2820

gtttcatagc aaacttcagg actttgagat gttgaaatta cattatttaa ttacagactt     2880

cctctttcta agattttgtg aattggttga atagttctat acaaatgaag tatggaggtg     2940

tgtatgttta tatgtatata acaaaatatt ttcattgtga ccactctgaa gtaagagcaa     3000

tgggaatggc attattgtag aataagtcat tgtattttta acaccagaaa gaaccttgcc     3060

gatcaccagg cataacctaa ttttatccat ggaagaaaca cagaaaggca tctaagttag     3120

agctggcacc agaactgaga cctccagaaa tctattccag tattttttcc actacacaac     3180

tgccttcctg acaggttctg agataagtgt tatgtttgta gatagagtga aatatattta     3240

tatatatata aatatataca gatacatatc tgtgtattat ctcaaggaat gtacaaactt     3300

tagtttttga ttataaggac ttcactgcaa gttttagtta agaggtttgt atataaatct     3360

gttatagaac aggctgaaat ttcttgttca taagattatg aaaccacatg agaagtgata     3420

aaatgtttgt taaagctaga tagaggttaa gaatcaagat ataatggata attttcatag     3480

ctgcctatca gaatttccca aatatttagc atcttccttg ataatatgta ttttcttctt     3540

gaatttcact ggcctaatga gataatactc ttatctttgg ctctacctaa aagttggtta     3600

aaaatgcaat tggcattaac aaggaaaaat actgaattag taattttaaa agtctcacaa     3660

agaaaatccc aggcctagat ggctgcattg ttgaattctg ccaaacatta aaattagcac     3720

taattttttg cacactgttt ctaaaagtag gagaggaaag aacacttccc aacttactct     3780

aggtcagtat taccctgata ctagactaga catcacaaga aaactataag ccaatattcc     3840

ttattaatac aaacacaaaa atcattaaca aaaatattag caaactgaat ccagcaacct     3900

ataaaaagga ttctatatca tgaccaagtg gaatttatcc caggaattca aggttggttc     3960

aacatctaaa aatcaaataa gctaatatac agtcagttct cattattcac agtaattatg     4020

ttctacagaa tattctccca taaacactga attaaatatg gaacaactgc ttttaggaga     4080

aagtgtattt gtgtatatgt gtgtatacat atgtttatct cacacacatt atgagcttga     4140

attcttaatt catcctagca aattctacct tattttacag aagtgaaagt gaggtatcag     4200

aagtgttaag tgacatgcct gaggcacccc cctaacaggt gtcagagctg aaattcaaac     4260

cccatccagc tggccccgga gccagagctt cttgtactac acagaattgc ccctgccatt     4320

tccaccctcc agtcatttct ctatgagact gaagcaggaa ggcagagcat catcttgttc     4380

agcctcagct gggaacatgt gtactgggtg actcaaattt ttcacccatt tacacatatc     4440

cacaaatgac tgcaaaagtg ccacggatat caatttgagg gttataaatt ttagcaagtt     4500

ggtaaattca caaatacata accttgaata atgaggatca actgtaccat atttaataaa     4560

gcacaaaacc cacacagatt gtcttattac agcatttgat aaaatccaaa actctttcat     4620

aaaaacactc aacaaactta ggaataaaag gaatcttcct agatatgata aatataacat     4680

ctatgaaaag cccacaccta acattatact tcatggtgat agactgaagg ctgaatgttt     4740

tccccttaag attgggaaga aggacaagga tgttcactcg gcactacttc tattcagcat     4800

tgtacttgaa gttctagcca cagcagttag gttaggaatt caaggtttgt tcaacatcta     4860

aaaatcaaat aagctaataa agaaaagagg tttatactgc aaaagaagtg aaactatatg     4920

tattcacagt tgatacatag ttgtatatag aaaatgctaa agaatccata aaaagtaata     4980

aatgagttca acaggttaaa aaaaaaaaaa aaa                                  5013


<210>  4
<211>  813
<212>  PRT
<213>  human

<400>  4

Met Ser Leu Leu Gly Asp Pro Leu Gln Ala Leu Pro Pro Ser Ala Ala 
1               5                   10                  15      


Pro Thr Gly Pro Leu Leu Ala Pro Pro Ala Gly Ala Thr Leu Asn Arg 
            20                  25                  30          


Leu Arg Glu Pro Leu Leu Arg Arg Leu Ser Glu Leu Leu Asp Gln Ala 
        35                  40                  45              


Pro Glu Gly Arg Gly Trp Arg Arg Leu Ala Glu Leu Ala Gly Ser Arg 
    50                  55                  60                  


Gly Arg Leu Arg Leu Ser Cys Leu Asp Leu Glu Gln Cys Ser Leu Lys 
65                  70                  75                  80  


Val Leu Glu Pro Glu Gly Ser Pro Ser Leu Cys Leu Leu Lys Leu Met 
                85                  90                  95      


Gly Glu Lys Gly Cys Thr Val Thr Glu Leu Ser Asp Phe Leu Gln Ala 
            100                 105                 110         


Met Glu His Thr Glu Val Leu Gln Leu Leu Ser Pro Pro Gly Ile Lys 
        115                 120                 125             


Ile Thr Val Asn Pro Glu Ser Lys Ala Val Leu Ala Gly Gln Phe Val 
    130                 135                 140                 


Lys Leu Cys Cys Arg Ala Thr Gly His Pro Phe Val Gln Tyr Gln Trp 
145                 150                 155                 160 


Phe Lys Met Asn Lys Glu Ile Pro Asn Gly Asn Thr Ser Glu Leu Ile 
                165                 170                 175     


Phe Asn Ala Val His Val Lys Asp Ala Gly Phe Tyr Val Cys Arg Val 
            180                 185                 190         


Asn Asn Asn Phe Thr Phe Glu Phe Ser Gln Trp Ser Gln Leu Asp Val 
        195                 200                 205             


Cys Asp Ile Pro Glu Ser Phe Gln Arg Ser Val Asp Gly Val Ser Glu 
    210                 215                 220                 


Ser Lys Leu Gln Ile Cys Val Glu Pro Thr Ser Gln Lys Leu Met Pro 
225                 230                 235                 240 


Gly Ser Thr Leu Val Leu Gln Cys Val Ala Val Gly Ser Pro Ile Pro 
                245                 250                 255     


His Tyr Gln Trp Phe Lys Asn Glu Leu Pro Leu Thr His Glu Thr Lys 
            260                 265                 270         


Lys Leu Tyr Met Val Pro Tyr Val Asp Leu Glu His Gln Gly Thr Tyr 
        275                 280                 285             


Trp Cys His Val Tyr Asn Asp Arg Asp Ser Gln Asp Ser Lys Lys Val 
    290                 295                 300                 


Glu Ile Ile Ile Asp Glu Leu Asn Asn Leu Gly His Pro Asp Asn Lys 
305                 310                 315                 320 


Glu Gln Thr Thr Asp Gln Pro Leu Ala Lys Asp Lys Val Ala Leu Leu 
                325                 330                 335     


Ile Gly Asn Met Asn Tyr Arg Glu His Pro Lys Leu Lys Ala Pro Leu 
            340                 345                 350         


Val Asp Val Tyr Glu Leu Thr Asn Leu Leu Arg Gln Leu Asp Phe Lys 
        355                 360                 365             


Val Val Ser Leu Leu Asp Leu Thr Glu Tyr Glu Met Arg Asn Ala Val 
    370                 375                 380                 


Asp Glu Phe Leu Leu Leu Leu Asp Lys Gly Val Tyr Gly Leu Leu Tyr 
385                 390                 395                 400 


Tyr Ala Gly His Gly Tyr Glu Asn Phe Gly Asn Ser Phe Met Val Pro 
                405                 410                 415     


Val Asp Ala Pro Asn Pro Tyr Arg Ser Glu Asn Cys Leu Cys Val Gln 
            420                 425                 430         


Asn Ile Leu Lys Leu Met Gln Glu Lys Glu Thr Gly Leu Asn Val Phe 
        435                 440                 445             


Leu Leu Asp Met Cys Arg Lys Arg Asn Asp Tyr Asp Asp Thr Ile Pro 
    450                 455                 460                 


Ile Leu Asp Ala Leu Lys Val Thr Ala Asn Ile Val Phe Gly Tyr Ala 
465                 470                 475                 480 


Thr Cys Gln Gly Ala Glu Ala Phe Glu Ile Gln His Ser Gly Leu Ala 
                485                 490                 495     


Asn Gly Ile Phe Met Lys Phe Leu Lys Asp Arg Leu Leu Glu Asp Lys 
            500                 505                 510         


Lys Ile Thr Val Leu Leu Asp Glu Val Ala Glu Asp Met Gly Lys Cys 
        515                 520                 525             


His Leu Thr Lys Gly Lys Gln Ala Leu Glu Ile Arg Ser Ser Leu Ser 
    530                 535                 540                 


Glu Lys Arg Ala Leu Thr Asp Pro Ile Gln Gly Thr Glu Tyr Ser Ala 
545                 550                 555                 560 


Glu Ser Leu Val Arg Asn Leu Gln Trp Ala Lys Ala His Glu Leu Pro 
                565                 570                 575     


Glu Ser Met Cys Leu Lys Phe Asp Cys Gly Val Gln Ile Gln Leu Gly 
            580                 585                 590         


Phe Ala Ala Glu Phe Ser Asn Val Met Ile Ile Tyr Thr Ser Ile Val 
        595                 600                 605             


Tyr Lys Pro Pro Glu Ile Ile Met Cys Asp Ala Tyr Val Thr Asp Phe 
    610                 615                 620                 


Pro Leu Asp Leu Asp Ile Asp Pro Lys Asp Ala Asn Lys Gly Thr Pro 
625                 630                 635                 640 


Glu Glu Thr Gly Ser Tyr Leu Val Ser Lys Asp Leu Pro Lys His Cys 
                645                 650                 655     


Leu Tyr Thr Arg Leu Ser Ser Leu Gln Lys Leu Lys Glu His Leu Val 
            660                 665                 670         


Phe Thr Val Cys Leu Ser Tyr Gln Tyr Ser Gly Leu Glu Asp Thr Val 
        675                 680                 685             


Glu Asp Lys Gln Glu Val Asn Val Gly Lys Pro Leu Ile Ala Lys Leu 
    690                 695                 700                 


Asp Met His Arg Gly Leu Gly Arg Lys Thr Cys Phe Gln Thr Cys Leu 
705                 710                 715                 720 


Met Ser Asn Gly Pro Tyr Gln Ser Ser Ala Ala Thr Ser Gly Gly Ala 
                725                 730                 735     


Gly His Tyr His Ser Leu Gln Asp Pro Phe His Gly Val Tyr His Ser 
            740                 745                 750         


His Pro Gly Asn Pro Ser Asn Val Thr Pro Ala Asp Ser Cys His Cys 
        755                 760                 765             


Ser Arg Thr Pro Asp Ala Phe Ile Ser Ser Phe Ala His His Ala Ser 
    770                 775                 780                 


Cys His Phe Ser Arg Ser Asn Val Pro Val Glu Thr Thr Asp Glu Ile 
785                 790                 795                 800 


Pro Phe Ser Phe Ser Asp Arg Leu Arg Ile Ser Glu Lys 
                805                 810             


