                         SEQUENCE LISTING

<110>  LAM Therapeutics, Inc.
 
<120>  MUTAGENESIS METHODS

<130>  L0769.70000WO00

<150>  US 61/927,458
<151>  2014-01-14

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  1
guuuuagagc uagaaauagc aaguuaaaau                                        30


<210>  2
<211>  40
<212>  RNA
<213>  N. meningitidis

<400>  2
guuguagcuc ccuuucucga aagagaaccg uugcuacaau                             40


<210>  3
<211>  44
<212>  RNA
<213>  N. meningitidis

<400>  3
guuguagcuc ccuuucucga aagagaaccg uugcuacaau aagg                        44


<210>  4
<211>  101
<212>  RNA
<213>  N. meningitidis

<400>  4
guuguagcuc ccuuucucga aagagaaccg uugcuacaau aaggccgucu gaaaagaugu       60

gccgcaacgc ucugccccuu aaagcuucug cuuuaacggg c                          101


<210>  5
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  5
ctttggaaga acaacttaag gtcagattat tttgcttagt aaact                       45


<210>  6
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  6
agcagctgaa acagtgcaga gtaagatttt tatatgatgc cttta                       45


<210>  7
<211>  34
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  7
cuaauuccuc ucuucuccuc ucuccagguu guag                                   34


<210>  8
<211>  36
<212>  RNA
<213>  S. pyogenes

<400>  8
guuuuagagc uaugcuguuu ugaauggucc caaaac                                 36


<210>  9
<211>  38
<212>  RNA
<213>  S. pyogenes

<400>  9
uuguuggaac cauucaaaac agcauagcaa guuaaaau                               38


<210>  10
<211>  36
<212>  RNA
<213>  N. meningitidis

<400>  10
guuguagcuc ccuuucucau uucgcagugc uacaau                                 36


<210>  11
<211>  36
<212>  RNA
<213>  N. meningitidis

<400>  11
auugucgcac ugcgaaauga gaaccguugc uacaau                                 36


<210>  12
<211>  36
<212>  RNA
<213>  S. thermophilus

<400>  12
guuuuuguac ucucaagauu uaaguaacug uacaac                                 36


<210>  13
<211>  37
<212>  RNA
<213>  S. thermophilus

<400>  13
cuuacacagu uacuuaaauc uugcagaagc uacaaag                                37


<210>  14
<211>  36
<212>  RNA
<213>  T. denticola

<400>  14
guuugagagu uguguaauuu aagauggauc ucaaac                                 36


<210>  15
<211>  38
<212>  RNA
<213>  T. denticola

<400>  15
auuuaagauc caucuuaaau uacacaacga guucaaau                               38


<210>  16
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  16
guuguagcuc ccuuucuc                                                     18


<210>  17
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  17
gagaaccguu gcuacaau                                                     18


<210>  18
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  3' splice site

<400>  18
nsnunbnbnb bnbbnnnhag vh                                                22


<210>  19
<211>  7113
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  19
ctgacgcgcc ctgtagcggc gcattaagcg cggcgggtgt ggtggttacg cgcagcgtga       60

ccgctacact tgccagcgcc ctagcgcccg ctcctttcgc tttcttccct tcctttctcg      120

ccacgttcgc cggctttccc cgtcaagctc taaatcgggg gctcccttta gggttccgat      180

ttagtgcttt acggcacctc gaccccaaaa aacttgatta gggtgatggt tcacgtagtg      240

ggccatcgcc ctgatagacg gtttttcgcc ctttgacgtt ggagtccacg ttctttaata      300

gtggactctt gttccaaact ggaacaacac tcaaccctat ctcggtctat tcttttgatt      360

tataagggat tttgccgatt tcggcctatt ggttaaaaaa tgagctgatt taacaaaaat      420

ttaacgcgaa ttttaacaaa atattaacgc ttacaatttc cattcgccat tcaggctgcg      480

caactgttgg gaagggcgat cggtgcgggc ctcttcgcta ttacgccagc tggcgaaagg      540

gggatgtgct gcaaggcgat taagttgggt aacgccaggg ttttcccagt cacgacgttg      600

taaaacgacg gccagtgagc gcgcgtaata cgactcacta tagggcgaat tggagctcca      660

ccgcggccgc ccggtttatc gttaatatgg atcaatttga acagttgatt aacgtgtctc      720

tgctcaagtc tttgatcaaa acgcaaatcg acgaaaatgt gtcggacaat atcaagtcga      780

tgagcgaaaa actaaaaagg ctagaatacg acaatctcac agacagcgtt gagatatacg      840

gtattcacga cagcaggctg aataataaaa aaattagaaa ctattattta accctagaaa      900

gataatcata ttgtgacgta cgttaaagat aatcatgcgt aaaattgacg catgtgtttt      960

atcggtctgt atatcgaggt ttatttatta atttgaatag atattaagtt ttattatatt     1020

tacacttaca tactaataat aaattcaaca aacaatttat ttatgtttat ttatttatta     1080

aaaaaaaaca aaaactcaaa atttcttcta taaagtaaca aaacttttaa acattctctc     1140

ttttacaaaa ataaacttat tttgtacttt aaaaacagtc atgttgtatt ataaaataag     1200

taattagctt aacttataca taatagaaac aaattatact tattagtcag tcagaaacaa     1260

ctttggcaca tatcaatatt atgctctcga caaataactt ttttgcattt tttgcacgat     1320

gcatttgcct ttcgccttat tttagagggg cagtaagtac agtaagtacg ttttttcatt     1380

actggctctt cagtactgtc atctgatgta ccaggcactt catttggcaa aatattagag     1440

atattatcgc gcaaatatct cttcaaagta ggagcttcta aacgcttacg cataaacgat     1500

gacgtcaggc tcatgtaaag gtttctcata aattttttgc gactttgaac cttttctccc     1560

ttgctactga cattatggct gtatataata aaagaattta tgcaggcaat gtttatcatt     1620

ccgtacaata atgccatagg ccacctattc gtcttcctac tgcaggtcat cacagaacac     1680

atttggtcta gcgtgtccac tccgccttta gtttgattat aatacataac catttgcggt     1740

ttaccggtac tttcgttgat agaagcatcc tcatcacaag atgataataa gtataccatc     1800

ttagctggct tcggtttata tgagacgaga gtaaggggtc cgtcaaaaca aaacatcgat     1860

gttcccactg gcctggagcg actgtttttc agtacttccg gtatctcgcg tttgtttgat     1920

cgcacggttc ccacaatggt taattcgagc tcgcccaaac cgggcgcgcc taattcctct     1980

cttctcctct ctccaggttg tagctccctt tctcgaaaga gaaccgttgc tacaataagg     2040

ccgtctgaaa agatgtgccg caacgctctg ccccttaaag cttctgcttt aacgggcaat     2100

aaaatatctt tattttcatt acatctgtgt gttggttttt tgtgtgggat ccggctgtgg     2160

aatgtgtgtc agttagggtg tggaaagtcc ccaggctccc cagcaggcag aagtatgcaa     2220

agcatgcatc tcaattagtc agcaaccagg tgtggaaagt ccccaggctc cccagcaggc     2280

agaagtatgc aaagcatgca tctcaattag tcagcaacca tagtcccgcc cctaactccg     2340

cccatcccgc ccctaactcc gcccagttcc gcccattctc cgccccatgg ctgactaatt     2400

ttttttattt atgcagaggc cgaggccgcc tcggcctctg agctattcca gaagtagtga     2460

ggaggctttt ttggaggcct aggcttttgc aaaaagcttg ggctgcaggt cgaggcggat     2520

ctgatcaaga gacaggatga ggatcgtttc gcatgattga acaagatgga ttgcacgcag     2580

gttctccggc cgcttgggtg gagaggctat tcggctatga ctgggcacaa cagacaatcg     2640

gctgctctga tgccgccgtg ttccggctgt cagcgcaggg gcgcccggtt ctttttgtca     2700

agaccgacct gtccggtgcc ctgaatgaac tgcaggacga ggcagcgcgg ctatcgtggc     2760

tggccacgac gggcgttcct tgcgcagctg tgctcgacgt tgtcactgaa gcgggaaggg     2820

actggctgct attgggcgaa gtgccggggc aggatctcct gtcatctcac cttgctcctg     2880

ccgagaaagt atccatcatg gctgatgcaa tgcggcggct gcatacgctt gatccggcta     2940

cctgcccatt cgaccaccaa gcgaaacatc gcatcgagcg agcacgtact cggatggaag     3000

ccggtcttgt cgatcaggat gatctggacg aagagcatca ggggctcgcg ccagccgaac     3060

tgttcgccag gctcaaggcg cgcatgcccg acggcgagga tctcgtcgtg acccatggcg     3120

atgcctgctt gccgaatatc atggtggaaa atggccgctt ttctggattc atcgactgtg     3180

gccggctggg tgtggcggac cgctatcagg acatagcgtt ggctacccgt gatattgctg     3240

aagagcttgg cggcgaatgg gctgaccgct tcctcgtgct ttacggtatc gccgctcccg     3300

attcgcagcg catcgccttc tatcgccttc ttgacgagtt cttctgagcg ggactctggg     3360

gttcgataaa ataaaagatt ttatttagtc tccagaaaaa ggggggaatg aaagacccca     3420

cctgtaggtt tggcaagcta gcttaagtaa cgccattttg caaggcatgg aaaaatacat     3480

aactgagaat agagaagttc agatcaaggt caggaacaga tggaacagct gaatatgggc     3540

caaacaggat atctgtggta agcagttcct gccccggctc agggccaaga acagatggaa     3600

cagctgaata tgggccaaac aggatatctg tggtaagcag ttcctgcccc ggctcagggc     3660

caagaacaga tggtccccag atgcggtcca gccctcagca gtttctagag aaccatcaga     3720

tgtttccagg gtgccccaag gacctgaaat gaccctgtgc cttatttgaa ctaaccaatc     3780

agttcgcttc tcgcttctgt tcgcgcgctt ctgctccccg agctcaataa aagagcccac     3840

aacccctcac tcggggcgcc agtcctccga ttgactgagt cgcccagctt ggcgtaatca     3900

tggtcatagc tgtttcctgt gtgaaattgt tatccgctca caattccaca caacatacga     3960

gccggaagca taaagtgtaa agcctggggt gcctaatgag tgagctaact cacattaatt     4020

gcgttgcgct cactgcccgc tttccagtcg ggaaacctgt cgtgccagcg gatcgatctg     4080

acaatgttca gtgcagagac tcggctacgc ctcgtggact ttgaagttga ccaacaatgt     4140

ttattcttac ctctaatagt cctctgtggc aaggtcaaga ttctgttaga agccaatgaa     4200

gaacctggtt gttcaataac attttgttcg tctaatattt cactaccgct tgacgttggc     4260

tgcacttcat gtacctcatc tataaacgct tcttctgtat cgctctggac gtcatcttca     4320

cttacgtgat ctgatatttc actgtcagaa tcctcaccaa caagctcgtc atcgctttgc     4380

agaagagcag agaggatatg ctcatcgtct aaagaactac ccattttatt atatattagt     4440

cacgatatct ataacaagaa aatatatata taataagtta tcacgtaagt agaacatgaa     4500

ataacaatat aattatcgta tgagttaaat cttaaaagtc acgtaaaaga taatcatgcg     4560

tcattttgac tcacgcggtc gttatagttc aaaatcagtg acacttaccg cattgacaag     4620

cacgcctcac gggagctcca agcggcgact gagatgtcct aaatgcacag cgacggattc     4680

gcgctattta gaaagagaga gcaatatttc aagaatgcat gcgtcaattt tacgcagact     4740

atctttctag ggttaaaaaa gatttgcgct ttactcgacc taaactttaa acacgtcata     4800

gaatcttcgt ttgacaaaaa ccacattgtg gccaagctgt gtgacgcgac gcgcgctaaa     4860

gaatggcaaa ccaagtcgcg cgagcgtcga cctcgagggg gggcccggta cccagctttt     4920

gttcccttta gtgagggtta attgcgcgct tggcgtaatc atggtcatag ctgtttcctg     4980

tgtgaaattg ttatccgctc acaattccac acaacatacg agccggaagc ataaagtgta     5040

aagcctgggg tgcctaatga gtgagctaac tcacattaat tgcgttgcgc tcactgcccg     5100

ctttccagtc gggaaacctg tcgtgccagc tgcattaatg aatcggccaa cgcgcgggga     5160

gaggcggttt gcgtattggg cgctcttccg cttcctcgct cactgactcg ctgcgctcgg     5220

tcgttcggct gcggcgagcg gtatcagctc actcaaaggc ggtaatacgg ttatccacag     5280

aatcagggga taacgcagga aagaacatgt gagcaaaagg ccagcaaaag gccaggaacc     5340

gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg cccccctgac gagcatcaca     5400

aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg actataaaga taccaggcgt     5460

ttccccctgg aagctccctc gtgcgctctc ctgttccgac cctgccgctt accggatacc     5520

tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca tagctcacgc tgtaggtatc     5580

tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc     5640

ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc caacccggta agacacgact     5700

tatcgccact ggcagcagcc actggtaaca ggattagcag agcgaggtat gtaggcggtg     5760

ctacagagtt cttgaagtgg tggcctaact acggctacac tagaaggaca gtatttggta     5820

tctgcgctct gctgaagcca gttaccttcg gaaaaagagt tggtagctct tgatccggca     5880

aacaaaccac cgctggtagc ggtggttttt ttgtttgcaa gcagcagatt acgcgcagaa     5940

aaaaaggatc tcaagaagat cctttgatct tttctacggg gtctgacgct cagtggaacg     6000

aaaactcacg ttaagggatt ttggtcatga gattatcaaa aaggatcttc acctagatcc     6060

ttttaaatta aaaatgaagt tttaaatcaa tctaaagtat atatgagtaa acttggtctg     6120

acagttacca atgcttaatc agtgaggcac ctatctcagc gatctgtcta tttcgttcat     6180

ccatagttgc ctgactcccc gtcgtgtaga taactacgat acgggagggc ttaccatctg     6240

gccccagtgc tgcaatgata ccgcgagacc cacgctcacc ggctccagat ttatcagcaa     6300

taaaccagcc agccggaagg gccgagcgca gaagtggtcc tgcaacttta tccgcctcca     6360

tccagtctat taattgttgc cgggaagcta gagtaagtag ttcgccagtt aatagtttgc     6420

gcaacgttgt tgccattgct acaggcatcg tggtgtcacg ctcgtcgttt ggtatggctt     6480

cattcagctc cggttcccaa cgatcaaggc gagttacatg atcccccatg ttgtgcaaaa     6540

aagcggttag ctccttcggt cctccgatcg ttgtcagaag taagttggcc gcagtgttat     6600

cactcatggt tatggcagca ctgcataatt ctcttactgt catgccatcc gtaagatgct     6660

tttctgtgac tggtgagtac tcaaccaagt cattctgaga atagtgtatg cggcgaccga     6720

gttgctcttg cccggcgtca atacgggata ataccgcgcc acatagcaga actttaaaag     6780

tgctcatcat tggaaaacgt tcttcggggc gaaaactctc aaggatctta ccgctgttga     6840

gatccagttc gatgtaaccc actcgtgcac ccaactgatc ttcagcatct tttactttca     6900

ccagcgtttc tgggtgagca aaaacaggaa ggcaaaatgc cgcaaaaaag ggaataaggg     6960

cgacacggaa atgttgaata ctcatactct tcctttttca atattattga agcatttatc     7020

agggttattg tctcatgagc ggatacatat ttgaatgtat ttagaaaaat aaacaaatag     7080

gggttccgcg cacatttccc cgaaaagtgc cac                                  7113


<210>  20
<211>  8387
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  20
ggcctaactg gccggtacct gagctcgcta gcctcgagga tatcaagatc tcccgatccc       60

ctatggtcga ctctcagtac aatctgctct gatgccgcat agttaagcca gtatctgctc      120

cctgcttgtg tgttggaggt cgctgagtag tgcgcgagca aaatttaagc tacaacaagg      180

caaggcttga ccgacaattg catgaagaat ctgcttaggg ttaggcgttt tgcgctgctt      240

cgggggtgag gctccggtgc ccgtcgtgag gctccggtgc ccgtcagtgg gcagagcgca      300

catcgcccac agtccccgag aagttggggg gaggggtcgg caattgaacc ggtgcctaga      360

gaaggtggcg cggggtaaac tgggaaagtg atgtcgtgta ctggctccgc ctttttcccg      420

agggtggggg agaaccgtat ataagtgcag tagtcgccgt gaacgttctt tttcgcaacg      480

ggtttgccgc cagaacacag gtaagtgccg tgtgtggttc ccgcgggcct ggcctcttta      540

cgggttatgg cccttgcgtg ccttgaatta cttccacctg gctccagtac gtgattcttg      600

atcccgagct ggagccaggg gcgggccttg cgctttagga gccccttcgc ctcgtgcttg      660

agttgaggcc tggcctgggc gctggggccg ccgcgtgcga atctggtggc accttcgcgc      720

ctgtctcgct gctttcgata agtctctagc catttaaaat ttttgatgac ctgctgcgac      780

gctttttttc tggcaagata gtcttgtaaa tgcgggccag gatctgcaca ctggtatttc      840

ggtttttggg gccgcgggcg gcgacggggc ccgtgcgtcc cagcgcacat gttcggcgag      900

gcggggcctg cgagcgcggc caccgagaat cggacggggg tcggacgggg gtagtctcaa      960

gctggccggc ctgctctggt gcctggcctc gcgccgccgt gtatcgcccc gccctgggcg     1020

gcaaggctgg cccggtcggc accagttgcg tgagcggaaa gatggccgct tcccggccct     1080

gctccagggg gctcaaaatg gaggacgcgg cgctcgggag agcgggcggg tgagtcaccc     1140

acacaaagga aaggggcctt tccgtcctca gccgtcgctt catgtgactc cacggagtac     1200

cgggcgccgt ccaggcacct cgattagttc tggagctttt ggagtacgtc gtctttaggt     1260

tggggggagg ggttttatgc gatggagttt ccccacactg agtgggtgga gactgaagtt     1320

aggccagctt ggcacttgat gtaattctcc ttggaatttg ccctttttga gtttggatct     1380

tggttcattc tcaagcctca gacagtggtt caaagttttt ttcttccatt tcaggtgtcg     1440

tgaacaccgc caccatggtg cctaagaaga agagaaaggt ggctgccttc aaacctaatt     1500

caatcaacta catcctcggc ctcgatatcg gcatcgcatc cgtcggctgg gcgatggtag     1560

aaattgacga agaagaaaac cccatccgcc tgattgattt gggcgtgcgc gtatttgagc     1620

gtgccgaagt accgaaaaca ggcgactccc ttgccatggc aaggcgtttg gcgcgcagtg     1680

ttcgccgcct gacccgccgt cgcgcccacc gcctgcttcg gacccgccgc ctattgaaac     1740

gcgaaggcgt attacaagcc gccaattttg acgaaaacgg cttgattaaa tccttaccga     1800

atacaccatg gcaacttcgc gcagccgcat tagaccgcaa actgacgcct ttagagtggt     1860

cggcagtctt gttgcattta atcaaacatc gcggctattt atcgcaacgg aaaaacgagg     1920

gcgaaactgc cgataaggag cttggcgctt tgcttaaagg cgtagccggc aatgcccatg     1980

ccttacagac aggcgatttc cgcacaccgg ccgaattggc tttaaataaa tttgagaaag     2040

aaagcggcca tatccgcaat cagcgcagcg attattcgca tacgttcagc cgcaaagatt     2100

tacaggcgga gctgattttg ctgtttgaaa aacaaaaaga atttggcaat ccgcatgttt     2160

caggcggcct taaagaaggt attgaaaccc tactgatgac gcaacgccct gccctgtccg     2220

gcgatgccgt tcaaaaaatg ttggggcatt gcaccttcga accggcagag ccgaaagccg     2280

ctaaaaacac ctacacagcc gaacgtttca tctggctgac caagctgaac aacctgcgta     2340

ttttagagca aggcagcgag cggccattga ccgataccga acgcgccacg cttatggacg     2400

agccatacag aaaatccaaa ctgacttacg cacaagcccg taagctgctg ggtttagaag     2460

ataccgcctt tttcaaaggc ttgcgctatg gtaaagacaa tgccgaagcc tcaacattga     2520

tggaaatgaa ggcctaccat gccatcagcc gtgcactgga aaaagaagga ttgaaagaca     2580

aaaaatcccc attaaacctt tctcccgaat tacaagacga aatcggcacg gcattctccc     2640

tgttcaaaac cgatgaagac attacaggcc gtctgaaaga ccgtatacag cccgaaatct     2700

tagaagcgct gttgaaacac atcagcttcg ataagttcgt ccaaatttcc ttgaaagcat     2760

tgcgccgaat tgtgcctcta atggaacaag gcaaacgtta cgatgaagcc tgcgccgaaa     2820

tctacggaga ccattacggc aagaagaata cggaagaaaa gatttatctg ccgccgattc     2880

ccgccgacga aatccgcaac cccgtcgtct tgcgcgcctt atctcaagca cgtaaggtca     2940

ttaacggcgt ggtacgccgt tacggctccc cagctcgtat ccatattgaa actgcaaggg     3000

aagtaggtaa atcgtttaaa gaccgcaaag aaattgagaa acgccaagaa gaaaaccgca     3060

aagaccggga aaaagccgcc gccaaattcc gagagtattt ccccaatttt gtcggagaac     3120

ccaaatccaa agatattctg aaactgcgcc tgtacgagca acaacacggc aaatgcctgt     3180

attcgggcaa agaaatcaac ttaggccgtc tgaacgaaaa aggctatgtc gaaatcgacc     3240

atgccctgcc gttctcgcgc acatgggacg acagtttcaa caataaagta ctggtattgg     3300

gcagcgaaaa ccaaaacaaa ggcaatcaaa ccccttacga atacttcaac ggcaaagaca     3360

acagccgcga atggcaggaa tttaaagcgc gtgtcgaaac cagccgtttc ccgcgcagta     3420

aaaaacaacg gattctgctg caaaaattcg atgaagacgg ctttaaagaa cgcaatctga     3480

acgacacgcg ctacgtcaac cgtttcctgt gtcaatttgt tgccgaccgt atgcggctga     3540

caggtaaagg caagaaacgt gtctttgcat ccaacggaca aattaccaat ctgttgcgcg     3600

gcttttgggg attgcgcaaa gtgcgtgcgg aaaacgaccg ccatcacgcc ttggacgccg     3660

tcgtcgttgc ctgctcgacc gttgccatgc agcagaaaat tacccgtttt gtacgctata     3720

aagagatgaa cgcgtttgac ggtaaaacca tagacaaaga aacaggagaa gtgctgcatc     3780

aaaaaacaca cttcccacaa ccttgggaat ttttcgcaca agaagtcatg attcgcgtct     3840

tcggcaaacc ggacggcaaa cccgaattcg aagaagccga taccctagaa aaactgcgca     3900

cgttgcttgc cgaaaaatta tcatctcgcc ccgaagccgt acacgaatac gttacgccac     3960

tgtttgtttc acgcgcgccc aatcggaaga tgagcgggca agggcatatg gagaccgtca     4020

aatccgccaa acgactggac gaaggcgtca gcgtgttgcg cgtaccgctg acacagttaa     4080

aactgaaaga cttggaaaaa atggtcaatc gggagcgcga acctaagcta tacgaagcac     4140

tgaaagcacg gctggaagca cataaagacg atcctgccaa agcctttgcc gagccgtttt     4200

acaaatacga taaagcaggc aaccgcaccc aacaggtaaa agccgtacgc gtagagcaag     4260

tacagaaaac cggcgtatgg gtgcgcaacc ataacggtat tgccgacaac gcaaccatgg     4320

tgcgcgtaga tgtgtttgag aaaggcgaca agtattatct ggtaccgatt tacagttggc     4380

aggtagcgaa agggattttg ccggataggg ctgttgtaca aggaaaagat gaagaagatt     4440

ggcaacttat tgatgatagt ttcaacttta aattctcatt acaccctaat gatttagtcg     4500

aggttataac aaaaaaagct agaatgtttg gttactttgc cagctgccat cgaggcacag     4560

gtaatatcaa tatacgcatt catgatcttg atcataaaat tggcaaaaat ggaatactgg     4620

aaggtatcgg cgtcaaaacc gccctttcat tccaaaaata ccaaattgac gaactgggca     4680

aagaaatcag accatgccgt ctgaaaaaac gcccgcctgt ccgttaccca tacgatgttc     4740

cagattacgc tgcagctcca gcagcgaaga aaaagaagct ggattaactc gctgatcagc     4800

ctcgactgtg ccttctagtt gccagccatc tgttgtttgc ccctcccccg tgccttcctt     4860

gaccctggaa ggtgccactc ccactgtcct ttcctaataa aatgaggaaa ttgcatcgca     4920

ttgtctgagt aggtgtcatt ctattctggg gggtggggtg gggcaggaca gcaaggggga     4980

ggattgggaa gacaatagca gggatccgtt tgcgtattgg gcgctcttcc gctgatctgc     5040

gcagcaccat ggcctgaaat aacctctgaa agaggaactt ggttagctac cttctgaggc     5100

ggaaagaacc agctgtggaa tgtgtgtcag ttagggtgtg gaaagtcccc aggctcccca     5160

gcaggcagaa gtatgcaaag catgcatctc aattagtcag caaccaggtg tggaaagtcc     5220

ccaggctccc cagcaggcag aagtatgcaa agcatgcatc tcaattagtc agcaaccata     5280

gtcccgcccc taactccgcc catcccgccc ctaactccgc ccagttccgc ccattctccg     5340

ccccatggct gactaatttt ttttatttat gcagaggccg aggccgcctc tgcctctgag     5400

ctattccaga agtagtgagg aggctttttt ggaggcctag gcttttgcaa aaagctcgat     5460

tcttctgaca ctagcgccac catgaccgag tacaagccta ccgtgcgcct ggccactcgc     5520

gatgatgtgc cccgcgccgt ccgcactctg gccgccgctt tcgccgacta ccccgctacc     5580

cggcacaccg tggaccccga ccggcacatc gagcgtgtga cagagttgca ggagctgttc     5640

ctgacccgcg tcgggctgga catcggcaag gtgtgggtag ccgacgacgg cgcggccgtg     5700

gccgtgtgga ctacccccga gagcgttgag gccggcgccg tgttcgccga gatcggcccc     5760

cgaatggccg agctgagcgg cagccgcctg gccgcccagc agcaaatgga gggcctgctt     5820

gccccccatc gtcccaagga gcctgcctgg tttctggcca ctgtaggagt gagccccgac     5880

caccagggca agggcttggg cagcgccgtc gtgttgcccg gcgtagaggc cgccgaacgc     5940

gccggtgtgc ccgcctttct cgaaacaagc gcaccaagaa accttccatt ctacgagcgc     6000

ctgggcttca ccgtgaccgc cgatgtcgag gtgcccgagg gacctaggac ctggtgtatg     6060

acacgaaaac ctggcgccta atgatctaga accggtcatg gccgcaataa aatatcttta     6120

ttttcattac atctgtgtgt tggttttttg tgtgttcgaa ctagatgctg tcgaccgatg     6180

cccttgagag ccttcaaccc agtcagctcc ttccggtggg cgcggggcat gactatcgtc     6240

gccgcactta tgactgtctt ctttatcatg caactcgtag gacaggtgcc ggcagcgctc     6300

ttccgcttcc tcgctcactg actcgctgcg ctcggtcgtt cggctgcggc gagcggtatc     6360

agctcactca aaggcggtaa tacggttatc cacagaatca ggggataacg caggaaagaa     6420

catgtgagca aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt     6480

tttccatagg ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg     6540

gcgaaacccg acaggactat aaagatacca ggcgtttccc cctggaagct ccctcgtgcg     6600

ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc cttcgggaag     6660

cgtggcgctt tctcatagct cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc     6720

caagctgggc tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct tatccggtaa     6780

ctatcgtctt gagtccaacc cggtaagaca cgacttatcg ccactggcag cagccactgg     6840

taacaggatt agcagagcga ggtatgtagg cggtgctaca gagttcttga agtggtggcc     6900

taactacggc tacactagaa gaacagtatt tggtatctgc gctctgctga agccagttac     6960

cttcggaaaa agagttggta gctcttgatc cggcaaacaa accaccgctg gtagcggtgg     7020

tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag aagatccttt     7080

gatcttttct acggggtctg acgctcagtg gaacgaaaac tcacgttaag ggattttggt     7140

catgagatta tcaaaaagga tcttcaccta gatcctttta aattaaaaat gaagttttaa     7200

atcaatctaa agtatatatg agtaaacttg gtctgacagc ggccgcaaat gctaaaccac     7260

tgcagtggtt accagtgctt gatcagtgag gcaccgatct cagcgatctg cctatttcgt     7320

tcgtccatag tggcctgact ccccgtcgtg tagatcacta cgattcgtga gggcttacca     7380

tcaggcccca gcgcagcaat gatgccgcga gagccgcgtt caccggcccc cgatttgtca     7440

gcaatgaacc agccagcagg gagggccgag cgaagaagtg gtcctgctac tttgtccgcc     7500

tccatccagt ctatgagctg ctgtcgtgat gctagagtaa gaagttcgcc agtgagtagt     7560

ttccgaagag ttgtggccat tgctactggc atcgtggtat cacgctcgtc gttcggtatg     7620

gcttcgttca actctggttc ccagcggtca agccgggtca catgatcacc catattatga     7680

agaaatgcag tcagctcctt agggcctccg atcgttgtca gaagtaagtt ggccgcggtg     7740

ttgtcgctca tggtaatggc agcactacac aattctctta ccgtcatgcc atccgtaaga     7800

tgcttttccg tgaccggcga gtactcaacc aagtcgtttt gtgagtagtg tatacggcga     7860

ccaagctgct cttgcccggc gtctatacgg gacaacaccg cgccacatag cagtactttg     7920

aaagtgctca tcatcgggaa tcgttcttcg gggcggaaag actcaaggat cttgccgcta     7980

ttgagatcca gttcgatata gcccactctt gcacccagtt gatcttcagc atcttttact     8040

ttcaccagcg tttcggggtg tgcaaaaaca ggcaagcaaa atgccgcaaa gaagggaatg     8100

agtgcgacac gaaaatgttg gatgctcata ctcgtccttt ttcaatatta ttgaagcatt     8160

tatcagggtt actagtacgt ctctcaagga taagtaagta atattaaggt acgggaggta     8220

ttggacaggc cgcaataaaa tatctttatt ttcattacat ctgtgtgttg gttttttgtg     8280

tgaatcgata gtactaacat acgctctcca tcaaaacaaa acgaaacaaa acaaactagc     8340

aaaataggct gtccccagtg caagtgcagg tgccagaaca tttctct                   8387


<210>  21
<211>  1081
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  21

Ala Ala Phe Lys Pro Asn Ser Ile Asn Tyr Ile Leu Gly Leu Asp Ile 
1               5                   10                  15      


Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Glu Glu 
            20                  25                  30          


Asn Pro Ile Arg Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg Ala 
        35                  40                  45              


Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Ala Arg Arg Leu Ala 
    50                  55                  60                  


Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu Arg 
65                  70                  75                  80  


Thr Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asn Phe 
                85                  90                  95      


Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln Leu 
            100                 105                 110         


Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser Ala 
        115                 120                 125             


Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg Lys 
    130                 135                 140                 


Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys Gly 
145                 150                 155                 160 


Val Ala Gly Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr Pro 
                165                 170                 175     


Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile Arg 
            180                 185                 190         


Asn Gln Arg Ser Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu Gln 
        195                 200                 205             


Ala Glu Leu Ile Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn Pro 
    210                 215                 220                 


His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met Thr 
225                 230                 235                 240 


Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly His 
                245                 250                 255     


Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr Thr 
            260                 265                 270         


Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile Leu 
        275                 280                 285             


Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr Leu 
    290                 295                 300                 


Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala Arg 
305                 310                 315                 320 


Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg Tyr 
                325                 330                 335     


Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala Tyr 
            340                 345                 350         


His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys Lys 
        355                 360                 365             


Ser Pro Leu Asn Leu Ser Pro Glu Leu Gln Asp Glu Ile Gly Thr Ala 
    370                 375                 380                 


Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys Asp 
385                 390                 395                 400 


Arg Ile Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser Phe 
                405                 410                 415     


Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val Pro 
            420                 425                 430         


Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile Tyr 
        435                 440                 445             


Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu Pro 
    450                 455                 460                 


Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala Leu 
465                 470                 475                 480 


Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly Ser 
                485                 490                 495     


Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser Phe 
            500                 505                 510         


Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys Asp 
        515                 520                 525             


Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe Val 
    530                 535                 540                 


Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu Gln 
545                 550                 555                 560 


Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly Arg 
                565                 570                 575     


Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe Ser 
            580                 585                 590         


Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly Ser 
        595                 600                 605             


Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn Gly 
    610                 615                 620                 


Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu Thr 
625                 630                 635                 640 


Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys Phe 
                645                 650                 655     


Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr Val 
            660                 665                 670         


Asn Arg Phe Leu Cys Gln Phe Val Ala Asp Arg Met Arg Leu Thr Gly 
        675                 680                 685             


Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn Leu 
    690                 695                 700                 


Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp Arg 
705                 710                 715                 720 


His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala Met 
                725                 730                 735     


Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala Phe 
            740                 745                 750         


Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gln Lys 
        755                 760                 765             


Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met Ile 
    770                 775                 780                 


Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala Asp 
785                 790                 795                 800 


Thr Leu Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser Arg 
                805                 810                 815     


Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg Ala 
            820                 825                 830         


Pro Asn Arg Lys Met Ser Gly Gln Gly His Met Glu Thr Val Lys Ser 
        835                 840                 845             


Ala Lys Arg Leu Asp Glu Gly Val Ser Val Leu Arg Val Pro Leu Thr 
    850                 855                 860                 


Gln Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg Glu 
865                 870                 875                 880 


Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys Asp 
                885                 890                 895     


Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys Ala 
            900                 905                 910         


Gly Asn Arg Thr Gln Gln Val Lys Ala Val Arg Val Glu Gln Val Gln 
        915                 920                 925             


Lys Thr Gly Val Trp Val Arg Asn His Asn Gly Ile Ala Asp Asn Ala 
    930                 935                 940                 


Thr Met Val Arg Val Asp Val Phe Glu Lys Gly Asp Lys Tyr Tyr Leu 
945                 950                 955                 960 


Val Pro Ile Tyr Ser Trp Gln Val Ala Lys Gly Ile Leu Pro Asp Arg 
                965                 970                 975     


Ala Val Val Gln Gly Lys Asp Glu Glu Asp Trp Gln Leu Ile Asp Asp 
            980                 985                 990         


Ser Phe Asn Phe Lys Phe Ser Leu  His Pro Asn Asp Leu  Val Glu Val 
        995                 1000                 1005             


Ile Thr  Lys Lys Ala Arg Met  Phe Gly Tyr Phe Ala  Ser Cys His 
    1010                 1015                 1020             


Arg Gly  Thr Gly Asn Ile Asn  Ile Arg Ile His Asp  Leu Asp His 
    1025                 1030                 1035             


Lys Ile  Gly Lys Asn Gly Ile  Leu Glu Gly Ile Gly  Val Lys Thr 
    1040                 1045                 1050             


Ala Leu  Ser Phe Gln Lys Tyr  Gln Ile Asp Glu Leu  Gly Lys Glu 
    1055                 1060                 1065             


Ile Arg  Pro Cys Arg Leu Lys  Lys Arg Pro Pro Val  Arg 
    1070                 1075                 1080     


<210>  22
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  22

Met Thr Glu Tyr Lys Pro Thr Val Arg Leu Ala Thr Arg Asp Asp Val 
1               5                   10                  15      


Pro Arg Ala Val Arg Thr Leu Ala Ala Ala Phe Ala Asp Tyr Pro Ala 
            20                  25                  30          


Thr Arg His Thr Val Asp Pro Asp Arg His Ile Glu Arg Val Thr Glu 
        35                  40                  45              


Leu Gln Glu Leu Phe Leu Thr Arg Val Gly Leu Asp Ile Gly Lys Val 
    50                  55                  60                  


Trp Val Ala Asp Asp Gly Ala Ala Val Ala Val Trp Thr Thr Pro Glu 
65                  70                  75                  80  


Ser Val Glu Ala Gly Ala Val Phe Ala Glu Ile Gly Pro Arg Met Ala 
                85                  90                  95      


Glu Leu Ser Gly Ser Arg Leu Ala Ala Gln Gln Gln Met Glu Gly Leu 
            100                 105                 110         


Leu Ala Pro His Arg Pro Lys Glu Pro Ala Trp Phe Leu Ala Thr Val 
        115                 120                 125             


Gly Val Ser Pro Asp His Gln Gly Lys Gly Leu Gly Ser Ala Val Val 
    130                 135                 140                 


Leu Pro Gly Val Glu Ala Ala Glu Arg Ala Gly Val Pro Ala Phe Leu 
145                 150                 155                 160 


Glu Thr Ser Ala Pro Arg Asn Leu Pro Phe Tyr Glu Arg Leu Gly Phe 
                165                 170                 175     


Thr Val Thr Ala Asp Val Glu Val Pro Glu Gly Pro Arg Thr Trp Cys 
            180                 185                 190         


Met Thr Arg Lys Pro Gly Ala 
        195                 


<210>  23
<211>  286
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  23

Trp His Lys Ile Leu Ser Ala Gly Ile Glu Ala Ile Gln Arg Asn Arg 
1               5                   10                  15      


Glu Asp Met Thr Ala Gln Ser Gly Thr Thr Tyr Ile Val Val Ile Arg 
            20                  25                  30          


Ser Pro Lys Gly Asp Pro Gly Leu Ala Ala Ile Ile Gly Arg Ser Gly 
        35                  40                  45              


Arg Glu Gly Ala Gly Ser Lys Asp Ala Ile Phe Trp Gly Ala Pro Leu 
    50                  55                  60                  


Ala Ser Arg Leu Leu Pro Gly Ala Val Lys Asp Ala Glu Met Trp Asp 
65                  70                  75                  80  


Ile Leu Gln Gln Arg Ser Ala Leu Thr Leu Leu Glu Gly Thr Leu Leu 
                85                  90                  95      


Lys Arg Leu Thr Thr Ala Met Ala Val Pro Met Thr Thr Asp Arg Glu 
            100                 105                 110         


Asp Asn Pro Ile Ala Glu Asn Leu Glu Pro Glu Trp Arg Asp Leu Arg 
        115                 120                 125             


Thr Val His Asp Gly Met Asn His Leu Phe Ala Thr Leu Glu Lys Pro 
    130                 135                 140                 


Gly Gly Ile Thr Thr Leu Leu Leu Asn Ala Ala Thr Asn Asp Ser Met 
145                 150                 155                 160 


Thr Ile Ala Ala Ser Cys Leu Glu Arg Val Thr Met Gly Asp Thr Leu 
                165                 170                 175     


His Lys Glu Thr Val Pro Ser Tyr Glu Val Leu Asp Asn Gln Ser Tyr 
            180                 185                 190         


His Ile Arg Arg Gly Leu Gln Glu Gln Gly Ala Asp Ile Arg Ser Leu 
        195                 200                 205             


Val Ala Gly Cys Leu Leu Val Lys Phe Thr Ser Met Met Pro Phe Arg 
    210                 215                 220                 


Glu Glu Pro Arg Phe Ser Glu Leu Ile Lys Gly Ser Asn Leu Asp Leu 
225                 230                 235                 240 


Glu Ile Tyr Gly Val Arg Ala Gly Leu Gln Asp Glu Ala Asp Lys Val 
                245                 250                 255     


Lys Val Leu Thr Glu Pro His Ala Phe Val Pro Leu Cys Phe Ala Ala 
            260                 265                 270         


Phe Phe Pro Ile Leu Ala Val Arg Phe His Gln Ile Ser Met 
        275                 280                 285     


