                         SEQUENCE LISTING

<110>  ROSEN, Michael R.
       BOINK, Gerard J.
       TAN, Hanno L.
       ROBINSON, Richard B.
       COHEN, Ira S.
       BRINK, Peter R.
       DANILO, Peter Jr.
 
<120>  BIOLOGICAL PACEMAKERS INCORORATING HCN2 AND SkM1 GENES

<130>  P4715PC00

<150>  US 61/927,018
<151>  2014-01-14

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  3372
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(3372)
<223>  Human HCN2

<400>  1
cggctccgct ccgcactgcc cggcgccgcc tcgccatgga cgcgcgcggg ggcggcgggc       60

ggcccgggga gagcccgggc gcgagcccca cgaccgggcc gccgccgccg ccgcccccgc      120

gcccccccaa acagcagccg ccgccgccgc cgccgcccgc gccccccccg ggccccgggc      180

ccgcgccccc ccagcacccg ccccgggccg aggcgttgcc cccggaggcg gcggatgagg      240

gcggcccgcg gggccggctc cgcagccgcg acagctcgtg cggccgcccc ggcaccccgg      300

gcgcggcgag cacggccaag ggcagcccga acggcgagtg cgggcgcggc gagccgcagt      360

gcagccccgc ggggcccgag ggcccggcgc gggggcccaa ggtgtcgttc tcgtgccgcg      420

gggcggcctc ggggcccgcg ccggggccgg ggccggcgga ggaggcgggc agcgaggagg      480

cgggcccggc gggggagccg cgcggcagcc aggccagctt catgcagcgc cagttcggcg      540

cgctcctgca gccgggcgtc aacaagttct cgctgcggat gttcggcagc cagaaggccg      600

tggagcgcga gcaggagcgc gtcaagtcgg cgggggcctg gatcatccac ccgtacagcg      660

acttcaggtt ctactgggac ttcaccatgc tgctgttcat ggtgggaaac ctcatcatca      720

tcccagtggg catcaccttc ttcaaggatg agaccactgc cccgtggatc gtgttcaacg      780

tggtctcgga caccttcttc ctcatggacc tggtgttgaa cttccgcacc ggcattgtga      840

tcgaggacaa cacggagatc atcctggacc ccgagaagat caagaagaag tatctgcgca      900

cgtggttcgt ggtggacttc gtgtcctcca tccccgtgga ctacatcttc cttatcgtgg      960

agaagggcat tgactccgag gtctacaaga cggcacgcgc cctgcgcatc gtgcgcttca     1020

ccaagatcct cagcctcctg cggctgctgc gcctctcacg cctgatccgc tacatccatc     1080

agtgggagga gatcttccac atgacctatg acctggccag cgcggtgatg aggatctgca     1140

atctcatcag catgatgctg ctgctctgcc actgggacgg ctgcctgcag ttcctggtgc     1200

ctatgctgca ggacttcccg cgcaactgct gggtgtccat caatggcatg gtgaaccact     1260

cgtggagtga actgtactcc ttcgcactct tcaaggccat gagccacatg ctgtgcatcg     1320

ggtacggccg gcaggcgccc gagagcatga cggacatctg gctgaccatg ctcagcatga     1380

ttgtgggtgc cacctgctac gccatgttca tcggccacgc cactgccctc atccagtcgc     1440

tggactcctc gcggcgccag taccaggaga agtacaagca ggtggagcag tacatgtcct     1500

tccacaagct gccagctgac ttccgccaga agatccacga ctactatgag caccgttacc     1560

agggcaagat gtttgacgag gacagcatcc tgggcgagct caacgggccc ctgcgggagg     1620

agatcgtcaa cttcaactgc cggaagctgg tggcctccat gccgctgttc gccaacgccg     1680

accccaactt cgtcacggcc atgctgacca agctcaagtt cgaggtcttc cagccgggtg     1740

actacatcat ccgcgaaggc accatcggga agaagatgta cttcatccag cacggcgtgg     1800

tcagcgtgct cactaagggc aacaaggaga tgaagctgtc cgatggctcc tacttcgggg     1860

agatctgcct gctcacccgg ggccgccgca cggcgagcgt gcgggctgac acctactgcc     1920

gcctctattc gctgagcgtg gacaacttca acgaggtgct ggaggagtac cccatgatgc     1980

ggcgcgcctt cgagacggtg gccatcgacc gcctggaccg catcggcaag aagaattcca     2040

tcctcctgca caaggtgcag catgacctca actcgggcgt attcaacaac caggagaacg     2100

ccatcatcca ggagatcgtc aagtacgacc gcgagatggt gcagcaggcc gagctgggtc     2160

agcgcgtggg cctcttcccg ccgccgccgc cgccgccgca ggtcacctcg gccatcgcca     2220

cgctgcagca ggcggcggcc atgagcttct gcccgcaggt ggcgcggccg ctcgtggggc     2280

cgctggcgct cggctcgccg cgcctcgtgc gccgcccgcc cccggggccc gcacctgccg     2340

ccgcctcacc cgggcccccg ccccccgcca gccccccggg cgcgcccgcc agcccccggg     2400

caccgcggac ctcgccctac ggcggcctgc ccgccgcccc ccttgctggg cccgccctgc     2460

ccgcgcgccg cctgagccgc gcgtcgcgcc cactgtccgc ctcgcagccc tcgctgcctc     2520

acggcgcccc cggccccgcg gcctccacac gcccggccag cagctccaca ccgcgcttgg     2580

ggcccacgcc cgctgcccgg gccgccgcgc ccagcccgga ccgcagggac tcggcctcac     2640

ccggcgccgc cggcggcctg gacccccagg actccgcgcg ctcgcgcctc tcgtccaact     2700

tgtgaccctc gccgaccgcc ccgcgggccc aggcgggccg ggggcggggc cgtcatccag     2760

accaaagcca tgccattgcg ctgccccggc cgccagtccg cccagaagcc atagacgaga     2820

cgtaggtagc cgtagttgga cggacgggca gggccggcgg ggcagccccc tccgcgcccc     2880

cggccgtccc ccctcatcgc cccgcgccca cccccatcgc ccctgccccc ggcggcggcc     2940

tcgcgtgcga gggggctccc ttcacctcgg tgcctcagtt cccccagctg taagacaggg     3000

acggggcggc ccagtggctg agaggagccg gctgtggagc cccgcccgcc ccccaccctc     3060

taggtggccc ccgtccgagg aggatcgttt tctaagtgca atacttggcc cgccggcttc     3120

ccgctgcccc catcgcgctc acgcaataac cggcccggcc cccgtccgcg cgcgtccccc     3180

ggtgacctcg gggagcagca ccccgcctcc ctccagcact ggcaccgaga ggcaggcctg     3240

gctgcgcagg gcgcgggggg gaggctgggg tcccgccgcc gtgatgaatg tactgacgag     3300

ccgaggcagc agtgccccca ccgtggcccc ccacgcccca ttaaccccca cacccccatt     3360

ccgcgcaata aa                                                         3372


<210>  2
<211>  809
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(809)
<223>  Human KCNE2

<400>  2
gtaaggtgaa ggtgcccagc aggctgaggc ttgtgtgcaa cccagaagag agctcgctaa       60

cgccagcaag aaggttcaga acagcctggc tttggaaagg aatttcatcc tgcccacaca      120

ctgcatagca ggagggaagc atgtctactt tatccaattt cacacagacg ctggaagacg      180

tcttccgaag gatttttatt acttatatgg acaattggcg ccagaacaca acagctgagc      240

aagaggccct ccaagccaaa gttgatgctg agaacttcta ctatgtcatc ctgtacctca      300

tggtgatgat tggaatgttc tctttcatca tcgtggccat cctggtgagc actgtgaaat      360

ccaagagacg ggaacactcc aatgacccct accaccagta cattgtagag gactggcagg      420

aaaagtacaa gagccaaatc ttgaatctag aagaatcgaa ggccaccatc catgagaaca      480

ttggtgcggc tgggttcaaa atgtccccct gataagggag aaaggcacca agctaacatc      540

tgacgtccag acatgaagag atgccagtgc cacgaggcaa atccaaattg tctttgctta      600

gaagaaagtg agttccttgc tctctgttga gaattttcat ggagattatg tggttggcca      660

ataaagatag atgacatttc aatctcagtg atttatgctt gcttgttgga gcaatatttt      720

gtgctgaaga cctcttttac tttccgggca agtgaatgtc attttaatca atatcaatga      780

tgaaaataaa gccaaatttg aagaaaaaa                                        809


<210>  3
<211>  6957
<212>  DNA
<213>  Rattus norvegicus


<220>
<221>  misc_feature
<222>  (1)..(6957)
<223>  Rat SkM1

<400>  3
acggcacccg gggctcgtcc gccaccgctc ttctctgctt ctggccaaca gctgaagtca       60

cgcagttcct ggagtctgaa cccaggagac agttcgggac actggggcgt tggccccaag      120

ctcctcgggc tggagaagat ctggttcact ttctgttgat cccgaaggtg gcacaatcta      180

ttgctgagaa gagaacactg cggggcctgg agtgggggaa tgcaccgtgc ccagtgtcct      240

gggcatcagc acgcccaggt cttgcaggca catctcccag ccccaacaag accaggacac      300

ccacctccct gacccaactc ctgggcaggc agagagtgag gagtacacag tagaccccgg      360

gcattggtga ccacccaaaa cccaagggct gcgggctgta gcggctctgt tacctaccac      420

cctctggccc ctgagcccag aatgcaagga tggccagctc atctctgccc aacctggtcc      480

ccccgggtcc ccactgcctg cgccccttca ccccagagtc cctggcagcc atagagcagc      540

gggcggtgga ggaggaggcc cggctgcagc ggaacaagca gatggagatt gaggagcctg      600

agcggaagcc acgcagtgac ctggaagctg gcaagaacct cccactcatc tatggggacc      660

ccccacccga agtcattggc atccccctgg aggacctgga tccttactac agtgacaaga      720

agaccttcat tgtgctcaac aaaggaaagg ccatcttccg attctctgcc acgcctgccc      780

tctacctgct gagccccttc agcatcgtca ggagggtggc tatcaaggtg ctcattcacg      840

cgctgttcag catgtttatc atgatcacca tcctgaccaa ctgtgtgttc atgaccatga      900

gcaatccgcc ttcttggtcc aaacacgtgg agtacacctt cacggggatc tatacctttg      960

agtccctcat taagatgctg gcccgaggct tttgcattga tgacttcaca ttcctccgag     1020

acccctggaa ctggctggac ttcagtgtca tcacaatggc gtatgtgaca gagtttgtgg     1080

acttgggcaa catctcagcc ctgaggacct tccgtgtgct gcgggccctg aagaccatca     1140

cggttatccc agggctgaag acaattgtgg gagccctgat ccagtctgtg aaaaagctgt     1200

cggatgtgat gatcctcact gtcttctgcc tgagtgtctt tgccctggtg gggctgcagc     1260

ttttcatggg aaacctgcgt cagaagtgcg tgcgttggcc cccgcccatg aatgacacca     1320

acaccacgtg gtatggcaat gacacttggt acagcaatga cacttggtac ggcaatgaca     1380

cttggtacat caatgacact tggaacagcc aggagagctg ggccggcaac tctacctttg     1440

actgggaggc ctacatcaat gacgaaggga acttctattt cttggagggc tccaatgatg     1500

ctctgctctg tgggaatagc agtgatgctg ggcactgccc tgagggctac gaatgcataa     1560

aggctgggcg gaaccccaac tatggctaca ccagctatga caccttcagc tgggctttcc     1620

tggctctctt ccggctcatg acgcaggact actgggagaa ccttttccag ctgaccctac     1680

gagctgctgg caagacctac atgatcttct tcgtggtcat catcttcctg ggctccttct     1740

acctcatcaa tctgatcctg gccgtggtgg ccatggcgta cgctgagcag aatgaggcta     1800

ccctggccga agaccaggag aaagaggagg agttccaaca gatgcttgag aaatacaaaa     1860

aacatcagga ggaactggaa aaggctaagg ctgcccaggc tctggaaagt ggagaggagg     1920

cagatgggga cccaacccac aacaaagact gcaatgggag cctggatgca tccggggaga     1980

aggggccccc aaggccaagc tgcagcgcag acagtgccat ctcagatgct atggaggagc     2040

tggaagaggc ccatcagaag tgcccaccgt ggtggtacaa gtgtgcacac aaagtcctca     2100

tctggaactg ctgtgccccg tgggtgaagt tcaaacatat aatctacctg atcgtcatgg     2160

acccctttgt ggacctgggt atcaccatct gcattgtgct caacaccctc ttcatggcca     2220

tggagcacta ccccatgacc gagcactttg acaacgtgct ctccgtgggc aacttggtct     2280

tcacaggcat cttcactgcg gagatggtgt tgaagctgat tgccatggac ccctacgagt     2340

atttccaaca gggctggaac atctttgaca gtttcatcgt caccctcagc ctggtggagc     2400

tgggcctggc caacgtacag gggctgtcag tgctccgttc cttccgcctg ctgcgtgtct     2460

tcaagctggc caagtcatgg ccaacactca acatgctcat caaaatcatt ggcaactcag     2520

tgggcgcgct gggcaacctg accctggtgc tggccatcat cgtcttcatc ttcgccgtgg     2580

tgggcatgca gctgttcggc aagagctata aggagtgtgt gtgcaagatc gcctcagact     2640

gcaacctgcc tcgctggcac atgaacgact tcttccactc cttcctcatc gtcttccgca     2700

tcctctgcgg ggaatggatc gagaccatgt gggactgcat ggaggtggcc ggccaggcca     2760

tgtgcctcac cgtcttcctc atggtcatgg tcattggcaa cctggtggtc ctgaatctgt     2820

tcctggctct cctgctgagt tccttcagtg ctgacagcct ggcggcctcg gatgaggatg     2880

gcgagatgaa caacctacag attgccatcg ggcgtatcaa gtggggcatc ggttttgcca     2940

aaaccttcct cctggggctg ttgcgtggca agatcctgag ccccaaggaa ataatactca     3000

gcctcggtga gcccgggggt gccggggaaa atgccgagga gagtactccc gaggatgaga     3060

agaaggagcc gccaccggaa gataaggagc tgaaagacaa tcatatcctg aaccacgtgg     3120

gcctgaccga tggcccccgc tccagcatcg agctggacca ccttaacttc atcaacaacc     3180

cctacctcac catccaggtg cccattgcct ccgaggagtc tgacctggag atgcccacag     3240

aggaggagac agacgccttc tcggagcctg aggatatcaa gaagccccta cagcccctct     3300

acgacgggaa ctcctccgtc tgcagcacag ctgactacaa gccccctgaa gaggaccccg     3360

aggagcaggc tgaggagaac cccgaggggg agcagcctga ggaatgcttc acggaagcct     3420

gtgtgaagcg ctgcccctgc ctctatgtgg acatctccca gggccgtggg aaaatgtggt     3480

ggacactgcg cagggcctgt ttcaagattg ttgagcacaa ctggtttgag accttcattg     3540

tcttcatgat cttgctcagc agtggagccc tggccttcga ggacatctac attgaacagc     3600

gacgagtcat ccgcaccatc ctggaatacg ccgacaaggt cttcacctac atcttcatcc     3660

tggagatgtt gctaaagtgg gtcgcctacg gcttcaaggt gtatttcacc aatgcctggt     3720

gctggctcga cttcctcatc gtggacgtct ccatcatcag cctggtggca aactggctgg     3780

gctactctga gctggggccc atcaaatccc tgcgcacact ccgggccctg cgacctctga     3840

gggcactgtc tcgatttgag ggtatgaggg tggtggtgaa cgccctcctg ggagctatcc     3900

cctccatcat gaacgtcctc ctcgtctgcc tcatcttctg gctcatcttc agcatcatgg     3960

gggtcaactt gtttgctgga aagttctact actgcgtcaa caccaccacc tctgagagat     4020

tcgacatctc ggtggtcaac aacaagtccg agtctgagag cctcatgtat acaggccagg     4080

tccgctggat gaatgtcaag gtcaactacg acaacgtggg tctgggctat ctctccctcc     4140

ttcaggtggc cacattcaag ggttggatgg atatcatgta tgcagctgtg gactcccggg     4200

agaaagagga gcagccacac tatgaggtga acctctacat gtacctctac ttcgtcatct     4260

tcatcatctt cggctccttc ttcaccctca acctcttcat cggtgtcatc atcgacaact     4320

tcaaccaaca gaagaagaag tttggaggga aagacatctt catgacagag gaacagaaga     4380

aatactacaa tgcgatgaag aagcttggct ccaagaagcc ccagaagcca attccccggc     4440

ctcagaacaa gatccagggc atggtgtacg acttcgtgac gaagcaggtg tttgacatct     4500

ccatcatgat cctcatctgc ctcaacatgg ttactatgat ggtggagaca gatgaccaga     4560

gccagctcaa ggtggacatc ctgtacaaca tcaacatggt cttcattatc atcttcacag     4620

gggagtgtgt gctgaagatg tttgccctac gccattacta cttcaccatt ggctggaaca     4680

tctttgactt tgtggttgtc atcttgtcca tcgtgggcct tgcgctctct gacttgatac     4740

agaaatactt tgtgtcaccc acgctgttcc gtgtgatccg cttggctcgg atcgggcgtg     4800

tcctgcgtct gatccgcggg gccaagggca tccggacgct gctgttcgcc ctgatgatgt     4860

ccctgcccgc cctcttcaac atcggcctcc ttctctttct ggtcatgttc atctactcga     4920

tcttcggcat gtctaacttc gcctacgtca agaaagagtc aggcatcgac gacatgttta     4980

actttgagac ctttggcaac agtatcatct gcctcttcga gatcaccacg tcagccggct     5040

gggacgggct tctgaacccc atcctcaaca gtgggccccc agactgtgac ccgacgttgg     5100

agaacccggg taccaatgtc aggggggact gcggcaaccc ttccatcggc atctgtttct     5160

tctgcagcta catcatcatc tccttcctca tcgtggtcaa catgtacatt gctatcatcc     5220

tggagaattt caacgtggcc accgaagaga gcagcgagcc cctcagtgag gatgacttcg     5280

agatgttcta tgagacctgg gagaagttcg acccggacgc cactcagttc atcgactaca     5340

gccgcctctc ggactttgtg gacaccctgc aggagccact gaaaatcgcc aaacccaata     5400

agatcaagct tatcacgtta gacctgccca tggtgcccgg cgacaagatc cactgcttgg     5460

acatcctctt tgccctgacc aaagaggtac tgggtgactc tggggagatg gacgccctca     5520

agcagaccat ggaggagaag tttatggcag ctaacccttc caaggtctcc tatgagccca     5580

tcaccaccac cctcaagagg aagcaggagg aggtgtgtgc tatcaaaatc cagagggcct     5640

accgccgcca cctgctgcag cgctccgtga agcaggcctc ttacatgtac cgtcacagcc     5700

aggacggcaa tgacgacggg gcccccgaga aggagggatt gcttgccaac accatgaaca     5760

agatgtatgg ccatgagaaa gagggtgatg gtgtgcagag ccagggggag gaagagaagg     5820

cctctacaga ggatgctgga cccaccgtgg agcccgaacc caccagcagc tcagatactg     5880

ccctgactcc ttctcctcca ccactacccc cctcatcatc accgccacaa gggcagacag     5940

ttcgcccagg ggtcaaagag tctcttgtct agatggcagc gtcaaggctg cacgcagagt     6000

tggaggggaa gggctttgag atgggggcta tacaggactt gacacctggg ctgaggggta     6060

tggaaattgt gctcagggtt caggtgggtc ggaagcccct gctgcctgat ttcatcttta     6120

cgatgctctg acattctgtt ggccagggga ggccaggaca tctgaatgct gtttccttct     6180

tgggggagag ccagcatacc ttggaggggt tggccacctt cctgtcacta ctttaagggc     6240

ccaggacccc agctctagcc aagacaaaga cgaatcttaa cccccaaacc tacacctgac     6300

ccccagagct tagctatccc tctcgccccc ataattctag ggtgcagctt ccccctgaca     6360

gctcaggaat gccctgtaaa aggggaaatg gttctggtac agaaccaatt ggccgctgga     6420

tccggatgta tcaggctgga aacatgactt ctgaaacctt tcacccagtc agatccaggc     6480

cggtgggcag ctcccctggc tggcccctgg gggaagaact aaggaaggat tgccctgaga     6540

aattaccttt ctctagattg cgtggatggg tcaaacaggc tgggtcctgc cagctgcatt     6600

catgcccttg agcctgagcg cccacatctg cctggggtca ggttggaagc tctctatcaa     6660

gaatcgcccg ttcccgcctc cctgccttct ttctttgaat accagggctc ctgggagccc     6720

catcaaacac gaaagactgc cttcctcctg tctaatctct gcccccccct tccctgcccc     6780

ttccctgctt cctcaagtga ctctgagaat gctagaactc agcacacggg agatgagttg     6840

atactggggc atgcagtgag aaggctcacc aggcttggct ttggtcttct cattgcctga     6900

aagcaagttt tcccctgaga cagggtttct tttctccgtg tagccctggc tgcctgg        6957


<210>  4
<211>  7823
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(7823)
<223>  Human SkM1

<400>  4
ccagcacccc ggggctgcgc actgcagctc cccaggccac ccaccaccct tctggtctct       60

gagcccagga tgcgaggatg gccagaccat ctctgtgcac cctggctcgt ctgggccctg      120

agtgcttgcg ccccttcacc cgggagtcac tggcagccat agaacagcgg gcggtggagg      180

aggaggcccg gctgcagcgg aataagcaga tggagattga ggagcccgaa cggaagccac      240

gaagtgactt ggaggctggc aagaacctac ccatgatcta cggagacccc ccgccggagg      300

tcatcggcat ccccctggag gacctggatc cctactacag caataagaag accttcatcg      360

tactcaacaa gggcaaggcc atcttccgct tctccgccac acctgctctc tacctgctga      420

gccccttcag cgtagtcagg cgcggggcca tcaaggtgct catccatgcg ctgttcagca      480

tgttcatcat gatcaccatc ttgaccaact gcgtattcat gaccatgagt gacccgcctc      540

cctggtccaa gaatgtggag tacaccttca cagggatcta cacctttgag tccctcatca      600

agatactggc ccgaggcttc tgtgtcgacg acttcacatt cctccgggac ccctggaact      660

ggctggactt cagtgtcatc atgatggcgt acctgacaga gtttgtggac ttgggcaaca      720

tctcagccct gaggaccttc cgggtgctgc gggccctcaa aaccatcacg gtcatcccag      780

ggctgaagac gatcgtgggg gccctgatcc agtcggtgaa gaagctgtcg gatgtgatga      840

tcctcactgt cttctgcctg agcgtctttg cgctggtagg actgcagctc ttcatgggaa      900

acctgaggca gaagtgtgtg cgctggcccc cgccgttcaa cgacaccaac accacgtggt      960

acagcaatga cacgtggtac ggcaatgaca catggtatgg caatgagatg tggtacggca     1020

atgactcatg gtatgccaac gacacgtgga acagccatgc aagctgggcc accaacgata     1080

cctttgattg ggacgcctac atcagtgatg aagggaactt ctacttcctg gagggctcca     1140

acgatgccct gctctgtggg aacagcagtg atgctgggca ctgccctaag ggttatgagt     1200

gcatcaagac cgggcggaac cccaactatg gctacaccag ctatgacacc ttcagctggg     1260

ccttcttggc tctcttccgc ctcatgacac aggactattg ggagaacctc ttccagctga     1320

cccttcgagc agctggcaag acctacatga tcttcttcgt ggtcatcatc ttcctgggct     1380

ctttctacct catcaatctg atcctggccg tggtggccat ggcatatgcc gagcagaatg     1440

aggccaccct ggccgaggat aaggagaaag aggaggagtt tcagcagatg cttgagaagt     1500

tcaaaaagca ccaggaggag ctggagaagg ccaaggccgc ccaagctctg gaaggtgggg     1560

aggcagatgg ggacccagcc catggcaaag actgcaatgg cagcctggac acatcgcaag     1620

gggagaaggg agccccgagg cagagcggca gcggagacag cggcatctcc gacgccatgg     1680

aagaactgga agaggcccac caaaagtgcc caccatggtg gtacaagtgc gcccacaaag     1740

tgctcatatg ggactgctgc gccccgtggc tgaagttcaa gaacatcatc cacctgatcg     1800

tcatggaccc gttcgtggac ctgggcatca ccatctgcat cgtgctcaac accctcttca     1860

tggccatgga acattacccc atgacggagc actttgacaa cgtgctcact gtgggcaacc     1920

tggtcttcac aggcatcttc acagcagaga tggttctgaa gctgattgcc atggacccct     1980

acgagtattt ccagcagggt tggaatatct tcgacagcat catcgtcacc ctcagcctgg     2040

tagagctagg cctggccaac gtacagggac tgtctgtgct acgctccttc cgtctgctgc     2100

gggtcttcaa gctggccaag tcgtggccaa cgctgaacat gctcatcaag atcattggca     2160

attcagtggg ggcgctgggt aacctgacgc tggtgctggc tatcatcgtg ttcatcttcg     2220

ccgtggtggg catgcagctg tttggcaaga gctacaagga gtgcgtgtgc aagattgcct     2280

tggactgcaa cctgccgcgc tggcacatgc atgatttctt ccactccttc ctcatcgtct     2340

tccgcatcct gtgcggggag tggatcgaga ccatgtggga ctgcatggag gtggccggcc     2400

aagccatgtg cctcaccgtc ttcctcatgg tcatggtcat cggcaatctt gtggtcctga     2460

acctgttcct ggctctgctg ctgagctcct tcagcgccga cagtctggca gcctcggatg     2520

aggatggcga gatgaacaac ctgcagattg ccatcgggcg catcaagttg ggcatcggct     2580

ttgccaaggc cttcctcctg gggctgctgc atggcaagat cctgagcccc aaggacatca     2640

tgctcagcct cggggaggct gacggggccg gggaggctgg agaggcgggg gagactgccc     2700

ccgaggatga gaagaaggag ccgcccgagg aggacctgaa gaaggacaat cacatcctga     2760

accacatggg cctggctgac ggccccccat ccagcctcga gctggaccac cttaacttca     2820

tcaacaaccc ctacctgacc atacaggtgc ccatcgcctc cgaggagtcc gacctggaga     2880

tgcccaccga ggaggaaacc gacactttct cagagcctga ggatagcaag aagccgccgc     2940

agcctctcta tgatgggaac tcgtccgtct gcagcacagc tgactacaag ccccccgagg     3000

aggaccctga ggagcaggca gaggagaacc ccgaggggga gcagcctgag gagtgcttca     3060

ctgaggcctg cgtgcagcgc tggccctgcc tctacgtgga catctcccag ggccgtggga     3120

agaagtggtg gactctgcgc agggcctgct tcaagattgt cgagcacaac tggttcgaga     3180

ccttcattgt cttcatgatc ctgctcagca gtggggctct ggccttcgag gacatctaca     3240

ttgagcagcg gcgagtcatt cgcaccatcc tagaatatgc cgacaaggtc ttcacctaca     3300

tcttcatcat ggagatgctg ctcaaatggg tggcctacgg ctttaaggtg tacttcacca     3360

acgcctggtg ctggctcgac ttcctcatcg tggatgtctc catcatcagc ttggtggcca     3420

actggctggg ctactcggag ctgggaccca tcaaatccct gcggacactg cgggccctgc     3480

gtcccctgag ggcactgtcc cgattcgagg gcatgagggt ggtggtgaac gccctcctag     3540

gcgccatccc ctccatcatg aatgtgctgc ttgtctgcct catcttctgg ctgatcttca     3600

gcatcatggg tgtcaacctg tttgccggca agttctacta ctgcatcaac accaccacct     3660

ctgagaggtt cgacatctcc gaggtcaaca acaagtctga gtgcgagagc ctcatgcaca     3720

caggccaggt ccgctggctc aatgtcaagg tcaactacga caacgtgggt ctgggctacc     3780

tctccctcct gcaggtggcc accttcaagg gttggatgga catcatgtat gcagccgtgg     3840

actcccggga gaaggaggag cagccgcagt acgaggtgaa cctctacatg tacctctact     3900

ttgtcatctt catcatcttt ggctccttct tcaccctcaa cctcttcatt ggcgtcatca     3960

ttgacaactt caaccagcag aagaagaagt taggggggaa agacatcttt atgacggagg     4020

aacagaagaa atactataac gccatgaaga agcttggctc caagaagcct cagaagccaa     4080

ttccccggcc ccagaacaag atccagggca tggtgtatga cctcgtgacg aagcaggcct     4140

tcgacatcac catcatgatc ctcatctgcc tcaacatggt caccatgatg gtggagacag     4200

acgaccagag ccagctcaag gtggacatcc tgtacaacat caacatgatc ttcatcatca     4260

tcttcacagg ggagtgcgtg ctcaagatgc tcgccctgcg ccagtactac ttcaccgttg     4320

gctggaacat ctttgacttc gtggtcgtca tcctgtccat tgtgggcctt gccctctctg     4380

acctgatcca gaagtacttc gtgtcaccca cgctgttccg tgtgatccgc ctggcgcgga     4440

ttgggcgtgt cctgcggctg atccgcgggg ccaagggcat ccggacgctg ctgttcgccc     4500

tcatgatgtc gctgcctgcc ctcttcaaca tcggcctcct cctcttcctg gtcatgttca     4560

tctactccat cttcggcatg tccaactttg cctacgtcaa gaaggagtcg ggcatcgatg     4620

atatgttcaa cttcgagacc ttcggcaaca gcatcatctg cctgttcgag atcaccacgt     4680

cggccggctg ggacgggctc ctcaacccca tcctcaacag cgggccccca gactgtgacc     4740

ccaacctgga gaacccgggc accagtgtca agggtgactg cggcaacccc tccatcggca     4800

tctgcttctt ctgcagctat atcatcatct ccttcctcat cgtggtcaac atgtacatcg     4860

ccatcatcct ggagaacttc aatgtggcca cagaggagag cagcgagccc cttggtgaag     4920

atgactttga gatgttctac gagacatggg agaagttcga ccccgacgcc acccagttca     4980

tcgcctacag ccgcctctca gacttcgtgg acaccctgca ggaaccgctg aggattgcca     5040

agcccaacaa gatcaagctc atcacactgg acttgcccat ggtgccaggg gacaagatcc     5100

actgcctgga catcctcttt gccctgacca aagaggtcct gggtgactct ggggaaatgg     5160

acgccctcaa gcagaccatg gaggagaagt tcatggcagc caacccctcc aaggtgtcct     5220

acgagcccat caccaccacc ctcaagagga agcacgagga ggtgtgcgcc atcaagatcc     5280

agagggccta ccgccggcac ctgctacagc gctccatgaa gcaggcatcc tacatgtacc     5340

gccacagcca cgacggcagc ggggatgacg cccctgagaa ggaggggctg cttgccaaca     5400

ccatgagcaa gatgtatggc cacgagaatg ggaacagcag ctcgccaagc ccggaggaga     5460

agggcgaggc aggggacgcc ggacccacta tggggctgat gcccatcagc ccctcagaca     5520

ctgcctggcc tcccgcccct cccccagggc agactgtgcg cccaggtgtc aaggagtctc     5580

ttgtctagca ggcagcatcg gggtggcccc actgagtctc ggcatagtcc ccagagctcc     5640

cccgtggtgc ctgcacacag agtgagggag gagggctttg aatctgggac tgtgcctggc     5700

tccctgatgg gggacaggat ttggccacac tggggctgac acccaggccc gagcgcctgc     5760

gttcccagac catgggaaat gggaattgcg ctcaggggct ccatgctggg tctgaggccc     5820

ctgcctccaa gatttaacct gcaagttgct ctgacctcct ctgggccctg tcgcccctcc     5880

ttttggcctg ggggaggtca gaacattcga atctctgccc ctcacttgag gaggagctgg     5940

cctgcggtgg agggatcagt tgccccccat caccagagtc ttaagggtca ctggcctctc     6000

cccaggaagt gggctcagac ccccctcagc cccagcccag acaaagatgt cttaacctca     6060

gggagtgcag acacctaacc ccagggcact gccagcccac cccctttgac tctggggtgc     6120

agcttcaccc accaggccag ctcaggaatt ccctggaaaa gggaaatgtg actggttcag     6180

aaatagctcc tcaaagcctc aaaacctgat tggccactgg atcctgctgc tttgggctgg     6240

gatggtgact cctgaaacct cttcctaggc cacgtccagg tccgtagctc ccctggctgg     6300

ctcctagggg aagagcagaa ggaaggatgc cacttgggaa tgaattgtcc ttttctagga     6360

agcacggggg agtgagacag gctgggtcct gccagctgga tcgctgcaca tggcctgagc     6420

atccagacct gagcgggagt cagggacctg ctgctcagta agaagattct cgccccttcc     6480

ctctctccct gcctcactcc tccgtgagca ccaccagggc tccaggagcc tcatccagcc     6540

tcagagatct cccttctcat ctccccacgc cccgtctctt tctcaccttt cccacctctc     6600

tccccaaagt gatcctaaga atgtacagtt gagctcaggt tagatatttc gaccctgggg     6660

cgtgcagcag ggaaggccca actggttcag gctcaacctt ccaacttcct gtggcctgaa     6720

gaagcacttc tgctgcatcg ctgttctggg catggcaggg ccaggcctct gctggctcag     6780

gaggaggggt gagagacctg ctcaggcgtc gctggattta ttcacttgtg tgtgtacctg     6840

tggctgtgtg tctgcttgta tgcttttata ggcctgtgtg tatagctgtg tgtgtgttca     6900

agtgcgtgac tgtatgtgtg tgtgtgaacc actgtgtgaa ccactgtgta ctggagcctg     6960

cattatgcac gtgtctgggt atctttgtat atatgtgtat atatgtgtgc cctggactgt     7020

ttcaaggtcc atggagtacg gctggtgtgt catactgtgc aggcctgtcc ctgggagtgt     7080

tcccgtgcct gggagagtgg acctgtgctg tgagtgtgtg gatgcgtgtg aacgcatgtg     7140

gtaaggtgtg tactcagggc attctgttgg cctaagtgcc tcttcttttt cttcttgttt     7200

ctcatgaaaa gtttgattaa aattcaggaa gcagcaaaac cttcaaaaca agacatgtat     7260

gtgtgcttga gtgtgtgaac acgtgtgtgt gtgtgcacat ctacatgcca tgcctatggg     7320

ccagagttgt ctttattgtc caccatgctc tctcacctgc ttcccagtcc tgcctgaaca     7380

gccctctctc tcactcccct ctcctcccct tcctgtttct cgttgtcaca cccatggcct     7440

cagccctgct ccctgcctcc tgcctatgtc tcctctatgg aaggaggcct ccactccttc     7500

catctcttcc ttcagaagtt tcgtctaatg ggggcagtct ccccttcctg gcacattgcc     7560

cctctgcctt gccctcctgg gccctgggct ggcacagccc ctggagcctc agaaatctgt     7620

ttgattggat attctcctcg gactgtgtgc aggttgcaga ggaagagtag atgagccggg     7680

tccggcctct ccctgcctgt ggcccctccc ctgcagacgg atgcccattc ctgcctggtc     7740

cagtggggaa caggtcccac gccaggccag caggcgggct cctttgtaca gttcttacaa     7800

taaaccctcc ttggtgcctc tgg                                             7823


<210>  5
<211>  863
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(863)
<223>  Mus musculus amino acid sequence for hyperpolarization-activated 
       cation channel HAC1

<400>  5

Met Asp Ala Arg Gly Gly Gly Gly Arg Pro Gly Asp Ser Pro Gly Thr 
1               5                   10                  15      


Thr Pro Ala Pro Gly Pro Pro Pro Pro Pro Pro Pro Pro Ala Pro Pro 
            20                  25                  30          


Gln Pro Gln Pro Pro Pro Ala Pro Pro Pro Asn Pro Thr Thr Pro Ser 
        35                  40                  45              


His Pro Glu Ser Ala Asp Glu Pro Gly Pro Arg Ala Arg Leu Cys Ser 
    50                  55                  60                  


Arg Asp Ser Ala Cys Thr Pro Gly Ala Ala Lys Gly Gly Ala Asn Gly 
65                  70                  75                  80  


Glu Cys Gly Arg Gly Glu Pro Gln Cys Ser Pro Glu Gly Pro Ala Arg 
                85                  90                  95      


Gly Pro Lys Val Ser Phe Ser Cys Arg Gly Ala Ala Ser Gly Pro Ser 
            100                 105                 110         


Ala Ala Glu Glu Ala Gly Ser Glu Glu Ala Gly Pro Ala Gly Glu Pro 
        115                 120                 125             


Arg Gly Ser Gln Ala Ser Phe Leu Gln Arg Gln Phe Gly Ala Leu Leu 
    130                 135                 140                 


Gln Pro Gly Val Asn Lys Phe Ser Leu Arg Met Phe Gly Ser Gln Lys 
145                 150                 155                 160 


Ala Val Glu Arg Glu Gln Glu Arg Val Lys Ser Ala Gly Ala Trp Ile 
                165                 170                 175     


Ile His Pro Tyr Ser Asp Phe Arg Phe Tyr Trp Asp Phe Thr Met Leu 
            180                 185                 190         


Leu Phe Met Val Gly Asn Leu Ile Ile Ile Pro Val Gly Ile Thr Phe 
        195                 200                 205             


Phe Lys Asp Glu Thr Thr Ala Pro Trp Ile Val Phe Asn Val Val Ser 
    210                 215                 220                 


Asp Thr Phe Phe Leu Met Asp Leu Val Leu Asn Phe Arg Thr Gly Ile 
225                 230                 235                 240 


Val Ile Glu Asp Asn Thr Glu Ile Ile Leu Asp Pro Glu Lys Ile Lys 
                245                 250                 255     


Lys Lys Tyr Leu Arg Thr Trp Phe Val Val Asp Phe Val Ser Ser Ile 
            260                 265                 270         


Pro Val Asp Tyr Ile Phe Leu Ile Val Glu Lys Gly Ile Asp Ser Glu 
        275                 280                 285             


Val Tyr Lys Thr Ala Arg Ala Leu Arg Ile Val Arg Phe Thr Lys Ile 
    290                 295                 300                 


Leu Ser Leu Leu Arg Leu Leu Arg Leu Ser Arg Leu Ile Arg Tyr Ile 
305                 310                 315                 320 


His Gln Trp Glu Glu Ile Phe His Met Thr Tyr Asp Leu Ala Ser Ala 
                325                 330                 335     


Val Met Arg Ile Cys Asn Leu Ile Ser Met Met Leu Leu Leu Cys His 
            340                 345                 350         


Trp Asp Gly Cys Leu Gln Phe Leu Val Pro Met Leu Gln Asp Phe Pro 
        355                 360                 365             


Ser Asp Cys Trp Val Ser Ile Asn Asn Met Val Asn His Ser Trp Ser 
    370                 375                 380                 


Glu Leu Tyr Ser Phe Ala Leu Phe Lys Ala Met Ser His Met Leu Cys 
385                 390                 395                 400 


Ile Gly Tyr Gly Arg Gln Ala Pro Glu Ser Met Thr Asp Ile Trp Leu 
                405                 410                 415     


Thr Met Leu Ser Met Ile Val Gly Ala Thr Cys Tyr Ala Met Phe Ile 
            420                 425                 430         


Gly His Ala Thr Ala Leu Ile Gln Ser Leu Asp Ser Ser Arg Arg Gln 
        435                 440                 445             


Tyr Gln Glu Lys Tyr Lys Gln Val Glu Gln Tyr Met Ser Phe His Lys 
    450                 455                 460                 


Leu Pro Ala Asp Phe Arg Gln Lys Ile His Asp Tyr Tyr Glu His Arg 
465                 470                 475                 480 


Tyr Gln Gly Lys Met Phe Asp Glu Asp Ser Ile Leu Gly Glu Leu Asn 
                485                 490                 495     


Gly Pro Leu Arg Glu Glu Ile Val Asn Phe Asn Cys Arg Lys Leu Val 
            500                 505                 510         


Ala Ser Met Pro Leu Phe Ala Asn Ala Asp Pro Asn Phe Val Thr Ala 
        515                 520                 525             


Met Leu Thr Lys Leu Lys Phe Glu Val Phe Gln Pro Gly Asp Tyr Ile 
    530                 535                 540                 


Ile Arg Glu Gly Thr Ile Gly Lys Lys Met Tyr Phe Ile Gln His Gly 
545                 550                 555                 560 


Val Val Ser Val Leu Thr Lys Gly Asn Lys Glu Met Lys Leu Ser Asp 
                565                 570                 575     


Gly Ser Tyr Phe Gly Glu Ile Cys Leu Leu Thr Arg Gly Arg Arg Thr 
            580                 585                 590         


Ala Ser Val Arg Ala Asp Thr Tyr Cys Arg Leu Tyr Ser Leu Ser Val 
        595                 600                 605             


Asp Asn Phe Asn Glu Val Leu Glu Glu Tyr Pro Met Met Arg Arg Ala 
    610                 615                 620                 


Phe Glu Thr Val Ala Ile Asp Arg Leu Asp Arg Ile Gly Lys Lys Asn 
625                 630                 635                 640 


Ser Ile Leu Leu His Lys Val Gln His Asp Leu Ser Ser Gly Val Phe 
                645                 650                 655     


Asn Asn Gln Glu Asn Ala Ile Ile Gln Glu Ile Val Lys Tyr Asp Arg 
            660                 665                 670         


Glu Met Val Gln Gln Ala Glu Leu Gly Gln Arg Val Gly Leu Phe Pro 
        675                 680                 685             


Pro Pro Pro Pro Pro Gln Val Thr Ser Ala Ile Ala Thr Leu Gln Gln 
    690                 695                 700                 


Ala Val Ala Met Ser Phe Cys Pro Gln Val Ala Arg Pro Leu Val Gly 
705                 710                 715                 720 


Pro Leu Ala Leu Gly Ser Pro Arg Leu Val Arg Arg Ala Pro Pro Gly 
                725                 730                 735     


Pro Leu Pro Pro Ala Ala Ser Pro Gly Pro Pro Ala Ala Ser Pro Pro 
            740                 745                 750         


Ala Ala Pro Ser Ser Pro Arg Ala Pro Arg Thr Ser Pro Tyr Gly Val 
        755                 760                 765             


Pro Gly Ser Pro Ala Thr Arg Val Gly Pro Ala Leu Pro Ala Arg Arg 
    770                 775                 780                 


Leu Ser Arg Ala Ser Arg Pro Leu Ser Ala Ser Gln Pro Ser Leu Pro 
785                 790                 795                 800 


His Gly Val Pro Ala Pro Ser Pro Ala Ala Ser Ala Arg Pro Ala Ser 
                805                 810                 815     


Ser Ser Thr Pro Arg Leu Gly Pro Ala Pro Thr Ala Arg Thr Ala Ala 
            820                 825                 830         


Pro Ser Pro Asp Arg Arg Asp Ser Ala Ser Pro Gly Ala Ala Ser Gly 
        835                 840                 845             


Leu Asp Pro Leu Asp Ser Ala Arg Ser Arg Leu Ser Ser Asn Leu 
    850                 855                 860             


<210>  6
<211>  3102
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(3102)
<223>  Mus musculus nucleic acid sequence encoding mRNA sequence for 
       hyperpolarization-activated cation channel HAC1

<400>  6
ccgctccgct ccgcactgcc cggcgccgcc tcgccatgga tgcgcgcggg ggcggcgggc       60

ggccgggcga tagtccgggc acgacccctg cgccggggcc gccgccaccg ccgccgccgc      120

ccgcgccccc tcagcctcag ccaccacccg cgccaccccc gaaccccacg accccctcgc      180

acccggagtc ggcggacgag cccggcccgc gcgcccggct ctgcagccgc gacagcgcct      240

gcacccctgg cgcggccaag ggcggcgcga atggcgagtg cgggcgcggg gagccgcagt      300

gcagccccga gggccccgcg cgcggcccca aggtttcgtt ctcatgccgc ggggcggcct      360

ccgggccctc ggcggccgag gaggcgggca gcgaggaggc gggcccggcg ggtgagccgc      420

gcggcagcca ggctagcttc ctgcagcgcc aattcggggc gcttctgcag cccggcgtca      480

acaagttctc cctgcggatg ttcggcagcc agaaggccgt ggagcgcgag caggaacgcg      540

tgaagtcggc gggggcctgg atcatccacc cctacagcga cttcaggttc tactgggact      600

tcaccatgct gttgttcatg gtgggaaatc tcattatcat tcccgtgggc atcactttct      660

tcaaggacga gaccaccgcg ccctggatcg tcttcaacgt ggtctcggac actttcttcc      720

tcatggactt ggtgttgaac ttccgcaccg gcattgttat tgaggacaac acggagatca      780

tcctggaccc cgagaagata aagaagaagt acttgcgtac gtggttcgtg gtggacttcg      840

tgtcatccat cccggtggac tacatcttcc tcatagtgga gaagggaatc gactccgagg      900

tctacaagac agcgcgtgct ctgcgcatcg tgcgcttcac caagatcctc agtctgctgc      960

ggctgctgcg gctatcacgg ctcatccgat atatccacca gtgggaagag attttccaca     1020

tgacctacga cctggcaagt gcagtgatgc gcatctgtaa cctgatcagc atgatgctac     1080

tgctctgcca ctgggacggt tgcctgcagt tcctggtgcc catgctgcaa gacttcccca     1140

gcgactgctg ggtgtccatc aacaacatgg tgaaccactc gtggagcgag ctctactcgt     1200

tcgcgctctt caaggccatg agccacatgc tgtgcatcgg ctacgggcgg caggcgcccg     1260

agagcatgac agacatctgg ctgaccatgc tcagcatgat cgtaggcgcc acctgctatg     1320

ccatgttcat tgggcacgcc actgcgctca tccagtccct ggattcgtca cggcgccaat     1380

accaggagaa gtacaagcaa gtagagcaat acatgtcctt ccacaaactg cccgctgact     1440

tccgccagaa gatccacgat tactatgaac accggtacca agggaagatg tttgatgagg     1500

acagcatcct tggggaactc aacgggccac tgcgtgagga gattgtgaac ttcaactgcc     1560

ggaagctggt ggcttccatg ccgctgtttg ccaatgcaga ccccaacttc gtcacagcca     1620

tgctgacaaa gctcaaattt gaggtcttcc agcctggaga ttacatcatc cgagagggga     1680

ccatcgggaa gaagatgtac ttcatccagc atggggtggt gagcgtgctc accaagggca     1740

acaaggagat gaagctgtcg gatggctcct atttcgggga gatctgcttg ctcacgaggg     1800

gccggcgtac ggccagcgtg cgagctgaca cctactgtcg cctctactca ctgagtgtgg     1860

acaatttcaa cgaggtgctg gaggaatacc ccatgatgcg gcgtgccttt gagactgtgg     1920

ctattgaccg gctagatcgc ataggcaaga agaactccat cttgctgcac aaggttcagc     1980

atgatctcag ctcaggtgtg ttcaacaacc aggagaatgc catcatccag gagattgtca     2040

aatatgaccg tgagatggtg cagcaggcag agcttggcca gcgtgtgggg ctcttcccac     2100

caccgccacc accgcaggtc acatcggcca ttgccaccct acagcaggct gtggccatga     2160

gcttctgccc gcaggtggcc cgcccgctcg tggggcccct ggcgctaggc tccccacgcc     2220

tagtgcgccg cgcgccccca gggcctctgc ctcctgcagc ctcgccaggg ccacccgcag     2280

caagcccccc ggctgcaccc tcgagccctc gggcaccgcg gacctcaccc tacggtgtgc     2340

ctggctctcc ggcaacgcgc gtggggcccg cattgcccgc acgtcgcctg agccgcgcct     2400

cgcgcccact gtccgcctcg cagccctcgc tgccccatgg cgtgcccgcg cccagccccg     2460

cggcctctgc gcgcccggcc agcagctcca cgccgcgcct gggacccgca cccaccgccc     2520

ggaccgccgc gcccagtccg gaccgcaggg actcagcctc gccgggcgct gccagtggcc     2580

tcgacccact ggactctgcg cgctcgcgcc tctcttccaa cttgtgaccc ttgagcgccg     2640

ccccgcgggc cgggcggggc cgtcatccac accaaagcca tgcctcgcgc cgcccgcccg     2700

tgcccgtgca gaagccatag agggacgtag gtagcttagg aggcgggcgg ccctgcgccc     2760

ggctgtcccc ccatcgccct gcgcccaccc ccatcgcccc tgccccagcg gcggccgcac     2820

gggagaggga ggggtgcgat cacctcggtg cctcagcccc aacctgggac agggacaggg     2880

cggccctggc cgaggacctg gctgtgcccc gcatgtgcgg tggcctccga ggaagaatat     2940

ggatcaagtg caatacacgg ccaagccggc gtgggggtga ggctgggtcc ccggccgtcg     3000

ccatgaatgt actgacgagc cgaggcagca gtggccccca cgccccatta acccacaacc     3060

ccattccgcg caataaacga cagcattggc aaaaaaaaaa aa                        3102


<210>  7
<211>  889
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(889)
<223>  amino acid sequence for  the protein Homo sapiens 
       hyperpolarization-activated, cyclic nucleotide-gated channel 2 
       (HCN2)

<400>  7

Met Asp Ala Arg Gly Gly Gly Gly Arg Pro Gly Glu Ser Pro Gly Ala 
1               5                   10                  15      


Ser Pro Thr Thr Gly Pro Pro Pro Pro Pro Pro Pro Arg Pro Pro Lys 
            20                  25                  30          


Gln Gln Pro Pro Pro Pro Pro Pro Pro Ala Pro Pro Pro Gly Pro Gly 
        35                  40                  45              


Pro Ala Pro Pro Gln His Pro Pro Arg Ala Glu Ala Leu Pro Pro Glu 
    50                  55                  60                  


Ala Ala Asp Glu Gly Gly Pro Arg Gly Arg Leu Arg Ser Arg Asp Ser 
65                  70                  75                  80  


Ser Cys Gly Arg Pro Gly Thr Pro Gly Ala Ala Ser Thr Ala Lys Gly 
                85                  90                  95      


Ser Pro Asn Gly Glu Cys Gly Arg Gly Glu Pro Gln Cys Ser Pro Ala 
            100                 105                 110         


Gly Pro Glu Gly Pro Ala Arg Gly Pro Lys Val Ser Phe Ser Cys Arg 
        115                 120                 125             


Gly Ala Ala Ser Gly Pro Ala Pro Gly Pro Gly Pro Ala Glu Glu Ala 
    130                 135                 140                 


Gly Ser Glu Glu Ala Gly Pro Ala Gly Glu Pro Arg Gly Ser Gln Ala 
145                 150                 155                 160 


Ser Phe Met Gln Arg Gln Phe Gly Ala Leu Leu Gln Pro Gly Val Asn 
                165                 170                 175     


Lys Phe Ser Leu Arg Met Phe Gly Ser Gln Lys Ala Val Glu Arg Glu 
            180                 185                 190         


Gln Glu Arg Val Lys Ser Ala Gly Ala Trp Ile Ile His Pro Tyr Ser 
        195                 200                 205             


Asp Phe Arg Phe Tyr Trp Asp Phe Thr Met Leu Leu Phe Met Val Gly 
    210                 215                 220                 


Asn Leu Ile Ile Ile Pro Val Gly Ile Thr Phe Phe Lys Asp Glu Thr 
225                 230                 235                 240 


Thr Ala Pro Trp Ile Val Phe Asn Val Val Ser Asp Thr Phe Phe Leu 
                245                 250                 255     


Met Asp Leu Val Leu Asn Phe Arg Thr Gly Ile Val Ile Glu Asp Asn 
            260                 265                 270         


Thr Glu Ile Ile Leu Asp Pro Glu Lys Ile Lys Lys Lys Tyr Leu Arg 
        275                 280                 285             


Thr Trp Phe Val Val Asp Phe Val Ser Ser Ile Pro Val Asp Tyr Ile 
    290                 295                 300                 


Phe Leu Ile Val Glu Lys Gly Ile Asp Ser Glu Val Tyr Lys Thr Ala 
305                 310                 315                 320 


Arg Ala Leu Arg Ile Val Arg Phe Thr Lys Ile Leu Ser Leu Leu Arg 
                325                 330                 335     


Leu Leu Arg Leu Ser Arg Leu Ile Arg Tyr Ile His Gln Trp Glu Glu 
            340                 345                 350         


Ile Phe His Met Thr Tyr Asp Leu Ala Ser Ala Val Met Arg Ile Cys 
        355                 360                 365             


Asn Leu Ile Ser Met Met Leu Leu Leu Cys His Trp Asp Gly Cys Leu 
    370                 375                 380                 


Gln Phe Leu Val Pro Met Leu Gln Asp Phe Pro Arg Asn Cys Trp Val 
385                 390                 395                 400 


Ser Ile Asn Gly Met Val Asn His Ser Trp Ser Glu Leu Tyr Ser Phe 
                405                 410                 415     


Ala Leu Phe Lys Ala Met Ser His Met Leu Cys Ile Gly Tyr Gly Arg 
            420                 425                 430         


Gln Ala Pro Glu Ser Met Thr Asp Ile Trp Leu Thr Met Leu Ser Met 
        435                 440                 445             


Ile Val Gly Ala Thr Cys Tyr Ala Met Phe Ile Gly His Ala Thr Ala 
    450                 455                 460                 


Leu Ile Gln Ser Leu Asp Ser Ser Arg Arg Gln Tyr Gln Glu Lys Tyr 
465                 470                 475                 480 


Lys Gln Val Glu Gln Tyr Met Ser Phe His Lys Leu Pro Ala Asp Phe 
                485                 490                 495     


Arg Gln Lys Ile His Asp Tyr Tyr Glu His Arg Tyr Gln Gly Lys Met 
            500                 505                 510         


Phe Asp Glu Asp Ser Ile Leu Gly Glu Leu Asn Gly Pro Leu Arg Glu 
        515                 520                 525             


Glu Ile Val Asn Phe Asn Cys Arg Lys Leu Val Ala Ser Met Pro Leu 
    530                 535                 540                 


Phe Ala Asn Ala Asp Pro Asn Phe Val Thr Ala Met Leu Thr Lys Leu 
545                 550                 555                 560 


Lys Phe Glu Val Phe Gln Pro Gly Asp Tyr Ile Ile Arg Glu Gly Thr 
                565                 570                 575     


Ile Gly Lys Lys Met Tyr Phe Ile Gln His Gly Val Val Ser Val Leu 
            580                 585                 590         


Thr Lys Gly Asn Lys Glu Met Lys Leu Ser Asp Gly Ser Tyr Phe Gly 
        595                 600                 605             


Glu Ile Cys Leu Leu Thr Arg Gly Arg Arg Thr Ala Ser Val Arg Ala 
    610                 615                 620                 


Asp Thr Tyr Cys Arg Leu Tyr Ser Leu Ser Val Asp Asn Phe Asn Glu 
625                 630                 635                 640 


Val Leu Glu Glu Tyr Pro Met Met Arg Arg Ala Phe Glu Thr Val Ala 
                645                 650                 655     


Ile Asp Arg Leu Asp Arg Ile Gly Lys Lys Asn Ser Ile Leu Leu His 
            660                 665                 670         


Lys Val Gln His Asp Leu Asn Ser Gly Val Phe Asn Asn Gln Glu Asn 
        675                 680                 685             


Ala Ile Ile Gln Glu Ile Val Lys Tyr Asp Arg Glu Met Val Gln Gln 
    690                 695                 700                 


Ala Glu Leu Gly Gln Arg Val Gly Leu Phe Pro Pro Pro Pro Pro Pro 
705                 710                 715                 720 


Pro Gln Val Thr Ser Ala Ile Ala Thr Leu Gln Gln Ala Ala Ala Met 
                725                 730                 735     


Ser Phe Cys Pro Gln Val Ala Arg Pro Leu Val Gly Pro Leu Ala Leu 
            740                 745                 750         


Gly Ser Pro Arg Leu Val Arg Arg Pro Pro Pro Gly Pro Ala Pro Ala 
        755                 760                 765             


Ala Ala Ser Pro Gly Pro Pro Pro Pro Ala Ser Pro Pro Gly Ala Pro 
    770                 775                 780                 


Ala Ser Pro Arg Ala Pro Arg Thr Ser Pro Tyr Gly Gly Leu Pro Ala 
785                 790                 795                 800 


Ala Pro Leu Ala Gly Pro Ala Leu Pro Ala Arg Arg Leu Ser Arg Ala 
                805                 810                 815     


Ser Arg Pro Leu Ser Ala Ser Gln Pro Ser Leu Pro His Gly Ala Pro 
            820                 825                 830         


Gly Pro Ala Ala Ser Thr Arg Pro Ala Ser Ser Ser Thr Pro Arg Leu 
        835                 840                 845             


Gly Pro Thr Pro Ala Ala Arg Ala Ala Ala Pro Ser Pro Asp Arg Arg 
    850                 855                 860                 


Asp Ser Ala Ser Pro Gly Ala Ala Gly Gly Leu Asp Pro Gln Asp Ser 
865                 870                 875                 880 


Ala Arg Ser Arg Leu Ser Ser Asn Leu 
                885                 


<210>  8
<211>  3372
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(3372)
<223>  nucleic acid sequence encoding GenBank: AF065164.2

<400>  8
cggctccgct ccgcactgcc cggcgccgcc tcgccatgga cgcgcgcggg ggcggcgggc       60

ggcccgggga gagcccgggc gcgagcccca cgaccgggcc gccgccgccg ccgcccccgc      120

gcccccccaa acagcagccg ccgccgccgc cgccgcccgc gccccccccg ggccccgggc      180

ccgcgccccc ccagcacccg ccccgggccg aggcgttgcc cccggaggcg gcggatgagg      240

gcggcccgcg gggccggctc cgcagccgcg acagctcgtg cggccgcccc ggcaccccgg      300

gcgcggcgag cacggccaag ggcagcccga acggcgagtg cgggcgcggc gagccgcagt      360

gcagccccgc ggggcccgag ggcccggcgc gggggcccaa ggtgtcgttc tcgtgccgcg      420

gggcggcctc ggggcccgcg ccggggccgg ggccggcgga ggaggcgggc agcgaggagg      480

cgggcccggc gggggagccg cgcggcagcc aggccagctt catgcagcgc cagttcggcg      540

cgctcctgca gccgggcgtc aacaagttct cgctgcggat gttcggcagc cagaaggccg      600

tggagcgcga gcaggagcgc gtcaagtcgg cgggggcctg gatcatccac ccgtacagcg      660

acttcaggtt ctactgggac ttcaccatgc tgctgttcat ggtgggaaac ctcatcatca      720

tcccagtggg catcaccttc ttcaaggatg agaccactgc cccgtggatc gtgttcaacg      780

tggtctcgga caccttcttc ctcatggacc tggtgttgaa cttccgcacc ggcattgtga      840

tcgaggacaa cacggagatc atcctggacc ccgagaagat caagaagaag tatctgcgca      900

cgtggttcgt ggtggacttc gtgtcctcca tccccgtgga ctacatcttc cttatcgtgg      960

agaagggcat tgactccgag gtctacaaga cggcacgcgc cctgcgcatc gtgcgcttca     1020

ccaagatcct cagcctcctg cggctgctgc gcctctcacg cctgatccgc tacatccatc     1080

agtgggagga gatcttccac atgacctatg acctggccag cgcggtgatg aggatctgca     1140

atctcatcag catgatgctg ctgctctgcc actgggacgg ctgcctgcag ttcctggtgc     1200

ctatgctgca ggacttcccg cgcaactgct gggtgtccat caatggcatg gtgaaccact     1260

cgtggagtga actgtactcc ttcgcactct tcaaggccat gagccacatg ctgtgcatcg     1320

ggtacggccg gcaggcgccc gagagcatga cggacatctg gctgaccatg ctcagcatga     1380

ttgtgggtgc cacctgctac gccatgttca tcggccacgc cactgccctc atccagtcgc     1440

tggactcctc gcggcgccag taccaggaga agtacaagca ggtggagcag tacatgtcct     1500

tccacaagct gccagctgac ttccgccaga agatccacga ctactatgag caccgttacc     1560

agggcaagat gtttgacgag gacagcatcc tgggcgagct caacgggccc ctgcgggagg     1620

agatcgtcaa cttcaactgc cggaagctgg tggcctccat gccgctgttc gccaacgccg     1680

accccaactt cgtcacggcc atgctgacca agctcaagtt cgaggtcttc cagccgggtg     1740

actacatcat ccgcgaaggc accatcggga agaagatgta cttcatccag cacggcgtgg     1800

tcagcgtgct cactaagggc aacaaggaga tgaagctgtc cgatggctcc tacttcgggg     1860

agatctgcct gctcacccgg ggccgccgca cggcgagcgt gcgggctgac acctactgcc     1920

gcctctattc gctgagcgtg gacaacttca acgaggtgct ggaggagtac cccatgatgc     1980

ggcgcgcctt cgagacggtg gccatcgacc gcctggaccg catcggcaag aagaattcca     2040

tcctcctgca caaggtgcag catgacctca actcgggcgt attcaacaac caggagaacg     2100

ccatcatcca ggagatcgtc aagtacgacc gcgagatggt gcagcaggcc gagctgggtc     2160

agcgcgtggg cctcttcccg ccgccgccgc cgccgccgca ggtcacctcg gccatcgcca     2220

cgctgcagca ggcggcggcc atgagcttct gcccgcaggt ggcgcggccg ctcgtggggc     2280

cgctggcgct cggctcgccg cgcctcgtgc gccgcccgcc cccggggccc gcacctgccg     2340

ccgcctcacc cgggcccccg ccccccgcca gccccccggg cgcgcccgcc agcccccggg     2400

caccgcggac ctcgccctac ggcggcctgc ccgccgcccc ccttgctggg cccgccctgc     2460

ccgcgcgccg cctgagccgc gcgtcgcgcc cactgtccgc ctcgcagccc tcgctgcctc     2520

acggcgcccc cggccccgcg gcctccacac gcccggccag cagctccaca ccgcgcttgg     2580

ggcccacgcc cgctgcccgg gccgccgcgc ccagcccgga ccgcagggac tcggcctcac     2640

ccggcgccgc cggcggcctg gacccccagg actccgcgcg ctcgcgcctc tcgtccaact     2700

tgtgaccctc gccgaccgcc ccgcgggccc aggcgggccg ggggcggggc cgtcatccag     2760

accaaagcca tgccattgcg ctgccccggc cgccagtccg cccagaagcc atagacgaga     2820

cgtaggtagc cgtagttgga cggacgggca gggccggcgg ggcagccccc tccgcgcccc     2880

cggccgtccc ccctcatcgc cccgcgccca cccccatcgc ccctgccccc ggcggcggcc     2940

tcgcgtgcga gggggctccc ttcacctcgg tgcctcagtt cccccagctg taagacaggg     3000

acggggcggc ccagtggctg agaggagccg gctgtggagc cccgcccgcc ccccaccctc     3060

taggtggccc ccgtccgagg aggatcgttt tctaagtgca atacttggcc cgccggcttc     3120

ccgctgcccc catcgcgctc acgcaataac cggcccggcc cccgtccgcg cgcgtccccc     3180

ggtgacctcg gggagcagca ccccgcctcc ctccagcact ggcaccgaga ggcaggcctg     3240

gctgcgcagg gcgcgggggg gaggctgggg tcccgccgcc gtgatgaatg tactgacgag     3300

ccgaggcagc agtgccccca ccgtggcccc ccacgcccca ttaaccccca cacccccatt     3360

ccgcgcaata aa                                                         3372


<210>  9
<211>  123
<212>  PRT
<213>  Rattus norvegicus


<220>
<221>  misc_feature
<222>  (1)..(123)
<223>  amino acid sequence for Rattus norvegicus minK-related peptide 1 
       mRNA, complete cds

<400>  9

Met Thr Thr Leu Ala Asn Leu Thr Gln Thr Leu Glu Asp Ala Phe Lys 
1               5                   10                  15      


Lys Val Phe Ile Thr Tyr Met Asp Ser Trp Arg Arg Asn Thr Thr Ala 
            20                  25                  30          


Glu Gln Gln Ala Leu Gln Ala Arg Val Asp Ala Glu Asn Phe Tyr Tyr 
        35                  40                  45              


Val Ile Leu Tyr Leu Met Val Met Ile Gly Met Phe Ala Phe Ile Val 
    50                  55                  60                  


Val Ala Ile Leu Val Ser Thr Val Lys Ser Lys Arg Arg Glu His Ser 
65                  70                  75                  80  


Gln Asp Pro Tyr His Gln Tyr Ile Val Glu Asp Trp Gln Gln Lys Tyr 
                85                  90                  95      


Arg Ser Gln Ile Leu His Leu Glu Asp Ser Lys Ala Thr Ile His Glu 
            100                 105                 110         


Asn Leu Gly Ala Thr Gly Phe Thr Val Ser Pro 
        115                 120             


<210>  10
<211>  468
<212>  DNA
<213>  Rattus norvegicus


<220>
<221>  misc_feature
<222>  (1)..(468)
<223>  nucleic acid sequence encoding the mRNA GenBank: AF071003.1

<400>  10
cctgtgagga atctctcatc ctcaaggggg aaacatgacc actttagcca acttgacgca       60

gaccctggag gatgccttca aaaaggtttt cattacttat atggacagct ggaggaggaa      120

cacaacagcc gaacaacagg cgctccaggc cagagtggat gccgagaact tctactacgt      180

catcctgtac ctcatggtga tgatcggcat gttcgccttc atcgtggtgg ccatcctggt      240

gagcacggtg aagtcgaagc ggcgggagca ctcccaggac ccgtaccacc agtacatcgt      300

ggaggattgg cagcagaagt ataggagtca gatcttgcat ctggaagact ccaaggccac      360

catccatgag aacctggggg cgacggggtt cacagtgtca ccctgataaa gaacgagagt      420

ccatctgccc aggaaggggt gcttctgccg ccttgaagcc ccacttgc                   468


<210>  11
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(123)
<223>  amino acid sequence for Homo sapiens potassium voltage-gated 
       channel, Isk-related family, member 2 (KCNE2)

<400>  11

Met Ser Thr Leu Ser Asn Phe Thr Gln Thr Leu Glu Asp Val Phe Arg 
1               5                   10                  15      


Arg Ile Phe Ile Thr Tyr Met Asp Asn Trp Arg Gln Asn Thr Thr Ala 
            20                  25                  30          


Glu Gln Glu Ala Leu Gln Ala Lys Val Asp Ala Glu Asn Phe Tyr Tyr 
        35                  40                  45              


Val Ile Leu Tyr Leu Met Val Met Ile Gly Met Phe Ser Phe Ile Ile 
    50                  55                  60                  


Val Ala Ile Leu Val Ser Thr Val Lys Ser Lys Arg Arg Glu His Ser 
65                  70                  75                  80  


Asn Asp Pro Tyr His Gln Tyr Ile Val Glu Asp Trp Gln Glu Lys Tyr 
                85                  90                  95      


Lys Ser Gln Ile Leu Asn Leu Glu Glu Ser Lys Ala Thr Ile His Glu 
            100                 105                 110         


Asn Ile Gly Ala Ala Gly Phe Lys Met Ser Pro 
        115                 120             


<210>  12
<211>  809
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(809)
<223>  nucleic acid sequence encoding NCBI Reference Sequence: 
       NM_172201.1

<400>  12
gtaaggtgaa ggtgcccagc aggctgaggc ttgtgtgcaa cccagaagag agctcgctaa       60

cgccagcaag aaggttcaga acagcctggc tttggaaagg aatttcatcc tgcccacaca      120

ctgcatagca ggagggaagc atgtctactt tatccaattt cacacagacg ctggaagacg      180

tcttccgaag gatttttatt acttatatgg acaattggcg ccagaacaca acagctgagc      240

aagaggccct ccaagccaaa gttgatgctg agaacttcta ctatgtcatc ctgtacctca      300

tggtgatgat tggaatgttc tctttcatca tcgtggccat cctggtgagc actgtgaaat      360

ccaagagacg ggaacactcc aatgacccct accaccagta cattgtagag gactggcagg      420

aaaagtacaa gagccaaatc ttgaatctag aagaatcgaa ggccaccatc catgagaaca      480

ttggtgcggc tgggttcaaa atgtccccct gataagggag aaaggcacca agctaacatc      540

tgacgtccag acatgaagag atgccagtgc cacgaggcaa atccaaattg tctttgctta      600

gaagaaagtg agttccttgc tctctgttga gaattttcat ggagattatg tggttggcca      660

ataaagatag atgacatttc aatctcagtg atttatgctt gcttgttgga gcaatatttt      720

gtgctgaaga cctcttttac tttccgggca agtgaatgtc attttaatca atatcaatga      780

tgaaaataaa gccaaatttg aagaaaaaa                                        809


<210>  13
<211>  1840
<212>  PRT
<213>  Rattus norvegicus


<220>
<221>  misc_feature
<222>  (1)..(1840)
<223>  amino acid sequence for Rattus norvegicus sodium channel, 
       voltage-gated, type IV, alpha subunit (Scn4a)

<400>  13

Met Ala Ser Ser Ser Leu Pro Asn Leu Val Pro Pro Gly Pro His Cys 
1               5                   10                  15      


Leu Arg Pro Phe Thr Pro Glu Ser Leu Ala Ala Ile Glu Gln Arg Ala 
            20                  25                  30          


Val Glu Glu Glu Ala Arg Leu Gln Arg Asn Lys Gln Met Glu Ile Glu 
        35                  40                  45              


Glu Pro Glu Arg Lys Pro Arg Ser Asp Leu Glu Ala Gly Lys Asn Leu 
    50                  55                  60                  


Pro Leu Ile Tyr Gly Asp Pro Pro Pro Glu Val Ile Gly Ile Pro Leu 
65                  70                  75                  80  


Glu Asp Leu Asp Pro Tyr Tyr Ser Asp Lys Lys Thr Phe Ile Val Leu 
                85                  90                  95      


Asn Lys Gly Lys Ala Ile Phe Arg Phe Ser Ala Thr Pro Ala Leu Tyr 
            100                 105                 110         


Leu Leu Ser Pro Phe Ser Ile Val Arg Arg Val Ala Ile Lys Val Leu 
        115                 120                 125             


Ile His Ala Leu Phe Ser Met Phe Ile Met Ile Thr Ile Leu Thr Asn 
    130                 135                 140                 


Cys Val Phe Met Thr Met Ser Asn Pro Pro Ser Trp Ser Lys His Val 
145                 150                 155                 160 


Glu Tyr Thr Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Met 
                165                 170                 175     


Leu Ala Arg Gly Phe Cys Ile Asp Asp Phe Thr Phe Leu Arg Asp Pro 
            180                 185                 190         


Trp Asn Trp Leu Asp Phe Ser Val Ile Thr Met Ala Tyr Val Thr Glu 
        195                 200                 205             


Phe Val Asp Leu Gly Asn Ile Ser Ala Leu Arg Thr Phe Arg Val Leu 
    210                 215                 220                 


Arg Ala Leu Lys Thr Ile Thr Val Ile Pro Gly Leu Lys Thr Ile Val 
225                 230                 235                 240 


Gly Ala Leu Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu 
                245                 250                 255     


Thr Val Phe Cys Leu Ser Val Phe Ala Leu Val Gly Leu Gln Leu Phe 
            260                 265                 270         


Met Gly Asn Leu Arg Gln Lys Cys Val Arg Trp Pro Pro Pro Met Asn 
        275                 280                 285             


Asp Thr Asn Thr Thr Trp Tyr Gly Asn Asp Thr Trp Tyr Ser Asn Asp 
    290                 295                 300                 


Thr Trp Tyr Gly Asn Asp Thr Trp Tyr Ile Asn Asp Thr Trp Asn Ser 
305                 310                 315                 320 


Gln Glu Ser Trp Ala Gly Asn Ser Thr Phe Asp Trp Glu Ala Tyr Ile 
                325                 330                 335     


Asn Asp Glu Gly Asn Phe Tyr Phe Leu Glu Gly Ser Asn Asp Ala Leu 
            340                 345                 350         


Leu Cys Gly Asn Ser Ser Asp Ala Gly His Cys Pro Glu Gly Tyr Glu 
        355                 360                 365             


Cys Ile Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Tyr Asp 
    370                 375                 380                 


Thr Phe Ser Trp Ala Phe Leu Ala Leu Phe Arg Leu Met Thr Gln Asp 
385                 390                 395                 400 


Tyr Trp Glu Asn Leu Phe Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr 
                405                 410                 415     


Tyr Met Ile Phe Phe Val Val Ile Ile Phe Leu Gly Ser Phe Tyr Leu 
            420                 425                 430         


Ile Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr Ala Glu Gln Asn 
        435                 440                 445             


Glu Ala Thr Leu Ala Glu Asp Gln Glu Lys Glu Glu Glu Phe Gln Gln 
    450                 455                 460                 


Met Leu Glu Lys Tyr Lys Lys His Gln Glu Glu Leu Glu Lys Ala Lys 
465                 470                 475                 480 


Ala Ala Gln Ala Leu Glu Ser Gly Glu Glu Ala Asp Gly Asp Pro Thr 
                485                 490                 495     


His Asn Lys Asp Cys Asn Gly Ser Leu Asp Ala Ser Gly Glu Lys Gly 
            500                 505                 510         


Pro Pro Arg Pro Ser Cys Ser Ala Asp Ser Ala Ile Ser Asp Ala Met 
        515                 520                 525             


Glu Glu Leu Glu Glu Ala His Gln Lys Cys Pro Pro Trp Trp Tyr Lys 
    530                 535                 540                 


Cys Ala His Lys Val Leu Ile Trp Asn Cys Cys Ala Pro Trp Val Lys 
545                 550                 555                 560 


Phe Lys His Ile Ile Tyr Leu Ile Val Met Asp Pro Phe Val Asp Leu 
                565                 570                 575     


Gly Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu 
            580                 585                 590         


His Tyr Pro Met Thr Glu His Phe Asp Asn Val Leu Ser Val Gly Asn 
        595                 600                 605             


Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Val Leu Lys Leu Ile 
    610                 615                 620                 


Ala Met Asp Pro Tyr Glu Tyr Phe Gln Gln Gly Trp Asn Ile Phe Asp 
625                 630                 635                 640 


Ser Phe Ile Val Thr Leu Ser Leu Val Glu Leu Gly Leu Ala Asn Val 
                645                 650                 655     


Gln Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys 
            660                 665                 670         


Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly 
        675                 680                 685             


Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile 
    690                 695                 700                 


Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr 
705                 710                 715                 720 


Lys Glu Cys Val Cys Lys Ile Ala Ser Asp Cys Asn Leu Pro Arg Trp 
                725                 730                 735     


His Met Asn Asp Phe Phe His Ser Phe Leu Ile Val Phe Arg Ile Leu 
            740                 745                 750         


Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly 
        755                 760                 765             


Gln Ala Met Cys Leu Thr Val Phe Leu Met Val Met Val Ile Gly Asn 
    770                 775                 780                 


Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser 
785                 790                 795                 800 


Ala Asp Ser Leu Ala Ala Ser Asp Glu Asp Gly Glu Met Asn Asn Leu 
                805                 810                 815     


Gln Ile Ala Ile Gly Arg Ile Lys Trp Gly Ile Gly Phe Ala Lys Thr 
            820                 825                 830         


Phe Leu Leu Gly Leu Leu Arg Gly Lys Ile Leu Ser Pro Lys Glu Ile 
        835                 840                 845             


Ile Leu Ser Leu Gly Glu Pro Gly Gly Ala Gly Glu Asn Ala Glu Glu 
    850                 855                 860                 


Ser Thr Pro Glu Asp Glu Lys Lys Glu Pro Pro Pro Glu Asp Lys Glu 
865                 870                 875                 880 


Leu Lys Asp Asn His Ile Leu Asn His Val Gly Leu Thr Asp Gly Pro 
                885                 890                 895     


Arg Ser Ser Ile Glu Leu Asp His Leu Asn Phe Ile Asn Asn Pro Tyr 
            900                 905                 910         


Leu Thr Ile Gln Val Pro Ile Ala Ser Glu Glu Ser Asp Leu Glu Met 
        915                 920                 925             


Pro Thr Glu Glu Glu Thr Asp Ala Phe Ser Glu Pro Glu Asp Ile Lys 
    930                 935                 940                 


Lys Pro Leu Gln Pro Leu Tyr Asp Gly Asn Ser Ser Val Cys Ser Thr 
945                 950                 955                 960 


Ala Asp Tyr Lys Pro Pro Glu Glu Asp Pro Glu Glu Gln Ala Glu Glu 
                965                 970                 975     


Asn Pro Glu Gly Glu Gln Pro Glu Glu Cys Phe Thr Glu Ala Cys Val 
            980                 985                 990         


Lys Arg Cys Pro Cys Leu Tyr Val  Asp Ile Ser Gln Gly  Arg Gly Lys 
        995                 1000                 1005             


Met Trp  Trp Thr Leu Arg Arg  Ala Cys Phe Lys Ile  Val Glu His 
    1010                 1015                 1020             


Asn Trp  Phe Glu Thr Phe Ile  Val Phe Met Ile Leu  Leu Ser Ser 
    1025                 1030                 1035             


Gly Ala  Leu Ala Phe Glu Asp  Ile Tyr Ile Glu Gln  Arg Arg Val 
    1040                 1045                 1050             


Ile Arg  Thr Ile Leu Glu Tyr  Ala Asp Lys Val Phe  Thr Tyr Ile 
    1055                 1060                 1065             


Phe Ile  Leu Glu Met Leu Leu  Lys Trp Val Ala Tyr  Gly Phe Lys 
    1070                 1075                 1080             


Val Tyr  Phe Thr Asn Ala Trp  Cys Trp Leu Asp Phe  Leu Ile Val 
    1085                 1090                 1095             


Asp Val  Ser Ile Ile Ser Leu  Val Ala Asn Trp Leu  Gly Tyr Ser 
    1100                 1105                 1110             


Glu Leu  Gly Pro Ile Lys Ser  Leu Arg Thr Leu Arg  Ala Leu Arg 
    1115                 1120                 1125             


Pro Leu  Arg Ala Leu Ser Arg  Phe Glu Gly Met Arg  Val Val Val 
    1130                 1135                 1140             


Asn Ala  Leu Leu Gly Ala Ile  Pro Ser Ile Met Asn  Val Leu Leu 
    1145                 1150                 1155             


Val Cys  Leu Ile Phe Trp Leu  Ile Phe Ser Ile Met  Gly Val Asn 
    1160                 1165                 1170             


Leu Phe  Ala Gly Lys Phe Tyr  Tyr Cys Val Asn Thr  Thr Thr Ser 
    1175                 1180                 1185             


Glu Arg  Phe Asp Ile Ser Val  Val Asn Asn Lys Ser  Glu Ser Glu 
    1190                 1195                 1200             


Ser Leu  Met Tyr Thr Gly Gln  Val Arg Trp Met Asn  Val Lys Val 
    1205                 1210                 1215             


Asn Tyr  Asp Asn Val Gly Leu  Gly Tyr Leu Ser Leu  Leu Gln Val 
    1220                 1225                 1230             


Ala Thr  Phe Lys Gly Trp Met  Asp Ile Met Tyr Ala  Ala Val Asp 
    1235                 1240                 1245             


Ser Arg  Glu Lys Glu Glu Gln  Pro His Tyr Glu Val  Asn Leu Tyr 
    1250                 1255                 1260             


Met Tyr  Leu Tyr Phe Val Ile  Phe Ile Ile Phe Gly  Ser Phe Phe 
    1265                 1270                 1275             


Thr Leu  Asn Leu Phe Ile Gly  Val Ile Ile Asp Asn  Phe Asn Gln 
    1280                 1285                 1290             


Gln Lys  Lys Lys Phe Gly Gly  Lys Asp Ile Phe Met  Thr Glu Glu 
    1295                 1300                 1305             


Gln Lys  Lys Tyr Tyr Asn Ala  Met Lys Lys Leu Gly  Ser Lys Lys 
    1310                 1315                 1320             


Pro Gln  Lys Pro Ile Pro Arg  Pro Gln Asn Lys Ile  Gln Gly Met 
    1325                 1330                 1335             


Val Tyr  Asp Phe Val Thr Lys  Gln Val Phe Asp Ile  Ser Ile Met 
    1340                 1345                 1350             


Ile Leu  Ile Cys Leu Asn Met  Val Thr Met Met Val  Glu Thr Asp 
    1355                 1360                 1365             


Asp Gln  Ser Gln Leu Lys Val  Asp Ile Leu Tyr Asn  Ile Asn Met 
    1370                 1375                 1380             


Val Phe  Ile Ile Ile Phe Thr  Gly Glu Cys Val Leu  Lys Met Phe 
    1385                 1390                 1395             


Ala Leu  Arg His Tyr Tyr Phe  Thr Ile Gly Trp Asn  Ile Phe Asp 
    1400                 1405                 1410             


Phe Val  Val Val Ile Leu Ser  Ile Val Gly Leu Ala  Leu Ser Asp 
    1415                 1420                 1425             


Leu Ile  Gln Lys Tyr Phe Val  Ser Pro Thr Leu Phe  Arg Val Ile 
    1430                 1435                 1440             


Arg Leu  Ala Arg Ile Gly Arg  Val Leu Arg Leu Ile  Arg Gly Ala 
    1445                 1450                 1455             


Lys Gly  Ile Arg Thr Leu Leu  Phe Ala Leu Met Met  Ser Leu Pro 
    1460                 1465                 1470             


Ala Leu  Phe Asn Ile Gly Leu  Leu Leu Phe Leu Val  Met Phe Ile 
    1475                 1480                 1485             


Tyr Ser  Ile Phe Gly Met Ser  Asn Phe Ala Tyr Val  Lys Lys Glu 
    1490                 1495                 1500             


Ser Gly  Ile Asp Asp Met Phe  Asn Phe Glu Thr Phe  Gly Asn Ser 
    1505                 1510                 1515             


Ile Ile  Cys Leu Phe Glu Ile  Thr Thr Ser Ala Gly  Trp Asp Gly 
    1520                 1525                 1530             


Leu Leu  Asn Pro Ile Leu Asn  Ser Gly Pro Pro Asp  Cys Asp Pro 
    1535                 1540                 1545             


Thr Leu  Glu Asn Pro Gly Thr  Asn Val Arg Gly Asp  Cys Gly Asn 
    1550                 1555                 1560             


Pro Ser  Ile Gly Ile Cys Phe  Phe Cys Ser Tyr Ile  Ile Ile Ser 
    1565                 1570                 1575             


Phe Leu  Ile Val Val Asn Met  Tyr Ile Ala Ile Ile  Leu Glu Asn 
    1580                 1585                 1590             


Phe Asn  Val Ala Thr Glu Glu  Ser Ser Glu Pro Leu  Ser Glu Asp 
    1595                 1600                 1605             


Asp Phe  Glu Met Phe Tyr Glu  Thr Trp Glu Lys Phe  Asp Pro Asp 
    1610                 1615                 1620             


Ala Thr  Gln Phe Ile Asp Tyr  Ser Arg Leu Ser Asp  Phe Val Asp 
    1625                 1630                 1635             


Thr Leu  Gln Glu Pro Leu Lys  Ile Ala Lys Pro Asn  Lys Ile Lys 
    1640                 1645                 1650             


Leu Ile  Thr Leu Asp Leu Pro  Met Val Pro Gly Asp  Lys Ile His 
    1655                 1660                 1665             


Cys Leu  Asp Ile Leu Phe Ala  Leu Thr Lys Glu Val  Leu Gly Asp 
    1670                 1675                 1680             


Ser Gly  Glu Met Asp Ala Leu  Lys Gln Thr Met Glu  Glu Lys Phe 
    1685                 1690                 1695             


Met Ala  Ala Asn Pro Ser Lys  Val Ser Tyr Glu Pro  Ile Thr Thr 
    1700                 1705                 1710             


Thr Leu  Lys Arg Lys Gln Glu  Glu Val Cys Ala Ile  Lys Ile Gln 
    1715                 1720                 1725             


Arg Ala  Tyr Arg Arg His Leu  Leu Gln Arg Ser Val  Lys Gln Ala 
    1730                 1735                 1740             


Ser Tyr  Met Tyr Arg His Ser  Gln Asp Gly Asn Asp  Asp Gly Ala 
    1745                 1750                 1755             


Pro Glu  Lys Glu Gly Leu Leu  Ala Asn Thr Met Asn  Lys Met Tyr 
    1760                 1765                 1770             


Gly His  Glu Lys Glu Gly Asp  Gly Val Gln Ser Gln  Gly Glu Glu 
    1775                 1780                 1785             


Glu Lys  Ala Ser Thr Glu Asp  Ala Gly Pro Thr Val  Glu Pro Glu 
    1790                 1795                 1800             


Pro Thr  Ser Ser Ser Asp Thr  Ala Leu Thr Pro Ser  Pro Pro Pro 
    1805                 1810                 1815             


Leu Pro  Pro Ser Ser Ser Pro  Pro Gln Gly Gln Thr  Val Arg Pro 
    1820                 1825                 1830             


Gly Val  Lys Glu Ser Leu Val  
    1835                 1840 


<210>  14
<211>  6957
<212>  DNA
<213>  Rattus norvegicus


<220>
<221>  misc_feature
<222>  (1)..(6957)
<223>  nucleic acid sequence encoding  NCBI Reference Sequence: 
       NM_013178.1

<400>  14
acggcacccg gggctcgtcc gccaccgctc ttctctgctt ctggccaaca gctgaagtca       60

cgcagttcct ggagtctgaa cccaggagac agttcgggac actggggcgt tggccccaag      120

ctcctcgggc tggagaagat ctggttcact ttctgttgat cccgaaggtg gcacaatcta      180

ttgctgagaa gagaacactg cggggcctgg agtgggggaa tgcaccgtgc ccagtgtcct      240

gggcatcagc acgcccaggt cttgcaggca catctcccag ccccaacaag accaggacac      300

ccacctccct gacccaactc ctgggcaggc agagagtgag gagtacacag tagaccccgg      360

gcattggtga ccacccaaaa cccaagggct gcgggctgta gcggctctgt tacctaccac      420

cctctggccc ctgagcccag aatgcaagga tggccagctc atctctgccc aacctggtcc      480

ccccgggtcc ccactgcctg cgccccttca ccccagagtc cctggcagcc atagagcagc      540

gggcggtgga ggaggaggcc cggctgcagc ggaacaagca gatggagatt gaggagcctg      600

agcggaagcc acgcagtgac ctggaagctg gcaagaacct cccactcatc tatggggacc      660

ccccacccga agtcattggc atccccctgg aggacctgga tccttactac agtgacaaga      720

agaccttcat tgtgctcaac aaaggaaagg ccatcttccg attctctgcc acgcctgccc      780

tctacctgct gagccccttc agcatcgtca ggagggtggc tatcaaggtg ctcattcacg      840

cgctgttcag catgtttatc atgatcacca tcctgaccaa ctgtgtgttc atgaccatga      900

gcaatccgcc ttcttggtcc aaacacgtgg agtacacctt cacggggatc tatacctttg      960

agtccctcat taagatgctg gcccgaggct tttgcattga tgacttcaca ttcctccgag     1020

acccctggaa ctggctggac ttcagtgtca tcacaatggc gtatgtgaca gagtttgtgg     1080

acttgggcaa catctcagcc ctgaggacct tccgtgtgct gcgggccctg aagaccatca     1140

cggttatccc agggctgaag acaattgtgg gagccctgat ccagtctgtg aaaaagctgt     1200

cggatgtgat gatcctcact gtcttctgcc tgagtgtctt tgccctggtg gggctgcagc     1260

ttttcatggg aaacctgcgt cagaagtgcg tgcgttggcc cccgcccatg aatgacacca     1320

acaccacgtg gtatggcaat gacacttggt acagcaatga cacttggtac ggcaatgaca     1380

cttggtacat caatgacact tggaacagcc aggagagctg ggccggcaac tctacctttg     1440

actgggaggc ctacatcaat gacgaaggga acttctattt cttggagggc tccaatgatg     1500

ctctgctctg tgggaatagc agtgatgctg ggcactgccc tgagggctac gaatgcataa     1560

aggctgggcg gaaccccaac tatggctaca ccagctatga caccttcagc tgggctttcc     1620

tggctctctt ccggctcatg acgcaggact actgggagaa ccttttccag ctgaccctac     1680

gagctgctgg caagacctac atgatcttct tcgtggtcat catcttcctg ggctccttct     1740

acctcatcaa tctgatcctg gccgtggtgg ccatggcgta cgctgagcag aatgaggcta     1800

ccctggccga agaccaggag aaagaggagg agttccaaca gatgcttgag aaatacaaaa     1860

aacatcagga ggaactggaa aaggctaagg ctgcccaggc tctggaaagt ggagaggagg     1920

cagatgggga cccaacccac aacaaagact gcaatgggag cctggatgca tccggggaga     1980

aggggccccc aaggccaagc tgcagcgcag acagtgccat ctcagatgct atggaggagc     2040

tggaagaggc ccatcagaag tgcccaccgt ggtggtacaa gtgtgcacac aaagtcctca     2100

tctggaactg ctgtgccccg tgggtgaagt tcaaacatat aatctacctg atcgtcatgg     2160

acccctttgt ggacctgggt atcaccatct gcattgtgct caacaccctc ttcatggcca     2220

tggagcacta ccccatgacc gagcactttg acaacgtgct ctccgtgggc aacttggtct     2280

tcacaggcat cttcactgcg gagatggtgt tgaagctgat tgccatggac ccctacgagt     2340

atttccaaca gggctggaac atctttgaca gtttcatcgt caccctcagc ctggtggagc     2400

tgggcctggc caacgtacag gggctgtcag tgctccgttc cttccgcctg ctgcgtgtct     2460

tcaagctggc caagtcatgg ccaacactca acatgctcat caaaatcatt ggcaactcag     2520

tgggcgcgct gggcaacctg accctggtgc tggccatcat cgtcttcatc ttcgccgtgg     2580

tgggcatgca gctgttcggc aagagctata aggagtgtgt gtgcaagatc gcctcagact     2640

gcaacctgcc tcgctggcac atgaacgact tcttccactc cttcctcatc gtcttccgca     2700

tcctctgcgg ggaatggatc gagaccatgt gggactgcat ggaggtggcc ggccaggcca     2760

tgtgcctcac cgtcttcctc atggtcatgg tcattggcaa cctggtggtc ctgaatctgt     2820

tcctggctct cctgctgagt tccttcagtg ctgacagcct ggcggcctcg gatgaggatg     2880

gcgagatgaa caacctacag attgccatcg ggcgtatcaa gtggggcatc ggttttgcca     2940

aaaccttcct cctggggctg ttgcgtggca agatcctgag ccccaaggaa ataatactca     3000

gcctcggtga gcccgggggt gccggggaaa atgccgagga gagtactccc gaggatgaga     3060

agaaggagcc gccaccggaa gataaggagc tgaaagacaa tcatatcctg aaccacgtgg     3120

gcctgaccga tggcccccgc tccagcatcg agctggacca ccttaacttc atcaacaacc     3180

cctacctcac catccaggtg cccattgcct ccgaggagtc tgacctggag atgcccacag     3240

aggaggagac agacgccttc tcggagcctg aggatatcaa gaagccccta cagcccctct     3300

acgacgggaa ctcctccgtc tgcagcacag ctgactacaa gccccctgaa gaggaccccg     3360

aggagcaggc tgaggagaac cccgaggggg agcagcctga ggaatgcttc acggaagcct     3420

gtgtgaagcg ctgcccctgc ctctatgtgg acatctccca gggccgtggg aaaatgtggt     3480

ggacactgcg cagggcctgt ttcaagattg ttgagcacaa ctggtttgag accttcattg     3540

tcttcatgat cttgctcagc agtggagccc tggccttcga ggacatctac attgaacagc     3600

gacgagtcat ccgcaccatc ctggaatacg ccgacaaggt cttcacctac atcttcatcc     3660

tggagatgtt gctaaagtgg gtcgcctacg gcttcaaggt gtatttcacc aatgcctggt     3720

gctggctcga cttcctcatc gtggacgtct ccatcatcag cctggtggca aactggctgg     3780

gctactctga gctggggccc atcaaatccc tgcgcacact ccgggccctg cgacctctga     3840

gggcactgtc tcgatttgag ggtatgaggg tggtggtgaa cgccctcctg ggagctatcc     3900

cctccatcat gaacgtcctc ctcgtctgcc tcatcttctg gctcatcttc agcatcatgg     3960

gggtcaactt gtttgctgga aagttctact actgcgtcaa caccaccacc tctgagagat     4020

tcgacatctc ggtggtcaac aacaagtccg agtctgagag cctcatgtat acaggccagg     4080

tccgctggat gaatgtcaag gtcaactacg acaacgtggg tctgggctat ctctccctcc     4140

ttcaggtggc cacattcaag ggttggatgg atatcatgta tgcagctgtg gactcccggg     4200

agaaagagga gcagccacac tatgaggtga acctctacat gtacctctac ttcgtcatct     4260

tcatcatctt cggctccttc ttcaccctca acctcttcat cggtgtcatc atcgacaact     4320

tcaaccaaca gaagaagaag tttggaggga aagacatctt catgacagag gaacagaaga     4380

aatactacaa tgcgatgaag aagcttggct ccaagaagcc ccagaagcca attccccggc     4440

ctcagaacaa gatccagggc atggtgtacg acttcgtgac gaagcaggtg tttgacatct     4500

ccatcatgat cctcatctgc ctcaacatgg ttactatgat ggtggagaca gatgaccaga     4560

gccagctcaa ggtggacatc ctgtacaaca tcaacatggt cttcattatc atcttcacag     4620

gggagtgtgt gctgaagatg tttgccctac gccattacta cttcaccatt ggctggaaca     4680

tctttgactt tgtggttgtc atcttgtcca tcgtgggcct tgcgctctct gacttgatac     4740

agaaatactt tgtgtcaccc acgctgttcc gtgtgatccg cttggctcgg atcgggcgtg     4800

tcctgcgtct gatccgcggg gccaagggca tccggacgct gctgttcgcc ctgatgatgt     4860

ccctgcccgc cctcttcaac atcggcctcc ttctctttct ggtcatgttc atctactcga     4920

tcttcggcat gtctaacttc gcctacgtca agaaagagtc aggcatcgac gacatgttta     4980

actttgagac ctttggcaac agtatcatct gcctcttcga gatcaccacg tcagccggct     5040

gggacgggct tctgaacccc atcctcaaca gtgggccccc agactgtgac ccgacgttgg     5100

agaacccggg taccaatgtc aggggggact gcggcaaccc ttccatcggc atctgtttct     5160

tctgcagcta catcatcatc tccttcctca tcgtggtcaa catgtacatt gctatcatcc     5220

tggagaattt caacgtggcc accgaagaga gcagcgagcc cctcagtgag gatgacttcg     5280

agatgttcta tgagacctgg gagaagttcg acccggacgc cactcagttc atcgactaca     5340

gccgcctctc ggactttgtg gacaccctgc aggagccact gaaaatcgcc aaacccaata     5400

agatcaagct tatcacgtta gacctgccca tggtgcccgg cgacaagatc cactgcttgg     5460

acatcctctt tgccctgacc aaagaggtac tgggtgactc tggggagatg gacgccctca     5520

agcagaccat ggaggagaag tttatggcag ctaacccttc caaggtctcc tatgagccca     5580

tcaccaccac cctcaagagg aagcaggagg aggtgtgtgc tatcaaaatc cagagggcct     5640

accgccgcca cctgctgcag cgctccgtga agcaggcctc ttacatgtac cgtcacagcc     5700

aggacggcaa tgacgacggg gcccccgaga aggagggatt gcttgccaac accatgaaca     5760

agatgtatgg ccatgagaaa gagggtgatg gtgtgcagag ccagggggag gaagagaagg     5820

cctctacaga ggatgctgga cccaccgtgg agcccgaacc caccagcagc tcagatactg     5880

ccctgactcc ttctcctcca ccactacccc cctcatcatc accgccacaa gggcagacag     5940

ttcgcccagg ggtcaaagag tctcttgtct agatggcagc gtcaaggctg cacgcagagt     6000

tggaggggaa gggctttgag atgggggcta tacaggactt gacacctggg ctgaggggta     6060

tggaaattgt gctcagggtt caggtgggtc ggaagcccct gctgcctgat ttcatcttta     6120

cgatgctctg acattctgtt ggccagggga ggccaggaca tctgaatgct gtttccttct     6180

tgggggagag ccagcatacc ttggaggggt tggccacctt cctgtcacta ctttaagggc     6240

ccaggacccc agctctagcc aagacaaaga cgaatcttaa cccccaaacc tacacctgac     6300

ccccagagct tagctatccc tctcgccccc ataattctag ggtgcagctt ccccctgaca     6360

gctcaggaat gccctgtaaa aggggaaatg gttctggtac agaaccaatt ggccgctgga     6420

tccggatgta tcaggctgga aacatgactt ctgaaacctt tcacccagtc agatccaggc     6480

cggtgggcag ctcccctggc tggcccctgg gggaagaact aaggaaggat tgccctgaga     6540

aattaccttt ctctagattg cgtggatggg tcaaacaggc tgggtcctgc cagctgcatt     6600

catgcccttg agcctgagcg cccacatctg cctggggtca ggttggaagc tctctatcaa     6660

gaatcgcccg ttcccgcctc cctgccttct ttctttgaat accagggctc ctgggagccc     6720

catcaaacac gaaagactgc cttcctcctg tctaatctct gcccccccct tccctgcccc     6780

ttccctgctt cctcaagtga ctctgagaat gctagaactc agcacacggg agatgagttg     6840

atactggggc atgcagtgag aaggctcacc aggcttggct ttggtcttct cattgcctga     6900

aagcaagttt tcccctgaga cagggtttct tttctccgtg tagccctggc tgcctgg        6957


<210>  15
<211>  1836
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1836)
<223>  amino acid sequence for Homo sapiens skeletal muscle 
       voltage-dependent sodium channel alpha subunit (SkM1)

<400>  15

Met Ala Arg Pro Ser Leu Cys Thr Leu Ala Arg Leu Gly Pro Glu Cys 
1               5                   10                  15      


Leu Arg Pro Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Gln Arg Ala 
            20                  25                  30          


Val Glu Glu Glu Ala Arg Leu Gln Arg Asn Lys Gln Met Glu Ile Glu 
        35                  40                  45              


Glu Pro Glu Arg Lys Pro Arg Ser Asp Leu Glu Ala Gly Lys Asn Leu 
    50                  55                  60                  


Pro Met Ile Tyr Gly Asp Pro Pro Pro Glu Val Ile Gly Ile Pro Leu 
65                  70                  75                  80  


Glu Asp Leu Asp Pro Tyr Tyr Ser Asn Lys Lys Thr Phe Ile Val Leu 
                85                  90                  95      


Asn Lys Gly Lys Ala Ile Phe Arg Phe Ser Ala Thr Pro Ala Leu Tyr 
            100                 105                 110         


Leu Leu Ser Pro Phe Ser Val Val Arg Arg Gly Ala Ile Lys Val Leu 
        115                 120                 125             


Ile His Ala Leu Phe Ser Met Phe Ile Met Ile Thr Ile Leu Thr Asn 
    130                 135                 140                 


Cys Val Phe Met Thr Met Ser Asp Pro Pro Pro Trp Ser Lys Asn Val 
145                 150                 155                 160 


Glu Tyr Thr Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile 
                165                 170                 175     


Leu Ala Arg Gly Phe Cys Val Asp Asp Phe Thr Phe Leu Arg Asp Pro 
            180                 185                 190         


Trp Asn Trp Leu Asp Phe Ser Val Ile Met Met Ala Tyr Leu Thr Glu 
        195                 200                 205             


Phe Val Asp Leu Gly Asn Ile Ser Ala Leu Arg Thr Phe Arg Val Leu 
    210                 215                 220                 


Arg Ala Leu Lys Thr Ile Thr Val Ile Pro Gly Leu Lys Thr Ile Val 
225                 230                 235                 240 


Gly Ala Leu Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu 
                245                 250                 255     


Thr Val Phe Cys Leu Ser Val Phe Ala Leu Val Gly Leu Gln Leu Phe 
            260                 265                 270         


Met Gly Asn Leu Arg Gln Lys Cys Val Arg Trp Pro Pro Pro Phe Asn 
        275                 280                 285             


Asp Thr Asn Thr Thr Trp Tyr Ser Asn Asp Thr Trp Tyr Gly Asn Asp 
    290                 295                 300                 


Thr Trp Tyr Gly Asn Glu Met Trp Tyr Gly Asn Asp Ser Trp Tyr Ala 
305                 310                 315                 320 


Asn Asp Thr Trp Asn Ser His Ala Ser Trp Ala Thr Asn Asp Thr Phe 
                325                 330                 335     


Asp Trp Asp Ala Tyr Ile Ser Asp Glu Gly Asn Phe Tyr Phe Leu Glu 
            340                 345                 350         


Gly Ser Asn Asp Ala Leu Leu Cys Gly Asn Ser Ser Asp Ala Gly His 
        355                 360                 365             


Cys Pro Lys Gly Tyr Glu Cys Ile Lys Thr Gly Arg Asn Pro Asn Tyr 
    370                 375                 380                 


Gly Tyr Thr Ser Tyr Asp Thr Phe Ser Trp Ala Phe Leu Ala Leu Phe 
385                 390                 395                 400 


Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Phe Gln Leu Thr Leu 
                405                 410                 415     


Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val Ile Ile Phe 
            420                 425                 430         


Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu Ala Val Val Ala Met 
        435                 440                 445             


Ala Tyr Ala Glu Gln Asn Glu Ala Thr Leu Ala Glu Asp Lys Glu Lys 
    450                 455                 460                 


Glu Glu Glu Phe Gln Gln Met Leu Glu Lys Phe Lys Lys His Gln Glu 
465                 470                 475                 480 


Glu Leu Glu Lys Ala Lys Ala Ala Gln Ala Leu Glu Gly Gly Glu Ala 
                485                 490                 495     


Asp Gly Asp Pro Ala His Gly Lys Asp Cys Asn Gly Ser Leu Asp Thr 
            500                 505                 510         


Ser Gln Gly Glu Lys Gly Ala Pro Arg Gln Ser Gly Ser Gly Asp Ser 
        515                 520                 525             


Gly Ile Ser Asp Ala Met Glu Glu Leu Glu Glu Ala His Gln Lys Cys 
    530                 535                 540                 


Pro Pro Trp Trp Tyr Lys Cys Ala His Lys Val Leu Ile Trp Asp Cys 
545                 550                 555                 560 


Cys Ala Pro Trp Leu Lys Phe Lys Asn Ile Ile His Leu Ile Val Met 
                565                 570                 575     


Asp Pro Phe Val Asp Leu Gly Ile Thr Ile Cys Ile Val Leu Asn Thr 
            580                 585                 590         


Leu Phe Met Ala Met Glu His Tyr Pro Met Thr Glu His Phe Asp Asn 
        595                 600                 605             


Val Leu Thr Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu 
    610                 615                 620                 


Met Val Leu Lys Leu Ile Ala Met Asp Pro Tyr Glu Tyr Phe Gln Gln 
625                 630                 635                 640 


Gly Trp Asn Ile Phe Asp Ser Ile Ile Val Thr Leu Ser Leu Val Glu 
                645                 650                 655     


Leu Gly Leu Ala Asn Val Gln Gly Leu Ser Val Leu Arg Ser Phe Arg 
            660                 665                 670         


Leu Leu Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met 
        675                 680                 685             


Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr 
    690                 695                 700                 


Leu Val Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln 
705                 710                 715                 720 


Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val Cys Lys Ile Ala Leu Asp 
                725                 730                 735     


Cys Asn Leu Pro Arg Trp His Met His Asp Phe Phe His Ser Phe Leu 
            740                 745                 750         


Ile Val Phe Arg Ile Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp 
        755                 760                 765             


Cys Met Glu Val Ala Gly Gln Ala Met Cys Leu Thr Val Phe Leu Met 
    770                 775                 780                 


Val Met Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu 
785                 790                 795                 800 


Leu Leu Ser Ser Phe Ser Ala Asp Ser Leu Ala Ala Ser Asp Glu Asp 
                805                 810                 815     


Gly Glu Met Asn Asn Leu Gln Ile Ala Ile Gly Arg Ile Lys Leu Gly 
            820                 825                 830         


Ile Gly Phe Ala Lys Ala Phe Leu Leu Gly Leu Leu His Gly Lys Ile 
        835                 840                 845             


Leu Ser Pro Lys Asp Ile Met Leu Ser Leu Gly Glu Ala Asp Gly Ala 
    850                 855                 860                 


Gly Glu Ala Gly Glu Ala Gly Glu Thr Ala Pro Glu Asp Glu Lys Lys 
865                 870                 875                 880 


Glu Pro Pro Glu Glu Asp Leu Lys Lys Asp Asn His Ile Leu Asn His 
                885                 890                 895     


Met Gly Leu Ala Asp Gly Pro Pro Ser Ser Leu Glu Leu Asp His Leu 
            900                 905                 910         


Asn Phe Ile Asn Asn Pro Tyr Leu Thr Ile Gln Val Pro Ile Ala Ser 
        915                 920                 925             


Glu Glu Ser Asp Leu Glu Met Pro Thr Glu Glu Glu Thr Asp Thr Phe 
    930                 935                 940                 


Ser Glu Pro Glu Asp Ser Lys Lys Pro Pro Gln Pro Leu Tyr Asp Gly 
945                 950                 955                 960 


Asn Ser Ser Val Cys Ser Thr Ala Asp Tyr Lys Pro Pro Glu Glu Asp 
                965                 970                 975     


Pro Glu Glu Gln Ala Glu Glu Asn Pro Glu Gly Glu Gln Pro Glu Glu 
            980                 985                 990         


Cys Phe Thr Glu Ala Cys Val Gln  Arg Trp Pro Cys Leu  Tyr Val Asp 
        995                 1000                 1005             


Ile Ser  Gln Gly Arg Gly Lys  Lys Trp Trp Thr Leu  Arg Arg Ala 
    1010                 1015                 1020             


Cys Phe  Lys Ile Val Glu His  Asn Trp Phe Glu Thr  Phe Ile Val 
    1025                 1030                 1035             


Phe Met  Ile Leu Leu Ser Ser  Gly Ala Leu Ala Phe  Glu Asp Ile 
    1040                 1045                 1050             


Tyr Ile  Glu Gln Arg Arg Val  Ile Arg Thr Ile Leu  Glu Tyr Ala 
    1055                 1060                 1065             


Asp Lys  Val Phe Thr Tyr Ile  Phe Ile Met Glu Met  Leu Leu Lys 
    1070                 1075                 1080             


Trp Val  Ala Tyr Gly Phe Lys  Val Tyr Phe Thr Asn  Ala Trp Cys 
    1085                 1090                 1095             


Trp Leu  Asp Phe Leu Ile Val  Asp Val Ser Ile Ile  Ser Leu Val 
    1100                 1105                 1110             


Ala Asn  Trp Leu Gly Tyr Ser  Glu Leu Gly Pro Ile  Lys Ser Leu 
    1115                 1120                 1125             


Arg Thr  Leu Arg Ala Leu Arg  Pro Leu Arg Ala Leu  Ser Arg Phe 
    1130                 1135                 1140             


Glu Gly  Met Arg Val Val Val  Asn Ala Leu Leu Gly  Ala Ile Pro 
    1145                 1150                 1155             


Ser Ile  Met Asn Val Leu Leu  Val Cys Leu Ile Phe  Trp Leu Ile 
    1160                 1165                 1170             


Phe Ser  Ile Met Gly Val Asn  Leu Phe Ala Gly Lys  Phe Tyr Tyr 
    1175                 1180                 1185             


Cys Ile  Asn Thr Thr Thr Ser  Glu Arg Phe Asp Ile  Ser Glu Val 
    1190                 1195                 1200             


Asn Asn  Lys Ser Glu Cys Glu  Ser Leu Met His Thr  Gly Gln Val 
    1205                 1210                 1215             


Arg Trp  Leu Asn Val Lys Val  Asn Tyr Asp Asn Val  Gly Leu Gly 
    1220                 1225                 1230             


Tyr Leu  Ser Leu Leu Gln Val  Ala Thr Phe Lys Gly  Trp Met Asp 
    1235                 1240                 1245             


Ile Met  Tyr Ala Ala Val Asp  Ser Arg Glu Lys Glu  Glu Gln Pro 
    1250                 1255                 1260             


Gln Tyr  Glu Val Asn Leu Tyr  Met Tyr Leu Tyr Phe  Val Ile Phe 
    1265                 1270                 1275             


Ile Ile  Phe Gly Ser Phe Phe  Thr Leu Asn Leu Phe  Ile Gly Val 
    1280                 1285                 1290             


Ile Ile  Asp Asn Phe Asn Gln  Gln Lys Lys Lys Leu  Gly Gly Lys 
    1295                 1300                 1305             


Asp Ile  Phe Met Thr Glu Glu  Gln Lys Lys Tyr Tyr  Asn Ala Met 
    1310                 1315                 1320             


Lys Lys  Leu Gly Ser Lys Lys  Pro Gln Lys Pro Ile  Pro Arg Pro 
    1325                 1330                 1335             


Gln Asn  Lys Ile Gln Gly Met  Val Tyr Asp Leu Val  Thr Lys Gln 
    1340                 1345                 1350             


Ala Phe  Asp Ile Thr Ile Met  Ile Leu Ile Cys Leu  Asn Met Val 
    1355                 1360                 1365             


Thr Met  Met Val Glu Thr Asp  Asp Gln Ser Gln Leu  Lys Val Asp 
    1370                 1375                 1380             


Ile Leu  Tyr Asn Ile Asn Met  Ile Phe Ile Ile Ile  Phe Thr Gly 
    1385                 1390                 1395             


Glu Cys  Val Leu Lys Met Leu  Ala Leu Arg Gln Tyr  Tyr Phe Thr 
    1400                 1405                 1410             


Val Gly  Trp Asn Ile Phe Asp  Phe Val Val Val Ile  Leu Ser Ile 
    1415                 1420                 1425             


Val Gly  Leu Ala Leu Ser Asp  Leu Ile Gln Lys Tyr  Phe Val Ser 
    1430                 1435                 1440             


Pro Thr  Leu Phe Arg Val Ile  Arg Leu Ala Arg Ile  Gly Arg Val 
    1445                 1450                 1455             


Leu Arg  Leu Ile Arg Gly Ala  Lys Gly Ile Arg Thr  Leu Leu Phe 
    1460                 1465                 1470             


Ala Leu  Met Met Ser Leu Pro  Ala Leu Phe Asn Ile  Gly Leu Leu 
    1475                 1480                 1485             


Leu Phe  Leu Val Met Phe Ile  Tyr Ser Ile Phe Gly  Met Ser Asn 
    1490                 1495                 1500             


Phe Ala  Tyr Val Lys Lys Glu  Ser Gly Ile Asp Asp  Met Phe Asn 
    1505                 1510                 1515             


Phe Glu  Thr Phe Gly Asn Ser  Ile Ile Cys Leu Phe  Glu Ile Thr 
    1520                 1525                 1530             


Thr Ser  Ala Gly Trp Asp Gly  Leu Leu Asn Pro Ile  Leu Asn Ser 
    1535                 1540                 1545             


Gly Pro  Pro Asp Cys Asp Pro  Asn Leu Glu Asn Pro  Gly Thr Ser 
    1550                 1555                 1560             


Val Lys  Gly Asp Cys Gly Asn  Pro Ser Ile Gly Ile  Cys Phe Phe 
    1565                 1570                 1575             


Cys Ser  Tyr Ile Ile Ile Ser  Phe Leu Ile Val Val  Asn Met Tyr 
    1580                 1585                 1590             


Ile Ala  Ile Ile Leu Glu Asn  Phe Asn Val Ala Thr  Glu Glu Ser 
    1595                 1600                 1605             


Ser Glu  Pro Leu Gly Glu Asp  Asp Phe Glu Met Phe  Tyr Glu Thr 
    1610                 1615                 1620             


Trp Glu  Lys Phe Asp Pro Asp  Ala Thr Gln Phe Ile  Ala Tyr Ser 
    1625                 1630                 1635             


Arg Leu  Ser Asp Phe Val Asp  Thr Leu Gln Glu Pro  Leu Arg Ile 
    1640                 1645                 1650             


Ala Lys  Pro Asn Lys Ile Lys  Leu Ile Thr Leu Asp  Leu Pro Met 
    1655                 1660                 1665             


Val Pro  Gly Asp Lys Ile His  Cys Leu Asp Ile Leu  Phe Ala Leu 
    1670                 1675                 1680             


Thr Lys  Glu Val Leu Gly Asp  Ser Gly Glu Met Asp  Ala Leu Lys 
    1685                 1690                 1695             


Gln Thr  Met Glu Glu Lys Phe  Met Ala Ala Asn Pro  Ser Lys Val 
    1700                 1705                 1710             


Ser Tyr  Glu Pro Ile Thr Thr  Thr Leu Lys Arg Lys  His Glu Glu 
    1715                 1720                 1725             


Val Cys  Ala Ile Lys Ile Gln  Arg Ala Tyr Arg Arg  His Leu Leu 
    1730                 1735                 1740             


Gln Arg  Ser Met Lys Gln Ala  Ser Tyr Met Tyr Arg  His Ser His 
    1745                 1750                 1755             


Asp Gly  Ser Gly Asp Asp Ala  Pro Glu Lys Glu Gly  Leu Leu Ala 
    1760                 1765                 1770             


Asn Thr  Met Ser Lys Met Tyr  Gly His Glu Asn Gly  Asn Ser Ser 
    1775                 1780                 1785             


Ser Pro  Ser Pro Glu Glu Lys  Gly Glu Ala Gly Asp  Ala Gly Pro 
    1790                 1795                 1800             


Thr Met  Gly Leu Met Pro Ile  Ser Pro Ser Asp Thr  Ala Trp Pro 
    1805                 1810                 1815             


Pro Ala  Pro Pro Pro Gly Gln  Thr Val Arg Pro Gly  Val Lys Glu 
    1820                 1825                 1830             


Ser Leu  Val 
    1835     


<210>  16
<211>  7823
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(7823)
<223>  nucleic acid sequence for the corresponding GenBank: M81758.1

<400>  16
ccagcacccc ggggctgcgc actgcagctc cccaggccac ccaccaccct tctggtctct       60

gagcccagga tgcgaggatg gccagaccat ctctgtgcac cctggctcgt ctgggccctg      120

agtgcttgcg ccccttcacc cgggagtcac tggcagccat agaacagcgg gcggtggagg      180

aggaggcccg gctgcagcgg aataagcaga tggagattga ggagcccgaa cggaagccac      240

gaagtgactt ggaggctggc aagaacctac ccatgatcta cggagacccc ccgccggagg      300

tcatcggcat ccccctggag gacctggatc cctactacag caataagaag accttcatcg      360

tactcaacaa gggcaaggcc atcttccgct tctccgccac acctgctctc tacctgctga      420

gccccttcag cgtagtcagg cgcggggcca tcaaggtgct catccatgcg ctgttcagca      480

tgttcatcat gatcaccatc ttgaccaact gcgtattcat gaccatgagt gacccgcctc      540

cctggtccaa gaatgtggag tacaccttca cagggatcta cacctttgag tccctcatca      600

agatactggc ccgaggcttc tgtgtcgacg acttcacatt cctccgggac ccctggaact      660

ggctggactt cagtgtcatc atgatggcgt acctgacaga gtttgtggac ttgggcaaca      720

tctcagccct gaggaccttc cgggtgctgc gggccctcaa aaccatcacg gtcatcccag      780

ggctgaagac gatcgtgggg gccctgatcc agtcggtgaa gaagctgtcg gatgtgatga      840

tcctcactgt cttctgcctg agcgtctttg cgctggtagg actgcagctc ttcatgggaa      900

acctgaggca gaagtgtgtg cgctggcccc cgccgttcaa cgacaccaac accacgtggt      960

acagcaatga cacgtggtac ggcaatgaca catggtatgg caatgagatg tggtacggca     1020

atgactcatg gtatgccaac gacacgtgga acagccatgc aagctgggcc accaacgata     1080

cctttgattg ggacgcctac atcagtgatg aagggaactt ctacttcctg gagggctcca     1140

acgatgccct gctctgtggg aacagcagtg atgctgggca ctgccctaag ggttatgagt     1200

gcatcaagac cgggcggaac cccaactatg gctacaccag ctatgacacc ttcagctggg     1260

ccttcttggc tctcttccgc ctcatgacac aggactattg ggagaacctc ttccagctga     1320

cccttcgagc agctggcaag acctacatga tcttcttcgt ggtcatcatc ttcctgggct     1380

ctttctacct catcaatctg atcctggccg tggtggccat ggcatatgcc gagcagaatg     1440

aggccaccct ggccgaggat aaggagaaag aggaggagtt tcagcagatg cttgagaagt     1500

tcaaaaagca ccaggaggag ctggagaagg ccaaggccgc ccaagctctg gaaggtgggg     1560

aggcagatgg ggacccagcc catggcaaag actgcaatgg cagcctggac acatcgcaag     1620

gggagaaggg agccccgagg cagagcggca gcggagacag cggcatctcc gacgccatgg     1680

aagaactgga agaggcccac caaaagtgcc caccatggtg gtacaagtgc gcccacaaag     1740

tgctcatatg ggactgctgc gccccgtggc tgaagttcaa gaacatcatc cacctgatcg     1800

tcatggaccc gttcgtggac ctgggcatca ccatctgcat cgtgctcaac accctcttca     1860

tggccatgga acattacccc atgacggagc actttgacaa cgtgctcact gtgggcaacc     1920

tggtcttcac aggcatcttc acagcagaga tggttctgaa gctgattgcc atggacccct     1980

acgagtattt ccagcagggt tggaatatct tcgacagcat catcgtcacc ctcagcctgg     2040

tagagctagg cctggccaac gtacagggac tgtctgtgct acgctccttc cgtctgctgc     2100

gggtcttcaa gctggccaag tcgtggccaa cgctgaacat gctcatcaag atcattggca     2160

attcagtggg ggcgctgggt aacctgacgc tggtgctggc tatcatcgtg ttcatcttcg     2220

ccgtggtggg catgcagctg tttggcaaga gctacaagga gtgcgtgtgc aagattgcct     2280

tggactgcaa cctgccgcgc tggcacatgc atgatttctt ccactccttc ctcatcgtct     2340

tccgcatcct gtgcggggag tggatcgaga ccatgtggga ctgcatggag gtggccggcc     2400

aagccatgtg cctcaccgtc ttcctcatgg tcatggtcat cggcaatctt gtggtcctga     2460

acctgttcct ggctctgctg ctgagctcct tcagcgccga cagtctggca gcctcggatg     2520

aggatggcga gatgaacaac ctgcagattg ccatcgggcg catcaagttg ggcatcggct     2580

ttgccaaggc cttcctcctg gggctgctgc atggcaagat cctgagcccc aaggacatca     2640

tgctcagcct cggggaggct gacggggccg gggaggctgg agaggcgggg gagactgccc     2700

ccgaggatga gaagaaggag ccgcccgagg aggacctgaa gaaggacaat cacatcctga     2760

accacatggg cctggctgac ggccccccat ccagcctcga gctggaccac cttaacttca     2820

tcaacaaccc ctacctgacc atacaggtgc ccatcgcctc cgaggagtcc gacctggaga     2880

tgcccaccga ggaggaaacc gacactttct cagagcctga ggatagcaag aagccgccgc     2940

agcctctcta tgatgggaac tcgtccgtct gcagcacagc tgactacaag ccccccgagg     3000

aggaccctga ggagcaggca gaggagaacc ccgaggggga gcagcctgag gagtgcttca     3060

ctgaggcctg cgtgcagcgc tggccctgcc tctacgtgga catctcccag ggccgtggga     3120

agaagtggtg gactctgcgc agggcctgct tcaagattgt cgagcacaac tggttcgaga     3180

ccttcattgt cttcatgatc ctgctcagca gtggggctct ggccttcgag gacatctaca     3240

ttgagcagcg gcgagtcatt cgcaccatcc tagaatatgc cgacaaggtc ttcacctaca     3300

tcttcatcat ggagatgctg ctcaaatggg tggcctacgg ctttaaggtg tacttcacca     3360

acgcctggtg ctggctcgac ttcctcatcg tggatgtctc catcatcagc ttggtggcca     3420

actggctggg ctactcggag ctgggaccca tcaaatccct gcggacactg cgggccctgc     3480

gtcccctgag ggcactgtcc cgattcgagg gcatgagggt ggtggtgaac gccctcctag     3540

gcgccatccc ctccatcatg aatgtgctgc ttgtctgcct catcttctgg ctgatcttca     3600

gcatcatggg tgtcaacctg tttgccggca agttctacta ctgcatcaac accaccacct     3660

ctgagaggtt cgacatctcc gaggtcaaca acaagtctga gtgcgagagc ctcatgcaca     3720

caggccaggt ccgctggctc aatgtcaagg tcaactacga caacgtgggt ctgggctacc     3780

tctccctcct gcaggtggcc accttcaagg gttggatgga catcatgtat gcagccgtgg     3840

actcccggga gaaggaggag cagccgcagt acgaggtgaa cctctacatg tacctctact     3900

ttgtcatctt catcatcttt ggctccttct tcaccctcaa cctcttcatt ggcgtcatca     3960

ttgacaactt caaccagcag aagaagaagt taggggggaa agacatcttt atgacggagg     4020

aacagaagaa atactataac gccatgaaga agcttggctc caagaagcct cagaagccaa     4080

ttccccggcc ccagaacaag atccagggca tggtgtatga cctcgtgacg aagcaggcct     4140

tcgacatcac catcatgatc ctcatctgcc tcaacatggt caccatgatg gtggagacag     4200

acgaccagag ccagctcaag gtggacatcc tgtacaacat caacatgatc ttcatcatca     4260

tcttcacagg ggagtgcgtg ctcaagatgc tcgccctgcg ccagtactac ttcaccgttg     4320

gctggaacat ctttgacttc gtggtcgtca tcctgtccat tgtgggcctt gccctctctg     4380

acctgatcca gaagtacttc gtgtcaccca cgctgttccg tgtgatccgc ctggcgcgga     4440

ttgggcgtgt cctgcggctg atccgcgggg ccaagggcat ccggacgctg ctgttcgccc     4500

tcatgatgtc gctgcctgcc ctcttcaaca tcggcctcct cctcttcctg gtcatgttca     4560

tctactccat cttcggcatg tccaactttg cctacgtcaa gaaggagtcg ggcatcgatg     4620

atatgttcaa cttcgagacc ttcggcaaca gcatcatctg cctgttcgag atcaccacgt     4680

cggccggctg ggacgggctc ctcaacccca tcctcaacag cgggccccca gactgtgacc     4740

ccaacctgga gaacccgggc accagtgtca agggtgactg cggcaacccc tccatcggca     4800

tctgcttctt ctgcagctat atcatcatct ccttcctcat cgtggtcaac atgtacatcg     4860

ccatcatcct ggagaacttc aatgtggcca cagaggagag cagcgagccc cttggtgaag     4920

atgactttga gatgttctac gagacatggg agaagttcga ccccgacgcc acccagttca     4980

tcgcctacag ccgcctctca gacttcgtgg acaccctgca ggaaccgctg aggattgcca     5040

agcccaacaa gatcaagctc atcacactgg acttgcccat ggtgccaggg gacaagatcc     5100

actgcctgga catcctcttt gccctgacca aagaggtcct gggtgactct ggggaaatgg     5160

acgccctcaa gcagaccatg gaggagaagt tcatggcagc caacccctcc aaggtgtcct     5220

acgagcccat caccaccacc ctcaagagga agcacgagga ggtgtgcgcc atcaagatcc     5280

agagggccta ccgccggcac ctgctacagc gctccatgaa gcaggcatcc tacatgtacc     5340

gccacagcca cgacggcagc ggggatgacg cccctgagaa ggaggggctg cttgccaaca     5400

ccatgagcaa gatgtatggc cacgagaatg ggaacagcag ctcgccaagc ccggaggaga     5460

agggcgaggc aggggacgcc ggacccacta tggggctgat gcccatcagc ccctcagaca     5520

ctgcctggcc tcccgcccct cccccagggc agactgtgcg cccaggtgtc aaggagtctc     5580

ttgtctagca ggcagcatcg gggtggcccc actgagtctc ggcatagtcc ccagagctcc     5640

cccgtggtgc ctgcacacag agtgagggag gagggctttg aatctgggac tgtgcctggc     5700

tccctgatgg gggacaggat ttggccacac tggggctgac acccaggccc gagcgcctgc     5760

gttcccagac catgggaaat gggaattgcg ctcaggggct ccatgctggg tctgaggccc     5820

ctgcctccaa gatttaacct gcaagttgct ctgacctcct ctgggccctg tcgcccctcc     5880

ttttggcctg ggggaggtca gaacattcga atctctgccc ctcacttgag gaggagctgg     5940

cctgcggtgg agggatcagt tgccccccat caccagagtc ttaagggtca ctggcctctc     6000

cccaggaagt gggctcagac ccccctcagc cccagcccag acaaagatgt cttaacctca     6060

gggagtgcag acacctaacc ccagggcact gccagcccac cccctttgac tctggggtgc     6120

agcttcaccc accaggccag ctcaggaatt ccctggaaaa gggaaatgtg actggttcag     6180

aaatagctcc tcaaagcctc aaaacctgat tggccactgg atcctgctgc tttgggctgg     6240

gatggtgact cctgaaacct cttcctaggc cacgtccagg tccgtagctc ccctggctgg     6300

ctcctagggg aagagcagaa ggaaggatgc cacttgggaa tgaattgtcc ttttctagga     6360

agcacggggg agtgagacag gctgggtcct gccagctgga tcgctgcaca tggcctgagc     6420

atccagacct gagcgggagt cagggacctg ctgctcagta agaagattct cgccccttcc     6480

ctctctccct gcctcactcc tccgtgagca ccaccagggc tccaggagcc tcatccagcc     6540

tcagagatct cccttctcat ctccccacgc cccgtctctt tctcaccttt cccacctctc     6600

tccccaaagt gatcctaaga atgtacagtt gagctcaggt tagatatttc gaccctgggg     6660

cgtgcagcag ggaaggccca actggttcag gctcaacctt ccaacttcct gtggcctgaa     6720

gaagcacttc tgctgcatcg ctgttctggg catggcaggg ccaggcctct gctggctcag     6780

gaggaggggt gagagacctg ctcaggcgtc gctggattta ttcacttgtg tgtgtacctg     6840

tggctgtgtg tctgcttgta tgcttttata ggcctgtgtg tatagctgtg tgtgtgttca     6900

agtgcgtgac tgtatgtgtg tgtgtgaacc actgtgtgaa ccactgtgta ctggagcctg     6960

cattatgcac gtgtctgggt atctttgtat atatgtgtat atatgtgtgc cctggactgt     7020

ttcaaggtcc atggagtacg gctggtgtgt catactgtgc aggcctgtcc ctgggagtgt     7080

tcccgtgcct gggagagtgg acctgtgctg tgagtgtgtg gatgcgtgtg aacgcatgtg     7140

gtaaggtgtg tactcagggc attctgttgg cctaagtgcc tcttcttttt cttcttgttt     7200

ctcatgaaaa gtttgattaa aattcaggaa gcagcaaaac cttcaaaaca agacatgtat     7260

gtgtgcttga gtgtgtgaac acgtgtgtgt gtgtgcacat ctacatgcca tgcctatggg     7320

ccagagttgt ctttattgtc caccatgctc tctcacctgc ttcccagtcc tgcctgaaca     7380

gccctctctc tcactcccct ctcctcccct tcctgtttct cgttgtcaca cccatggcct     7440

cagccctgct ccctgcctcc tgcctatgtc tcctctatgg aaggaggcct ccactccttc     7500

catctcttcc ttcagaagtt tcgtctaatg ggggcagtct ccccttcctg gcacattgcc     7560

cctctgcctt gccctcctgg gccctgggct ggcacagccc ctggagcctc agaaatctgt     7620

ttgattggat attctcctcg gactgtgtgc aggttgcaga ggaagagtag atgagccggg     7680

tccggcctct ccctgcctgt ggcccctccc ctgcagacgg atgcccattc ctgcctggtc     7740

cagtggggaa caggtcccac gccaggccag caggcgggct cctttgtaca gttcttacaa     7800

taaaccctcc ttggtgcctc tgg                                             7823


<210>  17
<211>  8133
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(8133)
<223>  Homo sapienssodium channel, voltage-gated, type I, alpha subunit 
       (SCN1A), transcript variant 1

<400>  17
aatgtgcagg atgacaagat ggagcaaaca gtgcttgtac caccaggacc tgacagcttc       60

aacttcttca ccagagaatc tcttgcggct attgaaagac gcattgcaga agaaaaggca      120

aagaatccca aaccagacaa aaaagatgac gacgaaaatg gcccaaagcc aaatagtgac      180

ttggaagctg gaaagaacct tccatttatt tatggagaca ttcctccaga gatggtgtca      240

gagcccctgg aggacctgga cccctactat atcaataaga aaacttttat agtattgaat      300

aaagggaagg ccatcttccg gttcagtgcc acctctgccc tgtacatttt aactcccttc      360

aatcctctta ggaaaatagc tattaagatt ttggtacatt cattattcag catgctaatt      420

atgtgcacta ttttgacaaa ctgtgtgttt atgacaatga gtaaccctcc tgattggaca      480

aagaatgtag aatacacctt cacaggaata tatacttttg aatcacttat aaaaattatt      540

gcaaggggat tctgtttaga agattttact ttccttcggg atccatggaa ctggctcgat      600

ttcactgtca ttacatttgc gtacgtcaca gagtttgtgg acctgggcaa tgtctcggca      660

ttgagaacat tcagagttct ccgagcattg aagacgattt cagtcattcc aggcctgaaa      720

accattgtgg gagccctgat ccagtctgtg aagaagctct cagatgtaat gatcctgact      780

gtgttctgtc tgagcgtatt tgctctaatt gggctgcagc tgttcatggg caacctgagg      840

aataaatgta tacaatggcc tcccaccaat gcttccttgg aggaacatag tatagaaaag      900

aatataactg tgaattataa tggtacactt ataaatgaaa ctgtctttga gtttgactgg      960

aagtcatata ttcaagattc aagatatcat tatttcctgg agggtttttt agatgcacta     1020

ctatgtggaa atagctctga tgcaggccaa tgtccagagg gatatatgtg tgtgaaagct     1080

ggtagaaatc ccaattatgg ctacacaagc tttgatacct tcagttgggc ttttttgtcc     1140

ttgtttcgac taatgactca ggacttctgg gaaaatcttt atcaactgac attacgtgct     1200

gctgggaaaa cgtacatgat attttttgta ttggtcattt tcttgggctc attctaccta     1260

ataaatttga tcctggctgt ggtggccatg gcctacgagg aacagaatca ggccaccttg     1320

gaagaagcag aacagaaaga ggccgaattt cagcagatga ttgaacagct taaaaagcaa     1380

caggaggcag ctcagcaggc agcaacggca actgcctcag aacattccag agagcccagt     1440

gcagcaggca ggctctcaga cagctcatct gaagcctcta agttgagttc caagagtgct     1500

aaggaaagaa gaaatcggag gaagaaaaga aaacagaaag agcagtctgg tggggaagag     1560

aaagatgagg atgaattcca aaaatctgaa tctgaggaca gcatcaggag gaaaggtttt     1620

cgcttctcca ttgaagggaa ccgattgaca tatgaaaaga ggtactcctc cccacaccag     1680

tctttgttga gcatccgtgg ctccctattt tcaccaaggc gaaatagcag aacaagcctt     1740

ttcagcttta gagggcgagc aaaggatgtg ggatctgaga acgacttcgc agatgatgag     1800

cacagcacct ttgaggataa cgagagccgt agagattcct tgtttgtgcc ccgacgacac     1860

ggagagagac gcaacagcaa cctgagtcag accagtaggt catcccggat gctggcagtg     1920

tttccagcga atgggaagat gcacagcact gtggattgca atggtgtggt ttccttggtt     1980

ggtggacctt cagttcctac atcgcctgtt ggacagcttc tgccagaggt gataatagat     2040

aagccagcta ctgatgacaa tggaacaacc actgaaactg aaatgagaaa gagaaggtca     2100

agttctttcc acgtttccat ggactttcta gaagatcctt cccaaaggca acgagcaatg     2160

agtatagcca gcattctaac aaatacagta gaagaacttg aagaatccag gcagaaatgc     2220

ccaccctgtt ggtataaatt ttccaacata ttcttaatct gggactgttc tccatattgg     2280

ttaaaagtga aacatgttgt caacctggtt gtgatggacc catttgttga cctggccatc     2340

accatctgta ttgtcttaaa tactcttttc atggccatgg agcactatcc aatgacggac     2400

catttcaata atgtgcttac agtaggaaac ttggttttca ctgggatctt tacagcagaa     2460

atgtttctga aaattattgc catggatcct tactattatt tccaagaagg ctggaatatc     2520

tttgacggtt ttattgtgac gcttagcctg gtagaacttg gactcgccaa tgtggaagga     2580

ttatctgttc tccgttcatt tcgattgctg cgagttttca agttggcaaa atcttggcca     2640

acgttaaata tgctaataaa gatcatcggc aattccgtgg gggctctggg aaatttaacc     2700

ctcgtcttgg ccatcatcgt cttcattttt gccgtggtcg gcatgcagct ctttggtaaa     2760

agctacaaag attgtgtctg caagatcgcc agtgattgtc aactcccacg ctggcacatg     2820

aatgacttct tccactcctt cctgattgtg ttccgcgtgc tgtgtgggga gtggatagag     2880

accatgtggg actgtatgga ggttgctggt caagccatgt gccttactgt cttcatgatg     2940

gtcatggtga ttggaaacct agtggtcctg aatctctttc tggccttgct tctgagctca     3000

tttagtgcag acaaccttgc agccactgat gatgataatg aaatgaataa tctccaaatt     3060

gctgtggata ggatgcacaa aggagtagct tatgtgaaaa gaaaaatata tgaatttatt     3120

caacagtcct tcattaggaa acaaaagatt ttagatgaaa ttaaaccact tgatgatcta     3180

aacaacaaga aagacagttg tatgtccaat catacagcag aaattgggaa agatcttgac     3240

tatcttaaag atgtaaatgg aactacaagt ggtataggaa ctggcagcag tgttgaaaaa     3300

tacattattg atgaaagtga ttacatgtca ttcataaaca accccagtct tactgtgact     3360

gtaccaattg ctgtaggaga atctgacttt gaaaatttaa acacggaaga ctttagtagt     3420

gaatcggatc tggaagaaag caaagagaaa ctgaatgaaa gcagtagctc atcagaaggt     3480

agcactgtgg acatcggcgc acctgtagaa gaacagcccg tagtggaacc tgaagaaact     3540

cttgaaccag aagcttgttt cactgaaggc tgtgtacaaa gattcaagtg ttgtcaaatc     3600

aatgtggaag aaggcagagg aaaacaatgg tggaacctga gaaggacgtg tttccgaata     3660

gttgaacata actggtttga gaccttcatt gttttcatga ttctccttag tagtggtgct     3720

ctggcatttg aagatatata tattgatcag cgaaagacga ttaagacgat gttggaatat     3780

gctgacaagg ttttcactta cattttcatt ctggaaatgc ttctaaaatg ggtggcatat     3840

ggctatcaaa catatttcac caatgcctgg tgttggctgg acttcttaat tgttgatgtt     3900

tcattggtca gtttaacagc aaatgccttg ggttactcag aacttggagc catcaaatct     3960

ctcaggacac taagagctct gagacctcta agagccttat ctcgatttga agggatgagg     4020

gtggttgtga atgccctttt aggagcaatt ccatccatca tgaatgtgct tctggtttgt     4080

cttatattct ggctaatttt cagcatcatg ggcgtaaatt tgtttgctgg caaattctac     4140

cactgtatta acaccacaac tggtgacagg tttgacatcg aagacgtgaa taatcatact     4200

gattgcctaa aactaataga aagaaatgag actgctcgat ggaaaaatgt gaaagtaaac     4260

tttgataatg taggatttgg gtatctctct ttgcttcaag ttgccacatt caaaggatgg     4320

atggatataa tgtatgcagc agttgattcc agaaatgtgg aactccagcc taagtatgaa     4380

gaaagtctgt acatgtatct ttactttgtt attttcatca tctttgggtc cttcttcacc     4440

ttgaacctgt ttattggtgt catcatagat aatttcaacc agcagaaaaa gaagtttgga     4500

ggtcaagaca tctttatgac agaagaacag aagaaatact ataatgcaat gaaaaaatta     4560

ggatcgaaaa aaccgcaaaa gcctatacct cgaccaggaa acaaatttca aggaatggtc     4620

tttgacttcg taaccagaca agtttttgac ataagcatca tgattctcat ctgtcttaac     4680

atggtcacaa tgatggtgga aacagatgac cagagtgaat atgtgactac cattttgtca     4740

cgcatcaatc tggtgttcat tgtgctattt actggagagt gtgtactgaa actcatctct     4800

ctacgccatt attattttac cattggatgg aatatttttg attttgtggt tgtcattctc     4860

tccattgtag gtatgtttct tgccgagctg atagaaaagt atttcgtgtc ccctaccctg     4920

ttccgagtga tccgtcttgc taggattggc cgaatcctac gtctgatcaa aggagcaaag     4980

gggatccgca cgctgctctt tgctttgatg atgtcccttc ctgcgttgtt taacatcggc     5040

ctcctactct tcctagtcat gttcatctac gccatctttg ggatgtccaa ctttgcctat     5100

gttaagaggg aagttgggat cgatgacatg ttcaactttg agacctttgg caacagcatg     5160

atctgcctat tccaaattac aacctctgct ggctgggatg gattgctagc acccattctc     5220

aacagtaagc cacccgactg tgaccctaat aaagttaacc ctggaagctc agttaaggga     5280

gactgtggga acccatctgt tggaattttc ttttttgtca gttacatcat catatccttc     5340

ctggttgtgg tgaacatgta catcgcggtc atcctggaga acttcagtgt tgctactgaa     5400

gaaagtgcag agcctctgag tgaggatgac tttgagatgt tctatgaggt ttgggagaag     5460

tttgatcccg atgcaactca gttcatggaa tttgaaaaat tatctcagtt tgcagctgcg     5520

cttgaaccgc ctctcaatct gccacaacca aacaaactcc agctcattgc catggatttg     5580

cccatggtga gtggtgaccg gatccactgt cttgatatct tatttgcttt tacaaagcgg     5640

gttctaggag agagtggaga gatggatgct ctacgaatac agatggaaga gcgattcatg     5700

gcttccaatc cttccaaggt ctcctatcag ccaatcacta ctactttaaa acgaaaacaa     5760

gaggaagtat ctgctgtcat tattcagcgt gcttacagac gccacctttt aaagcgaact     5820

gtaaaacaag cttcctttac gtacaataaa aacaaaatca aaggtggggc taatcttctt     5880

ataaaagaag acatgataat tgacagaata aatgaaaact ctattacaga aaaaactgat     5940

ctgaccatgt ccactgcagc ttgtccacct tcctatgacc gggtgacaaa gccaattgtg     6000

gaaaaacatg agcaagaagg caaagatgaa aaagccaaag ggaaataaat gaaaataaat     6060

aaaaataatt gggtgacaaa ttgtttacag cctgtgaagg tgatgtattt ttatcaacag     6120

gactccttta ggaggtcaat gccaaactga ctgtttttac acaaatctcc ttaaggtcag     6180

tgcctacaat aagacagtga ccccttgtca gcaaactgtg actctgtgta aaggggagat     6240

gaccttgaca ggaggttact gttctcacta ccagctgaca ctgctgaaga taagatgcac     6300

aatggctagt cagactgtag ggaccagttt caaggggtgc aaacctgtga ttttggggtt     6360

gtttaacatg aaacacttta gtgtagtaat tgtatccact gtttgcattt caactgccac     6420

atttgtcaca tttttatgga atctgttagt ggattcatct ttttgttaat ccatgtgttt     6480

attatatgtg actatttttg taaacgaagt ttctgttgag aaataggcta aggacctcta     6540

taacaggtat gccacctggg gggtatggca accacatggc cctcccagct acacaaagtc     6600

gtggtttgca tgagggcatg ctgcacttag agatcatgca tgagaaaaag tcacaagaaa     6660

aacaaattct taaatttcac catatttctg ggaggggtaa ttgggtgata agtggaggtg     6720

ctttgttgat cttgttttgc gaaatccagc ccctagacca agtagattat ttgtgggtag     6780

gccagtaaat cttagcaggt gcaaacttca ttcaaatgtt tggagtcata aatgttatgt     6840

ttctttttgt tgtattaaaa aaaaaacctg aatagtgaat attgcccctc accctccacc     6900

gccagaagac tgaattgacc aaaattactc tttataaatt tctgcttttt cctgcacttt     6960

gtttagccat cttcggctct cagcaaggtt gacactgtat atgttaatga aatgctattt     7020

attatgtaaa tagtcatttt accctgtggt gcacgtttga gcaaacaaat aatgacctaa     7080

gcacagtatt tattgcatca aatatgtacc acaagaaatg tagagtgcaa gctttacaca     7140

ggtaataaaa tgtattctgt accatttata gatagtttgg atgctatcaa tgcatgttta     7200

tattaccatg ctgctgtatc tggtttctct cactgctcag aatctcattt atgagaaacc     7260

atatgtcagt ggtaaagtca aggaaattgt tcaacagatc tcatttattt aagtcattaa     7320

gcaatagttt gcagcacttt aacagctttt tggttatttt tacattttaa gtggataaca     7380

tatggtatat agccagactg tacagacatg tttaaaaaaa cacactgctt aacctattaa     7440

atatgtgttt agaattttat aagcaaatat aaatactgta aaaagtcact ttattttatt     7500

tttcagcatt atgtacataa atatgaagag gaaattatct tcaggttgat atcacaatca     7560

cttttcttac tttctgtcca tagtactttt tcatgaaaga aatttgctaa ataagacatg     7620

aaaacaagac tgggtagttg tagatttctg ctttttaaat tacatttgct aattttagat     7680

tatttcacaa ttttaaggag caaaataggt tcacgattca tatccaaatt atgctttgca     7740

attggaaaag ggtttaaaat tttatttata tttctggtag tacctgcact aactgaattg     7800

aaggtagtgc ttatgttatt tttgttcttt ttttctgact tcggtttatg ttttcatttc     7860

tttggagtaa tgctgctcta gattgttcta aatagaatgt gggcttcata attttttttt     7920

ccacaaaaac agagtagtca acttatatag tcaattacat caggacattt tgtgtttctt     7980

acagaagcaa accataggct cctcttttcc ttaaaactac ttagataaac tgtattcgtg     8040

aactgcatgc tggaaaatgc tactattatg ctaaataatg ctaaccaaca tttaaaatgt     8100

gcaaaactaa taaagattac attttttatt tta                                  8133


<210>  18
<211>  8810
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(8810)
<223>  Homo sapienssodium channel, voltage-gated, type II, alpha subunit
       (SCN2A), transcript variant 2

<400>  18
atgctgtttt ctaacagaca ttgggtacca tcgaatgact gtcagaacag aaagctaagg       60

caaaggaggg aggatgctgt ggtcatcctt tcttgttttt ttcttcttta atgaggatag      120

agcacatgtg agattttact ttctactcca gtaaaaattc tgaagaattg cattggagac      180

tgttatattc aacacatacg tggattctgt gttatgattt acatttttct ttatttcagc      240

actttcttat gcaaggagct aaacagtgat taaaggagca ggatgaaaag atggcacagt      300

cagtgctggt accgccagga cctgacagct tccgcttctt taccagggaa tcccttgctg      360

ctattgaaca acgcattgca gaagagaaag ctaagagacc caaacaggaa cgcaaggatg      420

aggatgatga aaatggccca aagccaaaca gtgacttgga agcaggaaaa tctcttccat      480

ttatttatgg agacattcct ccagagatgg tgtcagtgcc cctggaggat ctggacccct      540

actatatcaa taagaaaacg tttatagtat tgaataaagg gaaagcaatc tctcgattca      600

gtgccacccc tgccctttac attttaactc ccttcaaccc tattagaaaa ttagctatta      660

agattttggt acattcttta ttcaatatgc tcattatgtg cacgattctt accaactgtg      720

tatttatgac catgagtaac cctccagact ggacaaagaa tgtggagtat acctttacag      780

gaatttatac ttttgaatca cttattaaaa tacttgcaag gggcttttgt ttagaagatt      840

tcacattttt acgggatcca tggaattggt tggatttcac agtcattact tttgcatatg      900

tgacagagtt tgtggacctg ggcaatgtct cagcgttgag aacattcaga gttctccgag      960

cattgaaaac aatttcagtc attccaggcc tgaagaccat tgtgggggcc ctgatccagt     1020

cagtgaagaa gctttctgat gtcatgatct tgactgtgtt ctgtctaagc gtgtttgcgc     1080

taataggatt gcagttgttc atgggcaacc tacgaaataa atgtttgcaa tggcctccag     1140

ataattcttc ctttgaaata aatatcactt ccttctttaa caattcattg gatgggaatg     1200

gtactacttt caataggaca gtgagcatat ttaactggga tgaatatatt gaggataaaa     1260

gtcactttta ttttttagag gggcaaaatg atgctctgct ttgtggcaac agctcagatg     1320

caggccagtg tcctgaagga tacatctgtg tgaaggctgg tagaaacccc aactatggct     1380

acacgagctt tgacaccttt agttgggcct ttttgtcctt atttcgtctc atgactcaag     1440

acttctggga aaacctttat caactgacac tacgtgctgc tgggaaaacg tacatgatat     1500

tttttgtgct ggtcattttc ttgggctcat tctatctaat aaatttgatc ttggctgtgg     1560

tggccatggc ctatgaggaa cagaatcagg ccacattgga agaggctgaa cagaaggaag     1620

ctgaatttca gcagatgctc gaacagttga aaaagcaaca agaagaagct caggcggcag     1680

ctgcagccgc atctgctgaa tcaagagact tcagtggtgc tggtgggata ggagtttttt     1740

cagagagttc ttcagtagca tctaagttga gctccaaaag tgaaaaagag ctgaaaaaca     1800

gaagaaagaa aaagaaacag aaagaacagt ctggagaaga agagaaaaat gacagagtcc     1860

gaaaatcgga atctgaagac agcataagaa gaaaaggttt ccgtttttcc ttggaaggaa     1920

gtaggctgac atatgaaaag agattttctt ctccacacca gtccttactg agcatccgtg     1980

gctccctttt ctctccaaga cgcaacagta gggcgagcct tttcagcttc agaggtcgag     2040

caaaggacat tggctctgag aatgactttg ctgatgatga gcacagcacc tttgaggaca     2100

atgacagccg aagagactct ctgttcgtgc cgcacagaca tggagaacgg cgccacagca     2160

atgtcagcca ggccagccgt gcctccaggg tgctccccat cctgcccatg aatgggaaga     2220

tgcatagcgc tgtggactgc aatggtgtgg tctccctggt cgggggccct tctaccctca     2280

catctgctgg gcagctccta ccagagggca caactactga aacagaaata agaaagagac     2340

ggtccagttc ttatcatgtt tccatggatt tattggaaga tcctacatca aggcaaagag     2400

caatgagtat agccagtatt ttgaccaaca ccatggaaga acttgaagaa tccagacaga     2460

aatgcccacc atgctggtat aaatttgcta atatgtgttt gatttgggac tgttgtaaac     2520

catggttaaa ggtgaaacac cttgtcaacc tggttgtaat ggacccattt gttgacctgg     2580

ccatcaccat ctgcattgtc ttaaatacac tcttcatggc tatggagcac tatcccatga     2640

cggagcagtt cagcagtgta ctgtctgttg gaaacctggt cttcacaggg atcttcacag     2700

cagaaatgtt tctcaagata attgccatgg atccatatta ttactttcaa gaaggctgga     2760

atatttttga tggttttatt gtgagcctta gtttaatgga acttggtttg gcaaatgtgg     2820

aaggattgtc agttctccga tcattccggc tgctccgagt tttcaagttg gcaaaatctt     2880

ggccaactct aaatatgcta attaagatca ttggcaattc tgtgggggct ctaggaaacc     2940

tcaccttggt attggccatc atcgtcttca tttttgctgt ggtcggcatg cagctctttg     3000

gtaagagcta caaagaatgt gtctgcaaga tttccaatga ttgtgaactc ccacgctggc     3060

acatgcatga ctttttccac tccttcctga tcgtgttccg cgtgctgtgt ggagagtgga     3120

tagagaccat gtgggactgt atggaggtcg ctggccaaac catgtgcctt actgtcttca     3180

tgatggtcat ggtgattgga aatctagtgg ttctgaacct cttcttggcc ttgcttttga     3240

gttccttcag ttctgacaat cttgctgcca ctgatgatga taacgaaatg aataatctcc     3300

agattgctgt gggaaggatg cagaaaggaa tcgattttgt taaaagaaaa atacgtgaat     3360

ttattcagaa agcctttgtt aggaagcaga aagctttaga tgaaattaaa ccgcttgaag     3420

atctaaataa taaaaaagac agctgtattt ccaaccatac caccatagaa ataggcaaag     3480

acctcaatta tctcaaagac ggaaatggaa ctactagtgg cataggcagc agtgtagaaa     3540

aatatgtcgt ggatgaaagt gattacatgt catttataaa caaccctagc ctcactgtga     3600

cagtaccaat tgctgttgga gaatctgact ttgaaaattt aaatactgaa gaattcagca     3660

gcgagtcaga tatggaggaa agcaaagaga agctaaatgc aactagttca tctgaaggca     3720

gcacggttga tattggagct cccgccgagg gagaacagcc tgaggttgaa cctgaggaat     3780

cccttgaacc tgaagcctgt tttacagaag actgtgtacg gaagttcaag tgttgtcaga     3840

taagcataga agaaggcaaa gggaaactct ggtggaattt gaggaaaaca tgctataaga     3900

tagtggagca caattggttc gaaaccttca ttgtcttcat gattctgctg agcagtgggg     3960

ctctggcctt tgaagatata tacattgagc agcgaaaaac cattaagacc atgttagaat     4020

atgctgacaa ggttttcact tacatattca ttctggaaat gctgctaaag tgggttgcat     4080

atggttttca agtgtatttt accaatgcct ggtgctggct agacttcctg attgttgatg     4140

tctcactggt tagcttaact gcaaatgcct tgggttactc agaacttggt gccatcaaat     4200

ccctcagaac actaagagct ctgaggccac tgagagcttt gtcccggttt gaaggaatga     4260

gggttgttgt aaatgctctt ttaggagcca ttccatctat catgaatgta cttctggttt     4320

gtctgatctt ttggctaata ttcagtatca tgggagtgaa tctctttgct ggcaagtttt     4380

accattgtat taattacacc actggagaga tgtttgatgt aagcgtggtc aacaactaca     4440

gtgagtgcaa agctctcatt gagagcaatc aaactgccag gtggaaaaat gtgaaagtaa     4500

actttgataa cgtaggactt ggatatctgt ctctacttca agtagccacg tttaagggat     4560

ggatggatat tatgtatgca gctgttgatt cacgaaatgt agaattacaa cccaagtatg     4620

aagacaacct gtacatgtat ctttattttg tcatctttat tatttttggt tcattcttta     4680

ccttgaatct tttcattggt gtcatcatag ataacttcaa ccaacagaaa aagaagtttg     4740

gaggtcaaga catttttatg acagaagaac agaagaaata ctacaatgca atgaaaaaac     4800

tgggttcaaa gaaaccacaa aaacccatac ctcgacctgc taacaaattc caaggaatgg     4860

tctttgattt tgtaaccaaa caagtctttg atatcagcat catgatcctc atctgcctta     4920

acatggtcac catgatggtg gaaaccgatg accagagtca agaaatgaca aacattctgt     4980

actggattaa tctggtgttt attgttctgt tcactggaga atgtgtgctg aaactgatct     5040

ctcttcgtta ctactatttc actattggat ggaatatttt tgattttgtg gtggtcattc     5100

tctccattgt aggaatgttt ctggctgaac tgatagaaaa gtattttgtg tcccctaccc     5160

tgttccgagt gatccgtctt gccaggattg gccgaatcct acgtctgatc aaaggagcaa     5220

aggggatccg cacgctgctc tttgctttga tgatgtccct tcctgcgttg tttaacatcg     5280

gcctccttct tttcctggtc atgttcatct acgccatctt tgggatgtcc aattttgcct     5340

atgttaagag ggaagttggg atcgatgaca tgttcaactt tgagaccttt ggcaacagca     5400

tgatctgcct gttccaaatt acaacctctg ctggctggga tggattgcta gcacctattc     5460

ttaatagtgg acctccagac tgtgaccctg acaaagatca ccctggaagc tcagttaaag     5520

gagactgtgg gaacccatct gttgggattt tcttttttgt cagttacatc atcatatcct     5580

tcctggttgt ggtgaacatg tacatcgcgg tcatcctgga gaacttcagt gttgctactg     5640

aagaaagtgc agagcctctg agtgaggatg actttgagat gttctatgag gtttgggaga     5700

agtttgatcc cgatgcgacc cagtttatag agtttgccaa actttctgat tttgcagatg     5760

ccctggatcc tcctcttctc atagcaaaac ccaacaaagt ccagctcatt gccatggatc     5820

tgcccatggt gagtggtgac cggatccact gtcttgacat cttatttgct tttacaaagc     5880

gtgttttggg tgagagtgga gagatggatg cccttcgaat acagatggaa gagcgattca     5940

tggcatcaaa cccctccaaa gtctcttatg agcccattac gaccacgttg aaacgcaaac     6000

aagaggaggt gtctgctatt attatccaga gggcttacag acgctacctc ttgaagcaaa     6060

aagttaaaaa ggtatcaagt atatacaaga aagacaaagg caaagaatgt gatggaacac     6120

ccatcaaaga agatactctc attgataaac tgaatgagaa ttcaactcca gagaaaaccg     6180

atatgacgcc ttccaccacg tctccaccct cgtatgatag tgtgaccaaa ccagaaaaag     6240

aaaaatttga aaaagacaaa tcagaaaagg aagacaaagg gaaagatatc agggaaagta     6300

aaaagtaaaa agaaaccaag aattttccat tttgtgatca attgtttaca gcccgtgatg     6360

gtgatgtgtt tgtgtcaaca ggactcccac aggaggtcta tgccaaactg actgttttta     6420

caaatgtata cttaaggtca gtgcctataa caagacagag acctctggtc agcaaactgg     6480

aactcagtaa actggagaaa tagtatcgat gggaggtttc tattttcaca accagctgac     6540

actgctgaag agcagaggcg taatggctac tcagacgata ggaaccaatt taaagggggg     6600

agggaagtta aatttttatg taaattcaac atgtgacact tgataatagt aattgtcacc     6660

agtgtttatg ttttaactgc cacacctgcc atatttttac aaaacgtgtg ctgtgaattt     6720

atcacttttc tttttaattc acaggttgtt tactattata tgtgactatt tttgtaaatg     6780

ggtttgtgtt tggggagagg gattaaaggg agggaattct acatttctct attgtattgt     6840

ataactggat atattttaaa tggaggcatg ctgcaattct cattcacaca taaaaaaatc     6900

acatcacaaa agggaagagt ttacttcttg tttcaggatg tttttagatt tttgaggtgc     6960

ttaaatagct attcgtattt ttaaggtgtc tcatccagaa aaaatttaat gtgcctgtaa     7020

atgttccata gaatcacaag cattaaagag ttgttttatt tttacataac ccattaaatg     7080

tacatgtata tatgtatata tgtatatgtg cgtgtatata catatatatg tatacacaca     7140

tgcacacaca gagatataca cataccatta cattgtcatt cacagtccca gcagcatgac     7200

tatcacattt ttgataagtg tcctttggca taaaataaaa atatcctatc agtcctttct     7260

aagaagcctg aattgaccaa aaaacatccc caccaccact ttataaagtt gattctgctt     7320

tatcctgcag tattgtttag ccatcttctg ctcttggtaa ggttgacata gtatatgtca     7380

atttaaaaaa taaaagtctg ctttgtaaat agtaatttta cccagtggtg catgtttgag     7440

caaacaaaaa tgatgattta agcacactac ttattgcatc aaatatgtac cacagtaagt     7500

atagtttgca agctttcaac aggtaatatg atgtaattgg ttccattata gtttgaagct     7560

gtcactgctg catgtttatc ttgcctatgc tgctgtatct tattccttcc actgttcaga     7620

agtctaatat gggaagccat atatcagtgg taaagtgaag caaattgttc taccaagacc     7680

tcattcttca tgtcattaag caataggttg cagcaaacaa ggaagagctt cttgcttttt     7740

attcttccaa ccttaattga acactcaatg atgaaaagcc cgactgtaca aacatgttgc     7800

aagctgctta aatctgttta aaatatatgg ttagagtttt ctaagaaaat ataaatactg     7860

taaaaagttc attttatttt atttttcagc cttttgtacg taaaatgaga aattaaaagt     7920

atcttcaggt ggatgtcaca gtcactattg ttagtttctg ttcctagcac ttttaaattg     7980

aagcacttca caaaataaga agcaaggact aggatgcagt gtaggtttct gcttttttat     8040

tagtactgta aacttgcaca catttcaatg tgaaacaaat ctcaaactga gttcaatgtt     8100

tatttgcttt caatagtaat gccttatcat tgaaagaggc ttaaagaaaa aaaaaatcag     8160

ctgatactct tggcattgct tgaatccaat gtttccacct agtcttttta ttcagtaatc     8220

atcagtcttt tccaatgttt gtttacacag atagatctta ttgacccata tggcactaga     8280

actgtatcag atataatatg ggatcccagc tttttttcct ctcccacaaa accaggtagt     8340

gaagttatat taccagttac agcaaaatac tttgtgtttc acaagcaaca ataaatgtag     8400

attctttata ctgaagctat tgacttgtag tgtgttggtg aaatgcatgc aggaaaatgc     8460

tgttaccata aagaacggta aaccacatta caatcaagcc aaaagaataa aggtttcgct     8520

tttgtttttg tatttaattg ttgtctttgt ttctatcttt gaaatgccat ttaaaggtag     8580

atttctatca tgtaaaaata atctatctga aaaacaaatg taaagaacac acattaatta     8640

ctataattca tctttcaatt ttttcatgga atggaagtta attaagaaga gtgtattgga     8700

taactacttt aatattggcc aaaaagctag atatggcatc aggtagacta gtggaaagtt     8760

acaaaaatta ataaaaaatt gactaacatt ttaaaaaaaa aaaaaaaaaa                8810


<210>  19
<211>  8994
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(8994)
<223>  Homo sapienssodium channel, voltage-gated, type III, alpha 
       subunit (SCN3A), transcript variant 2

<400>  19
accatagagt gaatctcaga acaggaagcg gaggcataag cagagaggat tctggaaagg       60

tctctttgtt ttcttatcca cagagaaaga aagaaaaaaa attgtaacta atttgtaaac      120

ctctgtggtc aaaaaaaaaa aaaaaaaaaa aagctgaaca gctgcagagg aagacacgtt      180

ataccctaac catcttggat gctgggcttt gttatgctgt aattcataag gctctgtttt      240

atcagagatt atggagcaag aaaactgaag ccaagccaca tcaaggtttg acagggatga      300

gatacctgtc aaggattcat agtagagtgg cttactggga aaggagcaaa gaatctcttc      360

tagggatatt gtaagaataa atgagataat tcacagaagg gacctggagc ttttccggaa      420

aaaggtgctg tgactatcta aggtaattcg tatgcaagaa gctacacgta attaaatgtg      480

caggatgaaa agatggcaca ggcactgttg gtacccccag gacctgaaag cttccgcctt      540

tttactagag aatctcttgc tgctatcgaa aaacgtgctg cagaagagaa agccaagaag      600

cccaaaaagg aacaagataa tgatgatgag aacaaaccaa agccaaatag tgacttggaa      660

gctggaaaga accttccatt tatttatgga gacattcctc cagagatggt gtcagagccc      720

ctggaggacc tggatcccta ctatatcaat aagaaaactt ttatagtaat gaataaagga      780

aaggcaattt tccgattcag tgccacctct gccttgtata ttttaactcc actaaaccct      840

gttaggaaaa ttgctatcaa gattttggta cattctttat tcagcatgct tatcatgtgc      900

actattttga ccaactgtgt atttatgacc ttgagcaacc ctcctgactg gacaaagaat      960

gtagagtaca cattcactgg aatctatacc tttgagtcac ttataaaaat cttggcaaga     1020

gggttttgct tagaagattt tacgtttctt cgtgatccat ggaactggct ggatttcagt     1080

gtcattgtga tggcatatgt gacagagttt gtggacctgg gcaatgtctc agcgttgaga     1140

acattcagag ttctccgagc actgaaaaca atttcagtca ttccaggttt aaagaccatt     1200

gtgggggccc tgatccagtc ggtaaagaag ctttctgatg tgatgatcct gactgtgttc     1260

tgtctgagcg tgtttgctct cattgggctg cagctgttca tgggcaatct gaggaataaa     1320

tgtttgcagt ggcccccaag cgattctgct tttgaaacca acaccacttc ctactttaat     1380

ggcacaatgg attcaaatgg gacatttgtt aatgtaacaa tgagcacatt taactggaag     1440

gattacattg gagatgacag tcacttttat gttttggatg ggcaaaaaga ccctttactc     1500

tgtggaaatg gctcagatgc aggccagtgt ccagaaggat acatctgtgt gaaggctggt     1560

cgaaacccca actatggcta cacaagcttt gacaccttta gctgggcttt cctgtctcta     1620

tttcgactca tgactcaaga ctactgggaa aatctttacc agttgacatt acgtgctgct     1680

gggaaaacat acatgatatt ttttgtcctg gtcattttct tgggctcatt ttatttggtg     1740

aatttgatcc tggctgtggt ggccatggcc tatgaggagc agaatcaggc caccttggaa     1800

gaagcagaac aaaaagaggc cgaatttcag cagatgctcg aacagcttaa aaagcaacag     1860

gaagaagctc aggcagttgc ggcagcatca gctgcttcaa gagatttcag tggaataggt     1920

gggttaggag agctgttgga aagttcttca gaagcatcaa agttgagttc caaaagtgct     1980

aaagaatgga ggaaccgaag gaagaaaaga agacagagag agcaccttga aggaaacaac     2040

aaaggagaga gagacagctt tcccaaatcc gaatctgaag acagcgtcaa aagaagcagc     2100

ttccttttct ccatggatgg aaacagactg accagtgaca aaaaattctg ctcccctcat     2160

cagtctctct tgagtatccg tggctccctg ttttccccaa gacgcaatag caaaacaagc     2220

attttcagtt tcagaggtcg ggcaaaggat gttggatctg aaaatgactt tgctgatgat     2280

gaacacagca catttgaaga cagcgaaagc aggagagact cactgtttgt gccgcacaga     2340

catggagagc gacgcaacag taacggcacc accacagaaa cggaagtcag aaagagaagg     2400

ttaagctctt accagatttc aatggagatg ctggaggatt cctctggaag gcaaagagcc     2460

gtgagcatag ccagcattct gaccaacaca atggaagaac ttgaagaatc tagacagaaa     2520

tgtccgccat gctggtatag atttgccaat gtgttcttga tctgggactg ctgtgatgca     2580

tggttaaaag taaaacatct tgtgaattta attgttatgg atccatttgt tgatcttgcc     2640

atcactattt gcattgtctt aaataccctc tttatggcca tggagcacta ccccatgact     2700

gagcaattca gtagtgtgtt gactgtagga aacctggtct ttactgggat tttcacagca     2760

gaaatggttc tcaagatcat tgccatggat ccttattact atttccaaga aggctggaat     2820

atctttgatg gaattattgt cagcctcagt ttaatggagc ttggtctgtc aaatgtggag     2880

ggattgtctg tactgcgatc attcagactg cttagagttt tcaagttggc aaaatcctgg     2940

cccacactaa atatgctaat taagatcatt ggcaattctg tgggggctct aggaaacctc     3000

accttggtgt tggccatcat cgtcttcatt tttgctgtgg tcggcatgca gctctttggt     3060

aagagctaca aagaatgtgt ctgcaagatc aatgatgact gtacgctccc acggtggcac     3120

atgaacgact tcttccactc cttcctgatt gtgttccgcg tgctgtgtgg agagtggata     3180

gagaccatgt gggactgtat ggaggtcgct ggccaaacca tgtgccttat tgttttcatg     3240

ttggtcatgg tcattggaaa ccttgtggtt ctgaacctct ttctggcctt attgttgagt     3300

tcatttagct cagacaacct tgctgctact gatgatgaca atgaaatgaa taatctgcag     3360

attgcagtag gaagaatgca aaagggaatt gattatgtga aaaataagat gcgggagtgt     3420

ttccaaaaag ccttttttag aaagccaaaa gttatagaaa tccatgaagg caataagata     3480

gacagctgca tgtccaataa tactggaatt gaaataagca aagagcttaa ttatcttaga     3540

gatgggaatg gaaccaccag tggtgtaggt actggaagca gtgttgaaaa atacgtaatc     3600

gatgaaaatg attatatgtc attcataaac aaccccagcc tcaccgtcac agtgccaatt     3660

gctgttggag agtctgactt tgaaaactta aatactgaag agttcagcag tgagtcagaa     3720

ctagaagaaa gcaaagagaa attaaatgca accagctcat ctgaaggaag cacagttgat     3780

gttgttctac cccgagaagg tgaacaagct gaaactgaac ccgaagaaga ccttaaaccg     3840

gaagcttgtt ttactgaagg atgtattaaa aagtttccat tctgtcaagt aagtacagaa     3900

gaaggcaaag ggaagatctg gtggaatctt cgaaaaacct gctacagtat tgttgagcac     3960

aactggtttg agactttcat tgtgttcatg atccttctca gtagtggtgc attggccttt     4020

gaagatatat acattgaaca gcgaaagact atcaaaacca tgctagaata tgctgacaaa     4080

gtctttacct atatattcat tctggaaatg cttctcaaat gggttgctta tggatttcaa     4140

acatatttca ctaatgcctg gtgctggcta gatttcttga tcgttgatgt ttctttggtt     4200

agcctggtag ccaatgctct tggctactca gaactcggtg ccatcaaatc attacggaca     4260

ttaagagctt taagacctct aagagcctta tcccggtttg aaggcatgag ggtggttgtg     4320

aatgctcttg ttggagcaat tccctctatc atgaatgtgc tgttggtctg tctcatcttc     4380

tggttgatct ttagcatcat gggtgtgaat ttgtttgctg gcaagttcta ccactgtgtt     4440

aacatgacaa cgggtaacat gtttgacatt agtgatgtta acaatttgag tgactgtcag     4500

gctcttggca agcaagctcg gtggaaaaac gtgaaagtaa actttgataa tgttggcgct     4560

ggctatcttg cactgcttca agtggccaca tttaaaggct ggatggatat tatgtatgca     4620

gctgttgatt cacgagatgt taaacttcag cctgtatatg aagaaaatct gtacatgtat     4680

ttatactttg tcatctttat catctttggg tcattcttca ctctgaatct attcattggt     4740

gtcatcatag ataacttcaa ccagcagaaa aagaagtttg gaggtcaaga catctttatg     4800

acagaggaac agaaaaaata ttacaatgca atgaagaaac ttggatccaa gaaacctcag     4860

aaacccatac ctcgcccagc aaacaaattc caaggaatgg tctttgattt tgtaaccaga     4920

caagtctttg atatcagcat catgatcctc atctgcctca acatggtcac catgatggtg     4980

gaaacggatg accagggcaa atacatgacc ctagttttgt cccggatcaa cctagtgttc     5040

attgttctgt tcactggaga atttgtgctg aagctcgtct ccctcagaca ctactacttc     5100

actataggct ggaacatctt tgactttgtg gtggtgattc tctccattgt aggtatgttt     5160

ctggctgaga tgatagaaaa gtattttgtg tcccctacct tgttccgagt gatccgtctt     5220

gccaggattg gccgaatcct acgtctgatc aaaggagcaa aggggatccg cacgctgctc     5280

tttgctttga tgatgtccct tcctgcgttg tttaacatcg gcctcctgct cttcctggtc     5340

atgtttatct atgccatctt tgggatgtcc aactttgcct atgttaaaaa ggaagctgga     5400

attgatgaca tgttcaactt tgagaccttt ggcaacagca tgatctgctt gttccaaatt     5460

acaacctctg ctggctggga tggattgcta gcacctattc ttaatagtgc accacccgac     5520

tgtgaccctg acacaattca ccctggcagc tcagttaagg gagactgtgg gaacccatct     5580

gttgggattt tcttttttgt cagttacatc atcatatcct tcctggttgt ggtgaacatg     5640

tacatcgcgg tcatcctgga gaacttcagt gttgctactg aagaaagtgc agagcccctg     5700

agtgaggatg actttgagat gttctatgag gtttgggaaa agtttgatcc cgatgcgacc     5760

cagtttatag agttctctaa actctctgat tttgcagctg ccctggatcc tcctcttctc     5820

atagcaaaac ccaacaaagt ccagcttatt gccatggatc tgcccatggt cagtggtgac     5880

cggatccact gtcttgatat tttatttgcc tttacaaagc gtgttttggg tgagagtgga     5940

gagatggatg cccttcgaat acagatggaa gacaggttta tggcatcaaa cccctccaaa     6000

gtctcttatg agcctattac aaccactttg aaacgtaaac aagaggaggt gtctgccgct     6060

atcattcagc gtaatttcag atgttatctt ttaaagcaaa ggttaaaaaa tatatcaagt     6120

aactataaca aagaggcaat taaagggagg attgacttac ctataaaaca agacatgatt     6180

attgacaaac taaatgggaa ctccactcca gaaaaaacag atgggagttc ctctaccacc     6240

tctcctcctt cctatgatag tgtaacaaaa ccagacaagg aaaagtttga gaaagacaaa     6300

ccagaaaaag aaagcaaagg aaaagaggtc agagaaaatc aaaagtaaaa agaaacaaag     6360

aattatcttt gtgatcaatt gtttacagcc tatgaaggta aagtatatgt gtcaactgga     6420

cttcaagagg aggtccatgc caaactgact gttttaacaa atactcatag tcagtgccta     6480

tacaagacag tgaagtgacc tctctgtcac tgcaactctg tgaagcaggg tatcaacatt     6540

gacaagaggt tgctgttttt attaccagct gacactgctg aggagaaacc caatggctac     6600

ctagactata gggatagttg tgcaaagtga acattgtaac tacaccaaac acctttagta     6660

cagtccttgc atccattcta tttttaactt ccatatctgc catattttta caaaatttgt     6720

tctagtgcat ttccatggtc cccaattcat agtttattca taatgctatg tcactatttt     6780

tgtaaatgag gtttacgttg aagaaacagt atacaagaac cctgtctctc aaatgatcag     6840

acaaaggtgt tttgccagag agataaaatt tttgctcaaa accagaaaaa gaattgtaat     6900

ggctacagtt tcagttactt ccattttcta gatggcttta attttgaaag tattttagtc     6960

tgttatgttt gtttctatct gaacagttat gtgcctgtaa agtctcctct aatatttaaa     7020

ggattatttt tatgcaaagt attctgtttc agcaagtgca aattttattc taagtttcag     7080

agctctatat ttaatttagg tcaaatgctt tccaaaaagt aatctaataa atccattcta     7140

gaaaaatata tctaaagtat tgctttagaa tagttgttcc actttctgct gcagtattgc     7200

tttgccatct tctgctctca gcaaagctga tagtctatgt caattaaata ccctatgtta     7260

tgtaaatagt tattttatcc tgtggtgcat gtttgggcaa atatatatat agcctgataa     7320

acaacttcta ttaaatcaaa tatgtaccac agtgtatgtg tcttttgcaa gcttccaaca     7380

gggatgtatc ctgtatcatt cattaaacat agtttaaagg ctatcactaa tgcatgttaa     7440

tattgcctat gctgctctat tttactcaat ccattcttca caagtcttgg ttaaagaatg     7500

tcacatattg gtgatagaat gaattcaacc tgctctgtcc attatgtcaa gcagaataat     7560

ttgaagctat ttacaaacac ctttactttt gcacttttaa ttcaacatga gtatcatatg     7620

gtatctctct agatttcaag gaaacacact ggatactgcc tactgacaaa acctattctt     7680

catattttgc taaaaatatg tctaaaactt gtttaaatat aaataatgta aaaatataat     7740

caactttatt tgtcagcatt ttgtacataa gaaaattatt ttcaggttga tgacatcaca     7800

atttatttta ctttatgctt ttgcttttga tttttaatca caattccaaa cttttgaatc     7860

cataagattt ttcaatggat aatttcctaa aataaaagtt agataatggg ttttatggat     7920

ttctttgtta taatatattt tctaccattc caataggaga tacattggtc aaacactcaa     7980

acctagatca ttttctacca actatggttg cctcaatata accttttatt catagatgtt     8040

tttttttatt caacttttgt agtatttacg tatgcagact agtcttattt ttttaattcc     8100

tgctgcacta aagctattac aaatataaca tggactttgt tctttttagc catgaacaaa     8160

gtggcaaagt tgtgcaatta cctaacatga tataaatttt tgttttttgc acaaaccaaa     8220

agtttaatgt taattctttt tacaaaacta tttactgtag tgtattgaag aactgcatgc     8280

agggaattgc tattgctaaa aagaatggtg agctacgtca ttattgagcc aaaagaataa     8340

atttcatttt ttattgcatt tcacttattg gcctctgggg ttttttgttt ttgttttttg     8400

ctgttggcag tttaaaatat atataattaa taaaacctgt gcttgatctg acatttgtat     8460

acataaaagt ttacatgaat tttacaacaa actagtgcat gattcaccaa gcagtactac     8520

agaacaaagg caaattaaaa gcagctttgt gaacttttat gtgtgcaaag gatcaagttc     8580

acatgttcca actttcaggt ttgataataa tagtagtaac cacctacaat agctttcaat     8640

ttcaattaac tcccttggct ataagcatct aaactcatct tctttcaata taattgatgc     8700

tatctcctaa ttacttggtg gctaataaat gttacattct ttgttactta aatgcattat     8760

ataaactcct atgtatacat aaggtattaa tgatatagtt attgagaatt tatattaact     8820

tttttttcaa gaacccttgg atttatgtga ggtcaaaacc aaactcttat tctcagtgga     8880

aaactccagt tgtaatgcat atttttaaag acaatttgga tctaaatatg tatttcataa     8940

ttctcccata ataaattata taaggtggct aattggaaaa aaaaaaaaaa aaaa           8994


<210>  20
<211>  9771
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(9771)
<223>  Homo sapienssodium channel, voltage-gated, type IX, alpha subunit
       (SCN9A)

<400>  20
cggggctgct acctccacgg gcgcgccctg gcaggagggg cgcagtctgc ttgcaggcgg       60

tcgccagcgc tccagcggcg gctgtcggct ttccaattcc gccagctcgg ctgaggctgg      120

gctagcctgg gtgccagtgg ctgctagcgg caggcgtccc ctgagcaaca ggagcccaga      180

gaaaaagaag cagccctgag agagcgccgg ggaaggagag gcccgcgccc tctcctggag      240

ccagattctg caggtgcact gggtggggat gatcggcggg ctaggttgca agcctcttat      300

gtgaggagct gaagaggaat taaaatatac aggatgaaaa gatggcaatg ttgcctcccc      360

caggacctca gagctttgtc catttcacaa aacagtctct tgccctcatt gaacaacgca      420

ttgctgaaag aaaatcaaag gaacccaaag aagaaaagaa agatgatgat gaagaagccc      480

caaagccaag cagtgacttg gaagctggca aacagctgcc cttcatctat ggggacattc      540

ctcccggcat ggtgtcagag cccctggagg acttggaccc ctactatgca gacaaaaaga      600

ctttcatagt attgaacaaa gggaaaacaa tcttccgttt caatgccaca cctgctttat      660

atatgctttc tcctttcagt cctctaagaa gaatatctat taagatttta gtacactcct      720

tattcagcat gctcatcatg tgcactattc tgacaaactg catatttatg accatgaata      780

acccaccgga ctggaccaaa aatgtcgagt acacttttac tggaatatat acttttgaat      840

cacttgtaaa aatccttgca agaggcttct gtgtaggaga attcactttt cttcgtgacc      900

cgtggaactg gctggatttt gtcgtcattg tttttgcgta tttaacagaa tttgtaaacc      960

taggcaatgt ttcagctctt cgaactttca gagtattgag agctttgaaa actatttctg     1020

taatcccagg cctgaagaca attgtagggg ctttgatcca gtcagtgaag aagctttctg     1080

atgtcatgat cctgactgtg ttctgtctga gtgtgtttgc actaattgga ctacagctgt     1140

tcatgggaaa cctgaagcat aaatgttttc gaaattcact tgaaaataat gaaacattag     1200

aaagcataat gaatacccta gagagtgaag aagactttag aaaatatttt tattacttgg     1260

aaggatccaa agatgctctc ctttgtggtt tcagcacaga ttcaggtcag tgtccagagg     1320

ggtacacctg tgtgaaaatt ggcagaaacc ctgattatgg ctacacgagc tttgacactt     1380

tcagctgggc cttcttagcc ttgtttaggc taatgaccca agattactgg gaaaaccttt     1440

accaacagac gctgcgtgct gctggcaaaa cctacatgat cttctttgtc gtagtgattt     1500

tcctgggctc cttttatcta ataaacttga tcctggctgt ggttgccatg gcatatgaag     1560

aacagaacca ggcaaacatt gaagaagcta aacagaaaga attagaattt caacagatgt     1620

tagaccgtct taaaaaagag caagaagaag ctgaggcaat tgcagcggca gcggctgaat     1680

atacaagtat taggagaagc agaattatgg gcctctcaga gagttcttct gaaacatcca     1740

aactgagctc taaaagtgct aaagaaagaa gaaacagaag aaagaaaaag aatcaaaaga     1800

agctctccag tggagaggaa aagggagatg ctgagaaatt gtcgaaatca gaatcagagg     1860

acagcatcag aagaaaaagt ttccaccttg gtgtcgaagg gcataggcga gcacatgaaa     1920

agaggttgtc tacccccaat cagtcaccac tcagcattcg tggctccttg ttttctgcaa     1980

ggcgaagcag cagaacaagt ctttttagtt tcaaaggcag aggaagagat ataggatctg     2040

agactgaatt tgccgatgat gagcacagca tttttggaga caatgagagc agaaggggct     2100

cactgtttgt gccccacaga ccccaggagc gacgcagcag taacatcagc caagccagta     2160

ggtccccacc aatgctgccg gtgaacggga aaatgcacag tgctgtggac tgcaacggtg     2220

tggtctccct ggttgatgga cgctcagccc tcatgctccc caatggacag cttctgccag     2280

agggcacgac caatcaaata cacaagaaaa ggcgttgtag ttcctatctc ctttcagagg     2340

atatgctgaa tgatcccaac ctcagacaga gagcaatgag tagagcaagc atattaacaa     2400

acactgtgga agaacttgaa gagtccagac aaaaatgtcc accttggtgg tacagatttg     2460

cacacaaatt cttgatctgg aattgctctc catattggat aaaattcaaa aagtgtatct     2520

attttattgt aatggatcct tttgtagatc ttgcaattac catttgcata gttttaaaca     2580

cattatttat ggctatggaa caccacccaa tgactgagga attcaaaaat gtacttgcta     2640

taggaaattt ggtctttact ggaatctttg cagctgaaat ggtattaaaa ctgattgcca     2700

tggatccata tgagtatttc caagtaggct ggaatatttt tgacagcctt attgtgactt     2760

taagtttagt ggagctcttt ctagcagatg tggaaggatt gtcagttctg cgatcattca     2820

gactgctccg agtcttcaag ttggcaaaat cctggccaac attgaacatg ctgattaaga     2880

tcattggtaa ctcagtaggg gctctaggta acctcacctt agtgttggcc atcatcgtct     2940

tcatttttgc tgtggtcggc atgcagctct ttggtaagag ctacaaagaa tgtgtctgca     3000

agatcaatga tgactgtacg ctcccacggt ggcacatgaa cgacttcttc cactccttcc     3060

tgattgtgtt ccgcgtgctg tgtggagagt ggatagagac catgtgggac tgtatggagg     3120

tcgctggtca agctatgtgc cttattgttt acatgatggt catggtcatt ggaaacctgg     3180

tggtcctaaa cctatttctg gccttattat tgagctcatt tagttcagac aatcttacag     3240

caattgaaga agaccctgat gcaaacaacc tccagattgc agtgactaga attaaaaagg     3300

gaataaatta tgtgaaacaa accttacgtg aatttattct aaaagcattt tccaaaaagc     3360

caaagatttc cagggagata agacaagcag aagatctgaa tactaagaag gaaaactata     3420

tttctaacca tacacttgct gaaatgagca aaggtcacaa tttcctcaag gaaaaagata     3480

aaatcagtgg ttttggaagc agcgtggaca aacacttgat ggaagacagt gatggtcaat     3540

catttattca caatcccagc ctcacagtga cagtgccaat tgcacctggg gaatccgatt     3600

tggaaaatat gaatgctgag gaacttagca gtgattcgga tagtgaatac agcaaagtga     3660

gattaaaccg gtcaagctcc tcagagtgca gcacagttga taaccctttg cctggagaag     3720

gagaagaagc agaggctgaa cctatgaatt ccgatgagcc agaggcctgt ttcacagatg     3780

gttgtgtacg gaggttctca tgctgccaag ttaacataga gtcagggaaa ggaaaaatct     3840

ggtggaacat caggaaaacc tgctacaaga ttgttgaaca cagttggttt gaaagcttca     3900

ttgtcctcat gatcctgctc agcagtggtg ccctggcttt tgaagatatt tatattgaaa     3960

ggaaaaagac cattaagatt atcctggagt atgcagacaa gatcttcact tacatcttca     4020

ttctggaaat gcttctaaaa tggatagcat atggttataa aacatatttc accaatgcct     4080

ggtgttggct ggatttccta attgttgatg tttctttggt tactttagtg gcaaacactc     4140

ttggctactc agatcttggc cccattaaat cccttcggac actgagagct ttaagacctc     4200

taagagcctt atctagattt gaaggaatga gggtcgttgt gaatgcactc ataggagcaa     4260

ttccttccat catgaatgtg ctacttgtgt gtcttatatt ctggctgata ttcagcatca     4320

tgggagtaaa tttgtttgct ggcaagttct atgagtgtat taacaccaca gatgggtcac     4380

ggtttcctgc aagtcaagtt ccaaatcgtt ccgaatgttt tgcccttatg aatgttagtc     4440

aaaatgtgcg atggaaaaac ctgaaagtga actttgataa tgtcggactt ggttacctat     4500

ctctgcttca agttgcaact tttaagggat ggacgattat tatgtatgca gcagtggatt     4560

ctgttaatgt agacaagcag cccaaatatg aatatagcct ctacatgtat atttattttg     4620

tcgtctttat catctttggg tcattcttca ctttgaactt gttcattggt gtcatcatag     4680

ataatttcaa ccaacagaaa aagaagcttg gaggtcaaga catctttatg acagaagaac     4740

agaagaaata ctataatgca atgaaaaagc tggggtccaa gaagccacaa aagccaattc     4800

ctcgaccagg gaacaaaatc caaggatgta tatttgacct agtgacaaat caagcctttg     4860

atattagtat catggttctt atctgtctca acatggtaac catgatggta gaaaaggagg     4920

gtcaaagtca acatatgact gaagttttat attggataaa tgtggttttt ataatccttt     4980

tcactggaga atgtgtgcta aaactgatct ccctcagaca ctactacttc actgtaggat     5040

ggaatatttt tgattttgtg gttgtgatta tctccattgt aggtatgttt ctagctgatt     5100

tgattgaaac gtattttgtg tcccctaccc tgttccgagt gatccgtctt gccaggattg     5160

gccgaatcct acgtctagtc aaaggagcaa aggggatccg cacgctgctc tttgctttga     5220

tgatgtccct tcctgcgttg tttaacatcg gcctcctgct cttcctggtc atgttcatct     5280

acgccatctt tggaatgtcc aactttgcct atgttaaaaa ggaagatgga attaatgaca     5340

tgttcaattt tgagaccttt ggcaacagta tgatttgcct gttccaaatt acaacctctg     5400

ctggctggga tggattgcta gcacctattc ttaacagtaa gccacccgac tgtgacccaa     5460

aaaaagttca tcctggaagt tcagttgaag gagactgtgg taacccatct gttggaatat     5520

tctactttgt tagttatatc atcatatcct tcctggttgt ggtgaacatg tacattgcag     5580

tcatactgga gaattttagt gttgccactg aagaaagtac tgaacctctg agtgaggatg     5640

actttgagat gttctatgag gtttgggaga agtttgatcc cgatgcgacc cagtttatag     5700

agttctctaa actctctgat tttgcagctg ccctggatcc tcctcttctc atagcaaaac     5760

ccaacaaagt ccagctcatt gccatggatc tgcccatggt tagtggtgac cggatccatt     5820

gtcttgacat cttatttgct tttacaaagc gtgttttggg tgagagtggg gagatggatt     5880

ctcttcgttc acagatggaa gaaaggttca tgtctgcaaa tccttccaaa gtgtcctatg     5940

aacccatcac aaccacacta aaacggaaac aagaggatgt gtctgctact gtcattcagc     6000

gtgcttatag acgttaccgc ttaaggcaaa atgtcaaaaa tatatcaagt atatacataa     6060

aagatggaga cagagatgat gatttactca ataaaaaaga tatggctttt gataatgtta     6120

atgagaactc aagtccagaa aaaacagatg ccacttcatc caccacctct ccaccttcat     6180

atgatagtgt aacaaagcca gacaaagaga aatatgaaca agacagaaca gaaaaggaag     6240

acaaagggaa agacagcaag gaaagcaaaa aatagagctt catttttgat atattgttta     6300

cagcctgtga aagtgattta tttgtgttaa taaaactctt ttgaggaagt ctatgccaaa     6360

atccttttta tcaaaatatt ctcgaaggca gtgcagtcac taactctgat ttcctaagaa     6420

aggtgggcag cattagcaga tggttatttt tgcactgatg attctttaag aatcgtaaga     6480

gaactctgta ggaattattg attatagcat acaaaagtga ttcagttttt tggtttttaa     6540

taaatcagaa gaccatgtag aaaactttta catctgcctt gtcatctttt cacaggattg     6600

taattagtct tgtttcccat gtaaataaac aacacacgca tacagaaaaa tctattattt     6660

atctattatt tggaaatcaa caaaagtatt tgccttggct ttgcaatgaa atgcttgata     6720

gaagtaatgg acattagtta tgaatgttta gttaaaatgc attattaggg agcttgactt     6780

tttatcaatg tacagaggtt attctatatt ttgaggtgct taaatttatt ctacattgca     6840

tcagaaccaa tttatatgtg cctataaaat gccatgggat taaaaatata tgtaggctat     6900

tcatttctac aaatgttttt cattcatctt gactcacatg ccaacaagga taagacttac     6960

ctttagagta ttgtgtttca tagcctttct tctttcatat ccctttttgt tcatagaata     7020

accacagaac ttgaaaaatt attctaagta catattacac tcctcaaaaa aaacaaagat     7080

aactgagaaa aaagttattg acagaagttc tatttgctat tatttacata gcctaacatt     7140

tgactgtgct gcccaaaata ctgataatag tctcttaaac tcttttgtca aattttcctg     7200

ctttcttatg cagtattgtt tagtcatcct ttcgctgtaa gcaaagttga tgaaatcctt     7260

cctgatatgc agttagttgt ttgaccacgg tacatacttg agcagataat aacttgggca     7320

cagtatttat tgcatcactt gtatacaatc ccgtgtttgg caagctttca aatcatgtaa     7380

tatgacagac tttacacaga tatgtgttta gtatgaataa aaaagcattg aaatagggat     7440

tcttgccaac ttgctctctt gccaccaact tactttccta aattatggaa gtaatctttt     7500

ttggatatac ttcaatgtat acaatgagga agatgtcacc ttctccttaa aattctatga     7560

tgtgaaatat attttgcctc aatcaacaca gtaccatggg cttctaattt atcaagcaca     7620

tattcatttt gcattagctg tagacatcta gttttttgaa aacacctatt aatagtaatt     7680

tgaaaagaaa taaccataat gctttttttc gtgagtttat ttcaggaata tgagatcttt     7740

cttctataaa gttattcatg cacaggcaaa aattgagcta cacaggtaga atgtagtttt     7800

acttagaaga tttttgtggg aggttttgaa gcaaatatat aaaacaactt tcactaattt     7860

gctttccata tttaaaaaat aataaattac atttatataa taaatgttta aagcacatat     7920

tttttgttgt tctggcaatt taaaaagaaa gaggatttaa acgtacctat agaaacaaag     7980

atttatggtt aaagaatgag atcagaagtc tagaatgttt ttaaattgtg atatatttta     8040

caacatccgt tattactttg agacatttgt cctaatctac gtataaaact caatctaggg     8100

ctaaagattc tttataccat cttaggttca ttcatcttag gctatttgaa ccacttttta     8160

atttaatatg aaagacacca tgcagtgttt tccgagacta catagatcat tttatcacat     8220

acctaccaag cctgttggaa ataggttttg ataatttaag tagggaccta tacaaaatat     8280

attacattta tcagattttt aaatacattc aattaagaat ttaacatcac cttaaatttg     8340

aattcaatct accgttattt caaactcaca aatataactg cattatgaat acttacataa     8400

tgtagtaaga caagatgttt gacaggttcg tgtgtaattt tctattaatg tttttacatt     8460

gccttgtttt tatgtaaaat aaaaaatatg ggcaactggt ttgttaacaa cacaatttct     8520

tcttagcatt tcaaaaatat atataaagtt gttctttttc ctatttcatg aactatgttt     8580

ttttttaaaa taacatggtt aagttttata tatatttacg tttgtttcag gaatgtctac     8640

ttgtgacttt ttatcaatta aaaataatat ttggaagaaa gagcttatta agtataagct     8700

tgaagtaaaa ttagacctct ctttccatgt agattactgt ttgtactgat ggtttcaccc     8760

ttcagaaggc actgtcatat taatatttaa attttataat cgctgaactt attacaccca     8820

acaatacaga aaggcagtta cactgaagaa cttaacttag aataaaatgg aagcaaacag     8880

gttttctaaa aactttttta agtgaccagg tctcgctctg tcacccaggc tagagtgcaa     8940

tggcatgatc atagctctct gcagcctcaa ctctgggctc aagcaaccct cctgcctcag     9000

cctcccaagt agctaagact acaggtacat gccaccatgc ctggctaata tttaaatttt     9060

tgtagataag gggtcttgct atgttgccca ggctagtctc aaactcctgg cttcaagtgt     9120

tcctactgtc atgacctgcc aacatgctgg ggttacaggc atgagccacc atgccccaaa     9180

caggtttgaa cacaaatctt tcggatgaaa attagagaac ctaattttag ctttttgata     9240

gttacctagt ttgcaaaaga tttgggtgac ttgtgagctg tttttaaatg ctgattgttg     9300

aacatcacaa cccaaaatac ttagcatgat tttatagagt tttgatagct ttattaaaaa     9360

gagtgaaaat aaaatgcata tgtaaataaa gcagttctaa atagctattt cagagaaatg     9420

ttaatagaag tgctgaaaga agggccaact aaattaggat ggccagggaa ttggcctggg     9480

tttaggacct atgtatgaag gccaccaatt ttttaaaaat atctgtggtt tattatgtta     9540

ttatcttctt gaggaaaaca atcaagaatt gcttcatgaa aataaataaa tagccatgaa     9600

tatcataaag ctgtttacat aggattcttt acaaatttca tagatctatg aatgctcaaa     9660

atgtttgagt ttgccataaa ttatattgta gttatattgt agttatactt gagactgaca     9720

cattgtaata taatctaaga ataaaagtta tacaaaataa aaaaaaaaaa a              9771


<210>  21
<211>  6500
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(6500)
<223>  Homo sapienssodium channel, voltage-gated, type XI, alpha subunit
       (SCN11A), transcript variant 1

<400>  21
tcctgctata cccacagtgg tggtcatctc ttctgatctt cacagccaat cagctcccaa       60

ggcccctgac ctcagctcag cttttgtaga tccttatgac accatccttt aagactggaa      120

tcctagggca ggctgtttta ttcccgcctc ctgaggcctt tctgaggatc tgtggcttgt      180

ctctgtcctg agggtgaaga tggatgacag atgctaccca gtaatctttc cagatgagcg      240

gaatttccgc cccttcactt ccgactctct ggctgcaatt gagaagcgga ttgccatcca      300

aaaggagaaa aagaagtcta aagaccagac aggagaagta ccccagcctc ggcctcagct      360

tgacctaaag gcctccagga agttgcccaa gctctatggc gacattcctc gtgagctcat      420

aggaaagcct ctggaagact tggacccatt ctaccgaaat cataagacat ttatggtgtt      480

aaacagaaag aggacaatct accgcttcag tgccaagcat gccttgttca tttttgggcc      540

tttcaattca atcagaagtt tagccattag agtctcagtc cattcattgt tcagcatgtt      600

cattatcggc accgttatca tcaactgcgt gttcatggct acagggcctg ctaaaaacag      660

caacagtaac aatactgaca ttgcagagtg tgtcttcact gggatttata tttttgaagc      720

tttgattaaa atattggcaa gaggtttcat tctggatgag ttttctttcc ttcgagatcc      780

atggaactgg ctggactcca ttgtcattgg aatagcgatt gtgtcatata ttccaggaat      840

caccatcaaa ctattgcccc tgcgtacctt ccgtgtgttc agagctttga aagcaatttc      900

agtagtttca cgtctgaagg tcatcgtggg ggccttgcta cgctctgtga agaagctggt      960

caacgtgatt atcctcacct tcttttgcct cagcatcttt gccctggtag gtcagcagct     1020

cttcatggga agtctgaacc tgaaatgcat ctcgagggac tgtaaaaata tcagtaaccc     1080

ggaagcttat gaccattgct ttgaaaagaa agaaaattca cctgaattca aaatgtgtgg     1140

catctggatg ggtaacagtg cctgttccat acaatatgaa tgtaagcaca ccaaaattaa     1200

tcctgactat aattatacga attttgacaa ctttggctgg tcttttcttg ccatgttccg     1260

gctgatgacc caagattcct gggagaagct ttatcaacag accctgcgta ctactgggct     1320

ctactcagtc ttcttcttca ttgtggtcat tttcctgggc tccttctacc tgattaactt     1380

aaccctggct gttgttacca tggcatatga ggagcagaac aagaatgtag ctgcagagat     1440

agaggccaag gaaaagatgt ttcaggaagc ccagcagctg ttaaaggagg aaaaggaggc     1500

tctggttgcc atgggaattg acagaagttc acttacttcc cttgaaacat catattttac     1560

cccaaaaaag agaaagctct ttggtaataa gaaaaggaag tccttctttt tgagagagtc     1620

tgggaaagac cagcctcctg ggtcagattc tgatgaagat tgccaaaaaa agccacagct     1680

cctagagcaa accaaacgac tgtcccagaa tctatcactg gaccactttg atgagcatgg     1740

agatcctctc caaaggcaga gagcactgag tgctgtcagc atcctcacca tcaccatgaa     1800

ggaacaagaa aaatcacaag agccttgtct cccttgtgga gaaaacctgg catccaagta     1860

cctcgtgtgg aactgttgcc cccagtggct gtgcgttaag aaggtcctga gaactgtgat     1920

gactgacccg tttactgagc tggccatcac catctgcatc atcatcaaca ctgtcttctt     1980

ggccatggag catcacaaga tggaggccag ttttgagaag atgttgaata tagggaattt     2040

ggttttcact agcattttta tagcagaaat gtgcctaaaa atcattgcgc tcgatcccta     2100

ccactacttt cgccgaggct ggaacatttt tgacagcatt gttgctcttc tgagttttgc     2160

agatgtaatg aactgtgtac ttcaaaagag aagctggcca ttcttgcgtt ccttcagagt     2220

gctcagggtc ttcaagttag ccaaatcctg gccaactttg aacacactaa ttaagataat     2280

cggcaactct gtcggagccc ttggaagcct gactgtggtc ctggtcattg tgatctttat     2340

tttctcagta gttggcatgc agctttttgg ccgtagcttc aattcccaaa agagtccaaa     2400

actctgtaac ccgacaggcc cgacagtctc atgtttacgg cactggcaca tgggggattt     2460

ctggcactcc ttcctagtgg tattccgcat cctctgcggg gaatggatcg aaaatatgtg     2520

ggaatgtatg caagaagcga atgcatcatc atcattgtgt gttattgtct tcatattgat     2580

cacggtgata ggaaaacttg tggtgctcaa cctcttcatt gccttactgc tcaattcctt     2640

tagcaatgag gaaagaaatg gaaacttaga aggagaggcc aggaaaacta aagtccagtt     2700

agcactggat cgattccgcc gggctttttg ttttgtgaga cacactcttg agcatttctg     2760

tcacaagtgg tgcaggaagc aaaacttacc acagcaaaaa gaggtggcag gaggctgtgc     2820

tgcacaaagc aaagacatca ttcccctggt catggagatg aaaaggggct cagagaccca     2880

ggaggagctt ggtatactaa cctctgtacc aaagaccctg ggcgtcaggc atgattggac     2940

ttggttggca ccacttgcgg aggaggaaga tgacgttgaa ttttctggtg aagataatgc     3000

acagcgcatc acacaacctg agcctgaaca acaggcctat gagctccatc aggagaacaa     3060

gaagcccacg agccagagag ttcaaagtgt ggaaattgac atgttctctg aagatgagcc     3120

tcatctgacc atacaggatc cccgaaagaa gtctgatgtt accagtatac tatcagaatg     3180

tagcaccatt gatcttcagg atggctttgg atggttacct gagatggttc ccaaaaagca     3240

accagagaga tgtttgccca aaggctttgg ttgctgcttt ccatgctgta gcgtggacaa     3300

gagaaagcct ccctgggtca tttggtggaa cctgcggaaa acctgctacc aaatagtgaa     3360

acacagctgg tttgagagct ttattatctt tgtgattctg ctgagcagtg gggcactgat     3420

atttgaagat gttcaccttg agaaccaacc caaaatccaa gaattactaa attgtactga     3480

cattattttt acacatattt ttatcctgga gatggtacta aaatgggtag ccttcggatt     3540

tggaaagtat ttcaccagtg cctggtgctg ccttgatttc atcattgtga ttgtctctgt     3600

gaccaccctc attaacttaa tggaattgaa gtccttccgg actctacgag cactgaggcc     3660

tcttcgtgcg ctgtcccagt ttgaaggaat gaaggtggtg gtcaatgctc tcataggtgc     3720

catacctgcc attctgaatg ttttgcttgt ctgcctcatt ttctggctcg tattttgtat     3780

tctgggagta tacttctttt ctggaaaatt tgggaaatgc attaatggaa cagactcagt     3840

tataaattat accatcatta caaataaaag tcaatgtgaa agtggcaatt tctcttggat     3900

caaccagaaa gtcaactttg acaatgtggg aaatgcttac ctcgctctgc tgcaagtggc     3960

aacatttaag ggctggatgg atattatata tgcagctgtt gattccacag agaaagaaca     4020

acagccagag tttgagagca attcactcgg ttacatttac ttcgtagtct ttatcatctt     4080

tggctcattc ttcactctga atctcttcat tggcgttatc attgacaact tcaaccaaca     4140

gcagaaaaag ttaggtggcc aagacatttt tatgacagaa gaacagaaga aatactataa     4200

tgcaatgaaa aaattaggat ccaaaaaacc tcaaaaaccc attccacggc ctctgaacaa     4260

atgtcaaggt ctcgtgttcg acatagtcac aagccagatc tttgacatca tcatcataag     4320

tctcattatc ctaaacatga ttagcatgat ggctgaatca tacaaccaac ccaaagccat     4380

gaaatccatc cttgaccatc tcaactgggt ctttgtggtc atctttacgt tagaatgtct     4440

catcaaaatc tttgctttga ggcaatacta cttcaccaat ggctggaatt tatttgactg     4500

tgtggtcgtg cttctttcca ttgttagtac aatgatttct accttggaaa atcaggagca     4560

cattcctttc cctccgacgc tcttcagaat tgtccgcttg gctcggattg gccgaatcct     4620

gaggcttgtc cgggctgcac gaggaatcag gactctcctc tttgctctga tgatgtcgct     4680

tccttctctg ttcaacattg gtcttctact ctttctgatt atgtttatct atgccattct     4740

gggtatgaac tggttttcca aagtgaatcc agagtctgga atcgatgaca tattcaactt     4800

caagactttt gccagcagca tgctctgtct cttccagata agcacatcag caggttggga     4860

ttccctgctc agccccatgc tgcgatcaaa agaatcatgt aactcttcct cagaaaactg     4920

ccacctccct ggcatagcca catcctactt tgtcagttac attatcatct cctttctcat     4980

tgttgtcaac atgtacattg ctgtgatttt agagaacttc aatacagcca ctgaagaaag     5040

tgaggaccct ttgggtgaag atgactttga catattttat gaagtgtggg aaaagtttga     5100

cccagaagca acacaattta tcaaatattc tgccctttct gactttgctg atgccttgcc     5160

tgagcctttg cgtgtcgcaa agccaaataa atatcaattt ctagtaatgg acttgcccat     5220

ggtgagtgaa gatcgcctcc actgcatgga tattcttttc gccttcaccg ctagggtact     5280

cggtggctct gatggcctag atagtatgaa agcaatgatg gaagagaagt tcatggaagc     5340

caatcctctc aagaagttgt atgaacccat agtcaccacc accaagagaa aggaagagga     5400

aagaggtgct gctattattc aaaaggcctt tcgaaagtac atgatgaagg tgaccaaggg     5460

tgaccaaggt gaccaaaatg acttggaaaa cgggcctcat tcaccactcc agactctttg     5520

caatggagac ttgtctagct ttggggtggc caagggcaag gtccactgtg actgagccct     5580

cacctccacg cctacctcat agcttcacag ccttgccttc agcctctgag ctccaggggt     5640

cagcagctta gtgtatcaac agggagtgga ttcaccaaat tagccattcc attttctttt     5700

ctggctaaaa taaatgatat ttcaatttca ttttaaataa tacttacaga gatataagat     5760

aaggctactt gacaaccagt ggtactatta taataaggaa gaagacacca ggaaggactg     5820

taaaaggaca taccaatttt aggattgaaa tagttcaggc cgggcgcagt ggctcatgcc     5880

tgtaatccca gcactttgag aggccaaggc aggtggatca cgaggtcaag agatcgagac     5940

catcctggcc aacatgatga aactccgtct ctactaaaaa tacaaaaatt agctgggcat     6000

ggtggcgtgc gcctgtagtc ccagctactt gggaggctga ggcaggagaa tcgcttaaac     6060

ctgggagacg gaggttgcag tgagccaaga tcgtgccact gcactccagc ctggtgacag     6120

agtgagactc tgtttcaaaa aagaaaagaa aagaaacatg gttcaaatta tatctaaaca     6180

aaaaagaata agaaacaaaa aacacattaa aattttaagt tgtattttct atgtttctag     6240

atacatcatt tttgtttgat attttcctga tgcaagtatg tggtttatca catgtagctc     6300

ttttgcatgc taaatgaaaa ttcaaaactt gccaataaat gaatagctta ttgcagacat     6360

tttttaccaa cattaattat tttgggtttg tttaaaacct agaggcacaa tcttgacttg     6420

tcaattacta ccctttcaca agctaccatc tcagatatat atatatatat aaattcaata     6480

aagctttctg tttgtgttcc                                                 6500


<210>  22
<211>  11447
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(11447)
<223>  Homo sapienssodium channel, voltage gated, type VIII, alpha 
       subunit (SCN8A), transcript variant 2

<400>  22
gagcgctcca agatggcgcc caccgcagtc ccgcccgccg catcctcggc gcctttgcag       60

tccggccgcg cctcccgggc cccgcgttag ggccgccgct gcctccctcg ccgccgccgc      120

tgccagctga cctgtcctgg acgcagcata actaacgaag ctgctgcagg atgagaagat      180

ggcagcgcgg ctgcttgcac caccaggccc tgatagtttc aagcctttca cccctgagtc      240

actggcaaac attgagaggc gcattgctga gagcaagctc aagaaaccac caaaggccga      300

tggcagtcat cgggaggacg atgaggacag caagcccaag ccaaacagcg acctggaagc      360

agggaagagt ttgcctttca tctacgggga catcccccaa ggcctggttg cagttcccct      420

ggaggacttt gacccatact atttgacgca gaaaaccttt gtagtattaa acagagggaa      480

aactctcttc agatttagtg ccacgcctgc cttgtacatt ttaagtcctt ttaacctgat      540

aagaagaata gctattaaaa ttttgataca ttcagtattt agcatgatca ttatgtgcac      600

tattttgacc aactgtgtat tcatgacttt tagtaaccct cctgactggt cgaagaatgt      660

ggagtacacg ttcacaggga tttatacatt tgaatcacta gtgaaaatca ttgcaagagg      720

tttctgcata gatggcttta cctttttacg ggacccatgg aactggttag atttcagtgt      780

catcatgatg gcgtatataa cagagtttgt aaacctaggc aatgtttcag ctctacgcac      840

tttcagggta ctgagggctt tgaaaactat ttcggtaatc ccaggcctga agacaattgt      900

gggtgccctg attcagtctg tgaagaaact gtcagatgtg atgatcctga cagtgttctg      960

cctgagtgtt tttgccttga tcggactgca gctgttcatg gggaaccttc gaaacaagtg     1020

tgttgtgtgg cccataaact tcaacgagag ctatcttgaa aatggcacca aaggctttga     1080

ttgggaagag tatatcaaca ataaaacaaa tttctacaca gttcctggca tgctggaacc     1140

tttactctgt gggaacagtt ctgatgctgg gcaatgccca gagggatacc agtgtatgaa     1200

agcaggaagg aaccccaact atggttacac aagttttgac acttttagct gggccttctt     1260

ggcattattt cgccttatga cccaggacta ttgggaaaac ttgtatcaat tgactttacg     1320

agcagccggg aaaacataca tgatcttctt cgtcttggtc atctttgtgg gttctttcta     1380

tctggtgaac ttgatcttgg ctgtggtggc catggcttat gaagaacaga atcaggcaac     1440

actggaggag gcagaacaaa aagaggctga atttaaagca atgttggagc aacttaagaa     1500

gcaacaggaa gaggcacagg ctgctgcgat ggccacttca gcaggaactg tctcagaaga     1560

tgccatagag gaagaaggtg aagaaggagg gggctcccct cggagctctt ctgaaatctc     1620

taaactcagc tcaaagagtg caaaggaaag acgtaacagg agaaagaaga ggaagcaaaa     1680

ggaactctct gaaggagagg agaaagggga tcccgagaag gtgtttaagt cagagtcaga     1740

agatggcatg agaaggaagg cctttcggct gccagacaac agaataggga ggaaattttc     1800

catcatgaat cagtcactgc tcagcatccc aggctcgccc ttcctctccc gccacaacag     1860

caagagcagc atcttcagtt tcaggggacc tgggcggttc cgagacccgg gctccgagaa     1920

tgagttcgcg gatgacgagc acagcacggt ggaggagagc gagggccgcc gggactccct     1980

cttcatcccc atccgggccc gcgagcgccg gagcagctac agcggctaca gcggctacag     2040

ccagggcagc cgctcctcgc gcatcttccc cagcctgcgg cgcagcgtga agcgcaacag     2100

cacggtggac tgcaacggcg tggtgtccct catcggcggc cccggctccc acatcggcgg     2160

gcgtctcctg ccagaggcta caactgaggt ggaaattaag aagaaaggcc ctggatctct     2220

tttagtttcc atggaccaat tagcctccta cgggcggaag gacagaatca acagtataat     2280

gagtgttgtt acaaatacac tagtagaaga actggaagag tctcagagaa agtgcccgcc     2340

atgctggtat aaatttgcca acactttcct catctgggag tgccacccct actggataaa     2400

actgaaagag attgtgaact tgatagttat ggaccctttt gtggatttag ccatcaccat     2460

ctgcatcgtc ctgaatacac tgtttatggc aatggagcac catcctatga caccacaatt     2520

tgaacatgtc ttggctgtag gaaatctggt tttcactgga attttcacag cggaaatgtt     2580

cctgaagctc atagccatgg atccctacta ttatttccaa gaaggttgga acatttttga     2640

cggatttatt gtctccctca gtttaatgga actgagtcta gcagacgtgg aggggctttc     2700

agtgctgcga tctttccgat tgctccgagt cttcaaattg gccaaatcct ggcccaccct     2760

gaacatgcta atcaagatta ttggaaattc agtgggtgcc ctgggcaacc tgacactggt     2820

gctggccatt attgtcttca tctttgccgt ggtggggatg caactctttg gaaaaagcta     2880

caaagagtgt gtctgcaaga tcaaccagga ctgtgaactc cctcgctggc atatgcatga     2940

ctttttccat tccttcctca ttgtctttcg agtgttgtgc ggggagtgga ttgagaccat     3000

gtgggactgc atggaagtgg caggccaggc catgtgcctc attgtcttta tgatggtcat     3060

ggtgattggc aacttggtgg tgctgaacct gtttctggcc ttgctcctga gctccttcag     3120

tgcagacaac ctggctgcca cagatgacga tggggaaatg aacaacctcc agatctcagt     3180

gatccgtatc aagaagggtg tggcctggac caaactaaag gtgcacgcct tcatgcaggc     3240

ccactttaag cagcgtgagg ctgatgaggt gaagcctctg gatgagttgt atgaaaagaa     3300

ggccaactgt atcgccaatc acaccggtgc agacatccac cggaatggtg acttccagaa     3360

gaatggcaat ggcacaacca gcggcattgg cagcagcgtg gagaagtaca tcattgatga     3420

ggaccacatg tccttcatca acaaccccaa cttgactgta cgggtaccca ttgctgtggg     3480

cgagtctgac tttgagaacc tcaacacaga ggatgttagc agcgagtcgg atcctgaagg     3540

cagcaaagat aaactagatg acaccagctc ctctgaagga agcaccattg atatcaaacc     3600

agaagtagaa gaggtccctg tggaacagcc tgaggaatac ttggatccag atgcctgctt     3660

cacagaaggt tgtgtccagc ggttcaagtg ctgccaggtc aacatcgagg aagggctagg     3720

caagtcttgg tggatcctgc ggaaaacctg cttcctcatc gtggagcaca actggtttga     3780

gaccttcatc atcttcatga ttctgctgag cagtggcgcc ctggccttcg aggacatcta     3840

cattgagcag agaaagacca tccgcaccat cctggaatat gctgacaaag tcttcaccta     3900

tatcttcatc ctggagatgt tgctcaagtg gacagcctat ggcttcgtca agttcttcac     3960

caatgcctgg tgttggctgg acttcctcat tgtggctgtg gtggtgaatg ccttggtggg     4020

cgccatcccc tccatcatga atgtgctgct ggtgtgtctc atcttctggc tgattttcag     4080

catcatggga gttaacttgt ttgcgggaaa gtaccactac tgctttaatg agacttctga     4140

aatccgattt gaaattgaag atgtcaacaa taaaactgaa tgtgaaaagc ttatggaggg     4200

gaacaataca gagatcagat ggaagaacgt gaagatcaac tttgacaatg ttggggcagg     4260

atacctggcc cttcttcaag tagcaacctt caaaggctgg atggacatca tgtatgcagc     4320

tgtagattcc cggaagcctg atgagcagcc taagtatgag gacaatatct acatgtacat     4380

ctattttgtc atcttcatca tcttcggctc cttcttcacc ctgaacctgt tcattggtgt     4440

catcattgat aacttcaatc aacaaaagaa aaagttcgga ggtcaggaca tcttcatgac     4500

cgaagaacag aagaagtact acaatgccat gaaaaagctg ggctcaaaga agccacagaa     4560

acctattccc cgccccttga acaaaatcca aggaatcgtc tttgattttg tcactcagca     4620

agcctttgac attgttatca tgatgctcat ctgccttaac atggtgacaa tgatggtgga     4680

gacagacact caaagcaagc agatggagaa catcctctac tggattaacc tggtgtttgt     4740

tatcttcttc acctgtgagt gtgtgctcaa aatgtttgcg ttgaggcact actacttcac     4800

cattggctgg aacatcttcg acttcgtggt agtcatcctc tccattgtgg gaatgttcct     4860

ggcagatata attgagaaat actttgtttc cccaacccta ttccgagtca tccgattggc     4920

ccgtattggg cgcatcttgc gtctgatcaa aggcgccaaa gggattcgta ccctgctctt     4980

tgccttaatg atgtccttgc ctgccctgtt caacatcggc cttctgctct tcctggtcat     5040

gttcatcttc tccatttttg ggatgtccaa ttttgcatat gtgaagcacg aggctggtat     5100

cgatgacatg ttcaactttg agacatttgg caacagcatg atctgcctgt ttcaaatcac     5160

aacctcagct ggttgggatg gcctgctgct gcccatccta aaccgccccc ctgactgcag     5220

cctagataag gaacacccag ggagtggctt taagggagat tgtgggaacc cctcagtggg     5280

catcttcttc tttgtaagct acatcatcat ctctttccta attgtcgtga acatgtacat     5340

tgccatcatc ctggagaact tcagtgtagc cacagaggaa agtgcagacc ctctgagtga     5400

ggatgacttt gagaccttct atgagatctg ggagaagttc gaccccgatg ccacccagtt     5460

cattgagtac tgtaagctgg cagactttgc agatgccttg gagcatcctc tccgagtgcc     5520

caagcccaat accattgagc tcatcgctat ggatctgcca atggtgagcg gggatcgcat     5580

ccactgcttg gacatccttt ttgccttcac caagcgggtc ctgggagata gcggggagtt     5640

ggacatcctg cggcagcaga tggaagagcg gttcgtggca tccaatcctt ccaaagtgtc     5700

ttacgagcca atcacaacca cactgcgtcg caagcaggag gaggtatctg cagtggtcct     5760

gcagcgtgcc taccggggac atttggcaag gcggggcttc atctgcaaaa agacaacttc     5820

taataagctg gagaatggag gcacacaccg ggagaaaaaa gagagcaccc catctacagc     5880

ctccctcccg tcctatgaca gtgtaactaa acctgaaaag gagaaacagc agcgggcaga     5940

ggaaggaaga agggaaagag ccaaaagaca aaaagaggtc agagaatcca agtgttagag     6000

gagaacaaaa attcagtatt atacagatct aaaactcgca agtgaaagat tgtttacaaa     6060

cttcctgaat attatcaatg cagaacagct gtggagactc taacctgaag atctatacca     6120

aacgtcgtct gcttaccacg taacacagct gcatcttgag cagtgacctg ccaagggcaa     6180

aggaccccgc tccctagact tacagatttt ctaatgcttg ggcaggtggt tactgcatgt     6240

tccacatcag tcaatgcaac ttaggacaaa actaaccaga tacagaaaca gaagagaggc     6300

tgccgggacc agcatatttc cgttgcagcc aaatggattt tattttttca ttttattgat     6360

tctcagaagc agaaagcatc actttaaaag ttcgtttgtt catgcaaact atatttgcat     6420

tcttacatta gttaagctaa gcagcaaaaa gaaaacacac acacacactc acatttagcc     6480

catgtcattt aattgtcagt ttctttgaca taaagcgcat cttctccaca tgggcttcac     6540

gtggtttgga gatgggtggg ggaaaacaat caggtttctt caggctgagg aggacttgct     6600

caggccgatt ccaaacattg tgctcgttca atgcgtagaa atgatttgca tgatggcatg     6660

ccgtgatcag aagtcatgca tgagatccat acaccacagg acactactaa tctagtccct     6720

tgcactgggt cagcctttgg acaggaccca gccctgcacc gttcactgta tttggagaaa     6780

atggtaagag ttccataccg gctacaattc tttgagttct taaaagtcct tcatacacct     6840

tctgggtagg gaaacaacca actaattgac taacaccacc aacaacaaaa aacaaaccca     6900

atccaacaag cagatggatc cgttgcgtgt atatgtttaa cagacatctc taacatacag     6960

ccattgttgc acattttgca agatgaacta tttaatgctg ctctgtgtcc agtacatggg     7020

ggagactttg atcccaaatg gcttgtacta tttatgtcac tgtaaaacca aatcctaggg     7080

ctaaaaaaaa aattcatttg tatcttgcaa tatttatgac gatcgtttag ccttcatact     7140

ggagaattga cacttatttg gggtagagat aaaagtgctt ttcaaagtag caccagttat     7200

ctctaggggt aatttgggga acttaaaatg acctttcatt gggagttatg gggtgctcat     7260

ttcatttcgt atcatgtcct ctgcattgtg gctttctcca ggcatgggtc gataccgcga     7320

ggggttcaga tattctgaac tgacctctct cttctgcaga ggggtcatcg catactcaca     7380

cactgcatgg ctccccctgc ctccatcaca tttctccact gagcagggct tcccttgccc     7440

acagaggtgg gtgagggtag cagcattggg gttacggctg tggtttcttt cacttattat     7500

tagaataata gtcactggtg agacctgagg tagagatgga gccgcctctg aaccaagccc     7560

acttggtttc tttactgcac tggttttcat gagaaagcaa tttaatatta attctttagg     7620

atgttccagc ttccctcagt gcattccctt gcagccagtt ttgctatctg cttagcgacc     7680

tgcccattgt cattgaagtg tggcttctgg gggagcgtca tatcttccat tccatctcct     7740

gctttaggaa agacagtttt tagtccaggg gtttctcacc taatgactgg atttcaaagc     7800

caagatgctg cagttgaatg tgtcaggaag tctctataca aagagtgaaa agagacttta     7860

gcatgtgaac caaatccaaa taaattcttc ctgaaccata cactagaggg ggaagaagaa     7920

ccaacccata atcagacaca ccgatctgcc ttgcagtaga agcactttga aggtaatttc     7980

acagtccacc agactagttt tgcatagaac aaaccacagt aagtcggcaa gcagagcttt     8040

ctatcttgtt ggaccactag aaactgtcca gctctcttaa gcctgcttct gcagcagcat     8100

ccgtagaatt tttgtactac acccaatacc agactgggaa ggcctatctt tcagtgaccc     8160

tgctaactgc taggatgaat gtatagtaac atgtacaggc tacattgtaa acagcacaaa     8220

acagaagctg acatgtgtgg ttattctttt taagagaatt ataaatactg taatatataa     8280

ttttatttta ttggcatgcc tttttgtaaa tacaaattat taacttatta aataggaaat     8340

ggcttctggc ttatgccatt gtcatgttta tttttatttt ttatactttt ctttcttctt     8400

agaacttaga tgctgtcagc caatgtacat ccccaaacca gacagacaga caaaaaattt     8460

tttattgcta atggtctttt ccaaaacaac aaaaaatata tatttttgtt ccaatgtgca     8520

ataaattcta accacgtcta tgcaagattt ggctaaactt aataattgtt cttaggtctt     8580

gagatgggca acagagctgt aagatcccgc caagtacacc atgtgctcat gctagtgatg     8640

tcattaagct actagggcat agtgatgaga tttttctgag atctaaccgt ttccctccgc     8700

tagctcctga ccccagccca gcaggctgtc tcctcagtaa cacatgggcc ttggtatctg     8760

gcacccatca gccagcctca taggaaagaa gccacctccg ctgtatttga agtttcactt     8820

tttaaaaaaa aaatgtttcc caccttttta tccttcaccc actgtccttc cacctgctca     8880

ctcactcact ctctcaccca tcctgctcca cacttctttg gtagtaaatg acaccatcac     8940

cagcagttta cacccgcagt taacaggcat cgaactgaaa gaatcagtga tgacgttttt     9000

gtgcatcttc gctgagtggg taagtggcaa tgctttgcca aatattaacg aagccaatca     9060

aagagcagcg cagccacagt atcactgcac atatatatat agatatataa atataatata     9120

aatatttatt ttttgtagcc aggtccttgg tgcagtattt atactccaca atccaccttt     9180

taaaaaaagg acaaaaagca aaaagatgtg tgatgctgtt aataatttaa aatgcagagc     9240

caaagccact gagcagcagc tgacatggtt gctggtttgt gtgtgaaaaa cattttcccc     9300

ctcttctttc cttaacctcc ttgttgctta ggatgaggag actctgtaat ttaaagcaga     9360

ggacgagagg aggaagaaac ttccatgtta acatggccta ctctcactcc tttctaaacg     9420

agccactttt ggcgtcagaa gttgactgga gagagataaa caaactccca gtcaaagccc     9480

ctaaagcgac agtgcccaga gttcttttat tttttgctgc aaccaacgta aacctgtaaa     9540

agaccaacag tgaagattag tgtattagtg aatgcatgga ggccaatgct gccctaatga     9600

gacgtgataa aaagtccatc actcctctaa gccaaaagga aacaaaataa aaatgaccct     9660

ttttactgta caagggaagc ctgtcttggt gtgtttgttg cttgactatc ccaattcttg     9720

agtcctggga ggggtctggg aattgggacc ttagcacatt tggggaaagg aggggaatag     9780

agggaagaga aatcaaaggg gctctcgcaa agttctggct aagaaggaga gattggaaga     9840

aaagcaaggt cctgaccccc cccagatccc cactcaccca ttgcatgtgg cattccccac     9900

tactggccgg tgcttagagg cccataaaac ctctcttcac ctaatccacc tggcagagcc     9960

ctcagagatg acgtcagcca acccagctgg actggcctta cttctgcctt tttcacctgt    10020

atgttaaaaa acaaaaacaa aaaaacccta tccctgtgcc ccaaagctag ggcatgtgcg    10080

atgcccaaca gcctccactc tgcaagctca tactgggccc tgccctccat cgccccagac    10140

aggcccacag acgagggctg gtctccttca catttgtgtg ggggtggggg cacgcttcct    10200

cttccttctc tccctgtccc cctttgggga catccctctc taggcctagg ccatgtctcc    10260

tggttcagga acactctctc aggaggatct cgaagtgccc actctagtcc gctccagtag    10320

ctccactctg gagcgagatg gctggtaggt cagtccccat cctcctcccc tcggccccca    10380

gcctccaggc ctgctgtgga ggtgagatcg ccatgggtca tgactttgtg acttgagtcc    10440

tgggcatctt ctgtaatgat gcctctttct tttctcagat gttgcccaca gtttagcaaa    10500

aagcttcgtt cattttcagg tactccccac cccctaaaga attggctgca acttgccagc    10560

cagggggaca tcaggagaga agaggaagtc tgggttggga ggggcccaag ttttgcaaca    10620

gagtttccat tgttcagctc tgtgctttct tggattccct ttccaagatt accaagattt    10680

cctccattaa aactcctgag gcaccccctg cccctgcccc ccactgctgt ttgctgtaca    10740

tagaggctaa gtggggtggg gtgggtgggt gtgcacatgt ggtgtgtgtg tgtgtgtgtg    10800

aagaatgtat ataggtaaag gggagtgtgg tccagtggtt ccagaaaagg gacagaactg    10860

tgttctgtcc ctagcttgac cgctggctcg ctgtgtggcc ttgggcaagt cacttaacct    10920

ctctgtgcct cagtttcccc atctgtaaaa tggggataat aatactgacc tacctcacag    10980

gggtgttgtg aggctttaac taaatgtttt gtaaagcgtt ttgagataca gaggcaaagg    11040

cgctagggaa gggcaaagta ttattggact taaggaagct gaaatggtac cataaatgct    11100

gctattctga gagccatttt aaactgcact gctccaacca cccccgcttc tcatcaccag    11160

gacagcaggt cgagaaaatg tctttccttt cacttgcttc tggggtttgt gattattcaa    11220

gacaattttt tccccttgct gtatctcctt ccctcacctc ctcgacttgt tccctgttct    11280

gtttatgcgg aaatggcaga aatgcttgag aaatgagaat gtgtaagtgg attggaagtt    11340

tatagtatga aatttcaatt ttactttgta ctgtacatct ttttacttta gaatttgcaa    11400

taaagggtta cgtcaatctt gttttcaact ctcaaaaaaa aaaaaaa                  11447


<210>  23
<211>  3459
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(3459)
<223>  Homo sapiens hyperpolarization activated cyclic nucleotide-gated 
       potassium channel 2 (HCN2)

<400>  23
ggccggcggc ggcggcggcg gctccgctcc gcactgcccg gcgccgcctc gccatggacg       60

cgcgcggggg cggcgggcgg cccggggaga gcccgggcgc gacccccgcg ccggggccgc      120

cgccgccgcc gccgcccgcg cccccccaac agcagccgcc gccgccgccg ccgcccgcgc      180

cccccccggg ccccgggccc gcgccccccc agcacccgcc ccgggccgag gcgttgcccc      240

cggaggcggc ggatgagggc ggcccgcggg gccggctccg cagccgcgac agctcgtgcg      300

gccgccccgg caccccgggc gcggcgagca cggccaaggg cagcccgaac ggcgagtgcg      360

ggcgcggcga gccgcagtgc agccccgcgg ggcccgaggg cccggcgcgg gggcccaagg      420

tgtcgttctc gtgccgcggg gcggcctcgg ggcccgcgcc ggggccgggg ccggcggagg      480

aggcgggcag cgaggaggcg ggcccggcgg gggagccgcg cggcagccag gccagcttca      540

tgcagcgcca gttcggcgcg ctcctgcagc cgggcgtcaa caagttctcg ctgcggatgt      600

tcggcagcca gaaggccgtg gagcgcgagc aggagcgcgt caagtcggcg ggggcctgga      660

tcatccaccc gtacagcgac ttcaggttct actgggactt caccatgctg ctgttcatgg      720

tgggaaacct catcatcatc ccagtgggca tcaccttctt caaggatgag accactgccc      780

cgtggatcgt gttcaacgtg gtctcggaca ccttcttcct catggacctg gtgttgaact      840

tccgcaccgg cattgtgatc gaggacaaca cggagatcat cctggacccc gagaagatca      900

agaagaagta tctgcgcacg tggttcgtgg tggacttcgt gtcctccatc cccgtggact      960

acatcttcct tatcgtggag aagggcattg actccgaggt ctacaagacg gcacgcgccc     1020

tgcgcatcgt gcgcttcacc aagatcctca gcctcctgcg gctgctgcgc ctctcacgcc     1080

tgatccgcta catccatcag tgggaggaga tcttccacat gacctatgac ctggccagcg     1140

cggtgatgag gatctgcaat ctcatcagca tgatgctgct gctctgccac tgggacggct     1200

gcctgcagtt cctggtgcct atgctgcagg acttcccgcg caactgctgg gtgtccatca     1260

atggcatggt gaaccactcg tggagtgaac tgtactcctt cgcactcttc aaggccatga     1320

gccacatgct gtgcatcggg tacggccggc aggcgcccga gagcatgacg gacatctggc     1380

tgaccatgct cagcatgatt gtgggtgcca cctgctacgc catgttcatc ggccacgcca     1440

ctgccctcat ccagtcgctg gactcctcgc ggcgccagta ccaggagaag tacaagcagg     1500

tggagcagta catgtccttc cacaagctgc cagctgactt ccgccagaag atccacgact     1560

actatgagca ccgttaccag ggcaagatgt ttgacgagga cagcatcctg ggcgagctca     1620

acgggcccct gcgggaggag atcgtcaact tcaactgccg gaagctggtg gcctccatgc     1680

cgctgttcgc caacgccgac cccaacttcg tcacggccat gctgaccaag ctcaagttcg     1740

aggtcttcca gccgggtgac tacatcatcc gcgaaggcac catcgggaag aagatgtact     1800

tcatccagca cggcgtggtc agcgtgctca ctaagggcaa caaggagatg aagctgtccg     1860

atggctccta cttcggggag atctgcctgc tcacccgggg ccgccgcacg gcgagcgtgc     1920

gggctgacac ctactgccgc ctctattcgc tgagcgtgga caacttcaac gaggtgctgg     1980

aggagtaccc catgatgcgg cgcgccttcg agacggtggc catcgaccgc ctggaccgca     2040

tcggcaagaa gaattccatc ctcctgcaca aggtgcagca tgacctcaac tcgggcgtat     2100

tcaacaacca ggagaacgcc atcatccagg agatcgtcaa gtacgaccgc gagatggtgc     2160

agcaggccga gctgggtcag cgcgtgggcc tcttcccgcc gccgccgccg ccgccgcagg     2220

tcacctcggc catcgccacg ctgcagcagg cggcggccat gagcttctgc ccgcaggtgg     2280

cgcggccgct cgtggggccg ctggcgctcg gctcgccgcg cctcgtgcgc cgcccgcccc     2340

cggggcccgc acctgccgcc gcctcacccg ggcccccgcc ccccgccagc cccccgggcg     2400

cgcccgccag cccccgggca ccgcggacct cgccctacgg cggcctgccc gccgcccccc     2460

ttgctgggcc cgccctgccc gcgcgccgcc tgagccgcgc gtcgcgccca ctgtccgcct     2520

cgcagccctc gctgcctcac ggcgcccccg gccccgcggc ctccacacgc ccggccagca     2580

gctccacacc gcgcttgggg cccacgcccg ctgcccgggc cgccgcgccc agcccggacc     2640

gcagggactc ggcctcaccc ggcgccgccg gcggcctgga cccccaggac tccgcgcgct     2700

cgcgcctctc gtccaacttg tgaccctcgc cgaccgcccc gcgggcccag gcgggccggg     2760

ggcggggccg tcatccagac caaagccatg ccattgcgct gccccggccg ccagtccgcc     2820

cagaagccat agacgagacg taggtagccg tagttggacg gacgggcagg gccggcgggg     2880

cagccccctc cgcgcccccg gccgtccccc ctcatcgccc cgcgcccacc cccatcgccc     2940

ctgcccccgg cggcggcctc gcgtgcgagg gggctccctt cacctcggtg cctcagttcc     3000

cccagctgta agacagggac ggggcggccc agtggctgag aggagccggc tgtggagccc     3060

cgcccgcccc ccaccctcta ggtggccccc gtccgaggag gatcgttttc taagtgcaat     3120

acttggcccg ccggcttccc gctgccccca tcgcgctcac gcaataaccg gcccggcccc     3180

cgtccgcgcg cgtcccccgg tgacctcggg gagcagcacc ccgcctccct ccagcactgg     3240

caccgagagg caggcctggc tgcgcagggc gcggggggga ggctggggtc ccgccgccgt     3300

gatgaatgta ctgacgagcc gaggcagcag tgcccccacc gtggcccccc acgccccatt     3360

aacccccaca cccccattcc gcgcaataaa cgacagcatt ggcgccaaaa aaaaaaaaaa     3420

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa                            3459


<210>  24
<211>  3195
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(3195)
<223>  Mus musculus hyperpolarization-activated, cyclic nucleotide-gated
       K+ 2 (Hcn2)

<400>  24
ccgctccgct ccgcactgcc cggcgccgcc tcgccatgga tgcgcgcggg ggcggcgggc       60

ggccgggcga tagtccgggc acgacccctg cgccggggcc gccgccaccg ccgccgccgc      120

ccgcgccccc tcagcctcag ccaccacccg cgccaccccc gaaccccacg accccctcgc      180

acccggagtc ggcggacgag cccggcccgc gcgcccggct ctgcagccgc gacagcgcct      240

gcacccctgg cgcggccaag ggcggcgcga atggcgagtg cgggcgcggg gagccgcagt      300

gcagccccga gggccccgcg cgcggcccca aggtttcgtt ctcatgccgc ggggcggcct      360

ccgggccctc ggcggccgag gaggcgggca gcgaggaggc gggcccggcg ggtgagccgc      420

gcggcagcca ggctagcttc ctgcagcgcc aattcggggc gcttctgcag cccggcgtca      480

acaagttctc cctgcggatg ttcggcagcc agaaggccgt ggagcgcgag caggaacgcg      540

tgaagtcggc gggggcctgg atcatccacc cctacagcga cttcaggttc tactgggact      600

tcaccatgct gttgttcatg gtgggaaatc tcattatcat tcccgtgggc atcactttct      660

tcaaggacga gaccaccgcg ccctggatcg tcttcaacgt ggtctcggac actttcttcc      720

tcatggactt ggtgttgaac ttccgcaccg gcattgttat tgaggacaac acggagatca      780

tcctggaccc cgagaagata aagaagaagt acttgcgtac gtggttcgtg gtggacttcg      840

tgtcatccat cccggtggac tacatcttcc tcatagtgga gaagggaatc gactccgagg      900

tctacaagac agcgcgtgct ctgcgcatcg tgcgcttcac caagatcctc agtctgctgc      960

ggctgctgcg gctatcacgg ctcatccgat atatccacca gtgggaagag attttccaca     1020

tgacctacga cctggcaagt gcagtgatgc gcatctgtaa cctgatcagc atgatgctac     1080

tgctctgcca ctgggacggt tgcctgcagt tcctggtgcc catgctgcaa gacttcccca     1140

gcgactgctg ggtgtccatc aacaacatgg tgaaccactc gtggagcgag ctctactcgt     1200

tcgcgctctt caaggccatg agccacatgc tgtgcatcgg ctacgggcgg caggcgcccg     1260

agagcatgac agacatctgg ctgaccatgc tcagcatgat cgtaggcgcc acctgctatg     1320

ccatgttcat tgggcacgcc actgcgctca tccagtccct ggattcgtca cggcgccaat     1380

accaggagaa gtacaagcaa gtagagcaat acatgtcctt ccacaaactg cccgctgact     1440

tccgccagaa gatccacgat tactatgaac accggtacca agggaagatg tttgatgagg     1500

acagcatcct tggggaactc aacgggccac tgcgtgagga gattgtgaac ttcaactgcc     1560

ggaagctggt ggcttccatg ccgctgtttg ccaatgcaga ccccaacttc gtcacagcca     1620

tgctgacaaa gctcaaattt gaggtcttcc agcctggaga ttacatcatc cgagagggga     1680

ccatcgggaa gaagatgtac ttcatccagc atggggtggt gagcgtgctc accaagggca     1740

acaaggagat gaagctgtcg gatggctcct atttcgggga gatctgcttg ctcacgaggg     1800

gccggcgtac ggccagcgtg cgagctgaca cctactgtcg cctctactca ctgagtgtgg     1860

acaatttcaa cgaggtgctg gaggaatacc ccatgatgcg gcgtgccttt gagactgtgg     1920

ctattgaccg gctagatcgc ataggcaaga agaactccat cttgctgcac aaggttcagc     1980

atgatctcag ctcaggtgtg ttcaacaacc aggagaatgc catcatccag gagattgtca     2040

aatatgaccg tgagatggtg cagcaggcag agcttggcca gcgtgtgggg ctcttcccac     2100

caccgccacc accgcaggtc acatcggcca ttgccaccct acagcaggct gtggccatga     2160

gcttctgccc gcaggtggcc cgcccgctcg tggggcccct ggcgctaggc tccccacgcc     2220

tagtgcgccg cgcgccccca gggcctctgc ctcctgcagc ctcgccaggg ccacccgcag     2280

caagcccccc ggctgcaccc tcgagccctc gggcaccgcg gacctcaccc tacggtgtgc     2340

ctggctctcc ggcaacgcgt gtggggcccg cattgcccgc acgtcgcctg agccgcgcct     2400

cgcgcccact gtccgcctcg cagccctcgc tgccccatgg cgtgcccgcg cccagccccg     2460

cggcctctgc gcgcccggcc agcagctcca cgccgcgcct gggacccgca cccaccgccc     2520

ggaccgccgc gcccagtccg gaccgcaggg actcagcctc gccgggcgct gccagtggcc     2580

tcgacccact ggactctgcg cgctcgcgcc tctcttccaa cttgtgaccc ttgagcgccg     2640

ccccgcgggc cgggcggggc cgtcatccac accaaagcca tgcctcgcgc cgcccgcccg     2700

tgcccgtgca gaagccatag agggacgtag gtagcttagg aggcgggcgg ccctgcgccc     2760

ggctgtcccc ccatcgccct gcgcccaccc ccatcgcccc tgccccagcg gcggccgcac     2820

gggagaggga ggggtgcgat cacctcggtg cctcagcccc aacctgggac agggacaggg     2880

cggccctggc cgaggacctg gctgtgcccc gcatgtgcgg tggcctccga ggaagaatat     2940

ggatcaagtg caatactcgg cccgccggct tcccgctgcc cctggcaagc tcacgcaata     3000

accagcccgc ccctgcccac gcgtccgtgg tgacctccct cgggcaccca ggggcgggct     3060

tcacggccaa gccggcgtgg gggtgaggct gggtccccgc cgtcgccatg aatgtactga     3120

cgagccgagg cagcagtggc ccccacgccc cattaaccca caaccccatt ccgcgcaata     3180

aacgacagca ttggc                                                      3195


<210>  25
<211>  9685
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(9685)
<223>  Homo sapiens hyperpolarization activated cyclic nucleotide-gated 
       potassium channel 1 (HCN1)

<400>  25
ccgtcgccgg ccgcgtcctc cgggcatgga aggaggcggc aagcccaact cttcgtctaa       60

cagccgggac gatggcaaca gcgtcttccc cgccaaggcg tccgcgacgg gcgcggggcc      120

ggccgcggcc gagaagcgcc tgggcacccc gccggggggc ggcggggccg gcgcgaagga      180

gcacggcaac tccgtgtgct tcaaggtgga cggcggtggc ggcggtggcg gcggcggcgg      240

cggcggcgag gagccggcgg ggggcttcga agacgccgag gggccccggc ggcagtacgg      300

cttcatgcag aggcagttca cctccatgct gcagcccggg gtcaacaaat tctccctccg      360

catgtttggg agccagaagg cggtggaaaa ggagcaggaa agggttaaaa ctgcaggctt      420

ctggattatc cacccttaca gtgatttcag gttttactgg gatttaataa tgcttataat      480

gatggttgga aatctagtca tcataccagt tggaatcaca ttctttacag agcaaacaac      540

aacaccatgg attattttca atgtggcatc agatacagtt ttcctattgg acctgatcat      600

gaattttagg actgggactg tcaatgaaga cagttctgaa atcatcctgg accccaaagt      660

gatcaagatg aattatttaa aaagctggtt tgtggttgac ttcatctcat ccatcccagt      720

ggattatatc tttcttattg tagaaaaagg aatggattct gaagtttaca agacagccag      780

ggcacttcgc attgtgaggt ttacaaaaat tctcagtctc ttgcgtttat tacgactttc      840

aaggttaatt agatacatac atcaatggga agagatattc cacatgacat atgatctcgc      900

cagtgcagtg gtgagaattt ttaatctcat cggcatgatg ctgctcctgt gccactggga      960

tggttgtctt cagttcttag taccactact gcaggacttc ccaccagatt gctgggtgtc     1020

tttaaatgaa atggttaatg attcttgggg aaagcagtat tcatacgcac tcttcaaagc     1080

tatgagtcac atgctgtgca ttgggtatgg agcccaagcc ccagtcagca tgtctgacct     1140

ctggattacc atgctgagca tgatcgtcgg ggccacctgc tatgccatgt ttgtcggcca     1200

tgccaccgct ttaatccagt ctctggattc ttcgaggcgg cagtatcaag agaagtataa     1260

gcaagtggaa caatacatgt cattccataa gttaccagct gatatgcgtc agaagataca     1320

tgattactat gaacacagat accaaggcaa aatctttgat gaggaaaata ttctcaatga     1380

actcaatgat cctctgagag aggagatagt caacttcaac tgtcggaaac tggtggctac     1440

aatgccttta tttgctaatg cggatcctaa ttttgtgact gccatgctga gcaagttgag     1500

atttgaggtg tttcaacctg gagattatat catacgagaa ggagccgtgg gtaaaaaaat     1560

gtatttcatt caacacggtg ttgctggtgt cattacaaaa tccagtaaag aaatgaagct     1620

gacagatggc tcttactttg gagagatttg cctgctgacc aaaggacgtc gtactgccag     1680

tgttcgagct gatacatatt gtcgtcttta ctcactttcc gtggacaatt tcaacgaggt     1740

cctggaggaa tatccaatga tgaggagagc ctttgagaca gttgccattg accgactaga     1800

tcgaatagga aagaaaaatt caattcttct gcaaaagttc cagaaggatc tgaacactgg     1860

tgttttcaac aatcaggaga acgaaatcct caagcagatt gtgaaacatg acagggagat     1920

ggtgcaggca atcgctccca tcaattatcc tcaaatgaca accctgaatt ccacatcgtc     1980

tactacgacc ccgacctccc gcatgaggac acaatctcca ccggtgtaca cagcgaccag     2040

cctgtctcac agcaacctgc actcccccag tcccagcaca cagacccccc agccatcagc     2100

catcctgtca ccctgctcct acaccaccgc ggtctgcagc cctcctgtac agagccctct     2160

ggccgctcga actttccact atgcctcccc caccgcctcc cagctgtcac tcatgcaaca     2220

gcagccgcag cagcaggtac agcagtccca gccgccgcag actcagccac agcagccgtc     2280

cccgcagcca cagacacctg gcagctccac gccgaaaaat gaagtgcaca agagcacgca     2340

ggcgcttcac aacaccaacc tgacccggga agtcaggcca ctctccgcct cgcagccctc     2400

gctgccccat gaggtgtcca ctctgatttc cagacctcat cccactgtgg gcgagtccct     2460

ggcctccatc cctcaacccg tgacggcggt ccccggaacg ggccttcagg cagggggcag     2520

gagcactgtc ccgcagcgcg tcaccctctt ccgacagatg tcgtcgggag ccatcccccc     2580

gaaccgagga gtccctccag caccccctcc accagcagct gctcttccaa gagaatcttc     2640

ctcagtctta aacacagacc cagacgcaga aaagccacga tttgcttcaa atttatgatc     2700

cctgctgatt gtcaaagcag aaagaaatac tctcataaac tgagactata ctcagatctt     2760

attttattct atctcctgat agatccctct agcctactat gaagagatat tttagacagc     2820

tgtggcctac acgtgaaatg taaaaatata tatacatata ctataaaata tatatctaaa     2880

ttcccaagag agggtcaaaa gacctgttta gcattcagtg ttatatgtct tcctttcttt     2940

aaatcattaa aggatttaaa atgtcgttgt aagattattt atttctaacc tacttttact     3000

taagtccttt gatatgtata tttctctatt ttatgaagag ttcttggatt caatggaaac     3060

aaaactgatt ttaaaaaggc aactcaaatg aactagtaaa tagcaccaat caaaactttc     3120

tttcattagc tgtgtctctg catctaaatt gttaatcatt aatggtggag aattaaataa     3180

caaatcccat tttatagatc taaattgtat ttcggtgctt tcaatttcaa attaggttaa     3240

agaatgcact acttgcttgg ccaccgtagg agactagcat tgccactgtt tgttaagaat     3300

atcactaacc tcaaacatgt tcattgatct ttcagaaagc tgagggaaaa ttaatatttg     3360

tcttcatgtg ttatcggact tttaccaaga ctcgatcaat gttagttgta aataactttt     3420

tcaacccaaa taaaaatagc tattctgtgt tgtatgaagg taaaagtcat tgtttaagaa     3480

tttagtttta ttgcttcact tcaaaactta gagttttaaa ttttacaaaa cctgattgtg     3540

agaattattc aattgtaatg caatggcttg aaacctacaa tattatttta acctgcaatg     3600

ttttatgcaa aattgtatgc tcgaatctac aaattgcttg tattacacca aaaatcgtta     3660

cttttctttc ttcttgccat aatcaagcat ctgaaaatag tccctgcatg cttctgggga     3720

aaaaaaaata ggttcaaatc agtcattgta gagaaaggct tacagtattt ctcgtttcta     3780

gaaaagcata acaattcatt aattgcctat cttataattc ctataaggct gacttggatc     3840

tctgacttaa gtctagaagt gaggttttca cttttattta atattattgc tattattatt     3900

taaataatta tttgtaaacc acagcttgat ttggagttaa gtgttgtctg tgtcttcact     3960

gtagctggta atttactatg gtattaattt aaagaaataa attcaataca gcatcacgtc     4020

tgtttgggaa cacacatttt gctctatgta tattgtaact aaatggttag taaactttaa     4080

ggcatgtggt gactaacgta gcccttagat aggaggtttg tcatttttaa tgtgttgaaa     4140

atagtacaga catggtgaca gaaagcaggg gtaaagttga acgtctatga gcattgtctg     4200

tctgttttct taactcttta catgatctgt gagcacctgc ttcttctcaa agaactccct     4260

tagtaatcat ttgtgcctaa tgcatcccac acatgtggag tatgactgga acacaattga     4320

aagattccta acaactggct gcggtaaata acccaagtta agagcatgac ttaaagtgga     4380

ggtcttcagt atctctggca ctggcaatac atttaagaac atacagagat cacacattat     4440

gtgggacagg gcctgcagat agacttgagg acagaaaaca aaaacaaaag cagaaactct     4500

aaagtggatc cttgctgcct gttatgcctt ttgtggatat aatacctata ataccaaaat     4560

gagttgttat gtttaatttc aaacaaatcc caactggtgt ggaagtaatt aactgctagt     4620

cgatgtaatg taatcatcaa tatgctggtg acatatgatg gcatgtcagg aatactgttg     4680

taagaaaggg attgttcagt ctacctagaa cctatgggaa agctgcaaga ccatttacat     4740

atcagtacaa aactccttta ttttattaaa atatgagaat taacttcaat ttattaagat     4800

tacgtattgg tcctttaaat tattaaaggt ttacatttga taggattaat ggatttggta     4860

gtgaaatatt tttatatata taaatttttg gttttttatt ttgagcacta ttgggaaaca     4920

taagcaaaat tgaaatgcat ggtctttcag tgcaaccata caatttttat tcactttgta     4980

atagaatgga caaaaaaact aaggtttata tattaaacta ataaaaaggt acagggtaaa     5040

ttatatacat atatgtatga atgtatatat acttagatta agaaaaaaaa atgactcaca     5100

ttcctgtaat ataaaggtcc attgctagtt gaaaagtgac ctcttttctc tgtacatagt     5160

gaagcccgta tgtatggagt tttaatctgt acagaaagaa atgtattatt cattggtctt     5220

tctgctgctg gaaagataat agaatagctg attcttacaa caactgtatg atcagggatg     5280

agttagagta tttcttttgt ctttgctcaa agccatacat atataaatat atataaagat     5340

tattaataaa ttcaacaaaa aataaactac aatcatgaat attttatttt atcaatatat     5400

gctaatcaaa tgttttattt tattaatgag tacagctttg cctctatttt tacatcataa     5460

aatttccaag agcttatact tgataatcac ataaaatcaa ttatattcta taattctgga     5520

atgagaggac tttaaataga acatggattt ttcaaccact tctttgttta cctttttcgt     5580

atagtaaaat atgagcttat tttctttttt gctctgtgcc tttttagaat gtggttgttc     5640

tccaacttca aaacacaacc attttgtgta attattggat atacagatga gaaataattt     5700

tcctgtaata atggtaaata attgtcctgt aatatattta tacaaaccta ttttgttata     5760

atagttctat gacataccta ttttgttata atagttttat aacataccta ttttgttata     5820

atagggcctt gggctctatt ataacaaaac aggtttatat aaatacattc atatttatag     5880

ccttaaacaa aataggtttg tatagtaggc ccaaggccct attataacaa aataggtttg     5940

tataaatata ttcatattta tagccttggg ccctgcaaag ttatttggag agtgatagaa     6000

cctccccaca caagtgggtt ttaaatgata cctaaaagcc tgagatagag tttatcataa     6060

tgagaataag tagtgaagca ttcctgaaaa caaggaggat aaatagtagc aatggcaata     6120

tattctattc accaaaaaag tagcttgtct ccaggtctgg atgacctctt cataagtgaa     6180

caattccctg atgaatgctg ttccacttta aagagatggt tattttgcaa tttataaact     6240

taactgagca tactattttc aggacactac aaagtacata gtcaagttat taccgtcatt     6300

cctataggac agagaatgat ttaaacaata tgacatgttt aaaattttag atgatttatt     6360

tcaaatcctg aattatgtct acttcaaatt atgagcaatc tctattatct ttcaggacta     6420

tttaaaaaat ctccatacct cctctttcag cttaggtttt tatatttgtt aattttacta     6480

tgttactttg cttctatggc cctcacttgc actgtttata atgttaacct gtttgaatga     6540

gatatctctc cattatatct ttatcttttt agaacatgtg ccataaaacc catgtggtta     6600

ttttgttcat atgcactaca actagcaaac ttttatttta tgttcaccta ctttaaaaag     6660

tactcatact gtaccatggg aaagaaacat gggccttata gaatggaatg ctgagctatt     6720

ttgagtcctg aaaacaatgg ccaaaaattt aaggaactgt ggttgctgca tgcaccaaat     6780

tgtagcacat acaaataaat aaaatacagt tctataactg tattcaatat ggttattttc     6840

aaggaaaaat aggatagaaa ttttctttga aagatttgct attgtactta gggaagtaca     6900

cctgctatta cccctcaaaa gcaatgactt tcttaagcaa tttcaatttt tttccttttt     6960

aacaaccctg cacttgcaca accctgcatc tcttgtctca ccctaatgct gaccctgctt     7020

ccaattcagg ctttgacagg gacaaatgga gattttaagg ttttttaatg agagaagcct     7080

tgctgacact ccccgcatcc caccttgaaa attatttaaa gatgatctta aaagaaccta     7140

cagataatgc tctgaatttg tttacaaggt ccttgatgtg gagagaatga gtaatacatt     7200

aaatgctggg gaaataatta tcatttagtg aaaaattaag catgcttttc taaaatgtgg     7260

atgtttaaca gagcacagct gattgggaac actggcagtt caatgcagct ggagtgtctc     7320

acagggtgaa gaggaaccca gatcaagtgg gaaataggga tttcaaaaac cttctgaaag     7380

gcttttaaca tcagggcaaa ggttttacag tgttgtactt tatattctta atttaagctt     7440

atcaacgggg aggattcaca ttgaaatgtc tgttttgcta atgtaacaag gaataaaata     7500

atttatgaca cagcaaaaac tgggggctat ttacaacccc accctgcctt gtgaggatgc     7560

tgggtcctaa ggaaggtcct aggtttgcta aatagagtaa tgggaatagg aaactgaaag     7620

tttacttgct ttgcgtaaga taatatattg cggcagggaa ggggtacaag aagataagag     7680

ctagaacctg tgagaaggga aagaagtgat aaaataattt tggctaaaat aaagcaagtt     7740

ctcaggccag gcgtggtggc tcatgcctgt aatcctagca ctttgggagg ccaaagtggg     7800

aggaatgctt gaggccagga attggagacc aaccagggca gcatgtcaag acctggtctc     7860

tacaaggaaa aaaaattttt ttaattgacc agtatatact tacatacctg cagtgtttag     7920

aaaacccgac tataggtggt gtattcctgt agtcctagtt actcagaaag ttaaggcagg     7980

aggatcgctt gaacttagga ggtcaaggct gcagtgagcc ctgttcgttc cactgcactc     8040

cagcttgggg gacagagcaa aaccctttct caagaaaaac ccaaacaaac aaaaaagtga     8100

agccagttct ttaatttcta ttggagatat cacacacgct ccaaagagtg gcaaaggtga     8160

acattctttg gagctattat atttctaatg taacatcaat ggccatttac tcccaaaggg     8220

aaacatcttt tttttttttt ttttttaaga tggagtctgg ctctgtcacc caggtgggag     8280

tgcaatggca ggatcttggc ccactgcaac atcagcctcc caggtttaag caattctcct     8340

gcatcagcct ccagagtagc tgggattaca ggtgcccgcc accatggcta gctaaatttt     8400

tgtaattttt agtagagaca gggttttacc atgttggcca ggccggtctc gaacccctaa     8460

cctcaagtga tccgcccgcc tcaccctcca gaagtgctag gattacaggc ctgagccacc     8520

gcacccggcc ctgctatttt tttctatgta gttgtttcag taataccata tgagcagaga     8580

atactattga ttcattcaat tgaagaaatc tgaataaatt agtaaatata ataattcttc     8640

aaaagaggac cactttatgt ttccaataga ttatataatt gaattcaggt aacgtagagt     8700

tattcagact ttttttttta aataacggaa ttttgcaaaa aaacaggttg catcgttttc     8760

tacagagaat attcagatgt gtagaggcaa agagactttc ttgaaaggtt tttatttcct     8820

gttaaatttg tgaggaaaac tcctgagaaa ggaaagattt acttttgaag gaagaaagaa     8880

cataacccaa agaaatttga aagattcaaa aagagttttc caaatgtatt ctcatttctt     8940

tctcatattt gttcaaggtc ttagtttcca agcattcaaa attaaatctt gtttgcctaa     9000

ctcttctaac atctattacc aacctaacat attacaattc tgtttaaaat gtgcagttct     9060

aaatgttctt gcgtgcctca ctgtggaaag tgtggtgcat ggaactgcag cgtcagtatc     9120

acccagaagt ataattacaa gaagtgcaga gtccttggcc ttaccctgta cctacagaag     9180

tccgcttttg ggcaagatcc ccagatgatt catatgtgta ttaatattga aaaaattgga     9240

actagtaagt cctagaggag gtaaatttta agggcttttt aagggaactt ccaagtgtga     9300

agacatttct ggagatgaca agtcaacata gcatgggatc ttggctagac aaggaaagcg     9360

agagaacatt aaataaacac aagcaacgac aaaccaccta tgttataatt ttatcctgga     9420

ccatccaaag tttactcttg gtcacgctgt ctaacccagc ctgcctcctg gcacttgcta     9480

gttagaacca gggaagagaa aactaatatg tgttaggtat tataatttcc ttatgtcaca     9540

taaattttgg tgccatagct agcaatgttt cttaatatca catcagtaca atgtgtccat     9600

tgccttctgt aacattttta atgctatcaa taatacattg acattataaa aataaatgaa     9660

tgtggtcaaa aaaaaaaaaa aaaaa                                           9685


<210>  26
<211>  7911
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(7911)
<223>  Mus musculus hyperpolarization-activated, cyclic nucleotide-gated
       K+ 1 (Hcn1)

<400>  26
aatgtcacgc tgggcagaag tggcacaggc gagcggcggg gcgcgcgcgg gtagaggcgg       60

tctgcggcca gcagggggca gccgaggggc ggcgctggcg cgcgggtgcc gagcggagga      120

gcctcgcccc gcgcccgcag cctcagcctc agcctcagta ccaggcgcgg cggagcccgg      180

agcgcggcag agccggcagc gcagccactg agggcagcgg cggcggcggg agccaggcgc      240

gcagcggagc agcgggcggg cgggaagcag tagccgccgc cgccgctgcc gccgcgacgg      300

gcagccggct ccggcccctg ctccttggct tcgagccccc ggcgagtctg gagcccgcgc      360

cgtcgccggt cgcgtcctcc gggcatggaa ggcggcggca aacccaactc cgcgtccaac      420

agccgcgacg atggcaacag cgtcttcccc tccaaggcgc ccgcgacggg gccggtggcg      480

gccgacaagc gcctggggac cccgccgggg ggcggcgcgg ccgggaagga acatggcaac      540

tccgtgtgct tcaaggtgga cggcggcgga ggagaggagc cggcgggcag cttcgaggat      600

gccgaggggc cccggcggca gtatggtttc atgcagaggc agttcacctc catgctgcag      660

cctggggtca acaaattctc cctccgcatg tttgggagcc agaaggcggt ggagaaggag      720

caggaaaggg ttaaaactgc aggcttctgg attatccatc cgtacagtga cttcaggttt      780

tattgggatt taatcatgct tataatgatg gttggaaatt tggtcatcat accagttgga      840

atcacgttct tcacagagca gacgacaaca ccgtggatta ttttcaacgt ggcatccgat      900

actgttttcc tgttggactt aatcatgaat tttaggactg ggactgtcaa tgaagacagc      960

tcggaaatca tcctggaccc taaagtgatc aagatgaatt atttaaaaag ctggtttgtg     1020

gtggacttca tctcatcgat cccggtggat tatatctttc tcattgtaga gaaagggatg     1080

gactcagaag tttacaagac agccagagca cttcgtatcg tgaggtttac aaaaattctc     1140

agtctcttgc ggttattacg cctttcaagg ttaatcagat acatacacca gtgggaagag     1200

atattccaca tgacctatga cctcgccagt gctgtggtga ggatcttcaa cctcattggc     1260

atgatgctgc ttctgtgcca ctgggatggc tgtcttcagt tcctggttcc cctgctgcag     1320

gacttcccac cagattgctg ggtttctctg aatgaaatgg ttaatgattc ctggggaaaa     1380

caatattcct acgcactctt caaagctatg agtcacatgc tgtgcattgg ttatggcgcc     1440

caagcccctg tcagcatgtc tgacctctgg attaccatgc tgagcatgat tgtgggcgcc     1500

acctgctacg caatgtttgt tggccatgcc acagctttga tccagtcttt ggactcttca     1560

aggaggcagt atcaagagaa gtataagcaa gtagagcaat acatgtcatt ccacaagtta     1620

ccagctgaca tgcgccagaa gatacatgat tactatgagc accgatacca aggcaagatc     1680

ttcgatgaag aaaatattct cagtgagctt aatgatcctc tgagagagga aatagtcaac     1740

ttcaactgcc ggaaactggt ggcaactatg cctctttttg ctaacgccga tcccaatttc     1800

gtgacggcca tgctgagcaa gctgagattt gaggtgttcc agcccggaga ctatatcatt     1860

cgagaaggag ctgtggggaa gaaaatgtat ttcatccagc acggtgttgc tggcgttatc     1920

accaagtcca gtaaagaaat gaagctgaca gatggctctt acttcggaga gatatgcctg     1980

ctgaccaagg gccggcgcac tgccagtgtc cgagctgata cctactgtcg tctttactcc     2040

ctttcggtgg acaatttcaa tgaggtcttg gaggaatatc caatgatgag aagagccttt     2100

gagacagttg ctattgaccg actcgatcgg ataggcaaga aaaactctat tctcctgcag     2160

aagttccaga aggatctaaa cactggtgtt ttcaacaacc aggagaacga gatcctgaag     2220

cagatcgtga agcatgaccg agagatggta caagctatcc ctccaatcaa ctatcctcaa     2280

atgacagccc tcaactgcac atcttcaacc accaccccaa cctcccgcat gaggacccaa     2340

tctccgccag tctacaccgc aaccagcctg tctcacagca atctgcactc acccagtccc     2400

agcacacaga cgccccaacc ctcagccatc ctttcaccct gctcctatac cacagcagtc     2460

tgcagtcctc ctatacagag ccccctggcc acacgaactt tccattatgc ctctcccact     2520

gcgtcccagc tgtcactcat gcagcagcct cagcagcaac taccgcagtc ccaggtacag     2580

cagactcaga ctcagactca gcagcagcag cagcaacagc agcagcagca gcagcagcaa     2640

cagcaacaac agcagcagca gcagcagcag cagcagcagc agcagcagca gcagcagcag     2700

cagcagcagc cacagacacc tggtagctcc acaccgaaaa atgaagtgca caagagcaca     2760

caagcccttc ataacaccaa cctgaccaaa gaagtcaggc ccctttccgc ctcgcagcct     2820

tctctgcccc atgaggtctc cactttgatc tccagacctc atcccactgt gggcgaatcc     2880

ctggcctcta tccctcaacc cgtggcagca gtccacagca ctggccttca ggcagggagc     2940

aggagcacag tgccacaacg tgtcaccttg ttccgacaga tgtcctcggg agccatcccc     3000

cccaaccgag gagtgcctcc agcaccccct ccaccagcag ctgtgcagag agagtctccc     3060

tcagtcctaa atacagaccc agatgcagaa aaaccccgtt ttgcttcgaa tttatgattc     3120

ttgatgattg tcaaagcaga aaagaagtac tctaataaac agaatattct cagatattat     3180

tttattctat ctcacgatag atccctatag cctactctga aaaaaaaata ttttagaagc     3240

tgtggcctac atgcaaatgt aaaaacatat atacatatat aattaaatat atatatatat     3300

atatatatct aaatgcccaa gagaagttca aaagacttgt ataacattca gtgttacatg     3360

tcttcctctc tttaaaacca ttaaaggatt taacacattg ttgtaaggtc attgatttct     3420

aaccttttac ttgattcctt tgatatatgt gtttctccct tttatgaaga gttcttggag     3480

tcaatggaaa caaaactctt gattttaaaa aaggcaactc caattagatc cagcatagca     3540

ccaatcaaag ctttctttca ttagctgtgc ctctgcgtct aggttgttaa ttatgcggga     3600

ttcaataaac aaatcccagt ttatagctct caattgtatt ttggtgcttt aaattttgag     3660

ttaggtgaag gaacacgctc catgctcagc caccgtagga gactaacatt gccattaagg     3720

cttcctctaa cctcaaacat gttcattgat tttgtgagaa aagtgaggag atatttgtct     3780

tcatgtgtca ctggactttt accaagacgc agtcaatgtt agctgtaaat aactttccca     3840

gcccgaatta aagtaactat tctgtgttgt agaaaggtaa aagtcagtgt ttaagaattt     3900

agttttactg cttcacttca aaagttagag ttttaaattt cacaaaacac tctaattgtg     3960

acagctgttc aaatgtaatg caatggcttg agacctacaa tatcattttt aacctgcgat     4020

actttaatgc aaaaattgta tgcttgaacc tacaaattgc ttgtatgaca ccaaaaatca     4080

ttacttttat tccttcttga cataatcaag cacctgaacc tggtcctggc atgctttcgg     4140

gggcaaaaaa aaataaaata aaataactta aaaaaaaaag tagattcaaa tcaatcattg     4200

taagaaaagg ctgacagtat ttctcacttc tagatgagta taactattca ttaattgcct     4260

ctcttaaaat tcttaaaagg ctgacttgga tctctgactt aaatctagaa gtgaggtttt     4320

cactttcatt tgatattgtt gctgttctta ttgtttaagc aatcatttgc aaaccatagc     4380

ttgttttgga gttaaaggtg ttatgtgtct tcatgttagt tggtagttta ttgtgatgtt     4440

aatgtgaaga aataaatact atatatcacc acatctgttt ggaaatacac attttgccct     4500

ttgtatattg taactaagca gttagtaaat cttaaggcat gtggtaacct acatagtcct     4560

tagatagaca ggaggtttgt tctttcaaat gtgctgaaac ttatatggac tccgtgaggg     4620

gaagcagggg ggaattgagc tgtctgaaag cattgtctgt ttgttcactt gtttccttaa     4680

ttctttctgt gagcatcatg gagcctaatc tagggaagtc ccttagcgat cttgcttcat     4740

gtgtgtttgc tgcacctcac acaagtggtg ggtgagtaga acacagtagc aggctctcta     4800

gtgcctgact tctgtacgta actcaagaga gtgagctgat atggaggtct ttgacattac     4860

aggcacaaat gatctattta agaacataaa gaccatacat tctattggga cagggcctcc     4920

aggtatcctt gaggaccaag aacaaaagta gaagcaagag gtttaaagtg gatctacatt     4980

gccttttatg aaaccaaaat gagtcgttgc acttaattgc taacggatcc taccttgtgt     5040

gaaacaatca gcaatgctag gtaacgtgat gtcattcctg taatgctagt gaccaatggt     5100

atcctgttag gaatgatgta agagagagat cctgcagcct acgtaaaatc tatgggaaag     5160

ttgcaagacc tatcacatat cagtacaaaa ctcctttatt ttattaaatt taaaaattag     5220

cttcttgtta agatcatgta ctagtccttt aaattattaa aggtctacct ttggcaggat     5280

taatgcattt cgtagtaaaa tatttttata tatcaatttt ttgagcacta ttggagaaca     5340

tccgcaaaat tgaattgcat ggttattcag tgcaaccaat aaaattttta ttcactttgt     5400

actcgaatgg acaaagaaca ctaaggttta tatgttaaag taacaaaacc atacagggta     5460

tattaaatac acatatgtat gaatgtgtgt gtttgtaaag gtacagtgct aggagaacat     5520

gacctttttt ctctgtacat agttaagctc aagtacggag ttttaatctg tacgggaaga     5580

gctgtattgg ggtcttttac tgctgagaaa gtagaacaat aacttatact ttgcactgta     5640

tgaccaggga agagttagag tatttctttt gtctttgctc aaagccatac atatataaat     5700

atatattaag attattaata aattcaaaag aaaataaacc aaattatgaa tattttattt     5760

tgttgttgaa atctaatcaa atgtttaact cattgaggag tacagatttg cttgttgttc     5820

tctctttgta taatctccaa aaagatttgt ttttgaaaat caccatacaa ttgttataga     5880

aattctacag atatagaatg aatgtaattt aaatagaaca tagatgtctc agtcacctgt     5940

ttgttttcct ttttttcata tggtaacatt tggttatctt attctttacc ccatgcctct     6000

ttagtatgtg gtgtttctcc agttttaaaa tgcagccatg tctttgttat tggatatggg     6060

gatggttttt aattttcgta catgacctgt tttctctggg cttttcaaag gcctcagatg     6120

agatttgtca caatgaggat aaatagcaaa gcagtcctaa acacaaggag gataaagtgt     6180

gattcttcaa ttggttgtcc tcctcaaaca cacagcctga ctccagatct ccgtgacctc     6240

tccataagtg aatggttacc aagtggatgc cattctactt ttaaaagatg cttactctat     6300

catttacaga cttaaatgaa catgttattt taaggacact gcaaagaaag cagtcgctag     6360

tctaataatt cctacacata cgaacaattt aaacaatatg atgagtttca acttttagat     6420

acattatact aaaatcagaa ttagttatga ttcaacatat aagtcacctt gactccttga     6480

caagattatt gtgtaaaata cctccatata tttttatgac ttgtttttta tttggtaagt     6540

ttactataat tgctatttgg gatcttactt tccttatttt tataatatta aactagatga     6600

ctaaaatttt tctcattttt atcttctcca tccttgtaga gcttgtatca tgccatgcaa     6660

gtgtaggata tgttgttgtt gctgctacag ctgctgctat tgttgttaat attcactaac     6720

cctaacaaaa attttctata tgataggtat atctacctaa atatccataa gtctgtgcca     6780

taagaaaaaa actatactca agtattaaac tacactgaat tctgaatagt caaaaattgt     6840

cacgaaacat gcagttgaat atgtggacca aattatgtgg gaattttttt aactttattc     6900

aaaatagttc ctgaaatatt ttcaaaatca tgttggaaat tttctttcga ggattttttt     6960

tttttatcaa tttaagggtg atttgtagtt gctgtgacca cttgaaaata gtgactttct     7020

aaagcagttt tatttcattt taataaataa cacgttttta ttcttttctc atatatttat     7080

tctgatacaa ttttcccaac cccctcttcc cccagcctct tccctccccc atcaccactc     7140

tcttccatat ccccacccct ctcctgggga aaaggatcga catttttatt gcatgtattg     7200

atatcttcac aaacaggtca ttttggcctt gatcacattt atagctttca ggtaaaaaca     7260

aaaaacaaaa aacaaaacca taagcttctc catatagcaa aaatattcag gttgaataat     7320

aaatctgtca ccacaataaa tcctctcatt ctagttcaaa ggatacgtct gtgatatttg     7380

ctctgttgct taatgctttg tgcagctctc tcgatgaaat gttattacta tcttttcttc     7440

atatggaaat agtctctgta acacaaggtg atgaggaatg aagataaatt tccaaaaaaa     7500

aaaaaaatct ggaatgagat aaatggtata tttgttccat gtacaaatgt tgatgtctca     7560

aaacaagaca agtgatgttt tataaaatca aaataagtgt gatggccata acccaagtat     7620

tccattttaa attaagacgg gacccaaccc cgcaatcacg tgaacatgcc tctcttatct     7680

caccatgcct ctcttatctc accataatcc taccccagtt tccctaacca agggcggtgc     7740

atagcgacaa gtgaagactg gaaagacttt gttgaaagaa gccttgccaa gacttggttt     7800

tggcctatca tgagacttgt taaagatgat aataaaggga aatgtatgga agtctattaa     7860

tttatgtctg agatacttga tgtagaaaga ataaaatttg aagaaagcac c              7911


<210>  27
<211>  7245
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(7245)
<223>  Homo sapiens hyperpolarization activated cyclic nucleotide-gated 
       potassium channel 4 (HCN4)

<400>  27
caaaaatgcc agggaaaggc gagcccagag cttggtgatg gagaaattgg gaagccaccc       60

cccacccttc aatcttagga tggggaattc gcaactgaag ccggagcttc agacttgggg      120

cgcactccca gcttagccca ggaaagagat ttaagggcgc agcagtgtgg atacctctca      180

ccccggcccc gaaggtctag cgagggtcta acctgggccc cttgccaggc ccgccccccg      240

cccctttcca gcccccggcc cgtgcgccgc tgccccttta agaagcccag gtaggcaggc      300

ccggctgctg gagccgctcc tatggcaacc cgcgagctgc ggcggcttca tgaatattcc      360

ggggcgcggg agcccgagcg ctgccggagg gcgcttcggg ggaggcggcc gctgatgtaa      420

gcccggcggg tcgctgggct ccgctcggtt gcggcgggag ccccgggacg ggccggacgg      480

gccggggcag aggaggcgag gcgagctcgc gggtggccag ccacaaagcc cgggcggcga      540

gacagacgga cagccagccc tcccgcggga cgcacgcccg ggacccgcgc gggccgtgcg      600

ctctgcactc cggagcggtt ccctgagcgc cgcggccgca gagcctctcc ggccggcgcc      660

cattgttccc cgcgggggcg gggcgcctgg agccgggcgg cgcgccgcgc ccctgaacgc      720

cagagggagg gagggaggca agaagggagc gcggggtccc cgcgcccagc cgggcccggg      780

aggaggtgta gcgcggcgag cccggggact cggagcggga ctaggatcct ccccgcggcg      840

cgcagcctgc ccaagcatgg gcgcctgagg ctgcccccac gccggcggca aaggacgcgt      900

ccccacgggc ggactgaccg gcgggcggac ctggagcccg tccgcggcgc cgcgctcctg      960

cccccggccc ggtccgaccc cggcccctgg cgccatggac aagctgccgc cgtccatgcg     1020

caagcggctc tacagcctcc cgcagcaggt gggggccaag gcgtggatca tggacgagga     1080

agaggacgcc gaggaggagg gggccggggg ccgccaagac cccagccgca ggagcatccg     1140

gctgcggcca ctgccctcgc cctccccctc ggcggccgcg ggtggcacgg agtcccggag     1200

ctcggccctc ggggcagcgg acagcgaagg gccggcccgc ggcgcgggca agtccagcac     1260

gaacggcgac tgcaggcgct tccgcgggag cctggcctcg ctgggcagcc ggggcggcgg     1320

cagcggcggc acggggagcg gcagcagtca cggacacctg catgactccg cggaggagcg     1380

gcggctcatc gccgagggcg acgcgtcccc cggcgaggac aggacgcccc caggcctggc     1440

ggccgagccc gagcgccccg gcgcctcggc gcagcccgca gcctcgccgc cgccgcccca     1500

gcagccaccg cagccggcct ccgcctcctg cgagcagccc tcggtggaca ccgctatcaa     1560

agtggaggga ggcgcggctg ccggcgacca gatcctcccg gaggccgagg tgcgcctggg     1620

ccaggccggc ttcatgcagc gccagttcgg ggccatgctc caacccgggg tcaacaaatt     1680

ctccctaagg atgttcggca gccagaaagc cgtggagcgc gaacaggaga gggtcaagtc     1740

ggccggattt tggattatcc acccctacag tgacttcaga ttttactggg acctgaccat     1800

gctgctgctg atggtgggaa acctgattat cattcctgtg ggcatcacct tcttcaagga     1860

tgagaacacc acaccctgga ttgtcttcaa tgtggtgtca gacacattct tcctcatcga     1920

cttggtcctc aacttccgca cagggatcgt ggtggaggac aacacagaga tcatcctgga     1980

cccgcagcgg attaaaatga agtacctgaa aagctggttc atggtagatt tcatttcctc     2040

catccccgtg gactacatct tcctcattgt ggagacacgc atcgactcgg aggtctacaa     2100

gactgcccgg gccctgcgca ttgtccgctt cacgaagatc ctcagcctct tacgcctgtt     2160

acgcctctcc cgcctcattc gatatattca ccagtgggaa gagatcttcc acatgaccta     2220

cgacctggcc agcgccgtgg tgcgcatcgt gaacctcatc ggcatgatgc tcctgctctg     2280

ccactgggac ggctgcctgc agttcctggt acccatgcta caggacttcc ctgacgactg     2340

ctgggtgtcc atcaacaaca tggtgaacaa ctcctggggg aagcagtact cctacgcgct     2400

cttcaaggcc atgagccaca tgctgtgcat cggctacggg cggcaggcgc ccgtgggcat     2460

gtccgacgtc tggctcacca tgctcagcat gatcgtgggt gccacctgct acgccatgtt     2520

cattggccac gccactgccc tcatccagtc cctggactcc tcccggcgcc agtaccagga     2580

aaagtacaag caggtggagc agtacatgtc ctttcacaag ctcccgcccg acacccggca     2640

gcgcatccac gactactacg agcaccgcta ccagggcaag atgttcgacg aggagagcat     2700

cctgggcgag ctaagcgagc ccctgcggga ggagatcatc aactttaact gtcggaagct     2760

ggtggcctcc atgccactgt ttgccaatgc ggaccccaac ttcgtgacgt ccatgctgac     2820

caagctgcgt ttcgaggtct tccagcctgg ggactacatc atccgggaag gcaccattgg     2880

caagaagatg tacttcatcc agcatggcgt ggtcagcgtg ctcaccaagg gcaacaagga     2940

gaccaagctg gccgacggct cctactttgg agagatctgc ctgctgaccc ggggccggcg     3000

cacagccagc gtgagggccg acacctactg ccgcctctac tcgctgagcg tggacaactt     3060

caatgaggtg ctggaggagt accccatgat gcgaagggcc ttcgagaccg tggcgctgga     3120

ccgcctggac cgcattggca agaagaactc catcctcctc cacaaagtcc agcacgacct     3180

caactccggc gtcttcaact accaggagaa tgagatcatc cagcagattg tgcagcatga     3240

ccgggagatg gcccactgcg cgcaccgcgt ccaggctgct gcctctgcca ccccaacccc     3300

cacgcccgtc atctggaccc cgctgatcca ggcaccactg caggctgccg ctgccaccac     3360

ttctgtggcc atagccctca cccaccaccc tcgcctgcct gctgccatct tccgccctcc     3420

cccaggatct gggctgggca acctcggtgc cgggcagacg ccaaggcacc tgaaacggct     3480

gcagtccctg atcccttctg cgctgggctc cgcctcgccc gccagcagcc cgtcccaggt     3540

ggacacaccg tcttcatcct ccttccacat ccaacagctg gctggattct ctgcccccgc     3600

tggactgagc ccactcctgc cctcatccag ctcctcccca ccccccgggg cctgtggctc     3660

cccctcggct cccacaccat cagctggcgt agccgccacc accatagccg ggtttggcca     3720

cttccacaag gcgctgggtg gctccctgtc ctcctccgac tctcccctgc tcaccccgct     3780

gcagccaggc gcccgctccc cgcaggctgc ccagccatct cccgcgccac ccggggcccg     3840

gggaggcctg ggactcccgg agcacttcct gccaccccca ccctcatcca gatccccgtc     3900

atctagcccc gggcagctgg gccagcctcc cggggagttg tccctaggtc tggccactgg     3960

cccactgagc acgccagaga cacccccacg gcagcctgag ccgccgtccc ttgtggcagg     4020

ggcctctggg ggggcttccc ctgtaggctt tactccccga ggaggtctca gcccccctgg     4080

ccacagccca ggccccccaa gaaccttccc gagtgccccg ccccgggcct ctggctccca     4140

cggatccttg ctcctgccac ctgcatccag ccccccacca ccccaggtcc cccagcgccg     4200

gggcacaccc ccgctcaccc ccggccgcct cacccaggac ctcaagctca tctccgcgtc     4260

tcagccagcc ctgcctcagg acggggcgca gactctccgc agagcctccc cgcactcctc     4320

aggggagtcc atggctgcct tcccgctctt ccccagggct gggggtggca gcgggggcag     4380

tgggagcagc gggggcctcg gtccccctgg gaggccctat ggtgccatcc ccggccagca     4440

cgtcactctg cctcggaaga catcctcagg ttctttgcca ccccctctgt ctttgtttgg     4500

ggcaagagcc acctcttctg gggggccccc tctgactgct ggaccccaga gggaacctgg     4560

ggccaggcct gagccagtgc gctccaaact gccatccaat ctatgagctg ggcccttcct     4620

tccctcttct ttcttctttt ctctcccttc cttcttcctt caggtttaac tgtgattagg     4680

agatatacca ataacagtaa taattattta aaaaaccaca cacaccagaa aaacaaaaga     4740

cagcagaaaa taaccaggta ttcttagagc tatagatttt tggtcacttg cttttataga     4800

ctattttaat actcagcact agagggaggg agggggaggg aggagggagc aggcaggtcc     4860

caaatgcaaa agccagagaa aggcagatgg ggtctccggg gctgggcagg ggtgggagtg     4920

gccagtgttg gcggttctta gagcagatgt gtcattgtgt tcatttagag aaacagctgc     4980

catcagcccg ttagctgtaa cttggagctc cactctgccc ccagaaaggg gctgccctgg     5040

ggtgtgccct ggggagcctc agaagcctgc gaccttggga gaaaagggcc agggccctga     5100

gggcctagca ttttttctac tgtaaacgta gcaagatctg tatatgaata tgtatatgta     5160

tatgtatgta agatgtgtat atgtatagct atgtagcgct ctgtagagcc atgtagatag     5220

ccactcacat gtgcgcacac gtgtgcggtc tagtttaatc ccatgttgac aggatgccca     5280

ggtcacctta cacccagcaa cccgccttgg cccacaggct gtgcactgca tggtctaggg     5340

acgttctctc tccagtcctc agggaagagg accccaggac ttcgcagcag gccccctctc     5400

tccccatctc tggtctcaaa gccagtccca gcctgacctc tcaccacacg gaagtggaag     5460

actccccttt cctagggcct caagcacaca ccgccacctc tggggccgtc agtttgccca     5520

tctgtacagt gggaggtgag cggaacttct gtttattgag tctgctctgt gccaagcact     5580

ggtttcgcac tttacacaca ttaactcctt cagtttcaca aagaccatgg ggtgggtact     5640

ttgattctcc ccatttagca gaggaagaaa cagttttggg taatttttcc agaatcatgt     5700

aactaggagt ggcagagtgg ggactgattt gaggttcgag tccacgcctc cttgaggccc     5760

aagtctgtgt tccttccatc agaaaactgt gttgaggggg gctgaggtag atggtcccca     5820

agcatggtac agaaggaaga caccagattt tggcagcagt caggcctggg tttgaatccc     5880

agccctgcca cttcttagct gtatgatctt gggcaagtta tctgaccttt ctgtcacctc     5940

atttgtaaaa tgggaataat tatggtactg cctcacaagg acctatgagg accagatgag     6000

aaaaatctat atgtgaaatg cccagcccag cgcctggcac ataccatggt aggtgctcaa     6060

taaaaaatca catttcttct gcccctcata tgcccagcct attgctccag caaactatgt     6120

gagagcccag ggagctttgg ctgagggctc caagacttaa aatctcagga ctcaggaggt     6180

ggctgggcct ccctaagggc ccaaggaagg tgtgtggcca gaggtgggtg ggagccaggc     6240

cttgagaagt gggaagactt caacagggag agagggaggg aatggtgggt gggatggagt     6300

gtatggtggg gagattcctg aggtggatgt ggagtggtgg atcagggctt tgggagggga     6360

tccccaggct gaggggtcag agggacggcc ttgggtgata gggtaaggga ttgtctgggc     6420

ttagtcctgg caactaggag ccataagcag gttccagatt gcgggaacga gaaagcagct     6480

cagatgcctt tggaggcacc atcctccctc ctcccagatg ggatcttgcc agagccaagg     6540

tcaggggtct gcccctgcct atagggccag agcaggtatg gctgcaatcc ccaagtaatg     6600

agaagggctg gtcccacatt atccatccag aaccttccat gctccaagcc agaatgttgg     6660

caagatcggg ttttgccttg agctatcctg ggatgtgaga caaaccgatt tctccataga     6720

tgggctgcag ggagtgggag gcagtactcc aggagagaag tgggtgaagg ttcctgggat     6780

cttaggtaaa gactagacgc cgcctagtac tggtctctac tgtgctggct caggagttct     6840

gagaactgga aggacttagc ctcaacctga gttctgcaca caccccttcc ccttaaggaa     6900

ggcagctctg agaggcagca ggacttgatc caaacccaca gtcttgtcct ggaggcagca     6960

ggggtgaagg tggagggtcc agggccatga ggagccccct tgccatcaga gcctggccta     7020

accaccctct tctctactta cacacacatg cattttataa tagctctgac ccaacctggc     7080

cactctgcag agactgggac agacaggtgc aggcaatggg ccctcccaca cccagtcacc     7140

tacaaggaat tttcaaatcc acttttaaaa cagaaaccgg taaatgcgcc gtattgtata     7200

ttttatttaa ataaaaaaaa ttccagcaaa aaaaaaaaaa aaaaa                     7245


<210>  28
<211>  3798
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(3798)
<223>  Mus musculus hyperpolarization-activated, cyclic nucleotide-gated
       K+ 4 (Hcn4)

<400>  28
atggacaagc tgccgccgtc catgcgcaag cggctctaca gccttccgca gcaggtgggg       60

gccaaggcgt ggatcatgga cgaggaagag gatggtgagg aagaaggggc cgggggccgc      120

caggacccca gccgaaggag catccggctg cggccgctgc cctcgccctc tccctcggtg      180

gctgcgggct gctcggagtc ccggggtgcg gccctcgggg cgacagagag cgaggggccg      240

ggccgcagcg ccggcaagtc cagcaccaac ggtgactgca ggcgcttccg cgggagtctg      300

gcctcgctgg gcagccgggg cggcggcagt ggtggagcag ggggcggcag cagtctcggg      360

cacctgcatg actccgcgga ggaacggcgg ctcatcgccg ctgagggcga tgcgtccccc      420

ggcgaggaca ggacgccccc gggcctggcg accgaacccg agcgcccggc caccgcggca      480

caacccgcag cctcgccgcc gccccagcag ccgccgcagc cggcctctgc ctcctgcgag      540

cagccctcgg cggacaccgc tatcaaagtg gagggaggcg cggccgccag cgaccagatc      600

ctccccgagg ccgaggtgcg cctgggccag agcggcttca tgcagcgcca gttcggtgcc      660

atgctgcaac ctggggtcaa caaattctcc ctaaggatgt tcggcagcca gaaagcggtg      720

gagcgcgagc aggagagggt taagtcagca gggttttgga ttatccaccc ctacagtgac      780

ttcagatttt actgggacct gacgatgctg ttgctgatgg tggggaatct gatcatcata      840

cccgtgggca tcaccttctt caaggatgag aacaccacac cctggatcgt cttcaatgtg      900

gtgtcagaca cattcttcct cattgacttg gtcctcaact tccgcacggg gatcgtggtg      960

gaggacaaca cagaaatcat ccttgacccg cagaggatca agatgaagta cctgaaaagc     1020

tggtttgtgg tagatttcat ctcctccatc cctgtcgact acatcttcct tatagtggag     1080

actcgcattg actcggaggt ctacaaaacc gctagggctc tgcgcattgt ccgtttcact     1140

aagatcctca gcctcctgcg cctcttgagg ctttcccgcc tcattcgata cattcatcag     1200

tgggaagaga tcttccacat gacctatgac ctggccagcg ccgtggtacg catcgtgaac     1260

ctcattggca tgatgcttct gctgtgtcac tgggatggct gcctgcagtt cctagtgccc     1320

atgctgcagg acttccccca tgactgctgg gtgtccatca atggcatggt gaataactcc     1380

tgggggaagc agtattccta cgccctcttc aaggccatga gccacatgct gtgcattggg     1440

tatggacggc aggcacccgt aggcatgtct gacgtctggc tcaccatgct cagcatgatc     1500

gtgggggcca cctgctatgc catgttcatc ggccacgcca ctgccctcat ccagtcgcta     1560

gactcctccc ggcgccagta ccaggagaag tataaacagg tggagcagta catgtccttc     1620

cacaagctcc cgcctgacac ccgacagcgc atccatgact actatgaaca ccgctaccaa     1680

ggcaagatgt ttgatgagga aagcatcctg ggtgagctga gtgagccact tcgagaggag     1740

atcatcaact ttaactgccg aaagctggtg gcatccatgc cactgtttgc caacgcagat     1800

cccaactttg tgacatccat gctgaccaag ttgcgtttcg aggtcttcca gcctggggat     1860

tacatcatcc gcgaaggcac catcggcaag aagatgtact ttatccagca cggcgtggtc     1920

agcgtgctca ctaagggcaa caaagagacc aagctggctg atggctccta ttttggagag     1980

atctgcttgc tgacccgggg tcggcgcaca gccagcgtca gagcggatac ttattgccgc     2040

ctctactcac tgagcgtgga caacttcaat gaggtgctgg aggagtatcc catgatgcgg     2100

agggccttcg agacggttgc gctggaccgc ctggaccgca taggcaagaa gaactccatc     2160

ctcctccaca aggtgcagca cgacctcaac tcaggcgtct tcaactacca agagaacgag     2220

atcatccagc agatcgtgcg gcatgaccgt gagatggccc actgtgctca ccgcgtccag     2280

gctgccgcct cagccacccc aacccccacg cctgttatat ggaccccgct gatccaggcg     2340

ccactgcagg ctgctgctgc tactacttcg gtggccatag ccctcacaca ccacccccgc     2400

ctgcccgccg ccatcttccg gccccctccc ggacctgggc tgggcaacct tggggctgga     2460

cagacaccga ggcacccaag gaggctgcag tccttgatcc cttcagctct gggctctgct     2520

tcacccgcca gcagcccctc acaggtggac acaccgtctt catcctcctt ccacatccaa     2580

cagctggctg gattctctgc acctcctgga ttgagccctc tcctgccctc ctctagctct     2640

tccccacctc caggagcctg cggttcccca ccagccccca caccctccac ctccactgcc     2700

gccgccgcct ccaccactgg gttcggccac tttcacaagg cgctgggtgg ctccctgtca     2760

tcctctgact ccccgctgct caccccactg caaccaggcg ctcgctctcc acaggctgcc     2820

cagccaccac ccccactgcc tggggcccga ggaggtctgg gactcctgga gcacttcttg     2880

ccgcccccac cctcctccag gtcaccatca tccagccctg ggcagctggg ccagcctcct     2940

ggagagttgt ccctaggtct ggcagctggt ccatcaagta caccagagac acccccacgg     3000

cctgagcgac catccttcat ggcaggggcc tctggagggg cttctcctgt agcctttacc     3060

ccccgaggag gcctcagtcc tccgggccac agcccggggc ccccaagaac tttcccgagt     3120

gccccacccc gggcctctgg ctcccatggt tccctgctcc tgccacctgc atccagccct     3180

ccacctcccc aggtcccaca gcgcaggggc acaccacccc tcacccctgg ccgcctcaca     3240

caggacctga agctcatctc agcctctcag ccagccctcc cccaggatgg ggcacagact     3300

ctccgcaggg cctcgcctca ctcctcaggg gagtcggtgg ctgccttctc actctacccc     3360

agagctgggg gtggcagtgg gagtagtggg ggccttgggc ctcctggaag gccatatggt     3420

gccatcccag gccaacatgt cactttgcct cggaagacat cctcaggttc tttgccaccc     3480

ccactttctt tgtttggggc aagagccgcc tcttctggag ggccccctct gactactgct     3540

gcaccccaga gggaacctgg cgctaggtct gagccagtac gctccaaact gccgtctaat     3600

ttatgagctg ggccctccct ccctcttctt tttcttgctc ctttcttcct tcaggtttaa     3660

ctgtgattag gagatatacc aacaacaata ataaccataa aaaaacatac cccagaaaaa     3720

caaaaagaca gcagaaaata accaggtatt cttagagcta tagatttttg gtcacttgct     3780

tttatagact attttaat                                                   3798


