                         SEQUENCE LISTING

<110>  HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.
       RUTENBERG, Abraham
       UZANA, Ronny
       LOTEM, Michal
       MACHLENKIN, Arthur
       EISENBERG, Galit
       PERETZ-YABLONSKY, Tamar
       FRANKENBURG, Shoshana
       ENGELSTEIN, Roni
 
<120>  IMPROVED CELL COMPOSITIONS AND METHODS FOR CANCER THERAPY

<130>  HDST/038 PCT

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  332
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Leu Trp Leu Phe Gln Ser Leu Leu Phe Val Phe Cys Phe Gly Pro 
1               5                   10                  15      


Gly Asn Val Val Ser Gln Ser Ser Leu Thr Pro Leu Met Val Asn Gly 
            20                  25                  30          


Ile Leu Gly Glu Ser Val Thr Leu Pro Leu Glu Phe Pro Ala Gly Glu 
        35                  40                  45              


Lys Val Asn Phe Ile Thr Trp Leu Phe Asn Glu Thr Ser Leu Ala Phe 
    50                  55                  60                  


Ile Val Pro His Glu Thr Lys Ser Pro Glu Ile His Val Thr Asn Pro 
65                  70                  75                  80  


Lys Gln Gly Lys Arg Leu Asn Phe Thr Gln Ser Tyr Ser Leu Gln Leu 
                85                  90                  95      


Ser Asn Leu Lys Met Glu Asp Thr Gly Ser Tyr Arg Ala Gln Ile Ser 
            100                 105                 110         


Thr Lys Thr Ser Ala Lys Leu Ser Ser Tyr Thr Leu Arg Ile Leu Arg 
        115                 120                 125             


Gln Leu Arg Asn Ile Gln Val Thr Asn His Ser Gln Leu Phe Gln Asn 
    130                 135                 140                 


Met Thr Cys Glu Leu His Leu Thr Cys Ser Val Glu Asp Ala Asp Asp 
145                 150                 155                 160 


Asn Val Ser Phe Arg Trp Glu Ala Leu Gly Asn Thr Leu Ser Ser Gln 
                165                 170                 175     


Pro Asn Leu Thr Val Ser Trp Asp Pro Arg Ile Ser Ser Glu Gln Asp 
            180                 185                 190         


Tyr Thr Cys Ile Ala Glu Asn Ala Val Ser Asn Leu Ser Phe Ser Val 
        195                 200                 205             


Ser Ala Gln Lys Leu Cys Glu Asp Val Lys Ile Gln Tyr Thr Asp Thr 
    210                 215                 220                 


Lys Met Ile Leu Phe Met Val Ser Gly Ile Cys Ile Val Phe Gly Phe 
225                 230                 235                 240 


Ile Ile Leu Leu Leu Leu Val Leu Arg Lys Arg Arg Asp Ser Leu Ser 
                245                 250                 255     


Leu Ser Thr Gln Arg Thr Gln Gly Pro Ala Glu Ser Ala Arg Asn Leu 
            260                 265                 270         


Glu Tyr Val Ser Val Ser Pro Thr Asn Asn Thr Val Tyr Ala Ser Val 
        275                 280                 285             


Thr His Ser Asn Arg Glu Thr Glu Ile Trp Thr Pro Arg Glu Asn Asp 
    290                 295                 300                 


Thr Ile Thr Ile Tyr Ser Thr Ile Asn His Ser Lys Glu Ser Lys Pro 
305                 310                 315                 320 


Thr Phe Ser Arg Ala Thr Ala Leu Asp Asn Val Val 
                325                 330         


<210>  2
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  2

Gln Ser Ser Leu Thr Pro Leu Met Val Asn Gly Ile Leu Gly Glu Ser 
1               5                   10                  15      


Val Thr Leu Pro Leu Glu Phe Pro Ala Gly Glu Lys Val Asn Phe Ile 
            20                  25                  30          


Thr Trp Leu Phe Asn Glu Thr Ser Leu Ala Phe Ile Val Pro His Glu 
        35                  40                  45              


Thr Lys Ser Pro Glu Ile His Val Thr Asn Pro Lys Gln Gly Lys Arg 
    50                  55                  60                  


Leu Asn Phe Thr Gln Ser Tyr Ser Leu Gln Leu Ser Asn Leu Lys Met 
65                  70                  75                  80  


Glu Asp Thr Gly Ser Tyr Arg Ala Gln Ile Ser Thr Lys Thr Ser Ala 
                85                  90                  95      


Lys Leu Ser Ser Tyr Thr Leu Arg Ile Leu Arg Gln Leu Arg Asn Ile 
            100                 105                 110         


Gln Val Thr Asn His Ser Gln Leu Phe Gln Asn Met Thr Cys Glu Leu 
        115                 120                 125             


His Leu Thr Cys Ser Val Glu Asp Ala Asp Asp Asn Val Ser Phe Arg 
    130                 135                 140                 


Trp Glu Ala Leu Gly Asn Thr Leu Ser Ser Gln Pro Asn Leu Thr Val 
145                 150                 155                 160 


Ser Trp Asp Pro Arg Ile Ser Ser Glu Gln Asp Tyr Thr Cys Ile Ala 
                165                 170                 175     


Glu Asn Ala Val Ser Asn Leu Ser Phe Ser Val Ser Ala Gln Lys Leu 
            180                 185                 190         


Cys Glu Asp Val Lys Ile Gln Tyr Thr Asp Thr Lys Met 
        195                 200                 205 


<210>  3
<211>  206
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  3

Leu Met Val Asn Gly Ile Leu Gly Glu Ser Val Thr Leu Pro Leu Glu 
1               5                   10                  15      


Phe Pro Ala Gly Glu Lys Val Asn Phe Ile Thr Trp Leu Phe Asn Glu 
            20                  25                  30          


Thr Ser Leu Ala Phe Ile Val Pro His Glu Thr Lys Ser Pro Glu Ile 
        35                  40                  45              


His Val Thr Asn Pro Lys Gln Gly Lys Arg Leu Asn Phe Thr Gln Ser 
    50                  55                  60                  


Tyr Ser Leu Gln Leu Ser Asn Leu Lys Met Glu Asp Thr Gly Ser Tyr 
65                  70                  75                  80  


Arg Ala Gln Ile Ser Thr Lys Thr Ser Ala Lys Leu Ser Ser Tyr Thr 
                85                  90                  95      


Leu Arg Ile Leu Arg Gln Leu Arg Asn Ile Gln Val Thr Asn His Ser 
            100                 105                 110         


Gln Leu Phe Gln Asn Met Thr Cys Glu Leu His Leu Thr Cys Ser Val 
        115                 120                 125             


Glu Asp Ala Asp Asp Asn Val Ser Phe Arg Trp Glu Ala Leu Gly Asn 
    130                 135                 140                 


Thr Leu Ser Ser Gln Pro Asn Leu Thr Val Ser Trp Asp Pro Arg Ile 
145                 150                 155                 160 


Ser Ser Glu Gln Asp Tyr Thr Cys Ile Ala Glu Asn Ala Val Ser Asn 
                165                 170                 175     


Leu Ser Phe Ser Val Ser Ala Gln Lys Leu Cys Glu Asp Val Lys Ile 
            180                 185                 190         


Gln Tyr Thr Asp Thr Lys Val Asp His His His His His His 
        195                 200                 205     


<210>  4
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro 
            20                  25                  30          


Ala Gly Thr Phe Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys 
        35                  40                  45              


Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile 
    50                  55                  60                  


Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser 
65                  70                  75                  80  


Thr Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly Phe His Cys Leu Gly 
                85                  90                  95      


Ala Gly Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu 
            100                 105                 110         


Thr Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln 
        115                 120                 125             


Lys Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys 
    130                 135                 140                 


Ser Val Leu Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro 
145                 150                 155                 160 


Ser Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala 
                165                 170                 175     


Pro Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe Leu 
            180                 185                 190         


Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu 
        195                 200                 205             


Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    210                 215                 220                 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
225                 230                 235                 240 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 255 


<210>  5
<211>  185
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu 
1               5                   10                  15      


Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu 
            20                  25                  30          


Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly 
        35                  40                  45              


Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu 
    50                  55                  60                  


Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu 
65                  70                  75                  80  


Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu 
                85                  90                  95      


His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu 
            100                 105                 110         


Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe 
        115                 120                 125             


Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly 
    130                 135                 140                 


Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr 
145                 150                 155                 160 


Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro 
                165                 170                 175     


Ala Gly Leu Pro Ser Pro Arg Ser Glu 
            180                 185 


