                         SEQUENCE LISTING

<110>  SANOFI
 
<120>  METHODS OF IDENTIFYING PATIENTS SUFFERING FROM LIVER CANCER WHO 
       WILL MOST LIKELY BENEFIT FROM A TREATMENT WITH AN ANTAGONIST 
       ANTI-FGFR4 ANTIBODY

<130>  BEX15P0006

<150>  EP14305065.6
<151>  2014-01-17

<160>  98    

<170>  PatentIn version 3.5

<210>  1
<211>  52
<212>  DNA
<213>  Homo sapiens


<220>
<221>  variation
<222>  (27)..(27)
<223>  SNP is C or T

<400>  1
gtggagcgcc tgccctcgat acagcccggc cagcagcagg agcacagcca ag               52


<210>  2
<211>  3084
<212>  DNA
<213>  Homo sapiens

<400>  2
ctcgctcccg gccgaggagc gctcgggctg tctgcggacc ctgccgcgtg caggggtcgc       60

ggccggctgg agctgggagt gaggcggcgg aggagccagg tgaggaggag ccaggtgagc      120

aggaccctgt gctgggcgcg gagtcacgca ggctcgagga aggcagttgg tgggaagtcc      180

agcttgggtc cctgagagct gtgagaagga gatgcggctg ctgctggccc tgttgggggt      240

cctgctgagt gtgcctgggc ctccagtctt gtccctggag gcctctgagg aagtggagct      300

tgagccctgc ctggctccca gcctggagca gcaagagcag gagctgacag tagcccttgg      360

gcagcctgtg cgtctgtgct gtgggcgggc tgagcgtggt ggccactggt acaaggaggg      420

cagtcgcctg gcacctgctg gccgtgtacg gggctggagg ggccgcctag agattgccag      480

cttcctacct gaggatgctg gccgctacct ctgcctggca cgaggctcca tgatcgtcct      540

gcagaatctc accttgatta caggtgactc cttgacctcc agcaacgatg atgaggaccc      600

caagtcccat agggacccct cgaataggca cagttacccc cagcaagcac cctactggac      660

acacccccag cgcatggaga agaaactgca tgcagtacct gcggggaaca ccgtcaagtt      720

ccgctgtcca gctgcaggca accccacgcc caccatccgc tggcttaagg atggacaggc      780

ctttcatggg gagaaccgca ttggaggcat tcggctgcgc catcagcact ggagtctcgt      840

gatggagagc gtggtgccct cggaccgcgg cacatacacc tgcctggtag agaacgctgt      900

gggcagcatc cgctataact acctgctaga tgtgctggag cggtccccgc accggcccat      960

cctgcaggcc gggctcccgg ccaacaccac agccgtggtg ggcagcgacg tggagctgct     1020

gtgcaaggtg tacagcgatg cccagcccca catccagtgg ctgaagcaca tcgtcatcaa     1080

cggcagcagc ttcggagccg acggtttccc ctatgtgcaa gtcctaaaga ctgcagacat     1140

caatagctca gaggtggagg tcctgtacct gcggaacgtg tcagccgagg acgcaggcga     1200

gtacacctgc ctcgcaggca attccatcgg cctctcctac cagtctgcct ggctcacggt     1260

gctgccagag gaggacccca catggaccgc agcagcgccc gaggccaggt atacggacat     1320

catcctgtac gcgtcgggct ccctggcctt ggctgtgctc ctgctgctgg ccgggctgta     1380

tcgagggcag gcgctccacg gccggcaccc ccgcccgccc gccactgtgc agaagctctc     1440

ccgcttccct ctggcccgac agttctccct ggagtcaggc tcttccggca agtcaagctc     1500

atccctggta cgaggcgtgc gtctctcctc cagcggcccc gccttgctcg ccggcctcgt     1560

gagtctagat ctacctctcg acccactatg ggagttcccc cgggacaggc tggtgcttgg     1620

gaagccccta ggcgagggct gctttggcca ggtagtacgt gcagaggcct ttggcatgga     1680

ccctgcccgg cctgaccaag ccagcactgt ggccgtcaag atgctcaaag acaacgcctc     1740

tgacaaggac ctggccgacc tggtctcgga gatggaggtg atgaagctga tcggccgaca     1800

caagaacatc atcaacctgc ttggtgtctg cacccaggaa gggcccctgt acgtgatcgt     1860

ggagtgcgcc gccaagggaa acctgcggga gttcctgcgg gcccggcgcc ccccaggccc     1920

cgacctcagc cccgacggtc ctcggagcag tgaggggccg ctctccttcc cagtcctggt     1980

ctcctgcgcc taccaggtgg cccgaggcat gcagtatctg gagtcccgga agtgtatcca     2040

ccgggacctg gctgcccgca atgtgctggt gactgaggac aatgtgatga agattgctga     2100

ctttgggctg gcccgcggcg tccaccacat tgactactat aagaaaacca gcaacggccg     2160

cctgcctgtg aagtggatgg cgcccgaggc cttgtttgac cgggtgtaca cacaccagag     2220

tgacgtgtgg tcttttggga tcctgctatg ggagatcttc accctcgggg gctccccgta     2280

tcctggcatc ccggtggagg agctgttctc gctgctgcgg gagggacatc ggatggaccg     2340

acccccacac tgccccccag agctgtacgg gctgatgcgt gagtgctggc acgcagcgcc     2400

ctcccagagg cctaccttca agcagctggt ggaggcgctg gacaaggtcc tgctggccgt     2460

ctctgaggag tacctcgacc tccgcctgac cttcggaccc tattccccct ctggtgggga     2520

cgccagcagc acctgctcct ccagcgattc tgtcttcagc cacgaccccc tgccattggg     2580

atccagctcc ttccccttcg ggtctggggt gcagacatga gcaaggctca aggctgtgca     2640

ggcacatagg ctggtggcct tgggccttgg ggctcagcca cagcctgaca cagtgctcga     2700

ccttgatagc atggggcccc tggcccagag ttgctgtgcc gtgtccaagg gccgtgccct     2760

tgcccttgga gctgccgtgc ctgtgtcctg atggcccaaa tgtcagggtt ctgctcggct     2820

tcttggacct tggcgcttag tccccatccc gggtttggct gagcctggct ggagagctgc     2880

tatgctaaac ctcctgcctc ccaataccag caggaggttc tgggcctctg aacccccttt     2940

ccccacacct ccccctgctg ctgctgcccc agcgtcttga cgggagcatt ggcccctgag     3000

cccagagaag ctggaagcct gccgaaaaca ggagcaaatg gcgttttata aattattttt     3060

ttgaaataaa aaaaaaaaaa aaaa                                            3084


<210>  3
<211>  802
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Arg Leu Leu Leu Ala Leu Leu Gly Val Leu Leu Ser Val Pro Gly 
1               5                   10                  15      


Pro Pro Val Leu Ser Leu Glu Ala Ser Glu Glu Val Glu Leu Glu Pro 
            20                  25                  30          


Cys Leu Ala Pro Ser Leu Glu Gln Gln Glu Gln Glu Leu Thr Val Ala 
        35                  40                  45              


Leu Gly Gln Pro Val Arg Leu Cys Cys Gly Arg Ala Glu Arg Gly Gly 
    50                  55                  60                  


His Trp Tyr Lys Glu Gly Ser Arg Leu Ala Pro Ala Gly Arg Val Arg 
65                  70                  75                  80  


Gly Trp Arg Gly Arg Leu Glu Ile Ala Ser Phe Leu Pro Glu Asp Ala 
                85                  90                  95      


Gly Arg Tyr Leu Cys Leu Ala Arg Gly Ser Met Ile Val Leu Gln Asn 
            100                 105                 110         


Leu Thr Leu Ile Thr Gly Asp Ser Leu Thr Ser Ser Asn Asp Asp Glu 
        115                 120                 125             


Asp Pro Lys Ser His Arg Asp Pro Ser Asn Arg His Ser Tyr Pro Gln 
    130                 135                 140                 


Gln Ala Pro Tyr Trp Thr His Pro Gln Arg Met Glu Lys Lys Leu His 
145                 150                 155                 160 


Ala Val Pro Ala Gly Asn Thr Val Lys Phe Arg Cys Pro Ala Ala Gly 
                165                 170                 175     


Asn Pro Thr Pro Thr Ile Arg Trp Leu Lys Asp Gly Gln Ala Phe His 
            180                 185                 190         


Gly Glu Asn Arg Ile Gly Gly Ile Arg Leu Arg His Gln His Trp Ser 
        195                 200                 205             


Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly Thr Tyr Thr Cys 
    210                 215                 220                 


Leu Val Glu Asn Ala Val Gly Ser Ile Arg Tyr Asn Tyr Leu Leu Asp 
225                 230                 235                 240 


Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro 
                245                 250                 255     


Ala Asn Thr Thr Ala Val Val Gly Ser Asp Val Glu Leu Leu Cys Lys 
            260                 265                 270         


Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Ile Val 
        275                 280                 285             


Ile Asn Gly Ser Ser Phe Gly Ala Asp Gly Phe Pro Tyr Val Gln Val 
    290                 295                 300                 


Leu Lys Thr Ala Asp Ile Asn Ser Ser Glu Val Glu Val Leu Tyr Leu 
305                 310                 315                 320 


Arg Asn Val Ser Ala Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly 
                325                 330                 335     


Asn Ser Ile Gly Leu Ser Tyr Gln Ser Ala Trp Leu Thr Val Leu Pro 
            340                 345                 350         


Glu Glu Asp Pro Thr Trp Thr Ala Ala Ala Pro Glu Ala Arg Tyr Thr 
        355                 360                 365             


Asp Ile Ile Leu Tyr Ala Ser Gly Ser Leu Ala Leu Ala Val Leu Leu 
    370                 375                 380                 


Leu Leu Ala Gly Leu Tyr Arg Gly Gln Ala Leu His Gly Arg His Pro 
385                 390                 395                 400 


Arg Pro Pro Ala Thr Val Gln Lys Leu Ser Arg Phe Pro Leu Ala Arg 
                405                 410                 415     


Gln Phe Ser Leu Glu Ser Gly Ser Ser Gly Lys Ser Ser Ser Ser Leu 
            420                 425                 430         


Val Arg Gly Val Arg Leu Ser Ser Ser Gly Pro Ala Leu Leu Ala Gly 
        435                 440                 445             


Leu Val Ser Leu Asp Leu Pro Leu Asp Pro Leu Trp Glu Phe Pro Arg 
    450                 455                 460                 


Asp Arg Leu Val Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln 
465                 470                 475                 480 


Val Val Arg Ala Glu Ala Phe Gly Met Asp Pro Ala Arg Pro Asp Gln 
                485                 490                 495     


Ala Ser Thr Val Ala Val Lys Met Leu Lys Asp Asn Ala Ser Asp Lys 
            500                 505                 510         


Asp Leu Ala Asp Leu Val Ser Glu Met Glu Val Met Lys Leu Ile Gly 
        515                 520                 525             


Arg His Lys Asn Ile Ile Asn Leu Leu Gly Val Cys Thr Gln Glu Gly 
    530                 535                 540                 


Pro Leu Tyr Val Ile Val Glu Cys Ala Ala Lys Gly Asn Leu Arg Glu 
545                 550                 555                 560 


Phe Leu Arg Ala Arg Arg Pro Pro Gly Pro Asp Leu Ser Pro Asp Gly 
                565                 570                 575     


Pro Arg Ser Ser Glu Gly Pro Leu Ser Phe Pro Val Leu Val Ser Cys 
            580                 585                 590         


Ala Tyr Gln Val Ala Arg Gly Met Gln Tyr Leu Glu Ser Arg Lys Cys 
        595                 600                 605             


Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn 
    610                 615                 620                 


Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Gly Val His His Ile 
625                 630                 635                 640 


Asp Tyr Tyr Lys Lys Thr Ser Asn Gly Arg Leu Pro Val Lys Trp Met 
                645                 650                 655     


Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val 
            660                 665                 670         


Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser 
        675                 680                 685             


Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Ser Leu Leu Arg Glu 
    690                 695                 700                 


Gly His Arg Met Asp Arg Pro Pro His Cys Pro Pro Glu Leu Tyr Gly 
705                 710                 715                 720 


Leu Met Arg Glu Cys Trp His Ala Ala Pro Ser Gln Arg Pro Thr Phe 
                725                 730                 735     


Lys Gln Leu Val Glu Ala Leu Asp Lys Val Leu Leu Ala Val Ser Glu 
            740                 745                 750         


Glu Tyr Leu Asp Leu Arg Leu Thr Phe Gly Pro Tyr Ser Pro Ser Gly 
        755                 760                 765             


Gly Asp Ala Ser Ser Thr Cys Ser Ser Ser Asp Ser Val Phe Ser His 
    770                 775                 780                 


Asp Pro Leu Pro Leu Gly Ser Ser Ser Phe Pro Phe Gly Ser Gly Val 
785                 790                 795                 800 


Gln Thr 
        


<210>  4
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  4

Gln Ala Pro Tyr Trp Thr His Pro Gln Arg Met Glu Lys Lys Leu His 
1               5                   10                  15      


Ala Val Pro Ala Gly Asn Thr Val Lys Phe Arg Cys Pro Ala Ala Gly 
            20                  25                  30          


Asn Pro Thr Pro Thr Ile Arg Trp Leu Lys Asp Gly Gln Ala Phe His 
        35                  40                  45              


Gly Glu Asn Arg Ile Gly Gly Ile Arg Leu Arg His Gln His Trp Ser 
    50                  55                  60                  


Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly Thr Tyr Thr Cys 
65                  70                  75                  80  


Leu Val Glu Asn Ala Val Gly Ser Ile Arg Tyr Asn Tyr Leu Leu Asp 
                85                  90                  95      


Val Leu 
        


<210>  5
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  5

Thr Ser Gly Met Gly Val Ser 
1               5           


<210>  6
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  6

His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  7
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  7

Asp Tyr Tyr Ala Ser Ser Phe Asp Tyr 
1               5                   


<210>  8
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  8

Arg Ala Ser Gln Ser Ile Ser Asn Tyr Leu His 
1               5                   10      


<210>  9
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  9

Tyr Ala Ser Gln Ser Ile Ser 
1               5           


<210>  10
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  10

Gln Gln Ser Asn Ser Trp Pro Phe Thr 
1               5                   


<210>  11
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  11

Ser Asn Met Gly Ser Asn Tyr Ala His 
1               5                   


<210>  12
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  12

Tyr Asn Asn Asn Gln 
1               5   


<210>  13
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  13

Ala Trp Asp Asp Ser Leu Ser Gly 
1               5               


<210>  14
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  14

Phe Thr Phe Ser Pro Tyr Trp Met Gly 
1               5                   


<210>  15
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  15

Val Ile Trp Pro Ser Gly Gly Thr Thr Asp 
1               5                   10  


<210>  16
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  16

Arg Val His Pro Ala Gly His Asn Asp His 
1               5                   10  


<210>  17
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  17

Ser Ile Asn Arg Asn Leu Gly 
1               5           


<210>  18
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  18

Tyr Gly Ala Ser Thr 
1               5   


<210>  19
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  19

Gln Tyr Asp Asn Trp Pro 
1               5       


<210>  20
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  20

Phe Thr Phe Ser Arg Tyr Phe Met Lys 
1               5                   


<210>  21
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  21

Trp Ile Ser Pro Ser Gly Gly Leu Thr Glu 
1               5                   10  


<210>  22
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  22

Arg Ala Ser Tyr Gly Ala Trp Leu Asp Tyr 
1               5                   10  


<210>  23
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  23

Ser Asn Ile Gly Ser Asn Ser Val Asn 
1               5                   


<210>  24
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  24

Tyr Ser Asn Asn Leu 
1               5   


<210>  25
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  25

Ala Trp Asp Asp Gly Leu Asp Ala Tyr 
1               5                   


<210>  26
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  26

Phe Thr Phe Ser Thr Tyr Trp Met Ala 
1               5                   


<210>  27
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  27

Val Ile Gly Pro Ser Gly Gly Met Thr Val 
1               5                   10  


<210>  28
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  28

Arg Ile Asn Ser Gly Ser Ser His Phe Asp Tyr 
1               5                   10      


<210>  29
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  29

Ser Asn Ile Gly Ser Asn Ile Val His 
1               5                   


<210>  30
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  30

Tyr Gly Asn Asn Gln 
1               5   


<210>  31
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  31

Ser Trp Asp Asp Ser Leu Lys Ala Phe 
1               5                   


<210>  32
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  32

Phe Thr Phe Ser His Tyr Trp Met Gly 
1               5                   


<210>  33
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  33

Val Ile Ser Pro Ser Gly Gly Leu Thr Ile 
1               5                   10  


<210>  34
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  34

Arg Ser Ser Gly Trp Ala Leu Asp Ala Phe Asp Ile 
1               5                   10          


<210>  35
<211>  1389
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(1389)

<400>  35
atg aac agg ctt act tcc tca ttg ctg ctg ctg att gtc cct gca tat         48
Met Asn Arg Leu Thr Ser Ser Leu Leu Leu Leu Ile Val Pro Ala Tyr           
1               5                   10                  15                

gtc ctg tcc cag gtt act ctg aaa gag tct ggc cct ggg ata ttg cag         96
Val Leu Ser Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln           
            20                  25                  30                    

ccc tcc cag acc ctc agt ctg act tgt tct ttc tct ggg ttt tca ctg        144
Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu           
        35                  40                  45                        

agc act tct ggt atg ggt gtg agc tgg att cgt cag cct tca gga aag        192
Ser Thr Ser Gly Met Gly Val Ser Trp Ile Arg Gln Pro Ser Gly Lys           
    50                  55                  60                            

ggt ctg gag tgg ctg gca cac att tac tgg gat gat gac aag cgc tat        240
Gly Leu Glu Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr           
65                  70                  75                  80            

aac cca tcc ctg aag agc cgg ctc aca atc tcc aag gat acc tcc agc        288
Asn Pro Ser Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser           
                85                  90                  95                

aac cag gta ttc ctc aag atc acc agt gtg gac act gca gat act gcc        336
Asn Gln Val Phe Leu Lys Ile Thr Ser Val Asp Thr Ala Asp Thr Ala           
            100                 105                 110                   

aca tac tac tgt gct cga gat tac tac gct agt agc ttt gac tac tgg        384
Thr Tyr Tyr Cys Ala Arg Asp Tyr Tyr Ala Ser Ser Phe Asp Tyr Trp           
        115                 120                 125                       

ggc caa ggc acc act ctc aca gtc tcc tca gcc aaa acg aca ccc cca        432
Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Pro Pro           
    130                 135                 140                           

tct gtc tat cca ctg gcc cct gga tct gct gcc caa act aac tcc atg        480
Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met           
145                 150                 155                 160           

gtg acc ctg gga tgc ctg gtc aag ggc tat ttc cct gag cca gtg aca        528
Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr           
                165                 170                 175               

gtg acc tgg aac tct gga tcc ctg tcc agc ggt gtg cac acc ttc cca        576
Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro           
            180                 185                 190                   

gct gtc ctg cag tct gac ctc tac act ctg agc agc tca gtg act gtc        624
Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val           
        195                 200                 205                       

ccc tcc agc acc tgg ccc agc gag acc gtc acc tgc aac gtt gcc cac        672
Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His           
    210                 215                 220                           

ccg gcc agc agc acc aag gtg gac aag aaa att gtg ccc agg gat tgt        720
Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys           
225                 230                 235                 240           

ggt tgt aag cct tgc ata tgt aca gtc cca gaa gta tca tct gtc ttc        768
Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe           
                245                 250                 255               

atc ttc ccc cca aag ccc aag gat gtg ctc acc att act ctg act cct        816
Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro           
            260                 265                 270                   

aag gtc acg tgt gtt gtg gta gac atc agc aag gat gat ccc gag gtc        864
Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val           
        275                 280                 285                       

cag ttc agc tgg ttt gta gat gat gtg gag gtg cac aca gct cag acg        912
Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr           
    290                 295                 300                           

caa ccc cgg gag gag cag ttc aac agc act ttc cgc tca gtc agt gaa        960
Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu           
305                 310                 315                 320           

ctt ccc atc atg cac cag gac tgg ctc aat ggc aag gag ttc aaa tgc       1008
Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys           
                325                 330                 335               

agg gtc aac agt gca gct ttc cct gcc ccc atc gag aaa acc atc tcc       1056
Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser           
            340                 345                 350                   

aaa acc aaa ggc aga ccg aag gct cca cag gtg tac acc att cca cct       1104
Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro           
        355                 360                 365                       

ccc aag gag cag atg gcc aag gat aaa gtc agt ctg acc tgc atg ata       1152
Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile           
    370                 375                 380                           

aca gac ttc ttc cct gaa gac att act gtg gag tgg cag tgg aat ggg       1200
Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly           
385                 390                 395                 400           

cag cca gcg gag aac tac aag aac act cag ccc atc atg gac aca gat       1248
Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp           
                405                 410                 415               

ggc tct tac ttc gtc tac agc aag ctc aat gtg cag aag agc aac tgg       1296
Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp           
            420                 425                 430                   

gag gca gga aat act ttc acc tgc tct gtg tta cat gag ggc ctg cac       1344
Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His           
        435                 440                 445                       

aac cac cat act gag aag agc ctc tcc cac tct cct ggt aag tga           1389
Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys                   
    450                 455                 460                           


<210>  36
<211>  462
<212>  PRT
<213>  Mus musculus

<400>  36

Met Asn Arg Leu Thr Ser Ser Leu Leu Leu Leu Ile Val Pro Ala Tyr 
1               5                   10                  15      


Val Leu Ser Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu 
        35                  40                  45              


Ser Thr Ser Gly Met Gly Val Ser Trp Ile Arg Gln Pro Ser Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr 
65                  70                  75                  80  


Asn Pro Ser Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser 
                85                  90                  95      


Asn Gln Val Phe Leu Lys Ile Thr Ser Val Asp Thr Ala Asp Thr Ala 
            100                 105                 110         


Thr Tyr Tyr Cys Ala Arg Asp Tyr Tyr Ala Ser Ser Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Pro Pro 
    130                 135                 140                 


Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met 
145                 150                 155                 160 


Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val 
        195                 200                 205             


Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His 
    210                 215                 220                 


Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys 
225                 230                 235                 240 


Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe 
                245                 250                 255     


Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro 
            260                 265                 270         


Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val 
        275                 280                 285             


Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr 
    290                 295                 300                 


Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu 
305                 310                 315                 320 


Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys 
                325                 330                 335     


Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         


Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro 
        355                 360                 365             


Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile 
    370                 375                 380                 


Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly 
385                 390                 395                 400 


Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp 
                405                 410                 415     


Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp 
            420                 425                 430         


Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His 
        435                 440                 445             


Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
    450                 455                 460         


<210>  37
<211>  705
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(705)

<400>  37
atg gtt ttc aca cct cag att ctt gga ctt atg ctt ttc tgg att tca         48
Met Val Phe Thr Pro Gln Ile Leu Gly Leu Met Leu Phe Trp Ile Ser           
1               5                   10                  15                

gcc tcc aga ggt gat att gtg cta act cag tct cca gcc acc ctg tct         96
Ala Ser Arg Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser           
            20                  25                  30                    

gtg act cca gga gat aga gtc agt ctt tcc tgc agg gcc agt caa agt        144
Val Thr Pro Gly Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Ser           
        35                  40                  45                        

att agc aac tac cta cac tgg tat caa caa aaa tca cat gag tct cca        192
Ile Ser Asn Tyr Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro           
    50                  55                  60                            

agg ctt ctc atc aag tat gct tcc cag tcc atc tct ggg atc ccc tcc        240
Arg Leu Leu Ile Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser           
65                  70                  75                  80            

agg ttc agt ggc agt gga tca ggg aca gat ttc att ctc agt ttc aac        288
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ile Leu Ser Phe Asn           
                85                  90                  95                

agt gtg gag act gaa gat ttt gga atg tat ttc tgt caa cag agt aac        336
Ser Val Glu Thr Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln Ser Asn           
            100                 105                 110                   

agc tgg cct ttc acg ttc ggc tcg ggg aca aaa ttg gaa ata aaa cgg        384
Ser Trp Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg           
        115                 120                 125                       

gct gat gct gca cca act gta tcc atc ttc cca cca tcc agt gag cag        432
Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln           
    130                 135                 140                           

tta aca tct gga ggt gcc tca gtc gtg tgc ttc ttg aac aac ttc tac        480
Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr           
145                 150                 155                 160           

ccc aaa gac atc aat gtc aag tgg aag att gat ggc agt gaa cga caa        528
Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln           
                165                 170                 175               

aat ggc gtc ctg aac agt tgg act gat cag gac agc aaa gac agc acc        576
Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr           
            180                 185                 190                   

tac agc atg agc agc acc ctc acg ttg acc aag gac gag tat gaa cga        624
Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg           
        195                 200                 205                       

cat aac agc tat acc tgt gag gcc act cac aag aca tca act tca ccc        672
His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro           
    210                 215                 220                           

att gtc aag agc ttc aac agg aat gag tgt taa                            705
Ile Val Lys Ser Phe Asn Arg Asn Glu Cys                                   
225                 230                                                   


<210>  38
<211>  234
<212>  PRT
<213>  Mus musculus

<400>  38

Met Val Phe Thr Pro Gln Ile Leu Gly Leu Met Leu Phe Trp Ile Ser 
1               5                   10                  15      


Ala Ser Arg Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Val Thr Pro Gly Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Ile Ser Asn Tyr Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro 
    50                  55                  60                  


Arg Leu Leu Ile Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ile Leu Ser Phe Asn 
                85                  90                  95      


Ser Val Glu Thr Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln Ser Asn 
            100                 105                 110         


Ser Trp Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln 
    130                 135                 140                 


Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln 
                165                 170                 175     


Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg 
        195                 200                 205             


His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro 
    210                 215                 220                 


Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 


<210>  39
<211>  442
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (29)..(442)

<400>  39
tgaaggagta gaaaactagt gtgcagat atg aac agg ctt act tcc tca ttg          52
                               Met Asn Arg Leu Thr Ser Ser Leu            
                               1               5                          

ctg ctg ctg att gtc cct gca tat gtc ctg tcc cag gtt act ctg aaa        100
Leu Leu Leu Ile Val Pro Ala Tyr Val Leu Ser Gln Val Thr Leu Lys           
    10                  15                  20                            

gag tct ggc cct ggg ata ttg cag ccc tcc cag acc ctc agt ctg act        148
Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln Thr Leu Ser Leu Thr           
25                  30                  35                  40            

tgt tct ttc tct ggg ttt tca ctg agc act tct ggt atg ggt gtg agc        196
Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser Gly Met Gly Val Ser           
                45                  50                  55                

tgg att cgt cag cct tca gga aag ggt ctg gag tgg ctg gca cac att        244
Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu Trp Leu Ala His Ile           
            60                  65                  70                    

tac tgg gat gat gac aag cgc tat aac cca tcc ctg aag agc cgg ctc        292
Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser Leu Lys Ser Arg Leu           
        75                  80                  85                        

aca atc tcc aag gat acc tcc agc aac cag gta ttc ctc aag atc acc        340
Thr Ile Ser Lys Asp Thr Ser Ser Asn Gln Val Phe Leu Lys Ile Thr           
    90                  95                  100                           

agt gtg gac act gca gat act gcc aca tac tac tgt gct cga gat tac        388
Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Asp Tyr           
105                 110                 115                 120           

tac gct agt agc ttt gac tac tgg ggc caa ggc acc act ctc aca gtc        436
Tyr Ala Ser Ser Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val           
                125                 130                 135               

tcc tca                                                                442
Ser Ser                                                                   
                                                                          


<210>  40
<211>  138
<212>  PRT
<213>  Mus musculus

<400>  40

Met Asn Arg Leu Thr Ser Ser Leu Leu Leu Leu Ile Val Pro Ala Tyr 
1               5                   10                  15      


Val Leu Ser Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu 
        35                  40                  45              


Ser Thr Ser Gly Met Gly Val Ser Trp Ile Arg Gln Pro Ser Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr 
65                  70                  75                  80  


Asn Pro Ser Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser 
                85                  90                  95      


Asn Gln Val Phe Leu Lys Ile Thr Ser Val Asp Thr Ala Asp Thr Ala 
            100                 105                 110         


Thr Tyr Tyr Cys Ala Arg Asp Tyr Tyr Ala Ser Ser Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
    130                 135             


<210>  41
<211>  401
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (18)..(401)

<400>  41
tcagggaaag ctcgaag atg gtt ttc aca cct cag att ctt gga ctt atg          50
                   Met Val Phe Thr Pro Gln Ile Leu Gly Leu Met            
                   1               5                   10                 

ctt ttc tgg att tca gcc tcc aga ggt gat att gtg cta act cag tct         98
Leu Phe Trp Ile Ser Ala Ser Arg Gly Asp Ile Val Leu Thr Gln Ser           
            15                  20                  25                    

cca gcc acc ctg tct gtg act cca gga gat aga gtc agt ctt tcc tgc        146
Pro Ala Thr Leu Ser Val Thr Pro Gly Asp Arg Val Ser Leu Ser Cys           
        30                  35                  40                        

agg gcc agt caa agt att agc aac tac cta cac tgg tat caa caa aaa        194
Arg Ala Ser Gln Ser Ile Ser Asn Tyr Leu His Trp Tyr Gln Gln Lys           
    45                  50                  55                            

tca cat gag tct cca agg ctt ctc atc aag tat gct tcc cag tcc atc        242
Ser His Glu Ser Pro Arg Leu Leu Ile Lys Tyr Ala Ser Gln Ser Ile           
60                  65                  70                  75            

tct ggg atc ccc tcc agg ttc agt ggc agt gga tca ggg aca gat ttc        290
Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe           
                80                  85                  90                

att ctc agt ttc aac agt gtg gag act gaa gat ttt gga atg tat ttc        338
Ile Leu Ser Phe Asn Ser Val Glu Thr Glu Asp Phe Gly Met Tyr Phe           
            95                  100                 105                   

tgt caa cag agt aac agc tgg cct ttc acg ttc ggc tcg ggg aca aaa        386
Cys Gln Gln Ser Asn Ser Trp Pro Phe Thr Phe Gly Ser Gly Thr Lys           
        110                 115                 120                       

ttg gaa ata aaa cgg                                                    401
Leu Glu Ile Lys Arg                                                       
    125                                                                   


<210>  42
<211>  128
<212>  PRT
<213>  Mus musculus

<400>  42

Met Val Phe Thr Pro Gln Ile Leu Gly Leu Met Leu Phe Trp Ile Ser 
1               5                   10                  15      


Ala Ser Arg Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Val Thr Pro Gly Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Ile Ser Asn Tyr Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro 
    50                  55                  60                  


Arg Leu Leu Ile Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ile Leu Ser Phe Asn 
                85                  90                  95      


Ser Val Glu Thr Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln Ser Asn 
            100                 105                 110         


Ser Trp Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


<210>  43
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized sequence


<220>
<221>  CDS
<222>  (1)..(321)

<400>  43
cag tct gcc ctg act cag tcc cca gca act ctc tct gtg tct ccc ggc         48
Gln Ser Ala Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly           
1               5                   10                  15                

caa tct gtg agc ctg tcc tgt cgg gca agc cag tct att tcc aat tat         96
Gln Ser Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn Tyr           
            20                  25                  30                    

ctg cac tgg tat cag caa cac cca ggc gag agc cca cgg ctc ctg atc        144
Leu His Trp Tyr Gln Gln His Pro Gly Glu Ser Pro Arg Leu Leu Ile           
        35                  40                  45                        

aaa tac gcc tct caa tcc att tct ggc tcc aac aga cgc ttc tct ggc        192
Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ser Asn Arg Arg Phe Ser Gly           
    50                  55                  60                            

agc ggc tcc ggc acc gat ttc att ctc agc ttt aat agc gtt cag gca        240
Ser Gly Ser Gly Thr Asp Phe Ile Leu Ser Phe Asn Ser Val Gln Ala           
65                  70                  75                  80            

gag gat ttt ggg atg tac ttc tgt caa cag agc aac tct tgg cct ttt        288
Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro Phe           
                85                  90                  95                

acc ttc gga agc ggg act aaa ctg acc gtt ctg                            321
Thr Phe Gly Ser Gly Thr Lys Leu Thr Val Leu                               
            100                 105                                       


<210>  44
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  44

Gln Ser Ala Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Gln Ser Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln His Pro Gly Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ser Asn Arg Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ile Leu Ser Phe Asn Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Thr Val Leu 
            100                 105         


<210>  45
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized sequence


<220>
<221>  CDS
<222>  (1)..(321)

<400>  45
caa tct gca ctg act caa tct cca gca aca ctg tcc gtt tct cct gga         48
Gln Ser Ala Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly           
1               5                   10                  15                

caa tcc gtg agc ctc agc tgt agg gca tcc cag tcc att agc aac tat         96
Gln Ser Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn Tyr           
            20                  25                  30                    

ctc cac tgg tac cag cag cac cca gga gaa agc cct cgc ctg ctg ata        144
Leu His Trp Tyr Gln Gln His Pro Gly Glu Ser Pro Arg Leu Leu Ile           
        35                  40                  45                        

aaa tac gca agc cag tct att agc ggc agc aac cgg cgc ttc agc ggg        192
Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ser Asn Arg Arg Phe Ser Gly           
    50                  55                  60                            

tcc ggc tcc ggg aca gac ttt atc ctg tct ttt agc agc gtg caa gcc        240
Ser Gly Ser Gly Thr Asp Phe Ile Leu Ser Phe Ser Ser Val Gln Ala           
65                  70                  75                  80            

gaa gac ttt ggc atg tac ttc tgc cag cag tct aac aat tgg cca ttc        288
Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln Ser Asn Asn Trp Pro Phe           
                85                  90                  95                

acc ttc gga tcc ggc aca aag ctg acc gtg ctg                            321
Thr Phe Gly Ser Gly Thr Lys Leu Thr Val Leu                               
            100                 105                                       


<210>  46
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  46

Gln Ser Ala Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Gln Ser Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln His Pro Gly Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ser Asn Arg Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ile Leu Ser Phe Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln Ser Asn Asn Trp Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Thr Val Leu 
            100                 105         


<210>  47
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized sequence


<220>
<221>  CDS
<222>  (1)..(342)

<400>  47
cag gtt act ctg aaa gaa tct ggc cca act ctg gtt aag cct aca cag         48
Gln Val Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln           
1               5                   10                  15                

acc ctg tcc ctc acc tgt tct ttc tcc ggc ttt agc ctg agc aca agc         96
Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser           
            20                  25                  30                    

gga atg ggc gtc agc tgg atc aga caa cca ccc ggc aag ggc ctg gag        144
Gly Met Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu           
        35                  40                  45                        

tgg ctg gcc cac atc tat tgg gat gat gat aag agg tat aac cct tcc        192
Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser           
    50                  55                  60                            

ctg aaa tcc aga ctc aca att tcc aag gac acc tcc agc aac cag gtc        240
Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser Asn Gln Val           
65                  70                  75                  80            

ttc ctg aag ata acc tct gtt gat cca gtg gac acc gca act tac tac        288
Phe Leu Lys Ile Thr Ser Val Asp Pro Val Asp Thr Ala Thr Tyr Tyr           
                85                  90                  95                

tgc gcc cgc gac tac tat gcc agc tct ttt gac tac tgg ggg cag ggc        336
Cys Ala Arg Asp Tyr Tyr Ala Ser Ser Phe Asp Tyr Trp Gly Gln Gly           
            100                 105                 110                   

aca ctc                                                                342
Thr Leu                                                                   
                                                                          


<210>  48
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  48

Gln Val Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Thr Ser Val Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Tyr Tyr Ala Ser Ser Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu 
        


<210>  49
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized sequence


<220>
<221>  CDS
<222>  (1)..(342)

<400>  49
cag gtg act ctc aaa gaa tct ggc cct aca ctg gtg aaa ccc act cag         48
Gln Val Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln           
1               5                   10                  15                

aca ctc agc ctg acc tgc tcc ttc agc ggc ttc tct ctg agc act tcc         96
Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser           
            20                  25                  30                    

gga ctc gga gtg agc tgg att cgc caa cct cct ggg aaa ggc ctg gag        144
Gly Leu Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu           
        35                  40                  45                        

tgg ctg gca cac ata tac tgg gat gac gac aaa cgc tat aac cct agc        192
Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser           
    50                  55                  60                            

ctg aag tcc aga ctc aca atc tcc aaa gat aca tcc agc aat cag gtg        240
Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser Asn Gln Val           
65                  70                  75                  80            

ttt ctg aag atc acc tcc gtc gat cca gtc gac acc gcc act tac tat        288
Phe Leu Lys Ile Thr Ser Val Asp Pro Val Asp Thr Ala Thr Tyr Tyr           
                85                  90                  95                

tgt gct cgc gat tac tat gcc agc tcc ttc gac tac tgg gga cag gga        336
Cys Ala Arg Asp Tyr Tyr Ala Ser Ser Phe Asp Tyr Trp Gly Gln Gly           
            100                 105                 110                   

aca ctg                                                                342
Thr Leu                                                                   
                                                                          


<210>  50
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  50

Gln Val Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Leu Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Thr Ser Val Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Tyr Tyr Ala Ser Ser Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu 
        


<210>  51
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized sequence


<220>
<221>  CDS
<222>  (1)..(342)

<400>  51
cag gtc aca ctc aaa gaa tct gga cca aca ctc gtt aaa cca act caa         48
Gln Val Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln           
1               5                   10                  15                

aca ctc agc ctg act tgc agc ttt tct ggc ttc agc ctc tcc act agc         96
Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser           
            20                  25                  30                    

ggc ctc ggc gtg tcc tgg atc cgg cag ccc cct gga aaa ggc ctg gag        144
Gly Leu Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu           
        35                  40                  45                        

tgg ctg gcc cac atc tat tgg gac gat gac aag cgg tac aat cca agc        192
Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser           
    50                  55                  60                            

ctg aaa tct cgg ctg acc ata tct aag gat act tct tcc aat cag gtg        240
Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser Asn Gln Val           
65                  70                  75                  80            

ttc ctg aag atc aca tct gtg gct cct gtc gac act gcc act tat tat        288
Phe Leu Lys Ile Thr Ser Val Ala Pro Val Asp Thr Ala Thr Tyr Tyr           
                85                  90                  95                

tgc gca agg gat tac tac gca tcc tcc ttc gat tac tgg ggc cag gga        336
Cys Ala Arg Asp Tyr Tyr Ala Ser Ser Phe Asp Tyr Trp Gly Gln Gly           
            100                 105                 110                   

act ctg                                                                342
Thr Leu                                                                   
                                                                          


<210>  52
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  52

Gln Val Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Leu Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Thr Ser Val Ala Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Tyr Tyr Ala Ser Ser Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu 
        


<210>  53
<211>  648
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(648)

<400>  53
cag agc gaa ttg act cag cca ccc tca gcg tct ggg acc ccc ggg cag         48
Gln Ser Glu Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln           
1               5                   10                  15                

agg gtc acc atc tct tgt tct gga ggc tac tcc aac atg gga agc aat         96
Arg Val Thr Ile Ser Cys Ser Gly Gly Tyr Ser Asn Met Gly Ser Asn           
            20                  25                  30                    

tat gca cac tgg tac cag cag ctc cca gga acg gcc ccc aaa ctc ctc        144
Tyr Ala His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu           
        35                  40                  45                        

atc tat aac aat aat cag cgg ccc tca ggg gtc cct gac cga ttc tct        192
Ile Tyr Asn Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser           
    50                  55                  60                            

ggc tcc aag tct ggc acc tca gcc tcc ctg gcc atc agt ggg ctc cgg        240
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg           
65                  70                  75                  80            

tcc gag gat gag gct gat tat tac tgt gca gca tgg gat gac agc ctg        288
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu           
                85                  90                  95                

agt ggt ccg gtg ttc ggc gga ggg acc aag ctg acc gtc cta ggt cag        336
Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln           
            100                 105                 110                   

ccc aag gct gcc ccc tcg gtc act ctg ttc ccg ccc tcc tct gag gag        384
Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu           
        115                 120                 125                       

ctt caa gcc aac aag gcc aca ctg gtg tgt ctg atc agt gac ttc tac        432
Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr           
    130                 135                 140                           

ccg gga gct gtg aca gtg gcc tgg aag gca gat ggc agc ccc gtc aag        480
Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys           
145                 150                 155                 160           

gcg gga gtg gag acc acc aca ccc tcc aaa caa agc aac aac aag tac        528
Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr           
                165                 170                 175               

gcg gcc agc agc tat ctg agc ctg acg cct gag cag tgg aag tcc cac        576
Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His           
            180                 185                 190                   

aga agc tac agc tgc cag gtc acg cat gaa ggg agc acc gtg gag aag        624
Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys           
        195                 200                 205                       

aca gtg gcc cct aca gaa tgt tca                                        648
Thr Val Ala Pro Thr Glu Cys Ser                                           
    210                 215                                               


<210>  54
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  54

Gln Ser Glu Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Gly Tyr Ser Asn Met Gly Ser Asn 
            20                  25                  30          


Tyr Ala His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asn Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  55
<211>  411
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(411)

<400>  55
gaa gtt caa ttg tta gag tct ggt ggc ggt ctt gtt cag cct ggt ggt         48
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly           
1               5                   10                  15                

tct tta cgt ctt tct tgc gct gct tcc gga ttc act ttc tct cct tac         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Pro Tyr           
            20                  25                  30                    

tgg atg ggt tgg gtt cgc caa gct cct ggt aaa ggt ttg gag tgg gtt        144
Trp Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

tct gtt atc tgg cct tct ggt ggc act act gat tat gct gac tcc gtt        192
Ser Val Ile Trp Pro Ser Gly Gly Thr Thr Asp Tyr Ala Asp Ser Val           
    50                  55                  60                            

aaa ggt cgc ttc act atc tct aga gac aac tct aag aat act ctc tac        240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr           
65                  70                  75                  80            

ttg cag atg aac agc tta agg gct gag gac acg gcc gtg tat tac tgt        288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aga gtc cat cca gct ggc cac aac gac cac tgg ggc cag gga acc        336
Ala Arg Val His Pro Ala Gly His Asn Asp His Trp Gly Gln Gly Thr           
            100                 105                 110                   

ctg gtc acc gtc tca agc gcc tcc acc aag ggc cca tcg gtc ttc ccg        384
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro           
        115                 120                 125                       

cta gca ccc tcc tcc aag agc acc tct                                    411
Leu Ala Pro Ser Ser Lys Ser Thr Ser                                       
    130                 135                                               


<210>  56
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  56

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Pro Tyr 
            20                  25                  30          


Trp Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Trp Pro Ser Gly Gly Thr Thr Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val His Pro Ala Gly His Asn Asp His Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135         


<210>  57
<211>  645
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(645)

<400>  57
caa gac atc cag atg acc cag tct cca tcc tcc ctg tct ttg tct cca         48
Gln Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Leu Ser Pro           
1               5                   10                  15                

ggg gaa aga gcc acc ctc tcc tgc agg gcc agt cag agt att aac aga         96
Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Asn Arg           
            20                  25                  30                    

aac tta ggc tgg tac cag cag aag cct ggc cag gct ccc agg ctc ctc        144
Asn Leu Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu           
        35                  40                  45                        

atc tat ggt gcg tcc acc agg gcc act ggt atc cca gcc agg ttc act        192
Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Thr           
    50                  55                  60                            

ggc agt ggg tct ggg aca gag ttc tct ctc acc atc agc agc ctg cag        240
Gly Ser Gly Ser Gly Thr Glu Phe Ser Leu Thr Ile Ser Ser Leu Gln           
65                  70                  75                  80            

tct gaa gat tat gca att tat tat tgt cag cag tat gat aac tgg ccg        288
Ser Glu Asp Tyr Ala Ile Tyr Tyr Cys Gln Gln Tyr Asp Asn Trp Pro           
                85                  90                  95                

atc atc ttc ggc caa ggg aca cga ctg gag att aaa gga act gtg gct        336
Ile Ile Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Gly Thr Val Ala           
            100                 105                 110                   

gca cca tct gtc ttc atc ttc ccg cca tct gat gag cag ttg aaa tct        384
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser           
        115                 120                 125                       

gga act gcc tct gtt gtg tgc ctg ctg aat aac ttc tat ccc aga gag        432
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu           
    130                 135                 140                           

gcc aaa gta cag tgg aag gtg gat aac gcc ctc caa tcg ggt aac tcc        480
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser           
145                 150                 155                 160           

cag gag agt gtc aca gag cag gac agc aag gac agc acc tac agc ctc        528
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu           
                165                 170                 175               

agc agc acc ctg acg ctg agc aaa gca gac tac gag aaa cac aaa gtc        576
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val           
            180                 185                 190                   

tac gcc tgc gaa gtc acc cat cag ggc ctg agc tcg ccc gtc aca aag        624
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys           
        195                 200                 205                       

agc ttc aac agg gga gag tgt                                            645
Ser Phe Asn Arg Gly Glu Cys                                               
    210                 215                                               


<210>  58
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  58

Gln Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Leu Ser Pro 
1               5                   10                  15      


Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Asn Arg 
            20                  25                  30          


Asn Leu Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Thr 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Glu Phe Ser Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Tyr Ala Ile Tyr Tyr Cys Gln Gln Tyr Asp Asn Trp Pro 
                85                  90                  95      


Ile Ile Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Gly Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  59
<211>  411
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(411)

<400>  59
gaa gtt caa ttg tta gag tct ggt ggc ggt ctt gtt cag cct ggt ggt         48
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly           
1               5                   10                  15                

tct tta cgt ctt tct tgc gct gct tcc gga ttc act ttc tct cgt tac         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr           
            20                  25                  30                    

ttt atg aag tgg gtt cgc caa gct cct ggt aaa ggt ttg gag tgg gtt        144
Phe Met Lys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

tct tgg atc tct cct tct ggt ggc ctt act gag tat gct gac tcc gtt        192
Ser Trp Ile Ser Pro Ser Gly Gly Leu Thr Glu Tyr Ala Asp Ser Val           
    50                  55                  60                            

aaa ggt cgc ttc act atc tct aga gac aac tct aag aat act ctc tac        240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr           
65                  70                  75                  80            

ttg cag atg aac agc tta agg gct gag gac acg gcc gtg tat tac tgt        288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcc aga gcc tca tac ggt gcc tgg ctg gac tac tgg ggc cag ggc acc        336
Ala Arg Ala Ser Tyr Gly Ala Trp Leu Asp Tyr Trp Gly Gln Gly Thr           
            100                 105                 110                   

ctg gtc acc gtc tca agc gcc tcc acc aag ggc cca tcg gtc ttc ccg        384
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro           
        115                 120                 125                       

cta gca ccc tcc tcc aag agc acc tct                                    411
Leu Ala Pro Ser Ser Lys Ser Thr Ser                                       
    130                 135                                               


<210>  60
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  60

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Phe Met Lys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Trp Ile Ser Pro Ser Gly Gly Leu Thr Glu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Ser Tyr Gly Ala Trp Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135         


<210>  61
<211>  651
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(651)

<400>  61
cag agc gtc ttg act cag cca ccc tca gcg tct ggg acc ccc ggc cag         48
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln           
1               5                   10                  15                

ggg gtc acc atc tct tgt tct gga agc agc tcc aac atc gga agt aat         96
Gly Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn           
            20                  25                  30                    

agt gtt aac tgg tac cag cag ctc cca gga gcg gcc ccc aaa ctc ctc        144
Ser Val Asn Trp Tyr Gln Gln Leu Pro Gly Ala Ala Pro Lys Leu Leu           
        35                  40                  45                        

atc tat agt aac aat ctg cgg ccc tca ggg gtc cct gcc cga ttc tct        192
Ile Tyr Ser Asn Asn Leu Arg Pro Ser Gly Val Pro Ala Arg Phe Ser           
    50                  55                  60                            

ggc tcc aag tct ggc acc tca gcc tcc ctg gcc atc agt ggc ctc cgg        240
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg           
65                  70                  75                  80            

tct gag gat gag gct gat tat tac tgt gca gcc tgg gat gac ggc ctg        288
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Gly Leu           
                85                  90                  95                

gat gcc tat gtg gtg ttc ggc gga ggg acc aaa ctg acc gtc ctg ggt        336
Asp Ala Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly           
            100                 105                 110                   

cag ccc aag gcc aac ccc act gtc act ctg ttc ccg ccc tcc tct gag        384
Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu           
        115                 120                 125                       

gag ctc caa gcc aac aag gcc aca cta gtg tgt ctg atc agt gac ttc        432
Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe           
    130                 135                 140                           

tac ccg gga gct gtg aca gtg gcc tgg aag gca gat ggc agc ccc gtc        480
Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val           
145                 150                 155                 160           

aag gcg gga gtg gag acc acc aaa ccc tcc aaa cag agc aac aac aag        528
Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys           
                165                 170                 175               

tac gcg gcc agc agc tac ctg agc ctg acg ccc gag cag tgg aag tcc        576
Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser           
            180                 185                 190                   

cac aga agc tac agc tgc cag gtc acg cat gaa ggg agc acc gtg gag        624
His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu           
        195                 200                 205                       

aag aca gtg gcc cct gca gaa tgc tct                                    651
Lys Thr Val Ala Pro Ala Glu Cys Ser                                       
    210                 215                                               


<210>  62
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  62

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Gly Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Ser Val Asn Trp Tyr Gln Gln Leu Pro Gly Ala Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asn Asn Leu Arg Pro Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Gly Leu 
                85                  90                  95      


Asp Ala Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Ala Glu Cys Ser 
    210                 215         


<210>  63
<211>  414
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(414)

<400>  63
gaa gtt caa ttg tta gag tct ggt ggc ggt ctt gtt cag cct ggt ggt         48
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly           
1               5                   10                  15                

tct tta cgt ctt tct tgc gct gct tcc gga ttc act ttc tct act tac         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr           
            20                  25                  30                    

tgg atg gct tgg gtt cgc caa gct cct ggt aaa ggt ttg gag tgg gtt        144
Trp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

tct gtt atc ggt cct tct ggt ggc atg act gtt tat gct gac tcc gtt        192
Ser Val Ile Gly Pro Ser Gly Gly Met Thr Val Tyr Ala Asp Ser Val           
    50                  55                  60                            

aaa ggt cgc ttc act atc tct aga gac aac tct aag aat act ctc tac        240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr           
65                  70                  75                  80            

ttg cag atg aac agc tta agg gct gag gac acg gcc gtg tat tac tgt        288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gca cgg att aat agt ggg agc tcc cac ttt gac tac tgg ggc cag gga        336
Ala Arg Ile Asn Ser Gly Ser Ser His Phe Asp Tyr Trp Gly Gln Gly           
            100                 105                 110                   

acc ctg gtc acc gtc tca agc gcc tcc acc aag ggc cca tcg gtc ttc        384
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe           
        115                 120                 125                       

ccg cta gca ccc tcc tcc aag agc acc tct                                414
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser                                   
    130                 135                                               


<210>  64
<211>  138
<212>  PRT
<213>  Homo sapiens

<400>  64

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Trp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Gly Pro Ser Gly Gly Met Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Asn Ser Gly Ser Ser His Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135             


<210>  65
<211>  651
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(651)

<400>  65
cag tac gaa ttg act cag cca ccc tca gcg tct ggg acc ccc ggg cag         48
Gln Tyr Glu Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln           
1               5                   10                  15                

agg gtc acc atc tct tgt tct gga agc agc tcc aac atc gga agc aat         96
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn           
            20                  25                  30                    

att gta cac tgg tac cag cag ctc cca gga acg gcc ccc aaa ctc ctc        144
Ile Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu           
        35                  40                  45                        

ata tat ggt aat aat cag cgg ccc tca ggg gtc cct gac cga ttc tct        192
Ile Tyr Gly Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser           
    50                  55                  60                            

gtc tcc aag tct ggc tcc tca gcc tcc ctg gcc atc agt ggg ctc cag        240
Val Ser Lys Ser Gly Ser Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln           
65                  70                  75                  80            

tct gag gat gag gct gat tat tac tgt gca tca tgg gat gac agc ctg        288
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Trp Asp Asp Ser Leu           
                85                  90                  95                

aaa gcc ttt tat gtc ttc gga act ggg acc aag gtc acc gtc cta ggt        336
Lys Ala Phe Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly           
            100                 105                 110                   

cag ccc aag gcc aac ccc act gtc act ctg ttc ccg ccc tcc tct gag        384
Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu           
        115                 120                 125                       

gag ctc caa gcc aac aag gcc aca cta gtg tgt ctg atc agt gac ttc        432
Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe           
    130                 135                 140                           

tac ccg gga gct gtg aca gtg gcc tgg aag gca gat ggc agc ccc gtc        480
Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val           
145                 150                 155                 160           

aag gcg gga gtg gag acc acc aaa ccc tcc aaa cag agc aac aac aag        528
Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys           
                165                 170                 175               

tac gcg gcc agc agc tac ctg agc ctg acg ccc gag cag tgg aag tcc        576
Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser           
            180                 185                 190                   

cac aga agc tac agc tgc cag gtc acg cat gaa ggg agc acc gtg gag        624
His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu           
        195                 200                 205                       

aag aca gtg gcc cct aca gaa tgt tca                                    651
Lys Thr Val Ala Pro Thr Glu Cys Ser                                       
    210                 215                                               


<210>  66
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  66

Gln Tyr Glu Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Ile Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Val Ser Lys Ser Gly Ser Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Trp Asp Asp Ser Leu 
                85                  90                  95      


Lys Ala Phe Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  67
<211>  420
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(420)

<400>  67
gaa gtt caa ttg tta gag tct ggt ggc ggt ctt gtt cag cct ggt ggt         48
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly           
1               5                   10                  15                

tct tta cgt ctt tct tgc gct gct tcc gga ttc act ttc tct cat tac         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr           
            20                  25                  30                    

tgg atg ggt tgg gtt cgc caa gct cct ggt aaa ggt ttg gag tgg gtt        144
Trp Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

tct gtt atc tct cct tct ggt ggc ctt act att tat gct gac tcc gtt        192
Ser Val Ile Ser Pro Ser Gly Gly Leu Thr Ile Tyr Ala Asp Ser Val           
    50                  55                  60                            

aaa ggt cgc ttc act atc tct aga gac aac tct aag aat act ctc tac        240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr           
65                  70                  75                  80            

ttg cag atg aac agc tta agg gct gag gac acg gcc gtg tat tac tgt        288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gca cgg agc agt ggc tgg gct ctg gat gct ttt gat atc tgg ggc caa        336
Ala Arg Ser Ser Gly Trp Ala Leu Asp Ala Phe Asp Ile Trp Gly Gln           
            100                 105                 110                   

ggg aca atg gtc acc gtc tca agc gcc tcc acc aag ggc cca tcg gtc        384
Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val           
        115                 120                 125                       

ttc ccg cta gca ccc tcc tcc aag agc acc tct ggg                        420
Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly                           
    130                 135                 140                           


<210>  68
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  68

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Trp Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Pro Ser Gly Gly Leu Thr Ile Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Ser Gly Trp Ala Leu Asp Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140 


<210>  69
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sens primer

<400>  69
ggccagtctc accactgacc                                                   20


<210>  70
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer

<400>  70
tgctggagtc aggctgtcac                                                   20


<210>  71
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  71

Gly Phe Ser Leu Ser Thr Ser Gly Met Gly Val Ser 
1               5                   10          


<210>  72
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  72

His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Ser Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  73
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  73

Ala Arg Asp Tyr Tyr Ala Ser Ser Phe Asp Tyr 
1               5                   10      


<210>  74
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VARIABLE REGION HC

<400>  74

Gln Val Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Tyr Tyr Ala Ser Ser Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  75

<400>  75
000

<210>  76
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HEAVY CHAIN


<220>
<221>  CDS
<222>  (1)..(1338)

<400>  76
cag gtc aca ctg aaa gag tcc ggc ccc acc ctg gtc aag ccc acc cag         48
Gln Val Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln           
1               5                   10                  15                

acc ctg acc ctg aca tgc acc ttc agc ggc ttc agc ctg agc acc agc         96
Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser           
            20                  25                  30                    

ggc atg ggc gtg tcc tgg atc aga cag ccc cct ggc aag gcc ctg gaa        144
Gly Met Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu           
        35                  40                  45                        

tgg ctg gcc cac atc tac tgg gac gac gac aag cgg tac agc ccc agc        192
Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Ser Pro Ser           
    50                  55                  60                            

ctg aag tcc cgg ctg acc atc acc aag gac acc agc aag aac cag gtg        240
Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val           
65                  70                  75                  80            

gtg ctg acc atg aca aac atg gac ccc gtg gac acc gcc acc tac tac        288
Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr           
                85                  90                  95                

tgc gcc aga gac tac tac gcc agc agc ttc gac tac tgg ggc cag ggc        336
Cys Ala Arg Asp Tyr Tyr Ala Ser Ser Phe Asp Tyr Trp Gly Gln Gly           
            100                 105                 110                   

acc acc ctg acc gtg tcc agc gct tcc acc aag ggc cct tcc gtg ttc        384
Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe           
        115                 120                 125                       

cct ctg gcc cct tgc tcc cgg tcc acc tcc gag tcc acc gcc gct ctg        432
Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu           
    130                 135                 140                           

ggc tgc ctg gtg aag gac tac ttc cct gag cct gtg acc gtg tcc tgg        480
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp           
145                 150                 155                 160           

aac tct ggc gcc ctg acc tcc ggc gtg cac acc ttc cct gcc gtg ctg        528
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu           
                165                 170                 175               

cag tcc tcc ggc ctg tac tcc ctg tcc tcc gtg gtg acc gtg cct tcc        576
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser           
            180                 185                 190                   

tcc tcc ctg ggc acc aag acc tac acc tgt aac gtg gac cac aag cct        624
Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro           
        195                 200                 205                       

tcc aac acc aag gtg gac aag cgg gtg gag tcc aag tac ggc cct cct        672
Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro           
    210                 215                 220                           

tgc cct ccc tgc cct gcc cct gag ttc gag ggc gga cct agc gtg ttc        720
Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe           
225                 230                 235                 240           

ctg ttc cct cct aag cct aag gac acc ctg atg atc tcc cgg acc cct        768
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro           
                245                 250                 255               

gag gtg acc tgt gtg gtg gtg gac gtg tcc cag gag gac cct gag gtc        816
Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val           
            260                 265                 270                   

cag ttc aac tgg tac gtg gac ggc gtg gag gtg cac aac gcc aag acc        864
Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr           
        275                 280                 285                       

aag cct cgg gag gag cag ttc aat tcc acc tac cgg gtg gtg tct gtg        912
Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val           
    290                 295                 300                           

ctg acc gtg ctg cac cag gac tgg ctg aac ggc aaa gaa tac aag tgt        960
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys           
305                 310                 315                 320           

aag gtc tcc aac aag ggc ctg ccc tcc tcc atc gag aaa acc atc tcc       1008
Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser           
                325                 330                 335               

aag gcc aag ggc cag cct agg gag cct cag gtg tac acc ctg cct cct       1056
Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro           
            340                 345                 350                   

agc cag gaa gag atg acc aag aac cag gtg tcc ctg acc tgt ctg gtg       1104
Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val           
        355                 360                 365                       

aag ggc ttc tac cct tcc gac atc gcc gtg gag tgg gag tcc aac ggc       1152
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly           
    370                 375                 380                           

cag cct gag aac aac tac aag acc acc cct cct gtg ctg gac tcc gac       1200
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp           
385                 390                 395                 400           

ggc tcc ttc ttc ctg tac tcc agg ctg acc gtg gac aag tcc cgg tgg       1248
Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp           
                405                 410                 415               

cag gag ggc aac gtc ttt tcc tgc tcc gtg atg cac gag gcc ctg cac       1296
Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His           
            420                 425                 430                   

aac cac tac acc cag aag tcc ctg tcc ctg tct ctg ggc tga               1338
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly                       
        435                 440                 445                       


<210>  77
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  77

Gln Val Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Tyr Tyr Ala Ser Ser Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445 


<210>  78

<400>  78
000

<210>  79

<400>  79
000

<210>  80
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  80

Arg Ala Ser Gln Ser Ile Ser Tyr Tyr Leu His 
1               5                   10      


<210>  81
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  81

Tyr Ala Ser Leu Ser Ile Ser 
1               5           


<210>  82
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  82

Gln Gln Ser Asp Ser Trp Pro Phe Thr 
1               5                   


<210>  83
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VARIABLE REGION LC

<400>  83

Asp Ile Val Leu Thr Gln Ser Pro Ala Phe Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Tyr Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Asp Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Leu Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asp Ser Trp Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  84
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LIGHT CHAIN


<220>
<221>  CDS
<222>  (1)..(645)

<400>  84
gac atc gtg ctg acc cag agc ccc gcc ttc ctg agc gtg acc cct ggc         48
Asp Ile Val Leu Thr Gln Ser Pro Ala Phe Leu Ser Val Thr Pro Gly           
1               5                   10                  15                

gag aaa gtg acc atc acc tgt cgg gcc agc cag agc atc agc tac tac         96
Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Tyr Tyr           
            20                  25                  30                    

ctg cac tgg tat cag cag aag ccc gac cag gcc ccc aag ctg ctg att        144
Leu His Trp Tyr Gln Gln Lys Pro Asp Gln Ala Pro Lys Leu Leu Ile           
        35                  40                  45                        

aag tac gcc agc ctg tcc atc agc ggc gtg ccc agc aga ttc agc ggc        192
Lys Tyr Ala Ser Leu Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly           
    50                  55                  60                            

agc ggc tcc ggc acc gac ttc acc ttc acc atc agc agc ctg gaa gcc        240
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Glu Ala           
65                  70                  75                  80            

gag gac gcc gcc acc tac tac tgc cag cag agc gac agc tgg ccc ttc        288
Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asp Ser Trp Pro Phe           
                85                  90                  95                

acc ttc ggc cag ggc acc aaa ctg gaa atc aag cgt acg gtg gcc gct        336
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala           
            100                 105                 110                   

cct tcc gtg ttc atc ttc cct ccc tcc gac gag cag ctg aag tcc ggc        384
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly           
        115                 120                 125                       

acc gcc tcc gtg gtg tgt ctg ctg aac aac ttc tac cct cgg gag gcc        432
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala           
    130                 135                 140                           

aag gtg cag tgg aag gtg gac aac gcc ctg cag tcc ggc aac tcc cag        480
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln           
145                 150                 155                 160           

gag tcc gtc acc gag cag gac tcc aag gac agc acc tac tcc ctg tcc        528
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser           
                165                 170                 175               

tcc acc ctg acc ctg tcc aag gcc gac tac gag aag cac aag gtg tac        576
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr           
            180                 185                 190                   

gcc tgt gag gtg acc cac cag ggc ctg tcc agc cct gtg acc aag tcc        624
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser           
        195                 200                 205                       

ttc aac cgg ggc gag tgc tga                                            645
Phe Asn Arg Gly Glu Cys                                                   
    210                                                                   


<210>  85
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  85

Asp Ile Val Leu Thr Gln Ser Pro Ala Phe Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Tyr Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Asp Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Leu Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asp Ser Trp Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  86
<211>  1329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LIGHT CHAIN


<220>
<221>  CDS
<222>  (1)..(1329)

<400>  86
caa gtg acc ctg aaa gag tcc ggc ccc acc ctc gtg aag cct acc cag         48
Gln Val Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln           
1               5                   10                  15                

acc ctg aca ctg acc tgc acc ttc agc ggc ttc agc ctg agc aca agc         96
Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser           
            20                  25                  30                    

ggc atg ggc gtg tcc tgg atc aga cag cct cct ggc aag gcc ctg gaa        144
Gly Met Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu           
        35                  40                  45                        

tgg ctg gcc cac atc tac tgg gac gac gac aag cgg tac agc ccc agc        192
Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Ser Pro Ser           
    50                  55                  60                            

ctg aag tcc cgg ctg acc atc acc aag gac acc agc aag aac cag gtg        240
Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val           
65                  70                  75                  80            

gtg ctg acc atg aca aac atg gac ccc gtg gac acc gcc acc tac tac        288
Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr           
                85                  90                  95                

tgc gcc aga gac tac tac gcc agc agc ttc gac tac tgg ggc cag ggc        336
Cys Ala Arg Asp Tyr Tyr Ala Ser Ser Phe Asp Tyr Trp Gly Gln Gly           
            100                 105                 110                   

aca acc ctg acc gtg tct agc gcc aag acc acc ccc cct agc gtg tac        384
Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr           
        115                 120                 125                       

cct ctg gcc cct gga tct gcc gcc cag acc aat agc atg gtc acc ctg        432
Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu           
    130                 135                 140                           

ggc tgc ctc gtg aaa ggc tac ttc ccc gag cct gtg acc gtg acc tgg        480
Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp           
145                 150                 155                 160           

aac agc ggc tct ctg tct agc ggc gtg cac acc ttt cca gcc gtg ctg        528
Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu           
                165                 170                 175               

cag agc gac ctg tac acc ctg agc agc agc gtg acc gtg cca agc agc        576
Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser           
            180                 185                 190                   

acc tgg cct agc gag act gtg acc tgc aac gtg gcc cac cct gcc agc        624
Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser           
        195                 200                 205                       

agc aca aag gtg gac aag aaa atc gtg ccc cgg gac tgc ggc tgc aag        672
Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys           
    210                 215                 220                           

ccc tgt atc tgt acc gtg ccc gag gtg tcc agc gtg ttc atc ttc cca        720
Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro           
225                 230                 235                 240           

ccc aag ccc aag gac gtg ctg aca atc acc ctg acc ccc aaa gtg acc        768
Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr           
                245                 250                 255               

tgc gtg gtg gtg gac atc agc aag gac gac ccc gag gtg cag ttc tct        816
Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser           
            260                 265                 270                   

tgg ttt gtg gac gac gtg gaa gtg cac aca gcc cag acc cag ccc aga        864
Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg           
        275                 280                 285                       

gag gaa cag ttc aac tcc acc ttc aga agc gtg tcc gag ctg ccc atc        912
Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile           
    290                 295                 300                           

atg cac cag gac tgg ctg aac ggc aaa gaa ttc aag tgc aga gtg aac        960
Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn           
305                 310                 315                 320           

agc gcc gcc ttc cct gcc ccc atc gag aaa acc atc tcc aag acc aag       1008
Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys           
                325                 330                 335               

ggc aga ccc aag gcc ccc cag gtg tac aca atc ccc cca ccc aaa gaa       1056
Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu           
            340                 345                 350                   

cag atg gcc aag gac aag gtg tcc ctg acc tgt atg atc acc gat ttc       1104
Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe           
        355                 360                 365                       

ttc cca gag gac atc acc gtg gaa tgg cag tgg aac ggc cag ccc gcc       1152
Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala           
    370                 375                 380                           

gag aac tac aag aac acc cag cct atc atg gac acc gac ggc agc tac       1200
Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr           
385                 390                 395                 400           

ttc gtg tac tcc aag ctg aac gtg cag aag tcc aac tgg gag gcc ggc       1248
Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly           
                405                 410                 415               

aac acc ttt acc tgc agc gtg ctg cac gag ggc ctg cac aac cac cac       1296
Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His His           
            420                 425                 430                   

acc gag aag tcc ctg agc cac agc cct ggc tga                           1329
Thr Glu Lys Ser Leu Ser His Ser Pro Gly                                   
        435                 440                                           


<210>  87
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  87

Gln Val Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Tyr Tyr Ala Ser Ser Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr 
        115                 120                 125             


Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp 
145                 150                 155                 160 


Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser 
            180                 185                 190         


Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser 
        195                 200                 205             


Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys 
    210                 215                 220                 


Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser 
            260                 265                 270         


Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg 
        275                 280                 285             


Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile 
    290                 295                 300                 


Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn 
305                 310                 315                 320 


Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys 
                325                 330                 335     


Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu 
            340                 345                 350         


Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe 
        355                 360                 365             


Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala 
    370                 375                 380                 


Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr 
385                 390                 395                 400 


Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly 
                405                 410                 415     


Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His His 
            420                 425                 430         


Thr Glu Lys Ser Leu Ser His Ser Pro Gly 
        435                 440         


<210>  88
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC


<220>
<221>  CDS
<222>  (1)..(645)

<400>  88
gac atc gtg ctg acc cag agc cct gcc ttc ctg agc gtg acc cct ggc         48
Asp Ile Val Leu Thr Gln Ser Pro Ala Phe Leu Ser Val Thr Pro Gly           
1               5                   10                  15                

gag aaa gtg acc atc acc tgt cgg gcc agc cag agc atc agc tac tac         96
Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Tyr Tyr           
            20                  25                  30                    

ctg cac tgg tat cag cag aag ccc gac cag gcc ccc aag ctg ctg att        144
Leu His Trp Tyr Gln Gln Lys Pro Asp Gln Ala Pro Lys Leu Leu Ile           
        35                  40                  45                        

aag tac gcc agc ctg tcc atc agc ggc gtg ccc agc aga ttt tct ggc        192
Lys Tyr Ala Ser Leu Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly           
    50                  55                  60                            

tct ggc agc ggc acc gac ttc acc ttc acc atc agc agc ctg gaa gcc        240
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Glu Ala           
65                  70                  75                  80            

gag gac gcc gcc acc tac tac tgt cag cag agc gac tcc tgg cct ttc        288
Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asp Ser Trp Pro Phe           
                85                  90                  95                

acc ttc ggc cag ggc acc aag ctg gaa atc aag aga gcc gac gcc gct        336
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala           
            100                 105                 110                   

ccc acc gtg tcc atc ttt cca cct agc agc gag cag ctg acc agc ggc        384
Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly           
        115                 120                 125                       

gga gct agc gtc gtg tgc ttc ctg aac aac ttc tac ccc aag gac atc        432
Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile           
    130                 135                 140                           

aac gtg aag tgg aag atc gac ggc agc gag cgg cag aac ggc gtg ctg        480
Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu           
145                 150                 155                 160           

aat agc tgg acc gac cag gac agc aag gac tcc acc tac agc atg tcc        528
Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser           
                165                 170                 175               

agc acc ctg aca ctg acc aag gac gag tac gag cgg cac aac agc tac        576
Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr           
            180                 185                 190                   

aca tgc gag gcc acc cac aag acc agc acc agc ccc atc gtg aag tcc        624
Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser           
        195                 200                 205                       

ttc aac cgg aac gag tgc tga                                            645
Phe Asn Arg Asn Glu Cys                                                   
    210                                                                   


<210>  89
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  89

Asp Ile Val Leu Thr Gln Ser Pro Ala Phe Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Tyr Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Asp Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Leu Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asp Ser Trp Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala 
            100                 105                 110         


Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly 
        115                 120                 125             


Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu 
145                 150                 155                 160 


Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr 
            180                 185                 190         


Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser 
        195                 200                 205             


Phe Asn Arg Asn Glu Cys 
    210                 


<210>  90

<400>  90
000

<210>  91

<400>  91
000

<210>  92

<400>  92
000

<210>  93

<400>  93
000

<210>  94
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  94

Gln Ser Ile Ser Tyr Tyr 
1               5       


<210>  95
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  95

Gly Phe Ser Leu Ser Thr Ser Gly Met Gly 
1               5                   10  


<210>  96
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  96

Tyr Trp Asp Asp Asp Lys 
1               5       


<210>  97
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  97

Gln Ser Ile Ser Asn Tyr 
1               5       


<210>  98
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  98

Tyr Ala Ser 
1           


