                         SEQUENCE LISTING

<110>  йžҽѧѧԺҽѧо
 
<120>  һTim-3 źͨ·Tim-3ںϵ

<160>  6     

<170>  PatentIn version 3.3

<210>  1
<211>  440
<212>  PRT
<213>  ˹

<400>  1

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln 
            20                  25                  30          


Asn Ala Tyr Leu Pro Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu 
        35                  40                  45              


Val Pro Val Cys Trp Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly 
    50                  55                  60                  


Asn Val Val Leu Arg Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser 
65                  70                  75                  80  


Arg Tyr Trp Leu Asn Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr 
                85                  90                  95      


Ile Glu Asn Val Thr Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile 
            100                 105                 110         


Gln Ile Pro Gly Ile Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val 
        115                 120                 125             


Ile Lys Pro Ala Lys Val Thr Pro Ala Pro Thr Leu Gln Arg Asp Phe 
    130                 135                 140                 


Thr Ala Ala Phe Pro Arg Met Leu Thr Thr Arg Gly His Gly Pro Ala 
145                 150                 155                 160 


Glu Thr Gln Thr Leu Gly Ser Leu Pro Asp Ile Asn Leu Thr Gln Ile 
                165                 170                 175     


Ser Thr Leu Ala Asn Glu Leu Arg Asp Ser Arg Leu Ala Asn Asp Leu 
            180                 185                 190         


Arg Asp Ser Gly Ala Thr Ile Arg Ile Gly Ala Ser Met Thr Gly Gly 
        195                 200                 205             


Gln Gln Met Gly Arg Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    210                 215                 220                 


Ser Gly Gly Gly Gly Ser Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
225                 230                 235                 240 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                245                 250                 255     


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
            260                 265                 270         


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        275                 280                 285             


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
    290                 295                 300                 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
305                 310                 315                 320 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                325                 330                 335     


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
            340                 345                 350         


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
        355                 360                 365             


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
    370                 375                 380                 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
385                 390                 395                 400 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
                405                 410                 415     


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            420                 425                 430         


Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440 


<210>  2
<211>  1323
<212>  DNA
<213>  ˹

<400>  2
atgggcagca gccatcatca tcatcatcac agcagcggcc tggtgccgcg cggcagccat     60

atgtcagaag tggaatacag agcggaggtc ggtcagaatg cctatctgcc ctgcttctac    120

accccagccg ccccagggaa cctcgtgccc gtctgctggg gcaaaggagc ctgtcctgtg    180

tttgaatgtg gcaacgtggt gctcaggact gatgaaaggg atgtgaatta ttggacatcc    240

agatactggc taaatgggga tttccgcaaa ggagatgtgt ccctgaccat agagaatgtg    300

actctagcag acagtgggat ctactgctgc cggatccaaa tcccaggcat aatgaatgat    360

gaaaaattta acctgaagtt ggtcatcaaa ccagccaagg tcacccctgc accgactctg    420

cagagagact tcactgcagc ctttccaagg atgcttacca ccaggggaca tggcccagca    480

gagacacaga cactggggag cctccctgat ataaatctaa cacaaatatc cacattggcc    540

aatgagttac gggactctag attggccaat gacttacggg actctggagc aaccatcaga    600

ataggcgcta gcatgactgg tggacagcaa atgggtcgcg gatccggtgg cggtggctcg    660

ggcggtggtg ggtcgggtgg cggcggatct ccgtcagtct tcctcttccc cccaaaaccc    720

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc    780

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc    840

aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc    900

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc    960

ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag   1020

gtgtacaccc tgcccccatc ccgggaggag atgaccaaga accaggtcag cctgacctgc   1080

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg   1140

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctat   1200

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg   1260

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaaa   1320

taa                                                                 1323


<210>  3
<211>  1680
<212>  DNA
<213>  ˹

<400>  3
atgggcagca gccatcatca tcatcatcac agcagcggcc tggtgccgcg cggcagccat     60

atgtcagaag tggaatacag agcggaggtc ggtcagaatg cctatctgcc ctgcttctac    120

accccagccg ccccagggaa cctcgtgccc gtctgctggg gcaaaggagc ctgtcctgtg    180

tttgaatgtg gcaacgtggt gctcaggact gatgaaaggg atgtgaatta ttggacatcc    240

agatactggc taaatgggga tttccgcaaa ggagatgtgt ccctgaccat agagaatgtg    300

actctagcag acagtgggat ctactgctgc cggatccaaa tcccaggcat aatgaatgat    360

gaaaaattta acctgaagtt ggtcatcaaa ccagccaagg tcacccctgc accgactctg    420

cagagagact tcactgcagc ctttccaagg atgcttacca ccaggggaca tggcccagca    480

gagacacaga cactggggag cctccctgat ataaatctaa cacaaatatc cacattggcc    540

aatgagttac gggactctag attggccaat gacttacggg actctggagc aaccatcaga    600

ataggcgcta gcatgactgg tggacagcaa atgggtcgcg gatccggtgg cggtggctcg    660

ggcggtggtg ggtcgggtgg cggcggatct tccaccaagg gcccatcggt cttccccctg    720

gcaccctcct ccaagagcac ctctgggggc acagcggccc tgggctgcct ggtcaaggac    780

tacttccccg aaccggtgac ggtgtcgtgg aactcaggcg ccctgaccag cggcgtgcac    840

accttcccgg ctgtcctaca gtcctcagga ctctactccc tcagcagcgt ggtgaccgtg    900

ccctccagca gcttgggcac ccagacctac atctgcaacg tgaatcacaa gcccagcaac    960

accaaggtgg acaagagagt tgagcccaaa tcttgtgaca aaactcacac atgcccaccg   1020

tgcccagcac ctgaactcct ggggggaccg tcagtcttcc tcttcccccc aaaacccaag   1080

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac   1140

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag   1200

acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc   1260

ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc   1320

ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg   1380

tacaccctgc ccccatcccg ggaggagatg accaagaacc aggtcagcct gacctgcctg   1440

gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag   1500

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctatagc   1560

aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg   1620

catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtcccc gggtaaatga   1680


<210>  4
<211>  1386
<212>  DNA
<213>  ˹

<400>  4
atgggcagca gccatcatca tcatcatcac agcagcggcc tggtgccgcg cggcagccat     60

atgtcagaag tggaatacag agcggaggtc ggtcagaatg cctatctgcc ctgcttctac    120

accccagccg ccccagggaa cctcgtgccc gtctgctggg gcaaaggagc ctgtcctgtg    180

tttgaatgtg gcaacgtggt gctcaggact gatgaaaggg atgtgaatta ttggacatcc    240

agatactggc taaatgggga tttccgcaaa ggagatgtgt ccctgaccat agagaatgtg    300

actctagcag acagtgggat ctactgctgc cggatccaaa tcccaggcat aatgaatgat    360

gaaaaattta acctgaagtt ggtcatcaaa ccagccaagg tcacccctgc accgactctg    420

cagagagact tcactgcagc ctttccaagg atgcttacca ccaggggaca tggcccagca    480

gagacacaga cactggggag cctccctgat ataaatctaa cacaaatatc cacattggcc    540

aatgagttac gggactctag attggccaat gacttacggg actctggagc aaccatcaga    600

ataggcgcta gcatgactgg tggacagcaa atgggtcgcg gatccggtgg cggtggctcg    660

ggcggtggtg ggtcgggtgg cggcggatct cccaaatctt gtgacaaaac tcacacatgc    720

ccaccgtgcc cagcacctga actcctgggg ggaccgtcag tcttcctctt ccccccaaaa    780

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg    840

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat    900

gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc    960

accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa   1020

gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca   1080

caggtgtaca ccctgccccc atcccgggag gagatgacca agaaccaggt cagcctgacc   1140

tgcctggtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag caatgggcag   1200

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc   1260

tatagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc   1320

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtccccgggt   1380

aaatga                                                              1386


<210>  5
<211>  1323
<212>  DNA
<213>  ˹

<400>  5
atgggcagca gccatcatca tcatcatcac agcagcggcc tggtgccgcg cggcagccat     60

atggaatgtg gcaacgtggt gctcaggact gatgaaaggg atgtgaatta ttggacatcc    120

agatactggc taaatgggga tttccgcaaa ggagatgtgt ccctgaccat agagaatgtg    180

actctagcag acagtgggat ctactgctgc cggatccaaa tcccaggcat aatgaatgat    240

gaaaaattta acctgaagtt ggtcatcaaa ccagccaagg tcacccctgc accgactctg    300

cagagagact tcactgcagc ctttccaagg atgcttacca ccaggggaca tggcccagca    360

gagacacaga cactggggag cctccctgat ataaatctaa cacaaatatc cacattggcc    420

aatgagttac gggactctag attggccaat gacttacggg actctggagc aaccatcaga    480

ataggcatct acatcggagc agggatctgt gctgggctgg ctctggctct tatcttcggc    540

gctttaattt tcaaatggta ttctcatagc aaagagaaga tacagaattt aagcctcatc    600

tctttggcta gcatgactgg tggacagcaa atgggtcgcg gatccggtgg cggtggctcg    660

ggcggtggtg ggtcgggtgg cggcggatct ccgtcagtct tcctcttccc cccaaaaccc    720

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc    780

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc    840

aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc    900

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc    960

ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag   1020

gtgtacaccc tgcccccatc ccgggaggag atgaccaaga accaggtcag cctgacctgc   1080

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg   1140

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctat   1200

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg   1260

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaaa   1320

taa                                                                 1323


<210>  6
<211>  1323
<212>  DNA
<213>  ˹

<400>  6
atgggcagca gccatcatca tcatcatcac agcagcggcc tggtgccgcg cggcagccat     60

atgctagcag acagtgggat ctactgctgc cggatccaaa tcccaggcat aatgaatgat    120

gaaaaattta acctgaagtt ggtcatcaaa ccagccaagg tcacccctgc accgactctg    180

cagagagact tcactgcagc ctttccaagg atgcttacca ccaggggaca tggcccagca    240

gagacacaga cactggggag cctccctgat ataaatctaa cacaaatatc cacattggcc    300

aatgagttac gggactctag attggccaat gacttacggg actctggagc aaccatcaga    360

ataggcatct acatcggagc agggatctgt gctgggctgg ctctggctct tatcttcggc    420

gctttaattt tcaaatggta ttctcatagc aaagagaaga tacagaattt aagcctcatc    480

tctttggcca acctccctcc ctcaggattg gcaaatgcag tagcagaggg aattcgctca    540

gaagaaaaca tctataccat tgaagagaac gtatatgaag tggaggagcc caatgagtat    600

tattgcgcta gcatgactgg tggacagcaa atgggtcgcg gatccggtgg cggtggctcg    660

ggcggtggtg ggtcgggtgg cggcggatct ccgtcagtct tcctcttccc cccaaaaccc    720

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc    780

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc    840

aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc    900

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc    960

ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag   1020

gtgtacaccc tgcccccatc ccgggaggag atgaccaaga accaggtcag cctgacctgc   1080

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg   1140

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctat   1200

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg   1260

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaaa   1320

taa                                                                 1323

