                         SEQUENCE LISTING

<110>  Calysta, Inc.
       Silverman, Joshua A.
       Giver, Lorraine Joan
       Mueller, Jana
       Saville, Renee M.
       Regitsky, Drew D.
 
<120>  Carbohydrate-Enriched Recombinant Microorganisms

<130>  200206.416WO

<150>  US 61/928,366
<151>  2014-01-16

<160>  38    

<170>  PatentIn version 3.5

<210>  1
<211>  852
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  CDS
<222>  (1)..(852)
<223>  Saccharomyces cerevisiae mature KRE1 protein  (codon optimized)

<400>  1
gtc atg gcc gct gtt acc acc caa gtc acc gtc gtc acc aat gtt gct         48
Val Met Ala Ala Val Thr Thr Gln Val Thr Val Val Thr Asn Val Ala           
1               5                   10                  15                

gga gcc ctt gtc acc gaa acc acc atc tgg gac ccc gcg acc gcc gca         96
Gly Ala Leu Val Thr Glu Thr Thr Ile Trp Asp Pro Ala Thr Ala Ala           
            20                  25                  30                    

gcc gca gcg acg acc acc gcc cag acg ggc ttc ttc acc acc gtg ttc        144
Ala Ala Ala Thr Thr Thr Ala Gln Thr Gly Phe Phe Thr Thr Val Phe           
        35                  40                  45                        

acg acc acc aac gac gtg ggt acc act gtc acg ctg acg cag acc gtg        192
Thr Thr Thr Asn Asp Val Gly Thr Thr Val Thr Leu Thr Gln Thr Val           
    50                  55                  60                            

aat cgc gcc acg atg ctg ccc act acc acg acg agc acc agc agc acc        240
Asn Arg Ala Thr Met Leu Pro Thr Thr Thr Thr Ser Thr Ser Ser Thr           
65                  70                  75                  80            

ggc aag acc acc acg acg gtg ccg act gcg acg tcc tcg ctc agt tcg        288
Gly Lys Thr Thr Thr Thr Val Pro Thr Ala Thr Ser Ser Leu Ser Ser           
                85                  90                  95                

ggc ctg tcg acc gtc acc acc acg aac gac ctg ggc acg acc gtg acg        336
Gly Leu Ser Thr Val Thr Thr Thr Asn Asp Leu Gly Thr Thr Val Thr           
            100                 105                 110                   

ctc acc cag acc ttc acg cac tcc tcc acg tcc gcg acc tcc tcg gcc        384
Leu Thr Gln Thr Phe Thr His Ser Ser Thr Ser Ala Thr Ser Ser Ala           
        115                 120                 125                       

tcc tcg tcg gtg agc tcg tcc gtc agt agc agt ggc tcc tcc agc agc        432
Ser Ser Ser Val Ser Ser Ser Val Ser Ser Ser Gly Ser Ser Ser Ser           
    130                 135                 140                           

gtc aag acc acg acc tcg acc ggc tcc gcg gtg gcg gaa acc ggg tgg        480
Val Lys Thr Thr Thr Ser Thr Gly Ser Ala Val Ala Glu Thr Gly Trp           
145                 150                 155                 160           

gac ccg agc acg gat ttt acc gag ccg cca gtg agc gcg gtc acc agc        528
Asp Pro Ser Thr Asp Phe Thr Glu Pro Pro Val Ser Ala Val Thr Ser           
                165                 170                 175               

ctc tcg atc gac tcg tat ata acg atc acc gag ggc acc acc tcg acc        576
Leu Ser Ile Asp Ser Tyr Ile Thr Ile Thr Glu Gly Thr Thr Ser Thr           
            180                 185                 190                   

tac act acc acc cgg gcg ccg acc tcg atg tgg gtg acc gtc gtc cgc        624
Tyr Thr Thr Thr Arg Ala Pro Thr Ser Met Trp Val Thr Val Val Arg           
        195                 200                 205                       

cag ggg aac acg atc acc gtg caa acc acc ttc gtc cag cgc ttc agc        672
Gln Gly Asn Thr Ile Thr Val Gln Thr Thr Phe Val Gln Arg Phe Ser           
    210                 215                 220                           

tcc caa tac gtg acc gtg gat tcc gtc ggc agc atc ggc atg ggt acg        720
Ser Gln Tyr Val Thr Val Asp Ser Val Gly Ser Ile Gly Met Gly Thr           
225                 230                 235                 240           

ctg acc ggt acc gtc ggc gtg atc aag tcc gcc atc aag aaa acc gtg        768
Leu Thr Gly Thr Val Gly Val Ile Lys Ser Ala Ile Lys Lys Thr Val           
                245                 250                 255               

tcc cat aac gag gcc cag cat ctc ggc atg tcg tcg ttc acg tcg att        816
Ser His Asn Glu Ala Gln His Leu Gly Met Ser Ser Phe Thr Ser Ile           
            260                 265                 270                   

ctg ggt ggc ctc ctc acg gtc ttg atc tgg ttc ctg                        852
Leu Gly Gly Leu Leu Thr Val Leu Ile Trp Phe Leu                           
        275                 280                                           


<210>  2
<211>  284
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  2

Val Met Ala Ala Val Thr Thr Gln Val Thr Val Val Thr Asn Val Ala 
1               5                   10                  15      


Gly Ala Leu Val Thr Glu Thr Thr Ile Trp Asp Pro Ala Thr Ala Ala 
            20                  25                  30          


Ala Ala Ala Thr Thr Thr Ala Gln Thr Gly Phe Phe Thr Thr Val Phe 
        35                  40                  45              


Thr Thr Thr Asn Asp Val Gly Thr Thr Val Thr Leu Thr Gln Thr Val 
    50                  55                  60                  


Asn Arg Ala Thr Met Leu Pro Thr Thr Thr Thr Ser Thr Ser Ser Thr 
65                  70                  75                  80  


Gly Lys Thr Thr Thr Thr Val Pro Thr Ala Thr Ser Ser Leu Ser Ser 
                85                  90                  95      


Gly Leu Ser Thr Val Thr Thr Thr Asn Asp Leu Gly Thr Thr Val Thr 
            100                 105                 110         


Leu Thr Gln Thr Phe Thr His Ser Ser Thr Ser Ala Thr Ser Ser Ala 
        115                 120                 125             


Ser Ser Ser Val Ser Ser Ser Val Ser Ser Ser Gly Ser Ser Ser Ser 
    130                 135                 140                 


Val Lys Thr Thr Thr Ser Thr Gly Ser Ala Val Ala Glu Thr Gly Trp 
145                 150                 155                 160 


Asp Pro Ser Thr Asp Phe Thr Glu Pro Pro Val Ser Ala Val Thr Ser 
                165                 170                 175     


Leu Ser Ile Asp Ser Tyr Ile Thr Ile Thr Glu Gly Thr Thr Ser Thr 
            180                 185                 190         


Tyr Thr Thr Thr Arg Ala Pro Thr Ser Met Trp Val Thr Val Val Arg 
        195                 200                 205             


Gln Gly Asn Thr Ile Thr Val Gln Thr Thr Phe Val Gln Arg Phe Ser 
    210                 215                 220                 


Ser Gln Tyr Val Thr Val Asp Ser Val Gly Ser Ile Gly Met Gly Thr 
225                 230                 235                 240 


Leu Thr Gly Thr Val Gly Val Ile Lys Ser Ala Ile Lys Lys Thr Val 
                245                 250                 255     


Ser His Asn Glu Ala Gln His Leu Gly Met Ser Ser Phe Thr Ser Ile 
            260                 265                 270         


Leu Gly Gly Leu Leu Thr Val Leu Ile Trp Phe Leu 
        275                 280                 


<210>  3
<211>  4065
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  CDS
<222>  (1)..(4065)
<223>  Saccharomyces cerevisiae  mature KRE2 protein (codon optimized)

<400>  3
atg cgc ctt ctt gcc ctt gtc ttg ttg ctt ctc tgt gca ccg ctt cgc         48
Met Arg Leu Leu Ala Leu Val Leu Leu Leu Leu Cys Ala Pro Leu Arg           
1               5                   10                  15                

gcc tgg acc tat tcg ctc cgc tat ggt atc ccc gag tcc gcc cag gtg         96
Ala Trp Thr Tyr Ser Leu Arg Tyr Gly Ile Pro Glu Ser Ala Gln Val           
            20                  25                  30                    

tgg tcg atc ctc gtt cat ctg ctc ggc gac gtg gac aac caa ctc ctt        144
Trp Ser Ile Leu Val His Leu Leu Gly Asp Val Asp Asn Gln Leu Leu           
        35                  40                  45                        

act aac ctg tat ccc ctg gtg acc ggg ctc gac gat gag atc gac atc        192
Thr Asn Leu Tyr Pro Leu Val Thr Gly Leu Asp Asp Glu Ile Asp Ile           
    50                  55                  60                            

cag gag aac ctc gtt acg tcc aac gtg ctg cgc gag cgc tac gat aaa        240
Gln Glu Asn Leu Val Thr Ser Asn Val Leu Arg Glu Arg Tyr Asp Lys           
65                  70                  75                  80            

gag gac gtc gcg gat ctg ctg gaa ctc tac gca tcg ctc tac ccc atg        288
Glu Asp Val Ala Asp Leu Leu Glu Leu Tyr Ala Ser Leu Tyr Pro Met           
                85                  90                  95                

ggg atg atc caa cac gac atc tcg tcg aat gcc gag caa gac gac gcg        336
Gly Met Ile Gln His Asp Ile Ser Ser Asn Ala Glu Gln Asp Asp Ala           
            100                 105                 110                   

aat tcc tcc tat ttc gtc ctg aac ggc aat cgg tat gag aaa ccc gac        384
Asn Ser Ser Tyr Phe Val Leu Asn Gly Asn Arg Tyr Glu Lys Pro Asp           
        115                 120                 125                       

gac gtc ttt tac ctg aag tcg aag gac ctg acc atc cag cag aaa gtg        432
Asp Val Phe Tyr Leu Lys Ser Lys Asp Leu Thr Ile Gln Gln Lys Val           
    130                 135                 140                           

ccc gat gtc gac gtc atc caa ccg tac gac gtc gtg att gga acc aac        480
Pro Asp Val Asp Val Ile Gln Pro Tyr Asp Val Val Ile Gly Thr Asn           
145                 150                 155                 160           

tcc gag gcg ccc ata ctg atc ctc tac ggc tgc ccg acc gtc atc gac        528
Ser Glu Ala Pro Ile Leu Ile Leu Tyr Gly Cys Pro Thr Val Ile Asp           
                165                 170                 175               

agc gac ttc gag gag ttc aat cgg aat ctc ttc atg gag gct atg aac        576
Ser Asp Phe Glu Glu Phe Asn Arg Asn Leu Phe Met Glu Ala Met Asn           
            180                 185                 190                   

ggc gag ggc aag ttc cgc ttc att tgg cgg agc acg tgt agc ctg gac        624
Gly Glu Gly Lys Phe Arg Phe Ile Trp Arg Ser Thr Cys Ser Leu Asp           
        195                 200                 205                       

ggc aag tcc gtg gag tac ccg ctg acc cac ccc ctg gag atc acc ctg        672
Gly Lys Ser Val Glu Tyr Pro Leu Thr His Pro Leu Glu Ile Thr Leu           
    210                 215                 220                           

cag aac ggc agc cgc atg tcc tcc atc cct cag ctc aag aag atc ctg        720
Gln Asn Gly Ser Arg Met Ser Ser Ile Pro Gln Leu Lys Lys Ile Leu           
225                 230                 235                 240           

tac acc gtt ccg aaa gaa atc ctc gtg ggc gca gat aac gac gac cag        768
Tyr Thr Val Pro Lys Glu Ile Leu Val Gly Ala Asp Asn Asp Asp Gln           
                245                 250                 255               

ctg cac gac ctg gag ccc gag gag ctg cgc gag ctg gac ctc cgc gtg        816
Leu His Asp Leu Glu Pro Glu Glu Leu Arg Glu Leu Asp Leu Arg Val           
            260                 265                 270                   

acc tcg ctc att tcc gag ttc tat cag tat aag aaa gac att acg gcc        864
Thr Ser Leu Ile Ser Glu Phe Tyr Gln Tyr Lys Lys Asp Ile Thr Ala           
        275                 280                 285                       

acc ctg aat ttc acc aaa agt atc gtc aac aat ttc ccg ctg att tcg        912
Thr Leu Asn Phe Thr Lys Ser Ile Val Asn Asn Phe Pro Leu Ile Ser           
    290                 295                 300                           

aag cag ctg atc aag gtt tcg tcg gtc aat aaa gac atc atc acc tcc        960
Lys Gln Leu Ile Lys Val Ser Ser Val Asn Lys Asp Ile Ile Thr Ser           
305                 310                 315                 320           

aac gag gag ttg aat tcc aag ggc ttc gac tac aac atg ctg ggc atc       1008
Asn Glu Glu Leu Asn Ser Lys Gly Phe Asp Tyr Asn Met Leu Gly Ile           
                325                 330                 335               

aac ggc cag aac tgg aag atc acc tcc ctg acg ccc tac aat ctt ctc       1056
Asn Gly Gln Asn Trp Lys Ile Thr Ser Leu Thr Pro Tyr Asn Leu Leu           
            340                 345                 350                   

acg gcc ctg aaa acg gag tac cag agt ctg ctg aag atc acc aac ctc       1104
Thr Ala Leu Lys Thr Glu Tyr Gln Ser Leu Leu Lys Ile Thr Asn Leu           
        355                 360                 365                       

ctc cag gag ctg gag ccc tcc aag tgc atc ctc gac tcc aag ttc ctg       1152
Leu Gln Glu Leu Glu Pro Ser Lys Cys Ile Leu Asp Ser Lys Phe Leu           
    370                 375                 380                           

ctc aat aag ttc tcg cag ttc agc ctg ggt aaa ctg cag aat ctg caa       1200
Leu Asn Lys Phe Ser Gln Phe Ser Leu Gly Lys Leu Gln Asn Leu Gln           
385                 390                 395                 400           

ccg atc aaa atg gac ctc cat acc atc ccg ggt ttt agc gag tcc gtc       1248
Pro Ile Lys Met Asp Leu His Thr Ile Pro Gly Phe Ser Glu Ser Val           
                405                 410                 415               

atc tac ttc aat gat att gag agt gac ccg cag tac gac gag ctc gtc       1296
Ile Tyr Phe Asn Asp Ile Glu Ser Asp Pro Gln Tyr Asp Glu Leu Val           
            420                 425                 430                   

aac tcg gtg caa gca ttc ttc gac aag tcg aag ttc ggc gag ctg ccc       1344
Asn Ser Val Gln Ala Phe Phe Asp Lys Ser Lys Phe Gly Glu Leu Pro           
        435                 440                 445                       

gag atc aag cag aac tgg tcc gag att atc ttc gtc ata gat ttt gcc       1392
Glu Ile Lys Gln Asn Trp Ser Glu Ile Ile Phe Val Ile Asp Phe Ala           
    450                 455                 460                           

cgg ctg gag gac tcg gaa gtc aaa gag gcc ctc ggc gga ctg gtg agg       1440
Arg Leu Glu Asp Ser Glu Val Lys Glu Ala Leu Gly Gly Leu Val Arg           
465                 470                 475                 480           

gct gtg aac gtc gtg agc cag ggg tac ccc cag cgc gtg gga ctc ctc       1488
Ala Val Asn Val Val Ser Gln Gly Tyr Pro Gln Arg Val Gly Leu Leu           
                485                 490                 495               

ccg ttc agc agt gat agc gac aag agc gtc gtc aat aag atc tac gag       1536
Pro Phe Ser Ser Asp Ser Asp Lys Ser Val Val Asn Lys Ile Tyr Glu           
            500                 505                 510                   

ctg aag aac tcg acc gac aat ctc acc gag ctg aag tcg ttc ctg gaa       1584
Leu Lys Asn Ser Thr Asp Asn Leu Thr Glu Leu Lys Ser Phe Leu Glu           
        515                 520                 525                       

acc atg ttg ctg gcc gac ggc ctg tcc gcc aac gcg aag cat agt aag       1632
Thr Met Leu Leu Ala Asp Gly Leu Ser Ala Asn Ala Lys His Ser Lys           
    530                 535                 540                           

cat atc ccc gtg ccg gac gtg ttc cac ctc ctc gac gag ctg cag atc       1680
His Ile Pro Val Pro Asp Val Phe His Leu Leu Asp Glu Leu Gln Ile           
545                 550                 555                 560           

gac gaa acg tcc atc atc atc aac ggc gag ata tac ccg ttc cgc aag       1728
Asp Glu Thr Ser Ile Ile Ile Asn Gly Glu Ile Tyr Pro Phe Arg Lys           
                565                 570                 575               

aat tgg aac tac ctc atc gcc aag gtc atc aag aaa gac acc gaa ttc       1776
Asn Trp Asn Tyr Leu Ile Ala Lys Val Ile Lys Lys Asp Thr Glu Phe           
            580                 585                 590                   

atc cgc aag gag ctg tcg aac tcg tcg ccg aag aac aag cag att agt       1824
Ile Arg Lys Glu Leu Ser Asn Ser Ser Pro Lys Asn Lys Gln Ile Ser           
        595                 600                 605                       

gtg cgc gac ctg ttg cac tat aag agc gcg aac ctc cgc cat aac aag       1872
Val Arg Asp Leu Leu His Tyr Lys Ser Ala Asn Leu Arg His Asn Lys           
    610                 615                 620                           

tat acg ccg aac tat ttc gcg gat agt gtg tat tcc tcg gtc aac aat       1920
Tyr Thr Pro Asn Tyr Phe Ala Asp Ser Val Tyr Ser Ser Val Asn Asn           
625                 630                 635                 640           

acc gct ctg gaa agc gtc tgc tcg atc ggt tac tac acc aaa aac gag       1968
Thr Ala Leu Glu Ser Val Cys Ser Ile Gly Tyr Tyr Thr Lys Asn Glu           
                645                 650                 655               

gaa tat aac ctc ctg cat acc att acg ctc gtg gat gac ttc ggc tcg       2016
Glu Tyr Asn Leu Leu His Thr Ile Thr Leu Val Asp Asp Phe Gly Ser           
            660                 665                 670                   

atc cat gcg ctg aag cgg ctg cgg aac ctg ttg cat acg tcc ttc gtg       2064
Ile His Ala Leu Lys Arg Leu Arg Asn Leu Leu His Thr Ser Phe Val           
        675                 680                 685                       

ggc gtg cgg atc cgc att atc cat gtc ggc gat atc agc gac atc tgg       2112
Gly Val Arg Ile Arg Ile Ile His Val Gly Asp Ile Ser Asp Ile Trp           
    690                 695                 700                           

tat cag ctc cgc gga tcc ctg agt cag aaa gac ccg atc ggc agc atc       2160
Tyr Gln Leu Arg Gly Ser Leu Ser Gln Lys Asp Pro Ile Gly Ser Ile           
705                 710                 715                 720           

aac acc ttc atc gac gcc ctg aaa ctc aaa aag gtc aag tcc cat acg       2208
Asn Thr Phe Ile Asp Ala Leu Lys Leu Lys Lys Val Lys Ser His Thr           
                725                 730                 735               

tat aag aag tcg cag cag ctc ggc ttg cat aag tgg ctc ccc gac atc       2256
Tyr Lys Lys Ser Gln Gln Leu Gly Leu His Lys Trp Leu Pro Asp Ile           
            740                 745                 750                   

ccg ctg ttc gag ctc caa aag ggt tcg ttc atc gcg ctc aac ggc cgg       2304
Pro Leu Phe Glu Leu Gln Lys Gly Ser Phe Ile Ala Leu Asn Gly Arg           
        755                 760                 765                       

ttc atc atc ctg atc aag atg aaa tgc cag aag caa aac atc tcc aaa       2352
Phe Ile Ile Leu Ile Lys Met Lys Cys Gln Lys Gln Asn Ile Ser Lys           
    770                 775                 780                           

gcc aag atc atc aag cgc gag gcc ctt cgg acc ata gat tcg gtg ttc       2400
Ala Lys Ile Ile Lys Arg Glu Ala Leu Arg Thr Ile Asp Ser Val Phe           
785                 790                 795                 800           

gcg ctg gac ctc ctc ttt cct ggc ttc agc caa gag atc ata aat ccc       2448
Ala Leu Asp Leu Leu Phe Pro Gly Phe Ser Gln Glu Ile Ile Asn Pro           
                805                 810                 815               

gat ctc atc gag atg atc tcc tcg atc ctt acc cgc ctc ttc tat cag       2496
Asp Leu Ile Glu Met Ile Ser Ser Ile Leu Thr Arg Leu Phe Tyr Gln           
            820                 825                 830                   

ggg acc cac ata tac aac aac ggc att gac tat act acc gag tcg tcg       2544
Gly Thr His Ile Tyr Asn Asn Gly Ile Asp Tyr Thr Thr Glu Ser Ser           
        835                 840                 845                       

ctg ccg cgc atg gac ttg tcc gag ttc ttc cgc ccg aat aac ctg acc       2592
Leu Pro Arg Met Asp Leu Ser Glu Phe Phe Arg Pro Asn Asn Leu Thr           
    850                 855                 860                           

atg ttc gag gat ggc aaa tcg gcg tcc atc gat ctc ctc ctc atc ctt       2640
Met Phe Glu Asp Gly Lys Ser Ala Ser Ile Asp Leu Leu Leu Ile Leu           
865                 870                 875                 880           

gac ccg ctg gaa gaa cgg act cag atg att ctt tcc ctc gtg gag caa       2688
Asp Pro Leu Glu Glu Arg Thr Gln Met Ile Leu Ser Leu Val Glu Gln           
                885                 890                 895               

ttc cgg cca ctg aag ttc gtg aat atc cag gtc atc ctg atg ccg acc       2736
Phe Arg Pro Leu Lys Phe Val Asn Ile Gln Val Ile Leu Met Pro Thr           
            900                 905                 910                   

ctg gag ctg aat att gtc ccg atc cgg cgc atc tac gtg gac gac gcg       2784
Leu Glu Leu Asn Ile Val Pro Ile Arg Arg Ile Tyr Val Asp Asp Ala           
        915                 920                 925                       

gat atc gtc aag tcc atc acg tcc gag gac tcc cgg tcg gac cct gag       2832
Asp Ile Val Lys Ser Ile Thr Ser Glu Asp Ser Arg Ser Asp Pro Glu           
    930                 935                 940                           

gtt gac atc gag atg gat gtg ccg aac tcg ttc atc gtc gac aat aac       2880
Val Asp Ile Glu Met Asp Val Pro Asn Ser Phe Ile Val Asp Asn Asn           
945                 950                 955                 960           

tac agg att aag aaa ctg ttg att gag ctg cat tcg ttc tcc agt aaa       2928
Tyr Arg Ile Lys Lys Leu Leu Ile Glu Leu His Ser Phe Ser Ser Lys           
                965                 970                 975               

acc gtg ctg tcc acg ggc aat atc gac ggc atg ggt ggc gtg tgc ctt       2976
Thr Val Leu Ser Thr Gly Asn Ile Asp Gly Met Gly Gly Val Cys Leu           
            980                 985                 990                   

gcg ctc gtc gat tcg gct ggc aac  att atc gac aaa acc  acg acc atg     3024
Ala Leu Val Asp Ser Ala Gly Asn  Ile Ile Asp Lys Thr  Thr Thr Met         
        995                 1000                 1005                     

aaa acg  ttc ggg tac ggc cag  ttc cac acc gac aag  ttc ttg aag        3069
Lys Thr  Phe Gly Tyr Gly Gln  Phe His Thr Asp Lys  Phe Leu Lys            
    1010                 1015                 1020                        

ggt tgc  tac atc aaa agc tgc  gac agc cgc tat acc  gtc cag tcc        3114
Gly Cys  Tyr Ile Lys Ser Cys  Asp Ser Arg Tyr Thr  Val Gln Ser            
    1025                 1030                 1035                        

ttc agc  act gat ggc cac ccc  gat ttc atc ccg tcc  gac tcc ctc        3159
Phe Ser  Thr Asp Gly His Pro  Asp Phe Ile Pro Ser  Asp Ser Leu            
    1040                 1045                 1050                        

gac atc  ctg agc tat aac ccg  cag aag att gcg gtt  aag atc tcc        3204
Asp Ile  Leu Ser Tyr Asn Pro  Gln Lys Ile Ala Val  Lys Ile Ser            
    1055                 1060                 1065                        

gag gag  ccg acg cac gaa gaa  gag tat gaa gag ggt  cgc aat aac        3249
Glu Glu  Pro Thr His Glu Glu  Glu Tyr Glu Glu Gly  Arg Asn Asn            
    1070                 1075                 1080                        

gac acg  atc atc aat atc ttt  acc att tcg ggt ccc  gat gaa gaa        3294
Asp Thr  Ile Ile Asn Ile Phe  Thr Ile Ser Gly Pro  Asp Glu Glu            
    1085                 1090                 1095                        

gag agg  tac atg caa atg atc  ctg tcg atc ctc agc  aaa tgc cca        3339
Glu Arg  Tyr Met Gln Met Ile  Leu Ser Ile Leu Ser  Lys Cys Pro            
    1100                 1105                 1110                        

gaa acc  caa aaa gtg aat ttc  ttt ata ctg gac cag  ccg ttc att        3384
Glu Thr  Gln Lys Val Asn Phe  Phe Ile Leu Asp Gln  Pro Phe Ile            
    1115                 1120                 1125                        

tcg gac  acc ctg cgc aag tcc  tgc gaa tac atc aat  tcc agt gat        3429
Ser Asp  Thr Leu Arg Lys Ser  Cys Glu Tyr Ile Asn  Ser Ser Asp            
    1130                 1135                 1140                        

gag atg  cgc ggc aat gtc ata  ttc ctc aac tat gag  tgg ccc cag        3474
Glu Met  Arg Gly Asn Val Ile  Phe Leu Asn Tyr Glu  Trp Pro Gln            
    1145                 1150                 1155                        

tgg ctg  cgc cct cag cgg ttc  agc agc cgc agg cgc  gac gtc agc        3519
Trp Leu  Arg Pro Gln Arg Phe  Ser Ser Arg Arg Arg  Asp Val Ser            
    1160                 1165                 1170                        

cgg ttc  ctc ttc ctg gac gtg  ctc ctc ccg cag aac  atc agc aag        3564
Arg Phe  Leu Phe Leu Asp Val  Leu Leu Pro Gln Asn  Ile Ser Lys            
    1175                 1180                 1185                        

gtc ctc  tat atg tcg ccg acc  gag gtc ccg ctt gat  ccg ttc gac        3609
Val Leu  Tyr Met Ser Pro Thr  Glu Val Pro Leu Asp  Pro Phe Asp            
    1190                 1195                 1200                        

atc ttc  caa ttc cag ggc ctc  aag cgc gca ccg ctg  ggc ctg ttt        3654
Ile Phe  Gln Phe Gln Gly Leu  Lys Arg Ala Pro Leu  Gly Leu Phe            
    1205                 1210                 1215                        

cgc atg  agc ggt gac ggc tat  tgg aaa gag ggc tac  tgg gag aag        3699
Arg Met  Ser Gly Asp Gly Tyr  Trp Lys Glu Gly Tyr  Trp Glu Lys            
    1220                 1225                 1230                        

atg ctg  cgc gag aac aac ttg  gaa ttc tat agc acc  gag ccg gcg        3744
Met Leu  Arg Glu Asn Asn Leu  Glu Phe Tyr Ser Thr  Glu Pro Ala            
    1235                 1240                 1245                        

ttc ttg  gtc aat ctg gaa cgc  ttc cgc gag ctg gac  gcc ggc gac        3789
Phe Leu  Val Asn Leu Glu Arg  Phe Arg Glu Leu Asp  Ala Gly Asp            
    1250                 1255                 1260                        

aag tac  agg atc cat tac caa  cgc att agc acc gac  gcg atg agc        3834
Lys Tyr  Arg Ile His Tyr Gln  Arg Ile Ser Thr Asp  Ala Met Ser            
    1265                 1270                 1275                        

ctg gtg  aac atc ggg caa gac  ctc gtc aat aat ctg  caa ctt gag        3879
Leu Val  Asn Ile Gly Gln Asp  Leu Val Asn Asn Leu  Gln Leu Glu            
    1280                 1285                 1290                        

gtc ccg  atc cgg ttc ctg aag  ggt agt tat aag aaa  aag ctc gtg        3924
Val Pro  Ile Arg Phe Leu Lys  Gly Ser Tyr Lys Lys  Lys Leu Val            
    1295                 1300                 1305                        

atc aat  gat gag tgc gtc agc  gag tgg aag aaa aag  atc aac aag        3969
Ile Asn  Asp Glu Cys Val Ser  Glu Trp Lys Lys Lys  Ile Asn Lys            
    1310                 1315                 1320                        

ttt gcc  tcg tcc cca ggg gac  gag gac gtt ccc ggc  gag agt gtg        4014
Phe Ala  Ser Ser Pro Gly Asp  Glu Asp Val Pro Gly  Glu Ser Val            
    1325                 1330                 1335                        

agc tcg  aag tat cag gat tcg  gat aac gcc gcg cca  ctc cat gac        4059
Ser Ser  Lys Tyr Gln Asp Ser  Asp Asn Ala Ala Pro  Leu His Asp            
    1340                 1345                 1350                        

gaa ctc                                                               4065
Glu Leu                                                                   
    1355                                                                  


<210>  4
<211>  1355
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  4

Met Arg Leu Leu Ala Leu Val Leu Leu Leu Leu Cys Ala Pro Leu Arg 
1               5                   10                  15      


Ala Trp Thr Tyr Ser Leu Arg Tyr Gly Ile Pro Glu Ser Ala Gln Val 
            20                  25                  30          


Trp Ser Ile Leu Val His Leu Leu Gly Asp Val Asp Asn Gln Leu Leu 
        35                  40                  45              


Thr Asn Leu Tyr Pro Leu Val Thr Gly Leu Asp Asp Glu Ile Asp Ile 
    50                  55                  60                  


Gln Glu Asn Leu Val Thr Ser Asn Val Leu Arg Glu Arg Tyr Asp Lys 
65                  70                  75                  80  


Glu Asp Val Ala Asp Leu Leu Glu Leu Tyr Ala Ser Leu Tyr Pro Met 
                85                  90                  95      


Gly Met Ile Gln His Asp Ile Ser Ser Asn Ala Glu Gln Asp Asp Ala 
            100                 105                 110         


Asn Ser Ser Tyr Phe Val Leu Asn Gly Asn Arg Tyr Glu Lys Pro Asp 
        115                 120                 125             


Asp Val Phe Tyr Leu Lys Ser Lys Asp Leu Thr Ile Gln Gln Lys Val 
    130                 135                 140                 


Pro Asp Val Asp Val Ile Gln Pro Tyr Asp Val Val Ile Gly Thr Asn 
145                 150                 155                 160 


Ser Glu Ala Pro Ile Leu Ile Leu Tyr Gly Cys Pro Thr Val Ile Asp 
                165                 170                 175     


Ser Asp Phe Glu Glu Phe Asn Arg Asn Leu Phe Met Glu Ala Met Asn 
            180                 185                 190         


Gly Glu Gly Lys Phe Arg Phe Ile Trp Arg Ser Thr Cys Ser Leu Asp 
        195                 200                 205             


Gly Lys Ser Val Glu Tyr Pro Leu Thr His Pro Leu Glu Ile Thr Leu 
    210                 215                 220                 


Gln Asn Gly Ser Arg Met Ser Ser Ile Pro Gln Leu Lys Lys Ile Leu 
225                 230                 235                 240 


Tyr Thr Val Pro Lys Glu Ile Leu Val Gly Ala Asp Asn Asp Asp Gln 
                245                 250                 255     


Leu His Asp Leu Glu Pro Glu Glu Leu Arg Glu Leu Asp Leu Arg Val 
            260                 265                 270         


Thr Ser Leu Ile Ser Glu Phe Tyr Gln Tyr Lys Lys Asp Ile Thr Ala 
        275                 280                 285             


Thr Leu Asn Phe Thr Lys Ser Ile Val Asn Asn Phe Pro Leu Ile Ser 
    290                 295                 300                 


Lys Gln Leu Ile Lys Val Ser Ser Val Asn Lys Asp Ile Ile Thr Ser 
305                 310                 315                 320 


Asn Glu Glu Leu Asn Ser Lys Gly Phe Asp Tyr Asn Met Leu Gly Ile 
                325                 330                 335     


Asn Gly Gln Asn Trp Lys Ile Thr Ser Leu Thr Pro Tyr Asn Leu Leu 
            340                 345                 350         


Thr Ala Leu Lys Thr Glu Tyr Gln Ser Leu Leu Lys Ile Thr Asn Leu 
        355                 360                 365             


Leu Gln Glu Leu Glu Pro Ser Lys Cys Ile Leu Asp Ser Lys Phe Leu 
    370                 375                 380                 


Leu Asn Lys Phe Ser Gln Phe Ser Leu Gly Lys Leu Gln Asn Leu Gln 
385                 390                 395                 400 


Pro Ile Lys Met Asp Leu His Thr Ile Pro Gly Phe Ser Glu Ser Val 
                405                 410                 415     


Ile Tyr Phe Asn Asp Ile Glu Ser Asp Pro Gln Tyr Asp Glu Leu Val 
            420                 425                 430         


Asn Ser Val Gln Ala Phe Phe Asp Lys Ser Lys Phe Gly Glu Leu Pro 
        435                 440                 445             


Glu Ile Lys Gln Asn Trp Ser Glu Ile Ile Phe Val Ile Asp Phe Ala 
    450                 455                 460                 


Arg Leu Glu Asp Ser Glu Val Lys Glu Ala Leu Gly Gly Leu Val Arg 
465                 470                 475                 480 


Ala Val Asn Val Val Ser Gln Gly Tyr Pro Gln Arg Val Gly Leu Leu 
                485                 490                 495     


Pro Phe Ser Ser Asp Ser Asp Lys Ser Val Val Asn Lys Ile Tyr Glu 
            500                 505                 510         


Leu Lys Asn Ser Thr Asp Asn Leu Thr Glu Leu Lys Ser Phe Leu Glu 
        515                 520                 525             


Thr Met Leu Leu Ala Asp Gly Leu Ser Ala Asn Ala Lys His Ser Lys 
    530                 535                 540                 


His Ile Pro Val Pro Asp Val Phe His Leu Leu Asp Glu Leu Gln Ile 
545                 550                 555                 560 


Asp Glu Thr Ser Ile Ile Ile Asn Gly Glu Ile Tyr Pro Phe Arg Lys 
                565                 570                 575     


Asn Trp Asn Tyr Leu Ile Ala Lys Val Ile Lys Lys Asp Thr Glu Phe 
            580                 585                 590         


Ile Arg Lys Glu Leu Ser Asn Ser Ser Pro Lys Asn Lys Gln Ile Ser 
        595                 600                 605             


Val Arg Asp Leu Leu His Tyr Lys Ser Ala Asn Leu Arg His Asn Lys 
    610                 615                 620                 


Tyr Thr Pro Asn Tyr Phe Ala Asp Ser Val Tyr Ser Ser Val Asn Asn 
625                 630                 635                 640 


Thr Ala Leu Glu Ser Val Cys Ser Ile Gly Tyr Tyr Thr Lys Asn Glu 
                645                 650                 655     


Glu Tyr Asn Leu Leu His Thr Ile Thr Leu Val Asp Asp Phe Gly Ser 
            660                 665                 670         


Ile His Ala Leu Lys Arg Leu Arg Asn Leu Leu His Thr Ser Phe Val 
        675                 680                 685             


Gly Val Arg Ile Arg Ile Ile His Val Gly Asp Ile Ser Asp Ile Trp 
    690                 695                 700                 


Tyr Gln Leu Arg Gly Ser Leu Ser Gln Lys Asp Pro Ile Gly Ser Ile 
705                 710                 715                 720 


Asn Thr Phe Ile Asp Ala Leu Lys Leu Lys Lys Val Lys Ser His Thr 
                725                 730                 735     


Tyr Lys Lys Ser Gln Gln Leu Gly Leu His Lys Trp Leu Pro Asp Ile 
            740                 745                 750         


Pro Leu Phe Glu Leu Gln Lys Gly Ser Phe Ile Ala Leu Asn Gly Arg 
        755                 760                 765             


Phe Ile Ile Leu Ile Lys Met Lys Cys Gln Lys Gln Asn Ile Ser Lys 
    770                 775                 780                 


Ala Lys Ile Ile Lys Arg Glu Ala Leu Arg Thr Ile Asp Ser Val Phe 
785                 790                 795                 800 


Ala Leu Asp Leu Leu Phe Pro Gly Phe Ser Gln Glu Ile Ile Asn Pro 
                805                 810                 815     


Asp Leu Ile Glu Met Ile Ser Ser Ile Leu Thr Arg Leu Phe Tyr Gln 
            820                 825                 830         


Gly Thr His Ile Tyr Asn Asn Gly Ile Asp Tyr Thr Thr Glu Ser Ser 
        835                 840                 845             


Leu Pro Arg Met Asp Leu Ser Glu Phe Phe Arg Pro Asn Asn Leu Thr 
    850                 855                 860                 


Met Phe Glu Asp Gly Lys Ser Ala Ser Ile Asp Leu Leu Leu Ile Leu 
865                 870                 875                 880 


Asp Pro Leu Glu Glu Arg Thr Gln Met Ile Leu Ser Leu Val Glu Gln 
                885                 890                 895     


Phe Arg Pro Leu Lys Phe Val Asn Ile Gln Val Ile Leu Met Pro Thr 
            900                 905                 910         


Leu Glu Leu Asn Ile Val Pro Ile Arg Arg Ile Tyr Val Asp Asp Ala 
        915                 920                 925             


Asp Ile Val Lys Ser Ile Thr Ser Glu Asp Ser Arg Ser Asp Pro Glu 
    930                 935                 940                 


Val Asp Ile Glu Met Asp Val Pro Asn Ser Phe Ile Val Asp Asn Asn 
945                 950                 955                 960 


Tyr Arg Ile Lys Lys Leu Leu Ile Glu Leu His Ser Phe Ser Ser Lys 
                965                 970                 975     


Thr Val Leu Ser Thr Gly Asn Ile Asp Gly Met Gly Gly Val Cys Leu 
            980                 985                 990         


Ala Leu Val Asp Ser Ala Gly Asn  Ile Ile Asp Lys Thr  Thr Thr Met 
        995                 1000                 1005             


Lys Thr  Phe Gly Tyr Gly Gln  Phe His Thr Asp Lys  Phe Leu Lys 
    1010                 1015                 1020             


Gly Cys  Tyr Ile Lys Ser Cys  Asp Ser Arg Tyr Thr  Val Gln Ser 
    1025                 1030                 1035             


Phe Ser  Thr Asp Gly His Pro  Asp Phe Ile Pro Ser  Asp Ser Leu 
    1040                 1045                 1050             


Asp Ile  Leu Ser Tyr Asn Pro  Gln Lys Ile Ala Val  Lys Ile Ser 
    1055                 1060                 1065             


Glu Glu  Pro Thr His Glu Glu  Glu Tyr Glu Glu Gly  Arg Asn Asn 
    1070                 1075                 1080             


Asp Thr  Ile Ile Asn Ile Phe  Thr Ile Ser Gly Pro  Asp Glu Glu 
    1085                 1090                 1095             


Glu Arg  Tyr Met Gln Met Ile  Leu Ser Ile Leu Ser  Lys Cys Pro 
    1100                 1105                 1110             


Glu Thr  Gln Lys Val Asn Phe  Phe Ile Leu Asp Gln  Pro Phe Ile 
    1115                 1120                 1125             


Ser Asp  Thr Leu Arg Lys Ser  Cys Glu Tyr Ile Asn  Ser Ser Asp 
    1130                 1135                 1140             


Glu Met  Arg Gly Asn Val Ile  Phe Leu Asn Tyr Glu  Trp Pro Gln 
    1145                 1150                 1155             


Trp Leu  Arg Pro Gln Arg Phe  Ser Ser Arg Arg Arg  Asp Val Ser 
    1160                 1165                 1170             


Arg Phe  Leu Phe Leu Asp Val  Leu Leu Pro Gln Asn  Ile Ser Lys 
    1175                 1180                 1185             


Val Leu  Tyr Met Ser Pro Thr  Glu Val Pro Leu Asp  Pro Phe Asp 
    1190                 1195                 1200             


Ile Phe  Gln Phe Gln Gly Leu  Lys Arg Ala Pro Leu  Gly Leu Phe 
    1205                 1210                 1215             


Arg Met  Ser Gly Asp Gly Tyr  Trp Lys Glu Gly Tyr  Trp Glu Lys 
    1220                 1225                 1230             


Met Leu  Arg Glu Asn Asn Leu  Glu Phe Tyr Ser Thr  Glu Pro Ala 
    1235                 1240                 1245             


Phe Leu  Val Asn Leu Glu Arg  Phe Arg Glu Leu Asp  Ala Gly Asp 
    1250                 1255                 1260             


Lys Tyr  Arg Ile His Tyr Gln  Arg Ile Ser Thr Asp  Ala Met Ser 
    1265                 1270                 1275             


Leu Val  Asn Ile Gly Gln Asp  Leu Val Asn Asn Leu  Gln Leu Glu 
    1280                 1285                 1290             


Val Pro  Ile Arg Phe Leu Lys  Gly Ser Tyr Lys Lys  Lys Leu Val 
    1295                 1300                 1305             


Ile Asn  Asp Glu Cys Val Ser  Glu Trp Lys Lys Lys  Ile Asn Lys 
    1310                 1315                 1320             


Phe Ala  Ser Ser Pro Gly Asp  Glu Asp Val Pro Gly  Glu Ser Val 
    1325                 1330                 1335             


Ser Ser  Lys Tyr Gln Asp Ser  Asp Asn Ala Ala Pro  Leu His Asp 
    1340                 1345                 1350             


Glu Leu  
    1355 


<210>  5
<211>  5616
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  CDS
<222>  (1)..(5616)
<223>  Saccharomyces cerevisiae s288c FKS1 (codon optimized)

<400>  5
atg aat acc gac cag caa ccg tac caa gga cag acc gac tat acc caa         48
Met Asn Thr Asp Gln Gln Pro Tyr Gln Gly Gln Thr Asp Tyr Thr Gln           
1               5                   10                  15                

ggc cca gga aac gga cag agc caa gag caa gac tac gat caa tac ggg         96
Gly Pro Gly Asn Gly Gln Ser Gln Glu Gln Asp Tyr Asp Gln Tyr Gly           
            20                  25                  30                    

cag ccg ctg tat ccg agt caa gcg gat ggc tac tac gac ccg aac gtt        144
Gln Pro Leu Tyr Pro Ser Gln Ala Asp Gly Tyr Tyr Asp Pro Asn Val           
        35                  40                  45                        

gcc gca ggc acg gaa gcc gac atg tat ggc cag cag ccc ccg aac gag        192
Ala Ala Gly Thr Glu Ala Asp Met Tyr Gly Gln Gln Pro Pro Asn Glu           
    50                  55                  60                            

tcg tat gac cag gat tat acc aac ggc gag tat tat ggc cag ccg ccc        240
Ser Tyr Asp Gln Asp Tyr Thr Asn Gly Glu Tyr Tyr Gly Gln Pro Pro           
65                  70                  75                  80            

aac atg gcc gct caa gac ggc gag aat ttc agc gac ttc tcc tcg tat        288
Asn Met Ala Ala Gln Asp Gly Glu Asn Phe Ser Asp Phe Ser Ser Tyr           
                85                  90                  95                

ggt ccg cct ggt acc ccg ggg tac gat tcc tat ggc ggg cag tac acg        336
Gly Pro Pro Gly Thr Pro Gly Tyr Asp Ser Tyr Gly Gly Gln Tyr Thr           
            100                 105                 110                   

gca tcg caa atg tcc tat ggc gag ccg aat agc tcg ggc acc agt acg        384
Ala Ser Gln Met Ser Tyr Gly Glu Pro Asn Ser Ser Gly Thr Ser Thr           
        115                 120                 125                       

ccg ata tac ggc aac tac gat ccg aac gcc atc gca atg gca ctg ccc        432
Pro Ile Tyr Gly Asn Tyr Asp Pro Asn Ala Ile Ala Met Ala Leu Pro           
    130                 135                 140                           

aac gag ccg tac ccc gcg tgg acg gcc gac tcg cag agc ccg gtc agc        480
Asn Glu Pro Tyr Pro Ala Trp Thr Ala Asp Ser Gln Ser Pro Val Ser           
145                 150                 155                 160           

atc gaa cag atc gag gac ata ttc atc gac ctc acc aat cgc ctc ggc        528
Ile Glu Gln Ile Glu Asp Ile Phe Ile Asp Leu Thr Asn Arg Leu Gly           
                165                 170                 175               

ttc cag cgc gac tcc atg cgc aac atg ttc gac cat ttc atg gtc ctc        576
Phe Gln Arg Asp Ser Met Arg Asn Met Phe Asp His Phe Met Val Leu           
            180                 185                 190                   

ctc gac tcc cgc tcc tcg cgc atg agc ccg gac caa gcg ctc ctg tcc        624
Leu Asp Ser Arg Ser Ser Arg Met Ser Pro Asp Gln Ala Leu Leu Ser           
        195                 200                 205                       

ttg cat gct gac tat att ggc ggc gac acc gcc aac tat aag aaa tgg        672
Leu His Ala Asp Tyr Ile Gly Gly Asp Thr Ala Asn Tyr Lys Lys Trp           
    210                 215                 220                           

tat ttc gcc gcc cag ctc gac atg gac gac gag att ggc ttc cgg aat        720
Tyr Phe Ala Ala Gln Leu Asp Met Asp Asp Glu Ile Gly Phe Arg Asn           
225                 230                 235                 240           

atg tcc ctc ggg aag ctc tcg cgc aag gcc cgc aag gca aag aaa aag        768
Met Ser Leu Gly Lys Leu Ser Arg Lys Ala Arg Lys Ala Lys Lys Lys           
                245                 250                 255               

aac aag aag gca atg gaa gag gcg aat ccc gag gat acc gag gaa acc        816
Asn Lys Lys Ala Met Glu Glu Ala Asn Pro Glu Asp Thr Glu Glu Thr           
            260                 265                 270                   

ctc aat aag att gag ggc gac aac agc ctt gag gct gcg gac ttc cgc        864
Leu Asn Lys Ile Glu Gly Asp Asn Ser Leu Glu Ala Ala Asp Phe Arg           
        275                 280                 285                       

tgg aaa gcg aag atg aat cag ctg tcg ccc ctt gag cgc gtc cgc cac        912
Trp Lys Ala Lys Met Asn Gln Leu Ser Pro Leu Glu Arg Val Arg His           
    290                 295                 300                           

atc gcg ctc tat ctc ctg tgt tgg ggg gaa gcc aat cag gtc cgc ttc        960
Ile Ala Leu Tyr Leu Leu Cys Trp Gly Glu Ala Asn Gln Val Arg Phe           
305                 310                 315                 320           

acc gcc gaa tgc ctc tgc ttc atc tac aag tgc gcg ctc gat tac ctg       1008
Thr Ala Glu Cys Leu Cys Phe Ile Tyr Lys Cys Ala Leu Asp Tyr Leu           
                325                 330                 335               

gac agc ccg ctc tgc cag cag cgg caa gaa ccc atg ccc gag ggt gac       1056
Asp Ser Pro Leu Cys Gln Gln Arg Gln Glu Pro Met Pro Glu Gly Asp           
            340                 345                 350                   

ttc ctg aat cgc gtg atc acc ccg atc tat cac ttc ata cgc aac cag       1104
Phe Leu Asn Arg Val Ile Thr Pro Ile Tyr His Phe Ile Arg Asn Gln           
        355                 360                 365                       

gtg tac gag att gtg gat ggc cgg ttc gtc aag cgc gag cgc gat cac       1152
Val Tyr Glu Ile Val Asp Gly Arg Phe Val Lys Arg Glu Arg Asp His           
    370                 375                 380                           

aat aag atc gtg ggc tat gat gac ctg aac cag ctc ttt tgg tac ccg       1200
Asn Lys Ile Val Gly Tyr Asp Asp Leu Asn Gln Leu Phe Trp Tyr Pro           
385                 390                 395                 400           

gaa gga atc gcg aag ata gtt ctg gaa gat ggc acc aag ctt atc gag       1248
Glu Gly Ile Ala Lys Ile Val Leu Glu Asp Gly Thr Lys Leu Ile Glu           
                405                 410                 415               

ctc ccg ctt gag gag cgc tat ctg cgg ctg ggt gac gtc gtg tgg gac       1296
Leu Pro Leu Glu Glu Arg Tyr Leu Arg Leu Gly Asp Val Val Trp Asp           
            420                 425                 430                   

gac gtg ttc ttc aaa acg tac aag gaa acg cgc acc tgg ctg cac ctt       1344
Asp Val Phe Phe Lys Thr Tyr Lys Glu Thr Arg Thr Trp Leu His Leu           
        435                 440                 445                       

gtc acg aac ttc aat cgc atc tgg gtg atg cat atc tcg att ttc tgg       1392
Val Thr Asn Phe Asn Arg Ile Trp Val Met His Ile Ser Ile Phe Trp           
    450                 455                 460                           

atg tac ttc gca tac aac tcg ccg acg ttc tat acc cac aat tat cag       1440
Met Tyr Phe Ala Tyr Asn Ser Pro Thr Phe Tyr Thr His Asn Tyr Gln           
465                 470                 475                 480           

caa ctc gtc gac aat caa ccg ctg gcc gcg tac aag tgg gcg tcg tgc       1488
Gln Leu Val Asp Asn Gln Pro Leu Ala Ala Tyr Lys Trp Ala Ser Cys           
                485                 490                 495               

gct ctg ggc ggc acc gtg gcg tcc ctc atc cag att gtc gcc acg ctc       1536
Ala Leu Gly Gly Thr Val Ala Ser Leu Ile Gln Ile Val Ala Thr Leu           
            500                 505                 510                   

tgt gag tgg tcc ttc gtc ccg cgg aaa tgg gcg gga gcc cag cat ctg       1584
Cys Glu Trp Ser Phe Val Pro Arg Lys Trp Ala Gly Ala Gln His Leu           
        515                 520                 525                       

tcg cgc cgg ttc tgg ttc ctg tgc atc atc ttc ggg atc aac ctg ggc       1632
Ser Arg Arg Phe Trp Phe Leu Cys Ile Ile Phe Gly Ile Asn Leu Gly           
    530                 535                 540                           

ccg atc atc ttc gtg ttc gcc tac gac aag gac acg gtc tat tcc acc       1680
Pro Ile Ile Phe Val Phe Ala Tyr Asp Lys Asp Thr Val Tyr Ser Thr           
545                 550                 555                 560           

gca gcg cat gtc gtc gca gcg gtc atg ttc ttc gtt gcg gtc gcg acc       1728
Ala Ala His Val Val Ala Ala Val Met Phe Phe Val Ala Val Ala Thr           
                565                 570                 575               

atc atc ttt ttc tcc atc atg cca ctg ggt ggc ctc ttc acc agc tat       1776
Ile Ile Phe Phe Ser Ile Met Pro Leu Gly Gly Leu Phe Thr Ser Tyr           
            580                 585                 590                   

atg aag aaa tcg act cgc cgg tac gtc gct agc cag acc ttc acg gca       1824
Met Lys Lys Ser Thr Arg Arg Tyr Val Ala Ser Gln Thr Phe Thr Ala           
        595                 600                 605                       

gcg ttc gca ccc ctg cat ggc ctc gac cgc tgg atg agc tac ttg gtg       1872
Ala Phe Ala Pro Leu His Gly Leu Asp Arg Trp Met Ser Tyr Leu Val           
    610                 615                 620                           

tgg gtc acg gtg ttc gcg gcc aag tat tcc gag tcc tac tat ttc ctc       1920
Trp Val Thr Val Phe Ala Ala Lys Tyr Ser Glu Ser Tyr Tyr Phe Leu           
625                 630                 635                 640           

gtg ctg tcc ctc cgc gac ccg atc cgc atc ctg agc acc acc gcc atg       1968
Val Leu Ser Leu Arg Asp Pro Ile Arg Ile Leu Ser Thr Thr Ala Met           
                645                 650                 655               

cgc tgc acc ggg gag tac tgg tgg ggt gcg gtg ctc tgc aaa gtc cag       2016
Arg Cys Thr Gly Glu Tyr Trp Trp Gly Ala Val Leu Cys Lys Val Gln           
            660                 665                 670                   

ccc aag atc gtt ctt ggc ctg gtg atc gcg acg gac ttc atc ctc ttt       2064
Pro Lys Ile Val Leu Gly Leu Val Ile Ala Thr Asp Phe Ile Leu Phe           
        675                 680                 685                       

ttc ctt gac acc tat ctg tgg tac att atc gtc aac acc att ttc agc       2112
Phe Leu Asp Thr Tyr Leu Trp Tyr Ile Ile Val Asn Thr Ile Phe Ser           
    690                 695                 700                           

gtg ggc aag tcg ttc tac ctc ggc atc agt atc ctg acc ccg tgg cgc       2160
Val Gly Lys Ser Phe Tyr Leu Gly Ile Ser Ile Leu Thr Pro Trp Arg           
705                 710                 715                 720           

aac atc ttc acc cgg ctc ccc aag cgc ata tac tcg aag att ctg gcc       2208
Asn Ile Phe Thr Arg Leu Pro Lys Arg Ile Tyr Ser Lys Ile Leu Ala           
                725                 730                 735               

acc act gac atg gag atc aag tat aag ccg aag gtc ctc att agc cag       2256
Thr Thr Asp Met Glu Ile Lys Tyr Lys Pro Lys Val Leu Ile Ser Gln           
            740                 745                 750                   

gtg tgg aac gcg atc ata atc tcg atg tat cgg gag cac ttg ctg gct       2304
Val Trp Asn Ala Ile Ile Ile Ser Met Tyr Arg Glu His Leu Leu Ala           
        755                 760                 765                       

atc gac cac gtg cag aaa ctg ctg tat cat caa gtg ccc agt gag atc       2352
Ile Asp His Val Gln Lys Leu Leu Tyr His Gln Val Pro Ser Glu Ile           
    770                 775                 780                           

gag ggt aaa cgg acg ctg agg gca ccc acc ttc ttt gtg agc cag gat       2400
Glu Gly Lys Arg Thr Leu Arg Ala Pro Thr Phe Phe Val Ser Gln Asp           
785                 790                 795                 800           

gac aat aat ttt gaa acc gaa ttc ttc cct cgc gat tcc gag gcc gag       2448
Asp Asn Asn Phe Glu Thr Glu Phe Phe Pro Arg Asp Ser Glu Ala Glu           
                805                 810                 815               

cgg cgc atc agc ttc ttt gcc caa tcc ctg tcg acg ccc atc ccg gag       2496
Arg Arg Ile Ser Phe Phe Ala Gln Ser Leu Ser Thr Pro Ile Pro Glu           
            820                 825                 830                   

ccc ctg ccg gtg gac aac atg ccg acc ttt acc gtg ctc acg ccc cat       2544
Pro Leu Pro Val Asp Asn Met Pro Thr Phe Thr Val Leu Thr Pro His           
        835                 840                 845                       

tat gcc gag cgc atc ctc ctg agc ttg cgc gag atc atc cgc gag gac       2592
Tyr Ala Glu Arg Ile Leu Leu Ser Leu Arg Glu Ile Ile Arg Glu Asp           
    850                 855                 860                           

gac cag ttc tcg cgg gtt acg ctc ctg gag tac ctc aag caa ctg cat       2640
Asp Gln Phe Ser Arg Val Thr Leu Leu Glu Tyr Leu Lys Gln Leu His           
865                 870                 875                 880           

ccg gtg gag tgg gag tgc ttc gtc aaa gac acc aaa atc ctg gcc gag       2688
Pro Val Glu Trp Glu Cys Phe Val Lys Asp Thr Lys Ile Leu Ala Glu           
                885                 890                 895               

gaa act gct gcg tac gag ggc aat gag aac gag gcc gag aag gaa gat       2736
Glu Thr Ala Ala Tyr Glu Gly Asn Glu Asn Glu Ala Glu Lys Glu Asp           
            900                 905                 910                   

gca ctg aaa tcc cag atc gac gat ttg cct ttc tat tgt atc ggc ttc       2784
Ala Leu Lys Ser Gln Ile Asp Asp Leu Pro Phe Tyr Cys Ile Gly Phe           
        915                 920                 925                       

aag agt gcg gcc ccg gag tac acg ctc cgc acc cgg atc tgg gcg agt       2832
Lys Ser Ala Ala Pro Glu Tyr Thr Leu Arg Thr Arg Ile Trp Ala Ser           
    930                 935                 940                           

ctg cgc tcc cag acc ctc tac cgc acc atc tcg ggc ttc atg aac tat       2880
Leu Arg Ser Gln Thr Leu Tyr Arg Thr Ile Ser Gly Phe Met Asn Tyr           
945                 950                 955                 960           

tcg cgc gct atc aag ctg ctt tat cgg gtc gag aac ccc gag atc gtg       2928
Ser Arg Ala Ile Lys Leu Leu Tyr Arg Val Glu Asn Pro Glu Ile Val           
                965                 970                 975               

caa atg ttc ggt ggc aat gcc gag ggc ctt gag cgc gag ctg gag aaa       2976
Gln Met Phe Gly Gly Asn Ala Glu Gly Leu Glu Arg Glu Leu Glu Lys           
            980                 985                 990                   

atg gcg agg cgc aag ttc aag ttc  ctg gtg tcc atg cag  cgg ctg gcg     3024
Met Ala Arg Arg Lys Phe Lys Phe  Leu Val Ser Met Gln  Arg Leu Ala         
        995                 1000                 1005                     

aag ttt  aag ttc ctc gaa aat  gcc gag ttc ctc ctc  cgg gcg tac        3069
Lys Phe  Lys Phe Leu Glu Asn  Ala Glu Phe Leu Leu  Arg Ala Tyr            
    1010                 1015                 1020                        

ccg gac  ctc cag atc gcc tat  ctt gac gag gaa ccc  ccg ctg acg        3114
Pro Asp  Leu Gln Ile Ala Tyr  Leu Asp Glu Glu Pro  Pro Leu Thr            
    1025                 1030                 1035                        

gag ggc  gag gag ccg cgg atc  tat tcg gcg ctc att  gac ggc cac        3159
Glu Gly  Glu Glu Pro Arg Ile  Tyr Ser Ala Leu Ile  Asp Gly His            
    1040                 1045                 1050                        

tgc gag  atc ctc gac aac ggt  cgg cgc agg cca aag  ttc cgc gtg        3204
Cys Glu  Ile Leu Asp Asn Gly  Arg Arg Arg Pro Lys  Phe Arg Val            
    1055                 1060                 1065                        

caa ctc  agc ggc aat ccc att  ctg ggc gac ggc aaa  tcc gac aac        3249
Gln Leu  Ser Gly Asn Pro Ile  Leu Gly Asp Gly Lys  Ser Asp Asn            
    1070                 1075                 1080                        

caa aac  cat gcc ctg atc ttc  tat agg ggt gag tat  att cag ctg        3294
Gln Asn  His Ala Leu Ile Phe  Tyr Arg Gly Glu Tyr  Ile Gln Leu            
    1085                 1090                 1095                        

atc gac  gcg aac cag gac aat  tat ctt gag gaa tgc  ctc aag atc        3339
Ile Asp  Ala Asn Gln Asp Asn  Tyr Leu Glu Glu Cys  Leu Lys Ile            
    1100                 1105                 1110                        

cgc tcg  gtc ctg gcc gag ttc  gag gag ctc aac gtc  gaa cag gtc        3384
Arg Ser  Val Leu Ala Glu Phe  Glu Glu Leu Asn Val  Glu Gln Val            
    1115                 1120                 1125                        

aac cct  tat gct ccg ggc ctg  cgg tac gaa gaa cag  acc acg aac        3429
Asn Pro  Tyr Ala Pro Gly Leu  Arg Tyr Glu Glu Gln  Thr Thr Asn            
    1130                 1135                 1140                        

cat ccg  gtc gcc atc gtc gga  gcg cgc gag tac att  ttc tcg gag        3474
His Pro  Val Ala Ile Val Gly  Ala Arg Glu Tyr Ile  Phe Ser Glu            
    1145                 1150                 1155                        

aat tcc  ggc gtc ctc ggc gat  gtg gcg gca ggc aag  gag cag acc        3519
Asn Ser  Gly Val Leu Gly Asp  Val Ala Ala Gly Lys  Glu Gln Thr            
    1160                 1165                 1170                        

ttc ggc  acc ctg ttc gcc cgc  acc ctc tcc cag att  ggt ggc aaa        3564
Phe Gly  Thr Leu Phe Ala Arg  Thr Leu Ser Gln Ile  Gly Gly Lys            
    1175                 1180                 1185                        

ctg cat  tac ggc cat ccg gac  ttc ata aac gcg acc  ttc atg acc        3609
Leu His  Tyr Gly His Pro Asp  Phe Ile Asn Ala Thr  Phe Met Thr            
    1190                 1195                 1200                        

acc cgg  ggt ggc gtc agc aag  gcc caa aag ggc ctc  cat ctt aac        3654
Thr Arg  Gly Gly Val Ser Lys  Ala Gln Lys Gly Leu  His Leu Asn            
    1205                 1210                 1215                        

gaa gat  atc tac gcg ggt atg  aat gcc atg ctc agg  ggc ggt cgg        3699
Glu Asp  Ile Tyr Ala Gly Met  Asn Ala Met Leu Arg  Gly Gly Arg            
    1220                 1225                 1230                        

atc aag  cat tgt gag tat tac  cag tgc gga aag ggc  agg gat ctg        3744
Ile Lys  His Cys Glu Tyr Tyr  Gln Cys Gly Lys Gly  Arg Asp Leu            
    1235                 1240                 1245                        

ggc ttc  ggc acc atc ctc aat  ttc acc acc aag atc  ggg gca ggc        3789
Gly Phe  Gly Thr Ile Leu Asn  Phe Thr Thr Lys Ile  Gly Ala Gly            
    1250                 1255                 1260                        

atg gga  gaa cag atg ttg agc  cgg gag tac tat tac  ctc ggg acg        3834
Met Gly  Glu Gln Met Leu Ser  Arg Glu Tyr Tyr Tyr  Leu Gly Thr            
    1265                 1270                 1275                        

cag ctc  ccg gtc gat cgg ttc  ctg acc ttc tac tat  gcc cat ccg        3879
Gln Leu  Pro Val Asp Arg Phe  Leu Thr Phe Tyr Tyr  Ala His Pro            
    1280                 1285                 1290                        

ggt ttc  cat ctg aat aac ctc  ttc atc caa ctg tcc  ctt cag atg        3924
Gly Phe  His Leu Asn Asn Leu  Phe Ile Gln Leu Ser  Leu Gln Met            
    1295                 1300                 1305                        

ttc atg  ttg acg ctc gtg aac  ctg agt agc ctc gca  cat gag tcg        3969
Phe Met  Leu Thr Leu Val Asn  Leu Ser Ser Leu Ala  His Glu Ser            
    1310                 1315                 1320                        

atc atg  tgc atc tac gat cgg  aat aag ccg aaa acc  gac gtc ctg        4014
Ile Met  Cys Ile Tyr Asp Arg  Asn Lys Pro Lys Thr  Asp Val Leu            
    1325                 1330                 1335                        

gtg ccg  att ggc tgc tac aac  ttc cag ccc gcg gtc  gac tgg gtc        4059
Val Pro  Ile Gly Cys Tyr Asn  Phe Gln Pro Ala Val  Asp Trp Val            
    1340                 1345                 1350                        

cgc cgc  tat acg ctt agc atc  ttt atc gtg ttc tgg  atc gcg ttc        4104
Arg Arg  Tyr Thr Leu Ser Ile  Phe Ile Val Phe Trp  Ile Ala Phe            
    1355                 1360                 1365                        

gtg ccg  atc gtt gtg cag gag  ctg atc gag cgc ggt  ctg tgg aag        4149
Val Pro  Ile Val Val Gln Glu  Leu Ile Glu Arg Gly  Leu Trp Lys            
    1370                 1375                 1380                        

gcc acg  cag cgc ttc ttc tgc  cat ctg ctg tcg ctg  agt ccg atg        4194
Ala Thr  Gln Arg Phe Phe Cys  His Leu Leu Ser Leu  Ser Pro Met            
    1385                 1390                 1395                        

ttc gag  gtc ttt gcg ggc caa  atc tat tcg agc gcg  ctc ctg agc        4239
Phe Glu  Val Phe Ala Gly Gln  Ile Tyr Ser Ser Ala  Leu Leu Ser            
    1400                 1405                 1410                        

gat ttg  gcg atc ggg gga gcg  cgc tac atc tcg acg  ggt cgg ggc        4284
Asp Leu  Ala Ile Gly Gly Ala  Arg Tyr Ile Ser Thr  Gly Arg Gly            
    1415                 1420                 1425                        

ttc gcc  acc tcc cgc att cca  ttc agc atc aag cgc  ttc gcg ggc        4329
Phe Ala  Thr Ser Arg Ile Pro  Phe Ser Ile Lys Arg  Phe Ala Gly            
    1430                 1435                 1440                        

tcg gcg  atc tac atg ggc gca  cgc tcg atg ttg atg  ctg ctg ttc        4374
Ser Ala  Ile Tyr Met Gly Ala  Arg Ser Met Leu Met  Leu Leu Phe            
    1445                 1450                 1455                        

ggc acc  gtg gct cat tgg cag  gcg ccg ctc ctg tgg  ttc tgg gcg        4419
Gly Thr  Val Ala His Trp Gln  Ala Pro Leu Leu Trp  Phe Trp Ala            
    1460                 1465                 1470                        

tcc ctg  agc agc ctc atc ttc  gcc ccc ttc gtg ttc  aac ccg cat        4464
Ser Leu  Ser Ser Leu Ile Phe  Ala Pro Phe Val Phe  Asn Pro His            
    1475                 1480                 1485                        

cag ttt  gcg tgg gag gac ttt  ttc ctg gac tac cgc  gac tac atc        4509
Gln Phe  Ala Trp Glu Asp Phe  Phe Leu Asp Tyr Arg  Asp Tyr Ile            
    1490                 1495                 1500                        

cgg tgg  ctc tcc cgg gga aat  aac cag tac cac cgc  aat tcc tgg        4554
Arg Trp  Leu Ser Arg Gly Asn  Asn Gln Tyr His Arg  Asn Ser Trp            
    1505                 1510                 1515                        

att ggc  tat gtg cgg atg agc  cgc gct cgc atc acc  ggc ttc aag        4599
Ile Gly  Tyr Val Arg Met Ser  Arg Ala Arg Ile Thr  Gly Phe Lys            
    1520                 1525                 1530                        

cgg aaa  ctg gtc ggt gac gaa  agc gag aaa gcc gcg  ggc gac gcc        4644
Arg Lys  Leu Val Gly Asp Glu  Ser Glu Lys Ala Ala  Gly Asp Ala            
    1535                 1540                 1545                        

tcg cgg  gcc cac cgc acc aac  ctg atc atg gcc gag  atc atc ccc        4689
Ser Arg  Ala His Arg Thr Asn  Leu Ile Met Ala Glu  Ile Ile Pro            
    1550                 1555                 1560                        

tgc gcc  atc tat gcg gca ggg  tgc ttc ata gcg ttc  acc ttc atc        4734
Cys Ala  Ile Tyr Ala Ala Gly  Cys Phe Ile Ala Phe  Thr Phe Ile            
    1565                 1570                 1575                        

aac gcc  cag act ggc gtc aag  acc acc gac gac gac  cgg gtc aac        4779
Asn Ala  Gln Thr Gly Val Lys  Thr Thr Asp Asp Asp  Arg Val Asn            
    1580                 1585                 1590                        

tcg gtg  ctc cgc atc atc atc  tgc acg ctg gcg ccg  att gcg gtc        4824
Ser Val  Leu Arg Ile Ile Ile  Cys Thr Leu Ala Pro  Ile Ala Val            
    1595                 1600                 1605                        

aat ctc  ggg gtc ctc ttc ttc  tgc atg ggc atg tcg  tgc tgc tcc        4869
Asn Leu  Gly Val Leu Phe Phe  Cys Met Gly Met Ser  Cys Cys Ser            
    1610                 1615                 1620                        

ggc cca  ctg ttc ggc atg tgc  tgc aag aaa acg ggc  tcg gtc atg        4914
Gly Pro  Leu Phe Gly Met Cys  Cys Lys Lys Thr Gly  Ser Val Met            
    1625                 1630                 1635                        

gcc ggc  atc gcc cac ggc gtc  gcg gtc att gtg cat  atc gct ttc        4959
Ala Gly  Ile Ala His Gly Val  Ala Val Ile Val His  Ile Ala Phe            
    1640                 1645                 1650                        

ttc atc  gtg atg tgg gtt ctg  gag tcc ttc aat ttc  gtc cgg atg        5004
Phe Ile  Val Met Trp Val Leu  Glu Ser Phe Asn Phe  Val Arg Met            
    1655                 1660                 1665                        

ctg atc  ggc gtg gtg acg tgc  atc cag tgc cag cgc  ctc atc ttc        5049
Leu Ile  Gly Val Val Thr Cys  Ile Gln Cys Gln Arg  Leu Ile Phe            
    1670                 1675                 1680                        

cac tgc  atg acc gcc ctc atg  ctc acg cgg gag ttc  aaa aat gat        5094
His Cys  Met Thr Ala Leu Met  Leu Thr Arg Glu Phe  Lys Asn Asp            
    1685                 1690                 1695                        

cat gcg  aat acg gcc ttc tgg  acc ggc aaa tgg tac  ggc aag ggc        5139
His Ala  Asn Thr Ala Phe Trp  Thr Gly Lys Trp Tyr  Gly Lys Gly            
    1700                 1705                 1710                        

atg ggc  tat atg gcc tgg acg  caa ccc tcg cgc gag  ctg acg gcc        5184
Met Gly  Tyr Met Ala Trp Thr  Gln Pro Ser Arg Glu  Leu Thr Ala            
    1715                 1720                 1725                        

aag gtc  atc gag ttg tcc gag  ttt gcc gct gac ttc  gtc ctc ggc        5229
Lys Val  Ile Glu Leu Ser Glu  Phe Ala Ala Asp Phe  Val Leu Gly            
    1730                 1735                 1740                        

cat gtt  atc ttg atc tgc cag  ctg ccg ctg ata atc  ata ccg aag        5274
His Val  Ile Leu Ile Cys Gln  Leu Pro Leu Ile Ile  Ile Pro Lys            
    1745                 1750                 1755                        

atc gac  aag ttt cat tcc atc  atg ctg ttc tgg ctg  aaa ccg tcg        5319
Ile Asp  Lys Phe His Ser Ile  Met Leu Phe Trp Leu  Lys Pro Ser            
    1760                 1765                 1770                        

cgc cag  att agg ccc cct atc  tac tcg ctc aaa cag  act agg ctc        5364
Arg Gln  Ile Arg Pro Pro Ile  Tyr Ser Leu Lys Gln  Thr Arg Leu            
    1775                 1780                 1785                        

cgg aaa  cgc atg gtc aag aaa  tac tgc tcg ctg tat  ttc ctc gtg        5409
Arg Lys  Arg Met Val Lys Lys  Tyr Cys Ser Leu Tyr  Phe Leu Val            
    1790                 1795                 1800                        

ctg gcc  ata ttc gcg ggc tgc  atc atc gga ccg gcc  gtg gcg agc        5454
Leu Ala  Ile Phe Ala Gly Cys  Ile Ile Gly Pro Ala  Val Ala Ser            
    1805                 1810                 1815                        

gcc aag  atc cat aag cat atc  ggg gat tcc ctg gac  ggt gtc gtc        5499
Ala Lys  Ile His Lys His Ile  Gly Asp Ser Leu Asp  Gly Val Val            
    1820                 1825                 1830                        

cac aac  ctg ttc cag ccg atc  aac act acc aac aac  gac acc ggc        5544
His Asn  Leu Phe Gln Pro Ile  Asn Thr Thr Asn Asn  Asp Thr Gly            
    1835                 1840                 1845                        

tcc cag  atg tcg acc tac cag  tcg cac tac tac acc  cac acc ccg        5589
Ser Gln  Met Ser Thr Tyr Gln  Ser His Tyr Tyr Thr  His Thr Pro            
    1850                 1855                 1860                        

tcc ctt  aag acc tgg agc acc  ata aag                                 5616
Ser Leu  Lys Thr Trp Ser Thr  Ile Lys                                     
    1865                 1870                                             


<210>  6
<211>  1872
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  6

Met Asn Thr Asp Gln Gln Pro Tyr Gln Gly Gln Thr Asp Tyr Thr Gln 
1               5                   10                  15      


Gly Pro Gly Asn Gly Gln Ser Gln Glu Gln Asp Tyr Asp Gln Tyr Gly 
            20                  25                  30          


Gln Pro Leu Tyr Pro Ser Gln Ala Asp Gly Tyr Tyr Asp Pro Asn Val 
        35                  40                  45              


Ala Ala Gly Thr Glu Ala Asp Met Tyr Gly Gln Gln Pro Pro Asn Glu 
    50                  55                  60                  


Ser Tyr Asp Gln Asp Tyr Thr Asn Gly Glu Tyr Tyr Gly Gln Pro Pro 
65                  70                  75                  80  


Asn Met Ala Ala Gln Asp Gly Glu Asn Phe Ser Asp Phe Ser Ser Tyr 
                85                  90                  95      


Gly Pro Pro Gly Thr Pro Gly Tyr Asp Ser Tyr Gly Gly Gln Tyr Thr 
            100                 105                 110         


Ala Ser Gln Met Ser Tyr Gly Glu Pro Asn Ser Ser Gly Thr Ser Thr 
        115                 120                 125             


Pro Ile Tyr Gly Asn Tyr Asp Pro Asn Ala Ile Ala Met Ala Leu Pro 
    130                 135                 140                 


Asn Glu Pro Tyr Pro Ala Trp Thr Ala Asp Ser Gln Ser Pro Val Ser 
145                 150                 155                 160 


Ile Glu Gln Ile Glu Asp Ile Phe Ile Asp Leu Thr Asn Arg Leu Gly 
                165                 170                 175     


Phe Gln Arg Asp Ser Met Arg Asn Met Phe Asp His Phe Met Val Leu 
            180                 185                 190         


Leu Asp Ser Arg Ser Ser Arg Met Ser Pro Asp Gln Ala Leu Leu Ser 
        195                 200                 205             


Leu His Ala Asp Tyr Ile Gly Gly Asp Thr Ala Asn Tyr Lys Lys Trp 
    210                 215                 220                 


Tyr Phe Ala Ala Gln Leu Asp Met Asp Asp Glu Ile Gly Phe Arg Asn 
225                 230                 235                 240 


Met Ser Leu Gly Lys Leu Ser Arg Lys Ala Arg Lys Ala Lys Lys Lys 
                245                 250                 255     


Asn Lys Lys Ala Met Glu Glu Ala Asn Pro Glu Asp Thr Glu Glu Thr 
            260                 265                 270         


Leu Asn Lys Ile Glu Gly Asp Asn Ser Leu Glu Ala Ala Asp Phe Arg 
        275                 280                 285             


Trp Lys Ala Lys Met Asn Gln Leu Ser Pro Leu Glu Arg Val Arg His 
    290                 295                 300                 


Ile Ala Leu Tyr Leu Leu Cys Trp Gly Glu Ala Asn Gln Val Arg Phe 
305                 310                 315                 320 


Thr Ala Glu Cys Leu Cys Phe Ile Tyr Lys Cys Ala Leu Asp Tyr Leu 
                325                 330                 335     


Asp Ser Pro Leu Cys Gln Gln Arg Gln Glu Pro Met Pro Glu Gly Asp 
            340                 345                 350         


Phe Leu Asn Arg Val Ile Thr Pro Ile Tyr His Phe Ile Arg Asn Gln 
        355                 360                 365             


Val Tyr Glu Ile Val Asp Gly Arg Phe Val Lys Arg Glu Arg Asp His 
    370                 375                 380                 


Asn Lys Ile Val Gly Tyr Asp Asp Leu Asn Gln Leu Phe Trp Tyr Pro 
385                 390                 395                 400 


Glu Gly Ile Ala Lys Ile Val Leu Glu Asp Gly Thr Lys Leu Ile Glu 
                405                 410                 415     


Leu Pro Leu Glu Glu Arg Tyr Leu Arg Leu Gly Asp Val Val Trp Asp 
            420                 425                 430         


Asp Val Phe Phe Lys Thr Tyr Lys Glu Thr Arg Thr Trp Leu His Leu 
        435                 440                 445             


Val Thr Asn Phe Asn Arg Ile Trp Val Met His Ile Ser Ile Phe Trp 
    450                 455                 460                 


Met Tyr Phe Ala Tyr Asn Ser Pro Thr Phe Tyr Thr His Asn Tyr Gln 
465                 470                 475                 480 


Gln Leu Val Asp Asn Gln Pro Leu Ala Ala Tyr Lys Trp Ala Ser Cys 
                485                 490                 495     


Ala Leu Gly Gly Thr Val Ala Ser Leu Ile Gln Ile Val Ala Thr Leu 
            500                 505                 510         


Cys Glu Trp Ser Phe Val Pro Arg Lys Trp Ala Gly Ala Gln His Leu 
        515                 520                 525             


Ser Arg Arg Phe Trp Phe Leu Cys Ile Ile Phe Gly Ile Asn Leu Gly 
    530                 535                 540                 


Pro Ile Ile Phe Val Phe Ala Tyr Asp Lys Asp Thr Val Tyr Ser Thr 
545                 550                 555                 560 


Ala Ala His Val Val Ala Ala Val Met Phe Phe Val Ala Val Ala Thr 
                565                 570                 575     


Ile Ile Phe Phe Ser Ile Met Pro Leu Gly Gly Leu Phe Thr Ser Tyr 
            580                 585                 590         


Met Lys Lys Ser Thr Arg Arg Tyr Val Ala Ser Gln Thr Phe Thr Ala 
        595                 600                 605             


Ala Phe Ala Pro Leu His Gly Leu Asp Arg Trp Met Ser Tyr Leu Val 
    610                 615                 620                 


Trp Val Thr Val Phe Ala Ala Lys Tyr Ser Glu Ser Tyr Tyr Phe Leu 
625                 630                 635                 640 


Val Leu Ser Leu Arg Asp Pro Ile Arg Ile Leu Ser Thr Thr Ala Met 
                645                 650                 655     


Arg Cys Thr Gly Glu Tyr Trp Trp Gly Ala Val Leu Cys Lys Val Gln 
            660                 665                 670         


Pro Lys Ile Val Leu Gly Leu Val Ile Ala Thr Asp Phe Ile Leu Phe 
        675                 680                 685             


Phe Leu Asp Thr Tyr Leu Trp Tyr Ile Ile Val Asn Thr Ile Phe Ser 
    690                 695                 700                 


Val Gly Lys Ser Phe Tyr Leu Gly Ile Ser Ile Leu Thr Pro Trp Arg 
705                 710                 715                 720 


Asn Ile Phe Thr Arg Leu Pro Lys Arg Ile Tyr Ser Lys Ile Leu Ala 
                725                 730                 735     


Thr Thr Asp Met Glu Ile Lys Tyr Lys Pro Lys Val Leu Ile Ser Gln 
            740                 745                 750         


Val Trp Asn Ala Ile Ile Ile Ser Met Tyr Arg Glu His Leu Leu Ala 
        755                 760                 765             


Ile Asp His Val Gln Lys Leu Leu Tyr His Gln Val Pro Ser Glu Ile 
    770                 775                 780                 


Glu Gly Lys Arg Thr Leu Arg Ala Pro Thr Phe Phe Val Ser Gln Asp 
785                 790                 795                 800 


Asp Asn Asn Phe Glu Thr Glu Phe Phe Pro Arg Asp Ser Glu Ala Glu 
                805                 810                 815     


Arg Arg Ile Ser Phe Phe Ala Gln Ser Leu Ser Thr Pro Ile Pro Glu 
            820                 825                 830         


Pro Leu Pro Val Asp Asn Met Pro Thr Phe Thr Val Leu Thr Pro His 
        835                 840                 845             


Tyr Ala Glu Arg Ile Leu Leu Ser Leu Arg Glu Ile Ile Arg Glu Asp 
    850                 855                 860                 


Asp Gln Phe Ser Arg Val Thr Leu Leu Glu Tyr Leu Lys Gln Leu His 
865                 870                 875                 880 


Pro Val Glu Trp Glu Cys Phe Val Lys Asp Thr Lys Ile Leu Ala Glu 
                885                 890                 895     


Glu Thr Ala Ala Tyr Glu Gly Asn Glu Asn Glu Ala Glu Lys Glu Asp 
            900                 905                 910         


Ala Leu Lys Ser Gln Ile Asp Asp Leu Pro Phe Tyr Cys Ile Gly Phe 
        915                 920                 925             


Lys Ser Ala Ala Pro Glu Tyr Thr Leu Arg Thr Arg Ile Trp Ala Ser 
    930                 935                 940                 


Leu Arg Ser Gln Thr Leu Tyr Arg Thr Ile Ser Gly Phe Met Asn Tyr 
945                 950                 955                 960 


Ser Arg Ala Ile Lys Leu Leu Tyr Arg Val Glu Asn Pro Glu Ile Val 
                965                 970                 975     


Gln Met Phe Gly Gly Asn Ala Glu Gly Leu Glu Arg Glu Leu Glu Lys 
            980                 985                 990         


Met Ala Arg Arg Lys Phe Lys Phe  Leu Val Ser Met Gln  Arg Leu Ala 
        995                 1000                 1005             


Lys Phe  Lys Phe Leu Glu Asn  Ala Glu Phe Leu Leu  Arg Ala Tyr 
    1010                 1015                 1020             


Pro Asp  Leu Gln Ile Ala Tyr  Leu Asp Glu Glu Pro  Pro Leu Thr 
    1025                 1030                 1035             


Glu Gly  Glu Glu Pro Arg Ile  Tyr Ser Ala Leu Ile  Asp Gly His 
    1040                 1045                 1050             


Cys Glu  Ile Leu Asp Asn Gly  Arg Arg Arg Pro Lys  Phe Arg Val 
    1055                 1060                 1065             


Gln Leu  Ser Gly Asn Pro Ile  Leu Gly Asp Gly Lys  Ser Asp Asn 
    1070                 1075                 1080             


Gln Asn  His Ala Leu Ile Phe  Tyr Arg Gly Glu Tyr  Ile Gln Leu 
    1085                 1090                 1095             


Ile Asp  Ala Asn Gln Asp Asn  Tyr Leu Glu Glu Cys  Leu Lys Ile 
    1100                 1105                 1110             


Arg Ser  Val Leu Ala Glu Phe  Glu Glu Leu Asn Val  Glu Gln Val 
    1115                 1120                 1125             


Asn Pro  Tyr Ala Pro Gly Leu  Arg Tyr Glu Glu Gln  Thr Thr Asn 
    1130                 1135                 1140             


His Pro  Val Ala Ile Val Gly  Ala Arg Glu Tyr Ile  Phe Ser Glu 
    1145                 1150                 1155             


Asn Ser  Gly Val Leu Gly Asp  Val Ala Ala Gly Lys  Glu Gln Thr 
    1160                 1165                 1170             


Phe Gly  Thr Leu Phe Ala Arg  Thr Leu Ser Gln Ile  Gly Gly Lys 
    1175                 1180                 1185             


Leu His  Tyr Gly His Pro Asp  Phe Ile Asn Ala Thr  Phe Met Thr 
    1190                 1195                 1200             


Thr Arg  Gly Gly Val Ser Lys  Ala Gln Lys Gly Leu  His Leu Asn 
    1205                 1210                 1215             


Glu Asp  Ile Tyr Ala Gly Met  Asn Ala Met Leu Arg  Gly Gly Arg 
    1220                 1225                 1230             


Ile Lys  His Cys Glu Tyr Tyr  Gln Cys Gly Lys Gly  Arg Asp Leu 
    1235                 1240                 1245             


Gly Phe  Gly Thr Ile Leu Asn  Phe Thr Thr Lys Ile  Gly Ala Gly 
    1250                 1255                 1260             


Met Gly  Glu Gln Met Leu Ser  Arg Glu Tyr Tyr Tyr  Leu Gly Thr 
    1265                 1270                 1275             


Gln Leu  Pro Val Asp Arg Phe  Leu Thr Phe Tyr Tyr  Ala His Pro 
    1280                 1285                 1290             


Gly Phe  His Leu Asn Asn Leu  Phe Ile Gln Leu Ser  Leu Gln Met 
    1295                 1300                 1305             


Phe Met  Leu Thr Leu Val Asn  Leu Ser Ser Leu Ala  His Glu Ser 
    1310                 1315                 1320             


Ile Met  Cys Ile Tyr Asp Arg  Asn Lys Pro Lys Thr  Asp Val Leu 
    1325                 1330                 1335             


Val Pro  Ile Gly Cys Tyr Asn  Phe Gln Pro Ala Val  Asp Trp Val 
    1340                 1345                 1350             


Arg Arg  Tyr Thr Leu Ser Ile  Phe Ile Val Phe Trp  Ile Ala Phe 
    1355                 1360                 1365             


Val Pro  Ile Val Val Gln Glu  Leu Ile Glu Arg Gly  Leu Trp Lys 
    1370                 1375                 1380             


Ala Thr  Gln Arg Phe Phe Cys  His Leu Leu Ser Leu  Ser Pro Met 
    1385                 1390                 1395             


Phe Glu  Val Phe Ala Gly Gln  Ile Tyr Ser Ser Ala  Leu Leu Ser 
    1400                 1405                 1410             


Asp Leu  Ala Ile Gly Gly Ala  Arg Tyr Ile Ser Thr  Gly Arg Gly 
    1415                 1420                 1425             


Phe Ala  Thr Ser Arg Ile Pro  Phe Ser Ile Lys Arg  Phe Ala Gly 
    1430                 1435                 1440             


Ser Ala  Ile Tyr Met Gly Ala  Arg Ser Met Leu Met  Leu Leu Phe 
    1445                 1450                 1455             


Gly Thr  Val Ala His Trp Gln  Ala Pro Leu Leu Trp  Phe Trp Ala 
    1460                 1465                 1470             


Ser Leu  Ser Ser Leu Ile Phe  Ala Pro Phe Val Phe  Asn Pro His 
    1475                 1480                 1485             


Gln Phe  Ala Trp Glu Asp Phe  Phe Leu Asp Tyr Arg  Asp Tyr Ile 
    1490                 1495                 1500             


Arg Trp  Leu Ser Arg Gly Asn  Asn Gln Tyr His Arg  Asn Ser Trp 
    1505                 1510                 1515             


Ile Gly  Tyr Val Arg Met Ser  Arg Ala Arg Ile Thr  Gly Phe Lys 
    1520                 1525                 1530             


Arg Lys  Leu Val Gly Asp Glu  Ser Glu Lys Ala Ala  Gly Asp Ala 
    1535                 1540                 1545             


Ser Arg  Ala His Arg Thr Asn  Leu Ile Met Ala Glu  Ile Ile Pro 
    1550                 1555                 1560             


Cys Ala  Ile Tyr Ala Ala Gly  Cys Phe Ile Ala Phe  Thr Phe Ile 
    1565                 1570                 1575             


Asn Ala  Gln Thr Gly Val Lys  Thr Thr Asp Asp Asp  Arg Val Asn 
    1580                 1585                 1590             


Ser Val  Leu Arg Ile Ile Ile  Cys Thr Leu Ala Pro  Ile Ala Val 
    1595                 1600                 1605             


Asn Leu  Gly Val Leu Phe Phe  Cys Met Gly Met Ser  Cys Cys Ser 
    1610                 1615                 1620             


Gly Pro  Leu Phe Gly Met Cys  Cys Lys Lys Thr Gly  Ser Val Met 
    1625                 1630                 1635             


Ala Gly  Ile Ala His Gly Val  Ala Val Ile Val His  Ile Ala Phe 
    1640                 1645                 1650             


Phe Ile  Val Met Trp Val Leu  Glu Ser Phe Asn Phe  Val Arg Met 
    1655                 1660                 1665             


Leu Ile  Gly Val Val Thr Cys  Ile Gln Cys Gln Arg  Leu Ile Phe 
    1670                 1675                 1680             


His Cys  Met Thr Ala Leu Met  Leu Thr Arg Glu Phe  Lys Asn Asp 
    1685                 1690                 1695             


His Ala  Asn Thr Ala Phe Trp  Thr Gly Lys Trp Tyr  Gly Lys Gly 
    1700                 1705                 1710             


Met Gly  Tyr Met Ala Trp Thr  Gln Pro Ser Arg Glu  Leu Thr Ala 
    1715                 1720                 1725             


Lys Val  Ile Glu Leu Ser Glu  Phe Ala Ala Asp Phe  Val Leu Gly 
    1730                 1735                 1740             


His Val  Ile Leu Ile Cys Gln  Leu Pro Leu Ile Ile  Ile Pro Lys 
    1745                 1750                 1755             


Ile Asp  Lys Phe His Ser Ile  Met Leu Phe Trp Leu  Lys Pro Ser 
    1760                 1765                 1770             


Arg Gln  Ile Arg Pro Pro Ile  Tyr Ser Leu Lys Gln  Thr Arg Leu 
    1775                 1780                 1785             


Arg Lys  Arg Met Val Lys Lys  Tyr Cys Ser Leu Tyr  Phe Leu Val 
    1790                 1795                 1800             


Leu Ala  Ile Phe Ala Gly Cys  Ile Ile Gly Pro Ala  Val Ala Ser 
    1805                 1810                 1815             


Ala Lys  Ile His Lys His Ile  Gly Asp Ser Leu Asp  Gly Val Val 
    1820                 1825                 1830             


His Asn  Leu Phe Gln Pro Ile  Asn Thr Thr Asn Asn  Asp Thr Gly 
    1835                 1840                 1845             


Ser Gln  Met Ser Thr Tyr Gln  Ser His Tyr Tyr Thr  His Thr Pro 
    1850                 1855                 1860             


Ser Leu  Lys Thr Trp Ser Thr  Ile Lys 
    1865                 1870         


<210>  7
<211>  5661
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  CDS
<222>  (1)..(5661)
<223>  Saccharomyces cerevisiae FKS2 (codon optimized)

<400>  7
atg tcc tac aac gat ccc aat ctc aat ggc cag tat tac tcc aac ggc         48
Met Ser Tyr Asn Asp Pro Asn Leu Asn Gly Gln Tyr Tyr Ser Asn Gly           
1               5                   10                  15                

gac ggc acc ggc gat ggc aat tat ccg acc tac cag gtg acc cag gat         96
Asp Gly Thr Gly Asp Gly Asn Tyr Pro Thr Tyr Gln Val Thr Gln Asp           
            20                  25                  30                    

caa agc gcg tac gac gag tac ggc cag ccc atc tat acc caa aat caa        144
Gln Ser Ala Tyr Asp Glu Tyr Gly Gln Pro Ile Tyr Thr Gln Asn Gln           
        35                  40                  45                        

ctg gac gat ggc tac tat gac ccg aat gaa caa tac gtg gat ggc acc        192
Leu Asp Asp Gly Tyr Tyr Asp Pro Asn Glu Gln Tyr Val Asp Gly Thr           
    50                  55                  60                            

cag ttc ccg cag ggc cag gac ccg tcg cag gac caa ggc ccg tat aac        240
Gln Phe Pro Gln Gly Gln Asp Pro Ser Gln Asp Gln Gly Pro Tyr Asn           
65                  70                  75                  80            

aat gac gcc agc tat tac aac cag ccg ccg aac atg atg aac ccg tcg        288
Asn Asp Ala Ser Tyr Tyr Asn Gln Pro Pro Asn Met Met Asn Pro Ser           
                85                  90                  95                

tcc cag gac ggt gag aat ttc tcg gac ttc agc tcg tat gga ccg ccc        336
Ser Gln Asp Gly Glu Asn Phe Ser Asp Phe Ser Ser Tyr Gly Pro Pro           
            100                 105                 110                   

tcg gga acg tac cct aat gac cag tat acg ccc agt cag atg tcc tac        384
Ser Gly Thr Tyr Pro Asn Asp Gln Tyr Thr Pro Ser Gln Met Ser Tyr           
        115                 120                 125                       

ccg gat cag gac ggc tcg tcg ggt gcg tcg acg ccg tat ggc aac ggc        432
Pro Asp Gln Asp Gly Ser Ser Gly Ala Ser Thr Pro Tyr Gly Asn Gly           
    130                 135                 140                           

gtc gtc aat ggg aac ggc cag tat tat gat ccg aat gcg atc gag atg        480
Val Val Asn Gly Asn Gly Gln Tyr Tyr Asp Pro Asn Ala Ile Glu Met           
145                 150                 155                 160           

gcg ctg ccc aat gac ccg tat ccg gcg tgg acc gcc gat ccc cag tcc        528
Ala Leu Pro Asn Asp Pro Tyr Pro Ala Trp Thr Ala Asp Pro Gln Ser           
                165                 170                 175               

cct ctc ccc atc gag caa att gag gac atc ttc ata gat ctc acc aat        576
Pro Leu Pro Ile Glu Gln Ile Glu Asp Ile Phe Ile Asp Leu Thr Asn           
            180                 185                 190                   

aag ttc ggc ttc cag cgc gac tcg atg cgg aac atg ttc gac cac ttc        624
Lys Phe Gly Phe Gln Arg Asp Ser Met Arg Asn Met Phe Asp His Phe           
        195                 200                 205                       

atg acc ctg ctg gat tcg cgc agc tcg cgc atg tcg ccg gaa cag gcc        672
Met Thr Leu Leu Asp Ser Arg Ser Ser Arg Met Ser Pro Glu Gln Ala           
    210                 215                 220                           

ttg ctc tcc ctc cat gcc gac tac att ggc ggc gac acc gcc aac tac        720
Leu Leu Ser Leu His Ala Asp Tyr Ile Gly Gly Asp Thr Ala Asn Tyr           
225                 230                 235                 240           

aag aaa tgg tat ttt gcg gcc caa ctg gat atg gac gat gag atc ggc        768
Lys Lys Trp Tyr Phe Ala Ala Gln Leu Asp Met Asp Asp Glu Ile Gly           
                245                 250                 255               

ttc cgg aac atg aaa ctc ggc aag ctg tcc cgc aaa gcg cgc aaa gcg        816
Phe Arg Asn Met Lys Leu Gly Lys Leu Ser Arg Lys Ala Arg Lys Ala           
            260                 265                 270                   

aag aag aaa aac aaa aag gcc atg caa gag gat gag gac act gaa gag        864
Lys Lys Lys Asn Lys Lys Ala Met Gln Glu Asp Glu Asp Thr Glu Glu           
        275                 280                 285                       

act ctg aac cag atc gag ggc gat aac tcc ctc gaa gcc gct gac ttc        912
Thr Leu Asn Gln Ile Glu Gly Asp Asn Ser Leu Glu Ala Ala Asp Phe           
    290                 295                 300                           

cgg tgg aag agt aaa atg aat caa ctc agc ccc ttc gag atg gtg cgg        960
Arg Trp Lys Ser Lys Met Asn Gln Leu Ser Pro Phe Glu Met Val Arg           
305                 310                 315                 320           

caa atc gcc ctc ttc ctc ctg tgc tgg ggc gag gcc aat caa gtg cgg       1008
Gln Ile Ala Leu Phe Leu Leu Cys Trp Gly Glu Ala Asn Gln Val Arg           
                325                 330                 335               

ttc acc ccg gag tgc ctg tgc ttt atc tac aag tgc gcg agc gac tac       1056
Phe Thr Pro Glu Cys Leu Cys Phe Ile Tyr Lys Cys Ala Ser Asp Tyr           
            340                 345                 350                   

ctg gac tcc gcc caa tgc cag cag cgg ccc gac ccc ctg ccc gag ggc       1104
Leu Asp Ser Ala Gln Cys Gln Gln Arg Pro Asp Pro Leu Pro Glu Gly           
        355                 360                 365                       

gac ttt ctc aat cgg gtg atc acg ccc ttg tac cgc ttc att cgc agc       1152
Asp Phe Leu Asn Arg Val Ile Thr Pro Leu Tyr Arg Phe Ile Arg Ser           
    370                 375                 380                           

cag gtg tac gag atc gtc gac ggc cgc tac gtg aag tcc gag aag gac       1200
Gln Val Tyr Glu Ile Val Asp Gly Arg Tyr Val Lys Ser Glu Lys Asp           
385                 390                 395                 400           

cat aac aag gtc att ggt tat gac gac gtc aac caa ctt ttc tgg tat       1248
His Asn Lys Val Ile Gly Tyr Asp Asp Val Asn Gln Leu Phe Trp Tyr           
                405                 410                 415               

ccg gaa ggc atc gcc aag atc gtg atg gag gac ggc acg cgc ctt atc       1296
Pro Glu Gly Ile Ala Lys Ile Val Met Glu Asp Gly Thr Arg Leu Ile           
            420                 425                 430                   

gac ctc ccc gct gag gaa cgg tac ctc aag ctc ggc gag atc ccc tgg       1344
Asp Leu Pro Ala Glu Glu Arg Tyr Leu Lys Leu Gly Glu Ile Pro Trp           
        435                 440                 445                       

gac gat gtg ttc ttc aag acc tat aag gaa acc cgc tcc tgg ctc cat       1392
Asp Asp Val Phe Phe Lys Thr Tyr Lys Glu Thr Arg Ser Trp Leu His           
    450                 455                 460                           

ctg gtg acc aac ttc aat cgg att tgg att atg cac gtg tat tgg atg       1440
Leu Val Thr Asn Phe Asn Arg Ile Trp Ile Met His Val Tyr Trp Met           
465                 470                 475                 480           

tat tgt gca tac aat gcc ccc acc ttc tat acg cac aat tac caa cag       1488
Tyr Cys Ala Tyr Asn Ala Pro Thr Phe Tyr Thr His Asn Tyr Gln Gln           
                485                 490                 495               

ctt gtc gac aac cag ccg ctc gcc gca tac aag tgg gcc acc gct gcc       1536
Leu Val Asp Asn Gln Pro Leu Ala Ala Tyr Lys Trp Ala Thr Ala Ala           
            500                 505                 510                   

ctc ggg ggg acg gtc gcg tcg ttg atc cag gtc gcg gcg acg ctg tgc       1584
Leu Gly Gly Thr Val Ala Ser Leu Ile Gln Val Ala Ala Thr Leu Cys           
        515                 520                 525                       

gag tgg tcc ttc gtg ccg cgg aaa tgg gca ggc gcg cag cac ctg tcc       1632
Glu Trp Ser Phe Val Pro Arg Lys Trp Ala Gly Ala Gln His Leu Ser           
    530                 535                 540                           

cgg cgc ttc tgg ttc ctg tgc gtc atc atg ggc atc aat ctt ggc ccc       1680
Arg Arg Phe Trp Phe Leu Cys Val Ile Met Gly Ile Asn Leu Gly Pro           
545                 550                 555                 560           

gtc atc ttc gtg ttc gcc tat gac aaa gat acg gtc tac tcg acg gcc       1728
Val Ile Phe Val Phe Ala Tyr Asp Lys Asp Thr Val Tyr Ser Thr Ala           
                565                 570                 575               

gca cac gtc gtg ggc gca gtt atg ttc ttt gtc gcc gtg gcg act ctg       1776
Ala His Val Val Gly Ala Val Met Phe Phe Val Ala Val Ala Thr Leu           
            580                 585                 590                   

gtc ttt ttc agc gtc atg ccg ctg ggt ggc ctg ttc acc agt tat atg       1824
Val Phe Phe Ser Val Met Pro Leu Gly Gly Leu Phe Thr Ser Tyr Met           
        595                 600                 605                       

aag aaa agt acc cgg tcg tac gtc gcg agt cag acc ttc acc gcc agc       1872
Lys Lys Ser Thr Arg Ser Tyr Val Ala Ser Gln Thr Phe Thr Ala Ser           
    610                 615                 620                           

ttc gcg cca ctg cat ggg ctg gac cgg tgg atg agt tac ctc gtg tgg       1920
Phe Ala Pro Leu His Gly Leu Asp Arg Trp Met Ser Tyr Leu Val Trp           
625                 630                 635                 640           

gtg acc gtt ttc gcc gcc aaa tat gcg gag tcg tac ttc ttc ctg atc       1968
Val Thr Val Phe Ala Ala Lys Tyr Ala Glu Ser Tyr Phe Phe Leu Ile           
                645                 650                 655               

ctt tcg ctc cgc gat ccg att cgc atc ctg tcg acg acc tcg atg cgc       2016
Leu Ser Leu Arg Asp Pro Ile Arg Ile Leu Ser Thr Thr Ser Met Arg           
            660                 665                 670                   

tgc acg ggc gag tac tgg tgg gga aac aag atc tgc aag gtc caa ccg       2064
Cys Thr Gly Glu Tyr Trp Trp Gly Asn Lys Ile Cys Lys Val Gln Pro           
        675                 680                 685                       

aag atc gtc ttg ggc ctc atg atc gcc acg gac ttc atc ctg ttc ttc       2112
Lys Ile Val Leu Gly Leu Met Ile Ala Thr Asp Phe Ile Leu Phe Phe           
    690                 695                 700                           

ctg gac acc tac ctc tgg tac atc gtc gtg aac acg gtt ttc agc gtc       2160
Leu Asp Thr Tyr Leu Trp Tyr Ile Val Val Asn Thr Val Phe Ser Val           
705                 710                 715                 720           

gga aaa tcg ttc tac ctg ggc atc tcc att ctc acc ccg tgg cgc aac       2208
Gly Lys Ser Phe Tyr Leu Gly Ile Ser Ile Leu Thr Pro Trp Arg Asn           
                725                 730                 735               

atc ttt acc cgg ctg ccc aag cgc ata tac agc aag atc ctg gcc acc       2256
Ile Phe Thr Arg Leu Pro Lys Arg Ile Tyr Ser Lys Ile Leu Ala Thr           
            740                 745                 750                   

acc gac atg gag atc aag tac aaa ccc aag gtc ctc atc agc cag atc       2304
Thr Asp Met Glu Ile Lys Tyr Lys Pro Lys Val Leu Ile Ser Gln Ile           
        755                 760                 765                       

tgg aat gcg ata atc ata tcc atg tat cgc gag cat ctt ctg gcg atc       2352
Trp Asn Ala Ile Ile Ile Ser Met Tyr Arg Glu His Leu Leu Ala Ile           
    770                 775                 780                           

gac cat gtc caa aag ctg ctg tat cat cag gtg ccg agc gag atc gag       2400
Asp His Val Gln Lys Leu Leu Tyr His Gln Val Pro Ser Glu Ile Glu           
785                 790                 795                 800           

ggt aag cgc acc ttg cgc gct ccg acc ttc ttc gtt tcg caa gac gat       2448
Gly Lys Arg Thr Leu Arg Ala Pro Thr Phe Phe Val Ser Gln Asp Asp           
                805                 810                 815               

aac aac ttc gag act gag ttc ttc cca agg gat tcc gag gcc gag cgc       2496
Asn Asn Phe Glu Thr Glu Phe Phe Pro Arg Asp Ser Glu Ala Glu Arg           
            820                 825                 830                   

cgg atc agc ttt ttc gcg cag agc ctt tcc acc ccc atc ccc gag ccg       2544
Arg Ile Ser Phe Phe Ala Gln Ser Leu Ser Thr Pro Ile Pro Glu Pro           
        835                 840                 845                       

ctg ccg gtg gac aac atg ccc acg ttc acg gtt ctg acc ccg cat tac       2592
Leu Pro Val Asp Asn Met Pro Thr Phe Thr Val Leu Thr Pro His Tyr           
    850                 855                 860                           

gcc gag cgc atc ttg ctg agc ctg cgg gaa atc atc cgc gag gac gac       2640
Ala Glu Arg Ile Leu Leu Ser Leu Arg Glu Ile Ile Arg Glu Asp Asp           
865                 870                 875                 880           

cag ttc agc cgc gtg acc ctc ctg gag tat ctg aag caa ctc cat ccc       2688
Gln Phe Ser Arg Val Thr Leu Leu Glu Tyr Leu Lys Gln Leu His Pro           
                885                 890                 895               

gtg gag tgg gat tgc ttc gtc aaa gac acc aag atc ctg gcc gag gaa       2736
Val Glu Trp Asp Cys Phe Val Lys Asp Thr Lys Ile Leu Ala Glu Glu           
            900                 905                 910                   

acc gcc gct tac gaa aac aac gag gac gag cct gag aag gag gac gcg       2784
Thr Ala Ala Tyr Glu Asn Asn Glu Asp Glu Pro Glu Lys Glu Asp Ala           
        915                 920                 925                       

ctc aaa agt cag atc gac gac ttg ccg ttc tac tgc att gga ttc aaa       2832
Leu Lys Ser Gln Ile Asp Asp Leu Pro Phe Tyr Cys Ile Gly Phe Lys           
    930                 935                 940                           

tcg gcg gca ccg gag tac acg ctt cgg acc cgg atc tgg gcg agc ctc       2880
Ser Ala Ala Pro Glu Tyr Thr Leu Arg Thr Arg Ile Trp Ala Ser Leu           
945                 950                 955                 960           

cgc tcg cag acc ctc tat cgg acc atc tcg gga ttc atg aat tac tcc       2928
Arg Ser Gln Thr Leu Tyr Arg Thr Ile Ser Gly Phe Met Asn Tyr Ser           
                965                 970                 975               

cgg gca atc aag ctg ctg tat cgc gtg gag aac ccg gag atc gtg caa       2976
Arg Ala Ile Lys Leu Leu Tyr Arg Val Glu Asn Pro Glu Ile Val Gln           
            980                 985                 990                   

atg ttc ggc ggc aat gcc gac ggc  ctg gag cgc gag ctt  gag aag atg     3024
Met Phe Gly Gly Asn Ala Asp Gly  Leu Glu Arg Glu Leu  Glu Lys Met         
        995                 1000                 1005                     

gcg agg  cgc aag ttc aag ttc  ctc gtg agt atg cag  cgc ctg gca        3069
Ala Arg  Arg Lys Phe Lys Phe  Leu Val Ser Met Gln  Arg Leu Ala            
    1010                 1015                 1020                        

aag ttc  aag ttc ctg gag aac  gcc gag ttc ctg ctt  cgg gcg tat        3114
Lys Phe  Lys Phe Leu Glu Asn  Ala Glu Phe Leu Leu  Arg Ala Tyr            
    1025                 1030                 1035                        

ccg gac  ctc cag atc gcc tac  ctg gac gaa gaa ccg  ccc ctg aat        3159
Pro Asp  Leu Gln Ile Ala Tyr  Leu Asp Glu Glu Pro  Pro Leu Asn            
    1040                 1045                 1050                        

gag ggc  gag gag cca cgc atc  tat tcc gcg ctc atc  gac ggc cac        3204
Glu Gly  Glu Glu Pro Arg Ile  Tyr Ser Ala Leu Ile  Asp Gly His            
    1055                 1060                 1065                        

tgc gag  att aat ggc cgc cgg  cgc ccg aag ttc agg  gtc cag ctc        3249
Cys Glu  Ile Asn Gly Arg Arg  Arg Pro Lys Phe Arg  Val Gln Leu            
    1070                 1075                 1080                        

tcc ggc  aac ccg att ttg ggc  gat ggg aaa tcg gac  aac cag aat        3294
Ser Gly  Asn Pro Ile Leu Gly  Asp Gly Lys Ser Asp  Asn Gln Asn            
    1085                 1090                 1095                        

cat gcg  ctc atc ttc tat cgc  ggc gag tac att cag  ctg atc gac        3339
His Ala  Leu Ile Phe Tyr Arg  Gly Glu Tyr Ile Gln  Leu Ile Asp            
    1100                 1105                 1110                        

gcc aac  caa gat aac tat ctt  gag gag tgc ctg aag  atc cgc tcg        3384
Ala Asn  Gln Asp Asn Tyr Leu  Glu Glu Cys Leu Lys  Ile Arg Ser            
    1115                 1120                 1125                        

gtg ctg  gcg gag ttt gag gaa  ctc ggt att gaa cag  ata cac ccg        3429
Val Leu  Ala Glu Phe Glu Glu  Leu Gly Ile Glu Gln  Ile His Pro            
    1130                 1135                 1140                        

tat acc  ccc gga ctc aag tac  gag gac cag tcg acg  aat cat cca        3474
Tyr Thr  Pro Gly Leu Lys Tyr  Glu Asp Gln Ser Thr  Asn His Pro            
    1145                 1150                 1155                        

gtg gct  atc gtc ggt gcc cgc  gag tat atc ttc agc  gag aac tcc        3519
Val Ala  Ile Val Gly Ala Arg  Glu Tyr Ile Phe Ser  Glu Asn Ser            
    1160                 1165                 1170                        

ggt gtc  ctc ggc gac gtg gcg  gct ggc aag gaa cag  acc ttc ggc        3564
Gly Val  Leu Gly Asp Val Ala  Ala Gly Lys Glu Gln  Thr Phe Gly            
    1175                 1180                 1185                        

acc ctc  ttc gcc cgg acc ctc  gcg cag atc ggc ggc  aag ctg cac        3609
Thr Leu  Phe Ala Arg Thr Leu  Ala Gln Ile Gly Gly  Lys Leu His            
    1190                 1195                 1200                        

tac ggc  cat ccg gac ttc atc  aac gcg acc ttc atg  acg acc cgg        3654
Tyr Gly  His Pro Asp Phe Ile  Asn Ala Thr Phe Met  Thr Thr Arg            
    1205                 1210                 1215                        

ggt ggg  gtc agc aag gcc cag  aaa ggg ctg cat ctc  aat gaa gat        3699
Gly Gly  Val Ser Lys Ala Gln  Lys Gly Leu His Leu  Asn Glu Asp            
    1220                 1225                 1230                        

atc tac  gcg ggg atg aac gct  gtc ctc cgc ggt ggc  cgc att aag        3744
Ile Tyr  Ala Gly Met Asn Ala  Val Leu Arg Gly Gly  Arg Ile Lys            
    1235                 1240                 1245                        

cac tgc  gag tat tac cag tgc  ggc aag ggt cgc gac  ttg ggc ttt        3789
His Cys  Glu Tyr Tyr Gln Cys  Gly Lys Gly Arg Asp  Leu Gly Phe            
    1250                 1255                 1260                        

ggc acc  atc ctc aac ttc acg  acg aaa atc ggc gct  ggc atg ggc        3834
Gly Thr  Ile Leu Asn Phe Thr  Thr Lys Ile Gly Ala  Gly Met Gly            
    1265                 1270                 1275                        

gag caa  atg ctg agt cgg gag  tac tat tac ctg ggc  acc cag ctg        3879
Glu Gln  Met Leu Ser Arg Glu  Tyr Tyr Tyr Leu Gly  Thr Gln Leu            
    1280                 1285                 1290                        

cca atc  gac cgc ttc ctc acc  ttc tac tat gcg cat  ccc ggc ttc        3924
Pro Ile  Asp Arg Phe Leu Thr  Phe Tyr Tyr Ala His  Pro Gly Phe            
    1295                 1300                 1305                        

cat ctg  aat aac ctg ttc ata  cag ctg tcg ctg cag  atg ttc atg        3969
His Leu  Asn Asn Leu Phe Ile  Gln Leu Ser Leu Gln  Met Phe Met            
    1310                 1315                 1320                        

ctg act  ctg gtc aac ctc cac  gca ctc gcg cat gag  agc att ttg        4014
Leu Thr  Leu Val Asn Leu His  Ala Leu Ala His Glu  Ser Ile Leu            
    1325                 1330                 1335                        

tgc gtg  tat gac agg gat aaa  ccg atc acc gac gtc  ctc tat cct        4059
Cys Val  Tyr Asp Arg Asp Lys  Pro Ile Thr Asp Val  Leu Tyr Pro            
    1340                 1345                 1350                        

atc ggt  tgc tat aac ttc cat  ccg gcg atc gac tgg  gtt cgc cgc        4104
Ile Gly  Cys Tyr Asn Phe His  Pro Ala Ile Asp Trp  Val Arg Arg            
    1355                 1360                 1365                        

tac acc  ctg agc atc ttt atc  gtg ttc tgg ata gcg  ttc gtc ccg        4149
Tyr Thr  Leu Ser Ile Phe Ile  Val Phe Trp Ile Ala  Phe Val Pro            
    1370                 1375                 1380                        

atc gtc  gtc cag gag ctg atc  gag agg ggc ctg tgg  aag gcc acg        4194
Ile Val  Val Gln Glu Leu Ile  Glu Arg Gly Leu Trp  Lys Ala Thr            
    1385                 1390                 1395                        

cag cgg  ttc ttc agg cac atc  ttg tcg ctc agc ccg  atg ttc gaa        4239
Gln Arg  Phe Phe Arg His Ile  Leu Ser Leu Ser Pro  Met Phe Glu            
    1400                 1405                 1410                        

gtg ttc  gcg ggt cag atc tat  tcc agc gcg ctc ctg  agc gac att        4284
Val Phe  Ala Gly Gln Ile Tyr  Ser Ser Ala Leu Leu  Ser Asp Ile            
    1415                 1420                 1425                        

gcc gtg  ggc ggc gcc cgg tac  atc tcc acg ggc cgc  ggt ttc gcg        4329
Ala Val  Gly Gly Ala Arg Tyr  Ile Ser Thr Gly Arg  Gly Phe Ala            
    1430                 1435                 1440                        

acc tcc  cgc atc ccg ttc tcg  atc ctc tat tcg cgc  ttc gcg ggc        4374
Thr Ser  Arg Ile Pro Phe Ser  Ile Leu Tyr Ser Arg  Phe Ala Gly            
    1445                 1450                 1455                        

agc gcg  atc tac atg ggt tcc  cgg agc atg ctc atg  ctc ctg ttc        4419
Ser Ala  Ile Tyr Met Gly Ser  Arg Ser Met Leu Met  Leu Leu Phe            
    1460                 1465                 1470                        

ggc acc  gtc gcc cac tgg cag  gct ccc ctg ctt tgg  ttc tgg gcg        4464
Gly Thr  Val Ala His Trp Gln  Ala Pro Leu Leu Trp  Phe Trp Ala            
    1475                 1480                 1485                        

agc ctt  agc gcg ctg atc ttc  gcc ccg ttc atc ttc  aat ccg cat        4509
Ser Leu  Ser Ala Leu Ile Phe  Ala Pro Phe Ile Phe  Asn Pro His            
    1490                 1495                 1500                        

cag ttc  gcc tgg gag gac ttc  ttc ctc gac tat agg  gac tac atc        4554
Gln Phe  Ala Trp Glu Asp Phe  Phe Leu Asp Tyr Arg  Asp Tyr Ile            
    1505                 1510                 1515                        

cgc tgg  ctg tcc cgc gga aac  aac aag tat cac cgc  aac tcg tgg        4599
Arg Trp  Leu Ser Arg Gly Asn  Asn Lys Tyr His Arg  Asn Ser Trp            
    1520                 1525                 1530                        

atc ggt  tac gtg cgc atg tcg  cgg tcc cgg gtg acg  ggt ttc aag        4644
Ile Gly  Tyr Val Arg Met Ser  Arg Ser Arg Val Thr  Gly Phe Lys            
    1535                 1540                 1545                        

cgc aag  ctc gtc ggc gat gag  tcg gag aag agt gcc  ggg gac gcc        4689
Arg Lys  Leu Val Gly Asp Glu  Ser Glu Lys Ser Ala  Gly Asp Ala            
    1550                 1555                 1560                        

tcc cgc  gcc cat cgc acc aac  ctc atc atg gcc gag  atc atc ccg        4734
Ser Arg  Ala His Arg Thr Asn  Leu Ile Met Ala Glu  Ile Ile Pro            
    1565                 1570                 1575                        

tgc gcc  atc tac gcg gca ggc  tgc ttc atc gcc ttc  acc ttt atc        4779
Cys Ala  Ile Tyr Ala Ala Gly  Cys Phe Ile Ala Phe  Thr Phe Ile            
    1580                 1585                 1590                        

aac gcg  cag acc ggc gtc aag  acc acc gat gag gac  cgc gtg aac        4824
Asn Ala  Gln Thr Gly Val Lys  Thr Thr Asp Glu Asp  Arg Val Asn            
    1595                 1600                 1605                        

tcc acg  ctg cgc atc atc atc  tgt acc ctg gca ccg  atc gtc ata        4869
Ser Thr  Leu Arg Ile Ile Ile  Cys Thr Leu Ala Pro  Ile Val Ile            
    1610                 1615                 1620                        

gac atc  ggg gtg ctg ttc ttc  tgc atg ggc ttg agc  tgt tgc tcg        4914
Asp Ile  Gly Val Leu Phe Phe  Cys Met Gly Leu Ser  Cys Cys Ser            
    1625                 1630                 1635                        

gga ccg  ctg ctc ggc atg tgc  tgc aag aaa act ggc  agc gtc atg        4959
Gly Pro  Leu Leu Gly Met Cys  Cys Lys Lys Thr Gly  Ser Val Met            
    1640                 1645                 1650                        

gcc ggc  att gcc cat ggc atc  gcc gtc gtc gtc cat  att gtc ttt        5004
Ala Gly  Ile Ala His Gly Ile  Ala Val Val Val His  Ile Val Phe            
    1655                 1660                 1665                        

ttc atc  gtc atg tgg gtg ctc  gaa ggc ttc tcc ttc  gtc cgc atg        5049
Phe Ile  Val Met Trp Val Leu  Glu Gly Phe Ser Phe  Val Arg Met            
    1670                 1675                 1680                        

ctg atc  ggt gtc gtg acg tgc  atc cag tgt cag cgg  ctt atc ttt        5094
Leu Ile  Gly Val Val Thr Cys  Ile Gln Cys Gln Arg  Leu Ile Phe            
    1685                 1690                 1695                        

cat tgc  atg acc gtg ctc ctc  ctc acg cgg gaa ttc  aag aat gac        5139
His Cys  Met Thr Val Leu Leu  Leu Thr Arg Glu Phe  Lys Asn Asp            
    1700                 1705                 1710                        

cac gcc  aac acc gcg ttc tgg  acc ggc aag tgg tat  tcg acg gga        5184
His Ala  Asn Thr Ala Phe Trp  Thr Gly Lys Trp Tyr  Ser Thr Gly            
    1715                 1720                 1725                        

ctc ggt  tat atg gcc tgg acg  cag cca acg cgc gag  ctg acg gca        5229
Leu Gly  Tyr Met Ala Trp Thr  Gln Pro Thr Arg Glu  Leu Thr Ala            
    1730                 1735                 1740                        

aag gtt  atc gag ctg agc gaa  ttc gcg gct gac ttc  gtg ctg ggc        5274
Lys Val  Ile Glu Leu Ser Glu  Phe Ala Ala Asp Phe  Val Leu Gly            
    1745                 1750                 1755                        

cat gtc  atc ctc atc ttc cag  ctc ccg gtt atc tgc  atc ccg aag        5319
His Val  Ile Leu Ile Phe Gln  Leu Pro Val Ile Cys  Ile Pro Lys            
    1760                 1765                 1770                        

atc gac  aaa ttc cac tcg att  atg ctc ttt tgg ctg  aag ccg tcg        5364
Ile Asp  Lys Phe His Ser Ile  Met Leu Phe Trp Leu  Lys Pro Ser            
    1775                 1780                 1785                        

cgc caa  atc cgc cct ccg atc  tac tcc ctg aaa cag  gcg cgc ctg        5409
Arg Gln  Ile Arg Pro Pro Ile  Tyr Ser Leu Lys Gln  Ala Arg Leu            
    1790                 1795                 1800                        

cgc aag  cgc atg gtc cgg cgc  tac tgc tcc ctc tac  ttc ctg gtg        5454
Arg Lys  Arg Met Val Arg Arg  Tyr Cys Ser Leu Tyr  Phe Leu Val            
    1805                 1810                 1815                        

ctg atc  atc ttc gcg ggt tgc  atc gtg ggt ccc gcc  gtg gcg tcg        5499
Leu Ile  Ile Phe Ala Gly Cys  Ile Val Gly Pro Ala  Val Ala Ser            
    1820                 1825                 1830                        

gct cac  gtg ccg aaa gac ctg  ggc tcc ggg ctg acc  ggc acc ttt        5544
Ala His  Val Pro Lys Asp Leu  Gly Ser Gly Leu Thr  Gly Thr Phe            
    1835                 1840                 1845                        

cat aac  ctg gtg cag ccg cgc  aac gtc agc aat aat  gac acg ggc        5589
His Asn  Leu Val Gln Pro Arg  Asn Val Ser Asn Asn  Asp Thr Gly            
    1850                 1855                 1860                        

tcg caa  atg tcc acc tat aag  tcg cat tac tac acc  cat acc ccg        5634
Ser Gln  Met Ser Thr Tyr Lys  Ser His Tyr Tyr Thr  His Thr Pro            
    1865                 1870                 1875                        

tcg ctc  aaa acc tgg tcg acc  att aaa                                 5661
Ser Leu  Lys Thr Trp Ser Thr  Ile Lys                                     
    1880                 1885                                             


<210>  8
<211>  1887
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  8

Met Ser Tyr Asn Asp Pro Asn Leu Asn Gly Gln Tyr Tyr Ser Asn Gly 
1               5                   10                  15      


Asp Gly Thr Gly Asp Gly Asn Tyr Pro Thr Tyr Gln Val Thr Gln Asp 
            20                  25                  30          


Gln Ser Ala Tyr Asp Glu Tyr Gly Gln Pro Ile Tyr Thr Gln Asn Gln 
        35                  40                  45              


Leu Asp Asp Gly Tyr Tyr Asp Pro Asn Glu Gln Tyr Val Asp Gly Thr 
    50                  55                  60                  


Gln Phe Pro Gln Gly Gln Asp Pro Ser Gln Asp Gln Gly Pro Tyr Asn 
65                  70                  75                  80  


Asn Asp Ala Ser Tyr Tyr Asn Gln Pro Pro Asn Met Met Asn Pro Ser 
                85                  90                  95      


Ser Gln Asp Gly Glu Asn Phe Ser Asp Phe Ser Ser Tyr Gly Pro Pro 
            100                 105                 110         


Ser Gly Thr Tyr Pro Asn Asp Gln Tyr Thr Pro Ser Gln Met Ser Tyr 
        115                 120                 125             


Pro Asp Gln Asp Gly Ser Ser Gly Ala Ser Thr Pro Tyr Gly Asn Gly 
    130                 135                 140                 


Val Val Asn Gly Asn Gly Gln Tyr Tyr Asp Pro Asn Ala Ile Glu Met 
145                 150                 155                 160 


Ala Leu Pro Asn Asp Pro Tyr Pro Ala Trp Thr Ala Asp Pro Gln Ser 
                165                 170                 175     


Pro Leu Pro Ile Glu Gln Ile Glu Asp Ile Phe Ile Asp Leu Thr Asn 
            180                 185                 190         


Lys Phe Gly Phe Gln Arg Asp Ser Met Arg Asn Met Phe Asp His Phe 
        195                 200                 205             


Met Thr Leu Leu Asp Ser Arg Ser Ser Arg Met Ser Pro Glu Gln Ala 
    210                 215                 220                 


Leu Leu Ser Leu His Ala Asp Tyr Ile Gly Gly Asp Thr Ala Asn Tyr 
225                 230                 235                 240 


Lys Lys Trp Tyr Phe Ala Ala Gln Leu Asp Met Asp Asp Glu Ile Gly 
                245                 250                 255     


Phe Arg Asn Met Lys Leu Gly Lys Leu Ser Arg Lys Ala Arg Lys Ala 
            260                 265                 270         


Lys Lys Lys Asn Lys Lys Ala Met Gln Glu Asp Glu Asp Thr Glu Glu 
        275                 280                 285             


Thr Leu Asn Gln Ile Glu Gly Asp Asn Ser Leu Glu Ala Ala Asp Phe 
    290                 295                 300                 


Arg Trp Lys Ser Lys Met Asn Gln Leu Ser Pro Phe Glu Met Val Arg 
305                 310                 315                 320 


Gln Ile Ala Leu Phe Leu Leu Cys Trp Gly Glu Ala Asn Gln Val Arg 
                325                 330                 335     


Phe Thr Pro Glu Cys Leu Cys Phe Ile Tyr Lys Cys Ala Ser Asp Tyr 
            340                 345                 350         


Leu Asp Ser Ala Gln Cys Gln Gln Arg Pro Asp Pro Leu Pro Glu Gly 
        355                 360                 365             


Asp Phe Leu Asn Arg Val Ile Thr Pro Leu Tyr Arg Phe Ile Arg Ser 
    370                 375                 380                 


Gln Val Tyr Glu Ile Val Asp Gly Arg Tyr Val Lys Ser Glu Lys Asp 
385                 390                 395                 400 


His Asn Lys Val Ile Gly Tyr Asp Asp Val Asn Gln Leu Phe Trp Tyr 
                405                 410                 415     


Pro Glu Gly Ile Ala Lys Ile Val Met Glu Asp Gly Thr Arg Leu Ile 
            420                 425                 430         


Asp Leu Pro Ala Glu Glu Arg Tyr Leu Lys Leu Gly Glu Ile Pro Trp 
        435                 440                 445             


Asp Asp Val Phe Phe Lys Thr Tyr Lys Glu Thr Arg Ser Trp Leu His 
    450                 455                 460                 


Leu Val Thr Asn Phe Asn Arg Ile Trp Ile Met His Val Tyr Trp Met 
465                 470                 475                 480 


Tyr Cys Ala Tyr Asn Ala Pro Thr Phe Tyr Thr His Asn Tyr Gln Gln 
                485                 490                 495     


Leu Val Asp Asn Gln Pro Leu Ala Ala Tyr Lys Trp Ala Thr Ala Ala 
            500                 505                 510         


Leu Gly Gly Thr Val Ala Ser Leu Ile Gln Val Ala Ala Thr Leu Cys 
        515                 520                 525             


Glu Trp Ser Phe Val Pro Arg Lys Trp Ala Gly Ala Gln His Leu Ser 
    530                 535                 540                 


Arg Arg Phe Trp Phe Leu Cys Val Ile Met Gly Ile Asn Leu Gly Pro 
545                 550                 555                 560 


Val Ile Phe Val Phe Ala Tyr Asp Lys Asp Thr Val Tyr Ser Thr Ala 
                565                 570                 575     


Ala His Val Val Gly Ala Val Met Phe Phe Val Ala Val Ala Thr Leu 
            580                 585                 590         


Val Phe Phe Ser Val Met Pro Leu Gly Gly Leu Phe Thr Ser Tyr Met 
        595                 600                 605             


Lys Lys Ser Thr Arg Ser Tyr Val Ala Ser Gln Thr Phe Thr Ala Ser 
    610                 615                 620                 


Phe Ala Pro Leu His Gly Leu Asp Arg Trp Met Ser Tyr Leu Val Trp 
625                 630                 635                 640 


Val Thr Val Phe Ala Ala Lys Tyr Ala Glu Ser Tyr Phe Phe Leu Ile 
                645                 650                 655     


Leu Ser Leu Arg Asp Pro Ile Arg Ile Leu Ser Thr Thr Ser Met Arg 
            660                 665                 670         


Cys Thr Gly Glu Tyr Trp Trp Gly Asn Lys Ile Cys Lys Val Gln Pro 
        675                 680                 685             


Lys Ile Val Leu Gly Leu Met Ile Ala Thr Asp Phe Ile Leu Phe Phe 
    690                 695                 700                 


Leu Asp Thr Tyr Leu Trp Tyr Ile Val Val Asn Thr Val Phe Ser Val 
705                 710                 715                 720 


Gly Lys Ser Phe Tyr Leu Gly Ile Ser Ile Leu Thr Pro Trp Arg Asn 
                725                 730                 735     


Ile Phe Thr Arg Leu Pro Lys Arg Ile Tyr Ser Lys Ile Leu Ala Thr 
            740                 745                 750         


Thr Asp Met Glu Ile Lys Tyr Lys Pro Lys Val Leu Ile Ser Gln Ile 
        755                 760                 765             


Trp Asn Ala Ile Ile Ile Ser Met Tyr Arg Glu His Leu Leu Ala Ile 
    770                 775                 780                 


Asp His Val Gln Lys Leu Leu Tyr His Gln Val Pro Ser Glu Ile Glu 
785                 790                 795                 800 


Gly Lys Arg Thr Leu Arg Ala Pro Thr Phe Phe Val Ser Gln Asp Asp 
                805                 810                 815     


Asn Asn Phe Glu Thr Glu Phe Phe Pro Arg Asp Ser Glu Ala Glu Arg 
            820                 825                 830         


Arg Ile Ser Phe Phe Ala Gln Ser Leu Ser Thr Pro Ile Pro Glu Pro 
        835                 840                 845             


Leu Pro Val Asp Asn Met Pro Thr Phe Thr Val Leu Thr Pro His Tyr 
    850                 855                 860                 


Ala Glu Arg Ile Leu Leu Ser Leu Arg Glu Ile Ile Arg Glu Asp Asp 
865                 870                 875                 880 


Gln Phe Ser Arg Val Thr Leu Leu Glu Tyr Leu Lys Gln Leu His Pro 
                885                 890                 895     


Val Glu Trp Asp Cys Phe Val Lys Asp Thr Lys Ile Leu Ala Glu Glu 
            900                 905                 910         


Thr Ala Ala Tyr Glu Asn Asn Glu Asp Glu Pro Glu Lys Glu Asp Ala 
        915                 920                 925             


Leu Lys Ser Gln Ile Asp Asp Leu Pro Phe Tyr Cys Ile Gly Phe Lys 
    930                 935                 940                 


Ser Ala Ala Pro Glu Tyr Thr Leu Arg Thr Arg Ile Trp Ala Ser Leu 
945                 950                 955                 960 


Arg Ser Gln Thr Leu Tyr Arg Thr Ile Ser Gly Phe Met Asn Tyr Ser 
                965                 970                 975     


Arg Ala Ile Lys Leu Leu Tyr Arg Val Glu Asn Pro Glu Ile Val Gln 
            980                 985                 990         


Met Phe Gly Gly Asn Ala Asp Gly  Leu Glu Arg Glu Leu  Glu Lys Met 
        995                 1000                 1005             


Ala Arg  Arg Lys Phe Lys Phe  Leu Val Ser Met Gln  Arg Leu Ala 
    1010                 1015                 1020             


Lys Phe  Lys Phe Leu Glu Asn  Ala Glu Phe Leu Leu  Arg Ala Tyr 
    1025                 1030                 1035             


Pro Asp  Leu Gln Ile Ala Tyr  Leu Asp Glu Glu Pro  Pro Leu Asn 
    1040                 1045                 1050             


Glu Gly  Glu Glu Pro Arg Ile  Tyr Ser Ala Leu Ile  Asp Gly His 
    1055                 1060                 1065             


Cys Glu  Ile Asn Gly Arg Arg  Arg Pro Lys Phe Arg  Val Gln Leu 
    1070                 1075                 1080             


Ser Gly  Asn Pro Ile Leu Gly  Asp Gly Lys Ser Asp  Asn Gln Asn 
    1085                 1090                 1095             


His Ala  Leu Ile Phe Tyr Arg  Gly Glu Tyr Ile Gln  Leu Ile Asp 
    1100                 1105                 1110             


Ala Asn  Gln Asp Asn Tyr Leu  Glu Glu Cys Leu Lys  Ile Arg Ser 
    1115                 1120                 1125             


Val Leu  Ala Glu Phe Glu Glu  Leu Gly Ile Glu Gln  Ile His Pro 
    1130                 1135                 1140             


Tyr Thr  Pro Gly Leu Lys Tyr  Glu Asp Gln Ser Thr  Asn His Pro 
    1145                 1150                 1155             


Val Ala  Ile Val Gly Ala Arg  Glu Tyr Ile Phe Ser  Glu Asn Ser 
    1160                 1165                 1170             


Gly Val  Leu Gly Asp Val Ala  Ala Gly Lys Glu Gln  Thr Phe Gly 
    1175                 1180                 1185             


Thr Leu  Phe Ala Arg Thr Leu  Ala Gln Ile Gly Gly  Lys Leu His 
    1190                 1195                 1200             


Tyr Gly  His Pro Asp Phe Ile  Asn Ala Thr Phe Met  Thr Thr Arg 
    1205                 1210                 1215             


Gly Gly  Val Ser Lys Ala Gln  Lys Gly Leu His Leu  Asn Glu Asp 
    1220                 1225                 1230             


Ile Tyr  Ala Gly Met Asn Ala  Val Leu Arg Gly Gly  Arg Ile Lys 
    1235                 1240                 1245             


His Cys  Glu Tyr Tyr Gln Cys  Gly Lys Gly Arg Asp  Leu Gly Phe 
    1250                 1255                 1260             


Gly Thr  Ile Leu Asn Phe Thr  Thr Lys Ile Gly Ala  Gly Met Gly 
    1265                 1270                 1275             


Glu Gln  Met Leu Ser Arg Glu  Tyr Tyr Tyr Leu Gly  Thr Gln Leu 
    1280                 1285                 1290             


Pro Ile  Asp Arg Phe Leu Thr  Phe Tyr Tyr Ala His  Pro Gly Phe 
    1295                 1300                 1305             


His Leu  Asn Asn Leu Phe Ile  Gln Leu Ser Leu Gln  Met Phe Met 
    1310                 1315                 1320             


Leu Thr  Leu Val Asn Leu His  Ala Leu Ala His Glu  Ser Ile Leu 
    1325                 1330                 1335             


Cys Val  Tyr Asp Arg Asp Lys  Pro Ile Thr Asp Val  Leu Tyr Pro 
    1340                 1345                 1350             


Ile Gly  Cys Tyr Asn Phe His  Pro Ala Ile Asp Trp  Val Arg Arg 
    1355                 1360                 1365             


Tyr Thr  Leu Ser Ile Phe Ile  Val Phe Trp Ile Ala  Phe Val Pro 
    1370                 1375                 1380             


Ile Val  Val Gln Glu Leu Ile  Glu Arg Gly Leu Trp  Lys Ala Thr 
    1385                 1390                 1395             


Gln Arg  Phe Phe Arg His Ile  Leu Ser Leu Ser Pro  Met Phe Glu 
    1400                 1405                 1410             


Val Phe  Ala Gly Gln Ile Tyr  Ser Ser Ala Leu Leu  Ser Asp Ile 
    1415                 1420                 1425             


Ala Val  Gly Gly Ala Arg Tyr  Ile Ser Thr Gly Arg  Gly Phe Ala 
    1430                 1435                 1440             


Thr Ser  Arg Ile Pro Phe Ser  Ile Leu Tyr Ser Arg  Phe Ala Gly 
    1445                 1450                 1455             


Ser Ala  Ile Tyr Met Gly Ser  Arg Ser Met Leu Met  Leu Leu Phe 
    1460                 1465                 1470             


Gly Thr  Val Ala His Trp Gln  Ala Pro Leu Leu Trp  Phe Trp Ala 
    1475                 1480                 1485             


Ser Leu  Ser Ala Leu Ile Phe  Ala Pro Phe Ile Phe  Asn Pro His 
    1490                 1495                 1500             


Gln Phe  Ala Trp Glu Asp Phe  Phe Leu Asp Tyr Arg  Asp Tyr Ile 
    1505                 1510                 1515             


Arg Trp  Leu Ser Arg Gly Asn  Asn Lys Tyr His Arg  Asn Ser Trp 
    1520                 1525                 1530             


Ile Gly  Tyr Val Arg Met Ser  Arg Ser Arg Val Thr  Gly Phe Lys 
    1535                 1540                 1545             


Arg Lys  Leu Val Gly Asp Glu  Ser Glu Lys Ser Ala  Gly Asp Ala 
    1550                 1555                 1560             


Ser Arg  Ala His Arg Thr Asn  Leu Ile Met Ala Glu  Ile Ile Pro 
    1565                 1570                 1575             


Cys Ala  Ile Tyr Ala Ala Gly  Cys Phe Ile Ala Phe  Thr Phe Ile 
    1580                 1585                 1590             


Asn Ala  Gln Thr Gly Val Lys  Thr Thr Asp Glu Asp  Arg Val Asn 
    1595                 1600                 1605             


Ser Thr  Leu Arg Ile Ile Ile  Cys Thr Leu Ala Pro  Ile Val Ile 
    1610                 1615                 1620             


Asp Ile  Gly Val Leu Phe Phe  Cys Met Gly Leu Ser  Cys Cys Ser 
    1625                 1630                 1635             


Gly Pro  Leu Leu Gly Met Cys  Cys Lys Lys Thr Gly  Ser Val Met 
    1640                 1645                 1650             


Ala Gly  Ile Ala His Gly Ile  Ala Val Val Val His  Ile Val Phe 
    1655                 1660                 1665             


Phe Ile  Val Met Trp Val Leu  Glu Gly Phe Ser Phe  Val Arg Met 
    1670                 1675                 1680             


Leu Ile  Gly Val Val Thr Cys  Ile Gln Cys Gln Arg  Leu Ile Phe 
    1685                 1690                 1695             


His Cys  Met Thr Val Leu Leu  Leu Thr Arg Glu Phe  Lys Asn Asp 
    1700                 1705                 1710             


His Ala  Asn Thr Ala Phe Trp  Thr Gly Lys Trp Tyr  Ser Thr Gly 
    1715                 1720                 1725             


Leu Gly  Tyr Met Ala Trp Thr  Gln Pro Thr Arg Glu  Leu Thr Ala 
    1730                 1735                 1740             


Lys Val  Ile Glu Leu Ser Glu  Phe Ala Ala Asp Phe  Val Leu Gly 
    1745                 1750                 1755             


His Val  Ile Leu Ile Phe Gln  Leu Pro Val Ile Cys  Ile Pro Lys 
    1760                 1765                 1770             


Ile Asp  Lys Phe His Ser Ile  Met Leu Phe Trp Leu  Lys Pro Ser 
    1775                 1780                 1785             


Arg Gln  Ile Arg Pro Pro Ile  Tyr Ser Leu Lys Gln  Ala Arg Leu 
    1790                 1795                 1800             


Arg Lys  Arg Met Val Arg Arg  Tyr Cys Ser Leu Tyr  Phe Leu Val 
    1805                 1810                 1815             


Leu Ile  Ile Phe Ala Gly Cys  Ile Val Gly Pro Ala  Val Ala Ser 
    1820                 1825                 1830             


Ala His  Val Pro Lys Asp Leu  Gly Ser Gly Leu Thr  Gly Thr Phe 
    1835                 1840                 1845             


His Asn  Leu Val Gln Pro Arg  Asn Val Ser Asn Asn  Asp Thr Gly 
    1850                 1855                 1860             


Ser Gln  Met Ser Thr Tyr Lys  Ser His Tyr Tyr Thr  His Thr Pro 
    1865                 1870                 1875             


Ser Leu  Lys Thr Trp Ser Thr  Ile Lys 
    1880                 1885         


<210>  9
<211>  5679
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  CDS
<222>  (1)..(5679)
<223>  Candida albicans FKS1 (codon optimized)

<400>  9
atg agc tac aac gac aac aat aat cac tat tac gac ccg aat cag caa         48
Met Ser Tyr Asn Asp Asn Asn Asn His Tyr Tyr Asp Pro Asn Gln Gln           
1               5                   10                  15                

ggc gga atg ccc cct cat caa ggc gga gag ggg tat tac cag cag cag         96
Gly Gly Met Pro Pro His Gln Gly Gly Glu Gly Tyr Tyr Gln Gln Gln           
            20                  25                  30                    

tat gat gac atg ggc caa caa ccg cac caa cag gac tac tac gat ccg        144
Tyr Asp Asp Met Gly Gln Gln Pro His Gln Gln Asp Tyr Tyr Asp Pro           
        35                  40                  45                        

aat gct cag tat cag cag cag ccg tat gac atg gac ggt tat cag gac        192
Asn Ala Gln Tyr Gln Gln Gln Pro Tyr Asp Met Asp Gly Tyr Gln Asp           
    50                  55                  60                            

caa gcg aac tac ggc ggt cag ccg atg aat gcg caa ggc tac aac gcc        240
Gln Ala Asn Tyr Gly Gly Gln Pro Met Asn Ala Gln Gly Tyr Asn Ala           
65                  70                  75                  80            

gat ccc gag gcc ttt tcc gac ttc agc tac ggt ggc cag acc ccg ggt        288
Asp Pro Glu Ala Phe Ser Asp Phe Ser Tyr Gly Gly Gln Thr Pro Gly           
                85                  90                  95                

acc cca ggc tac gac cag tac ggt acc cag tac acc ccg agc cag atg        336
Thr Pro Gly Tyr Asp Gln Tyr Gly Thr Gln Tyr Thr Pro Ser Gln Met           
            100                 105                 110                   

tcc tat ggc ggc gac ccc cgg tcc tcg ggt gca agc act ccc att tat        384
Ser Tyr Gly Gly Asp Pro Arg Ser Ser Gly Ala Ser Thr Pro Ile Tyr           
        115                 120                 125                       

ggc ggc cag ggc cag ggt tac gac cct acc cag ttc aac atg tcc tcc        432
Gly Gly Gln Gly Gln Gly Tyr Asp Pro Thr Gln Phe Asn Met Ser Ser           
    130                 135                 140                           

aac ctc ccc tac ccc gcc tgg agc gcg gac ccc cag gcc ccg atc aag        480
Asn Leu Pro Tyr Pro Ala Trp Ser Ala Asp Pro Gln Ala Pro Ile Lys           
145                 150                 155                 160           

ata gag cat atc gaa gat atc ttc atc gac ctc acc aac aag ttc ggg        528
Ile Glu His Ile Glu Asp Ile Phe Ile Asp Leu Thr Asn Lys Phe Gly           
                165                 170                 175               

ttc cag cgg gac tcg atg cgc aat atg ttc gac tac ttc atg acg ctg        576
Phe Gln Arg Asp Ser Met Arg Asn Met Phe Asp Tyr Phe Met Thr Leu           
            180                 185                 190                   

ttg gat tcc cgc agc tcg cgc atg agc ccg gct cag gcc ctc ctc agc        624
Leu Asp Ser Arg Ser Ser Arg Met Ser Pro Ala Gln Ala Leu Leu Ser           
        195                 200                 205                       

ctg cat gcg gac tat att ggc ggg gat aac gcg aac tac cgg aaa tgg        672
Leu His Ala Asp Tyr Ile Gly Gly Asp Asn Ala Asn Tyr Arg Lys Trp           
    210                 215                 220                           

tac ttc agt tcg cag caa gat ctc gac gac tcg ctg ggc ttc gcg aac        720
Tyr Phe Ser Ser Gln Gln Asp Leu Asp Asp Ser Leu Gly Phe Ala Asn           
225                 230                 235                 240           

atg acc ctg ggg aag atc gga cgc aag gcc cgg aag gcc agc aag aaa        768
Met Thr Leu Gly Lys Ile Gly Arg Lys Ala Arg Lys Ala Ser Lys Lys           
                245                 250                 255               

tcc aag aag gcc cgc aaa gcg gcc gag gag cac ggc cag gac gtg gac        816
Ser Lys Lys Ala Arg Lys Ala Ala Glu Glu His Gly Gln Asp Val Asp           
            260                 265                 270                   

gcg aac gag ctg gaa ggc gac tat tcg ctt gag gcc gca gag atc cgc        864
Ala Asn Glu Leu Glu Gly Asp Tyr Ser Leu Glu Ala Ala Glu Ile Arg           
        275                 280                 285                       

tgg aag gcc aag atg aat tcg ctg acc ccg gaa gaa cgc gtg cgg gac        912
Trp Lys Ala Lys Met Asn Ser Leu Thr Pro Glu Glu Arg Val Arg Asp           
    290                 295                 300                           

ctg gcg ctg tat ctc ctg atc tgg ggc gaa gcg aat cag gtc agg ttt        960
Leu Ala Leu Tyr Leu Leu Ile Trp Gly Glu Ala Asn Gln Val Arg Phe           
305                 310                 315                 320           

acg ccc gag tgt ctc tgc tac atc tac aaa tcg gcc acc gat tat ctg       1008
Thr Pro Glu Cys Leu Cys Tyr Ile Tyr Lys Ser Ala Thr Asp Tyr Leu           
                325                 330                 335               

aat tcg ccc ctt tgc cag cag cgc cag gaa ccc gtc ccg gaa ggc gac       1056
Asn Ser Pro Leu Cys Gln Gln Arg Gln Glu Pro Val Pro Glu Gly Asp           
            340                 345                 350                   

tat ctg aac cgc gtg att acc ccc ctt tac cgc ttc atc cgg tcc caa       1104
Tyr Leu Asn Arg Val Ile Thr Pro Leu Tyr Arg Phe Ile Arg Ser Gln           
        355                 360                 365                       

gtc tat gag atc tac gac ggc cgg ttc gtc aag cgc gag aag gac cac       1152
Val Tyr Glu Ile Tyr Asp Gly Arg Phe Val Lys Arg Glu Lys Asp His           
    370                 375                 380                           

aat aag gtc att gga tac gac gac gtg aac caa ttg ttc tgg tat ccc       1200
Asn Lys Val Ile Gly Tyr Asp Asp Val Asn Gln Leu Phe Trp Tyr Pro           
385                 390                 395                 400           

gag ggc atc agc cgc atc atc ttc gag gat ggc acg cgc ctg gtg gac       1248
Glu Gly Ile Ser Arg Ile Ile Phe Glu Asp Gly Thr Arg Leu Val Asp           
                405                 410                 415               

atc ccg cag gag gag cgg ttc ttg aag ctc gga gag gtc gag tgg aaa       1296
Ile Pro Gln Glu Glu Arg Phe Leu Lys Leu Gly Glu Val Glu Trp Lys           
            420                 425                 430                   

aat gtg ttc ttc aag acc tat aaa gaa atc cgc acc tgg ctg cac ttc       1344
Asn Val Phe Phe Lys Thr Tyr Lys Glu Ile Arg Thr Trp Leu His Phe           
        435                 440                 445                       

gtg acc aat ttc aac cgg atc tgg atc atc cat ggc acg atc tat tgg       1392
Val Thr Asn Phe Asn Arg Ile Trp Ile Ile His Gly Thr Ile Tyr Trp           
    450                 455                 460                           

atg tat acg gcc tac aac tcg ccg acc ctg tat acc aag cat tat gtg       1440
Met Tyr Thr Ala Tyr Asn Ser Pro Thr Leu Tyr Thr Lys His Tyr Val           
465                 470                 475                 480           

cag acg atc aat cag cag ccg ctg gcc tcc agc cgc tgg gcc gcc tgc       1488
Gln Thr Ile Asn Gln Gln Pro Leu Ala Ser Ser Arg Trp Ala Ala Cys           
                485                 490                 495               

gcc att ggc ggc gtg ctc gcc tcc ttc atc caa att ctg gcc acc ctc       1536
Ala Ile Gly Gly Val Leu Ala Ser Phe Ile Gln Ile Leu Ala Thr Leu           
            500                 505                 510                   

ttc gag tgg att ttc gtt ccg cgg gag tgg gcg ggt gcg cag cat ctg       1584
Phe Glu Trp Ile Phe Val Pro Arg Glu Trp Ala Gly Ala Gln His Leu           
        515                 520                 525                       

tcg agg cgc atg ctg ttc ctg gtc ctc atc ttt ctg ctt aac ctg gtc       1632
Ser Arg Arg Met Leu Phe Leu Val Leu Ile Phe Leu Leu Asn Leu Val           
    530                 535                 540                           

cct ccg gtc tat acc ttc cag ata acc aag ctc gtc atc tac tcg aag       1680
Pro Pro Val Tyr Thr Phe Gln Ile Thr Lys Leu Val Ile Tyr Ser Lys           
545                 550                 555                 560           

agt gcg tac gct gtg tcc atc gtg ggc ttc ttc att gcc gtg gct acc       1728
Ser Ala Tyr Ala Val Ser Ile Val Gly Phe Phe Ile Ala Val Ala Thr           
                565                 570                 575               

ctg gtc ttt ttc gcg gtc atg ccg ctc ggg ggc ctc ttc acg tcc tat       1776
Leu Val Phe Phe Ala Val Met Pro Leu Gly Gly Leu Phe Thr Ser Tyr           
            580                 585                 590                   

atg aac aag cgg agt cgc cgg tat atc gcg agt cag acg ttc act gcg       1824
Met Asn Lys Arg Ser Arg Arg Tyr Ile Ala Ser Gln Thr Phe Thr Ala           
        595                 600                 605                       

aac tat atc aag ctc aag ggc ctc gac atg tgg atg agt tac ctc ctg       1872
Asn Tyr Ile Lys Leu Lys Gly Leu Asp Met Trp Met Ser Tyr Leu Leu           
    610                 615                 620                           

tgg ttc ctg gtt ttc ctc gcc aag ctc gtt gag tcc tac ttc ttc agc       1920
Trp Phe Leu Val Phe Leu Ala Lys Leu Val Glu Ser Tyr Phe Phe Ser           
625                 630                 635                 640           

acc ctg tcg ctg cgc gac ccc atc cgc aac ctg tcc acg atg acg atg       1968
Thr Leu Ser Leu Arg Asp Pro Ile Arg Asn Leu Ser Thr Met Thr Met           
                645                 650                 655               

cgc tgc gtc ggc gag gtc tgg tac aag gac atc gtg tgc cgc aac caa       2016
Arg Cys Val Gly Glu Val Trp Tyr Lys Asp Ile Val Cys Arg Asn Gln           
            660                 665                 670                   

gcc aag atc gtc ctc ggc ctc atg tat ctg gtc gat ctg ctc ctc ttc       2064
Ala Lys Ile Val Leu Gly Leu Met Tyr Leu Val Asp Leu Leu Leu Phe           
        675                 680                 685                       

ttc ctc gat acc tac atg tgg tac atc atc tgc aac tgc atc ttc tcc       2112
Phe Leu Asp Thr Tyr Met Trp Tyr Ile Ile Cys Asn Cys Ile Phe Ser           
    690                 695                 700                           

ata ggc cgc agc ttc tat ctg gga att agt atc ctc acc ccg tgg cgg       2160
Ile Gly Arg Ser Phe Tyr Leu Gly Ile Ser Ile Leu Thr Pro Trp Arg           
705                 710                 715                 720           

aac atc ttc acg cgc ctg ccg aag cgg att tac agc aag atc ttg gcg       2208
Asn Ile Phe Thr Arg Leu Pro Lys Arg Ile Tyr Ser Lys Ile Leu Ala           
                725                 730                 735               

acc acc gag atg gag atc aaa tac aaa ccc aag gtc ctt atc agc cag       2256
Thr Thr Glu Met Glu Ile Lys Tyr Lys Pro Lys Val Leu Ile Ser Gln           
            740                 745                 750                   

atc tgg aat gcg att gtt atc tcc atg tat cgc gag cat ctc ctg gcc       2304
Ile Trp Asn Ala Ile Val Ile Ser Met Tyr Arg Glu His Leu Leu Ala           
        755                 760                 765                       

atc gac cac gtc cag aaa ctg ctg tat cat caa gtg cca agc gag atc       2352
Ile Asp His Val Gln Lys Leu Leu Tyr His Gln Val Pro Ser Glu Ile           
    770                 775                 780                           

gaa ggc aag cgc acg ctg cgg gcg ccg acg ttc ttc gtg tcg caa gac       2400
Glu Gly Lys Arg Thr Leu Arg Ala Pro Thr Phe Phe Val Ser Gln Asp           
785                 790                 795                 800           

gac aat aat ttc gag act gag ttc ttc ccg cgc aac tcc gag gcc gag       2448
Asp Asn Asn Phe Glu Thr Glu Phe Phe Pro Arg Asn Ser Glu Ala Glu           
                805                 810                 815               

cgg cgc att agt ttc ttc gcc caa tcc ctt gcg acc ccg atg ccg gag       2496
Arg Arg Ile Ser Phe Phe Ala Gln Ser Leu Ala Thr Pro Met Pro Glu           
            820                 825                 830                   

ccc ctc ccg gtc gat aac atg ccc acg ttt acc gtg ttc acc cct cat       2544
Pro Leu Pro Val Asp Asn Met Pro Thr Phe Thr Val Phe Thr Pro His           
        835                 840                 845                       

tac agc gag aag atc ctg ctc agc ctg cgc gag atc att cgc gag gac       2592
Tyr Ser Glu Lys Ile Leu Leu Ser Leu Arg Glu Ile Ile Arg Glu Asp           
    850                 855                 860                           

gac caa ttc tcg cgc gtc acg ctg ctg gag tat ctc aag cag ctg cat       2640
Asp Gln Phe Ser Arg Val Thr Leu Leu Glu Tyr Leu Lys Gln Leu His           
865                 870                 875                 880           

ccg gtc gag tgg gac tgc ttc gtt aag gac acg aag atc ctc gcc gaa       2688
Pro Val Glu Trp Asp Cys Phe Val Lys Asp Thr Lys Ile Leu Ala Glu           
                885                 890                 895               

gaa acc gct gcc tac gag aac ggc gac gac tcg gag aaa ttg tcc gag       2736
Glu Thr Ala Ala Tyr Glu Asn Gly Asp Asp Ser Glu Lys Leu Ser Glu           
            900                 905                 910                   

gac ggc ctc aag tcg aag atc gat gac ctc cca ttc tac tgc atc ggc       2784
Asp Gly Leu Lys Ser Lys Ile Asp Asp Leu Pro Phe Tyr Cys Ile Gly           
        915                 920                 925                       

ttc aaa tcc gca gca ccc gag tat acg ctc cgg acg cgc atc tgg gcg       2832
Phe Lys Ser Ala Ala Pro Glu Tyr Thr Leu Arg Thr Arg Ile Trp Ala           
    930                 935                 940                           

agc ctg cgc agc caa acc ttg tac cgg acg gtc agc ggc ttc atg aat       2880
Ser Leu Arg Ser Gln Thr Leu Tyr Arg Thr Val Ser Gly Phe Met Asn           
945                 950                 955                 960           

tac gcc cgc gcg ata aaa ctg ctc tat agg gtc gag aac ccg gag ctc       2928
Tyr Ala Arg Ala Ile Lys Leu Leu Tyr Arg Val Glu Asn Pro Glu Leu           
                965                 970                 975               

gtc cag tat ttt ggc ggc gac ccc gag ggc ctg gag ctg gcg ctg gag       2976
Val Gln Tyr Phe Gly Gly Asp Pro Glu Gly Leu Glu Leu Ala Leu Glu           
            980                 985                 990                   

cgc atg gcg cgc cgc aaa ttc cgc  ttc ctc gtg agc atg  cag cgc ctg     3024
Arg Met Ala Arg Arg Lys Phe Arg  Phe Leu Val Ser Met  Gln Arg Leu         
        995                 1000                 1005                     

tcg aag  ttc aaa gac gat gag  atg gag aat gct gaa  ttc ctc ctg        3069
Ser Lys  Phe Lys Asp Asp Glu  Met Glu Asn Ala Glu  Phe Leu Leu            
    1010                 1015                 1020                        

cgg gcc  tac ccg gac ctc cag  atc gcg tat ctc gac  gaa gaa ccg        3114
Arg Ala  Tyr Pro Asp Leu Gln  Ile Ala Tyr Leu Asp  Glu Glu Pro            
    1025                 1030                 1035                        

gcg ctg  aat gag gac gag gaa  ccg cgc gtg tac agc  gca ctg atc        3159
Ala Leu  Asn Glu Asp Glu Glu  Pro Arg Val Tyr Ser  Ala Leu Ile            
    1040                 1045                 1050                        

gac gga  cac tgc gag atg ctg  gag aac ggc agg cgc  agg ccg aag        3204
Asp Gly  His Cys Glu Met Leu  Glu Asn Gly Arg Arg  Arg Pro Lys            
    1055                 1060                 1065                        

ttt cgc  gtc cag ttg tcg ggc  aac ccg atc ctc ggc  gat ggt aag        3249
Phe Arg  Val Gln Leu Ser Gly  Asn Pro Ile Leu Gly  Asp Gly Lys            
    1070                 1075                 1080                        

tcc gac  aac cag aat cac gcc  gtc atc ttc cat cgc  ggc gag tat        3294
Ser Asp  Asn Gln Asn His Ala  Val Ile Phe His Arg  Gly Glu Tyr            
    1085                 1090                 1095                        

atc cag  ctg atc gac gcg aac  cag gac aac tat ctg  gaa gag tgc        3339
Ile Gln  Leu Ile Asp Ala Asn  Gln Asp Asn Tyr Leu  Glu Glu Cys            
    1100                 1105                 1110                        

ctg aag  atc cgc tcg gtc ctg  gct gaa ttc gaa gag  atg aac gtc        3384
Leu Lys  Ile Arg Ser Val Leu  Ala Glu Phe Glu Glu  Met Asn Val            
    1115                 1120                 1125                        

gag cat  gtt aat ccg tac gcc  ccg aat ttg aaa tcc  gag gac aac        3429
Glu His  Val Asn Pro Tyr Ala  Pro Asn Leu Lys Ser  Glu Asp Asn            
    1130                 1135                 1140                        

aac acg  aag aaa gac ccg gtc  gcc ttc ctg ggc gca  cgc gag tac        3474
Asn Thr  Lys Lys Asp Pro Val  Ala Phe Leu Gly Ala  Arg Glu Tyr            
    1145                 1150                 1155                        

atc ttc  agt gag aac tcg ggc  gtg ctg ggc gac gtg  gct gcg ggc        3519
Ile Phe  Ser Glu Asn Ser Gly  Val Leu Gly Asp Val  Ala Ala Gly            
    1160                 1165                 1170                        

aaa gag  cag acg ttt ggc acc  ctg ttc gcc cgg acc  ctc gcg cag        3564
Lys Glu  Gln Thr Phe Gly Thr  Leu Phe Ala Arg Thr  Leu Ala Gln            
    1175                 1180                 1185                        

atc ggc  ggg aag ctc cac tat  ggc cat ccc gac ttc  ctg aat gcg        3609
Ile Gly  Gly Lys Leu His Tyr  Gly His Pro Asp Phe  Leu Asn Ala            
    1190                 1195                 1200                        

acg ttc  atg ctc acg cgc ggg  ggc gtg tcc aaa gcc  cag aag ggc        3654
Thr Phe  Met Leu Thr Arg Gly  Gly Val Ser Lys Ala  Gln Lys Gly            
    1205                 1210                 1215                        

ctg cac  ctc aac gaa gat atc  tat gcg ggt atg aat  gcg atg atg        3699
Leu His  Leu Asn Glu Asp Ile  Tyr Ala Gly Met Asn  Ala Met Met            
    1220                 1225                 1230                        

cgg ggt  ggc aag atc aag cac  tgc gag tac tac cag  tgc ggt aag        3744
Arg Gly  Gly Lys Ile Lys His  Cys Glu Tyr Tyr Gln  Cys Gly Lys            
    1235                 1240                 1245                        

ggc agg  gat ctt ggc ttc ggc  tcc atc ctc aac ttc  acc acc aag        3789
Gly Arg  Asp Leu Gly Phe Gly  Ser Ile Leu Asn Phe  Thr Thr Lys            
    1250                 1255                 1260                        

atc ggg  gcc ggc atg ggc gag  caa atg ctc tcg cgg  gag tac ttt        3834
Ile Gly  Ala Gly Met Gly Glu  Gln Met Leu Ser Arg  Glu Tyr Phe            
    1265                 1270                 1275                        

tat ctg  ggt acc cag ctt ccc  ctt gac cgc ttc ctc  tcg ttc tac        3879
Tyr Leu  Gly Thr Gln Leu Pro  Leu Asp Arg Phe Leu  Ser Phe Tyr            
    1280                 1285                 1290                        

tac ggg  cat ccg gga ttc cac  atc aac aac ctc ttc  atc caa ctg        3924
Tyr Gly  His Pro Gly Phe His  Ile Asn Asn Leu Phe  Ile Gln Leu            
    1295                 1300                 1305                        

agc ctc  caa gtg ttc atc ctt  gtg ctt ggc aat ctg  aat tcg ctg        3969
Ser Leu  Gln Val Phe Ile Leu  Val Leu Gly Asn Leu  Asn Ser Leu            
    1310                 1315                 1320                        

gcc cac  gag gcc atc atg tgt  tcg tac aac aaa gac  gtg ccc gtc        4014
Ala His  Glu Ala Ile Met Cys  Ser Tyr Asn Lys Asp  Val Pro Val            
    1325                 1330                 1335                        

act gac  gtg ctc tac ccc ttc  ggc tgt tac aat atc  gct ccc gcg        4059
Thr Asp  Val Leu Tyr Pro Phe  Gly Cys Tyr Asn Ile  Ala Pro Ala            
    1340                 1345                 1350                        

gtg gat  tgg atc cgc cgg tat  acc ctc tcg atc ttc  att gtc ttt        4104
Val Asp  Trp Ile Arg Arg Tyr  Thr Leu Ser Ile Phe  Ile Val Phe            
    1355                 1360                 1365                        

ttc atc  tcg ttc atc ccg ctg  gtc gtc cag gag ctc  ata gag cgg        4149
Phe Ile  Ser Phe Ile Pro Leu  Val Val Gln Glu Leu  Ile Glu Arg            
    1370                 1375                 1380                        

gga gtg  tgg aag gct ttc cag  cgg ttc gtc cgg cat  ttc atc tcg        4194
Gly Val  Trp Lys Ala Phe Gln  Arg Phe Val Arg His  Phe Ile Ser            
    1385                 1390                 1395                        

atg tcc  ccg ttc ttc gag gtg  ttc gtg gcg cag ata  tat tcg agc        4239
Met Ser  Pro Phe Phe Glu Val  Phe Val Ala Gln Ile  Tyr Ser Ser            
    1400                 1405                 1410                        

tcc gtg  ttc acg gac ctc acc  gtg ggt ggg gcg agg  tat atc agc        4284
Ser Val  Phe Thr Asp Leu Thr  Val Gly Gly Ala Arg  Tyr Ile Ser            
    1415                 1420                 1425                        

acc ggg  cgc ggg ttc gcc acc  tcg cgc atc ccg ttt  tcg atc aag        4329
Thr Gly  Arg Gly Phe Ala Thr  Ser Arg Ile Pro Phe  Ser Ile Lys            
    1430                 1435                 1440                        

cgc ttt  gcg gat tcg agt atc  tat atg ggc gct cgg  ctc atg ctc        4374
Arg Phe  Ala Asp Ser Ser Ile  Tyr Met Gly Ala Arg  Leu Met Leu            
    1445                 1450                 1455                        

atc ctg  ctt ttc ggt acc gtg  agc cac tgg caa gcg  ccg ctt ctc        4419
Ile Leu  Leu Phe Gly Thr Val  Ser His Trp Gln Ala  Pro Leu Leu            
    1460                 1465                 1470                        

tgg ttc  tgg gcc tcg ctc tcc  gcg ttg atg ttc tcc  ccg ttc atc        4464
Trp Phe  Trp Ala Ser Leu Ser  Ala Leu Met Phe Ser  Pro Phe Ile            
    1475                 1480                 1485                        

ttt aac  ccg cat cag ttc gcg  tgg gaa gat ttc ttt  ctc gac tat        4509
Phe Asn  Pro His Gln Phe Ala  Trp Glu Asp Phe Phe  Leu Asp Tyr            
    1490                 1495                 1500                        

cgc gat  ttc atc cgc tgg ctg  tcc cgc gga aac acc  aag tgg cat        4554
Arg Asp  Phe Ile Arg Trp Leu  Ser Arg Gly Asn Thr  Lys Trp His            
    1505                 1510                 1515                        

cgg aac  agc tgg atc ggc tac  gtt cgc ctc tcg cgg  tcg cgc ata        4599
Arg Asn  Ser Trp Ile Gly Tyr  Val Arg Leu Ser Arg  Ser Arg Ile            
    1520                 1525                 1530                        

acg ggc  ttc aag cgg aaa ctc  acc ggc gac gtg agc  gag aaa gcc        4644
Thr Gly  Phe Lys Arg Lys Leu  Thr Gly Asp Val Ser  Glu Lys Ala            
    1535                 1540                 1545                        

gct ggc  gat gcc tcc agg gct  cat cgc tcg aat gtg  ctg ttc gcg        4689
Ala Gly  Asp Ala Ser Arg Ala  His Arg Ser Asn Val  Leu Phe Ala            
    1550                 1555                 1560                        

gac ttc  ctg ccg acc ctg ata  tac act gcg ggc ctc  tac gtc gcc        4734
Asp Phe  Leu Pro Thr Leu Ile  Tyr Thr Ala Gly Leu  Tyr Val Ala            
    1565                 1570                 1575                        

tat acc  ttc atc aac gcc cag  acg ggc gtc acc agc  tat ccc tac        4779
Tyr Thr  Phe Ile Asn Ala Gln  Thr Gly Val Thr Ser  Tyr Pro Tyr            
    1580                 1585                 1590                        

gag atc  aat ggc tcg acg gac  ccg caa cca gtt aac  tcc acg ctg        4824
Glu Ile  Asn Gly Ser Thr Asp  Pro Gln Pro Val Asn  Ser Thr Leu            
    1595                 1600                 1605                        

agg ctc  atc atc tgc gcc ctg  gca cct gtc gtc atc  gac atg ggc        4869
Arg Leu  Ile Ile Cys Ala Leu  Ala Pro Val Val Ile  Asp Met Gly            
    1610                 1615                 1620                        

tgc ctg  ggt gtg tgc ctc gcc  atg gcg tgc tgc gcc  ggc ccg atg        4914
Cys Leu  Gly Val Cys Leu Ala  Met Ala Cys Cys Ala  Gly Pro Met            
    1625                 1630                 1635                        

ctg ggc  ctg tgc tgc aag aaa  acc ggc gca gtc atc  gcc ggt gtc        4959
Leu Gly  Leu Cys Cys Lys Lys  Thr Gly Ala Val Ile  Ala Gly Val            
    1640                 1645                 1650                        

gcg cac  ggc gtc gcc gtc atc  gtc cat atc atc ttc  ttc atc gtg        5004
Ala His  Gly Val Ala Val Ile  Val His Ile Ile Phe  Phe Ile Val            
    1655                 1660                 1665                        

atg tgg  gtg act gag ggt ttc  aat ttc gca cgc ctg  atg ctt ggc        5049
Met Trp  Val Thr Glu Gly Phe  Asn Phe Ala Arg Leu  Met Leu Gly            
    1670                 1675                 1680                        

atc gcg  acc atg atc tat gtg  cag agg ctg ctt ttc  aag ttc ctg        5094
Ile Ala  Thr Met Ile Tyr Val  Gln Arg Leu Leu Phe  Lys Phe Leu            
    1685                 1690                 1695                        

acg ctg  tgc ttc ctc acc cgg  gag ttc aag aac gac  aaa gcc aac        5139
Thr Leu  Cys Phe Leu Thr Arg  Glu Phe Lys Asn Asp  Lys Ala Asn            
    1700                 1705                 1710                        

acc gcg  ttt tgg acg ggt aag  tgg tat aac acc ggc  atg ggc tgg        5184
Thr Ala  Phe Trp Thr Gly Lys  Trp Tyr Asn Thr Gly  Met Gly Trp            
    1715                 1720                 1725                        

atg gcc  ttc acg cag ccg agc  cgc gag ttc gtg gcc  aag atc atc        5229
Met Ala  Phe Thr Gln Pro Ser  Arg Glu Phe Val Ala  Lys Ile Ile            
    1730                 1735                 1740                        

gag atg  agc gag ttc gcg ggt  gat ttc gtc ctt gcc  cac ata atc        5274
Glu Met  Ser Glu Phe Ala Gly  Asp Phe Val Leu Ala  His Ile Ile            
    1745                 1750                 1755                        

ctg ttc  tgc cag ctg ccg ctc  ctg ttc att ccg ttg  gtc gac cgc        5319
Leu Phe  Cys Gln Leu Pro Leu  Leu Phe Ile Pro Leu  Val Asp Arg            
    1760                 1765                 1770                        

tgg cat  agc atg atg ctg ttc  tgg ctg aag ccg tcc  cgc ctc att        5364
Trp His  Ser Met Met Leu Phe  Trp Leu Lys Pro Ser  Arg Leu Ile            
    1775                 1780                 1785                        

cgg cca  cct atc tac tcg ctc  aaa caa gcg cgc ctg  cgc aag cgg        5409
Arg Pro  Pro Ile Tyr Ser Leu  Lys Gln Ala Arg Leu  Arg Lys Arg            
    1790                 1795                 1800                        

atg gtc  cgc aaa tac tgt gtc  ctg tat ttc gca gtg  ctt atc ctg        5454
Met Val  Arg Lys Tyr Cys Val  Leu Tyr Phe Ala Val  Leu Ile Leu            
    1805                 1810                 1815                        

ttc atc  gtt atc atc gtc gcg  cct gcg gtc gca tcg  ggg cag atc        5499
Phe Ile  Val Ile Ile Val Ala  Pro Ala Val Ala Ser  Gly Gln Ile            
    1820                 1825                 1830                        

gcg gtg  gac cag ttc gcc aac  att ggc ggc agc ggc  tcc ata gca        5544
Ala Val  Asp Gln Phe Ala Asn  Ile Gly Gly Ser Gly  Ser Ile Ala            
    1835                 1840                 1845                        

gac ggc  ttg ttc caa ccc cgg  aat gtg agc aac aac  gac acc ggg        5589
Asp Gly  Leu Phe Gln Pro Arg  Asn Val Ser Asn Asn  Asp Thr Gly            
    1850                 1855                 1860                        

aat cat  cgc cca aag acc tac  acc tgg tcc tac ctc  tcg acc cgc        5634
Asn His  Arg Pro Lys Thr Tyr  Thr Trp Ser Tyr Leu  Ser Thr Arg            
    1865                 1870                 1875                        

ttc acc  ggc tcg acc acc ccc  tac tcc acc aat ccc  ttc agg gtg        5679
Phe Thr  Gly Ser Thr Thr Pro  Tyr Ser Thr Asn Pro  Phe Arg Val            
    1880                 1885                 1890                        


<210>  10
<211>  1893
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  10

Met Ser Tyr Asn Asp Asn Asn Asn His Tyr Tyr Asp Pro Asn Gln Gln 
1               5                   10                  15      


Gly Gly Met Pro Pro His Gln Gly Gly Glu Gly Tyr Tyr Gln Gln Gln 
            20                  25                  30          


Tyr Asp Asp Met Gly Gln Gln Pro His Gln Gln Asp Tyr Tyr Asp Pro 
        35                  40                  45              


Asn Ala Gln Tyr Gln Gln Gln Pro Tyr Asp Met Asp Gly Tyr Gln Asp 
    50                  55                  60                  


Gln Ala Asn Tyr Gly Gly Gln Pro Met Asn Ala Gln Gly Tyr Asn Ala 
65                  70                  75                  80  


Asp Pro Glu Ala Phe Ser Asp Phe Ser Tyr Gly Gly Gln Thr Pro Gly 
                85                  90                  95      


Thr Pro Gly Tyr Asp Gln Tyr Gly Thr Gln Tyr Thr Pro Ser Gln Met 
            100                 105                 110         


Ser Tyr Gly Gly Asp Pro Arg Ser Ser Gly Ala Ser Thr Pro Ile Tyr 
        115                 120                 125             


Gly Gly Gln Gly Gln Gly Tyr Asp Pro Thr Gln Phe Asn Met Ser Ser 
    130                 135                 140                 


Asn Leu Pro Tyr Pro Ala Trp Ser Ala Asp Pro Gln Ala Pro Ile Lys 
145                 150                 155                 160 


Ile Glu His Ile Glu Asp Ile Phe Ile Asp Leu Thr Asn Lys Phe Gly 
                165                 170                 175     


Phe Gln Arg Asp Ser Met Arg Asn Met Phe Asp Tyr Phe Met Thr Leu 
            180                 185                 190         


Leu Asp Ser Arg Ser Ser Arg Met Ser Pro Ala Gln Ala Leu Leu Ser 
        195                 200                 205             


Leu His Ala Asp Tyr Ile Gly Gly Asp Asn Ala Asn Tyr Arg Lys Trp 
    210                 215                 220                 


Tyr Phe Ser Ser Gln Gln Asp Leu Asp Asp Ser Leu Gly Phe Ala Asn 
225                 230                 235                 240 


Met Thr Leu Gly Lys Ile Gly Arg Lys Ala Arg Lys Ala Ser Lys Lys 
                245                 250                 255     


Ser Lys Lys Ala Arg Lys Ala Ala Glu Glu His Gly Gln Asp Val Asp 
            260                 265                 270         


Ala Asn Glu Leu Glu Gly Asp Tyr Ser Leu Glu Ala Ala Glu Ile Arg 
        275                 280                 285             


Trp Lys Ala Lys Met Asn Ser Leu Thr Pro Glu Glu Arg Val Arg Asp 
    290                 295                 300                 


Leu Ala Leu Tyr Leu Leu Ile Trp Gly Glu Ala Asn Gln Val Arg Phe 
305                 310                 315                 320 


Thr Pro Glu Cys Leu Cys Tyr Ile Tyr Lys Ser Ala Thr Asp Tyr Leu 
                325                 330                 335     


Asn Ser Pro Leu Cys Gln Gln Arg Gln Glu Pro Val Pro Glu Gly Asp 
            340                 345                 350         


Tyr Leu Asn Arg Val Ile Thr Pro Leu Tyr Arg Phe Ile Arg Ser Gln 
        355                 360                 365             


Val Tyr Glu Ile Tyr Asp Gly Arg Phe Val Lys Arg Glu Lys Asp His 
    370                 375                 380                 


Asn Lys Val Ile Gly Tyr Asp Asp Val Asn Gln Leu Phe Trp Tyr Pro 
385                 390                 395                 400 


Glu Gly Ile Ser Arg Ile Ile Phe Glu Asp Gly Thr Arg Leu Val Asp 
                405                 410                 415     


Ile Pro Gln Glu Glu Arg Phe Leu Lys Leu Gly Glu Val Glu Trp Lys 
            420                 425                 430         


Asn Val Phe Phe Lys Thr Tyr Lys Glu Ile Arg Thr Trp Leu His Phe 
        435                 440                 445             


Val Thr Asn Phe Asn Arg Ile Trp Ile Ile His Gly Thr Ile Tyr Trp 
    450                 455                 460                 


Met Tyr Thr Ala Tyr Asn Ser Pro Thr Leu Tyr Thr Lys His Tyr Val 
465                 470                 475                 480 


Gln Thr Ile Asn Gln Gln Pro Leu Ala Ser Ser Arg Trp Ala Ala Cys 
                485                 490                 495     


Ala Ile Gly Gly Val Leu Ala Ser Phe Ile Gln Ile Leu Ala Thr Leu 
            500                 505                 510         


Phe Glu Trp Ile Phe Val Pro Arg Glu Trp Ala Gly Ala Gln His Leu 
        515                 520                 525             


Ser Arg Arg Met Leu Phe Leu Val Leu Ile Phe Leu Leu Asn Leu Val 
    530                 535                 540                 


Pro Pro Val Tyr Thr Phe Gln Ile Thr Lys Leu Val Ile Tyr Ser Lys 
545                 550                 555                 560 


Ser Ala Tyr Ala Val Ser Ile Val Gly Phe Phe Ile Ala Val Ala Thr 
                565                 570                 575     


Leu Val Phe Phe Ala Val Met Pro Leu Gly Gly Leu Phe Thr Ser Tyr 
            580                 585                 590         


Met Asn Lys Arg Ser Arg Arg Tyr Ile Ala Ser Gln Thr Phe Thr Ala 
        595                 600                 605             


Asn Tyr Ile Lys Leu Lys Gly Leu Asp Met Trp Met Ser Tyr Leu Leu 
    610                 615                 620                 


Trp Phe Leu Val Phe Leu Ala Lys Leu Val Glu Ser Tyr Phe Phe Ser 
625                 630                 635                 640 


Thr Leu Ser Leu Arg Asp Pro Ile Arg Asn Leu Ser Thr Met Thr Met 
                645                 650                 655     


Arg Cys Val Gly Glu Val Trp Tyr Lys Asp Ile Val Cys Arg Asn Gln 
            660                 665                 670         


Ala Lys Ile Val Leu Gly Leu Met Tyr Leu Val Asp Leu Leu Leu Phe 
        675                 680                 685             


Phe Leu Asp Thr Tyr Met Trp Tyr Ile Ile Cys Asn Cys Ile Phe Ser 
    690                 695                 700                 


Ile Gly Arg Ser Phe Tyr Leu Gly Ile Ser Ile Leu Thr Pro Trp Arg 
705                 710                 715                 720 


Asn Ile Phe Thr Arg Leu Pro Lys Arg Ile Tyr Ser Lys Ile Leu Ala 
                725                 730                 735     


Thr Thr Glu Met Glu Ile Lys Tyr Lys Pro Lys Val Leu Ile Ser Gln 
            740                 745                 750         


Ile Trp Asn Ala Ile Val Ile Ser Met Tyr Arg Glu His Leu Leu Ala 
        755                 760                 765             


Ile Asp His Val Gln Lys Leu Leu Tyr His Gln Val Pro Ser Glu Ile 
    770                 775                 780                 


Glu Gly Lys Arg Thr Leu Arg Ala Pro Thr Phe Phe Val Ser Gln Asp 
785                 790                 795                 800 


Asp Asn Asn Phe Glu Thr Glu Phe Phe Pro Arg Asn Ser Glu Ala Glu 
                805                 810                 815     


Arg Arg Ile Ser Phe Phe Ala Gln Ser Leu Ala Thr Pro Met Pro Glu 
            820                 825                 830         


Pro Leu Pro Val Asp Asn Met Pro Thr Phe Thr Val Phe Thr Pro His 
        835                 840                 845             


Tyr Ser Glu Lys Ile Leu Leu Ser Leu Arg Glu Ile Ile Arg Glu Asp 
    850                 855                 860                 


Asp Gln Phe Ser Arg Val Thr Leu Leu Glu Tyr Leu Lys Gln Leu His 
865                 870                 875                 880 


Pro Val Glu Trp Asp Cys Phe Val Lys Asp Thr Lys Ile Leu Ala Glu 
                885                 890                 895     


Glu Thr Ala Ala Tyr Glu Asn Gly Asp Asp Ser Glu Lys Leu Ser Glu 
            900                 905                 910         


Asp Gly Leu Lys Ser Lys Ile Asp Asp Leu Pro Phe Tyr Cys Ile Gly 
        915                 920                 925             


Phe Lys Ser Ala Ala Pro Glu Tyr Thr Leu Arg Thr Arg Ile Trp Ala 
    930                 935                 940                 


Ser Leu Arg Ser Gln Thr Leu Tyr Arg Thr Val Ser Gly Phe Met Asn 
945                 950                 955                 960 


Tyr Ala Arg Ala Ile Lys Leu Leu Tyr Arg Val Glu Asn Pro Glu Leu 
                965                 970                 975     


Val Gln Tyr Phe Gly Gly Asp Pro Glu Gly Leu Glu Leu Ala Leu Glu 
            980                 985                 990         


Arg Met Ala Arg Arg Lys Phe Arg  Phe Leu Val Ser Met  Gln Arg Leu 
        995                 1000                 1005             


Ser Lys  Phe Lys Asp Asp Glu  Met Glu Asn Ala Glu  Phe Leu Leu 
    1010                 1015                 1020             


Arg Ala  Tyr Pro Asp Leu Gln  Ile Ala Tyr Leu Asp  Glu Glu Pro 
    1025                 1030                 1035             


Ala Leu  Asn Glu Asp Glu Glu  Pro Arg Val Tyr Ser  Ala Leu Ile 
    1040                 1045                 1050             


Asp Gly  His Cys Glu Met Leu  Glu Asn Gly Arg Arg  Arg Pro Lys 
    1055                 1060                 1065             


Phe Arg  Val Gln Leu Ser Gly  Asn Pro Ile Leu Gly  Asp Gly Lys 
    1070                 1075                 1080             


Ser Asp  Asn Gln Asn His Ala  Val Ile Phe His Arg  Gly Glu Tyr 
    1085                 1090                 1095             


Ile Gln  Leu Ile Asp Ala Asn  Gln Asp Asn Tyr Leu  Glu Glu Cys 
    1100                 1105                 1110             


Leu Lys  Ile Arg Ser Val Leu  Ala Glu Phe Glu Glu  Met Asn Val 
    1115                 1120                 1125             


Glu His  Val Asn Pro Tyr Ala  Pro Asn Leu Lys Ser  Glu Asp Asn 
    1130                 1135                 1140             


Asn Thr  Lys Lys Asp Pro Val  Ala Phe Leu Gly Ala  Arg Glu Tyr 
    1145                 1150                 1155             


Ile Phe  Ser Glu Asn Ser Gly  Val Leu Gly Asp Val  Ala Ala Gly 
    1160                 1165                 1170             


Lys Glu  Gln Thr Phe Gly Thr  Leu Phe Ala Arg Thr  Leu Ala Gln 
    1175                 1180                 1185             


Ile Gly  Gly Lys Leu His Tyr  Gly His Pro Asp Phe  Leu Asn Ala 
    1190                 1195                 1200             


Thr Phe  Met Leu Thr Arg Gly  Gly Val Ser Lys Ala  Gln Lys Gly 
    1205                 1210                 1215             


Leu His  Leu Asn Glu Asp Ile  Tyr Ala Gly Met Asn  Ala Met Met 
    1220                 1225                 1230             


Arg Gly  Gly Lys Ile Lys His  Cys Glu Tyr Tyr Gln  Cys Gly Lys 
    1235                 1240                 1245             


Gly Arg  Asp Leu Gly Phe Gly  Ser Ile Leu Asn Phe  Thr Thr Lys 
    1250                 1255                 1260             


Ile Gly  Ala Gly Met Gly Glu  Gln Met Leu Ser Arg  Glu Tyr Phe 
    1265                 1270                 1275             


Tyr Leu  Gly Thr Gln Leu Pro  Leu Asp Arg Phe Leu  Ser Phe Tyr 
    1280                 1285                 1290             


Tyr Gly  His Pro Gly Phe His  Ile Asn Asn Leu Phe  Ile Gln Leu 
    1295                 1300                 1305             


Ser Leu  Gln Val Phe Ile Leu  Val Leu Gly Asn Leu  Asn Ser Leu 
    1310                 1315                 1320             


Ala His  Glu Ala Ile Met Cys  Ser Tyr Asn Lys Asp  Val Pro Val 
    1325                 1330                 1335             


Thr Asp  Val Leu Tyr Pro Phe  Gly Cys Tyr Asn Ile  Ala Pro Ala 
    1340                 1345                 1350             


Val Asp  Trp Ile Arg Arg Tyr  Thr Leu Ser Ile Phe  Ile Val Phe 
    1355                 1360                 1365             


Phe Ile  Ser Phe Ile Pro Leu  Val Val Gln Glu Leu  Ile Glu Arg 
    1370                 1375                 1380             


Gly Val  Trp Lys Ala Phe Gln  Arg Phe Val Arg His  Phe Ile Ser 
    1385                 1390                 1395             


Met Ser  Pro Phe Phe Glu Val  Phe Val Ala Gln Ile  Tyr Ser Ser 
    1400                 1405                 1410             


Ser Val  Phe Thr Asp Leu Thr  Val Gly Gly Ala Arg  Tyr Ile Ser 
    1415                 1420                 1425             


Thr Gly  Arg Gly Phe Ala Thr  Ser Arg Ile Pro Phe  Ser Ile Lys 
    1430                 1435                 1440             


Arg Phe  Ala Asp Ser Ser Ile  Tyr Met Gly Ala Arg  Leu Met Leu 
    1445                 1450                 1455             


Ile Leu  Leu Phe Gly Thr Val  Ser His Trp Gln Ala  Pro Leu Leu 
    1460                 1465                 1470             


Trp Phe  Trp Ala Ser Leu Ser  Ala Leu Met Phe Ser  Pro Phe Ile 
    1475                 1480                 1485             


Phe Asn  Pro His Gln Phe Ala  Trp Glu Asp Phe Phe  Leu Asp Tyr 
    1490                 1495                 1500             


Arg Asp  Phe Ile Arg Trp Leu  Ser Arg Gly Asn Thr  Lys Trp His 
    1505                 1510                 1515             


Arg Asn  Ser Trp Ile Gly Tyr  Val Arg Leu Ser Arg  Ser Arg Ile 
    1520                 1525                 1530             


Thr Gly  Phe Lys Arg Lys Leu  Thr Gly Asp Val Ser  Glu Lys Ala 
    1535                 1540                 1545             


Ala Gly  Asp Ala Ser Arg Ala  His Arg Ser Asn Val  Leu Phe Ala 
    1550                 1555                 1560             


Asp Phe  Leu Pro Thr Leu Ile  Tyr Thr Ala Gly Leu  Tyr Val Ala 
    1565                 1570                 1575             


Tyr Thr  Phe Ile Asn Ala Gln  Thr Gly Val Thr Ser  Tyr Pro Tyr 
    1580                 1585                 1590             


Glu Ile  Asn Gly Ser Thr Asp  Pro Gln Pro Val Asn  Ser Thr Leu 
    1595                 1600                 1605             


Arg Leu  Ile Ile Cys Ala Leu  Ala Pro Val Val Ile  Asp Met Gly 
    1610                 1615                 1620             


Cys Leu  Gly Val Cys Leu Ala  Met Ala Cys Cys Ala  Gly Pro Met 
    1625                 1630                 1635             


Leu Gly  Leu Cys Cys Lys Lys  Thr Gly Ala Val Ile  Ala Gly Val 
    1640                 1645                 1650             


Ala His  Gly Val Ala Val Ile  Val His Ile Ile Phe  Phe Ile Val 
    1655                 1660                 1665             


Met Trp  Val Thr Glu Gly Phe  Asn Phe Ala Arg Leu  Met Leu Gly 
    1670                 1675                 1680             


Ile Ala  Thr Met Ile Tyr Val  Gln Arg Leu Leu Phe  Lys Phe Leu 
    1685                 1690                 1695             


Thr Leu  Cys Phe Leu Thr Arg  Glu Phe Lys Asn Asp  Lys Ala Asn 
    1700                 1705                 1710             


Thr Ala  Phe Trp Thr Gly Lys  Trp Tyr Asn Thr Gly  Met Gly Trp 
    1715                 1720                 1725             


Met Ala  Phe Thr Gln Pro Ser  Arg Glu Phe Val Ala  Lys Ile Ile 
    1730                 1735                 1740             


Glu Met  Ser Glu Phe Ala Gly  Asp Phe Val Leu Ala  His Ile Ile 
    1745                 1750                 1755             


Leu Phe  Cys Gln Leu Pro Leu  Leu Phe Ile Pro Leu  Val Asp Arg 
    1760                 1765                 1770             


Trp His  Ser Met Met Leu Phe  Trp Leu Lys Pro Ser  Arg Leu Ile 
    1775                 1780                 1785             


Arg Pro  Pro Ile Tyr Ser Leu  Lys Gln Ala Arg Leu  Arg Lys Arg 
    1790                 1795                 1800             


Met Val  Arg Lys Tyr Cys Val  Leu Tyr Phe Ala Val  Leu Ile Leu 
    1805                 1810                 1815             


Phe Ile  Val Ile Ile Val Ala  Pro Ala Val Ala Ser  Gly Gln Ile 
    1820                 1825                 1830             


Ala Val  Asp Gln Phe Ala Asn  Ile Gly Gly Ser Gly  Ser Ile Ala 
    1835                 1840                 1845             


Asp Gly  Leu Phe Gln Pro Arg  Asn Val Ser Asn Asn  Asp Thr Gly 
    1850                 1855                 1860             


Asn His  Arg Pro Lys Thr Tyr  Thr Trp Ser Tyr Leu  Ser Thr Arg 
    1865                 1870                 1875             


Phe Thr  Gly Ser Thr Thr Pro  Tyr Ser Thr Asn Pro  Phe Arg Val 
    1880                 1885                 1890             


<210>  11
<211>  171
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  CDS
<222>  (1)..(171)
<223>  Zea mays (corn)  portion of 1,3-D-glucan synthase (codon 
       optimized)

<400>  11
ttc aac tgt acc ctc cgc ggc ggc aat gtt acc cat cac gaa tat atc         48
Phe Asn Cys Thr Leu Arg Gly Gly Asn Val Thr His His Glu Tyr Ile           
1               5                   10                  15                

caa gtc ggc aaa gga cgc gac gtc ggc ctg aat caa gtg tcg atg ttc         96
Gln Val Gly Lys Gly Arg Asp Val Gly Leu Asn Gln Val Ser Met Phe           
            20                  25                  30                    

gag gcg aaa gtc gcc tcc ggt aac ggc gag cag acg ctg agc cgc gac        144
Glu Ala Lys Val Ala Ser Gly Asn Gly Glu Gln Thr Leu Ser Arg Asp           
        35                  40                  45                        

gtg tac cgg ctc ggg cat cgg ctg gat                                    171
Val Tyr Arg Leu Gly His Arg Leu Asp                                       
    50                  55                                                


<210>  12
<211>  57
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  12

Phe Asn Cys Thr Leu Arg Gly Gly Asn Val Thr His His Glu Tyr Ile 
1               5                   10                  15      


Gln Val Gly Lys Gly Arg Asp Val Gly Leu Asn Gln Val Ser Met Phe 
            20                  25                  30          


Glu Ala Lys Val Ala Ser Gly Asn Gly Glu Gln Thr Leu Ser Arg Asp 
        35                  40                  45              


Val Tyr Arg Leu Gly His Arg Leu Asp 
    50                  55          


<210>  13
<211>  450
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  CDS
<222>  (1)..(450)
<223>  Zea mays (corn): portion of 1,3-D-glucan synthase (codon 
       optimized)

<400>  13
cag ctg aag cgc ctg cat ctc ctc ctc acc gtc aaa gac agc gcc acc         48
Gln Leu Lys Arg Leu His Leu Leu Leu Thr Val Lys Asp Ser Ala Thr           
1               5                   10                  15                

aac atc ccg aag aat ctt gag gcc cgg cgg cgc ctg cag ttc ttc acg         96
Asn Ile Pro Lys Asn Leu Glu Ala Arg Arg Arg Leu Gln Phe Phe Thr           
            20                  25                  30                    

aac agc ctg ttc atg gat atc ccg caa gcg aag ccc gtg tcc gag atg        144
Asn Ser Leu Phe Met Asp Ile Pro Gln Ala Lys Pro Val Ser Glu Met           
        35                  40                  45                        

atc ccg ttt tcg gtg ttc acc ccg tac tac tcg gag act gtt ctc tat        192
Ile Pro Phe Ser Val Phe Thr Pro Tyr Tyr Ser Glu Thr Val Leu Tyr           
    50                  55                  60                            

tcc atg tcc gag ctg tgc gtc gag aat gag gac ggc atc agt att ctg        240
Ser Met Ser Glu Leu Cys Val Glu Asn Glu Asp Gly Ile Ser Ile Leu           
65                  70                  75                  80            

ttc tac ctc caa aag atc tat ccc gac gag tgg gca aac ttc ctg gag        288
Phe Tyr Leu Gln Lys Ile Tyr Pro Asp Glu Trp Ala Asn Phe Leu Glu           
                85                  90                  95                

cgc atc ggg tgc ggc gag tcg agc gaa gat gac ttc aaa gaa tcg ccg        336
Arg Ile Gly Cys Gly Glu Ser Ser Glu Asp Asp Phe Lys Glu Ser Pro           
            100                 105                 110                   

tcc gac acg atg gaa ttg cgg ttc tgg gtg agc tac cgc ggt cag acc        384
Ser Asp Thr Met Glu Leu Arg Phe Trp Val Ser Tyr Arg Gly Gln Thr           
        115                 120                 125                       

ctc ggc cgc acc gtc cgg ggc atg atg tat tac cgc agg gcg ctg atg        432
Leu Gly Arg Thr Val Arg Gly Met Met Tyr Tyr Arg Arg Ala Leu Met           
    130                 135                 140                           

ctc cag tcg tat ctg gag                                                450
Leu Gln Ser Tyr Leu Glu                                                   
145                 150                                                   


<210>  14
<211>  150
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  14

Gln Leu Lys Arg Leu His Leu Leu Leu Thr Val Lys Asp Ser Ala Thr 
1               5                   10                  15      


Asn Ile Pro Lys Asn Leu Glu Ala Arg Arg Arg Leu Gln Phe Phe Thr 
            20                  25                  30          


Asn Ser Leu Phe Met Asp Ile Pro Gln Ala Lys Pro Val Ser Glu Met 
        35                  40                  45              


Ile Pro Phe Ser Val Phe Thr Pro Tyr Tyr Ser Glu Thr Val Leu Tyr 
    50                  55                  60                  


Ser Met Ser Glu Leu Cys Val Glu Asn Glu Asp Gly Ile Ser Ile Leu 
65                  70                  75                  80  


Phe Tyr Leu Gln Lys Ile Tyr Pro Asp Glu Trp Ala Asn Phe Leu Glu 
                85                  90                  95      


Arg Ile Gly Cys Gly Glu Ser Ser Glu Asp Asp Phe Lys Glu Ser Pro 
            100                 105                 110         


Ser Asp Thr Met Glu Leu Arg Phe Trp Val Ser Tyr Arg Gly Gln Thr 
        115                 120                 125             


Leu Gly Arg Thr Val Arg Gly Met Met Tyr Tyr Arg Arg Ala Leu Met 
    130                 135                 140                 


Leu Gln Ser Tyr Leu Glu 
145                 150 


<210>  15
<211>  405
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  CDS
<222>  (1)..(405)
<223>  Oryza sativa (rice) portion of  1,3-beta-D-glucan synthase (codon
       optimized)

<400>  15
gag aac tat cgc ctc tac tcg cgc tcc cat ttc gtc aaa gca ctc gaa         48
Glu Asn Tyr Arg Leu Tyr Ser Arg Ser His Phe Val Lys Ala Leu Glu           
1               5                   10                  15                

gtt gcc ctg ctg ctc atc atc tat att gcg tac ggc tat acc cgg ggg         96
Val Ala Leu Leu Leu Ile Ile Tyr Ile Ala Tyr Gly Tyr Thr Arg Gly           
            20                  25                  30                    

ggc tcc tcc agc ttc atc ctg ttg acc att agt tcg tgg ttc ctc gtc        144
Gly Ser Ser Ser Phe Ile Leu Leu Thr Ile Ser Ser Trp Phe Leu Val           
        35                  40                  45                        

gtg tcg tgg ctg ttc gct ccc tac ata ttc aac ccg agc ggc ttt gag        192
Val Ser Trp Leu Phe Ala Pro Tyr Ile Phe Asn Pro Ser Gly Phe Glu           
    50                  55                  60                            

tgg cag aaa acc gtc gag gac ttc gac gat tgg acg aat tgg ctc ctg        240
Trp Gln Lys Thr Val Glu Asp Phe Asp Asp Trp Thr Asn Trp Leu Leu           
65                  70                  75                  80            

tac aag ggc gga gtg ggc gtg aag ggt gag aat agc tgg gag tcc tgg        288
Tyr Lys Gly Gly Val Gly Val Lys Gly Glu Asn Ser Trp Glu Ser Trp           
                85                  90                  95                

tgg gac gag gaa cag gcg cat atc caa acg ctg agg ggt cgg atc ctt        336
Trp Asp Glu Glu Gln Ala His Ile Gln Thr Leu Arg Gly Arg Ile Leu           
            100                 105                 110                   

gag act atc ctg tcg ctg cgc ttc ctc atc ttc cag tac ggc atc gtc        384
Glu Thr Ile Leu Ser Leu Arg Phe Leu Ile Phe Gln Tyr Gly Ile Val           
        115                 120                 125                       

tat aag ctc aag atc gcc cac                                            405
Tyr Lys Leu Lys Ile Ala His                                               
    130                 135                                               


<210>  16
<211>  135
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  16

Glu Asn Tyr Arg Leu Tyr Ser Arg Ser His Phe Val Lys Ala Leu Glu 
1               5                   10                  15      


Val Ala Leu Leu Leu Ile Ile Tyr Ile Ala Tyr Gly Tyr Thr Arg Gly 
            20                  25                  30          


Gly Ser Ser Ser Phe Ile Leu Leu Thr Ile Ser Ser Trp Phe Leu Val 
        35                  40                  45              


Val Ser Trp Leu Phe Ala Pro Tyr Ile Phe Asn Pro Ser Gly Phe Glu 
    50                  55                  60                  


Trp Gln Lys Thr Val Glu Asp Phe Asp Asp Trp Thr Asn Trp Leu Leu 
65                  70                  75                  80  


Tyr Lys Gly Gly Val Gly Val Lys Gly Glu Asn Ser Trp Glu Ser Trp 
                85                  90                  95      


Trp Asp Glu Glu Gln Ala His Ile Gln Thr Leu Arg Gly Arg Ile Leu 
            100                 105                 110         


Glu Thr Ile Leu Ser Leu Arg Phe Leu Ile Phe Gln Tyr Gly Ile Val 
        115                 120                 125             


Tyr Lys Leu Lys Ile Ala His 
    130                 135 


<210>  17
<211>  306
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  CDS
<222>  (1)..(306)
<223>  Oryza sativa (rice)  portion of 1,3-beta-D-glucan synthase (codon
       optimized)

<400>  17
tgg gtc gtt gct ttc gcc atc ctg tac aaa gaa gcc tgg aac aac cgc         48
Trp Val Val Ala Phe Ala Ile Leu Tyr Lys Glu Ala Trp Asn Asn Arg           
1               5                   10                  15                

aat tcg aat agc caa atc atg cgc ttt ttg tat gca gcc gcg gtg ttc         96
Asn Ser Asn Ser Gln Ile Met Arg Phe Leu Tyr Ala Ala Ala Val Phe           
            20                  25                  30                    

atg atc ccc gag gtc ctg gcg atc gtg ctg ttc atc gtc ccg tgg gtc        144
Met Ile Pro Glu Val Leu Ala Ile Val Leu Phe Ile Val Pro Trp Val           
        35                  40                  45                        

cgg aac gcc ctg gag aaa acc aat tgg aag att tgc tat gcg ctc acc        192
Arg Asn Ala Leu Glu Lys Thr Asn Trp Lys Ile Cys Tyr Ala Leu Thr           
    50                  55                  60                            

tgg tgg ttc cag agc cgc tcg ttc gtg ggt cgg ggc ctc cgc gag ggc        240
Trp Trp Phe Gln Ser Arg Ser Phe Val Gly Arg Gly Leu Arg Glu Gly           
65                  70                  75                  80            

acg ttc gac aac gtg aag tac tcc gtg ttc tgg gtc ctt ctc ctc gcg        288
Thr Phe Asp Asn Val Lys Tyr Ser Val Phe Trp Val Leu Leu Leu Ala           
                85                  90                  95                

gtc aag ttc gcg ttc tcc                                                306
Val Lys Phe Ala Phe Ser                                                   
            100                                                           


<210>  18
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  18

Trp Val Val Ala Phe Ala Ile Leu Tyr Lys Glu Ala Trp Asn Asn Arg 
1               5                   10                  15      


Asn Ser Asn Ser Gln Ile Met Arg Phe Leu Tyr Ala Ala Ala Val Phe 
            20                  25                  30          


Met Ile Pro Glu Val Leu Ala Ile Val Leu Phe Ile Val Pro Trp Val 
        35                  40                  45              


Arg Asn Ala Leu Glu Lys Thr Asn Trp Lys Ile Cys Tyr Ala Leu Thr 
    50                  55                  60                  


Trp Trp Phe Gln Ser Arg Ser Phe Val Gly Arg Gly Leu Arg Glu Gly 
65                  70                  75                  80  


Thr Phe Asp Asn Val Lys Tyr Ser Val Phe Trp Val Leu Leu Leu Ala 
                85                  90                  95      


Val Lys Phe Ala Phe Ser 
            100         


<210>  19
<211>  435
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  CDS
<222>  (1)..(435)
<223>  Gycine max (soy) portion of 1,3-beta-D-glucan synthase (codon 
       optimized)

<400>  19
ttg agg tcc tcg gaa atg cgg aaa att ata gcc acg ctg cgc gct ctt         48
Leu Arg Ser Ser Glu Met Arg Lys Ile Ile Ala Thr Leu Arg Ala Leu           
1               5                   10                  15                

gtt gaa gtc ttg gaa tcc ctg tcg aag gac gcg gat ccg ggt ggc gtc         96
Val Glu Val Leu Glu Ser Leu Ser Lys Asp Ala Asp Pro Gly Gly Val           
            20                  25                  30                    

ggt ggc ctg atc atg gaa gaa ctc cgg aag atc aag aaa tcg agt gtg        144
Gly Gly Leu Ile Met Glu Glu Leu Arg Lys Ile Lys Lys Ser Ser Val           
        35                  40                  45                        

acc ctg tcg ggc gag ctc acc ccc tat aac atc att ccg ctt gag gcg        192
Thr Leu Ser Gly Glu Leu Thr Pro Tyr Asn Ile Ile Pro Leu Glu Ala           
    50                  55                  60                            

ccg tcc ctc acc aat ccc atc cgg atc ttc ccc gag gtg aag gcc gcg        240
Pro Ser Leu Thr Asn Pro Ile Arg Ile Phe Pro Glu Val Lys Ala Ala           
65                  70                  75                  80            

atc agc gcg atc cgc tac acg gac cag ttc cca cgc ctc cct gcc ggc        288
Ile Ser Ala Ile Arg Tyr Thr Asp Gln Phe Pro Arg Leu Pro Ala Gly           
                85                  90                  95                

ttc aag atc agc ggg cag cgc gac gcg gat atg ttc gac ctc ctg gag        336
Phe Lys Ile Ser Gly Gln Arg Asp Ala Asp Met Phe Asp Leu Leu Glu           
            100                 105                 110                   

ttc gtc ttt gga ttc cag aaa gac aac gtg cgc aac cag cgg gag aat        384
Phe Val Phe Gly Phe Gln Lys Asp Asn Val Arg Asn Gln Arg Glu Asn           
        115                 120                 125                       

gtc gtg ctg atg atc gcc aac aag caa agc cgc ctc ggc atc ccg gca        432
Val Val Leu Met Ile Ala Asn Lys Gln Ser Arg Leu Gly Ile Pro Ala           
    130                 135                 140                           

gag                                                                    435
Glu                                                                       
145                                                                       


<210>  20
<211>  145
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  20

Leu Arg Ser Ser Glu Met Arg Lys Ile Ile Ala Thr Leu Arg Ala Leu 
1               5                   10                  15      


Val Glu Val Leu Glu Ser Leu Ser Lys Asp Ala Asp Pro Gly Gly Val 
            20                  25                  30          


Gly Gly Leu Ile Met Glu Glu Leu Arg Lys Ile Lys Lys Ser Ser Val 
        35                  40                  45              


Thr Leu Ser Gly Glu Leu Thr Pro Tyr Asn Ile Ile Pro Leu Glu Ala 
    50                  55                  60                  


Pro Ser Leu Thr Asn Pro Ile Arg Ile Phe Pro Glu Val Lys Ala Ala 
65                  70                  75                  80  


Ile Ser Ala Ile Arg Tyr Thr Asp Gln Phe Pro Arg Leu Pro Ala Gly 
                85                  90                  95      


Phe Lys Ile Ser Gly Gln Arg Asp Ala Asp Met Phe Asp Leu Leu Glu 
            100                 105                 110         


Phe Val Phe Gly Phe Gln Lys Asp Asn Val Arg Asn Gln Arg Glu Asn 
        115                 120                 125             


Val Val Leu Met Ile Ala Asn Lys Gln Ser Arg Leu Gly Ile Pro Ala 
    130                 135                 140                 


Glu 
145 


<210>  21
<211>  489
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  CDS
<222>  (1)..(489)
<223>  Veronia mespilifolia 1,3-beta-D-glucan synthase  (codon 
       optimized)

<400>  21
tat ggc cat cca gat gtc ttt gac cgc gtt ttt cat att acc agg gga         48
Tyr Gly His Pro Asp Val Phe Asp Arg Val Phe His Ile Thr Arg Gly           
1               5                   10                  15                

gga atc agt aaa gct agc cgc gtg atc aat atc tcc gaa gat atc tat         96
Gly Ile Ser Lys Ala Ser Arg Val Ile Asn Ile Ser Glu Asp Ile Tyr           
            20                  25                  30                    

gcc ggc ttc aat tcc acc ctg cgg caa ggc aat atc acc cac cac gag        144
Ala Gly Phe Asn Ser Thr Leu Arg Gln Gly Asn Ile Thr His His Glu           
        35                  40                  45                        

tat atc cag gtc ggt aag ggc cgc gac gtc ggc ctg aac cag att gcc        192
Tyr Ile Gln Val Gly Lys Gly Arg Asp Val Gly Leu Asn Gln Ile Ala           
    50                  55                  60                            

ctc ttc gag ggc aag gtc gcg ggc ggg aac ggc gag caa gtc ctc tcg        240
Leu Phe Glu Gly Lys Val Ala Gly Gly Asn Gly Glu Gln Val Leu Ser           
65                  70                  75                  80            

cgc gac atc tac cgc ctc ggc cag ctg ttc gac ttc ttc cgg atg ctg        288
Arg Asp Ile Tyr Arg Leu Gly Gln Leu Phe Asp Phe Phe Arg Met Leu           
                85                  90                  95                

tcg ttc tac ttc acg acc gtg ggg tac tat ttc tgc acc atg ctg acc        336
Ser Phe Tyr Phe Thr Thr Val Gly Tyr Tyr Phe Cys Thr Met Leu Thr           
            100                 105                 110                   

gtg acg act gtg tac ata ttc ctc tat ggt aag acc tac ttg gcc ctg        384
Val Thr Thr Val Tyr Ile Phe Leu Tyr Gly Lys Thr Tyr Leu Ala Leu           
        115                 120                 125                       

tcg ggt gtc ggc gag gac atc cag aac cgg agc gaa gtc ctc gac aac        432
Ser Gly Val Gly Glu Asp Ile Gln Asn Arg Ser Glu Val Leu Asp Asn           
    130                 135                 140                           

aaa gcg ctt acc gca gcg ctg aac acg cag ttc ctc ttc cag atc ggc        480
Lys Ala Leu Thr Ala Ala Leu Asn Thr Gln Phe Leu Phe Gln Ile Gly           
145                 150                 155                 160           

gtg ttc acg                                                            489
Val Phe Thr                                                               
                                                                          


<210>  22
<211>  163
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  22

Tyr Gly His Pro Asp Val Phe Asp Arg Val Phe His Ile Thr Arg Gly 
1               5                   10                  15      


Gly Ile Ser Lys Ala Ser Arg Val Ile Asn Ile Ser Glu Asp Ile Tyr 
            20                  25                  30          


Ala Gly Phe Asn Ser Thr Leu Arg Gln Gly Asn Ile Thr His His Glu 
        35                  40                  45              


Tyr Ile Gln Val Gly Lys Gly Arg Asp Val Gly Leu Asn Gln Ile Ala 
    50                  55                  60                  


Leu Phe Glu Gly Lys Val Ala Gly Gly Asn Gly Glu Gln Val Leu Ser 
65                  70                  75                  80  


Arg Asp Ile Tyr Arg Leu Gly Gln Leu Phe Asp Phe Phe Arg Met Leu 
                85                  90                  95      


Ser Phe Tyr Phe Thr Thr Val Gly Tyr Tyr Phe Cys Thr Met Leu Thr 
            100                 105                 110         


Val Thr Thr Val Tyr Ile Phe Leu Tyr Gly Lys Thr Tyr Leu Ala Leu 
        115                 120                 125             


Ser Gly Val Gly Glu Asp Ile Gln Asn Arg Ser Glu Val Leu Asp Asn 
    130                 135                 140                 


Lys Ala Leu Thr Ala Ala Leu Asn Thr Gln Phe Leu Phe Gln Ile Gly 
145                 150                 155                 160 


Val Phe Thr 
            


<210>  23
<211>  1467
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  CDS
<222>  (1)..(1467)
<223>  Triticum aestivum (wheat) 1,3-beta-D-glucan synthase (codon 
       optimized)

<400>  23
cgc gtg ggg aag ggt agg gat gtc ggc ttg aat caa atc agt atg ttc         48
Arg Val Gly Lys Gly Arg Asp Val Gly Leu Asn Gln Ile Ser Met Phe           
1               5                   10                  15                

gaa gca aaa gtg gct ggg gga aat ggt gag cag act ctg tcc cgc gac         96
Glu Ala Lys Val Ala Gly Gly Asn Gly Glu Gln Thr Leu Ser Arg Asp           
            20                  25                  30                    

gtc tac cgc ctt ggc cat ggc ctg gac ttc ttc cgg atg ctg agc ttc        144
Val Tyr Arg Leu Gly His Gly Leu Asp Phe Phe Arg Met Leu Ser Phe           
        35                  40                  45                        

ttc tac acg acc atc ggc ttt tac ctc aat acc atg atg gtc gtc ctc        192
Phe Tyr Thr Thr Ile Gly Phe Tyr Leu Asn Thr Met Met Val Val Leu           
    50                  55                  60                            

acg gtg tac gcc ttc gtg tgg ggt cgg ttc tac ctc gcg ctg tcg ggc        240
Thr Val Tyr Ala Phe Val Trp Gly Arg Phe Tyr Leu Ala Leu Ser Gly           
65                  70                  75                  80            

ctt gag gcc gac tat atc acc aat aac acc tcc tcg acc gat aat gcc        288
Leu Glu Ala Asp Tyr Ile Thr Asn Asn Thr Ser Ser Thr Asp Asn Ala           
                85                  90                  95                

gcg ctg tgg gca gtg ctc aac caa cag ttc ttc atc caa ttc ggc ctc        336
Ala Leu Trp Ala Val Leu Asn Gln Gln Phe Phe Ile Gln Phe Gly Leu           
            100                 105                 110                   

ttc acg gcc ctc ccc atg atc atc gag aac tcc ctt gag cat ggc ttc        384
Phe Thr Ala Leu Pro Met Ile Ile Glu Asn Ser Leu Glu His Gly Phe           
        115                 120                 125                       

ctc ata gcc gtc tgg gac ttc atc gtc atg cag ctg cag tgc gcg tcg        432
Leu Ile Ala Val Trp Asp Phe Ile Val Met Gln Leu Gln Cys Ala Ser           
    130                 135                 140                           

gtg ttc tat acc ttc tgc atg ggc acc aag act cac tat tat ggc cgc        480
Val Phe Tyr Thr Phe Cys Met Gly Thr Lys Thr His Tyr Tyr Gly Arg           
145                 150                 155                 160           

acg ctg ctg cat ggt ggg gcc aag tac cgc cca acc ggt cgg ggc ttc        528
Thr Leu Leu His Gly Gly Ala Lys Tyr Arg Pro Thr Gly Arg Gly Phe           
                165                 170                 175               

gtg gtc gag cac aag aaa ttc gcc gag aac tac cgg ctg tat gcg cgc        576
Val Val Glu His Lys Lys Phe Ala Glu Asn Tyr Arg Leu Tyr Ala Arg           
            180                 185                 190                   

agc cat ttc acc aag gct atc gag ctg ggc gtg atc ttg tgt ttg tat        624
Ser His Phe Thr Lys Ala Ile Glu Leu Gly Val Ile Leu Cys Leu Tyr           
        195                 200                 205                       

tcc tcg tac agc aac atc gct ggc gac acc ctg gtg tat att ctg ctg        672
Ser Ser Tyr Ser Asn Ile Ala Gly Asp Thr Leu Val Tyr Ile Leu Leu           
    210                 215                 220                           

acc ctc tcg tcg tgg ttt ctc gtc tgc tcc tgg atc ctc gcg ccg ttc        720
Thr Leu Ser Ser Trp Phe Leu Val Cys Ser Trp Ile Leu Ala Pro Phe           
225                 230                 235                 240           

atc ttc aac ccg agc gga ctc gat tgg cag aag aat tcc aac gac ttc        768
Ile Phe Asn Pro Ser Gly Leu Asp Trp Gln Lys Asn Ser Asn Asp Phe           
                245                 250                 255               

gag gat ttc ttc tcg tgg atc tgg ttt cag ggc ggc ggc atc agt gtc        816
Glu Asp Phe Phe Ser Trp Ile Trp Phe Gln Gly Gly Gly Ile Ser Val           
            260                 265                 270                   

aag tcc gac cag agc tgg gag aag tgg tgg gag gaa gaa acc gac cat        864
Lys Ser Asp Gln Ser Trp Glu Lys Trp Trp Glu Glu Glu Thr Asp His           
        275                 280                 285                       

ctg gcg cgg acg acg acc ggc ctg tgg ggc agc atc atc gag ata att        912
Leu Ala Arg Thr Thr Thr Gly Leu Trp Gly Ser Ile Ile Glu Ile Ile           
    290                 295                 300                           

ctg gac ctg gcg cgc acc tac ttt ttc ttc cag tat gcg atc gtt tat        960
Leu Asp Leu Ala Arg Thr Tyr Phe Phe Phe Gln Tyr Ala Ile Val Tyr           
305                 310                 315                 320           

cgc ctc cac atg gcc ggt ggc agc cgc tcc atc ctg gtc tat gtg ctc       1008
Arg Leu His Met Ala Gly Gly Ser Arg Ser Ile Leu Val Tyr Val Leu           
                325                 330                 335               

tcg tgg gcg tgc atc ccg ctc ccg ttc ctg gcg ctg gtc acc gtg acg       1056
Ser Trp Ala Cys Ile Pro Leu Pro Phe Leu Ala Leu Val Thr Val Thr           
            340                 345                 350                   

tac ttc cgc gac aag tac tcg gcc aag aaa cat atc cgg tac cgc ctt       1104
Tyr Phe Arg Asp Lys Tyr Ser Ala Lys Lys His Ile Arg Tyr Arg Leu           
        355                 360                 365                       

gtt caa tcg gtg att gtc tgc gca agc ctg gcg gcg att atc gtg ctc       1152
Val Gln Ser Val Ile Val Cys Ala Ser Leu Ala Ala Ile Ile Val Leu           
    370                 375                 380                           

ctc acc ctc acc aag ttc cag ttc atc gac acc ttc acc agc ctc ctg       1200
Leu Thr Leu Thr Lys Phe Gln Phe Ile Asp Thr Phe Thr Ser Leu Leu           
385                 390                 395                 400           

gcc ttt ctg ccc acc ggc tgg ggc atc atc tcc atc gcc ctg gtg ttc       1248
Ala Phe Leu Pro Thr Gly Trp Gly Ile Ile Ser Ile Ala Leu Val Phe           
                405                 410                 415               

cgc caa tat ctg aag aaa agc gac acg gtg tgg aaa acc gtc gtc gtg       1296
Arg Gln Tyr Leu Lys Lys Ser Asp Thr Val Trp Lys Thr Val Val Val           
            420                 425                 430                   

gtc gcg cgg ttc tac gac atc acc ctc ggc ctg att gtt atg gcg ccg       1344
Val Ala Arg Phe Tyr Asp Ile Thr Leu Gly Leu Ile Val Met Ala Pro           
        435                 440                 445                       

atc gtc gtc ctg tcg tgg ctc cct ggc ctc cgc gag ctg cag acg cgg       1392
Ile Val Val Leu Ser Trp Leu Pro Gly Leu Arg Glu Leu Gln Thr Arg           
    450                 455                 460                           

atc ttg ttc aac gaa gcc ttc tcc aag ggc ctc cac atc tcg cag atg       1440
Ile Leu Phe Asn Glu Ala Phe Ser Lys Gly Leu His Ile Ser Gln Met           
465                 470                 475                 480           

atc acg cgc agg aaa acg cat cgc gcc                                   1467
Ile Thr Arg Arg Lys Thr His Arg Ala                                       
                485                                                       


<210>  24
<211>  489
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  24

Arg Val Gly Lys Gly Arg Asp Val Gly Leu Asn Gln Ile Ser Met Phe 
1               5                   10                  15      


Glu Ala Lys Val Ala Gly Gly Asn Gly Glu Gln Thr Leu Ser Arg Asp 
            20                  25                  30          


Val Tyr Arg Leu Gly His Gly Leu Asp Phe Phe Arg Met Leu Ser Phe 
        35                  40                  45              


Phe Tyr Thr Thr Ile Gly Phe Tyr Leu Asn Thr Met Met Val Val Leu 
    50                  55                  60                  


Thr Val Tyr Ala Phe Val Trp Gly Arg Phe Tyr Leu Ala Leu Ser Gly 
65                  70                  75                  80  


Leu Glu Ala Asp Tyr Ile Thr Asn Asn Thr Ser Ser Thr Asp Asn Ala 
                85                  90                  95      


Ala Leu Trp Ala Val Leu Asn Gln Gln Phe Phe Ile Gln Phe Gly Leu 
            100                 105                 110         


Phe Thr Ala Leu Pro Met Ile Ile Glu Asn Ser Leu Glu His Gly Phe 
        115                 120                 125             


Leu Ile Ala Val Trp Asp Phe Ile Val Met Gln Leu Gln Cys Ala Ser 
    130                 135                 140                 


Val Phe Tyr Thr Phe Cys Met Gly Thr Lys Thr His Tyr Tyr Gly Arg 
145                 150                 155                 160 


Thr Leu Leu His Gly Gly Ala Lys Tyr Arg Pro Thr Gly Arg Gly Phe 
                165                 170                 175     


Val Val Glu His Lys Lys Phe Ala Glu Asn Tyr Arg Leu Tyr Ala Arg 
            180                 185                 190         


Ser His Phe Thr Lys Ala Ile Glu Leu Gly Val Ile Leu Cys Leu Tyr 
        195                 200                 205             


Ser Ser Tyr Ser Asn Ile Ala Gly Asp Thr Leu Val Tyr Ile Leu Leu 
    210                 215                 220                 


Thr Leu Ser Ser Trp Phe Leu Val Cys Ser Trp Ile Leu Ala Pro Phe 
225                 230                 235                 240 


Ile Phe Asn Pro Ser Gly Leu Asp Trp Gln Lys Asn Ser Asn Asp Phe 
                245                 250                 255     


Glu Asp Phe Phe Ser Trp Ile Trp Phe Gln Gly Gly Gly Ile Ser Val 
            260                 265                 270         


Lys Ser Asp Gln Ser Trp Glu Lys Trp Trp Glu Glu Glu Thr Asp His 
        275                 280                 285             


Leu Ala Arg Thr Thr Thr Gly Leu Trp Gly Ser Ile Ile Glu Ile Ile 
    290                 295                 300                 


Leu Asp Leu Ala Arg Thr Tyr Phe Phe Phe Gln Tyr Ala Ile Val Tyr 
305                 310                 315                 320 


Arg Leu His Met Ala Gly Gly Ser Arg Ser Ile Leu Val Tyr Val Leu 
                325                 330                 335     


Ser Trp Ala Cys Ile Pro Leu Pro Phe Leu Ala Leu Val Thr Val Thr 
            340                 345                 350         


Tyr Phe Arg Asp Lys Tyr Ser Ala Lys Lys His Ile Arg Tyr Arg Leu 
        355                 360                 365             


Val Gln Ser Val Ile Val Cys Ala Ser Leu Ala Ala Ile Ile Val Leu 
    370                 375                 380                 


Leu Thr Leu Thr Lys Phe Gln Phe Ile Asp Thr Phe Thr Ser Leu Leu 
385                 390                 395                 400 


Ala Phe Leu Pro Thr Gly Trp Gly Ile Ile Ser Ile Ala Leu Val Phe 
                405                 410                 415     


Arg Gln Tyr Leu Lys Lys Ser Asp Thr Val Trp Lys Thr Val Val Val 
            420                 425                 430         


Val Ala Arg Phe Tyr Asp Ile Thr Leu Gly Leu Ile Val Met Ala Pro 
        435                 440                 445             


Ile Val Val Leu Ser Trp Leu Pro Gly Leu Arg Glu Leu Gln Thr Arg 
    450                 455                 460                 


Ile Leu Phe Asn Glu Ala Phe Ser Lys Gly Leu His Ile Ser Gln Met 
465                 470                 475                 480 


Ile Thr Arg Arg Lys Thr His Arg Ala 
                485                 


<210>  25
<211>  336
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  CDS
<222>  (1)..(336)
<223>  Horderum vulgars (barley) 1,3-beta-D-glucan synthase (codon 
       optimized)

<400>  25
att gcc gga gca gcc gct gga atc gct gga acc ctc atg tgt cac ccc         48
Ile Ala Gly Ala Ala Ala Gly Ile Ala Gly Thr Leu Met Cys His Pro           
1               5                   10                  15                

ctc gaa gtc ata aaa gat cgc ttg acc gtc gac agg gtg acg tat ccg         96
Leu Glu Val Ile Lys Asp Arg Leu Thr Val Asp Arg Val Thr Tyr Pro           
            20                  25                  30                    

tcg atc agc atc gcg ttc tcg aag atc tac cgg acc gag ggc atc cgc        144
Ser Ile Ser Ile Ala Phe Ser Lys Ile Tyr Arg Thr Glu Gly Ile Arg           
        35                  40                  45                        

ggc ctg tat agc ggc ctg tgc ccc acc ctc att ggc atg ctg ccg tac        192
Gly Leu Tyr Ser Gly Leu Cys Pro Thr Leu Ile Gly Met Leu Pro Tyr           
    50                  55                  60                            

tcg act tgc tac tat ttc atg tat gac acg atc aag acc tcc tac tgc        240
Ser Thr Cys Tyr Tyr Phe Met Tyr Asp Thr Ile Lys Thr Ser Tyr Cys           
65                  70                  75                  80            

cgg ctc cat aag aaa aag tcg ctg agt cgc cct gag ctg ctg atc atc        288
Arg Leu His Lys Lys Lys Ser Leu Ser Arg Pro Glu Leu Leu Ile Ile           
                85                  90                  95                

ggt gcg ctt acc agc ctc acc gcg tcc acg atc tcc ttc ccg ctg gag        336
Gly Ala Leu Thr Ser Leu Thr Ala Ser Thr Ile Ser Phe Pro Leu Glu           
            100                 105                 110                   


<210>  26
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  26

Ile Ala Gly Ala Ala Ala Gly Ile Ala Gly Thr Leu Met Cys His Pro 
1               5                   10                  15      


Leu Glu Val Ile Lys Asp Arg Leu Thr Val Asp Arg Val Thr Tyr Pro 
            20                  25                  30          


Ser Ile Ser Ile Ala Phe Ser Lys Ile Tyr Arg Thr Glu Gly Ile Arg 
        35                  40                  45              


Gly Leu Tyr Ser Gly Leu Cys Pro Thr Leu Ile Gly Met Leu Pro Tyr 
    50                  55                  60                  


Ser Thr Cys Tyr Tyr Phe Met Tyr Asp Thr Ile Lys Thr Ser Tyr Cys 
65                  70                  75                  80  


Arg Leu His Lys Lys Lys Ser Leu Ser Arg Pro Glu Leu Leu Ile Ile 
                85                  90                  95      


Gly Ala Leu Thr Ser Leu Thr Ala Ser Thr Ile Ser Phe Pro Leu Glu 
            100                 105                 110         


<210>  27
<211>  1293
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  CDS
<222>  (1)..(1293)
<223>  E.coli Glucose-1-phosphate adenyltransfersase (Acc. No. YP 
       49003.1) (codon optimized)

<400>  27
atg gtt tcc ctg gag aaa aat gac cac ctg atg ctc gca cgc caa ctc         48
Met Val Ser Leu Glu Lys Asn Asp His Leu Met Leu Ala Arg Gln Leu           
1               5                   10                  15                

ccg ctt aag tcc gtc gcc ctg atc ctc gcc ggc gga cgc ggc acg cgg         96
Pro Leu Lys Ser Val Ala Leu Ile Leu Ala Gly Gly Arg Gly Thr Arg           
            20                  25                  30                    

ctc aaa gac ctc acc aac aag cgc gcg aaa ccg gct gtc cat ttc ggt        144
Leu Lys Asp Leu Thr Asn Lys Arg Ala Lys Pro Ala Val His Phe Gly           
        35                  40                  45                        

ggc aag ttc agg atc ata gac ttc gcg ctg tcg aac tgc atc aat tcc        192
Gly Lys Phe Arg Ile Ile Asp Phe Ala Leu Ser Asn Cys Ile Asn Ser           
    50                  55                  60                            

ggc att agg cgc atg gga gtc att acc cag tac caa tcg cat acg ctc        240
Gly Ile Arg Arg Met Gly Val Ile Thr Gln Tyr Gln Ser His Thr Leu           
65                  70                  75                  80            

gtc cag cat atc cag cgg ggc tgg tcg ttc ttc aac gaa gag atg aac        288
Val Gln His Ile Gln Arg Gly Trp Ser Phe Phe Asn Glu Glu Met Asn           
                85                  90                  95                

gag ttc gtc gac ctc ctc ccg gcg cag cag cgg atg aaa ggc gag aac        336
Glu Phe Val Asp Leu Leu Pro Ala Gln Gln Arg Met Lys Gly Glu Asn           
            100                 105                 110                   

tgg tac cgc ggc acg gct gat gcc gtt acc cag aac ctg gac att att        384
Trp Tyr Arg Gly Thr Ala Asp Ala Val Thr Gln Asn Leu Asp Ile Ile           
        115                 120                 125                       

cgc cgc tat aaa gcc gag tat gtt gtg atc ctg gcc ggt gac cac atc        432
Arg Arg Tyr Lys Ala Glu Tyr Val Val Ile Leu Ala Gly Asp His Ile           
    130                 135                 140                           

tac aaa caa gac tat agt cgg atg ctc atc gac cat gtg gaa aag ggc        480
Tyr Lys Gln Asp Tyr Ser Arg Met Leu Ile Asp His Val Glu Lys Gly           
145                 150                 155                 160           

gct cgc tgc acc gtg gcg tgc atg cca gtg ccg atc gaa gag gcc tcc        528
Ala Arg Cys Thr Val Ala Cys Met Pro Val Pro Ile Glu Glu Ala Ser           
                165                 170                 175               

gcg ttc ggc gtg atg gcc gtg gat gag aac gac aag atc atc gag ttc        576
Ala Phe Gly Val Met Ala Val Asp Glu Asn Asp Lys Ile Ile Glu Phe           
            180                 185                 190                   

gtg gag aag ccc gcg aac ccg ccg tcg atg ccc aac gac ccg agc aag        624
Val Glu Lys Pro Ala Asn Pro Pro Ser Met Pro Asn Asp Pro Ser Lys           
        195                 200                 205                       

agc ctg gcg tcc atg ggc atc tac gtc ttt gac gcg gat tat ctg tac        672
Ser Leu Ala Ser Met Gly Ile Tyr Val Phe Asp Ala Asp Tyr Leu Tyr           
    210                 215                 220                           

gag ctt ttg gaa gag gat gat cgg gac gag aat agc tcg cac gac ttc        720
Glu Leu Leu Glu Glu Asp Asp Arg Asp Glu Asn Ser Ser His Asp Phe           
225                 230                 235                 240           

ggc aaa gac ctg atc ccg aag atc acc gaa gcc ggg ctg gcg tat gcc        768
Gly Lys Asp Leu Ile Pro Lys Ile Thr Glu Ala Gly Leu Ala Tyr Ala           
                245                 250                 255               

cat cct ttt ccg ctc agc tgc gtg cag tcg gac ccc gat gcg gag ccg        816
His Pro Phe Pro Leu Ser Cys Val Gln Ser Asp Pro Asp Ala Glu Pro           
            260                 265                 270                   

tat tgg cgc gac gtg ggt acc ctg gaa gcg tac tgg aag gcc aat ctc        864
Tyr Trp Arg Asp Val Gly Thr Leu Glu Ala Tyr Trp Lys Ala Asn Leu           
        275                 280                 285                       

gac ctc gcc agc gtg gtg ccg gaa ctg gac atg tac gac cgc aat tgg        912
Asp Leu Ala Ser Val Val Pro Glu Leu Asp Met Tyr Asp Arg Asn Trp           
    290                 295                 300                           

ccg atc cgc act tac aac gag agc ctg ccc ccg gcg aag ttc gtc cag        960
Pro Ile Arg Thr Tyr Asn Glu Ser Leu Pro Pro Ala Lys Phe Val Gln           
305                 310                 315                 320           

gac cgg agt ggc agc cac ggc atg acg ctc aat tcc ctt gtg tcg ggg       1008
Asp Arg Ser Gly Ser His Gly Met Thr Leu Asn Ser Leu Val Ser Gly           
                325                 330                 335               

ggc tgc gtc atc tcg ggt tcg gtc gtc gtc cag tcc gtc ctc ttc agc       1056
Gly Cys Val Ile Ser Gly Ser Val Val Val Gln Ser Val Leu Phe Ser           
            340                 345                 350                   

cgg gtc agg gtc aat tcc ttc tgc aac atc gat agc gca gtg ctg ttg       1104
Arg Val Arg Val Asn Ser Phe Cys Asn Ile Asp Ser Ala Val Leu Leu           
        355                 360                 365                       

ccc gag gtc tgg gtg ggc cgc tcg tgt cgg ctg cgc cgc tgc gtg atc       1152
Pro Glu Val Trp Val Gly Arg Ser Cys Arg Leu Arg Arg Cys Val Ile           
    370                 375                 380                           

gac cgc gcc tgc gtc atc ccc gag ggc atg gtc ata ggc gag aat gcc       1200
Asp Arg Ala Cys Val Ile Pro Glu Gly Met Val Ile Gly Glu Asn Ala           
385                 390                 395                 400           

gaa gag gac gcg cgg cgc ttc tat cgg tcc gag gag ggc atc gtg ctg       1248
Glu Glu Asp Ala Arg Arg Phe Tyr Arg Ser Glu Glu Gly Ile Val Leu           
                405                 410                 415               

gtc acc cgc gag atg ctg cgc aag ctc ggg cat aag caa gag cgc           1293
Val Thr Arg Glu Met Leu Arg Lys Leu Gly His Lys Gln Glu Arg               
            420                 425                 430                   


<210>  28
<211>  431
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  28

Met Val Ser Leu Glu Lys Asn Asp His Leu Met Leu Ala Arg Gln Leu 
1               5                   10                  15      


Pro Leu Lys Ser Val Ala Leu Ile Leu Ala Gly Gly Arg Gly Thr Arg 
            20                  25                  30          


Leu Lys Asp Leu Thr Asn Lys Arg Ala Lys Pro Ala Val His Phe Gly 
        35                  40                  45              


Gly Lys Phe Arg Ile Ile Asp Phe Ala Leu Ser Asn Cys Ile Asn Ser 
    50                  55                  60                  


Gly Ile Arg Arg Met Gly Val Ile Thr Gln Tyr Gln Ser His Thr Leu 
65                  70                  75                  80  


Val Gln His Ile Gln Arg Gly Trp Ser Phe Phe Asn Glu Glu Met Asn 
                85                  90                  95      


Glu Phe Val Asp Leu Leu Pro Ala Gln Gln Arg Met Lys Gly Glu Asn 
            100                 105                 110         


Trp Tyr Arg Gly Thr Ala Asp Ala Val Thr Gln Asn Leu Asp Ile Ile 
        115                 120                 125             


Arg Arg Tyr Lys Ala Glu Tyr Val Val Ile Leu Ala Gly Asp His Ile 
    130                 135                 140                 


Tyr Lys Gln Asp Tyr Ser Arg Met Leu Ile Asp His Val Glu Lys Gly 
145                 150                 155                 160 


Ala Arg Cys Thr Val Ala Cys Met Pro Val Pro Ile Glu Glu Ala Ser 
                165                 170                 175     


Ala Phe Gly Val Met Ala Val Asp Glu Asn Asp Lys Ile Ile Glu Phe 
            180                 185                 190         


Val Glu Lys Pro Ala Asn Pro Pro Ser Met Pro Asn Asp Pro Ser Lys 
        195                 200                 205             


Ser Leu Ala Ser Met Gly Ile Tyr Val Phe Asp Ala Asp Tyr Leu Tyr 
    210                 215                 220                 


Glu Leu Leu Glu Glu Asp Asp Arg Asp Glu Asn Ser Ser His Asp Phe 
225                 230                 235                 240 


Gly Lys Asp Leu Ile Pro Lys Ile Thr Glu Ala Gly Leu Ala Tyr Ala 
                245                 250                 255     


His Pro Phe Pro Leu Ser Cys Val Gln Ser Asp Pro Asp Ala Glu Pro 
            260                 265                 270         


Tyr Trp Arg Asp Val Gly Thr Leu Glu Ala Tyr Trp Lys Ala Asn Leu 
        275                 280                 285             


Asp Leu Ala Ser Val Val Pro Glu Leu Asp Met Tyr Asp Arg Asn Trp 
    290                 295                 300                 


Pro Ile Arg Thr Tyr Asn Glu Ser Leu Pro Pro Ala Lys Phe Val Gln 
305                 310                 315                 320 


Asp Arg Ser Gly Ser His Gly Met Thr Leu Asn Ser Leu Val Ser Gly 
                325                 330                 335     


Gly Cys Val Ile Ser Gly Ser Val Val Val Gln Ser Val Leu Phe Ser 
            340                 345                 350         


Arg Val Arg Val Asn Ser Phe Cys Asn Ile Asp Ser Ala Val Leu Leu 
        355                 360                 365             


Pro Glu Val Trp Val Gly Arg Ser Cys Arg Leu Arg Arg Cys Val Ile 
    370                 375                 380                 


Asp Arg Ala Cys Val Ile Pro Glu Gly Met Val Ile Gly Glu Asn Ala 
385                 390                 395                 400 


Glu Glu Asp Ala Arg Arg Phe Tyr Arg Ser Glu Glu Gly Ile Val Leu 
                405                 410                 415     


Val Thr Arg Glu Met Leu Arg Lys Leu Gly His Lys Gln Glu Arg 
            420                 425                 430     


<210>  29
<211>  1227
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  CDS
<222>  (1)..(1227)
<223>  Cornebacterium glutamicum (ATCC 13032) Glucose-1-phosphate 
       adenylyltransferase (codon optimized)

<400>  29
atg gtg aag gga gtt aag gga agg cct aat gtt ttg gca ata gtt ctg         48
Met Val Lys Gly Val Lys Gly Arg Pro Asn Val Leu Ala Ile Val Leu           
1               5                   10                  15                

gcg ggt gga gag ggg aaa cgg ttg ttc ccg ctc acc gag gac cgc gcc         96
Ala Gly Gly Glu Gly Lys Arg Leu Phe Pro Leu Thr Glu Asp Arg Ala           
            20                  25                  30                    

aag ccc gcg gtg ccg ttc ggc ggc acc tac cgc ctg atc gat ttc gtg        144
Lys Pro Ala Val Pro Phe Gly Gly Thr Tyr Arg Leu Ile Asp Phe Val           
        35                  40                  45                        

ctg tcc aat ctg gtc aat tcg ggt ttc ctc aag atc gcg gtc ctc acg        192
Leu Ser Asn Leu Val Asn Ser Gly Phe Leu Lys Ile Ala Val Leu Thr           
    50                  55                  60                            

cag tac aag agc cat agc ctt gac cgg cat atc tcc ctg tcc tgg aac        240
Gln Tyr Lys Ser His Ser Leu Asp Arg His Ile Ser Leu Ser Trp Asn           
65                  70                  75                  80            

gtg tcc ggg ccg acg ggc cag tac atc gcc tcc gtc cca gct cag cag        288
Val Ser Gly Pro Thr Gly Gln Tyr Ile Ala Ser Val Pro Ala Gln Gln           
                85                  90                  95                

cgg ctc ggc aag cgc tgg ttc acc ggc tcg gcc gac gcc atc ctg cag        336
Arg Leu Gly Lys Arg Trp Phe Thr Gly Ser Ala Asp Ala Ile Leu Gln           
            100                 105                 110                   

agc ctc aac ctg atc tcc gac gag aag ccc gac tat gtc atc gtg ttt        384
Ser Leu Asn Leu Ile Ser Asp Glu Lys Pro Asp Tyr Val Ile Val Phe           
        115                 120                 125                       

ggc gcg gac cac gtg tac cgg atg gat ccc tcc cag atg ctg gat gag        432
Gly Ala Asp His Val Tyr Arg Met Asp Pro Ser Gln Met Leu Asp Glu           
    130                 135                 140                           

cat atc gcg agt ggt cgc gct gtg tcg gtc gcc ggc atc cgc gtc ccg        480
His Ile Ala Ser Gly Arg Ala Val Ser Val Ala Gly Ile Arg Val Pro           
145                 150                 155                 160           

cgc gaa gag gcg acg gcg ttc ggc tgc atc cag tcc gat gtg gac ggg        528
Arg Glu Glu Ala Thr Ala Phe Gly Cys Ile Gln Ser Asp Val Asp Gly           
                165                 170                 175               

aac atc acc gag ttc ctc gaa aaa ccc gcc gac ccc ccg ggg acc ccg        576
Asn Ile Thr Glu Phe Leu Glu Lys Pro Ala Asp Pro Pro Gly Thr Pro           
            180                 185                 190                   

gac gac ccc gac atg acc tat gcc agc atg ggc aac tac atc ttc acg        624
Asp Asp Pro Asp Met Thr Tyr Ala Ser Met Gly Asn Tyr Ile Phe Thr           
        195                 200                 205                       

acc gaa gca ctg atc caa gcg ctt aaa gat gat gag aat aac gaa aat        672
Thr Glu Ala Leu Ile Gln Ala Leu Lys Asp Asp Glu Asn Asn Glu Asn           
    210                 215                 220                           

tcg gac cat gac atg ggc ggc gac atc att ccg tat ttc gtg tcg cgc        720
Ser Asp His Asp Met Gly Gly Asp Ile Ile Pro Tyr Phe Val Ser Arg           
225                 230                 235                 240           

aac gac gcg cat gtc tac gac ttt tcc ggt aac atc gtg ccg ggt gcg        768
Asn Asp Ala His Val Tyr Asp Phe Ser Gly Asn Ile Val Pro Gly Ala           
                245                 250                 255               

act gag cgc gac aag ggc tat tgg cgc gac gtc ggt acc att gat gcg        816
Thr Glu Arg Asp Lys Gly Tyr Trp Arg Asp Val Gly Thr Ile Asp Ala           
            260                 265                 270                   

ttc tac gag tgc cac atg gac ctg atc tcg gtc cac ccg atc ttc aat        864
Phe Tyr Glu Cys His Met Asp Leu Ile Ser Val His Pro Ile Phe Asn           
        275                 280                 285                       

ctg tat aac agc gag tgg ccg atc cac acc acg tcc gag ggc aac ctc        912
Leu Tyr Asn Ser Glu Trp Pro Ile His Thr Thr Ser Glu Gly Asn Leu           
    290                 295                 300                           

ccg ccg gcc aag ttc gtc cgc ggc ggc ata gcc caa tcg tcg atg gtg        960
Pro Pro Ala Lys Phe Val Arg Gly Gly Ile Ala Gln Ser Ser Met Val           
305                 310                 315                 320           

agc tcc ggc agc atc atc tcg gct ggc acc gtg agg aat agc gtg ctc       1008
Ser Ser Gly Ser Ile Ile Ser Ala Gly Thr Val Arg Asn Ser Val Leu           
                325                 330                 335               

tcg aat aat gtc gtc gtc gag gag ggc gcc acg gtc gag ggc gcg gtg       1056
Ser Asn Asn Val Val Val Glu Glu Gly Ala Thr Val Glu Gly Ala Val           
            340                 345                 350                   

ctc atg ccc ggt gtc cgg att ggc aag ggt gcc gtc gtg cgc cat gca       1104
Leu Met Pro Gly Val Arg Ile Gly Lys Gly Ala Val Val Arg His Ala           
        355                 360                 365                       

att ctc gac aaa aac gtc gtc gtg cgc gac ggc gag ctc atc ggc gtg       1152
Ile Leu Asp Lys Asn Val Val Val Arg Asp Gly Glu Leu Ile Gly Val           
    370                 375                 380                           

gat cag gtc cgg gac gcc cag cgc ttc aag gtc agt gcg ggc gga gtg       1200
Asp Gln Val Arg Asp Ala Gln Arg Phe Lys Val Ser Ala Gly Gly Val           
385                 390                 395                 400           

gtc gtg gtc ggc aag aac caa gtc gtg                                   1227
Val Val Val Gly Lys Asn Gln Val Val                                       
                405                                                       


<210>  30
<211>  409
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  30

Met Val Lys Gly Val Lys Gly Arg Pro Asn Val Leu Ala Ile Val Leu 
1               5                   10                  15      


Ala Gly Gly Glu Gly Lys Arg Leu Phe Pro Leu Thr Glu Asp Arg Ala 
            20                  25                  30          


Lys Pro Ala Val Pro Phe Gly Gly Thr Tyr Arg Leu Ile Asp Phe Val 
        35                  40                  45              


Leu Ser Asn Leu Val Asn Ser Gly Phe Leu Lys Ile Ala Val Leu Thr 
    50                  55                  60                  


Gln Tyr Lys Ser His Ser Leu Asp Arg His Ile Ser Leu Ser Trp Asn 
65                  70                  75                  80  


Val Ser Gly Pro Thr Gly Gln Tyr Ile Ala Ser Val Pro Ala Gln Gln 
                85                  90                  95      


Arg Leu Gly Lys Arg Trp Phe Thr Gly Ser Ala Asp Ala Ile Leu Gln 
            100                 105                 110         


Ser Leu Asn Leu Ile Ser Asp Glu Lys Pro Asp Tyr Val Ile Val Phe 
        115                 120                 125             


Gly Ala Asp His Val Tyr Arg Met Asp Pro Ser Gln Met Leu Asp Glu 
    130                 135                 140                 


His Ile Ala Ser Gly Arg Ala Val Ser Val Ala Gly Ile Arg Val Pro 
145                 150                 155                 160 


Arg Glu Glu Ala Thr Ala Phe Gly Cys Ile Gln Ser Asp Val Asp Gly 
                165                 170                 175     


Asn Ile Thr Glu Phe Leu Glu Lys Pro Ala Asp Pro Pro Gly Thr Pro 
            180                 185                 190         


Asp Asp Pro Asp Met Thr Tyr Ala Ser Met Gly Asn Tyr Ile Phe Thr 
        195                 200                 205             


Thr Glu Ala Leu Ile Gln Ala Leu Lys Asp Asp Glu Asn Asn Glu Asn 
    210                 215                 220                 


Ser Asp His Asp Met Gly Gly Asp Ile Ile Pro Tyr Phe Val Ser Arg 
225                 230                 235                 240 


Asn Asp Ala His Val Tyr Asp Phe Ser Gly Asn Ile Val Pro Gly Ala 
                245                 250                 255     


Thr Glu Arg Asp Lys Gly Tyr Trp Arg Asp Val Gly Thr Ile Asp Ala 
            260                 265                 270         


Phe Tyr Glu Cys His Met Asp Leu Ile Ser Val His Pro Ile Phe Asn 
        275                 280                 285             


Leu Tyr Asn Ser Glu Trp Pro Ile His Thr Thr Ser Glu Gly Asn Leu 
    290                 295                 300                 


Pro Pro Ala Lys Phe Val Arg Gly Gly Ile Ala Gln Ser Ser Met Val 
305                 310                 315                 320 


Ser Ser Gly Ser Ile Ile Ser Ala Gly Thr Val Arg Asn Ser Val Leu 
                325                 330                 335     


Ser Asn Asn Val Val Val Glu Glu Gly Ala Thr Val Glu Gly Ala Val 
            340                 345                 350         


Leu Met Pro Gly Val Arg Ile Gly Lys Gly Ala Val Val Arg His Ala 
        355                 360                 365             


Ile Leu Asp Lys Asn Val Val Val Arg Asp Gly Glu Leu Ile Gly Val 
    370                 375                 380                 


Asp Gln Val Arg Asp Ala Gln Arg Phe Lys Val Ser Ala Gly Gly Val 
385                 390                 395                 400 


Val Val Val Gly Lys Asn Gln Val Val 
                405                 


<210>  31
<211>  1431
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  CDS
<222>  (1)..(1431)
<223>  Escherichia coli str. K-12 substr. W3110 Glycogen Synthase (codon
       optimized)

<400>  31
atg caa gtt ctt cat gtg tgt tcc gaa atg ttc ccc ctc ctc aaa acc         48
Met Gln Val Leu His Val Cys Ser Glu Met Phe Pro Leu Leu Lys Thr           
1               5                   10                  15                

ggt ggc ctg gct gat gtc ata ggt gcc ctg ccg gct gcg cag att gcg         96
Gly Gly Leu Ala Asp Val Ile Gly Ala Leu Pro Ala Ala Gln Ile Ala           
            20                  25                  30                    

gac ggc gtg gac gca cgg gtc ctg ctg ccg gcg ttc ccg gat atc cgc        144
Asp Gly Val Asp Ala Arg Val Leu Leu Pro Ala Phe Pro Asp Ile Arg           
        35                  40                  45                        

cgg ggc gtg acc gac gca caa gtc gtg tcg cgc agg gac acc ttt gcc        192
Arg Gly Val Thr Asp Ala Gln Val Val Ser Arg Arg Asp Thr Phe Ala           
    50                  55                  60                            

ggc cac atc acg ctc ttg ttc ggc cac tat aac ggc gtg ggc atc tac        240
Gly His Ile Thr Leu Leu Phe Gly His Tyr Asn Gly Val Gly Ile Tyr           
65                  70                  75                  80            

ctg atc gat gcg ccg cat ctc tat gac agg ccg ggt tcg ccc tat cat        288
Leu Ile Asp Ala Pro His Leu Tyr Asp Arg Pro Gly Ser Pro Tyr His           
                85                  90                  95                

gac acg aac ctc ttc gcc tac acg gac aat gtg ctg cgg ttc gca ctt        336
Asp Thr Asn Leu Phe Ala Tyr Thr Asp Asn Val Leu Arg Phe Ala Leu           
            100                 105                 110                   

ctg ggc tgg gtc gga gcc gag atg gca tcc ggc ctc gac ccg ttc tgg        384
Leu Gly Trp Val Gly Ala Glu Met Ala Ser Gly Leu Asp Pro Phe Trp           
        115                 120                 125                       

cgc cct gac gtc gtc cat gcg cat gac tgg cat gcc ggc ctc gca ccc        432
Arg Pro Asp Val Val His Ala His Asp Trp His Ala Gly Leu Ala Pro           
    130                 135                 140                           

gcg tat ttg gcc gcc cgg gga cgg ccg gct aag agc gtg ttt acc gtt        480
Ala Tyr Leu Ala Ala Arg Gly Arg Pro Ala Lys Ser Val Phe Thr Val           
145                 150                 155                 160           

cat aac ctc gcg tat cag ggc atg ttc tac gcc cat cac atg aat gat        528
His Asn Leu Ala Tyr Gln Gly Met Phe Tyr Ala His His Met Asn Asp           
                165                 170                 175               

atc cag ctg ccc tgg tcc ttc ttc aac atc cac ggt ctt gag ttc aat        576
Ile Gln Leu Pro Trp Ser Phe Phe Asn Ile His Gly Leu Glu Phe Asn           
            180                 185                 190                   

ggc caa atc tcg ttc ctg aag gcc ggg ctg tac tac gcg gac cac atc        624
Gly Gln Ile Ser Phe Leu Lys Ala Gly Leu Tyr Tyr Ala Asp His Ile           
        195                 200                 205                       

acc gcg gtg tcg cca acc tac gcc cgc gag atc acc gag ccg cag ttc        672
Thr Ala Val Ser Pro Thr Tyr Ala Arg Glu Ile Thr Glu Pro Gln Phe           
    210                 215                 220                           

gcg tac ggc atg gag ggc ctg ctg caa cag cgc cac cgc gag ggc cgg        720
Ala Tyr Gly Met Glu Gly Leu Leu Gln Gln Arg His Arg Glu Gly Arg           
225                 230                 235                 240           

ctc agc ggc gtt ctg aac ggc gtc gac gag aaa atc tgg tcg ccc gag        768
Leu Ser Gly Val Leu Asn Gly Val Asp Glu Lys Ile Trp Ser Pro Glu           
                245                 250                 255               

act gac ttg ctc ctt gcc agc cgc tat acc cgc gac acg ctc gaa gat        816
Thr Asp Leu Leu Leu Ala Ser Arg Tyr Thr Arg Asp Thr Leu Glu Asp           
            260                 265                 270                   

aaa gcc gag aat aag cgc cag ctg cag atc gcc atg ggc ctg aaa gtc        864
Lys Ala Glu Asn Lys Arg Gln Leu Gln Ile Ala Met Gly Leu Lys Val           
        275                 280                 285                       

gac gac aag gtc ccc ctc ttc gcc gtg gtc agc cgc ctg acc tcg caa        912
Asp Asp Lys Val Pro Leu Phe Ala Val Val Ser Arg Leu Thr Ser Gln           
    290                 295                 300                           

aag ggc ctg gac ctg gtg ctc gaa gcc ctc cct ggc ctg ctt gaa cag        960
Lys Gly Leu Asp Leu Val Leu Glu Ala Leu Pro Gly Leu Leu Glu Gln           
305                 310                 315                 320           

ggt ggc cag ttg gcg ctc ctc ggc gcc ggg gat ccg gtg ttg cag gag       1008
Gly Gly Gln Leu Ala Leu Leu Gly Ala Gly Asp Pro Val Leu Gln Glu           
                325                 330                 335               

gga ttc ctg gcg gct gcg gcc gag tat ccg ggc cag gtc ggc gtc cag       1056
Gly Phe Leu Ala Ala Ala Ala Glu Tyr Pro Gly Gln Val Gly Val Gln           
            340                 345                 350                   

att ggc tac cat gaa gcg ttc agt cat cgg atc atg ggt ggg gcc gac       1104
Ile Gly Tyr His Glu Ala Phe Ser His Arg Ile Met Gly Gly Ala Asp           
        355                 360                 365                       

gtc atc ctc gtg ccg tcc cgc ttc gag ccg tgc ggc ctc acc cag ctg       1152
Val Ile Leu Val Pro Ser Arg Phe Glu Pro Cys Gly Leu Thr Gln Leu           
    370                 375                 380                           

tac ggc ctc aag tac gga acg ctc ccc ctg gtg cgg cgg acc ggt ggg       1200
Tyr Gly Leu Lys Tyr Gly Thr Leu Pro Leu Val Arg Arg Thr Gly Gly           
385                 390                 395                 400           

ctc gcc gac acc gtc agc gac tgc tcc ctg gag aac ctg gcg gat ggc       1248
Leu Ala Asp Thr Val Ser Asp Cys Ser Leu Glu Asn Leu Ala Asp Gly           
                405                 410                 415               

gtc gcg agc ggt ttt gtg ttc gag gac agc aac gcc tgg tcg ctg ctc       1296
Val Ala Ser Gly Phe Val Phe Glu Asp Ser Asn Ala Trp Ser Leu Leu           
            420                 425                 430                   

cgc gcg atc cgc agg gcc ttc gtc ctg tgg agt cgc ccg tcc ctc tgg       1344
Arg Ala Ile Arg Arg Ala Phe Val Leu Trp Ser Arg Pro Ser Leu Trp           
        435                 440                 445                       

cgc ttc gtg cag cgg cag gca atg gcc atg gac ttc tcg tgg caa gtc       1392
Arg Phe Val Gln Arg Gln Ala Met Ala Met Asp Phe Ser Trp Gln Val           
    450                 455                 460                           

gcg gcc aag tcc tat cgc gag ctc tac tat cgc ctg aag                   1431
Ala Ala Lys Ser Tyr Arg Glu Leu Tyr Tyr Arg Leu Lys                       
465                 470                 475                               


<210>  32
<211>  477
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  32

Met Gln Val Leu His Val Cys Ser Glu Met Phe Pro Leu Leu Lys Thr 
1               5                   10                  15      


Gly Gly Leu Ala Asp Val Ile Gly Ala Leu Pro Ala Ala Gln Ile Ala 
            20                  25                  30          


Asp Gly Val Asp Ala Arg Val Leu Leu Pro Ala Phe Pro Asp Ile Arg 
        35                  40                  45              


Arg Gly Val Thr Asp Ala Gln Val Val Ser Arg Arg Asp Thr Phe Ala 
    50                  55                  60                  


Gly His Ile Thr Leu Leu Phe Gly His Tyr Asn Gly Val Gly Ile Tyr 
65                  70                  75                  80  


Leu Ile Asp Ala Pro His Leu Tyr Asp Arg Pro Gly Ser Pro Tyr His 
                85                  90                  95      


Asp Thr Asn Leu Phe Ala Tyr Thr Asp Asn Val Leu Arg Phe Ala Leu 
            100                 105                 110         


Leu Gly Trp Val Gly Ala Glu Met Ala Ser Gly Leu Asp Pro Phe Trp 
        115                 120                 125             


Arg Pro Asp Val Val His Ala His Asp Trp His Ala Gly Leu Ala Pro 
    130                 135                 140                 


Ala Tyr Leu Ala Ala Arg Gly Arg Pro Ala Lys Ser Val Phe Thr Val 
145                 150                 155                 160 


His Asn Leu Ala Tyr Gln Gly Met Phe Tyr Ala His His Met Asn Asp 
                165                 170                 175     


Ile Gln Leu Pro Trp Ser Phe Phe Asn Ile His Gly Leu Glu Phe Asn 
            180                 185                 190         


Gly Gln Ile Ser Phe Leu Lys Ala Gly Leu Tyr Tyr Ala Asp His Ile 
        195                 200                 205             


Thr Ala Val Ser Pro Thr Tyr Ala Arg Glu Ile Thr Glu Pro Gln Phe 
    210                 215                 220                 


Ala Tyr Gly Met Glu Gly Leu Leu Gln Gln Arg His Arg Glu Gly Arg 
225                 230                 235                 240 


Leu Ser Gly Val Leu Asn Gly Val Asp Glu Lys Ile Trp Ser Pro Glu 
                245                 250                 255     


Thr Asp Leu Leu Leu Ala Ser Arg Tyr Thr Arg Asp Thr Leu Glu Asp 
            260                 265                 270         


Lys Ala Glu Asn Lys Arg Gln Leu Gln Ile Ala Met Gly Leu Lys Val 
        275                 280                 285             


Asp Asp Lys Val Pro Leu Phe Ala Val Val Ser Arg Leu Thr Ser Gln 
    290                 295                 300                 


Lys Gly Leu Asp Leu Val Leu Glu Ala Leu Pro Gly Leu Leu Glu Gln 
305                 310                 315                 320 


Gly Gly Gln Leu Ala Leu Leu Gly Ala Gly Asp Pro Val Leu Gln Glu 
                325                 330                 335     


Gly Phe Leu Ala Ala Ala Ala Glu Tyr Pro Gly Gln Val Gly Val Gln 
            340                 345                 350         


Ile Gly Tyr His Glu Ala Phe Ser His Arg Ile Met Gly Gly Ala Asp 
        355                 360                 365             


Val Ile Leu Val Pro Ser Arg Phe Glu Pro Cys Gly Leu Thr Gln Leu 
    370                 375                 380                 


Tyr Gly Leu Lys Tyr Gly Thr Leu Pro Leu Val Arg Arg Thr Gly Gly 
385                 390                 395                 400 


Leu Ala Asp Thr Val Ser Asp Cys Ser Leu Glu Asn Leu Ala Asp Gly 
                405                 410                 415     


Val Ala Ser Gly Phe Val Phe Glu Asp Ser Asn Ala Trp Ser Leu Leu 
            420                 425                 430         


Arg Ala Ile Arg Arg Ala Phe Val Leu Trp Ser Arg Pro Ser Leu Trp 
        435                 440                 445             


Arg Phe Val Gln Arg Gln Ala Met Ala Met Asp Phe Ser Trp Gln Val 
    450                 455                 460                 


Ala Ala Lys Ser Tyr Arg Glu Leu Tyr Tyr Arg Leu Lys 
465                 470                 475         


<210>  33
<211>  1227
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  CDS
<222>  (1)..(1227)
<223>  Cornebacterium glutamicum (ATCC 13032)  Glycosyltransferase 
       (codon optimized)

<400>  33
atg cca cct ttc cgc tat cgc tgt gct act gtt ttc cgc tgg ttg att         48
Met Pro Pro Phe Arg Tyr Arg Cys Ala Thr Val Phe Arg Trp Leu Ile           
1               5                   10                  15                

ttt gaa ata atg cgc gtc ggg atg atg acc cgc gag tac ccg cct gaa         96
Phe Glu Ile Met Arg Val Gly Met Met Thr Arg Glu Tyr Pro Pro Glu           
            20                  25                  30                    

gtg tac ggt gga gcc ggg gtc cat gtg acc gag ctt acc cgg ttc atg        144
Val Tyr Gly Gly Ala Gly Val His Val Thr Glu Leu Thr Arg Phe Met           
        35                  40                  45                        

cgc gag atc gca gag gtc gac gtg cac tgc atg ggc gca ccg cgc gac        192
Arg Glu Ile Ala Glu Val Asp Val His Cys Met Gly Ala Pro Arg Asp           
    50                  55                  60                            

atg gag ggt gtt ttc gtg cac ggc gtc gac ccg gca ctc gaa tcg gcg        240
Met Glu Gly Val Phe Val His Gly Val Asp Pro Ala Leu Glu Ser Ala           
65                  70                  75                  80            

aac ccc gcc atc aag acg ctc tcg acg ggc ctg cgg atg gcc gag gcc        288
Asn Pro Ala Ile Lys Thr Leu Ser Thr Gly Leu Arg Met Ala Glu Ala           
                85                  90                  95                

gcg aat aat gtt gac gtc gtg cat tcg cat acc tgg tat gcg ggc ctg        336
Ala Asn Asn Val Asp Val Val His Ser His Thr Trp Tyr Ala Gly Leu           
            100                 105                 110                   

ggt ggc cat ctc gcg gcc agg ctg cac ggc atc ccg cat gtg gcg acg        384
Gly Gly His Leu Ala Ala Arg Leu His Gly Ile Pro His Val Ala Thr           
        115                 120                 125                       

gcg cat agc ctg gag ccg gac cgg ccc tgg aag cgc gag caa ctc ggc        432
Ala His Ser Leu Glu Pro Asp Arg Pro Trp Lys Arg Glu Gln Leu Gly           
    130                 135                 140                           

ggc ggc tac gac gtg agc tcc tgg tcg gag aaa aac gcg atg gag tac        480
Gly Gly Tyr Asp Val Ser Ser Trp Ser Glu Lys Asn Ala Met Glu Tyr           
145                 150                 155                 160           

gcg gac gcc gtg atc gcc gtc agt gcc cgg atg aaa gac tcc atc ctg        528
Ala Asp Ala Val Ile Ala Val Ser Ala Arg Met Lys Asp Ser Ile Leu           
                165                 170                 175               

gcg gct tat ccg cgc atc gag ccc gat aat gtg cgc gtg gtg ctg aac        576
Ala Ala Tyr Pro Arg Ile Glu Pro Asp Asn Val Arg Val Val Leu Asn           
            180                 185                 190                   

ggc atc gac acc gag ctc tgg cag ccg agg ccg acc ttc gac gac gcc        624
Gly Ile Asp Thr Glu Leu Trp Gln Pro Arg Pro Thr Phe Asp Asp Ala           
        195                 200                 205                       

gag gat tcc gtg ctg cgc agc ctg ggc gtc gac ccg caa cgg ccc atc        672
Glu Asp Ser Val Leu Arg Ser Leu Gly Val Asp Pro Gln Arg Pro Ile           
    210                 215                 220                           

gtc gcg ttt gtc gga cgg att acg cgg cag aaa ggc gtg gag cac ctc        720
Val Ala Phe Val Gly Arg Ile Thr Arg Gln Lys Gly Val Glu His Leu           
225                 230                 235                 240           

atc aaa gcc gcc gcc ctg ttc gac gag tcc gtc cag ctc gtc ctc tgc        768
Ile Lys Ala Ala Ala Leu Phe Asp Glu Ser Val Gln Leu Val Leu Cys           
                245                 250                 255               

gcg ggt gcc ccc gac acc ccg gag atc gcg gct cgg acc acg gcg ctg        816
Ala Gly Ala Pro Asp Thr Pro Glu Ile Ala Ala Arg Thr Thr Ala Leu           
            260                 265                 270                   

gtc gag gaa ctc caa gcg aag cgc gag ggc atc ttc tgg gtc cag gat        864
Val Glu Glu Leu Gln Ala Lys Arg Glu Gly Ile Phe Trp Val Gln Asp           
        275                 280                 285                       

atg ctg ggg aag gat aag atc cag gag atc ctc acc gcc gct gac acc        912
Met Leu Gly Lys Asp Lys Ile Gln Glu Ile Leu Thr Ala Ala Asp Thr           
    290                 295                 300                           

ttc gtg tgc ccg tcg atc tat gag ccc ctg ggc atc gtc aac ctc gaa        960
Phe Val Cys Pro Ser Ile Tyr Glu Pro Leu Gly Ile Val Asn Leu Glu           
305                 310                 315                 320           

gcc atg gcg tgc aat acc gcc gtg gtc gcg agc gac gtc ggc ggc atc       1008
Ala Met Ala Cys Asn Thr Ala Val Val Ala Ser Asp Val Gly Gly Ile           
                325                 330                 335               

cca gag gtc gtc gtg gac ggc acc acg ggc gca ctg gtg cat tac gat       1056
Pro Glu Val Val Val Asp Gly Thr Thr Gly Ala Leu Val His Tyr Asp           
            340                 345                 350                   

gag aac gat gtg gaa acg ttc gag cgc gac att gcc gaa gcc gtg aac       1104
Glu Asn Asp Val Glu Thr Phe Glu Arg Asp Ile Ala Glu Ala Val Asn           
        355                 360                 365                       

aag atg gtc gcg gat cgc gag act gcc gcg aag ttc ggt ctt gca ggc       1152
Lys Met Val Ala Asp Arg Glu Thr Ala Ala Lys Phe Gly Leu Ala Gly           
    370                 375                 380                           

cgg gag cgg gcg atc aat gac ttc agc tgg gcc acc atc gcc cag cag       1200
Arg Glu Arg Ala Ile Asn Asp Phe Ser Trp Ala Thr Ile Ala Gln Gln           
385                 390                 395                 400           

acc atc gac gtc tat aag tcg ctg atg                                   1227
Thr Ile Asp Val Tyr Lys Ser Leu Met                                       
                405                                                       


<210>  34
<211>  409
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  34

Met Pro Pro Phe Arg Tyr Arg Cys Ala Thr Val Phe Arg Trp Leu Ile 
1               5                   10                  15      


Phe Glu Ile Met Arg Val Gly Met Met Thr Arg Glu Tyr Pro Pro Glu 
            20                  25                  30          


Val Tyr Gly Gly Ala Gly Val His Val Thr Glu Leu Thr Arg Phe Met 
        35                  40                  45              


Arg Glu Ile Ala Glu Val Asp Val His Cys Met Gly Ala Pro Arg Asp 
    50                  55                  60                  


Met Glu Gly Val Phe Val His Gly Val Asp Pro Ala Leu Glu Ser Ala 
65                  70                  75                  80  


Asn Pro Ala Ile Lys Thr Leu Ser Thr Gly Leu Arg Met Ala Glu Ala 
                85                  90                  95      


Ala Asn Asn Val Asp Val Val His Ser His Thr Trp Tyr Ala Gly Leu 
            100                 105                 110         


Gly Gly His Leu Ala Ala Arg Leu His Gly Ile Pro His Val Ala Thr 
        115                 120                 125             


Ala His Ser Leu Glu Pro Asp Arg Pro Trp Lys Arg Glu Gln Leu Gly 
    130                 135                 140                 


Gly Gly Tyr Asp Val Ser Ser Trp Ser Glu Lys Asn Ala Met Glu Tyr 
145                 150                 155                 160 


Ala Asp Ala Val Ile Ala Val Ser Ala Arg Met Lys Asp Ser Ile Leu 
                165                 170                 175     


Ala Ala Tyr Pro Arg Ile Glu Pro Asp Asn Val Arg Val Val Leu Asn 
            180                 185                 190         


Gly Ile Asp Thr Glu Leu Trp Gln Pro Arg Pro Thr Phe Asp Asp Ala 
        195                 200                 205             


Glu Asp Ser Val Leu Arg Ser Leu Gly Val Asp Pro Gln Arg Pro Ile 
    210                 215                 220                 


Val Ala Phe Val Gly Arg Ile Thr Arg Gln Lys Gly Val Glu His Leu 
225                 230                 235                 240 


Ile Lys Ala Ala Ala Leu Phe Asp Glu Ser Val Gln Leu Val Leu Cys 
                245                 250                 255     


Ala Gly Ala Pro Asp Thr Pro Glu Ile Ala Ala Arg Thr Thr Ala Leu 
            260                 265                 270         


Val Glu Glu Leu Gln Ala Lys Arg Glu Gly Ile Phe Trp Val Gln Asp 
        275                 280                 285             


Met Leu Gly Lys Asp Lys Ile Gln Glu Ile Leu Thr Ala Ala Asp Thr 
    290                 295                 300                 


Phe Val Cys Pro Ser Ile Tyr Glu Pro Leu Gly Ile Val Asn Leu Glu 
305                 310                 315                 320 


Ala Met Ala Cys Asn Thr Ala Val Val Ala Ser Asp Val Gly Gly Ile 
                325                 330                 335     


Pro Glu Val Val Val Asp Gly Thr Thr Gly Ala Leu Val His Tyr Asp 
            340                 345                 350         


Glu Asn Asp Val Glu Thr Phe Glu Arg Asp Ile Ala Glu Ala Val Asn 
        355                 360                 365             


Lys Met Val Ala Asp Arg Glu Thr Ala Ala Lys Phe Gly Leu Ala Gly 
    370                 375                 380                 


Arg Glu Arg Ala Ile Asn Asp Phe Ser Trp Ala Thr Ile Ala Gln Gln 
385                 390                 395                 400 


Thr Ile Asp Val Tyr Lys Ser Leu Met 
                405                 


<210>  35
<211>  2184
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  CDS
<222>  (1)..(2184)
<223>  E. coli  1,4-alpha-glucan branching enzyme (Acc.No. YP 492001.1) 
       (codon optimized)

<400>  35
atg tcc gac cgc att gat agg gac gtc ata aat gca ctg atc gct ggc         48
Met Ser Asp Arg Ile Asp Arg Asp Val Ile Asn Ala Leu Ile Ala Gly           
1               5                   10                  15                

cac ttt gct gac ccg ttc tcc gtt ctg ggc atg cat aag acc acc gcc         96
His Phe Ala Asp Pro Phe Ser Val Leu Gly Met His Lys Thr Thr Ala           
            20                  25                  30                    

ggt ctg gag gtc cgc gcg ctg ctg ccc gac gcg acc gac gtc tgg gtc        144
Gly Leu Glu Val Arg Ala Leu Leu Pro Asp Ala Thr Asp Val Trp Val           
        35                  40                  45                        

atc gag ccc aag act ggc cgc aaa ctg gcg aaa ctt gag tgc ctc gac        192
Ile Glu Pro Lys Thr Gly Arg Lys Leu Ala Lys Leu Glu Cys Leu Asp           
    50                  55                  60                            

agc cgg gga ttc ttt agc ggc gtg atc ccg cgg cgg aag aac ttc ttt        240
Ser Arg Gly Phe Phe Ser Gly Val Ile Pro Arg Arg Lys Asn Phe Phe           
65                  70                  75                  80            

agg tat caa ctc gcc gtc gtg tgg cat ggg cag cag aac ctg atc gat        288
Arg Tyr Gln Leu Ala Val Val Trp His Gly Gln Gln Asn Leu Ile Asp           
                85                  90                  95                

gat ccc tac agg ttc ggt ccc ttg atc caa gag atg gat gcg tgg ctg        336
Asp Pro Tyr Arg Phe Gly Pro Leu Ile Gln Glu Met Asp Ala Trp Leu           
            100                 105                 110                   

ctc tcc gag ggc acc cac ctc cgc ccg tac gag act ctc ggg gca cat        384
Leu Ser Glu Gly Thr His Leu Arg Pro Tyr Glu Thr Leu Gly Ala His           
        115                 120                 125                       

gcg gac acg atg gac ggc gtg acg ggc acc cgc ttc tcg gtc tgg gct        432
Ala Asp Thr Met Asp Gly Val Thr Gly Thr Arg Phe Ser Val Trp Ala           
    130                 135                 140                           

ccg aat gca cgc cgg gtg tcc gtg gtc gga cag ttc aat tac tgg gat        480
Pro Asn Ala Arg Arg Val Ser Val Val Gly Gln Phe Asn Tyr Trp Asp           
145                 150                 155                 160           

ggt cgg cgc cac ccc atg cgg ctg cgg aag gaa tcg ggt atc tgg gag        528
Gly Arg Arg His Pro Met Arg Leu Arg Lys Glu Ser Gly Ile Trp Glu           
                165                 170                 175               

ttg ttc atc cca ggc gcc cat aac ggg cag ctc tac aaa tac gaa atg        576
Leu Phe Ile Pro Gly Ala His Asn Gly Gln Leu Tyr Lys Tyr Glu Met           
            180                 185                 190                   

atc gat gcg aat ggc aac ctc cgg ctg aaa agt gac ccg tat gcc ttc        624
Ile Asp Ala Asn Gly Asn Leu Arg Leu Lys Ser Asp Pro Tyr Ala Phe           
        195                 200                 205                       

gaa gcg cag atg cgc ccc gaa acg gcg tcc ctg atc tgc ggc ctc cct        672
Glu Ala Gln Met Arg Pro Glu Thr Ala Ser Leu Ile Cys Gly Leu Pro           
    210                 215                 220                           

gaa aaa gtc gtc cag acc gag gaa cgc aag aag gcc aac caa ttc gac        720
Glu Lys Val Val Gln Thr Glu Glu Arg Lys Lys Ala Asn Gln Phe Asp           
225                 230                 235                 240           

gcg ccg atc tcg atc tat gag gtc cac ctg ggc tcg tgg cgc agg cac        768
Ala Pro Ile Ser Ile Tyr Glu Val His Leu Gly Ser Trp Arg Arg His           
                245                 250                 255               

acc gac aac aat ttc tgg ctc tcg tac cgc gag ctg gcg gac caa ctc        816
Thr Asp Asn Asn Phe Trp Leu Ser Tyr Arg Glu Leu Ala Asp Gln Leu           
            260                 265                 270                   

gtg ccg tat gct aag tgg atg gga ttc acg cat ttg gaa ctg ctg ccg        864
Val Pro Tyr Ala Lys Trp Met Gly Phe Thr His Leu Glu Leu Leu Pro           
        275                 280                 285                       

atc aac gaa cat ccc ttc gac ggc agc tgg ggc tat cag ccg acc ggc        912
Ile Asn Glu His Pro Phe Asp Gly Ser Trp Gly Tyr Gln Pro Thr Gly           
    290                 295                 300                           

ctc tac gcc ccg act cgc cgg ttc ggc acg cgg gat gac ttc cgg tac        960
Leu Tyr Ala Pro Thr Arg Arg Phe Gly Thr Arg Asp Asp Phe Arg Tyr           
305                 310                 315                 320           

ttc atc gat gcc gcg cat gcc gcc ggc ctc aac gtc atc ctg gac tgg       1008
Phe Ile Asp Ala Ala His Ala Ala Gly Leu Asn Val Ile Leu Asp Trp           
                325                 330                 335               

gtg ccc ggt cac ttt ccc acc gac gac ttc gcg ctg gcc gag ttc gac       1056
Val Pro Gly His Phe Pro Thr Asp Asp Phe Ala Leu Ala Glu Phe Asp           
            340                 345                 350                   

ggc acc aac ctc tac gag cat agt gat ccg cgc gag ggc tac cat cag       1104
Gly Thr Asn Leu Tyr Glu His Ser Asp Pro Arg Glu Gly Tyr His Gln           
        355                 360                 365                       

gac tgg aac acg ctc atc tac aat tac ggt cgc cgc gag gtc agc aac       1152
Asp Trp Asn Thr Leu Ile Tyr Asn Tyr Gly Arg Arg Glu Val Ser Asn           
    370                 375                 380                           

ttc ctg gtt ggg aat gcg ctg tat tgg att gag cgc ttc ggc ata gac       1200
Phe Leu Val Gly Asn Ala Leu Tyr Trp Ile Glu Arg Phe Gly Ile Asp           
385                 390                 395                 400           

gcc ctg cgc gtc gac gcc gtg gca tcc atg atc tac cgc gat tat tcc       1248
Ala Leu Arg Val Asp Ala Val Ala Ser Met Ile Tyr Arg Asp Tyr Ser           
                405                 410                 415               

cgc aaa gag ggc gag tgg atc ccc aat gag ttc ggt ggc cgc gag aac       1296
Arg Lys Glu Gly Glu Trp Ile Pro Asn Glu Phe Gly Gly Arg Glu Asn           
            420                 425                 430                   

ctt gag gcc att gag ttc ctt agg aat acg aac cgg atc ctg ggg gaa       1344
Leu Glu Ala Ile Glu Phe Leu Arg Asn Thr Asn Arg Ile Leu Gly Glu           
        435                 440                 445                       

caa gtg tcc ggg gct gtc acc atg gca gag gag agc acc gat ttt ccc       1392
Gln Val Ser Gly Ala Val Thr Met Ala Glu Glu Ser Thr Asp Phe Pro           
    450                 455                 460                           

ggc gtg tcg cgc ccg caa gac atg ggt ggc ctg ggc ttc tgg tac aag       1440
Gly Val Ser Arg Pro Gln Asp Met Gly Gly Leu Gly Phe Trp Tyr Lys           
465                 470                 475                 480           

tgg aat ctg ggc tgg atg cac gac acc ctc gac tac atg aag ctt gat       1488
Trp Asn Leu Gly Trp Met His Asp Thr Leu Asp Tyr Met Lys Leu Asp           
                485                 490                 495               

ccg gtc tat cgc cag tat cac cat gac aag ctc acg ttc ggc atc ctg       1536
Pro Val Tyr Arg Gln Tyr His His Asp Lys Leu Thr Phe Gly Ile Leu           
            500                 505                 510                   

tat aac tat acc gag aat ttc gtg ctc ccg ttg agc cat gac gaa gtt       1584
Tyr Asn Tyr Thr Glu Asn Phe Val Leu Pro Leu Ser His Asp Glu Val           
        515                 520                 525                       

gtc cat ggc aag aag agt att ctg gac cgg atg cca ggc gac gcg tgg       1632
Val His Gly Lys Lys Ser Ile Leu Asp Arg Met Pro Gly Asp Ala Trp           
    530                 535                 540                           

cag aaa ttc gcg aat ctc cgc gcc tat tat ggc tgg atg tgg gcg ttc       1680
Gln Lys Phe Ala Asn Leu Arg Ala Tyr Tyr Gly Trp Met Trp Ala Phe           
545                 550                 555                 560           

ccg ggc aaa aag ctc ctg ttc atg gga aat gag ttc gcc cag ggc cgg       1728
Pro Gly Lys Lys Leu Leu Phe Met Gly Asn Glu Phe Ala Gln Gly Arg           
                565                 570                 575               

gag tgg aac cat gac gcg agc ctc gac tgg cat ctc ctt gag ggc gga       1776
Glu Trp Asn His Asp Ala Ser Leu Asp Trp His Leu Leu Glu Gly Gly           
            580                 585                 590                   

gac aac tgg cac cac ggc gtg cag cgc ctc gtg cgg gac ctc aac ctg       1824
Asp Asn Trp His His Gly Val Gln Arg Leu Val Arg Asp Leu Asn Leu           
        595                 600                 605                       

acc tac cgc cat cat aaa gcc atg cac gag ctg gat ttc gac ccg tac       1872
Thr Tyr Arg His His Lys Ala Met His Glu Leu Asp Phe Asp Pro Tyr           
    610                 615                 620                           

ggc ttc gag tgg ctc gtc gtc gac gat aag gag cgc tcg gtc ctc att       1920
Gly Phe Glu Trp Leu Val Val Asp Asp Lys Glu Arg Ser Val Leu Ile           
625                 630                 635                 640           

ttc gtg cgc agg gac aag gaa ggc aac gag atc atc gtg gcg agc aac       1968
Phe Val Arg Arg Asp Lys Glu Gly Asn Glu Ile Ile Val Ala Ser Asn           
                645                 650                 655               

ttc acc ccg gtc ccg cgg cac gac tac cgc ttc ggc atc aat cag ccg       2016
Phe Thr Pro Val Pro Arg His Asp Tyr Arg Phe Gly Ile Asn Gln Pro           
            660                 665                 670                   

ggc aag tgg cgc gag atc ctg aac acg gac tcg atg cat tat cat ggt       2064
Gly Lys Trp Arg Glu Ile Leu Asn Thr Asp Ser Met His Tyr His Gly           
        675                 680                 685                       

tcg aac gcc ggg aat ggc ggc acc gtg cac tcg gac gag atc gcc tcc       2112
Ser Asn Ala Gly Asn Gly Gly Thr Val His Ser Asp Glu Ile Ala Ser           
    690                 695                 700                           

cat ggc cgc cag cat agc ttg tcc ctg acc ctg ccc cct ctc gcg acc       2160
His Gly Arg Gln His Ser Leu Ser Leu Thr Leu Pro Pro Leu Ala Thr           
705                 710                 715                 720           

atc tgg ctg gtg cgc gag gcc gag                                       2184
Ile Trp Leu Val Arg Glu Ala Glu                                           
                725                                                       


<210>  36
<211>  728
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  36

Met Ser Asp Arg Ile Asp Arg Asp Val Ile Asn Ala Leu Ile Ala Gly 
1               5                   10                  15      


His Phe Ala Asp Pro Phe Ser Val Leu Gly Met His Lys Thr Thr Ala 
            20                  25                  30          


Gly Leu Glu Val Arg Ala Leu Leu Pro Asp Ala Thr Asp Val Trp Val 
        35                  40                  45              


Ile Glu Pro Lys Thr Gly Arg Lys Leu Ala Lys Leu Glu Cys Leu Asp 
    50                  55                  60                  


Ser Arg Gly Phe Phe Ser Gly Val Ile Pro Arg Arg Lys Asn Phe Phe 
65                  70                  75                  80  


Arg Tyr Gln Leu Ala Val Val Trp His Gly Gln Gln Asn Leu Ile Asp 
                85                  90                  95      


Asp Pro Tyr Arg Phe Gly Pro Leu Ile Gln Glu Met Asp Ala Trp Leu 
            100                 105                 110         


Leu Ser Glu Gly Thr His Leu Arg Pro Tyr Glu Thr Leu Gly Ala His 
        115                 120                 125             


Ala Asp Thr Met Asp Gly Val Thr Gly Thr Arg Phe Ser Val Trp Ala 
    130                 135                 140                 


Pro Asn Ala Arg Arg Val Ser Val Val Gly Gln Phe Asn Tyr Trp Asp 
145                 150                 155                 160 


Gly Arg Arg His Pro Met Arg Leu Arg Lys Glu Ser Gly Ile Trp Glu 
                165                 170                 175     


Leu Phe Ile Pro Gly Ala His Asn Gly Gln Leu Tyr Lys Tyr Glu Met 
            180                 185                 190         


Ile Asp Ala Asn Gly Asn Leu Arg Leu Lys Ser Asp Pro Tyr Ala Phe 
        195                 200                 205             


Glu Ala Gln Met Arg Pro Glu Thr Ala Ser Leu Ile Cys Gly Leu Pro 
    210                 215                 220                 


Glu Lys Val Val Gln Thr Glu Glu Arg Lys Lys Ala Asn Gln Phe Asp 
225                 230                 235                 240 


Ala Pro Ile Ser Ile Tyr Glu Val His Leu Gly Ser Trp Arg Arg His 
                245                 250                 255     


Thr Asp Asn Asn Phe Trp Leu Ser Tyr Arg Glu Leu Ala Asp Gln Leu 
            260                 265                 270         


Val Pro Tyr Ala Lys Trp Met Gly Phe Thr His Leu Glu Leu Leu Pro 
        275                 280                 285             


Ile Asn Glu His Pro Phe Asp Gly Ser Trp Gly Tyr Gln Pro Thr Gly 
    290                 295                 300                 


Leu Tyr Ala Pro Thr Arg Arg Phe Gly Thr Arg Asp Asp Phe Arg Tyr 
305                 310                 315                 320 


Phe Ile Asp Ala Ala His Ala Ala Gly Leu Asn Val Ile Leu Asp Trp 
                325                 330                 335     


Val Pro Gly His Phe Pro Thr Asp Asp Phe Ala Leu Ala Glu Phe Asp 
            340                 345                 350         


Gly Thr Asn Leu Tyr Glu His Ser Asp Pro Arg Glu Gly Tyr His Gln 
        355                 360                 365             


Asp Trp Asn Thr Leu Ile Tyr Asn Tyr Gly Arg Arg Glu Val Ser Asn 
    370                 375                 380                 


Phe Leu Val Gly Asn Ala Leu Tyr Trp Ile Glu Arg Phe Gly Ile Asp 
385                 390                 395                 400 


Ala Leu Arg Val Asp Ala Val Ala Ser Met Ile Tyr Arg Asp Tyr Ser 
                405                 410                 415     


Arg Lys Glu Gly Glu Trp Ile Pro Asn Glu Phe Gly Gly Arg Glu Asn 
            420                 425                 430         


Leu Glu Ala Ile Glu Phe Leu Arg Asn Thr Asn Arg Ile Leu Gly Glu 
        435                 440                 445             


Gln Val Ser Gly Ala Val Thr Met Ala Glu Glu Ser Thr Asp Phe Pro 
    450                 455                 460                 


Gly Val Ser Arg Pro Gln Asp Met Gly Gly Leu Gly Phe Trp Tyr Lys 
465                 470                 475                 480 


Trp Asn Leu Gly Trp Met His Asp Thr Leu Asp Tyr Met Lys Leu Asp 
                485                 490                 495     


Pro Val Tyr Arg Gln Tyr His His Asp Lys Leu Thr Phe Gly Ile Leu 
            500                 505                 510         


Tyr Asn Tyr Thr Glu Asn Phe Val Leu Pro Leu Ser His Asp Glu Val 
        515                 520                 525             


Val His Gly Lys Lys Ser Ile Leu Asp Arg Met Pro Gly Asp Ala Trp 
    530                 535                 540                 


Gln Lys Phe Ala Asn Leu Arg Ala Tyr Tyr Gly Trp Met Trp Ala Phe 
545                 550                 555                 560 


Pro Gly Lys Lys Leu Leu Phe Met Gly Asn Glu Phe Ala Gln Gly Arg 
                565                 570                 575     


Glu Trp Asn His Asp Ala Ser Leu Asp Trp His Leu Leu Glu Gly Gly 
            580                 585                 590         


Asp Asn Trp His His Gly Val Gln Arg Leu Val Arg Asp Leu Asn Leu 
        595                 600                 605             


Thr Tyr Arg His His Lys Ala Met His Glu Leu Asp Phe Asp Pro Tyr 
    610                 615                 620                 


Gly Phe Glu Trp Leu Val Val Asp Asp Lys Glu Arg Ser Val Leu Ile 
625                 630                 635                 640 


Phe Val Arg Arg Asp Lys Glu Gly Asn Glu Ile Ile Val Ala Ser Asn 
                645                 650                 655     


Phe Thr Pro Val Pro Arg His Asp Tyr Arg Phe Gly Ile Asn Gln Pro 
            660                 665                 670         


Gly Lys Trp Arg Glu Ile Leu Asn Thr Asp Ser Met His Tyr His Gly 
        675                 680                 685             


Ser Asn Ala Gly Asn Gly Gly Thr Val His Ser Asp Glu Ile Ala Ser 
    690                 695                 700                 


His Gly Arg Gln His Ser Leu Ser Leu Thr Leu Pro Pro Leu Ala Thr 
705                 710                 715                 720 


Ile Trp Leu Val Arg Glu Ala Glu 
                725             


<210>  37
<211>  2193
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  CDS
<222>  (1)..(2193)
<223>  Corynebacterium glutamicum  (ATCC 13032) Glycogen branching 
       enzyme (codon optimized)

<400>  37
atg acc gtc gac ccc gcg tcc cat atc acg atc ccc gaa gcc gac ctc         48
Met Thr Val Asp Pro Ala Ser His Ile Thr Ile Pro Glu Ala Asp Leu           
1               5                   10                  15                

gca cgc ctc cgc cac tgc aac cat cac gac ccc cat gga ttc tac ggg         96
Ala Arg Leu Arg His Cys Asn His His Asp Pro His Gly Phe Tyr Gly           
            20                  25                  30                    

tgg cat gaa act gag gcc ggg tcc gtc att cgc acc cgc cag gtc ggc        144
Trp His Glu Thr Glu Ala Gly Ser Val Ile Arg Thr Arg Gln Val Gly           
        35                  40                  45                        

gcg acc cag gtg aat ctg ctc att gat gac acg agc cat gtc atg acg        192
Ala Thr Gln Val Asn Leu Leu Ile Asp Asp Thr Ser His Val Met Thr           
    50                  55                  60                            

ccc atc ggc gac gac atc ttc gcg atc gac ctc ggg cat cgg gag cgc        240
Pro Ile Gly Asp Asp Ile Phe Ala Ile Asp Leu Gly His Arg Glu Arg           
65                  70                  75                  80            

gct gat tac cgc ctt gag gtc acg tgg ccg gac caa gag cca cag gtg        288
Ala Asp Tyr Arg Leu Glu Val Thr Trp Pro Asp Gln Glu Pro Gln Val           
                85                  90                  95                

aaa gct gac ccg tac tat ttc ctc ccc acg gtc ggt gag atg gac atc        336
Lys Ala Asp Pro Tyr Tyr Phe Leu Pro Thr Val Gly Glu Met Asp Ile           
            100                 105                 110                   

tat ctg ttc tcc gag ggt cgg cac gaa cgg ctc tgg gag atc ctc ggc        384
Tyr Leu Phe Ser Glu Gly Arg His Glu Arg Leu Trp Glu Ile Leu Gly           
        115                 120                 125                       

gcc aat atc aag acc tat cag acc gcg ctg ggc acc gtc cgc ggc acg        432
Ala Asn Ile Lys Thr Tyr Gln Thr Ala Leu Gly Thr Val Arg Gly Thr           
    130                 135                 140                           

gcg ttc acc gtc tgg gca ccc aac gcg atc ggc tgc gcg gtc gtg ggg        480
Ala Phe Thr Val Trp Ala Pro Asn Ala Ile Gly Cys Ala Val Val Gly           
145                 150                 155                 160           

ggc ttc aac ggt tgg aac gcc agt caa cac ccg atg cgg agc atg ggc        528
Gly Phe Asn Gly Trp Asn Ala Ser Gln His Pro Met Arg Ser Met Gly           
                165                 170                 175               

gga tcc ggc ctt tgg gag ctg ttc atc ccg ggc atc gag gag ggc gag        576
Gly Ser Gly Leu Trp Glu Leu Phe Ile Pro Gly Ile Glu Glu Gly Glu           
            180                 185                 190                   

gtg tac aag ttt gcg gtg cag acc cgc gaa ggc cag cgc agg gat aag        624
Val Tyr Lys Phe Ala Val Gln Thr Arg Glu Gly Gln Arg Arg Asp Lys           
        195                 200                 205                       

gcc gac ccc atg gcg cgg cgc gcc gag ctg gca cca gcc acc ggc agc        672
Ala Asp Pro Met Ala Arg Arg Ala Glu Leu Ala Pro Ala Thr Gly Ser           
    210                 215                 220                           

ata gtt gcc tcg tcc gag tac cag tgg cag gac tcc gag tgg ctg cgc        720
Ile Val Ala Ser Ser Glu Tyr Gln Trp Gln Asp Ser Glu Trp Leu Arg           
225                 230                 235                 240           

gag cgg agc cag act gac ctc gcc agc aag cct atg tcc gtg tat gag        768
Glu Arg Ser Gln Thr Asp Leu Ala Ser Lys Pro Met Ser Val Tyr Glu           
                245                 250                 255               

gtg cat ctg ggt tcg tgg cgc tgg ggc aag aac tac gaa gat ctg gcg        816
Val His Leu Gly Ser Trp Arg Trp Gly Lys Asn Tyr Glu Asp Leu Ala           
            260                 265                 270                   

acc gag ctc gtc gat tat gtt gcg gac ctg ggt tat acg cat gtc gag        864
Thr Glu Leu Val Asp Tyr Val Ala Asp Leu Gly Tyr Thr His Val Glu           
        275                 280                 285                       

ttc ctg ccg gtg gcg gag cac ccg ttc ggc ggc tcg tgg ggc tac caa        912
Phe Leu Pro Val Ala Glu His Pro Phe Gly Gly Ser Trp Gly Tyr Gln           
    290                 295                 300                           

gtc acg ggt tat tac gcg ccg acc agc cgc tgg ggc acc ccg gac cag        960
Val Thr Gly Tyr Tyr Ala Pro Thr Ser Arg Trp Gly Thr Pro Asp Gln           
305                 310                 315                 320           

ttc cgc gcg ttg gtc gac gcg ttc cac gcc agg gga atc ggc gtc atc       1008
Phe Arg Ala Leu Val Asp Ala Phe His Ala Arg Gly Ile Gly Val Ile           
                325                 330                 335               

atg gac tgg gtt ccc gca cat ttc ccg aaa gat gat tgg gcg ctg gcg       1056
Met Asp Trp Val Pro Ala His Phe Pro Lys Asp Asp Trp Ala Leu Ala           
            340                 345                 350                   

cgg ttc gac ggc gag gcc ctc tat gag cac ccg gac tgg cgg cgg ggt       1104
Arg Phe Asp Gly Glu Ala Leu Tyr Glu His Pro Asp Trp Arg Arg Gly           
        355                 360                 365                       

gag cag aaa gat tgg ggg acc ctc gtg ttc gat ttt ggc cgg aac gaa       1152
Glu Gln Lys Asp Trp Gly Thr Leu Val Phe Asp Phe Gly Arg Asn Glu           
    370                 375                 380                           

gtc cgc aac ttc ttg gtc gcg aac gcg ctc tat tgg att gaa gag ttc       1200
Val Arg Asn Phe Leu Val Ala Asn Ala Leu Tyr Trp Ile Glu Glu Phe           
385                 390                 395                 400           

cat att gac ggc ctc cgg gtc gac gcc gtc gcc tcg atg ctc tac ctg       1248
His Ile Asp Gly Leu Arg Val Asp Ala Val Ala Ser Met Leu Tyr Leu           
                405                 410                 415               

gac tac tcg cgc gag cac ggc gag tgg gag ccg aac atc tat ggc gga       1296
Asp Tyr Ser Arg Glu His Gly Glu Trp Glu Pro Asn Ile Tyr Gly Gly           
            420                 425                 430                   

cgg gag aat ctc gaa gcc gtc cag ttc ctg caa gag atg aac gca acc       1344
Arg Glu Asn Leu Glu Ala Val Gln Phe Leu Gln Glu Met Asn Ala Thr           
        435                 440                 445                       

gtg ctc cgc ctg cat cct ggt gcg ctg acc atc gca gag gaa tcg acc       1392
Val Leu Arg Leu His Pro Gly Ala Leu Thr Ile Ala Glu Glu Ser Thr           
    450                 455                 460                           

tcg tgg ccg ggt gtg acc gct ccg acc tgg gac ggt ggc ctt ggt ttc       1440
Ser Trp Pro Gly Val Thr Ala Pro Thr Trp Asp Gly Gly Leu Gly Phe           
465                 470                 475                 480           

agc ctg aag tgg aat atg ggc tgg atg cat gac acc ctt gag tat ttc       1488
Ser Leu Lys Trp Asn Met Gly Trp Met His Asp Thr Leu Glu Tyr Phe           
                485                 490                 495               

tcg aag aat ccg gtg cac agg gcc ttc cac cat tcc gag ctg acg ttc       1536
Ser Lys Asn Pro Val His Arg Ala Phe His His Ser Glu Leu Thr Phe           
            500                 505                 510                   

tcg ctt gtc tac gcc ttc agt gag cgc ttc gtg ctg ccg atc tcc cat       1584
Ser Leu Val Tyr Ala Phe Ser Glu Arg Phe Val Leu Pro Ile Ser His           
        515                 520                 525                       

gac gaa gtc gtc cac ggc aag ggc tcc ctg tgg gac cgg atg ccg ggt       1632
Asp Glu Val Val His Gly Lys Gly Ser Leu Trp Asp Arg Met Pro Gly           
    530                 535                 540                           

gac acc tgg aat aaa gcc gca ggc ctc cgc acg ttc ctg gcg tac atg       1680
Asp Thr Trp Asn Lys Ala Ala Gly Leu Arg Thr Phe Leu Ala Tyr Met           
545                 550                 555                 560           

tgg agc cac ccg ggc aag aaa ctg ctg ttc atg ggc caa gag ttc ggc       1728
Trp Ser His Pro Gly Lys Lys Leu Leu Phe Met Gly Gln Glu Phe Gly           
                565                 570                 575               

cag cgc gag gag tgg gcc gag ggc cag ggc ctg ccc tgg gac atc gtg       1776
Gln Arg Glu Glu Trp Ala Glu Gly Gln Gly Leu Pro Trp Asp Ile Val           
            580                 585                 590                   

gac ggg tgg cag ggc gag tat cat gaa gcg atc cgc acc ctc acg cgc       1824
Asp Gly Trp Gln Gly Glu Tyr His Glu Ala Ile Arg Thr Leu Thr Arg           
        595                 600                 605                       

agc ctg aac ggc gtg tac agc gat agt ccg gcg ctc cat acc caa gat       1872
Ser Leu Asn Gly Val Tyr Ser Asp Ser Pro Ala Leu His Thr Gln Asp           
    610                 615                 620                           

ttc acc ggc gag ggc ttc acg tgg aac aaa ggt gac gac gcc acc aat       1920
Phe Thr Gly Glu Gly Phe Thr Trp Asn Lys Gly Asp Asp Ala Thr Asn           
625                 630                 635                 640           

aac atc ctc gcc ttc acc cgc ttt ggc tcc gac ggc tcg cag atg ctc       1968
Asn Ile Leu Ala Phe Thr Arg Phe Gly Ser Asp Gly Ser Gln Met Leu           
                645                 650                 655               

tgc gtg ttc aac ctc tcg ggc acc tcg cag ccg gag tac cag ctc ggg       2016
Cys Val Phe Asn Leu Ser Gly Thr Ser Gln Pro Glu Tyr Gln Leu Gly           
            660                 665                 670                   

gtg gcc gct ggg ggc gag tgg aag ctt gtg ctg aat acc gac gac gcc       2064
Val Ala Ala Gly Gly Glu Trp Lys Leu Val Leu Asn Thr Asp Asp Ala           
        675                 680                 685                       

gag ttt ttg gga gcc gaa aac gat atc gcg acg agc gtg caa gct gct       2112
Glu Phe Leu Gly Ala Glu Asn Asp Ile Ala Thr Ser Val Gln Ala Ala           
    690                 695                 700                           

gcc act ccc agg gac aat ttc gcc tat tcc ctg agc ctg cat gtc ccc       2160
Ala Thr Pro Arg Asp Asn Phe Ala Tyr Ser Leu Ser Leu His Val Pro           
705                 710                 715                 720           

gcc atg tcg gcg cag ttc tac tcg ctc cag aag                           2193
Ala Met Ser Ala Gln Phe Tyr Ser Leu Gln Lys                               
                725                 730                                   


<210>  38
<211>  731
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  38

Met Thr Val Asp Pro Ala Ser His Ile Thr Ile Pro Glu Ala Asp Leu 
1               5                   10                  15      


Ala Arg Leu Arg His Cys Asn His His Asp Pro His Gly Phe Tyr Gly 
            20                  25                  30          


Trp His Glu Thr Glu Ala Gly Ser Val Ile Arg Thr Arg Gln Val Gly 
        35                  40                  45              


Ala Thr Gln Val Asn Leu Leu Ile Asp Asp Thr Ser His Val Met Thr 
    50                  55                  60                  


Pro Ile Gly Asp Asp Ile Phe Ala Ile Asp Leu Gly His Arg Glu Arg 
65                  70                  75                  80  


Ala Asp Tyr Arg Leu Glu Val Thr Trp Pro Asp Gln Glu Pro Gln Val 
                85                  90                  95      


Lys Ala Asp Pro Tyr Tyr Phe Leu Pro Thr Val Gly Glu Met Asp Ile 
            100                 105                 110         


Tyr Leu Phe Ser Glu Gly Arg His Glu Arg Leu Trp Glu Ile Leu Gly 
        115                 120                 125             


Ala Asn Ile Lys Thr Tyr Gln Thr Ala Leu Gly Thr Val Arg Gly Thr 
    130                 135                 140                 


Ala Phe Thr Val Trp Ala Pro Asn Ala Ile Gly Cys Ala Val Val Gly 
145                 150                 155                 160 


Gly Phe Asn Gly Trp Asn Ala Ser Gln His Pro Met Arg Ser Met Gly 
                165                 170                 175     


Gly Ser Gly Leu Trp Glu Leu Phe Ile Pro Gly Ile Glu Glu Gly Glu 
            180                 185                 190         


Val Tyr Lys Phe Ala Val Gln Thr Arg Glu Gly Gln Arg Arg Asp Lys 
        195                 200                 205             


Ala Asp Pro Met Ala Arg Arg Ala Glu Leu Ala Pro Ala Thr Gly Ser 
    210                 215                 220                 


Ile Val Ala Ser Ser Glu Tyr Gln Trp Gln Asp Ser Glu Trp Leu Arg 
225                 230                 235                 240 


Glu Arg Ser Gln Thr Asp Leu Ala Ser Lys Pro Met Ser Val Tyr Glu 
                245                 250                 255     


Val His Leu Gly Ser Trp Arg Trp Gly Lys Asn Tyr Glu Asp Leu Ala 
            260                 265                 270         


Thr Glu Leu Val Asp Tyr Val Ala Asp Leu Gly Tyr Thr His Val Glu 
        275                 280                 285             


Phe Leu Pro Val Ala Glu His Pro Phe Gly Gly Ser Trp Gly Tyr Gln 
    290                 295                 300                 


Val Thr Gly Tyr Tyr Ala Pro Thr Ser Arg Trp Gly Thr Pro Asp Gln 
305                 310                 315                 320 


Phe Arg Ala Leu Val Asp Ala Phe His Ala Arg Gly Ile Gly Val Ile 
                325                 330                 335     


Met Asp Trp Val Pro Ala His Phe Pro Lys Asp Asp Trp Ala Leu Ala 
            340                 345                 350         


Arg Phe Asp Gly Glu Ala Leu Tyr Glu His Pro Asp Trp Arg Arg Gly 
        355                 360                 365             


Glu Gln Lys Asp Trp Gly Thr Leu Val Phe Asp Phe Gly Arg Asn Glu 
    370                 375                 380                 


Val Arg Asn Phe Leu Val Ala Asn Ala Leu Tyr Trp Ile Glu Glu Phe 
385                 390                 395                 400 


His Ile Asp Gly Leu Arg Val Asp Ala Val Ala Ser Met Leu Tyr Leu 
                405                 410                 415     


Asp Tyr Ser Arg Glu His Gly Glu Trp Glu Pro Asn Ile Tyr Gly Gly 
            420                 425                 430         


Arg Glu Asn Leu Glu Ala Val Gln Phe Leu Gln Glu Met Asn Ala Thr 
        435                 440                 445             


Val Leu Arg Leu His Pro Gly Ala Leu Thr Ile Ala Glu Glu Ser Thr 
    450                 455                 460                 


Ser Trp Pro Gly Val Thr Ala Pro Thr Trp Asp Gly Gly Leu Gly Phe 
465                 470                 475                 480 


Ser Leu Lys Trp Asn Met Gly Trp Met His Asp Thr Leu Glu Tyr Phe 
                485                 490                 495     


Ser Lys Asn Pro Val His Arg Ala Phe His His Ser Glu Leu Thr Phe 
            500                 505                 510         


Ser Leu Val Tyr Ala Phe Ser Glu Arg Phe Val Leu Pro Ile Ser His 
        515                 520                 525             


Asp Glu Val Val His Gly Lys Gly Ser Leu Trp Asp Arg Met Pro Gly 
    530                 535                 540                 


Asp Thr Trp Asn Lys Ala Ala Gly Leu Arg Thr Phe Leu Ala Tyr Met 
545                 550                 555                 560 


Trp Ser His Pro Gly Lys Lys Leu Leu Phe Met Gly Gln Glu Phe Gly 
                565                 570                 575     


Gln Arg Glu Glu Trp Ala Glu Gly Gln Gly Leu Pro Trp Asp Ile Val 
            580                 585                 590         


Asp Gly Trp Gln Gly Glu Tyr His Glu Ala Ile Arg Thr Leu Thr Arg 
        595                 600                 605             


Ser Leu Asn Gly Val Tyr Ser Asp Ser Pro Ala Leu His Thr Gln Asp 
    610                 615                 620                 


Phe Thr Gly Glu Gly Phe Thr Trp Asn Lys Gly Asp Asp Ala Thr Asn 
625                 630                 635                 640 


Asn Ile Leu Ala Phe Thr Arg Phe Gly Ser Asp Gly Ser Gln Met Leu 
                645                 650                 655     


Cys Val Phe Asn Leu Ser Gly Thr Ser Gln Pro Glu Tyr Gln Leu Gly 
            660                 665                 670         


Val Ala Ala Gly Gly Glu Trp Lys Leu Val Leu Asn Thr Asp Asp Ala 
        675                 680                 685             


Glu Phe Leu Gly Ala Glu Asn Asp Ile Ala Thr Ser Val Gln Ala Ala 
    690                 695                 700                 


Ala Thr Pro Arg Asp Asn Phe Ala Tyr Ser Leu Ser Leu His Val Pro 
705                 710                 715                 720 


Ala Met Ser Ala Gln Phe Tyr Ser Leu Gln Lys 
                725                 730     


