                         SEQUENCE LISTING

<110>  Johns Hopkins Technology Transfer
 
<120>  ANTIMICROBIAL COMPOSITIONS COMPRISING SINGLE DOMAIN ANTIBODIES 
       AND PSEUDOMONAS EXOTOXIN

<130>  P12627-01

<150>  61/922,927
<151>  2014-01-02

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  471
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  1
atggcacatc accaccacca tcactccgcg gctcttgaag tcctctttca gggacccggg       60

taccaggatc cgaattctat ggccgaggtg cagctgcagg cgtctggggg aggattggtg      120

caggctgggg gctctctgag actctcctgt gcagcctctg gacgcgccac cggtaactat      180

cccatgggct ggttccgcca ggctccaggg aaggagcgtg agtttgtagc cgctattagc      240

cgggatggag atagcacata ctacagagac tccgtgaagg gccgattcac catctccaga      300

gacaacgcca agaacacggt gtatctgcaa atgaacagcc tgaaacctga ggacacggcc      360

gtttattact gtgcagcaga ccgacttaca gcctatcgct acaatccagg gcagattgac      420

tactggggcc aggggaccca ggtcaccgtc tcctcactcg aggcggccgc c               471


<210>  2
<211>  1513
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  2
atggcacatc accaccacca tcactccgcg gctcttgaag tcctctttca gggacccggg       60

taccaggatc cgaattctat ggccgaggtg cagctgcagg cgtctggggg aggattggtg      120

caggctgggg gctctctgag actctcctgt gcagcctctg gacgcgccac cggtaactat      180

cccatgggct ggttccgcca ggctccaggg aaggagcgtg agtttgtagc cgctattagc      240

cgggatggag atagcacata ctacagagac tccgtgaagg gccgattcac catctccaga      300

gacaacgcca agaacacggt gtatctgcaa atgaacagcc tgaaacctga ggacacggcc      360

gtttattact gtgcagcaga ccgacttaca gcctatcgct acaatccagg gcagattgac      420

tactggggcc aggggaccca ggtcaccgtc tcctcactcg aggcggccgc ccccgagggc      480

ggcagcctgg ccgcgctgac cgcgcaccag gcttgccacc tgccgctgga gactttcacc      540

cgtcatcgcc agccgcgcgg ctgggaacaa ctggagcagt gcggctatcc ggtgcagcgg      600

ctggtcgccc tctacctggc ggcgcggctg tcgtggaacc aggtcgacca ggtgatccgc      660

aacgccctgg ccagccccgg cagcggcggc gacctgggcg aagcgatccg cgagcagccg      720

gagcaggccc gtctggccct gaccctggcc gccgccgaga gcgagcgctt cgtccggcag      780

ggcaccggca acgacgaggc cggcgcggcc aacggcccgg cggacagcgg cgacgccctg      840

ctggagcgca actatcccac tggcgcggag ttcctcggcg acggcggcga cgtcagcttc      900

agcacccgag gcacgcagaa ctggacggtg gagcggctgc tccaggcgca cgcccaactg      960

gaggagcgcg gctatgtgtt cgtcggctac cacggcacct tcctcgaagc ggcgcaaagc     1020

atcgtcttcg gcggggtgcg cgcggccagc caggacctcg ccgcgatctg ggccggtttc     1080

tatatcgccg gcgatccggc gctggcctac ggctacgccc aggaccagga acccgacgca     1140

gccggccgaa tccgcaacgg tgccctgctg cgggtctatg tgccggcatc gagcctgccg     1200

ggcttctacc gcaccagcct gaccctggcc gcgccggagg cggcgggcga ggtcgaacgg     1260

ctgatcggcc atccgctgcc gctggccctg gacgccatca ccggccccga ggaggaaggc     1320

gggcgcctgg agaccattct cggctggccg ctggccgagc gcaccgtggt gattccctcg     1380

gcgatcccca ccgacccgcg caacgtcggc ggcgacctcg acccgtccag catccccgac     1440

aaggaacagg cgcagcgccc tgccggacta cgccagccag cccggcaaac cgccgcgcga     1500

ggacctgaag taa                                                        1513


<210>  3
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  3

Met Ala His His His His His His Ser Ala Ala Leu Glu Val Leu Phe 
1               5                   10                  15      


Gln Gly Pro Gly Tyr Gln Asp Pro Asn Ser Met Ala Glu Val Gln Leu 
            20                  25                  30          


Gln Ala Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu 
        35                  40                  45              


Ser Cys Ala Ala Ser Gly Arg Ala Thr Gly Asn Tyr Pro Met Gly Trp 
    50                  55                  60                  


Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser 
65                  70                  75                  80  


Arg Asp Gly Asp Ser Thr Tyr Tyr Arg Asp Ser Val Lys Gly Arg Phe 
                85                  90                  95      


Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn 
            100                 105                 110         


Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Asp Arg 
        115                 120                 125             


Leu Thr Ala Tyr Arg Tyr Asn Pro Gly Gln Ile Asp Tyr Trp Gly Gln 
    130                 135                 140                 


Gly Thr Gln Val Thr Val Ser Ser Leu Glu Ala Ala Ala 
145                 150                 155         


<210>  4
<211>  504
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  4

Met Ala His His His His His His Ser Ala Ala Leu Glu Val Leu Phe 
1               5                   10                  15      


Gln Gly Pro Gly Tyr Gln Asp Pro Asn Ser Met Ala Glu Val Gln Leu 
            20                  25                  30          


Gln Ala Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu 
        35                  40                  45              


Ser Cys Ala Ala Ser Gly Arg Ala Thr Gly Asn Tyr Pro Met Gly Trp 
    50                  55                  60                  


Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser 
65                  70                  75                  80  


Arg Asp Gly Asp Ser Thr Tyr Tyr Arg Asp Ser Val Lys Gly Arg Phe 
                85                  90                  95      


Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn 
            100                 105                 110         


Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Asp Arg 
        115                 120                 125             


Leu Thr Ala Tyr Arg Tyr Asn Pro Gly Gln Ile Asp Tyr Trp Gly Gln 
    130                 135                 140                 


Gly Thr Gln Val Thr Val Ser Ser Leu Glu Ala Ala Ala Pro Glu Gly 
145                 150                 155                 160 


Gly Ser Leu Ala Ala Leu Thr Ala His Gln Ala Cys His Leu Pro Leu 
                165                 170                 175     


Glu Thr Phe Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu Glu 
            180                 185                 190         


Gln Cys Gly Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu Ala Ala 
        195                 200                 205             


Arg Leu Ser Trp Asn Gln Val Asp Gln Val Ile Arg Asn Ala Leu Ala 
    210                 215                 220                 


Ser Pro Gly Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg Glu Gln Pro 
225                 230                 235                 240 


Glu Gln Ala Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu Ser Glu Arg 
                245                 250                 255     


Phe Val Arg Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala Ala Asn Gly 
            260                 265                 270         


Pro Ala Asp Ser Gly Asp Ala Leu Leu Glu Arg Asn Tyr Pro Thr Gly 
        275                 280                 285             


Ala Glu Phe Leu Gly Asp Gly Gly Asp Val Ser Phe Ser Thr Arg Gly 
    290                 295                 300                 


Thr Gln Asn Trp Thr Val Glu Arg Leu Leu Gln Ala His Ala Gln Leu 
305                 310                 315                 320 


Glu Glu Arg Gly Tyr Val Phe Val Gly Tyr His Gly Thr Phe Leu Glu 
                325                 330                 335     


Ala Ala Gln Ser Ile Val Phe Gly Gly Val Arg Ala Ala Ser Gln Asp 
            340                 345                 350         


Leu Ala Ala Ile Trp Ala Gly Phe Tyr Ile Ala Gly Asp Pro Ala Leu 
        355                 360                 365             


Ala Tyr Gly Tyr Ala Gln Asp Gln Glu Pro Asp Ala Ala Gly Arg Ile 
    370                 375                 380                 


Arg Asn Gly Ala Leu Leu Arg Val Tyr Val Pro Ala Ser Ser Leu Pro 
385                 390                 395                 400 


Gly Phe Tyr Arg Thr Ser Leu Thr Leu Ala Ala Pro Glu Ala Ala Gly 
                405                 410                 415     


Glu Val Glu Arg Leu Ile Gly His Pro Leu Pro Leu Ala Leu Asp Ala 
            420                 425                 430         


Ile Thr Gly Pro Glu Glu Glu Gly Gly Arg Leu Glu Thr Ile Leu Gly 
        435                 440                 445             


Trp Pro Leu Ala Glu Arg Thr Val Val Ile Pro Ser Ala Ile Pro Thr 
    450                 455                 460                 


Asp Pro Arg Asn Val Gly Gly Asp Leu Asp Pro Ser Ser Ile Pro Asp 
465                 470                 475                 480 


Lys Glu Gln Ala Ile Ser Ala Leu Pro Asp Tyr Ala Ser Gln Pro Gly 
                485                 490                 495     


Lys Pro Pro Arg Glu Asp Leu Lys 
            500                 


<210>  5
<211>  446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  5
gaattccgaa gtgcagctgg tggaaagcgg cggcggcctg gtgcaggcgg gcggctttct       60

gcgcctgagc tgcgaactgc gcggcagcat ttttaaccag tatgcgatgg gctggtttcg      120

ccaggcgccg ggcaaagaac gcgaatttgt ggcgggcatg ggcgcggtgc cgcattatgg      180

cgaatttgtg aaaggccgct ttaccattag ccgcgataac gcgaaaagca ccgtgtatct      240

gcagatgagc agcctgaaac cggaagatac cgcgatttat ttttgcgcgc gcagcaaaag      300

cacctatatt agctataaca gcaacggcta tgattattgg ggccgcggca cccaggtgac      360

cgtgagcagc ctgcaggacg tcactagtcc atggcatatg gaacagaaac tgatctcaga      420

agaggatctg ctcgaggcgg ccgccc                                           446


<210>  6
<211>  1495
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  6
gaattccgaa gtgcagctgg tggaaagcgg cggcggcctg gtgcaggcgg gcggctttct       60

gcgcctgagc tgcgaactgc gcggcagcat ttttaaccag tatgcgatgg gctggtttcg      120

ccaggcgccg ggcaaagaac gcgaatttgt ggcgggcatg ggcgcggtgc cgcattatgg      180

cgaatttgtg aaaggccgct ttaccattag ccgcgataac gcgaaaagca ccgtgtatct      240

gcagatgagc agcctgaaac cggaagatac cgcgatttat ttttgcgcgc gcagcaaaag      300

cacctatatt agctataaca gcaacggcta tgattattgg ggccgcggca cccaggtgac      360

cgtgagcagc ctgcaggacg tcactagtcc atggcatatg gaacagaaac tgatctcaga      420

agaggatctg ctcgaggcgg ccgccccgga aggtggcagc ctggcagcac tgaccgctca      480

tcaggcatgc cacctgccgc tggaaacctt tacgcgtcat cgtcagccgc gtggctggga      540

acagctggaa caatgtggtt atccggtcca gcgtctggtg gccctgtacc tggcagctcg      600

cctgagctgg aaccaggtgg atcaagttat tcgtaatgca ctggcaagcc cgggttctgg      660

cggtgacctg ggtgaagcga tccgtgaaca gccggaacaa gcacgtctgg cactgaccct      720

ggcagcagca gaaagcgaac gtttcgtgcg ccagggcacg ggtaacgatg aagccggcgc      780

tgcgaatggt ccggctgatt ctggcgacgc gctgctggaa cgtaactatc cgaccggcgc      840

agaatttctg ggtgatggcg gtgacgtgtc attctcgacc cgtggcacgc agaattggac      900

ggttgaacgc ctgctgcagg ctcatgcgca actggaagaa cgtggttatg tctttgtggg      960

ctaccacggc accttcctgg aagccgcaca gtcaattgtt tttggcggtg tccgcgctgc     1020

gtcgcaagat ctggccgcaa tttgggccgg cttctacatc gcaggtgacc cggccctggc     1080

atatggctac gcgcaggatc aagaaccgga cgctgcaggt cgtatccgta acggtgctct     1140

gctgcgtgtt tatgtcccgg ccagctctct gccgggtttt taccgtacct cactgacgct     1200

ggcagcaccg gaagctgcag gcgaagtcga acgtctgatt ggtcacccgc tgccgctggc     1260

tctggatgca atcaccggtc cggaagaaga aggcggccgt ctggaaacga ttctgggttg     1320

gccgctggca gaacgcaccg tggttattcc gtccgcgatc ccgaccgacc cgcgcaatgt     1380

tggcggtgat ctggacccga gttccattcc ggataaagaa caggccatca gtgcactgcc     1440

ggactatgcg tcccaaccgg gtaaaccgcc gcgtgaagat ctgaaataac ctagg          1495


<210>  7
<211>  149
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  7

Pro Asn Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
1               5                   10                  15      


Ala Gly Gly Phe Leu Arg Leu Ser Cys Glu Leu Arg Gly Ser Ile Phe 
            20                  25                  30          


Asn Gln Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
        35                  40                  45              


Glu Phe Val Ala Gly Met Gly Ala Val Pro His Tyr Gly Glu Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Lys Ser Thr Tyr Ile Ser Tyr Asn Ser Asn Gly Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Arg Gly Thr Gln Val Thr Val Ser Ser Leu Gln Asp Val 
        115                 120                 125             


Thr Ser Pro Trp His Met Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
    130                 135                 140                 


Leu Glu Ala Ala Ala 
145                 


<210>  8
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  8

Pro Asn Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
1               5                   10                  15      


Ala Gly Gly Phe Leu Arg Leu Ser Cys Glu Leu Arg Gly Ser Ile Phe 
            20                  25                  30          


Asn Gln Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
        35                  40                  45              


Glu Phe Val Ala Gly Met Gly Ala Val Pro His Tyr Gly Glu Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Lys Ser Thr Tyr Ile Ser Tyr Asn Ser Asn Gly Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Arg Gly Thr Gln Val Thr Val Ser Ser Leu Gln Asp Val 
        115                 120                 125             


Thr Ser Pro Trp His Met Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
    130                 135                 140                 


Leu Glu Ala Ala Ala Pro Glu Gly Gly Ser Leu Ala Ala Leu Thr Ala 
145                 150                 155                 160 


His Gln Ala Cys His Leu Pro Leu Glu Thr Phe Thr Arg His Arg Gln 
                165                 170                 175     


Pro Arg Gly Trp Glu Gln Leu Glu Gln Cys Gly Tyr Pro Val Gln Arg 
            180                 185                 190         


Leu Val Ala Leu Tyr Leu Ala Ala Arg Leu Ser Trp Asn Gln Val Asp 
        195                 200                 205             


Gln Val Ile Arg Asn Ala Leu Ala Ser Pro Gly Ser Gly Gly Asp Leu 
    210                 215                 220                 


Gly Glu Ala Ile Arg Glu Gln Pro Glu Gln Ala Arg Leu Ala Leu Thr 
225                 230                 235                 240 


Leu Ala Ala Ala Glu Ser Glu Arg Phe Val Arg Gln Gly Thr Gly Asn 
                245                 250                 255     


Asp Glu Ala Gly Ala Ala Asn Gly Pro Ala Asp Ser Gly Asp Ala Leu 
            260                 265                 270         


Leu Glu Arg Asn Tyr Pro Thr Gly Ala Glu Phe Leu Gly Asp Gly Gly 
        275                 280                 285             


Asp Val Ser Phe Ser Thr Arg Gly Thr Gln Asn Trp Thr Val Glu Arg 
    290                 295                 300                 


Leu Leu Gln Ala His Ala Gln Leu Glu Glu Arg Gly Tyr Val Phe Val 
305                 310                 315                 320 


Gly Tyr His Gly Thr Phe Leu Glu Ala Ala Gln Ser Ile Val Phe Gly 
                325                 330                 335     


Gly Val Arg Ala Ala Ser Gln Asp Leu Ala Ala Ile Trp Ala Gly Phe 
            340                 345                 350         


Tyr Ile Ala Gly Asp Pro Ala Leu Ala Tyr Gly Tyr Ala Gln Asp Gln 
        355                 360                 365             


Glu Pro Asp Ala Ala Gly Arg Ile Arg Asn Gly Ala Leu Leu Arg Val 
    370                 375                 380                 


Tyr Val Pro Ala Ser Ser Leu Pro Gly Phe Tyr Arg Thr Ser Leu Thr 
385                 390                 395                 400 


Leu Ala Ala Pro Glu Ala Ala Gly Glu Val Glu Arg Leu Ile Gly His 
                405                 410                 415     


Pro Leu Pro Leu Ala Leu Asp Ala Ile Thr Gly Pro Glu Glu Glu Gly 
            420                 425                 430         


Gly Arg Leu Glu Thr Ile Leu Gly Trp Pro Leu Ala Glu Arg Thr Val 
        435                 440                 445             


Val Ile Pro Ser Ala Ile Pro Thr Asp Pro Arg Asn Val Gly Gly Asp 
    450                 455                 460                 


Leu Asp Pro Ser Ser Ile Pro Asp Lys Glu Gln Ala Ile Ser Ala Leu 
465                 470                 475                 480 


Pro Asp Tyr Ala Ser Gln Pro Gly Lys Pro Pro Arg Glu Asp Leu Lys 
                485                 490                 495     


Pro Arg 
        


<210>  9
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  9
cccgaattca ccatgaaata cgccttagca gacccctcg                              39


<210>  10
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  10
attgcggccg cgttaatggt gatggtgatg gtgcgggttg ctgggggc                    48


<210>  11
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  11

Met Ala His His His His His His Ser Ala Ala Leu Glu Val Leu Phe 
1               5                   10                  15      


Gln Gly Pro Gly Tyr Gln Asp Pro Asn Ser Glu Val Gln Leu Val Glu 
            20                  25                  30          


Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Phe Leu Arg Leu Ser Cys 
        35                  40                  45              


Glu Leu Arg Gly Ser Ile Phe Asn Gln Tyr Ala Met Gly Trp Phe Arg 
    50                  55                  60                  


Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Gly Met Gly Ala Val 
65                  70                  75                  80  


Pro His Tyr Gly Glu Phe Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
                85                  90                  95      


Asn Ala Lys Ser Thr Val Tyr Leu Gln Met Ser Ser Leu Lys Pro Glu 
            100                 105                 110         


Asp Thr Ala Ile Tyr Phe Cys Ala Arg Ser Lys Ser Thr Tyr Ile Ser 
        115                 120                 125             


Tyr Asn Ser Asn Gly Tyr Asp Tyr Trp Gly Arg Gly Thr Gln Val Thr 
    130                 135                 140                 


Val Ser Ser 
145         


<210>  12
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  12

Met Ala His His His His His His Ser Ala Ala Leu Glu Val Leu Phe 
1               5                   10                  15      


Gln Gly Pro Gly Tyr Gln Asp Pro Asn Ser Glu Val Gln Leu Val Glu 
            20                  25                  30          


Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Phe Leu Arg Leu Ser Cys 
        35                  40                  45              


Glu Leu Arg Gly Ser Ile Phe Asn Gln Tyr Ala Met Gly Trp Phe Arg 
    50                  55                  60                  


Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Gly Met Gly Ala Val 
65                  70                  75                  80  


Pro His Tyr Gly Glu Phe Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
                85                  90                  95      


Asn Ala Lys Ser Thr Val Tyr Leu Gln Met Ser Ser Leu Lys Pro Glu 
            100                 105                 110         


Asp Thr Ala Ile Tyr Phe Cys Ala Arg Ser Lys Ser Thr Tyr Ile Ser 
        115                 120                 125             


Tyr Asn Ser Asn Gly Tyr Asp Tyr Trp Gly Arg Gly Thr Gln Val Thr 
    130                 135                 140                 


Val Ser Ser Leu Gln Asp Val Thr Ser Pro Trp His Met Glu Gln Lys 
145                 150                 155                 160 


Leu Ile Ser Glu Glu Asp Leu Leu Glu Ala Ala Ala Pro Glu Gly Gly 
                165                 170                 175     


Ser Leu Ala Ala Leu Thr Ala His Gln Ala Cys His Leu Pro Leu Glu 
            180                 185                 190         


Thr Phe Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu Glu Gln 
        195                 200                 205             


Cys Gly Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu Ala Ala Arg 
    210                 215                 220                 


Leu Ser Trp Asn Gln Val Asp Gln Val Ile Arg Asn Ala Leu Ala Ser 
225                 230                 235                 240 


Pro Gly Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg Glu Gln Pro Glu 
                245                 250                 255     


Gln Ala Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu Ser Glu Arg Phe 
            260                 265                 270         


Val Arg Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala Ala Asn Gly Pro 
        275                 280                 285             


Ala Asp Ser Gly Asp Ala Leu Leu Glu Arg Asn Tyr Pro Thr Gly Ala 
    290                 295                 300                 


Glu Phe Leu Gly Asp Gly Gly Asp Val Ser Phe Ser Thr Arg Gly Thr 
305                 310                 315                 320 


Gln Asn Trp Thr Val Glu Arg Leu Leu Gln Ala His Ala Gln Leu Glu 
                325                 330                 335     


Glu Arg Gly Tyr Val Phe Val Gly Tyr His Gly Thr Phe Leu Glu Ala 
            340                 345                 350         


Ala Gln Ser Ile Val Phe Gly Gly Val Arg Ala Ala Ser Gln Asp Leu 
        355                 360                 365             


Ala Ala Ile Trp Ala Gly Phe Tyr Ile Ala Gly Asp Pro Ala Leu Ala 
    370                 375                 380                 


Tyr Gly Tyr Ala Gln Asp Gln Glu Pro Asp Ala Ala Gly Arg Ile Arg 
385                 390                 395                 400 


Asn Gly Ala Leu Leu Arg Val Tyr Val Pro Ala Ser Ser Leu Pro Gly 
                405                 410                 415     


Phe Tyr Arg Thr Ser Leu Thr Leu Ala Ala Pro Glu Ala Ala Gly Glu 
            420                 425                 430         


Val Glu Arg Leu Ile Gly His Pro Leu Pro Leu Ala Leu Asp Ala Ile 
        435                 440                 445             


Thr Gly Pro Glu Glu Glu Gly Gly Arg Leu Glu Thr Ile Leu Gly Trp 
    450                 455                 460                 


Pro Leu Ala Glu Arg Thr Val Val Ile Pro Ser Ala Ile Pro Thr Asp 
465                 470                 475                 480 


Pro Arg Asn Val Gly Gly Asp Leu Asp Pro Ser Ser Ile Pro Asp Lys 
                485                 490                 495     


Glu Gln Ala Ile Ser Ala Leu Pro Asp Tyr Ala Ser Gln Pro Gly Lys 
            500                 505                 510         


Pro Pro Arg Glu Asp Leu Lys Pro Arg 
        515                 520     


<210>  13
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  13

Gly Gly Gly Ser 
1               


<210>  14
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  14

Arg Leu Met Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Glu 
1               5                   10                  15      


Asp Asp Phe 
            


