                               SEQUENCE LISTING

<110> SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH
 
<120> TREATMENT OF TUMORS EXPRESSING MUTANT P53

<130> 2003080-0803

<140> PCT/US2015/010653
<141> 2015-01-08

<150> 61/925,278
<151> 2014-01-09

<160> 35    

<170> PatentIn version 3.5

<210> 1
<211> 2451
<212> DNA
<213> Homo sapiens

<400> 1
cgtgctttcc acgacggtga cacgcttccc tggattggcc agactgcctt ccgggtcact       60

gccatggagg agccgcagtc agatcctagc gtcgagcccc ctctgagtca ggaaacattt      120

tcagacctat ggaaactact tcctgaaaac aacgttctgt cccccttgcc gtcccaagca      180

atggatgatt tgatgctgtc cccggacgat attgaacaat ggttcactga agacccaggt      240

ccagatgaag ctcccagaat gccagaggct gctccccgcg tggcccctgc accagcagct      300

cctacaccgg cggcccctgc accagccccc tcctggcccc tgtcatcttc tgtcccttcc      360

cagaaaacct accagggcag ctacggtttc cgtctgggct tcttgcattc tgggacagcc      420

aagtctgtga cttgcacgta ctcccctgcc ctcaacaaga tgttttgcca actggccaag      480

acctgccctg tgcagctgtg ggttgattcc acacccccgc ccggcacccg cgtccgcgcc      540

atggccatct acaagcagtc acagcacatg acggaggttg tgaggcgctg cccccaccat      600

gagcgctgct cagatagcga tggtctggcc cctcctcagc atcttatccg agtggaagga      660

aatttgcgtg tggagtattt ggatgacaga aacacttttc gacatagtgt ggtggtgccc      720

tatgagccgc ctgaggttgg ctctgactgt accaccatcc actacaacta catgtgtaac      780

agttcctgca tgggcggcat gaaccggagg cccatcctca ccatcatcac actggaagac      840

tccagtggta atctactggg acggaacagc tttgaggtgc atgtttgtgc ctgtcctggg      900

agagaccggc gcacagagga agagaatctc cgcaagaaag gggagcctca ccacgagctg      960

cccccaggga gcactaagcg agcactgtcc aacaacacca gctcctctcc ccagccaaag     1020

aagaaaccac tggatggaga atatttcacc cttcagatcc gtgggcgtga gcgcttcgag     1080

atgttccgag agctgaatga ggccttggaa ctcaaggatg cccaggctgg gaaggagcca     1140

ggggggagca gggctcactc cagccacctg aagtccaaaa agggtcagtc tacctcccgc     1200

cataaaaaac tcatgttcaa gacagaaggg cctgactcag actgacattc tccacttctt     1260

gttccccact gacagcctcc cacccccatc tctccctccc ctgccatttt gggttttggg     1320

tctttgaacc cttgcttgca ataggtgtgc gtcagaagca cccaggactt ccatttgctt     1380

tgtcccgggg ctccactgaa caagttggcc tgcactggtg ttttgttgtg gggaggagga     1440

tggggagtag gacataccag cttagatttt aaggttttta ctgtgaggga tgtttgggag     1500

atgtaagaaa tgttcttgca gttaagggtt agtttacaat cagccacatt ctaggtaggg     1560

gcccacttca ccgtactaac cagggaagct gtccctcact gttgaatttt ctctaacttc     1620

aaggcccata tctgtgaaat gctggcattt gcacctacct cacagagtgc attgtgaggg     1680

ttaatgaaat aatgtacatc tggccttgaa accacctttt attacatggg gtctagaact     1740

tgaccccctt gagggtgctt gttccctctc cctgttggtc ggtgggttgg tagtttctac     1800

agttgggcag ctggttaggt agagggagtt gtcaagtctc tgctggccca gccaaaccct     1860

gtctgacaac ctcttggtga accttagtac ctaaaaggaa atctcacccc atcccacacc     1920

ctggaggatt tcatctcttg tatatgatga tctggatcca ccaagacttg ttttatgctc     1980

agggtcaatt tcttttttct tttttttttt ttttttcttt ttctttgaga ctgggtctcg     2040

ctttgttgcc caggctggag tggagtggcg tgatcttggc ttactgcagc ctttgcctcc     2100

ccggctcgag cagtcctgcc tcagcctccg gagtagctgg gaccacaggt tcatgccacc     2160

atggccagcc aacttttgca tgttttgtag agatggggtc tcacagtgtt gcccaggctg     2220

gtctcaaact cctgggctca ggcgatccac ctgtctcagc ctcccagagt gctgggatta     2280

caattgtgag ccaccacgtc cagctggaag ggtcaacatc ttttacattc tgcaagcaca     2340

tctgcatttt caccccaccc ttcccctcct tctccctttt tatatcccat ttttatatcg     2400

atctcttatt ttacaataaa actttgctgc caaaaaaaaa aaaaaaaaaa a              2451


<210> 2
<211> 393
<212> PRT
<213> Homo sapiens

<400> 2
Met Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln 
1               5                   10                  15      


Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu 
            20                  25                  30          


Ser Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp 
        35                  40                  45              


Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro 
    50                  55                  60                  


Arg Met Pro Glu Ala Ala Pro Arg Val Ala Pro Ala Pro Ala Ala Pro 
65                  70                  75                  80  


Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser Ser Ser 
                85                  90                  95      


Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly Phe Arg Leu Gly 
            100                 105                 110         


Phe Leu His Ser Gly Thr Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro 
        115                 120                 125             


Ala Leu Asn Lys Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln 
    130                 135                 140                 


Leu Trp Val Asp Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met 
145                 150                 155                 160 


Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys 
                165                 170                 175     


Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln 
            180                 185                 190         


His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp 
        195                 200                 205             


Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu 
    210                 215                 220                 


Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser 
225                 230                 235                 240 


Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr 
                245                 250                 255     


Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val 
            260                 265                 270         


Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn 
        275                 280                 285             


Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr 
    290                 295                 300                 


Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys 
305                 310                 315                 320 


Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu 
                325                 330                 335     


Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp 
            340                 345                 350         


Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Arg Ala His Ser Ser His 
        355                 360                 365             


Leu Lys Ser Lys Lys Gly Gln Ser Thr Ser Arg His Lys Lys Leu Met 
    370                 375                 380                 


Phe Lys Thr Glu Gly Pro Asp Ser Asp 
385                 390             


<210> 3
<211> 5718
<212> DNA
<213> Homo sapiens

<400> 3
ctcctgaggc tgccagcagc cagcagtgac tgcccgccct atctgggacc caggatcgct       60

ctgtgagcaa cttggagcca gagaggagat caacaaggag gaggagagag ccggcccctc      120

agccctgctg cccagcagca gcctgtgctc gccctgccca acgcagacag ccagacccag      180

ggcggcccct ctggcggctc tgctcctccc gaaggatgct tggggagtga ggcgaagctg      240

ggccgctcct ctcccctaca gcagccccct tcctccatcc ctctgttctc ctgagccttc      300

aggagcctgc accagtcctg cctgtccttc tactcagctg ttacccactc tgggaccagc      360

agtctttctg ataactggga gagggcagta aggaggactt cctggagggg gtgactgtcc      420

agagcctgga actgtgccca caccagaagc catcagcagc aaggacacca tgcggcttcc      480

gggtgcgatg ccagctctgg ccctcaaagg cgagctgctg ttgctgtctc tcctgttact      540

tctggaacca cagatctctc agggcctggt cgtcacaccc ccggggccag agcttgtcct      600

caatgtctcc agcaccttcg ttctgacctg ctcgggttca gctccggtgg tgtgggaacg      660

gatgtcccag gagcccccac aggaaatggc caaggcccag gatggcacct tctccagcgt      720

gctcacactg accaacctca ctgggctaga cacgggagaa tacttttgca cccacaatga      780

ctcccgtgga ctggagaccg atgagcggaa acggctctac atctttgtgc cagatcccac      840

cgtgggcttc ctccctaatg atgccgagga actattcatc tttctcacgg aaataactga      900

gatcaccatt ccatgccgag taacagaccc acagctggtg gtgacactgc acgagaagaa      960

aggggacgtt gcactgcctg tcccctatga tcaccaacgt ggcttttctg gtatctttga     1020

ggacagaagc tacatctgca aaaccaccat tggggacagg gaggtggatt ctgatgccta     1080

ctatgtctac agactccagg tgtcatccat caacgtctct gtgaacgcag tgcagactgt     1140

ggtccgccag ggtgagaaca tcaccctcat gtgcattgtg atcgggaatg aggtggtcaa     1200

cttcgagtgg acataccccc gcaaagaaag tgggcggctg gtggagccgg tgactgactt     1260

cctcttggat atgccttacc acatccgctc catcctgcac atccccagtg ccgagttaga     1320

agactcgggg acctacacct gcaatgtgac ggagagtgtg aatgaccatc aggatgaaaa     1380

ggccatcaac atcaccgtgg ttgagagcgg ctacgtgcgg ctcctgggag aggtgggcac     1440

actacaattt gctgagctgc atcggagccg gacactgcag gtagtgttcg aggcctaccc     1500

accgcccact gtcctgtggt tcaaagacaa ccgcaccctg ggcgactcca gcgctggcga     1560

aatcgccctg tccacgcgca acgtgtcgga gacccggtat gtgtcagagc tgacactggt     1620

tcgcgtgaag gtggcagagg ctggccacta caccatgcgg gccttccatg aggatgctga     1680

ggtccagctc tccttccagc tacagatcaa tgtccctgtc cgagtgctgg agctaagtga     1740

gagccaccct gacagtgggg aacagacagt ccgctgtcgt ggccggggca tgccccagcc     1800

gaacatcatc tggtctgcct gcagagacct caaaaggtgt ccacgtgagc tgccgcccac     1860

gctgctgggg aacagttccg aagaggagag ccagctggag actaacgtga cgtactggga     1920

ggaggagcag gagtttgagg tggtgagcac actgcgtctg cagcacgtgg atcggccact     1980

gtcggtgcgc tgcacgctgc gcaacgctgt gggccaggac acgcaggagg tcatcgtggt     2040

gccacactcc ttgcccttta aggtggtggt gatctcagcc atcctggccc tggtggtgct     2100

caccatcatc tcccttatca tcctcatcat gctttggcag aagaagccac gttacgagat     2160

ccgatggaag gtgattgagt ctgtgagctc tgacggccat gagtacatct acgtggaccc     2220

catgcagctg ccctatgact ccacgtggga gctgccgcgg gaccagcttg tgctgggacg     2280

caccctcggc tctggggcct ttgggcaggt ggtggaggcc acggctcatg gcctgagcca     2340

ttctcaggcc acgatgaaag tggccgtcaa gatgcttaaa tccacagccc gcagcagtga     2400

gaagcaagcc cttatgtcgg agctgaagat catgagtcac cttgggcccc acctgaacgt     2460

ggtcaacctg ttgggggcct gcaccaaagg aggacccatc tatatcatca ctgagtactg     2520

ccgctacgga gacctggtgg actacctgca ccgcaacaaa cacaccttcc tgcagcacca     2580

ctccgacaag cgccgcccgc ccagcgcgga gctctacagc aatgctctgc ccgttgggct     2640

ccccctgccc agccatgtgt ccttgaccgg ggagagcgac ggtggctaca tggacatgag     2700

caaggacgag tcggtggact atgtgcccat gctggacatg aaaggagacg tcaaatatgc     2760

agacatcgag tcctccaact acatggcccc ttacgataac tacgttccct ctgcccctga     2820

gaggacctgc cgagcaactt tgatcaacga gtctccagtg ctaagctaca tggacctcgt     2880

gggcttcagc taccaggtgg ccaatggcat ggagtttctg gcctccaaga actgcgtcca     2940

cagagacctg gcggctagga acgtgctcat ctgtgaaggc aagctggtca agatctgtga     3000

ctttggcctg gctcgagaca tcatgcggga ctcgaattac atctccaaag gcagcacctt     3060

tttgccttta aagtggatgg ctccggagag catcttcaac agcctctaca ccaccctgag     3120

cgacgtgtgg tccttcggga tcctgctctg ggagatcttc accttgggtg gcacccctta     3180

cccagagctg cccatgaacg agcagttcta caatgccatc aaacggggtt accgcatggc     3240

ccagcctgcc catgcctccg acgagatcta tgagatcatg cagaagtgct gggaagagaa     3300

gtttgagatt cggcccccct tctcccagct ggtgctgctt ctcgagagac tgttgggcga     3360

aggttacaaa aagaagtacc agcaggtgga tgaggagttt ctgaggagtg accacccagc     3420

catccttcgg tcccaggccc gcttgcctgg gttccatggc ctccgatctc ccctggacac     3480

cagctccgtc ctctatactg ccgtgcagcc caatgagggt gacaacgact atatcatccc     3540

cctgcctgac cccaaacccg aggttgctga cgagggccca ctggagggtt cccccagcct     3600

agccagctcc accctgaatg aagtcaacac ctcctcaacc atctcctgtg acagccccct     3660

ggagccccag gacgaaccag agccagagcc ccagcttgag ctccaggtgg agccggagcc     3720

agagctggaa cagttgccgg attcggggtg ccctgcgcct cgggcggaag cagaggatag     3780

cttcctgtag ggggctggcc cctaccctgc cctgcctgaa gctccccccc tgccagcacc     3840

cagcatctcc tggcctggcc tgaccgggct tcctgtcagc caggctgccc ttatcagctg     3900

tccccttctg gaagctttct gctcctgacg tgttgtgccc caaaccctgg ggctggctta     3960

ggaggcaaga aaactgcagg ggccgtgacc agccctctgc ctccagggag gccaactgac     4020

tctgagccag ggttccccca gggaactcag ttttcccata tgtaagatgg gaaagttagg     4080

cttgatgacc cagaatctag gattctctcc ctggctgaca ggtggggaga ccgaatccct     4140

ccctgggaag attcttggag ttactgaggt ggtaaattaa cttttttctg ttcagccagc     4200

tacccctcaa ggaatcatag ctctctcctc gcacttttat ccacccagga gctagggaag     4260

agaccctagc ctccctggct gctggctgag ctagggccta gccttgagca gtgttgcctc     4320

atccagaaga aagccagtct cctccctatg atgccagtcc ctgcgttccc tggcccgagc     4380

tggtctgggg ccattaggca gcctaattaa tgctggaggc tgagccaagt acaggacacc     4440

cccagcctgc agcccttgcc cagggcactt ggagcacacg cagccatagc aagtgcctgt     4500

gtccctgtcc ttcaggccca tcagtcctgg ggctttttct ttatcaccct cagtcttaat     4560

ccatccacca gagtctagaa ggccagacgg gccccgcatc tgtgatgaga atgtaaatgt     4620

gccagtgtgg agtggccacg tgtgtgtgcc agtatatggc cctggctctg cattggacct     4680

gctatgaggc tttggaggaa tccctcaccc tctctgggcc tcagtttccc cttcaaaaaa     4740

tgaataagtc ggacttatta actctgagtg ccttgccagc actaacattc tagagtattc     4800

caggtggttg cacatttgtc cagatgaagc aaggccatat accctaaact tccatcctgg     4860

gggtcagctg ggctcctggg agattccaga tcacacatca cactctgggg actcaggaac     4920

catgcccctt ccccaggccc ccagcaagtc tcaagaacac agctgcacag gccttgactt     4980

agagtgacag ccggtgtcct ggaaagcccc cagcagctgc cccagggaca tgggaagacc     5040

acgggacctc tttcactacc cacgatgacc tccgggggta tcctgggcaa aagggacaaa     5100

gagggcaaat gagatcacct cctgcagccc accactccag cacctgtgcc gaggtctgcg     5160

tcgaagacag aatggacagt gaggacagtt atgtcttgta aaagacaaga agcttcagat     5220

gggtacccca agaaggatgt gagaggtggg cgctttggag gtttgcccct cacccaccag     5280

ctgccccatc cctgaggcag cgctccatgg gggtatggtt ttgtcactgc ccagacctag     5340

cagtgacatc tcattgtccc cagcccagtg ggcattggag gtgccagggg agtcagggtt     5400

gtagccaaga cgcccccgca cggggagggt tgggaagggg gtgcaggaag ctcaacccct     5460

ctgggcacca accctgcatt gcaggttggc accttacttc cctgggatcc ccagagttgg     5520

tccaaggagg gagagtgggt tctcaatacg gtaccaaaga tataatcacc taggtttaca     5580

aatattttta ggactcacgt taactcacat ttatacagca gaaatgctat tttgtatgct     5640

gttaagtttt tctatctgtg tacttttttt taagggaaag attttaatat taaacctggt     5700

gcttctcact cacaaaaa                                                   5718


<210> 4
<211> 1106
<212> PRT
<213> Homo sapiens

<400> 4
Met Arg Leu Pro Gly Ala Met Pro Ala Leu Ala Leu Lys Gly Glu Leu 
1               5                   10                  15      


Leu Leu Leu Ser Leu Leu Leu Leu Leu Glu Pro Gln Ile Ser Gln Gly 
            20                  25                  30          


Leu Val Val Thr Pro Pro Gly Pro Glu Leu Val Leu Asn Val Ser Ser 
        35                  40                  45              


Thr Phe Val Leu Thr Cys Ser Gly Ser Ala Pro Val Val Trp Glu Arg 
    50                  55                  60                  


Met Ser Gln Glu Pro Pro Gln Glu Met Ala Lys Ala Gln Asp Gly Thr 
65                  70                  75                  80  


Phe Ser Ser Val Leu Thr Leu Thr Asn Leu Thr Gly Leu Asp Thr Gly 
                85                  90                  95      


Glu Tyr Phe Cys Thr His Asn Asp Ser Arg Gly Leu Glu Thr Asp Glu 
            100                 105                 110         


Arg Lys Arg Leu Tyr Ile Phe Val Pro Asp Pro Thr Val Gly Phe Leu 
        115                 120                 125             


Pro Asn Asp Ala Glu Glu Leu Phe Ile Phe Leu Thr Glu Ile Thr Glu 
    130                 135                 140                 


Ile Thr Ile Pro Cys Arg Val Thr Asp Pro Gln Leu Val Val Thr Leu 
145                 150                 155                 160 


His Glu Lys Lys Gly Asp Val Ala Leu Pro Val Pro Tyr Asp His Gln 
                165                 170                 175     


Arg Gly Phe Ser Gly Ile Phe Glu Asp Arg Ser Tyr Ile Cys Lys Thr 
            180                 185                 190         


Thr Ile Gly Asp Arg Glu Val Asp Ser Asp Ala Tyr Tyr Val Tyr Arg 
        195                 200                 205             


Leu Gln Val Ser Ser Ile Asn Val Ser Val Asn Ala Val Gln Thr Val 
    210                 215                 220                 


Val Arg Gln Gly Glu Asn Ile Thr Leu Met Cys Ile Val Ile Gly Asn 
225                 230                 235                 240 


Glu Val Val Asn Phe Glu Trp Thr Tyr Pro Arg Lys Glu Ser Gly Arg 
                245                 250                 255     


Leu Val Glu Pro Val Thr Asp Phe Leu Leu Asp Met Pro Tyr His Ile 
            260                 265                 270         


Arg Ser Ile Leu His Ile Pro Ser Ala Glu Leu Glu Asp Ser Gly Thr 
        275                 280                 285             


Tyr Thr Cys Asn Val Thr Glu Ser Val Asn Asp His Gln Asp Glu Lys 
    290                 295                 300                 


Ala Ile Asn Ile Thr Val Val Glu Ser Gly Tyr Val Arg Leu Leu Gly 
305                 310                 315                 320 


Glu Val Gly Thr Leu Gln Phe Ala Glu Leu His Arg Ser Arg Thr Leu 
                325                 330                 335     


Gln Val Val Phe Glu Ala Tyr Pro Pro Pro Thr Val Leu Trp Phe Lys 
            340                 345                 350         


Asp Asn Arg Thr Leu Gly Asp Ser Ser Ala Gly Glu Ile Ala Leu Ser 
        355                 360                 365             


Thr Arg Asn Val Ser Glu Thr Arg Tyr Val Ser Glu Leu Thr Leu Val 
    370                 375                 380                 


Arg Val Lys Val Ala Glu Ala Gly His Tyr Thr Met Arg Ala Phe His 
385                 390                 395                 400 


Glu Asp Ala Glu Val Gln Leu Ser Phe Gln Leu Gln Ile Asn Val Pro 
                405                 410                 415     


Val Arg Val Leu Glu Leu Ser Glu Ser His Pro Asp Ser Gly Glu Gln 
            420                 425                 430         


Thr Val Arg Cys Arg Gly Arg Gly Met Pro Gln Pro Asn Ile Ile Trp 
        435                 440                 445             


Ser Ala Cys Arg Asp Leu Lys Arg Cys Pro Arg Glu Leu Pro Pro Thr 
    450                 455                 460                 


Leu Leu Gly Asn Ser Ser Glu Glu Glu Ser Gln Leu Glu Thr Asn Val 
465                 470                 475                 480 


Thr Tyr Trp Glu Glu Glu Gln Glu Phe Glu Val Val Ser Thr Leu Arg 
                485                 490                 495     


Leu Gln His Val Asp Arg Pro Leu Ser Val Arg Cys Thr Leu Arg Asn 
            500                 505                 510         


Ala Val Gly Gln Asp Thr Gln Glu Val Ile Val Val Pro His Ser Leu 
        515                 520                 525             


Pro Phe Lys Val Val Val Ile Ser Ala Ile Leu Ala Leu Val Val Leu 
    530                 535                 540                 


Thr Ile Ile Ser Leu Ile Ile Leu Ile Met Leu Trp Gln Lys Lys Pro 
545                 550                 555                 560 


Arg Tyr Glu Ile Arg Trp Lys Val Ile Glu Ser Val Ser Ser Asp Gly 
                565                 570                 575     


His Glu Tyr Ile Tyr Val Asp Pro Met Gln Leu Pro Tyr Asp Ser Thr 
            580                 585                 590         


Trp Glu Leu Pro Arg Asp Gln Leu Val Leu Gly Arg Thr Leu Gly Ser 
        595                 600                 605             


Gly Ala Phe Gly Gln Val Val Glu Ala Thr Ala His Gly Leu Ser His 
    610                 615                 620                 


Ser Gln Ala Thr Met Lys Val Ala Val Lys Met Leu Lys Ser Thr Ala 
625                 630                 635                 640 


Arg Ser Ser Glu Lys Gln Ala Leu Met Ser Glu Leu Lys Ile Met Ser 
                645                 650                 655     


His Leu Gly Pro His Leu Asn Val Val Asn Leu Leu Gly Ala Cys Thr 
            660                 665                 670         


Lys Gly Gly Pro Ile Tyr Ile Ile Thr Glu Tyr Cys Arg Tyr Gly Asp 
        675                 680                 685             


Leu Val Asp Tyr Leu His Arg Asn Lys His Thr Phe Leu Gln His His 
    690                 695                 700                 


Ser Asp Lys Arg Arg Pro Pro Ser Ala Glu Leu Tyr Ser Asn Ala Leu 
705                 710                 715                 720 


Pro Val Gly Leu Pro Leu Pro Ser His Val Ser Leu Thr Gly Glu Ser 
                725                 730                 735     


Asp Gly Gly Tyr Met Asp Met Ser Lys Asp Glu Ser Val Asp Tyr Val 
            740                 745                 750         


Pro Met Leu Asp Met Lys Gly Asp Val Lys Tyr Ala Asp Ile Glu Ser 
        755                 760                 765             


Ser Asn Tyr Met Ala Pro Tyr Asp Asn Tyr Val Pro Ser Ala Pro Glu 
    770                 775                 780                 


Arg Thr Cys Arg Ala Thr Leu Ile Asn Glu Ser Pro Val Leu Ser Tyr 
785                 790                 795                 800 


Met Asp Leu Val Gly Phe Ser Tyr Gln Val Ala Asn Gly Met Glu Phe 
                805                 810                 815     


Leu Ala Ser Lys Asn Cys Val His Arg Asp Leu Ala Ala Arg Asn Val 
            820                 825                 830         


Leu Ile Cys Glu Gly Lys Leu Val Lys Ile Cys Asp Phe Gly Leu Ala 
        835                 840                 845             


Arg Asp Ile Met Arg Asp Ser Asn Tyr Ile Ser Lys Gly Ser Thr Phe 
    850                 855                 860                 


Leu Pro Leu Lys Trp Met Ala Pro Glu Ser Ile Phe Asn Ser Leu Tyr 
865                 870                 875                 880 


Thr Thr Leu Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile 
                885                 890                 895     


Phe Thr Leu Gly Gly Thr Pro Tyr Pro Glu Leu Pro Met Asn Glu Gln 
            900                 905                 910         


Phe Tyr Asn Ala Ile Lys Arg Gly Tyr Arg Met Ala Gln Pro Ala His 
        915                 920                 925             


Ala Ser Asp Glu Ile Tyr Glu Ile Met Gln Lys Cys Trp Glu Glu Lys 
    930                 935                 940                 


Phe Glu Ile Arg Pro Pro Phe Ser Gln Leu Val Leu Leu Leu Glu Arg 
945                 950                 955                 960 


Leu Leu Gly Glu Gly Tyr Lys Lys Lys Tyr Gln Gln Val Asp Glu Glu 
                965                 970                 975     


Phe Leu Arg Ser Asp His Pro Ala Ile Leu Arg Ser Gln Ala Arg Leu 
            980                 985                 990         


Pro Gly Phe His Gly Leu Arg Ser  Pro Leu Asp Thr Ser  Ser Val Leu 
        995                 1000                 1005             


Tyr Thr  Ala Val Gln Pro Asn  Glu Gly Asp Asn Asp  Tyr Ile Ile 
    1010                 1015                 1020             


Pro Leu  Pro Asp Pro Lys Pro  Glu Val Ala Asp Glu  Gly Pro Leu 
    1025                 1030                 1035             


Glu Gly  Ser Pro Ser Leu Ala  Ser Ser Thr Leu Asn  Glu Val Asn 
    1040                 1045                 1050             


Thr Ser  Ser Thr Ile Ser Cys  Asp Ser Pro Leu Glu  Pro Gln Asp 
    1055                 1060                 1065             


Glu Pro  Glu Pro Glu Pro Gln  Leu Glu Leu Gln Val  Glu Pro Glu 
    1070                 1075                 1080             


Pro Glu  Leu Glu Gln Leu Pro  Asp Ser Gly Cys Pro  Ala Pro Arg 
    1085                 1090                 1095             


Ala Glu  Ala Glu Asp Ser Phe  Leu 
    1100                 1105     


<210> 5
<211> 97
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 5
tgctgttgac agtgagcgcc cactacaagt acatgtgtaa tagtgaagcc acagatgtat       60

tacacatgta cttgtagtgg atgcctactg cctcgga                                97


<210> 6
<211> 97
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 6
tgctgttgac agtgagcgcc cgggtggaag gaaatttgta tagtgaagcc acagatgtat       60

acaaatttcc ttccacccgg atgcctactg cctcgga                                97


<210> 7
<211> 97
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 7
tgctgttgac agtgagcgac cctgtcatct tttgtccctt tagtgaagcc acagatgtaa       60

agggacaaaa gatgacaggg gtgcctactg cctcgga                                97


<210> 8
<211> 97
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 8
tgctgttgac agtgagcgcc tggaagactc cagtggtaat tagtgaagcc acagatgtaa       60

ttaccactgg agtcttccag ttgcctactg cctcgga                                97


<210> 9
<211> 97
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 9
tgctgttgac agtgagcgcg gaggatttca tctcttgtat tagtgaagcc acagatgtaa       60

tacaagagat gaaatcctcc atgcctactg cctcgga                                97


<210> 10
<211> 97
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 10
tgctgttgac agtgagcgat gggccagagt ttgttctcaa tagtgaagcc acagatgtat       60

tgagaacaaa ctctggccca gtgcctactg cctcgga                                97


<210> 11
<211> 97
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 11
tgctgttgac agtgagcgcc acaatggtac caaagataga tagtgaagcc acagatgtat       60

ctatctttgg taccattgtg atgcctactg cctcgga                                97


<210> 12
<211> 97
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 12
tgctgttgac agtgagcgac agcactaaca ttctagagta tagtgaagcc acagatgtat       60

actctagaat gttagtgctg gtgcctactg cctcgga                                97


<210> 13
<211> 97
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 13
tgctgttgac agtgagcgac agttctacaa tgccatcaaa tagtgaagcc acagatgtat       60

ttgatggcat tgtagaactg ctgcctactg cctcgga                                97


<210> 14
<211> 97
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 14
tgctgttgac agtgagcgac ccactcttga agaagttgta tagtgaagcc acagatgtat       60

acaacttctt caagagtggg gtgcctactg cctcgga                                97


<210> 15
<211> 97
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 15
tgctgttgac agtgagcgac agctttgtgc atccaattaa tagtgaagcc acagatgtat       60

taattggatg cacaaagctg gtgcctactg cctcgga                                97


<210> 16
<211> 97
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 16
tgctgttgac agtgagcgac tagggatttc tgcagactaa tagtgaagcc acagatgtat       60

tagtctgcag aaatccctag ctgcctactg cctcgga                                97


<210> 17
<211> 97
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 17
tgctgttgac agtgagcgcc aggagaagcg gaagacaata tagtgaagcc acagatgtat       60

attgtcttcc gcttctcctg atgcctactg cctcgga                                97


<210> 18
<211> 97
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 18
tgctgttgac agtgagcgca ggaattataa tgcttatcta tagtgaagcc acagatgtat       60

agataagcat tataattcct atgcctactg cctcgga                                97


<210> 19
<211> 97
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 19
tgctgttgac agtgagcgcc cgcctgaagt ctctgattaa tagtgaagcc acagatgtat       60

taatcagaga cttcaggcgg ttgcctactg cctcgga                                97


<210> 20
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 20
ttccaggagt gataccagct t                                                 21


<210> 21
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 21
agggggcgtg atgactagg                                                    19


<210> 22
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 22
cgccagggcg agagcatcac                                                   20


<210> 23
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 23
cgcccactct tcatgcgggg                                                   20


<210> 24
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 24
tccatgctag actcagaagt ca                                                22


<210> 25
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 25
tcccggtgga cacaattttt c                                                 21


<210> 26
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 26
atgagagtga gatcgaaggc a                                                 21


<210> 27
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 27
cggcaaggta tgatggcaga g                                                 21


<210> 28
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 28
agacacggga gaatactttt gc                                                22


<210> 29
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 29
agttcctcgg catcattagg g                                                 21


<210> 30
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 30
gcaaaaccac cattggggac                                                   20


<210> 31
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 31
gggtgatgtt ctcaccctgg                                                   20


<210> 32
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 32
ccacctgcag aaccttacca                                                   20


<210> 33
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 33
tcatggctct gcttcaggtc                                                   20


<210> 34
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 34
aaaatggagc tgccagcaaa c                                                 21


<210> 35
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 35
tggcgtctct tcttcacgtt g                                                 21


