                         SEQUENCE LISTING

<110>  Valneva Austria GmbH
 
<120>  MUTANT FRAGMENTS OF OspA AND METHODS

<130>  V69542PC

<160>  63    

<170>  PatentIn version 3.5

<210>  1
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S3hybD1

<400>  1

Phe Asn Glu Lys Gly Glu Val Ser Glu Lys Ile Leu Thr Arg Ser Asn 
1               5                   10                  15      


Gly Thr Thr Leu Glu Tyr Ser Gln Met Thr Asp Ala Glu Asn Ala Thr 
            20                  25                  30          


Lys Ala Val Glu Thr Leu Lys Asn Gly Ile Lys Leu Pro Gly Asn Leu 
        35                  40                  45              


Val Gly Gly Lys Thr Lys Leu Thr Val Thr Cys Gly Thr Val Thr Leu 
    50                  55                  60                  


Ser Lys Asn Ile Ser Lys Ser Gly Glu Ile Thr Val Ala Leu Asn Asp 
65                  70                  75                  80  


Thr Glu Thr Thr Pro Ala Asp Lys Lys Thr Gly Glu Trp Lys Ser Asp 
                85                  90                  95      


Thr Ser Thr Leu Thr Ile Ser Lys Asn Ser Gln Lys Thr Lys Gln Leu 
            100                 105                 110         


Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln Asn Tyr Asn Arg Ala 
        115                 120                 125             


Gly Asn Ala Leu Glu Gly Ser Pro Ala Glu Ile Lys Asp Leu Ala Glu 
    130                 135                 140                 


Leu Cys Ala Ala Leu Lys 
145                 150 


<210>  2
<211>  52
<212>  PRT
<213>  Borrelia valaisiana

<400>  2

Phe Asn Glu Lys Gly Glu Val Ser Glu Lys Ile Leu Thr Arg Ser Asn 
1               5                   10                  15      


Gly Thr Thr Leu Glu Tyr Ser Gln Met Thr Asp Ala Glu Asn Ala Thr 
            20                  25                  30          


Lys Ala Val Glu Thr Leu Lys Asn Gly Ile Lys Leu Pro Gly Asn Leu 
        35                  40                  45              


Val Gly Gly Lys 
    50          


<210>  3
<211>  98
<212>  PRT
<213>  Borrelia garinii

<400>  3

Thr Lys Leu Thr Val Thr Cys Gly Thr Val Thr Leu Ser Lys Asn Ile 
1               5                   10                  15      


Ser Lys Ser Gly Glu Ile Thr Val Ala Leu Asn Asp Thr Glu Thr Thr 
            20                  25                  30          


Pro Ala Asp Lys Lys Thr Gly Glu Trp Lys Ser Asp Thr Ser Thr Leu 
        35                  40                  45              


Thr Ile Ser Lys Asn Ser Gln Lys Thr Lys Gln Leu Val Phe Thr Lys 
    50                  55                  60                  


Glu Asn Thr Ile Thr Val Gln Asn Tyr Asn Arg Ala Gly Asn Ala Leu 
65                  70                  75                  80  


Glu Gly Ser Pro Ala Glu Ile Lys Asp Leu Ala Glu Leu Cys Ala Ala 
                85                  90                  95      


Leu Lys 
        


<210>  4
<211>  274
<212>  PRT
<213>  Borrelia valaisiana

<400>  4

Met Lys Lys Tyr Leu Leu Gly Ile Gly Leu Ile Leu Ala Leu Ile Ala 
1               5                   10                  15      


Cys Lys Gln Asn Val Ser Ser Leu Asp Glu Lys Asn Ser Ala Ser Val 
            20                  25                  30          


Asp Leu Pro Gly Glu Met Lys Val Leu Val Ser Lys Glu Lys Asp Lys 
        35                  40                  45              


Asp Gly Lys Tyr Ser Leu Val Ala Thr Val Asp Lys Val Glu Leu Lys 
    50                  55                  60                  


Gly Thr Ser Asp Lys Asn Asn Gly Ser Gly Thr Leu Glu Gly Val Lys 
65                  70                  75                  80  


Asp Asp Lys Ser Lys Val Lys Leu Thr Ile Ser Asp Asp Leu Gly Glu 
                85                  90                  95      


Thr Lys Leu Glu Thr Phe Lys Glu Asp Gly Thr Leu Val Ser Arg Lys 
            100                 105                 110         


Val Asn Phe Lys Asp Lys Ser Phe Thr Glu Glu Lys Phe Asn Glu Lys 
        115                 120                 125             


Gly Glu Val Ser Glu Lys Ile Leu Thr Arg Ser Asn Gly Thr Thr Leu 
    130                 135                 140                 


Glu Tyr Ser Gln Met Thr Asp Ala Glu Asn Ala Thr Lys Ala Val Glu 
145                 150                 155                 160 


Thr Leu Lys Asn Gly Ile Lys Leu Pro Gly Asn Leu Val Gly Gly Lys 
                165                 170                 175     


Thr Thr Leu Lys Ile Thr Glu Gly Thr Val Thr Leu Ser Lys His Ile 
            180                 185                 190         


Ala Lys Ser Gly Glu Val Thr Val Glu Ile Asn Asp Thr Ser Ser Thr 
        195                 200                 205             


Pro Asn Thr Lys Lys Thr Gly Lys Trp Asp Ala Arg Asn Ser Thr Leu 
    210                 215                 220                 


Thr Ile Ile Val Asp Ser Lys Asn Lys Thr Lys Leu Val Phe Thr Lys 
225                 230                 235                 240 


Gln Asp Thr Ile Thr Val Gln Ser Tyr Asn Pro Ala Gly Asn Lys Leu 
                245                 250                 255     


Glu Gly Thr Ala Val Glu Ile Lys Thr Leu Gln Glu Leu Lys Asn Ala 
            260                 265                 270         


Leu Lys 
        


<210>  5
<211>  273
<212>  PRT
<213>  Borrelia burgdorferi

<400>  5

Met Lys Lys Tyr Leu Leu Gly Ile Gly Leu Ile Leu Ala Leu Ile Ala 
1               5                   10                  15      


Cys Lys Gln Asn Val Ser Ser Leu Asp Glu Lys Asn Ser Val Ser Val 
            20                  25                  30          


Asp Leu Pro Gly Glu Met Lys Val Leu Val Ser Lys Glu Lys Asn Lys 
        35                  40                  45              


Asp Gly Lys Tyr Asp Leu Ile Ala Thr Val Asp Lys Leu Glu Leu Lys 
    50                  55                  60                  


Gly Thr Ser Asp Lys Asn Asn Gly Ser Gly Val Leu Glu Gly Val Lys 
65                  70                  75                  80  


Ala Asp Lys Ser Lys Val Lys Leu Thr Ile Ser Asp Asp Leu Gly Gln 
                85                  90                  95      


Thr Thr Leu Glu Val Phe Lys Glu Asp Gly Lys Thr Leu Val Ser Lys 
            100                 105                 110         


Lys Val Thr Ser Lys Asp Lys Ser Ser Thr Glu Glu Lys Phe Asn Glu 
        115                 120                 125             


Lys Gly Glu Val Ser Glu Lys Ile Ile Thr Arg Ala Asp Gly Thr Arg 
    130                 135                 140                 


Leu Glu Tyr Thr Gly Ile Lys Ser Asp Gly Ser Gly Lys Ala Lys Glu 
145                 150                 155                 160 


Val Leu Lys Gly Tyr Val Leu Glu Gly Thr Leu Thr Ala Glu Lys Thr 
                165                 170                 175     


Thr Leu Val Val Lys Glu Gly Thr Val Thr Leu Ser Lys Asn Ile Ser 
            180                 185                 190         


Lys Ser Gly Glu Val Ser Val Glu Leu Asn Asp Thr Asp Ser Ser Ala 
        195                 200                 205             


Ala Thr Lys Lys Thr Ala Ala Trp Asn Ser Gly Thr Ser Thr Leu Thr 
    210                 215                 220                 


Ile Thr Val Asn Ser Lys Lys Thr Lys Asp Leu Val Phe Thr Lys Glu 
225                 230                 235                 240 


Asn Thr Ile Thr Val Gln Gln Tyr Asp Ser Asn Gly Thr Lys Leu Glu 
                245                 250                 255     


Gly Ser Ala Val Glu Ile Thr Lys Leu Asp Glu Ile Lys Asn Ala Leu 
            260                 265                 270         


Lys 
    


<210>  6
<211>  273
<212>  PRT
<213>  Borrelia afzelii

<400>  6

Met Lys Lys Tyr Leu Leu Gly Ile Gly Leu Ile Leu Ala Leu Ile Ala 
1               5                   10                  15      


Cys Lys Gln Asn Val Ser Ser Leu Asp Glu Lys Asn Ser Ala Ser Val 
            20                  25                  30          


Asp Leu Pro Gly Glu Met Lys Val Leu Val Ser Lys Glu Lys Asp Lys 
        35                  40                  45              


Asp Gly Lys Tyr Ser Leu Lys Ala Thr Val Asp Lys Ile Glu Leu Lys 
    50                  55                  60                  


Gly Thr Ser Asp Lys Asp Asn Gly Ser Gly Val Leu Glu Gly Thr Lys 
65                  70                  75                  80  


Asp Asp Lys Ser Lys Ala Lys Leu Thr Ile Ala Asp Asp Leu Ser Lys 
                85                  90                  95      


Thr Thr Phe Glu Leu Phe Lys Glu Asp Gly Lys Thr Leu Val Ser Arg 
            100                 105                 110         


Lys Val Ser Ser Lys Asp Lys Thr Ser Thr Asp Glu Met Phe Asn Glu 
        115                 120                 125             


Lys Gly Glu Leu Ser Ala Lys Thr Met Thr Arg Glu Asn Gly Thr Lys 
    130                 135                 140                 


Leu Glu Tyr Thr Glu Met Lys Ser Asp Gly Thr Gly Lys Ala Lys Glu 
145                 150                 155                 160 


Val Leu Lys Asn Phe Thr Leu Glu Gly Lys Val Ala Asn Asp Lys Val 
                165                 170                 175     


Thr Leu Glu Val Lys Glu Gly Thr Val Thr Leu Ser Lys Glu Ile Ala 
            180                 185                 190         


Lys Ser Gly Glu Val Thr Val Ala Leu Asn Asp Thr Asn Thr Thr Gln 
        195                 200                 205             


Ala Thr Lys Lys Thr Gly Ala Trp Asp Ser Lys Thr Ser Thr Leu Thr 
    210                 215                 220                 


Ile Ser Val Asn Ser Lys Lys Thr Thr Gln Leu Val Phe Thr Lys Gln 
225                 230                 235                 240 


Asp Thr Ile Thr Val Gln Lys Tyr Asp Ser Ala Gly Thr Asn Leu Glu 
                245                 250                 255     


Gly Thr Ala Val Glu Ile Lys Thr Leu Asp Glu Leu Lys Asn Ala Leu 
            260                 265                 270         


Lys 
    


<210>  7
<211>  274
<212>  PRT
<213>  Borrelia garinii

<400>  7

Met Lys Lys Tyr Leu Leu Gly Ile Gly Leu Ile Leu Ala Leu Ile Ala 
1               5                   10                  15      


Cys Lys Gln Asn Val Ser Ser Leu Asp Glu Lys Asn Ser Val Ser Val 
            20                  25                  30          


Asp Leu Pro Gly Gly Met Lys Val Leu Val Ser Lys Glu Lys Asp Lys 
        35                  40                  45              


Asp Gly Lys Tyr Ser Leu Met Ala Thr Val Glu Lys Leu Glu Leu Lys 
    50                  55                  60                  


Gly Thr Ser Asp Lys Ser Asn Gly Ser Gly Val Leu Glu Gly Glu Lys 
65                  70                  75                  80  


Ala Asp Lys Ser Lys Ala Lys Leu Thr Ile Ser Gln Asp Leu Asn Gln 
                85                  90                  95      


Thr Thr Phe Glu Ile Phe Lys Glu Asp Gly Lys Thr Leu Val Ser Arg 
            100                 105                 110         


Lys Val Asn Ser Lys Asp Lys Ser Ser Thr Glu Glu Lys Phe Asn Asp 
        115                 120                 125             


Lys Gly Lys Leu Ser Glu Lys Val Val Thr Arg Ala Asn Gly Thr Arg 
    130                 135                 140                 


Leu Glu Tyr Thr Glu Ile Lys Asn Asp Gly Ser Gly Lys Ala Lys Glu 
145                 150                 155                 160 


Val Leu Lys Gly Phe Ala Leu Glu Gly Thr Leu Thr Asp Gly Gly Glu 
                165                 170                 175     


Thr Lys Leu Thr Val Thr Glu Gly Thr Val Thr Leu Ser Lys Asn Ile 
            180                 185                 190         


Ser Lys Ser Gly Glu Ile Thr Val Ala Leu Asn Asp Thr Glu Thr Thr 
        195                 200                 205             


Pro Ala Asp Lys Lys Thr Gly Glu Trp Lys Ser Asp Thr Ser Thr Leu 
    210                 215                 220                 


Thr Ile Ser Lys Asn Ser Gln Lys Pro Lys Gln Leu Val Phe Thr Lys 
225                 230                 235                 240 


Glu Asn Thr Ile Thr Val Gln Asn Tyr Asn Arg Ala Gly Asn Ala Leu 
                245                 250                 255     


Glu Gly Ser Pro Ala Glu Ile Lys Asp Leu Ala Glu Leu Lys Ala Ala 
            260                 265                 270         


Leu Lys 
        


<210>  8
<211>  274
<212>  PRT
<213>  Borrelia garinii

<400>  8

Met Lys Lys Tyr Leu Leu Gly Ile Gly Leu Ile Leu Ala Leu Ile Ala 
1               5                   10                  15      


Cys Lys Gln Asn Val Ser Ser Leu Asp Glu Lys Asn Ser Val Ser Val 
            20                  25                  30          


Asp Leu Pro Gly Gly Met Lys Val Leu Val Ser Lys Glu Lys Asp Lys 
        35                  40                  45              


Asp Gly Lys Tyr Ser Leu Met Ala Thr Val Glu Lys Leu Glu Leu Lys 
    50                  55                  60                  


Gly Thr Ser Asp Lys Ser Asn Gly Ser Gly Val Leu Glu Gly Glu Lys 
65                  70                  75                  80  


Ala Asp Lys Ser Lys Ala Lys Leu Thr Ile Ser Gln Asp Leu Asn Gln 
                85                  90                  95      


Thr Thr Phe Glu Ile Phe Lys Glu Asp Gly Lys Thr Leu Val Ser Arg 
            100                 105                 110         


Lys Val Asn Ser Lys Asp Lys Ser Ser Thr Glu Glu Lys Phe Asn Asp 
        115                 120                 125             


Lys Gly Lys Leu Ser Glu Lys Val Val Thr Arg Ala Asn Gly Thr Arg 
    130                 135                 140                 


Leu Glu Tyr Thr Glu Ile Lys Asn Asp Gly Ser Gly Lys Ala Lys Glu 
145                 150                 155                 160 


Val Leu Lys Gly Phe Ala Leu Glu Gly Thr Leu Thr Asp Gly Gly Glu 
                165                 170                 175     


Thr Lys Leu Thr Val Thr Glu Gly Thr Val Thr Leu Ser Lys Asn Ile 
            180                 185                 190         


Ser Lys Ser Gly Glu Ile Thr Val Ala Leu Asn Asp Thr Glu Thr Thr 
        195                 200                 205             


Pro Ala Asp Lys Lys Thr Gly Glu Trp Lys Ser Asp Thr Ser Thr Leu 
    210                 215                 220                 


Thr Ile Ser Lys Asn Ser Gln Lys Thr Lys Gln Leu Val Phe Thr Lys 
225                 230                 235                 240 


Glu Asn Thr Ile Thr Val Gln Asn Tyr Asn Arg Ala Gly Asn Ala Leu 
                245                 250                 255     


Glu Gly Ser Pro Ala Glu Ile Lys Asp Leu Ala Glu Leu Lys Ala Ala 
            260                 265                 270         


Leu Lys 
        


<210>  9
<211>  273
<212>  PRT
<213>  Borrelia bavariensis

<400>  9

Met Lys Lys Tyr Leu Leu Gly Ile Gly Leu Ile Leu Ala Leu Ile Ala 
1               5                   10                  15      


Cys Lys Gln Asn Val Ser Ser Leu Asp Glu Lys Asn Ser Val Ser Val 
            20                  25                  30          


Asp Leu Pro Gly Glu Met Lys Val Leu Val Ser Lys Glu Lys Asp Lys 
        35                  40                  45              


Asp Gly Lys Tyr Ser Leu Met Ala Thr Val Asp Lys Leu Glu Leu Lys 
    50                  55                  60                  


Gly Thr Ser Asp Lys Ser Asn Gly Ser Gly Thr Leu Glu Gly Glu Lys 
65                  70                  75                  80  


Ser Asp Lys Ser Lys Ala Lys Leu Thr Ile Ser Glu Asp Leu Ser Lys 
                85                  90                  95      


Thr Thr Phe Glu Ile Phe Lys Glu Asp Gly Lys Thr Leu Val Ser Lys 
            100                 105                 110         


Lys Val Asn Ser Lys Asp Lys Ser Ser Ile Glu Glu Lys Phe Asn Ala 
        115                 120                 125             


Lys Gly Glu Leu Ser Glu Lys Thr Ile Leu Arg Ala Asn Gly Thr Arg 
    130                 135                 140                 


Leu Glu Tyr Thr Glu Ile Lys Ser Asp Gly Thr Gly Lys Ala Lys Glu 
145                 150                 155                 160 


Val Leu Lys Asp Phe Ala Leu Glu Gly Thr Leu Ala Ala Asp Lys Thr 
                165                 170                 175     


Thr Leu Lys Val Thr Glu Gly Thr Val Val Leu Ser Lys His Ile Pro 
            180                 185                 190         


Asn Ser Gly Glu Ile Thr Val Glu Leu Asn Asp Ser Asn Ser Thr Gln 
        195                 200                 205             


Ala Thr Lys Lys Thr Gly Lys Trp Asp Ser Asn Thr Ser Thr Leu Thr 
    210                 215                 220                 


Ile Ser Val Asn Ser Lys Lys Thr Lys Asn Ile Val Phe Thr Lys Glu 
225                 230                 235                 240 


Asp Thr Ile Thr Val Gln Lys Tyr Asp Ser Ala Gly Thr Asn Leu Glu 
                245                 250                 255     


Gly Asn Ala Val Glu Ile Lys Thr Leu Asp Glu Leu Lys Asn Ala Leu 
            260                 265                 270         


Lys 
    


<210>  10
<211>  273
<212>  PRT
<213>  Borrelia garinii

<400>  10

Met Lys Lys Tyr Leu Leu Gly Ile Gly Leu Ile Leu Ala Leu Ile Ala 
1               5                   10                  15      


Cys Lys Gln Asn Val Ser Ser Leu Asp Glu Lys Asn Ser Val Ser Val 
            20                  25                  30          


Asp Leu Pro Gly Gly Met Lys Val Leu Val Ser Lys Glu Lys Asp Lys 
        35                  40                  45              


Asp Gly Lys Tyr Ser Leu Met Ala Thr Val Glu Lys Leu Glu Leu Lys 
    50                  55                  60                  


Gly Thr Ser Asp Lys Asn Asn Gly Ser Gly Thr Leu Glu Gly Glu Lys 
65                  70                  75                  80  


Thr Asp Lys Ser Lys Val Lys Leu Thr Ile Ala Glu Asp Leu Ser Lys 
                85                  90                  95      


Thr Thr Phe Glu Ile Phe Lys Glu Asp Gly Lys Thr Leu Val Ser Lys 
            100                 105                 110         


Lys Val Thr Leu Lys Asp Lys Ser Ser Thr Glu Glu Lys Phe Asn Glu 
        115                 120                 125             


Lys Gly Glu Ile Ser Glu Lys Thr Ile Val Arg Ala Asn Gly Thr Arg 
    130                 135                 140                 


Leu Glu Tyr Thr Asp Ile Lys Ser Asp Lys Thr Gly Lys Ala Lys Glu 
145                 150                 155                 160 


Val Leu Lys Asp Phe Thr Leu Glu Gly Thr Leu Ala Ala Asp Gly Lys 
                165                 170                 175     


Thr Thr Leu Lys Val Thr Glu Gly Thr Val Thr Leu Ser Lys Asn Ile 
            180                 185                 190         


Ser Lys Ser Gly Glu Ile Thr Val Ala Leu Asp Asp Thr Asp Ser Ser 
        195                 200                 205             


Gly Asn Lys Lys Ser Gly Thr Trp Asp Ser Gly Thr Ser Thr Leu Thr 
    210                 215                 220                 


Ile Ser Lys Asn Arg Thr Lys Thr Lys Gln Leu Val Phe Thr Lys Glu 
225                 230                 235                 240 


Asp Thr Ile Thr Val Gln Asn Tyr Asp Ser Ala Gly Thr Asn Leu Glu 
                245                 250                 255     


Gly Lys Ala Val Glu Ile Thr Thr Leu Lys Glu Leu Lys Asn Ala Leu 
            260                 265                 270         


Lys 
    


<210>  11
<211>  274
<212>  PRT
<213>  Borrelia garinii

<400>  11

Met Lys Lys Tyr Leu Leu Gly Ile Gly Leu Ile Leu Ala Leu Ile Ala 
1               5                   10                  15      


Cys Lys Gln Asn Val Ser Ser Leu Asp Glu Lys Asn Ser Val Ser Val 
            20                  25                  30          


Asp Leu Pro Gly Gly Met Thr Val Leu Val Ser Lys Glu Lys Asp Lys 
        35                  40                  45              


Asp Gly Lys Tyr Ser Leu Glu Ala Thr Val Asp Lys Leu Glu Leu Lys 
    50                  55                  60                  


Gly Thr Ser Asp Lys Asn Asn Gly Ser Gly Thr Leu Glu Gly Glu Lys 
65                  70                  75                  80  


Thr Asp Lys Ser Lys Val Lys Ser Thr Ile Ala Asp Asp Leu Ser Gln 
                85                  90                  95      


Thr Lys Phe Glu Ile Phe Lys Glu Asp Gly Lys Thr Leu Val Ser Lys 
            100                 105                 110         


Lys Val Thr Leu Lys Asp Lys Ser Ser Thr Glu Glu Lys Phe Asn Gly 
        115                 120                 125             


Lys Gly Glu Thr Ser Glu Lys Thr Ile Val Arg Ala Asn Gly Thr Arg 
    130                 135                 140                 


Leu Glu Tyr Thr Asp Ile Lys Ser Asp Gly Ser Gly Lys Ala Lys Glu 
145                 150                 155                 160 


Val Leu Lys Asp Phe Thr Leu Glu Gly Thr Leu Ala Ala Asp Gly Lys 
                165                 170                 175     


Thr Thr Leu Lys Val Thr Glu Gly Thr Val Val Leu Ser Lys Asn Ile 
            180                 185                 190         


Leu Lys Ser Gly Glu Ile Thr Ala Ala Leu Asp Asp Ser Asp Thr Thr 
        195                 200                 205             


Arg Ala Thr Lys Lys Thr Gly Lys Trp Asp Ser Lys Thr Ser Thr Leu 
    210                 215                 220                 


Thr Ile Ser Val Asn Ser Gln Lys Thr Lys Asn Leu Val Phe Thr Lys 
225                 230                 235                 240 


Glu Asp Thr Ile Thr Val Gln Arg Tyr Asp Ser Ala Gly Thr Asn Leu 
                245                 250                 255     


Glu Gly Lys Ala Val Glu Ile Thr Thr Leu Lys Glu Leu Lys Asn Ala 
            260                 265                 270         


Leu Lys 
        


<210>  12
<211>  274
<212>  PRT
<213>  Borrelia garinii

<400>  12

Met Lys Lys Tyr Leu Leu Gly Ile Gly Leu Ile Leu Ala Leu Ile Ala 
1               5                   10                  15      


Cys Lys Gln Asn Val Ser Ser Leu Asp Glu Lys Asn Ser Val Ser Val 
            20                  25                  30          


Asp Leu Pro Gly Glu Met Lys Val Leu Val Ser Lys Glu Lys Asp Lys 
        35                  40                  45              


Asp Gly Lys Tyr Ser Leu Glu Ala Thr Val Asp Lys Leu Glu Leu Lys 
    50                  55                  60                  


Gly Thr Ser Asp Lys Asn Asn Gly Ser Gly Val Leu Glu Gly Val Lys 
65                  70                  75                  80  


Ala Ala Lys Ser Lys Ala Lys Leu Thr Ile Ala Asp Asp Leu Ser Gln 
                85                  90                  95      


Thr Lys Phe Glu Ile Phe Lys Glu Asp Gly Lys Thr Leu Val Ser Lys 
            100                 105                 110         


Lys Val Thr Leu Lys Asp Lys Ser Ser Thr Glu Glu Lys Phe Asn Asp 
        115                 120                 125             


Lys Gly Lys Leu Ser Glu Lys Val Val Thr Arg Ala Asn Gly Thr Arg 
    130                 135                 140                 


Leu Glu Tyr Thr Glu Ile Gln Asn Asp Gly Ser Gly Lys Ala Lys Glu 
145                 150                 155                 160 


Val Leu Lys Ser Leu Thr Leu Glu Gly Thr Leu Thr Ala Asp Gly Glu 
                165                 170                 175     


Thr Lys Leu Thr Val Glu Ala Gly Thr Val Thr Leu Ser Lys Asn Ile 
            180                 185                 190         


Ser Glu Ser Gly Glu Ile Thr Val Glu Leu Lys Asp Thr Glu Thr Thr 
        195                 200                 205             


Pro Ala Asp Lys Lys Ser Gly Thr Trp Asp Ser Lys Thr Ser Thr Leu 
    210                 215                 220                 


Thr Ile Ser Lys Asn Ser Gln Lys Thr Lys Gln Leu Val Phe Thr Lys 
225                 230                 235                 240 


Glu Asn Thr Ile Thr Val Gln Lys Tyr Asn Thr Ala Gly Thr Lys Leu 
                245                 250                 255     


Glu Gly Ser Pro Ala Glu Ile Lys Asp Leu Glu Ala Leu Lys Ala Ala 
            260                 265                 270         


Leu Lys 
        


<210>  13
<211>  16
<212>  PRT
<213>  Borrelia burgdorferi

<400>  13

Met Lys Lys Tyr Leu Leu Gly Ile Gly Leu Ile Leu Ala Leu Ile Ala 
1               5                   10                  15      


<210>  14
<211>  15
<212>  PRT
<213>  Borrelia burgdorferi

<400>  14

Met Arg Leu Leu Ile Gly Phe Ala Leu Ala Leu Ala Leu Ile Gly 
1               5                   10                  15  


<210>  15
<211>  20
<212>  PRT
<213>  Escherichia coli

<400>  15

Met Lys Ala Thr Lys Leu Val Leu Gly Ala Val Ile Leu Gly Ser Thr 
1               5                   10                  15      


Leu Leu Ala Gly 
            20  


<210>  16
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LN1 peptide linker

<400>  16

Gly Thr Ser Asp Lys Asn Asn Gly Ser Gly Ser Lys Glu Lys Asn Lys 
1               5                   10                  15      


Asp Gly Lys Tyr Ser 
            20      


<210>  17
<211>  11
<212>  PRT
<213>  Borrelia burgdorferi

<400>  17

Gly Tyr Val Leu Glu Gly Thr Leu Thr Ala Glu 
1               5                   10      


<210>  18
<211>  11
<212>  PRT
<213>  Borrelia afzelii

<400>  18

Asn Phe Thr Leu Glu Gly Lys Val Ala Asn Asp 
1               5                   10      


<210>  19
<211>  148
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B. burgdorferi OspA 126-273 with replaced hLFA-like sequence

<400>  19

Phe Asn Glu Lys Gly Glu Leu Ser Ala Lys Thr Met Thr Arg Glu Asn 
1               5                   10                  15      


Gly Thr Lys Leu Glu Tyr Thr Glu Met Lys Ser Asp Gly Thr Gly Lys 
            20                  25                  30          


Ala Lys Glu Val Leu Lys Asn Phe Thr Leu Glu Gly Lys Val Ala Asn 
        35                  40                  45              


Asp Lys Val Thr Leu Glu Val Lys Glu Gly Thr Val Thr Leu Ser Lys 
    50                  55                  60                  


Glu Ile Ala Lys Ser Gly Glu Val Thr Val Ala Leu Asn Asp Thr Asn 
65                  70                  75                  80  


Thr Thr Gln Ala Thr Lys Lys Thr Gly Ala Trp Asp Ser Lys Thr Ser 
                85                  90                  95      


Thr Leu Thr Ile Ser Val Asn Ser Lys Lys Thr Thr Gln Leu Val Phe 
            100                 105                 110         


Thr Lys Gln Asp Thr Ile Thr Val Gln Lys Tyr Asp Ser Ala Gly Thr 
        115                 120                 125             


Asn Leu Glu Gly Thr Ala Val Glu Ile Lys Thr Leu Asp Glu Leu Lys 
    130                 135                 140                 


Asn Ala Leu Lys 
145             


<210>  20
<211>  148
<212>  PRT
<213>  Borrelia afzelii

<400>  20

Phe Asn Glu Lys Gly Glu Leu Ser Ala Lys Thr Met Thr Arg Glu Asn 
1               5                   10                  15      


Gly Thr Lys Leu Glu Tyr Thr Glu Met Lys Ser Asp Gly Thr Gly Lys 
            20                  25                  30          


Ala Lys Glu Val Leu Lys Asn Phe Thr Leu Glu Gly Lys Val Ala Asn 
        35                  40                  45              


Asp Lys Val Thr Leu Glu Val Lys Glu Gly Thr Val Thr Leu Ser Lys 
    50                  55                  60                  


Glu Ile Ala Lys Ser Gly Glu Val Thr Val Ala Leu Asn Asp Thr Asn 
65                  70                  75                  80  


Thr Thr Gln Ala Thr Lys Lys Thr Gly Ala Trp Asp Ser Lys Thr Ser 
                85                  90                  95      


Thr Leu Thr Ile Ser Val Asn Ser Lys Lys Thr Thr Gln Leu Val Phe 
            100                 105                 110         


Thr Lys Gln Asp Thr Ile Thr Val Gln Lys Tyr Asp Ser Ala Gly Thr 
        115                 120                 125             


Asn Leu Glu Gly Thr Ala Val Glu Ile Lys Thr Leu Asp Glu Leu Lys 
    130                 135                 140                 


Asn Ala Leu Lys 
145             


<210>  21
<211>  149
<212>  PRT
<213>  Borrelia garinii

<400>  21

Phe Asn Asp Lys Gly Lys Leu Ser Glu Lys Val Val Thr Arg Ala Asn 
1               5                   10                  15      


Gly Thr Arg Leu Glu Tyr Thr Glu Ile Lys Asn Asp Gly Ser Gly Lys 
            20                  25                  30          


Ala Lys Glu Val Leu Lys Gly Phe Ala Leu Glu Gly Thr Leu Thr Asp 
        35                  40                  45              


Gly Gly Glu Thr Lys Leu Thr Val Thr Glu Gly Thr Val Thr Leu Ser 
    50                  55                  60                  


Lys Asn Ile Ser Lys Ser Gly Glu Ile Thr Val Ala Leu Asn Asp Thr 
65                  70                  75                  80  


Glu Thr Thr Pro Ala Asp Lys Lys Thr Gly Glu Trp Lys Ser Asp Thr 
                85                  90                  95      


Ser Thr Leu Thr Ile Ser Lys Asn Ser Gln Lys Pro Lys Gln Leu Val 
            100                 105                 110         


Phe Thr Lys Glu Asn Thr Ile Thr Val Gln Asn Tyr Asn Arg Ala Gly 
        115                 120                 125             


Asn Ala Leu Glu Gly Ser Pro Ala Glu Ile Lys Asp Leu Ala Glu Leu 
    130                 135                 140                 


Lys Ala Ala Leu Lys 
145                 


<210>  22
<211>  148
<212>  PRT
<213>  Borrelia bavariensis

<400>  22

Phe Asn Ala Lys Gly Glu Leu Ser Glu Lys Thr Ile Leu Arg Ala Asn 
1               5                   10                  15      


Gly Thr Arg Leu Glu Tyr Thr Glu Ile Lys Ser Asp Gly Thr Gly Lys 
            20                  25                  30          


Ala Lys Glu Val Leu Lys Asp Phe Ala Leu Glu Gly Thr Leu Ala Ala 
        35                  40                  45              


Asp Lys Thr Thr Leu Lys Val Thr Glu Gly Thr Val Val Leu Ser Lys 
    50                  55                  60                  


His Ile Pro Asn Ser Gly Glu Ile Thr Val Glu Leu Asn Asp Ser Asn 
65                  70                  75                  80  


Ser Thr Gln Ala Thr Lys Lys Thr Gly Lys Trp Asp Ser Asn Thr Ser 
                85                  90                  95      


Thr Leu Thr Ile Ser Val Asn Ser Lys Lys Thr Lys Asn Ile Val Phe 
            100                 105                 110         


Thr Lys Glu Asp Thr Ile Thr Val Gln Lys Tyr Asp Ser Ala Gly Thr 
        115                 120                 125             


Asn Leu Glu Gly Asn Ala Val Glu Ile Lys Thr Leu Asp Glu Leu Lys 
    130                 135                 140                 


Asn Ala Leu Lys 
145             


<210>  23
<211>  148
<212>  PRT
<213>  Borrelia garinii

<400>  23

Phe Asn Glu Lys Gly Glu Ile Ser Glu Lys Thr Ile Val Arg Ala Asn 
1               5                   10                  15      


Gly Thr Arg Leu Glu Tyr Thr Asp Ile Lys Ser Asp Lys Thr Gly Lys 
            20                  25                  30          


Ala Lys Glu Val Leu Lys Asp Phe Thr Leu Glu Gly Thr Leu Ala Ala 
        35                  40                  45              


Asp Gly Lys Thr Thr Leu Lys Val Thr Glu Gly Thr Val Thr Leu Ser 
    50                  55                  60                  


Lys Asn Ile Ser Lys Ser Gly Glu Ile Thr Val Ala Leu Asp Asp Thr 
65                  70                  75                  80  


Asp Ser Ser Gly Asn Lys Lys Ser Gly Thr Trp Asp Ser Gly Thr Ser 
                85                  90                  95      


Thr Leu Thr Ile Ser Lys Asn Arg Thr Lys Thr Lys Gln Leu Val Phe 
            100                 105                 110         


Thr Lys Glu Asp Thr Ile Thr Val Gln Asn Tyr Asp Ser Ala Gly Thr 
        115                 120                 125             


Asn Leu Glu Gly Lys Ala Val Glu Ile Thr Thr Leu Lys Glu Leu Lys 
    130                 135                 140                 


Asn Ala Leu Lys 
145             


<210>  24
<211>  149
<212>  PRT
<213>  Borrelia garinii

<400>  24

Phe Asn Gly Lys Gly Glu Thr Ser Glu Lys Thr Ile Val Arg Ala Asn 
1               5                   10                  15      


Gly Thr Arg Leu Glu Tyr Thr Asp Ile Lys Ser Asp Gly Ser Gly Lys 
            20                  25                  30          


Ala Lys Glu Val Leu Lys Asp Phe Thr Leu Glu Gly Thr Leu Ala Ala 
        35                  40                  45              


Asp Gly Lys Thr Thr Leu Lys Val Thr Glu Gly Thr Val Val Leu Ser 
    50                  55                  60                  


Lys Asn Ile Leu Lys Ser Gly Glu Ile Thr Ala Ala Leu Asp Asp Ser 
65                  70                  75                  80  


Asp Thr Thr Arg Ala Thr Lys Lys Thr Gly Lys Trp Asp Ser Lys Thr 
                85                  90                  95      


Ser Thr Leu Thr Ile Ser Val Asn Ser Gln Lys Thr Lys Asn Leu Val 
            100                 105                 110         


Phe Thr Lys Glu Asp Thr Ile Thr Val Gln Arg Tyr Asp Ser Ala Gly 
        115                 120                 125             


Thr Asn Leu Glu Gly Lys Ala Val Glu Ile Thr Thr Leu Lys Glu Leu 
    130                 135                 140                 


Lys Asn Ala Leu Lys 
145                 


<210>  25
<211>  149
<212>  PRT
<213>  Borrelia garinii

<400>  25

Phe Asn Asp Lys Gly Lys Leu Ser Glu Lys Val Val Thr Arg Ala Asn 
1               5                   10                  15      


Gly Thr Arg Leu Glu Tyr Thr Glu Ile Gln Asn Asp Gly Ser Gly Lys 
            20                  25                  30          


Ala Lys Glu Val Leu Lys Ser Leu Thr Leu Glu Gly Thr Leu Thr Ala 
        35                  40                  45              


Asp Gly Glu Thr Lys Leu Thr Val Glu Ala Gly Thr Val Thr Leu Ser 
    50                  55                  60                  


Lys Asn Ile Ser Glu Ser Gly Glu Ile Thr Val Glu Leu Lys Asp Thr 
65                  70                  75                  80  


Glu Thr Thr Pro Ala Asp Lys Lys Ser Gly Thr Trp Asp Ser Lys Thr 
                85                  90                  95      


Ser Thr Leu Thr Ile Ser Lys Asn Ser Gln Lys Thr Lys Gln Leu Val 
            100                 105                 110         


Phe Thr Lys Glu Asn Thr Ile Thr Val Gln Lys Tyr Asn Thr Ala Gly 
        115                 120                 125             


Thr Lys Leu Glu Gly Ser Pro Ala Glu Ile Lys Asp Leu Glu Ala Leu 
    130                 135                 140                 


Lys Ala Ala Leu Lys 
145                 


<210>  26
<211>  1029
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Lip-S4D1-S3hybD1-nt

<400>  26
atgaaagcta ctaaactggt actgggcgcg gtaatcctgg gttctactct gctggcaggt       60

tgctcaagct tcaatgctaa gggcgaactg agcgaaaaaa cgatcctgcg tgcgaatggc      120

acccgtctgg aatacaccga aatcaaatcc gatggtacgg gcaaagcaaa ggaagtcctg      180

aaagattttg ctctggaagg taccctggcg gccgacaaaa ccacgctgaa ggtgacgtgc      240

ggcaccgtgg ttctgagcaa acatattccg aactctggtg aaatcaccgt tgaactgaac      300

gatagcaatt ctacgcaggc aaccaaaaag acgggcaaat gggacagtaa tacctccacg      360

ctgaccattt cagtcaactc gaaaaagacc aaaaatattg tgttcacgaa ggaagatacg      420

atcaccgttc aaaaatatga ctccgcgggc accaacctgg aaggcaatgc cgtcgaaatc      480

aaaaccctgg atgaactgtg taacgccctg aagggtacta gtgacaaaaa caatggctct      540

ggtagcaaag agaaaaacaa agatggcaag tactcattca acgaaaaagg cgaagtgagc      600

gaaaaaattc tgacccgtag caatggcacc accctggaat atagccagat gaccgatgca      660

gaaaatgcaa ccaaagcagt tgaaaccctg aaaaacggta ttaaactgcc tggtaatctg      720

gttggtggta aaaccaaact gaccgttacc tgtggcaccg ttaccctgag caaaaacatt      780

agcaaaagcg gtgaaattac cgtggcactg aatgataccg aaaccacacc ggcagacaaa      840

aaaaccggtg aatggaaaag cgataccagc accctgacca ttagtaaaaa tagccagaaa      900

acaaaacagc tggtgtttac caaagaaaac accattaccg tgcagaatta taaccgtgca      960

ggtaatgcac tggaaggtag tccggcagaa attaaagatc tggcagaact gtgtgcagcc     1020

ctgaaataa                                                             1029


<210>  27
<211>  322
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lip-S4D1-S3hybD1-aa


<220>
<221>  LIPID
<222>  (1)..(1)

<400>  27

Cys Ser Ser Phe Asn Ala Lys Gly Glu Leu Ser Glu Lys Thr Ile Leu 
1               5                   10                  15      


Arg Ala Asn Gly Thr Arg Leu Glu Tyr Thr Glu Ile Lys Ser Asp Gly 
            20                  25                  30          


Thr Gly Lys Ala Lys Glu Val Leu Lys Asp Phe Ala Leu Glu Gly Thr 
        35                  40                  45              


Leu Ala Ala Asp Lys Thr Thr Leu Lys Val Thr Cys Gly Thr Val Val 
    50                  55                  60                  


Leu Ser Lys His Ile Pro Asn Ser Gly Glu Ile Thr Val Glu Leu Asn 
65                  70                  75                  80  


Asp Ser Asn Ser Thr Gln Ala Thr Lys Lys Thr Gly Lys Trp Asp Ser 
                85                  90                  95      


Asn Thr Ser Thr Leu Thr Ile Ser Val Asn Ser Lys Lys Thr Lys Asn 
            100                 105                 110         


Ile Val Phe Thr Lys Glu Asp Thr Ile Thr Val Gln Lys Tyr Asp Ser 
        115                 120                 125             


Ala Gly Thr Asn Leu Glu Gly Asn Ala Val Glu Ile Lys Thr Leu Asp 
    130                 135                 140                 


Glu Leu Cys Asn Ala Leu Lys Gly Thr Ser Asp Lys Asn Asn Gly Ser 
145                 150                 155                 160 


Gly Ser Lys Glu Lys Asn Lys Asp Gly Lys Tyr Ser Phe Asn Glu Lys 
                165                 170                 175     


Gly Glu Val Ser Glu Lys Ile Leu Thr Arg Ser Asn Gly Thr Thr Leu 
            180                 185                 190         


Glu Tyr Ser Gln Met Thr Asp Ala Glu Asn Ala Thr Lys Ala Val Glu 
        195                 200                 205             


Thr Leu Lys Asn Gly Ile Lys Leu Pro Gly Asn Leu Val Gly Gly Lys 
    210                 215                 220                 


Thr Lys Leu Thr Val Thr Cys Gly Thr Val Thr Leu Ser Lys Asn Ile 
225                 230                 235                 240 


Ser Lys Ser Gly Glu Ile Thr Val Ala Leu Asn Asp Thr Glu Thr Thr 
                245                 250                 255     


Pro Ala Asp Lys Lys Thr Gly Glu Trp Lys Ser Asp Thr Ser Thr Leu 
            260                 265                 270         


Thr Ile Ser Lys Asn Ser Gln Lys Thr Lys Gln Leu Val Phe Thr Lys 
        275                 280                 285             


Glu Asn Thr Ile Thr Val Gln Asn Tyr Asn Arg Ala Gly Asn Ala Leu 
    290                 295                 300                 


Glu Gly Ser Pro Ala Glu Ile Lys Asp Leu Ala Glu Leu Cys Ala Ala 
305                 310                 315                 320 


Leu Lys 
        


<210>  28
<211>  1020
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Lip-S1D1-S2D1-nt

<400>  28
atgaaagcta ctaaactggt actgggcgcg gtaatcctgg gttctactct gctggcaggt       60

tgctcaagct tcaacgaaaa gggcgaagtc agcgaaaaaa tcattacccg cgcagacggc      120

acccgcctgg aatacaccgg catcaaatcg gacggcagcg gcaaagcgaa agaagttctg      180

aaaaacttta ccctggaagg caaagtcgca aatgataaaa ccaccctggt ggtgaaatgc      240

ggcaccgtta cgctgagcaa aaacattagt aaatccggtg aagtctctgt ggaactgaat      300

gataccgaca gctctgcggc caccaagaaa accgcagctt ggaactcagg cacctcgacg      360

ctgaccatta cggttaatag caagaaaacc aaagatctgg tcttcacgaa agaaaacacc      420

atcacggtgc agcaatatga cagcaatggt accaaactgg aaggctccgc tgtggaaatc      480

acgaaactgg atgaaatctg taatgctctg aaaggtacta gtgacaaaaa caatggctct      540

ggtagcaaag agaaaaacaa agatggcaag tactcattca acgaaaaagg cgaactgtcg      600

gcgaaaacga tgacgcgtga aaacggcacc aaactggaat atacggaaat gaaaagcgat      660

ggcaccggta aagcgaaaga agttctgaaa aactttaccc tggaaggcaa agtcgccaat      720

gacaaagtca ccctggaagt gaaatgcggc accgttacgc tgtcaaaaga aattgcaaaa      780

tcgggtgaag tgaccgttgc tctgaacgat acgaatacca cgcaagcgac caagaaaacc      840

ggcgcctggg acagcaaaac ctctacgctg accattagtg ttaatagcaa gaaaaccacg      900

cagctggtct tcaccaaaca agatacgatc accgtgcaga aatacgacag tgcgggtacc      960

aacctggaag gcacggctgt tgaaatcaaa accctggacg aactgtgtaa cgccctgaaa     1020


<210>  29
<211>  320
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lip-S1D1-S2D1-aa


<220>
<221>  LIPID
<222>  (1)..(1)

<400>  29

Cys Ser Ser Phe Asn Glu Lys Gly Glu Val Ser Glu Lys Ile Ile Thr 
1               5                   10                  15      


Arg Ala Asp Gly Thr Arg Leu Glu Tyr Thr Gly Ile Lys Ser Asp Gly 
            20                  25                  30          


Ser Gly Lys Ala Lys Glu Val Leu Lys Asn Phe Thr Leu Glu Gly Lys 
        35                  40                  45              


Val Ala Asn Asp Lys Thr Thr Leu Val Val Lys Cys Gly Thr Val Thr 
    50                  55                  60                  


Leu Ser Lys Asn Ile Ser Lys Ser Gly Glu Val Ser Val Glu Leu Asn 
65                  70                  75                  80  


Asp Thr Asp Ser Ser Ala Ala Thr Lys Lys Thr Ala Ala Trp Asn Ser 
                85                  90                  95      


Gly Thr Ser Thr Leu Thr Ile Thr Val Asn Ser Lys Lys Thr Lys Asp 
            100                 105                 110         


Leu Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln Gln Tyr Asp Ser 
        115                 120                 125             


Asn Gly Thr Lys Leu Glu Gly Ser Ala Val Glu Ile Thr Lys Leu Asp 
    130                 135                 140                 


Glu Ile Cys Asn Ala Leu Lys Gly Thr Ser Asp Lys Asn Asn Gly Ser 
145                 150                 155                 160 


Gly Ser Lys Glu Lys Asn Lys Asp Gly Lys Tyr Ser Phe Asn Glu Lys 
                165                 170                 175     


Gly Glu Leu Ser Ala Lys Thr Met Thr Arg Glu Asn Gly Thr Lys Leu 
            180                 185                 190         


Glu Tyr Thr Glu Met Lys Ser Asp Gly Thr Gly Lys Ala Lys Glu Val 
        195                 200                 205             


Leu Lys Asn Phe Thr Leu Glu Gly Lys Val Ala Asn Asp Lys Val Thr 
    210                 215                 220                 


Leu Glu Val Lys Cys Gly Thr Val Thr Leu Ser Lys Glu Ile Ala Lys 
225                 230                 235                 240 


Ser Gly Glu Val Thr Val Ala Leu Asn Asp Thr Asn Thr Thr Gln Ala 
                245                 250                 255     


Thr Lys Lys Thr Gly Ala Trp Asp Ser Lys Thr Ser Thr Leu Thr Ile 
            260                 265                 270         


Ser Val Asn Ser Lys Lys Thr Thr Gln Leu Val Phe Thr Lys Gln Asp 
        275                 280                 285             


Thr Ile Thr Val Gln Lys Tyr Asp Ser Ala Gly Thr Asn Leu Glu Gly 
    290                 295                 300                 


Thr Ala Val Glu Ile Lys Thr Leu Asp Glu Leu Cys Asn Ala Leu Lys 
305                 310                 315                 320 


<210>  30
<211>  1023
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Lip-S4D1-S3D1-nt

<400>  30
atgaaagcta ctaaactggt actgggcgcg gtaatcctgg gttctactct gctggcaggt       60

tgctcaagct tcaatgctaa gggcgaactg agcgaaaaaa cgatcctgcg tgcgaatggc      120

acccgtctgg aatacaccga aatcaaatcc gatggtacgg gcaaagcaaa ggaagtcctg      180

aaagattttg ctctggaagg taccctggcg gccgacaaaa ccacgctgaa ggtgacgtgc      240

ggcaccgtgg ttctgagcaa acatattccg aactctggtg aaatcaccgt tgaactgaac      300

gatagcaatt ctacgcaggc aaccaaaaag acgggcaaat gggacagtaa tacctccacg      360

ctgaccattt cagtcaactc gaaaaagacc aaaaatattg tgttcacgaa ggaagatacg      420

atcaccgttc aaaaatatga ctccgcgggc accaacctgg aaggcaatgc cgtcgaaatc      480

aaaaccctgg atgaactgtg taacgccctg aagggtacta gtgacaaaaa caatggctct      540

ggtagcaaag agaaaaacaa agatggcaag tactcattta acgataaggg caaactgtcg      600

gaaaaagtgg tcacccgcgc aaatggcacc cgcctggaat acacggaaat caaaaacgat      660

ggtagcggca aagcgaagga agttctgaaa ggctttgccc tggaaggtac cctgacggat      720

ggcggtgaaa ccaaactgac cgtgacgtgc ggcaccgtta cgctgtctaa aaacattagc      780

aagtctggtg aaatcacggt cgcactgaat gataccgaaa ccacgccggc tgacaaaaag      840

accggcgaat ggaaaagtga cacctccacg ctgaccattt caaagaactc gcagaaaccg      900

aagcaactgg tcttcaccaa agaaaacacg atcaccgtgc agaactataa tcgtgccggt      960

aatgctctgg aaggctcacc ggctgaaatc aaggacctgg ctgaactgtg tgcggcactg     1020

aaa                                                                   1023


<210>  31
<211>  321
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lip-S4D1-S3D1-aa


<220>
<221>  LIPID
<222>  (1)..(1)

<400>  31

Cys Ser Ser Phe Asn Ala Lys Gly Glu Leu Ser Glu Lys Thr Ile Leu 
1               5                   10                  15      


Arg Ala Asn Gly Thr Arg Leu Glu Tyr Thr Glu Ile Lys Ser Asp Gly 
            20                  25                  30          


Thr Gly Lys Ala Lys Glu Val Leu Lys Asp Phe Ala Leu Glu Gly Thr 
        35                  40                  45              


Leu Ala Ala Asp Lys Thr Thr Leu Lys Val Thr Cys Gly Thr Val Val 
    50                  55                  60                  


Leu Ser Lys His Ile Pro Asn Ser Gly Glu Ile Thr Val Glu Leu Asn 
65                  70                  75                  80  


Asp Ser Asn Ser Thr Gln Ala Thr Lys Lys Thr Gly Lys Trp Asp Ser 
                85                  90                  95      


Asn Thr Ser Thr Leu Thr Ile Ser Val Asn Ser Lys Lys Thr Lys Asn 
            100                 105                 110         


Ile Val Phe Thr Lys Glu Asp Thr Ile Thr Val Gln Lys Tyr Asp Ser 
        115                 120                 125             


Ala Gly Thr Asn Leu Glu Gly Asn Ala Val Glu Ile Lys Thr Leu Asp 
    130                 135                 140                 


Glu Leu Cys Asn Ala Leu Lys Gly Thr Ser Asp Lys Asn Asn Gly Ser 
145                 150                 155                 160 


Gly Ser Lys Glu Lys Asn Lys Asp Gly Lys Tyr Ser Phe Asn Asp Lys 
                165                 170                 175     


Gly Lys Leu Ser Glu Lys Val Val Thr Arg Ala Asn Gly Thr Arg Leu 
            180                 185                 190         


Glu Tyr Thr Glu Ile Lys Asn Asp Gly Ser Gly Lys Ala Lys Glu Val 
        195                 200                 205             


Leu Lys Gly Phe Ala Leu Glu Gly Thr Leu Thr Asp Gly Gly Glu Thr 
    210                 215                 220                 


Lys Leu Thr Val Thr Cys Gly Thr Val Thr Leu Ser Lys Asn Ile Ser 
225                 230                 235                 240 


Lys Ser Gly Glu Ile Thr Val Ala Leu Asn Asp Thr Glu Thr Thr Pro 
                245                 250                 255     


Ala Asp Lys Lys Thr Gly Glu Trp Lys Ser Asp Thr Ser Thr Leu Thr 
            260                 265                 270         


Ile Ser Lys Asn Ser Gln Lys Pro Lys Gln Leu Val Phe Thr Lys Glu 
        275                 280                 285             


Asn Thr Ile Thr Val Gln Asn Tyr Asn Arg Ala Gly Asn Ala Leu Glu 
    290                 295                 300                 


Gly Ser Pro Ala Glu Ile Lys Asp Leu Ala Glu Leu Cys Ala Ala Leu 
305                 310                 315                 320 


Lys 
    


<210>  32
<211>  1023
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Lip-S5D1-S6D1-nt

<400>  32
atgaaagcta ctaaactggt actgggcgcg gtaatcctgg gttctactct gctggcaggt       60

tgctcaagct tcaacgaaaa gggcgaaatc tcagaaaaaa ccatcgtccg cgctaacggc      120

acccgcctgg aatacaccga catcaaatca gacaagaccg gtaaagcgaa ggaagttctg      180

aaagatttta cgctggaagg taccctggca gcagacggta aaaccacgct gaaggtgacc      240

tgcggtaccg ttacgctgtc caaaaacatt agtaagtccg gcgaaatcac ggtcgccctg      300

gatgacaccg atagctctgg caacaaaaag agcggtacct gggattcagg cacctcgacg      360

ctgaccattt ctaaaaatcg tacgaaaacc aagcagctgg tcttcacgaa agaagatacg      420

atcaccgtgc aaaactatga cagcgcaggt accaatctgg aaggcaaagc tgtggaaatt      480

accacgctga aagaactgtg taatgctctg aaaggtacta gtgacaaaaa caatggctct      540

ggtagcaaag agaaaaacaa agatggcaag tactcattca acggcaaagg tgaaacgagc      600

gaaaagacca tcgtgcgtgc gaacggtacc cgcctggaat atacggacat taaatcggac      660

ggcagcggca aagcaaagga agtcctgaaa gattttacgc tggaaggtac cctggcagca      720

gacggtaaaa ccacgctgaa ggtgacgtgc ggcaccgtgg ttctgtcaaa aaacattctg      780

aagtcgggtg aaatcaccgc agctctggat gacagcgata ccacgcgtgc tacgaaaaag      840

accggtaaat gggatagcaa gacctctacg ctgaccatta gtgtcaactc ccagaaaacg      900

aagaatctgg tgttcaccaa agaagatacg atcaccgttc aacgctatga cagtgcgggc      960

accaacctgg aaggcaaagc cgttgaaatt accacgctga aagaactgtg taatgctctg     1020

aaa                                                                   1023


<210>  33
<211>  321
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lip-S5D1-S6D1-aa


<220>
<221>  LIPID
<222>  (1)..(1)

<400>  33

Cys Ser Ser Phe Asn Glu Lys Gly Glu Ile Ser Glu Lys Thr Ile Val 
1               5                   10                  15      


Arg Ala Asn Gly Thr Arg Leu Glu Tyr Thr Asp Ile Lys Ser Asp Lys 
            20                  25                  30          


Thr Gly Lys Ala Lys Glu Val Leu Lys Asp Phe Thr Leu Glu Gly Thr 
        35                  40                  45              


Leu Ala Ala Asp Gly Lys Thr Thr Leu Lys Val Thr Cys Gly Thr Val 
    50                  55                  60                  


Thr Leu Ser Lys Asn Ile Ser Lys Ser Gly Glu Ile Thr Val Ala Leu 
65                  70                  75                  80  


Asp Asp Thr Asp Ser Ser Gly Asn Lys Lys Ser Gly Thr Trp Asp Ser 
                85                  90                  95      


Gly Thr Ser Thr Leu Thr Ile Ser Lys Asn Arg Thr Lys Thr Lys Gln 
            100                 105                 110         


Leu Val Phe Thr Lys Glu Asp Thr Ile Thr Val Gln Asn Tyr Asp Ser 
        115                 120                 125             


Ala Gly Thr Asn Leu Glu Gly Lys Ala Val Glu Ile Thr Thr Leu Lys 
    130                 135                 140                 


Glu Leu Cys Asn Ala Leu Lys Gly Thr Ser Asp Lys Asn Asn Gly Ser 
145                 150                 155                 160 


Gly Ser Lys Glu Lys Asn Lys Asp Gly Lys Tyr Ser Phe Asn Gly Lys 
                165                 170                 175     


Gly Glu Thr Ser Glu Lys Thr Ile Val Arg Ala Asn Gly Thr Arg Leu 
            180                 185                 190         


Glu Tyr Thr Asp Ile Lys Ser Asp Gly Ser Gly Lys Ala Lys Glu Val 
        195                 200                 205             


Leu Lys Asp Phe Thr Leu Glu Gly Thr Leu Ala Ala Asp Gly Lys Thr 
    210                 215                 220                 


Thr Leu Lys Val Thr Cys Gly Thr Val Val Leu Ser Lys Asn Ile Leu 
225                 230                 235                 240 


Lys Ser Gly Glu Ile Thr Ala Ala Leu Asp Asp Ser Asp Thr Thr Arg 
                245                 250                 255     


Ala Thr Lys Lys Thr Gly Lys Trp Asp Ser Lys Thr Ser Thr Leu Thr 
            260                 265                 270         


Ile Ser Val Asn Ser Gln Lys Thr Lys Asn Leu Val Phe Thr Lys Glu 
        275                 280                 285             


Asp Thr Ile Thr Val Gln Arg Tyr Asp Ser Ala Gly Thr Asn Leu Glu 
    290                 295                 300                 


Gly Lys Ala Val Glu Ile Thr Thr Leu Lys Glu Leu Cys Asn Ala Leu 
305                 310                 315                 320 


Lys 
    


<210>  34
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B. burgdorferi  (strain B31, OspA serotype 1) aa 18-273

<400>  34

Cys Ser Ser Phe Lys Gln Asn Val Ser Ser Leu Asp Glu Lys Asn Ser 
1               5                   10                  15      


Val Ser Val Asp Leu Pro Gly Glu Met Lys Val Leu Val Ser Lys Glu 
            20                  25                  30          


Lys Asn Lys Asp Gly Lys Tyr Asp Leu Ile Ala Thr Val Asp Lys Leu 
        35                  40                  45              


Glu Leu Lys Gly Thr Ser Asp Lys Asn Asn Gly Ser Gly Val Leu Glu 
    50                  55                  60                  


Gly Val Lys Ala Asp Lys Ser Lys Val Lys Leu Thr Ile Ser Asp Asp 
65                  70                  75                  80  


Leu Gly Gln Thr Thr Leu Glu Val Phe Lys Glu Asp Gly Lys Thr Leu 
                85                  90                  95      


Val Ser Lys Lys Val Thr Ser Lys Asp Lys Ser Ser Thr Glu Glu Lys 
            100                 105                 110         


Phe Asn Glu Lys Gly Glu Val Ser Glu Lys Ile Ile Thr Arg Ala Asp 
        115                 120                 125             


Gly Thr Arg Leu Glu Tyr Thr Gly Ile Lys Ser Asp Gly Ser Gly Lys 
    130                 135                 140                 


Ala Lys Glu Val Leu Lys Gly Tyr Val Leu Glu Gly Thr Leu Thr Ala 
145                 150                 155                 160 


Glu Lys Thr Thr Leu Val Val Lys Glu Gly Thr Val Thr Leu Ser Lys 
                165                 170                 175     


Asn Ile Ser Lys Ser Gly Glu Val Ser Val Glu Leu Asn Asp Thr Asp 
            180                 185                 190         


Ser Ser Ala Ala Thr Lys Lys Thr Ala Ala Trp Asn Ser Gly Thr Ser 
        195                 200                 205             


Thr Leu Thr Ile Thr Val Asn Ser Lys Lys Thr Lys Asp Leu Val Phe 
    210                 215                 220                 


Thr Lys Glu Asn Thr Ile Thr Val Gln Gln Tyr Asp Ser Asn Gly Thr 
225                 230                 235                 240 


Lys Leu Glu Gly Ser Ala Val Glu Ile Thr Lys Leu Asp Glu Ile Lys 
                245                 250                 255     


Asn Ala Leu Lys Leu Glu His His His His His His 
            260                 265             


<210>  35
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B. afzelii (strain K78; OspA serotype 2) aa 18-273

<400>  35

Cys Ser Ser Phe Lys Gln Asn Val Ser Ser Leu Asp Glu Lys Asn Ser 
1               5                   10                  15      


Ala Ser Val Asp Leu Pro Gly Glu Met Lys Val Leu Val Ser Lys Glu 
            20                  25                  30          


Lys Asp Lys Asp Gly Lys Tyr Ser Leu Lys Ala Thr Val Asp Lys Ile 
        35                  40                  45              


Glu Leu Lys Gly Thr Ser Asp Lys Asp Asn Gly Ser Gly Val Leu Glu 
    50                  55                  60                  


Gly Thr Lys Asp Asp Lys Ser Lys Ala Lys Leu Thr Ile Ala Asp Asp 
65                  70                  75                  80  


Leu Ser Lys Thr Thr Phe Glu Leu Phe Lys Glu Asp Gly Lys Thr Leu 
                85                  90                  95      


Val Ser Arg Lys Val Ser Ser Lys Asp Lys Thr Ser Thr Asp Glu Met 
            100                 105                 110         


Phe Asn Glu Lys Gly Glu Leu Ser Ala Lys Thr Met Thr Arg Glu Asn 
        115                 120                 125             


Gly Thr Lys Leu Glu Tyr Thr Glu Met Lys Ser Asp Gly Thr Gly Lys 
    130                 135                 140                 


Ala Lys Glu Val Leu Lys Asn Phe Thr Leu Glu Gly Lys Val Ala Asn 
145                 150                 155                 160 


Asp Lys Val Thr Leu Glu Val Lys Glu Gly Thr Val Thr Leu Ser Lys 
                165                 170                 175     


Glu Ile Ala Lys Ser Gly Glu Val Thr Val Ala Leu Asn Asp Thr Asn 
            180                 185                 190         


Thr Thr Gln Ala Thr Lys Lys Thr Gly Ala Trp Asp Ser Lys Thr Ser 
        195                 200                 205             


Thr Leu Thr Ile Ser Val Asn Ser Lys Lys Thr Thr Gln Leu Val Phe 
    210                 215                 220                 


Thr Lys Gln Asp Thr Ile Thr Val Gln Lys Tyr Asp Ser Ala Gly Thr 
225                 230                 235                 240 


Asn Leu Glu Gly Thr Ala Val Glu Ile Lys Thr Leu Asp Glu Leu Lys 
                245                 250                 255     


Asn Ala Leu Lys Leu Glu His His His His His His 
            260                 265             


<210>  36
<211>  269
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B. garinii (strain PBr; OspA serotype 3) aa 18-274

<400>  36

Cys Ser Ser Phe Lys Gln Asn Val Ser Ser Leu Asp Glu Lys Asn Ser 
1               5                   10                  15      


Val Ser Val Asp Leu Pro Gly Gly Met Lys Val Leu Val Ser Lys Glu 
            20                  25                  30          


Lys Asp Lys Asp Gly Lys Tyr Ser Leu Met Ala Thr Val Glu Lys Leu 
        35                  40                  45              


Glu Leu Lys Gly Thr Ser Asp Lys Ser Asn Gly Ser Gly Val Leu Glu 
    50                  55                  60                  


Gly Glu Lys Ala Asp Lys Ser Lys Ala Lys Leu Thr Ile Ser Gln Asp 
65                  70                  75                  80  


Leu Asn Gln Thr Thr Phe Glu Ile Phe Lys Glu Asp Gly Lys Thr Leu 
                85                  90                  95      


Val Ser Arg Lys Val Asn Ser Lys Asp Lys Ser Ser Thr Glu Glu Lys 
            100                 105                 110         


Phe Asn Asp Lys Gly Lys Leu Ser Glu Lys Val Val Thr Arg Ala Asn 
        115                 120                 125             


Gly Thr Arg Leu Glu Tyr Thr Glu Ile Lys Asn Asp Gly Ser Gly Lys 
    130                 135                 140                 


Ala Lys Glu Val Leu Lys Gly Phe Ala Leu Glu Gly Thr Leu Thr Asp 
145                 150                 155                 160 


Gly Gly Glu Thr Lys Leu Thr Val Thr Glu Gly Thr Val Thr Leu Ser 
                165                 170                 175     


Lys Asn Ile Ser Lys Ser Gly Glu Ile Thr Val Ala Leu Asn Asp Thr 
            180                 185                 190         


Glu Thr Thr Pro Ala Asp Lys Lys Thr Gly Glu Trp Lys Ser Asp Thr 
        195                 200                 205             


Ser Thr Leu Thr Ile Ser Lys Asn Ser Gln Lys Thr Lys Gln Leu Val 
    210                 215                 220                 


Phe Thr Lys Glu Asn Thr Ile Thr Val Gln Asn Tyr Asn Arg Ala Gly 
225                 230                 235                 240 


Asn Ala Leu Glu Gly Ser Pro Ala Glu Ile Lys Asp Leu Ala Glu Leu 
                245                 250                 255     


Lys Ala Ala Leu Lys Leu Glu His His His His His His 
            260                 265                 


<210>  37
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B. bavariensis (strain PBi; OspA serotype 4) aa 18-273

<400>  37

Cys Ser Ser Phe Lys Gln Asn Val Ser Ser Leu Asp Glu Lys Asn Ser 
1               5                   10                  15      


Val Ser Val Asp Leu Pro Gly Glu Met Lys Val Leu Val Ser Lys Glu 
            20                  25                  30          


Lys Asp Lys Asp Gly Lys Tyr Ser Leu Met Ala Thr Val Asp Lys Leu 
        35                  40                  45              


Glu Leu Lys Gly Thr Ser Asp Lys Ser Asn Gly Ser Gly Thr Leu Glu 
    50                  55                  60                  


Gly Glu Lys Ser Asp Lys Ser Lys Ala Lys Leu Thr Ile Ser Glu Asp 
65                  70                  75                  80  


Leu Ser Lys Thr Thr Phe Glu Ile Phe Lys Glu Asp Gly Lys Thr Leu 
                85                  90                  95      


Val Ser Lys Lys Val Asn Ser Lys Asp Lys Ser Ser Ile Glu Glu Lys 
            100                 105                 110         


Phe Asn Ala Lys Gly Glu Leu Ser Glu Lys Thr Ile Leu Arg Ala Asn 
        115                 120                 125             


Gly Thr Arg Leu Glu Tyr Thr Glu Ile Lys Ser Asp Gly Thr Gly Lys 
    130                 135                 140                 


Ala Lys Glu Val Leu Lys Asp Phe Ala Leu Glu Gly Thr Leu Ala Ala 
145                 150                 155                 160 


Asp Lys Thr Thr Leu Lys Val Thr Glu Gly Thr Val Val Leu Ser Lys 
                165                 170                 175     


His Ile Pro Asn Ser Gly Glu Ile Thr Val Glu Leu Asn Asp Ser Asn 
            180                 185                 190         


Ser Thr Gln Ala Thr Lys Lys Thr Gly Lys Trp Asp Ser Asn Thr Ser 
        195                 200                 205             


Thr Leu Thr Ile Ser Val Asn Ser Lys Lys Thr Lys Asn Ile Val Phe 
    210                 215                 220                 


Thr Lys Glu Asp Thr Ile Thr Val Gln Lys Tyr Asp Ser Ala Gly Thr 
225                 230                 235                 240 


Asn Leu Glu Gly Asn Ala Val Glu Ile Lys Thr Leu Asp Glu Leu Lys 
                245                 250                 255     


Asn Ala Leu Lys Leu Glu His His His His His His 
            260                 265             


<210>  38
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B. garinii (strain PHei; OspA serotype 5) aa 18-273

<400>  38

Cys Ser Ser Phe Lys Gln Asn Val Ser Ser Leu Asp Glu Lys Asn Ser 
1               5                   10                  15      


Val Ser Val Asp Leu Pro Gly Gly Met Lys Val Leu Val Ser Lys Glu 
            20                  25                  30          


Lys Asp Lys Asp Gly Lys Tyr Ser Leu Met Ala Thr Val Glu Lys Leu 
        35                  40                  45              


Glu Leu Lys Gly Thr Ser Asp Lys Asn Asn Gly Ser Gly Thr Leu Glu 
    50                  55                  60                  


Gly Glu Lys Thr Asp Lys Ser Lys Val Lys Leu Thr Ile Ala Glu Asp 
65                  70                  75                  80  


Leu Ser Lys Thr Thr Phe Glu Ile Phe Lys Glu Asp Gly Lys Thr Leu 
                85                  90                  95      


Val Ser Lys Lys Val Thr Leu Lys Asp Lys Ser Ser Thr Glu Glu Lys 
            100                 105                 110         


Phe Asn Glu Lys Gly Glu Ile Ser Glu Lys Thr Ile Val Arg Ala Asn 
        115                 120                 125             


Gly Thr Arg Leu Glu Tyr Thr Asp Ile Lys Ser Asp Lys Thr Gly Lys 
    130                 135                 140                 


Ala Lys Glu Val Leu Lys Asp Phe Thr Leu Glu Gly Thr Leu Ala Ala 
145                 150                 155                 160 


Asp Gly Lys Thr Thr Leu Lys Val Thr Glu Gly Thr Val Thr Leu Ser 
                165                 170                 175     


Lys Asn Ile Ser Lys Ser Gly Glu Ile Thr Val Ala Leu Asp Asp Thr 
            180                 185                 190         


Asp Ser Ser Gly Asn Lys Lys Ser Gly Thr Trp Asp Ser Gly Thr Ser 
        195                 200                 205             


Thr Leu Thr Ile Ser Lys Asn Arg Thr Lys Thr Lys Gln Leu Val Phe 
    210                 215                 220                 


Thr Lys Glu Asp Thr Ile Thr Val Gln Asn Tyr Asp Ser Ala Gly Thr 
225                 230                 235                 240 


Asn Leu Glu Gly Lys Ala Val Glu Ile Thr Thr Leu Lys Glu Leu Lys 
                245                 250                 255     


Asn Ala Leu Lys Leu Glu His His His His His His 
            260                 265             


<210>  39
<211>  269
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B. garinii (strain DK29; OspA serotype 6) aa 18-274

<400>  39

Cys Ser Ser Phe Lys Gln Asn Val Ser Ser Leu Asp Glu Lys Asn Ser 
1               5                   10                  15      


Val Ser Val Asp Leu Pro Gly Gly Met Thr Val Leu Val Ser Lys Glu 
            20                  25                  30          


Lys Asp Lys Asp Gly Lys Tyr Ser Leu Glu Ala Thr Val Asp Lys Leu 
        35                  40                  45              


Glu Leu Lys Gly Thr Ser Asp Lys Asn Asn Gly Ser Gly Thr Leu Glu 
    50                  55                  60                  


Gly Glu Lys Thr Asp Lys Ser Lys Val Lys Ser Thr Ile Ala Asp Asp 
65                  70                  75                  80  


Leu Ser Gln Thr Lys Phe Glu Ile Phe Lys Glu Asp Gly Lys Thr Leu 
                85                  90                  95      


Val Ser Lys Lys Val Thr Leu Lys Asp Lys Ser Ser Thr Glu Glu Lys 
            100                 105                 110         


Phe Asn Gly Lys Gly Glu Thr Ser Glu Lys Thr Ile Val Arg Ala Asn 
        115                 120                 125             


Gly Thr Arg Leu Glu Tyr Thr Asp Ile Lys Ser Asp Gly Ser Gly Lys 
    130                 135                 140                 


Ala Lys Glu Val Leu Lys Asp Phe Thr Leu Glu Gly Thr Leu Ala Ala 
145                 150                 155                 160 


Asp Gly Lys Thr Thr Leu Lys Val Thr Glu Gly Thr Val Val Leu Ser 
                165                 170                 175     


Lys Asn Ile Leu Lys Ser Gly Glu Ile Thr Ala Ala Leu Asp Asp Ser 
            180                 185                 190         


Asp Thr Thr Arg Ala Thr Lys Lys Thr Gly Lys Trp Asp Ser Lys Thr 
        195                 200                 205             


Ser Thr Leu Thr Ile Ser Val Asn Ser Gln Lys Thr Lys Asn Leu Val 
    210                 215                 220                 


Phe Thr Lys Glu Asp Thr Ile Thr Val Gln Arg Tyr Asp Ser Ala Gly 
225                 230                 235                 240 


Thr Asn Leu Glu Gly Lys Ala Val Glu Ile Thr Thr Leu Lys Glu Leu 
                245                 250                 255     


Lys Asn Ala Leu Lys Leu Glu His His His His His His 
            260                 265                 


<210>  40
<211>  278
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric OspA Serotype1/Serotype2, N-terminal lipidation

<400>  40

Met Arg Leu Leu Ile Gly Phe Ala Leu Ala Leu Ala Leu Ile Gly Cys 
1               5                   10                  15      


Ala Gln Lys Gly Ala Glu Ser Ile Gly Ser Val Ser Val Asp Leu Pro 
            20                  25                  30          


Gly Glu Met Lys Val Leu Val Ser Lys Glu Lys Asp Lys Asn Gly Lys 
        35                  40                  45              


Tyr Asp Leu Ile Ala Thr Val Asp Lys Leu Glu Leu Lys Gly Thr Ser 
    50                  55                  60                  


Asp Lys Asn Asn Gly Ser Gly Val Leu Glu Gly Val Lys Thr Asn Lys 
65                  70                  75                  80  


Ser Lys Val Lys Leu Thr Ile Ser Asp Asp Leu Gly Gln Thr Thr Leu 
                85                  90                  95      


Glu Val Phe Lys Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Thr 
            100                 105                 110         


Ser Lys Asp Lys Ser Ser Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu 
        115                 120                 125             


Val Ser Glu Lys Ile Ile Thr Met Ala Asp Gly Thr Arg Leu Glu Tyr 
    130                 135                 140                 


Thr Gly Ile Lys Ser Asp Gly Thr Gly Lys Ala Lys Tyr Val Leu Lys 
145                 150                 155                 160 


Asn Phe Thr Leu Glu Gly Lys Val Ala Asn Asp Lys Thr Thr Leu Glu 
                165                 170                 175     


Val Lys Glu Gly Thr Val Thr Leu Ser Met Asn Ile Ser Lys Ser Gly 
            180                 185                 190         


Glu Val Ser Val Glu Leu Asn Asp Thr Asp Ser Ser Ala Ala Thr Lys 
        195                 200                 205             


Lys Thr Ala Ala Trp Asn Ser Lys Thr Ser Thr Leu Thr Ile Ser Val 
    210                 215                 220                 


Asn Ser Lys Lys Thr Thr Gln Leu Val Phe Thr Lys Gln Asp Thr Ile 
225                 230                 235                 240 


Thr Val Gln Lys Tyr Asp Ser Ala Gly Thr Asn Leu Glu Gly Thr Ala 
                245                 250                 255     


Val Glu Ile Lys Thr Leu Asp Glu Leu Lys Asn Ala Leu Lys Leu Glu 
            260                 265                 270         


His His His His His His 
        275             


<210>  41
<211>  278
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric OspA Serotype5/Serotype3, N-terminal lipidation

<400>  41

Met Arg Leu Leu Ile Gly Phe Ala Leu Ala Leu Ala Leu Ile Gly Cys 
1               5                   10                  15      


Ala Gln Lys Gly Ala Glu Ser Ile Gly Ser Val Ser Val Asp Leu Pro 
            20                  25                  30          


Gly Gly Met Lys Val Leu Val Ser Lys Glu Lys Asp Lys Asn Gly Lys 
        35                  40                  45              


Tyr Ser Leu Met Ala Thr Val Glu Lys Leu Glu Leu Lys Gly Thr Ser 
    50                  55                  60                  


Asp Lys Asn Asn Gly Ser Gly Thr Leu Glu Gly Glu Lys Thr Asn Lys 
65                  70                  75                  80  


Ser Lys Val Lys Leu Thr Ile Ala Glu Asp Leu Ser Lys Thr Thr Phe 
                85                  90                  95      


Glu Ile Phe Lys Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Thr 
            100                 105                 110         


Leu Lys Asp Lys Ser Ser Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu 
        115                 120                 125             


Ile Ser Glu Lys Thr Ile Val Met Ala Asn Gly Thr Arg Leu Glu Tyr 
    130                 135                 140                 


Thr Asp Ile Lys Ser Asp Lys Thr Gly Lys Ala Lys Tyr Val Leu Lys 
145                 150                 155                 160 


Asp Phe Thr Leu Glu Gly Thr Leu Ala Ala Asp Gly Lys Thr Thr Leu 
                165                 170                 175     


Lys Val Thr Glu Gly Thr Val Thr Leu Ser Met Asn Ile Ser Lys Ser 
            180                 185                 190         


Gly Glu Ile Thr Val Ala Leu Asp Asp Thr Asp Ser Ser Gly Asn Lys 
        195                 200                 205             


Lys Ser Gly Thr Trp Asp Ser Asp Thr Ser Thr Leu Thr Ile Ser Lys 
    210                 215                 220                 


Asn Ser Gln Lys Thr Lys Gln Leu Val Phe Thr Lys Glu Asn Thr Ile 
225                 230                 235                 240 


Thr Val Gln Asn Tyr Asn Arg Ala Gly Asn Ala Leu Glu Gly Ser Pro 
                245                 250                 255     


Ala Glu Ile Lys Asp Leu Ala Glu Leu Lys Ala Ala Leu Lys Leu Glu 
            260                 265                 270         


His His His His His His 
        275             


<210>  42
<211>  279
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric OspA Serotype6/Serotype4, N-terminal lipidation

<400>  42

Met Arg Leu Leu Ile Gly Phe Ala Leu Ala Leu Ala Leu Ile Gly Cys 
1               5                   10                  15      


Ala Gln Lys Gly Ala Glu Ser Ile Gly Ser Val Ser Val Asp Leu Pro 
            20                  25                  30          


Gly Gly Met Thr Val Leu Val Ser Lys Glu Lys Asp Lys Asn Gly Lys 
        35                  40                  45              


Tyr Ser Leu Glu Ala Thr Val Asp Lys Leu Glu Leu Lys Gly Thr Ser 
    50                  55                  60                  


Asp Lys Asn Asn Gly Ser Gly Thr Leu Glu Gly Glu Lys Thr Asn Lys 
65                  70                  75                  80  


Ser Lys Val Lys Leu Thr Ile Ala Asp Asp Leu Ser Gln Thr Lys Phe 
                85                  90                  95      


Glu Ile Phe Lys Glu Asp Ala Lys Thr Leu Val Ser Lys Lys Val Thr 
            100                 105                 110         


Leu Lys Asp Lys Ser Ser Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu 
        115                 120                 125             


Thr Ser Glu Lys Thr Ile Val Met Ala Asn Gly Thr Arg Leu Glu Tyr 
    130                 135                 140                 


Thr Asp Ile Lys Ser Asp Gly Ser Gly Lys Ala Lys Tyr Val Leu Lys 
145                 150                 155                 160 


Asp Phe Thr Leu Glu Gly Thr Leu Ala Ala Asp Gly Lys Thr Thr Leu 
                165                 170                 175     


Lys Val Thr Glu Gly Thr Val Val Leu Ser Met Asn Ile Leu Lys Ser 
            180                 185                 190         


Gly Glu Ile Thr Val Ala Leu Asp Asp Ser Asp Thr Thr Gln Ala Thr 
        195                 200                 205             


Lys Lys Thr Gly Lys Trp Asp Ser Asn Thr Ser Thr Leu Thr Ile Ser 
    210                 215                 220                 


Val Asn Ser Lys Lys Thr Lys Asn Ile Val Phe Thr Lys Glu Asp Thr 
225                 230                 235                 240 


Ile Thr Val Gln Lys Tyr Asp Ser Ala Gly Thr Asn Leu Glu Gly Asn 
                245                 250                 255     


Ala Val Glu Ile Lys Thr Leu Asp Glu Leu Lys Asn Ala Leu Lys Leu 
            260                 265                 270         


Glu His His His His His His 
        275                 


<210>  43
<211>  148
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S1D1

<400>  43

Phe Asn Glu Lys Gly Glu Val Ser Glu Lys Ile Ile Thr Arg Ala Asp 
1               5                   10                  15      


Gly Thr Arg Leu Glu Tyr Thr Gly Ile Lys Ser Asp Gly Ser Gly Lys 
            20                  25                  30          


Ala Lys Glu Val Leu Lys Asn Phe Thr Leu Glu Gly Lys Val Ala Asn 
        35                  40                  45              


Asp Lys Thr Thr Leu Val Val Lys Cys Gly Thr Val Thr Leu Ser Lys 
    50                  55                  60                  


Asn Ile Ser Lys Ser Gly Glu Val Ser Val Glu Leu Asn Asp Thr Asp 
65                  70                  75                  80  


Ser Ser Ala Ala Thr Lys Lys Thr Ala Ala Trp Asn Ser Gly Thr Ser 
                85                  90                  95      


Thr Leu Thr Ile Thr Val Asn Ser Lys Lys Thr Lys Asp Leu Val Phe 
            100                 105                 110         


Thr Lys Glu Asn Thr Ile Thr Val Gln Gln Tyr Asp Ser Asn Gly Thr 
        115                 120                 125             


Lys Leu Glu Gly Ser Ala Val Glu Ile Thr Lys Leu Asp Glu Ile Cys 
    130                 135                 140                 


Asn Ala Leu Lys 
145             


<210>  44
<211>  148
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S2D1

<400>  44

Phe Asn Glu Lys Gly Glu Leu Ser Ala Lys Thr Met Thr Arg Glu Asn 
1               5                   10                  15      


Gly Thr Lys Leu Glu Tyr Thr Glu Met Lys Ser Asp Gly Thr Gly Lys 
            20                  25                  30          


Ala Lys Glu Val Leu Lys Asn Phe Thr Leu Glu Gly Lys Val Ala Asn 
        35                  40                  45              


Asp Lys Val Thr Leu Glu Val Lys Cys Gly Thr Val Thr Leu Ser Lys 
    50                  55                  60                  


Glu Ile Ala Lys Ser Gly Glu Val Thr Val Ala Leu Asn Asp Thr Asn 
65                  70                  75                  80  


Thr Thr Gln Ala Thr Lys Lys Thr Gly Ala Trp Asp Ser Lys Thr Ser 
                85                  90                  95      


Thr Leu Thr Ile Ser Val Asn Ser Lys Lys Thr Thr Gln Leu Val Phe 
            100                 105                 110         


Thr Lys Gln Asp Thr Ile Thr Val Gln Lys Tyr Asp Ser Ala Gly Thr 
        115                 120                 125             


Asn Leu Glu Gly Thr Ala Val Glu Ile Lys Thr Leu Asp Glu Leu Cys 
    130                 135                 140                 


Asn Ala Leu Lys 
145             


<210>  45
<211>  149
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S3D1

<400>  45

Phe Asn Asp Lys Gly Lys Leu Ser Glu Lys Val Val Thr Arg Ala Asn 
1               5                   10                  15      


Gly Thr Arg Leu Glu Tyr Thr Glu Ile Lys Asn Asp Gly Ser Gly Lys 
            20                  25                  30          


Ala Lys Glu Val Leu Lys Gly Phe Ala Leu Glu Gly Thr Leu Thr Asp 
        35                  40                  45              


Gly Gly Glu Thr Lys Leu Thr Val Thr Cys Gly Thr Val Thr Leu Ser 
    50                  55                  60                  


Lys Asn Ile Ser Lys Ser Gly Glu Ile Thr Val Ala Leu Asn Asp Thr 
65                  70                  75                  80  


Glu Thr Thr Pro Ala Asp Lys Lys Thr Gly Glu Trp Lys Ser Asp Thr 
                85                  90                  95      


Ser Thr Leu Thr Ile Ser Lys Asn Ser Gln Lys Thr Lys Gln Leu Val 
            100                 105                 110         


Phe Thr Lys Glu Asn Thr Ile Thr Val Gln Asn Tyr Asn Arg Ala Gly 
        115                 120                 125             


Asn Ala Leu Glu Gly Ser Pro Ala Glu Ile Lys Asp Leu Ala Glu Leu 
    130                 135                 140                 


Cys Ala Ala Leu Lys 
145                 


<210>  46
<211>  148
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S4D1

<400>  46

Phe Asn Ala Lys Gly Glu Leu Ser Glu Lys Thr Ile Leu Arg Ala Asn 
1               5                   10                  15      


Gly Thr Arg Leu Glu Tyr Thr Glu Ile Lys Ser Asp Gly Thr Gly Lys 
            20                  25                  30          


Ala Lys Glu Val Leu Lys Asp Phe Ala Leu Glu Gly Thr Leu Ala Ala 
        35                  40                  45              


Asp Lys Thr Thr Leu Lys Val Thr Cys Gly Thr Val Val Leu Ser Lys 
    50                  55                  60                  


His Ile Pro Asn Ser Gly Glu Ile Thr Val Glu Leu Asn Asp Ser Asn 
65                  70                  75                  80  


Ser Thr Gln Ala Thr Lys Lys Thr Gly Lys Trp Asp Ser Asn Thr Ser 
                85                  90                  95      


Thr Leu Thr Ile Ser Val Asn Ser Lys Lys Thr Lys Asn Ile Val Phe 
            100                 105                 110         


Thr Lys Glu Asp Thr Ile Thr Val Gln Lys Tyr Asp Ser Ala Gly Thr 
        115                 120                 125             


Asn Leu Glu Gly Asn Ala Val Glu Ile Lys Thr Leu Asp Glu Leu Cys 
    130                 135                 140                 


Asn Ala Leu Lys 
145             


<210>  47
<211>  148
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S5D1

<400>  47

Phe Asn Glu Lys Gly Glu Ile Ser Glu Lys Thr Ile Val Arg Ala Asn 
1               5                   10                  15      


Gly Thr Arg Leu Glu Tyr Thr Asp Ile Lys Ser Asp Lys Thr Gly Lys 
            20                  25                  30          


Ala Lys Glu Val Leu Lys Asp Phe Thr Leu Glu Gly Thr Leu Ala Ala 
        35                  40                  45              


Asp Gly Lys Thr Thr Leu Lys Val Thr Cys Gly Thr Val Thr Leu Ser 
    50                  55                  60                  


Lys Asn Ile Ser Lys Ser Gly Glu Ile Thr Val Ala Leu Asp Asp Thr 
65                  70                  75                  80  


Asp Ser Ser Gly Asn Lys Lys Ser Gly Thr Trp Asp Ser Gly Thr Ser 
                85                  90                  95      


Thr Leu Thr Ile Ser Lys Asn Arg Thr Lys Thr Lys Gln Leu Val Phe 
            100                 105                 110         


Thr Lys Glu Asp Thr Ile Thr Val Gln Asn Tyr Asp Ser Ala Gly Thr 
        115                 120                 125             


Asn Leu Glu Gly Lys Ala Val Glu Ile Thr Thr Leu Lys Glu Leu Cys 
    130                 135                 140                 


Asn Ala Leu Lys 
145             


<210>  48
<211>  149
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S6D1

<400>  48

Phe Asn Gly Lys Gly Glu Thr Ser Glu Lys Thr Ile Val Arg Ala Asn 
1               5                   10                  15      


Gly Thr Arg Leu Glu Tyr Thr Asp Ile Lys Ser Asp Gly Ser Gly Lys 
            20                  25                  30          


Ala Lys Glu Val Leu Lys Asp Phe Thr Leu Glu Gly Thr Leu Ala Ala 
        35                  40                  45              


Asp Gly Lys Thr Thr Leu Lys Val Thr Cys Gly Thr Val Val Leu Ser 
    50                  55                  60                  


Lys Asn Ile Leu Lys Ser Gly Glu Ile Thr Ala Ala Leu Asp Asp Ser 
65                  70                  75                  80  


Asp Thr Thr Arg Ala Thr Lys Lys Thr Gly Lys Trp Asp Ser Lys Thr 
                85                  90                  95      


Ser Thr Leu Thr Ile Ser Val Asn Ser Gln Lys Thr Lys Asn Leu Val 
            100                 105                 110         


Phe Thr Lys Glu Asp Thr Ile Thr Val Gln Arg Tyr Asp Ser Ala Gly 
        115                 120                 125             


Thr Asn Leu Glu Gly Lys Ala Val Glu Ile Thr Thr Leu Lys Glu Leu 
    130                 135                 140                 


Cys Asn Ala Leu Lys 
145                 


<210>  49
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S3HYBD1 (BVA)

<400>  49

Phe Asn Glu Lys Gly Glu Val Ser Glu Lys Ile Leu Thr Arg Ser Asn 
1               5                   10                  15      


Gly Thr Thr Leu Glu Tyr Ser Gln Met Thr Asp Ala Glu Asn Ala Thr 
            20                  25                  30          


Lys Ala Val Glu Thr Leu Lys Asn Gly Ile Lys Leu Pro Gly Asn Leu 
        35                  40                  45              


Val Gly Gly Lys Thr Lys Leu Thr Val Thr Cys Gly Thr Val Thr Leu 
    50                  55                  60                  


Ser Lys Asn Ile Ser Lys Ser Gly Glu Ile Thr Val Ala Leu Asn Asp 
65                  70                  75                  80  


Thr Glu Thr Thr Pro Ala Asp Lys Lys Thr Gly Glu Trp Lys Ser Asp 
                85                  90                  95      


Thr Ser Thr Leu Thr Ile Ser Lys Asn Ser Gln Lys Thr Lys Gln Leu 
            100                 105                 110         


Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln Asn Tyr Asn Arg Ala 
        115                 120                 125             


Gly Asn Ala Leu Glu Gly Ser Pro Ala Glu Ile Lys Asp Leu Ala Glu 
    130                 135                 140                 


Leu Cys Ala Ala Leu Lys 
145                 150 


<210>  50
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BVAD1

<400>  50

Phe Asn Glu Lys Gly Glu Val Ser Glu Lys Ile Leu Thr Arg Ser Asn 
1               5                   10                  15      


Gly Thr Thr Leu Glu Tyr Ser Gln Met Thr Asp Ala Glu Asn Ala Thr 
            20                  25                  30          


Lys Ala Val Glu Thr Leu Lys Asn Gly Ile Lys Leu Pro Gly Asn Leu 
        35                  40                  45              


Val Gly Gly Lys Thr Thr Leu Lys Ile Thr Cys Gly Thr Val Thr Leu 
    50                  55                  60                  


Ser Lys His Ile Ala Lys Ser Gly Glu Val Thr Val Glu Ile Asn Asp 
65                  70                  75                  80  


Thr Ser Ser Thr Pro Asn Thr Lys Lys Thr Gly Lys Trp Asp Ala Arg 
                85                  90                  95      


Asn Ser Thr Leu Thr Ile Ile Val Asp Ser Lys Asn Lys Thr Lys Leu 
            100                 105                 110         


Val Phe Thr Lys Gln Asp Thr Ile Thr Val Gln Ser Tyr Asn Pro Ala 
        115                 120                 125             


Gly Asn Lys Leu Glu Gly Thr Ala Val Glu Ile Lys Thr Leu Gln Glu 
    130                 135                 140                 


Leu Cys Asn Ala Leu Lys 
145                 150 


<210>  51
<211>  148
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S3HYBD1 (BSP)

<400>  51

Phe Asn Glu Lys Gly Glu Leu Ser Glu Lys Thr Leu Val Arg Ala Asn 
1               5                   10                  15      


Gly Thr Lys Leu Glu Tyr Thr Glu Ile Lys Ser Asp Gly Thr Gly Lys 
            20                  25                  30          


Ala Lys Glu Val Leu Lys Asp Phe Thr Leu Glu Gly Thr Leu Ala Asn 
        35                  40                  45              


Glu Lys Thr Lys Leu Thr Val Thr Cys Gly Thr Val Thr Leu Ser Lys 
    50                  55                  60                  


Asn Ile Ser Lys Ser Gly Glu Ile Thr Val Ala Leu Asn Asp Thr Glu 
65                  70                  75                  80  


Thr Thr Pro Ala Asp Lys Lys Thr Gly Glu Trp Lys Ser Asp Thr Ser 
                85                  90                  95      


Thr Leu Thr Ile Ser Lys Asn Ser Gln Lys Thr Lys Gln Leu Val Phe 
            100                 105                 110         


Thr Lys Glu Asn Thr Ile Thr Val Gln Asn Tyr Asn Arg Ala Gly Asn 
        115                 120                 125             


Ala Leu Glu Gly Ser Pro Ala Glu Ile Lys Asp Leu Ala Glu Leu Cys 
    130                 135                 140                 


Ala Ala Leu Lys 
145             


<210>  52
<211>  148
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MSPD1

<400>  52

Phe Asn Glu Lys Gly Glu Leu Ser Glu Lys Thr Leu Val Arg Ala Asn 
1               5                   10                  15      


Gly Thr Lys Leu Glu Tyr Thr Glu Ile Lys Ser Asp Gly Thr Gly Lys 
            20                  25                  30          


Ala Lys Glu Val Leu Lys Asp Phe Thr Leu Glu Gly Thr Leu Ala Asn 
        35                  40                  45              


Glu Lys Ala Thr Leu Thr Val Lys Cys Gly Thr Val Thr Leu Ser Lys 
    50                  55                  60                  


Asn Ile Asp Lys Ser Gly Glu Val Thr Val Ala Leu Asn Asp Thr Asp 
65                  70                  75                  80  


Ser Thr Ala Ala Thr Lys Lys Thr Gly Ala Trp Asp Ser Lys Thr Ser 
                85                  90                  95      


Thr Leu Thr Ile Thr Val Asn Ser Lys Lys Thr Lys Asp Leu Val Phe 
            100                 105                 110         


Thr Lys Gln Asp Thr Ile Thr Val Gln Lys Tyr Asp Ser Ala Gly Thr 
        115                 120                 125             


Thr Leu Glu Gly Ser Ala Val Glu Ile Lys Thr Leu Asp Glu Leu Cys 
    130                 135                 140                 


Asn Ala Leu Lys 
145             


<210>  53
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer for the 16S-23S intergenic spacer

<400>  53
gtatgtttag tgaggggggt g                                                 21


<210>  54
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer for the 16S-23S intergenic spacer

<400>  54
ggatcatagc tcaggtggtt ag                                                22


<210>  55
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward nested primer for the 16S-23S intergenic spacer

<400>  55
aggggggtga agtcgtaaca ag                                                22


<210>  56
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse nested primer for the 16S-23S intergenic spacer

<400>  56
gtctgataaa cctgaggtcg ga                                                22


<210>  57
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer for the RecA gene of Borrelia

<400>  57
catgctcttg atcctgttta                                                   20


<210>  58
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer for the RecA gene of Borrelia

<400>  58
cccatttctc catctatctc                                                   20


<210>  59
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  25-mer peptide from the Invariable Region 6 (IR6) of VlsE

<400>  59

Met Lys Lys Asp Asp Gln Ile Ala Ala Ala Met Val Leu Arg Gly Met 
1               5                   10                  15      


Ala Lys Asp Gly Gln Phe Ala Leu Lys 
            20                  25  


<210>  60
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse cathelin

<400>  60

Arg Leu Ala Gly Leu Leu Arg Lys Gly Gly Glu Lys Ile Gly Glu Lys 
1               5                   10                  15      


Leu Lys Lys Ile Gly Gln Lys Ile Lys Asn Phe Phe Gln Lys Leu Val 
            20                  25                  30          


Pro Gln Pro Glu 
        35      


<210>  61
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLK peptide

<400>  61

Lys Leu Lys Leu Leu Leu Leu Leu Lys Leu Lys 
1               5                   10      


<210>  62
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal peptide for lipidation

<400>  62

Cys Lys Gln Asn 
1               


<210>  63
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5'-(dIdC)13-3'


<220>
<221>  misc_feature
<222>  (1)..(26)
<223>  n=inosine

<400>  63
ncncncncnc ncncncncnc ncncnc                                            26


