                               SEQUENCE LISTING

<110> THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF 
      MILITARY MEDICINE, INC.
      GENOMATIX
 
<120> PROSTATE CANCER GENE PROFILES AND METHODS OF USING THE SAME

<130> HMJ-145-PCT

<140>
<141>

<150> 61/921,739
<151> 2013-12-30

<160> 57    

<170> PatentIn version 3.5

<210> 1
<211> 255
<212> PRT
<213> Homo sapiens

<400> 1
Met Thr Met Thr Thr Met Pro Glu Ser Leu Asn Ser Pro Val Ser Gly 
1               5                   10                  15      


Lys Ala Val Phe Met Glu Phe Gly Pro Pro Asn Gln Gln Met Ser Pro 
            20                  25                  30          


Ser Pro Met Ser His Gly His Tyr Ser Met His Cys Leu His Ser Ala 
        35                  40                  45              


Gly His Ser Gln Pro Asp Gly Ala Tyr Ser Ser Ala Ser Ser Phe Ser 
    50                  55                  60                  


Arg Pro Leu Gly Tyr Pro Tyr Val Asn Ser Val Ser Ser His Ala Ser 
65                  70                  75                  80  


Ser Pro Tyr Ile Ser Ser Val Gln Ser Tyr Pro Gly Ser Ala Ser Leu 
                85                  90                  95      


Ala Gln Ser Arg Leu Glu Asp Pro Gly Ala Asp Ser Glu Lys Ser Thr 
            100                 105                 110         


Val Val Glu Gly Gly Glu Val Arg Phe Asn Gly Lys Gly Lys Lys Ile 
        115                 120                 125             


Arg Lys Pro Arg Thr Ile Tyr Ser Ser Leu Gln Leu Gln Ala Leu Asn 
    130                 135                 140                 


Arg Arg Phe Gln Gln Thr Gln Tyr Leu Ala Leu Pro Glu Arg Ala Glu 
145                 150                 155                 160 


Leu Ala Ala Ser Leu Gly Leu Thr Gln Thr Gln Val Lys Ile Trp Phe 
                165                 170                 175     


Gln Asn Lys Arg Ser Lys Phe Lys Lys Leu Met Lys Gln Gly Gly Ala 
            180                 185                 190         


Ala Leu Glu Gly Ser Ala Leu Ala Asn Gly Arg Ala Leu Ser Ala Gly 
        195                 200                 205             


Ser Pro Pro Val Pro Pro Gly Trp Asn Pro Asn Ser Ser Ser Gly Lys 
    210                 215                 220                 


Gly Ser Gly Gly Asn Ala Gly Ser Tyr Ile Pro Ser Tyr Thr Ser Trp 
225                 230                 235                 240 


Tyr Pro Ser Ala His Gln Glu Ala Met Gln Gln Pro Gln Leu Met 
                245                 250                 255 


<210> 2
<211> 2403
<212> DNA
<213> Homo sapiens

<400> 2
aagctttgaa ccgagtttgg ggagctcagc agcatcatgc ttagactttt caaagagaca       60

aactccattt tcttatgaat ggaaagtgaa aacccctgtt ccgcttaaat tgggttcctt      120

cctgtcctga gaaacataga gacccccaaa agggaagcag aggagagaaa gtcccacacc      180

cagaccccgc gagaagagat gaccatgacc accatgccag aaagtctcaa cagccccgtg      240

tcgggcaagg cggtgtttat ggagtttggg ccgcccaacc agcaaatgtc tccttctccc      300

atgtcccacg ggcactactc catgcactgt ttacactcgg cgggccattc gcagcccgac      360

ggcgcctaca gctcagcctc gtccttctcc cgaccgctgg gctaccccta cgtcaactcg      420

gtcagcagcc acgcatccag cccctacatc agttcggtgc agtcctaccc gggcagcgcc      480

agcctcgccc agagccgcct ggaggaccca ggggcggact cggagaagag cacggtggtg      540

gaaggcggtg aagtgcgctt caatggcaag ggaaaaaaga tccgtaaacc caggacgatt      600

tattccagtt tgcagttgca ggctttgaac cggaggttcc agcaaactca gtacctagct      660

ctgccggaga gggcggagct cgcggcctct ttgggactca cacagactca ggtcaagatc      720

tggttccaaa acaagcgatc caagttcaag aagctgatga agcagggtgg ggcggctctg      780

gagggtagtg cgttggccaa cggtcgggcc ctgtctgctg gctccccacc cgtgccgccc      840

ggctggaacc ctaactcttc atccgggaag ggctcaggag gaaacgcggg ctcctatatc      900

cccagctaca catcgtggta cccttcagcg caccaagaag ctatgcagca accccaactt      960

atgtgaggtt gcccgcccgt ctccttcttg tctccccggc ccaggtccct cccgcctcca     1020

ggtccatcca tcccgtccgg aaaagaagga cccagaggga agaaggaaca gtggaggcgg     1080

gacgccctcc atctcctcgg agccccgcga ggtccggccc agcaacttcc cggcatccgc     1140

gctctagcct gaaccctggc ctgggccgag cagtggcagc agagagtggc ctcggaggga     1200

agccactgcc acctgagaca gcccaagcag caagataaac ccgctccacc cgacccgccg     1260

accttcagct ttgtgggact atcaggaaaa aacaaaacaa aaacaaaatg tagaaaaagc     1320

aaaagctctt ttctgtcctg tcagtctcct gtctcctttt gctctgtctg tgcgctggta     1380

aagtccaggt cctcatccgt ccgctgtcct cattctgcgg cctcagcaaa aagccacaag     1440

gtctgagcgg cccgggtcct gccgggctga ccatctccgg atcctgggac actctgcctg     1500

accatctgtg tagctggtgt gggaatctgg gggcattgga gggagggggt tttatttatt     1560

gagaaatgga cttcgcctga ggctgtttgc caattcaggg ttctgctggg cgcaaggaac     1620

gcactgttca aacgcactgt ttactttaag cgcacgggga gaaacgaata aggaggacgt     1680

ggtgattttt aatttataca gtaacttttg tacttctctg gtatggagag tttggagccg     1740

aatgatttgc attttttaca tgtccgacat tatttaataa ataattttta aaagaaaaga     1800

acgataaatg aagccaacat gattttctca tttcgggagg aactctgttg cttcgcctgg     1860

acaagaagga aaatgctgat ttcctccttg ggtagaaaga gggagcgagg gcaaatgggg     1920

agtagagaga aaacaggcga gaacaagcac tctaattcca gtgggcttta aaataagaca     1980

aaatcagctt tacaacaatc cctagaggct cgaccacaga ataatgccag tcaccaccct     2040

gaacgcacaa tctccagtgc aggatctaat gactgtacat attattgtta ttattattat     2100

tgttattatt gttgttctgt aaacatgttg cacaagctta gcctttttgc gttctgttgt     2160

gtgtggctgt aaaaccccat gctttgtgaa atgagaatct tgacattttt cttgtgaaat     2220

ttggaaaatg tgatcaattg aaatcaactg tgttttgtgt tctctatgtc aaagtttagt     2280

tttatattga gaatgttaac ttattgcttt gtatcttggg aaaaaaactt tgtaaataag     2340

ttataaagtt tctttgagac agtaaaatta tgatttcttg aaaaaaaaaa aaaaaaaaaa     2400

aaa                                                                   2403


<210> 3
<211> 364
<212> PRT
<213> Homo sapiens

<400> 3
Met Met Leu Pro Ser Pro Val Thr Ser Thr Pro Phe Ser Val Lys Asp 
1               5                   10                  15      


Ile Leu Asn Leu Glu Gln Gln His Gln His Phe His Gly Ala His Leu 
            20                  25                  30          


Gln Ala Asp Leu Glu His His Phe His Ser Ala Pro Cys Met Leu Ala 
        35                  40                  45              


Ala Ala Glu Gly Thr Gln Phe Ser Asp Gly Gly Glu Glu Asp Glu Glu 
    50                  55                  60                  


Asp Glu Gly Glu Lys Leu Ser Tyr Leu Asn Ser Leu Ala Ala Ala Asp 
65                  70                  75                  80  


Gly His Gly Asp Ser Gly Leu Cys Pro Gln Gly Tyr Val His Thr Val 
                85                  90                  95      


Leu Arg Asp Ser Cys Ser Glu Pro Lys Glu His Glu Glu Glu Pro Glu 
            100                 105                 110         


Val Val Arg Asp Arg Ser Gln Lys Ser Cys Gln Leu Lys Lys Ser Leu 
        115                 120                 125             


Glu Thr Ala Gly Asp Cys Lys Ala Ala Glu Glu Ser Glu Arg Pro Lys 
    130                 135                 140                 


Pro Arg Ser Arg Arg Lys Pro Arg Val Leu Phe Ser Gln Ala Gln Val 
145                 150                 155                 160 


Phe Glu Leu Glu Arg Arg Phe Lys Gln Gln Arg Tyr Leu Ser Ala Pro 
                165                 170                 175     


Glu Arg Glu His Leu Ala Ser Ser Leu Lys Leu Thr Ser Thr Gln Val 
            180                 185                 190         


Lys Ile Trp Phe Gln Asn Arg Arg Tyr Lys Cys Lys Arg Gln Arg Gln 
        195                 200                 205             


Asp Lys Ser Leu Glu Leu Gly Ala His Ala Pro Pro Pro Pro Pro Arg 
    210                 215                 220                 


Arg Val Ala Val Pro Val Leu Val Arg Asp Gly Lys Pro Cys Val Thr 
225                 230                 235                 240 


Pro Ser Ala Gln Ala Tyr Gly Ala Pro Tyr Ser Val Gly Ala Ser Ala 
                245                 250                 255     


Tyr Ser Tyr Asn Ser Phe Pro Ala Tyr Gly Tyr Gly Asn Ser Ala Ala 
            260                 265                 270         


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Tyr Ser 
        275                 280                 285             


Ser Ser Tyr Gly Cys Ala Tyr Pro Ala Gly Gly Gly Gly Gly Gly Gly 
    290                 295                 300                 


Gly Thr Ser Ala Ala Thr Thr Ala Met Gln Pro Ala Cys Ser Ala Ala 
305                 310                 315                 320 


Gly Gly Gly Pro Phe Val Asn Val Ser Asn Leu Gly Gly Phe Gly Ser 
                325                 330                 335     


Gly Gly Ser Ala Gln Pro Leu His Gln Gly Thr Ala Ala Gly Ala Ala 
            340                 345                 350         


Cys Ala Gln Gly Thr Leu Gln Gly Ile Arg Ala Trp 
        355                 360                 


<210> 4
<211> 2117
<212> DNA
<213> Homo sapiens

<400> 4
agtccctgca gtggctgtaa caaaacccag acccccaggt cccggccaat ggaggcgatt       60

tagactggag tgggaccgcg tctgtcaaaa gcccgactcg gcagcagcgg cggagtccag      120

gaggagagct ggagccgccg cgctgcctcc ccgcccccgc cgggatttat tatttggact      180

ggacaattaa gtggccctga tgatgttacc aagcccggtc acctccaccc ctttctcagt      240

caaagacatt ttgaatctgg agcagcagca ccagcacttc catggtgcgc acttgcaggc      300

ggacttggag caccacttcc actctgcgcc ctgcatgctg gccgccgctg aggggacgca      360

attttctgac ggaggggagg aggacgagga agacgagggc gagaaattgt cctatttgaa      420

ctcactagcc gcagcagacg gccacgggga ttcagggctg tgtccccagg gctatgtcca      480

cacggtcctg cgagactcgt gcagcgagcc caaggaacat gaagaggagc ccgaggtcgt      540

gagggaccgg agccaaaaaa gctgccagct gaagaagtct ctagagacgg ccggagactg      600

caaggcggcg gaggagagcg agaggccgaa gccacgcagc cgccggaagc cccgggtcct      660

cttctcgcaa gcccaggtct tcgagctgga acgcaggttc aagcagcagc ggtacctgtc      720

ggcacccgag cgcgagcacc tcgccagcag cctgaagctc acatccactc aggtgaaaat      780

ctggttccag aatcgcaggt acaagtgcaa gagacagcgg caggacaagt ctctggagct      840

tggcgcacac gcgcccccgc cgccgccgcg ccgcgtggct gtcccggtgc tggtgcggga      900

cggcaagccg tgcgtcacgc ccagcgcgca ggcctacggc gcgccctaca gcgtgggcgc      960

cagcgcctac tcctacaaca gcttccccgc ctacggctat gggaactcgg ccgcggccgc     1020

cgccgccgcc gccgccgccg ccgcagcagc ggcggcctac agcagcagct atggctgtgc     1080

gtacccggcg ggcggcggcg gcggcggcgg cgggacctcc gcggcgacca ctgccatgca     1140

gcccgcctgc agcgcggccg gaggcggccc ctttgtgaac gtgagcaacc taggaggctt     1200

cggcagcggc ggcagcgcac agccgttgca ccagggtact gcagccgggg ccgcgtgcgc     1260

tcagggcacc ttgcagggca tccgggcctg gtagggacgg ggcgggtcac gcggcgggca     1320

ccccagcgca gcctggcgcc gcgggactga agctcgagaa gggcctgacc taaaggtcag     1380

gtcccctcgt taaaaaaata tgtacgtcta gctcctcagg gcttcggatc gcagctcact     1440

cgaggcctgg ggaaggggac tcaggggcga ggaggatgac tgggtccggt cgccaggact     1500

gtctctgagg cagaaacgcc ggctgggcgc cggggaggac gatggccccg accctggcag     1560

cgagaggaga ccaggaggct aggaccctgg ccgcgcttgg ttcttccaaa gcgagaaggg     1620

cttctctccc tctgcctttc cgcggcctcc gcgaagcgtt ggcggggagc ccaaggacat     1680

aacaaattaa aagcatgaag gagagaaaaa tgggggtcgt ggcttgagaa attccaggcc     1740

ctaccgatcc tctgccccct ttgcgggcct ggagcgccat agcacagtcg atttcgtttc     1800

gcagctgtct cccctccgca gcagatacct cggtccagat ctccggattg tcgggggacg     1860

caggactctt cgaggaaaac cagccgaatg agatcaaaag ttgggggtgg ggggaggctg     1920

aacaaactca ggacctggtg gcccaccgga ggtgttaccg ggtttccttt ctgtttcgta     1980

ttctgtattc agcacatgtt atctatctat ctatctatat aactataacc acacgccgtg     2040

tagacacccg ctgccacaca ctacaggagt caataaacaa ggtgcaatat tttcaaaaaa     2100

aaaaaaaaaa aaaaaaa                                                    2117


<210> 5
<211> 258
<212> PRT
<213> Homo sapiens

<400> 5
Met Lys Gln Ile Leu His Pro Ala Leu Glu Thr Thr Ala Met Thr Leu 
1               5                   10                  15      


Phe Pro Val Leu Leu Phe Leu Val Ala Gly Leu Leu Pro Ser Phe Pro 
            20                  25                  30          


Ala Asn Glu Asp Lys Asp Pro Ala Phe Thr Ala Leu Leu Thr Thr Gln 
        35                  40                  45              


Thr Gln Val Gln Arg Glu Ile Val Asn Lys His Asn Glu Leu Arg Arg 
    50                  55                  60                  


Ala Val Ser Pro Pro Ala Arg Asn Met Leu Lys Met Glu Trp Asn Lys 
65                  70                  75                  80  


Glu Ala Ala Ala Asn Ala Gln Lys Trp Ala Asn Gln Cys Asn Tyr Arg 
                85                  90                  95      


His Ser Asn Pro Lys Asp Arg Met Thr Ser Leu Lys Cys Gly Glu Asn 
            100                 105                 110         


Leu Tyr Met Ser Ser Ala Ser Ser Ser Trp Ser Gln Ala Ile Gln Ser 
        115                 120                 125             


Trp Phe Asp Glu Tyr Asn Asp Phe Asp Phe Gly Val Gly Pro Lys Thr 
    130                 135                 140                 


Pro Asn Ala Val Val Gly His Tyr Thr Gln Val Val Trp Tyr Ser Ser 
145                 150                 155                 160 


Tyr Leu Val Gly Cys Gly Asn Ala Tyr Cys Pro Asn Gln Lys Val Leu 
                165                 170                 175     


Lys Tyr Tyr Tyr Val Cys Gln Tyr Cys Pro Ala Gly Asn Trp Ala Asn 
            180                 185                 190         


Arg Leu Tyr Val Pro Tyr Glu Gln Gly Ala Pro Cys Ala Ser Cys Pro 
        195                 200                 205             


Asp Asn Cys Asp Asp Gly Leu Cys Thr Asn Gly Cys Lys Tyr Glu Asp 
    210                 215                 220                 


Leu Tyr Ser Asn Cys Lys Ser Leu Lys Leu Thr Leu Thr Cys Lys His 
225                 230                 235                 240 


Gln Leu Val Arg Asp Ser Cys Lys Ala Ser Cys Asn Cys Ser Asn Ser 
                245                 250                 255     


Ile Tyr 
        


<210> 6
<211> 2219
<212> DNA
<213> Homo sapiens

<400> 6
gcacaaccag aatttgccaa aacaggaaat aggtgtttca tatatacggc tctaaccttc       60

tctctctgca ccttccttct gtcaatagat gaaacaaata cttcatcctg ctctggaaac      120

cactgcaatg acattattcc cagtgctgtt gttcctggtt gctgggctgc ttccatcttt      180

tccagcaaat gaagataagg atcccgcttt tactgctttg ttaaccaccc aaacacaagt      240

gcaaagggag attgtgaata agcacaatga actgaggaga gcagtatctc cccctgccag      300

aaacatgctg aagatggaat ggaacaaaga ggctgcagca aatgcccaaa agtgggcaaa      360

ccagtgcaat tacagacaca gtaacccaaa ggatcgaatg acaagtctaa aatgtggtga      420

gaatctctac atgtcaagtg cctccagctc atggtcacaa gcaatccaaa gctggtttga      480

tgagtacaat gattttgact ttggtgtagg gccaaagact cccaacgcag tggttggaca      540

ttatacacag gttgtttggt actcttcata cctcgttgga tgtggaaatg cctactgtcc      600

caatcaaaaa gttctaaaat actactatgt ttgccaatat tgtcctgctg gtaattgggc      660

taatagacta tatgtccctt atgaacaagg agcaccttgt gccagttgcc cagataactg      720

tgacgatgga ctatgcacca atggttgcaa gtacgaagat ctctatagta actgtaaaag      780

tttgaagctc acattaacct gtaaacatca gttggtcagg gacagttgca aggcctcctg      840

caattgttca aacagcattt attaaatacg cattacacac cgagtagggc tatgtagaga      900

ggagtcagat tatctactta gatttggcat ctacttagat ttaacatata ctagctgaga      960

aattgtaggc atgtttgata cacatttgat ttcaaatgtt tttcttctgg atctgctttt     1020

tattttacaa aaatattttt catacaaatg gttaaaaaga aacaaaatct ataacaacaa     1080

ctttggattt ttatatataa actttgtgat ttaaatttac tgaatttaat tagggtgaaa     1140

attttgaaag ttgtattctc atatgactaa gttcactaaa accctggatt gaaagtgaaa     1200

attatgttcc tagaacaaaa tgtacaaaaa gaacaatata attttcacat gaacccttgg     1260

ctgtagttgc ctttcctagc tccactctaa ggctaagcat cttcaaagac gttttcccat     1320

atgctgtctt aattcttttc actcattcac ccttcttccc aatcatctgg ctggcatcct     1380

cacaattgag ttgaagctgt tcctcctaaa acaatcctga cttttatttt gccaaaatca     1440

atacaatcct ttgaattttt tatctgcata aattttacag tagaatatga tcaaaccttc     1500

atttttaaac ctctcttctc tttgacaaaa cttccttaaa aaagaataca agataatata     1560

ggtaaatacc ctccactcaa ggaggtagaa ctcagtcctc tcccttgtga gtcttcacta     1620

aaatcagtga ctcacttcca aagagtggag tatggaaagg gaaacatagt aactttacag     1680

gggagaaaaa tgacaaatga cgtcttcacc aagtgatcaa aattaacgtc accagtgata     1740

agtcattcag atttgttcta gataatcttt ctaaaaattc ataatcccaa tctaattatg     1800

agctaaaaca tccagcaaac tcaagttgaa ggacattcta caaaatatcc ctggggtatt     1860

ttagagtatt cctcaaaact gtaaaaatca tggaaaataa gggaatcctg agaaacaatc     1920

acagaccaca tgagactaag gagacatgtg agccaaatgc aatgtgcttc ttggatcaga     1980

tcctggaaca gaaaaagatc agtaatgaaa aaactgatga agtctgaata gaatctggag     2040

tatttttaac agtagtgttg atttcttaat cttgataaat atagcagggt aatgtaagat     2100

gataacgtta gagaaactga aactgggtga gggctatcta ggaattctct gtactatctt     2160

accaaatttt cggtaagtct aagaaagcaa tgcaaaataa aaagtgtctt gaaaaaaaa      2219


<210> 7
<211> 82
<212> PRT
<213> Homo sapiens

<400> 7
Met Asp Pro Gly Pro Lys Gly His Cys His Cys Gly Gly His Gly His 
1               5                   10                  15      


Pro Pro Gly His Cys Gly Pro Pro Pro Gly His Gly Pro Gly Pro Cys 
            20                  25                  30          


Gly Pro Pro Pro His His Gly Pro Gly Pro Cys Gly Pro Pro Pro Gly 
        35                  40                  45              


His Gly Pro Gly Pro Cys Gly Pro Pro Pro His His Gly Pro Gly Pro 
    50                  55                  60                  


Cys Gly Pro Pro Pro Gly His Gly Pro Gly His Pro Pro Pro Gly Pro 
65                  70                  75                  80  


His His 
        


<210> 8
<211> 464
<212> DNA
<213> Homo sapiens

<400> 8
agacttcctg cccctgctct gcactctcag gtattccctg ctcttactcc aaaaagatgg       60

acccaggtcc gaaggggcac tgccactgtg gggggcatgg ccatcctcca ggtcactgcg      120

ggccaccccc tggccatggc ccagggccct gcgggccacc cccccaccat ggtccagggc      180

cctgcgggcc accccctggc catggcccag ggccctgcgg gccacccccc caccatggtc      240

cagggccctg cgggcctccc cctggccatg gcccaggtca cccaccccct ggtccacatc      300

actgaggaag tagaagaaaa caggacacaa gatggcaagc ctgagagaat tgcccagctg      360

acctggaatg aggcctaaac cacaatcttc tcttcctaat aaacagcctc ctagaggcca      420

cattctattc tttaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa                       464


<210> 9
<211> 961
<212> PRT
<213> Homo sapiens

<400> 9
Met Leu Ala Pro Arg Gly Ala Ala Val Leu Leu Leu His Leu Val Leu 
1               5                   10                  15      


Gln Arg Trp Leu Ala Ala Gly Ala Gln Ala Thr Pro Gln Val Phe Asp 
            20                  25                  30          


Leu Leu Pro Ser Ser Ser Gln Arg Leu Asn Pro Gly Ala Leu Leu Pro 
        35                  40                  45              


Val Leu Thr Asp Pro Ala Leu Asn Asp Leu Tyr Val Ile Ser Thr Phe 
    50                  55                  60                  


Lys Leu Gln Thr Lys Ser Ser Ala Thr Ile Phe Gly Leu Tyr Ser Ser 
65                  70                  75                  80  


Thr Asp Asn Ser Lys Tyr Phe Glu Phe Thr Val Met Gly Arg Leu Asn 
                85                  90                  95      


Lys Ala Ile Leu Arg Tyr Leu Lys Asn Asp Gly Lys Val His Leu Val 
            100                 105                 110         


Val Phe Asn Asn Leu Gln Leu Ala Asp Gly Arg Arg His Arg Ile Leu 
        115                 120                 125             


Leu Arg Leu Ser Asn Leu Gln Arg Gly Ala Gly Ser Leu Glu Leu Tyr 
    130                 135                 140                 


Leu Asp Cys Ile Gln Val Asp Ser Val His Asn Leu Pro Arg Ala Phe 
145                 150                 155                 160 


Ala Gly Pro Ser Gln Lys Pro Glu Thr Ile Glu Leu Arg Thr Phe Gln 
                165                 170                 175     


Arg Lys Pro Gln Asp Phe Leu Glu Glu Leu Lys Leu Val Val Arg Gly 
            180                 185                 190         


Ser Leu Phe Gln Val Ala Ser Leu Gln Asp Cys Phe Leu Gln Gln Ser 
        195                 200                 205             


Glu Pro Leu Ala Ala Thr Gly Thr Gly Asp Phe Asn Arg Gln Phe Leu 
    210                 215                 220                 


Gly Gln Met Thr Gln Leu Asn Gln Leu Leu Gly Glu Val Lys Asp Leu 
225                 230                 235                 240 


Leu Arg Gln Gln Val Lys Glu Thr Ser Phe Leu Arg Asn Thr Ile Ala 
                245                 250                 255     


Glu Cys Gln Ala Cys Gly Pro Leu Lys Phe Gln Ser Pro Thr Pro Ser 
            260                 265                 270         


Thr Val Val Pro Pro Ala Pro Pro Ala Pro Pro Thr Arg Pro Pro Arg 
        275                 280                 285             


Arg Cys Asp Ser Asn Pro Cys Phe Arg Gly Val Gln Cys Thr Asp Ser 
    290                 295                 300                 


Arg Asp Gly Phe Gln Cys Gly Pro Cys Pro Glu Gly Tyr Thr Gly Asn 
305                 310                 315                 320 


Gly Ile Thr Cys Ile Asp Val Asp Glu Cys Lys Tyr His Pro Cys Tyr 
                325                 330                 335     


Pro Gly Val His Cys Ile Asn Leu Ser Pro Gly Phe Arg Cys Asp Ala 
            340                 345                 350         


Cys Pro Val Gly Phe Thr Gly Pro Met Val Gln Gly Val Gly Ile Ser 
        355                 360                 365             


Phe Ala Lys Ser Asn Lys Gln Val Cys Thr Asp Ile Asp Glu Cys Arg 
    370                 375                 380                 


Asn Gly Ala Cys Val Pro Asn Ser Ile Cys Val Asn Thr Leu Gly Ser 
385                 390                 395                 400 


Tyr Arg Cys Gly Pro Cys Lys Pro Gly Tyr Thr Gly Asp Gln Ile Arg 
                405                 410                 415     


Gly Cys Lys Ala Glu Arg Asn Cys Arg Asn Pro Glu Leu Asn Pro Cys 
            420                 425                 430         


Ser Val Asn Ala Gln Cys Ile Glu Glu Arg Gln Gly Asp Val Thr Cys 
        435                 440                 445             


Val Cys Gly Val Gly Trp Ala Gly Asp Gly Tyr Ile Cys Gly Lys Asp 
    450                 455                 460                 


Val Asp Ile Asp Ser Tyr Pro Asp Glu Glu Leu Pro Cys Ser Ala Arg 
465                 470                 475                 480 


Asn Cys Lys Lys Asp Asn Cys Lys Tyr Val Pro Asn Ser Gly Gln Glu 
                485                 490                 495     


Asp Ala Asp Arg Asp Gly Ile Gly Asp Ala Cys Asp Glu Asp Ala Asp 
            500                 505                 510         


Gly Asp Gly Ile Leu Asn Glu Gln Asp Asn Cys Val Leu Ile His Asn 
        515                 520                 525             


Val Asp Gln Arg Asn Ser Asp Lys Asp Ile Phe Gly Asp Ala Cys Asp 
    530                 535                 540                 


Asn Cys Leu Ser Val Leu Asn Asn Asp Gln Lys Asp Thr Asp Gly Asp 
545                 550                 555                 560 


Gly Arg Gly Asp Ala Cys Asp Asp Asp Met Asp Gly Asp Gly Ile Lys 
                565                 570                 575     


Asn Ile Leu Asp Asn Cys Pro Lys Phe Pro Asn Arg Asp Gln Arg Asp 
            580                 585                 590         


Lys Asp Gly Asp Gly Val Gly Asp Ala Cys Asp Ser Cys Pro Asp Val 
        595                 600                 605             


Ser Asn Pro Asn Gln Ser Asp Val Asp Asn Asp Leu Val Gly Asp Ser 
    610                 615                 620                 


Cys Asp Thr Asn Gln Asp Ser Asp Gly Asp Gly His Gln Asp Ser Thr 
625                 630                 635                 640 


Asp Asn Cys Pro Thr Val Ile Asn Ser Ala Gln Leu Asp Thr Asp Lys 
                645                 650                 655     


Asp Gly Ile Gly Asp Glu Cys Asp Asp Asp Asp Asp Asn Asp Gly Ile 
            660                 665                 670         


Pro Asp Leu Val Pro Pro Gly Pro Asp Asn Cys Arg Leu Val Pro Asn 
        675                 680                 685             


Pro Ala Gln Glu Asp Ser Asn Ser Asp Gly Val Gly Asp Ile Cys Glu 
    690                 695                 700                 


Ser Asp Phe Asp Gln Asp Gln Val Ile Asp Arg Ile Asp Val Cys Pro 
705                 710                 715                 720 


Glu Asn Ala Glu Val Thr Leu Thr Asp Phe Arg Ala Tyr Gln Thr Val 
                725                 730                 735     


Val Leu Asp Pro Glu Gly Asp Ala Gln Ile Asp Pro Asn Trp Val Val 
            740                 745                 750         


Leu Asn Gln Gly Met Glu Ile Val Gln Thr Met Asn Ser Asp Pro Gly 
        755                 760                 765             


Leu Ala Val Gly Tyr Thr Ala Phe Asn Gly Val Asp Phe Glu Gly Thr 
    770                 775                 780                 


Phe His Val Asn Thr Gln Thr Asp Asp Asp Tyr Ala Gly Phe Ile Phe 
785                 790                 795                 800 


Gly Tyr Gln Asp Ser Ser Ser Phe Tyr Val Val Met Trp Lys Gln Thr 
                805                 810                 815     


Glu Gln Thr Tyr Trp Gln Ala Thr Pro Phe Arg Ala Val Ala Glu Pro 
            820                 825                 830         


Gly Ile Gln Leu Lys Ala Val Lys Ser Lys Thr Gly Pro Gly Glu His 
        835                 840                 845             


Leu Arg Asn Ser Leu Trp His Thr Gly Asp Thr Ser Asp Gln Val Arg 
    850                 855                 860                 


Leu Leu Trp Lys Asp Ser Arg Asn Val Gly Trp Lys Asp Lys Val Ser 
865                 870                 875                 880 


Tyr Arg Trp Phe Leu Gln His Arg Pro Gln Val Gly Tyr Ile Arg Val 
                885                 890                 895     


Arg Phe Tyr Glu Gly Ser Glu Leu Val Ala Asp Ser Gly Val Thr Ile 
            900                 905                 910         


Asp Thr Thr Met Arg Gly Gly Arg Leu Gly Val Phe Cys Phe Ser Gln 
        915                 920                 925             


Glu Asn Ile Ile Trp Ser Asn Leu Lys Tyr Arg Cys Asn Asp Thr Ile 
    930                 935                 940                 


Pro Glu Asp Phe Gln Glu Phe Gln Thr Gln Asn Phe Asp Arg Phe Asp 
945                 950                 955                 960 


Asn 
    


<210> 10
<211> 3233
<212> DNA
<213> Homo sapiens

<400> 10
cagcagccag ctccccagca ccgcacggcg gggacgcgag cgcgcccccg acggcagccc       60

ggacgccgag cacgggtcac ctgcggcgcc ggcccgggcg ccgaccgagg ttcaacgcac      120

ggcccgggga cccccaggcg gggccaacgc cgccgtcgcc cccggcctcg cggggagcag      180

gaagagccaa catgctggcc ccgcgcggag ccgccgtcct cctgctgcac ctggtcctgc      240

agcggtggct agcggcaggc gcccaggcca ccccccaggt ctttgacctt ctcccatctt      300

ccagtcagag gctaaaccca ggcgctctgc tgccagtcct gacagacccc gccctgaatg      360

atctctatgt gatttccacc ttcaagctgc agactaaaag ttcagccacc atcttcggtc      420

tttactcttc aactgacaac agtaaatatt ttgaatttac tgtgatggga cgcttaaaca      480

aagccatcct ccgttacctg aagaacgatg ggaaggtgca tttggtggtt ttcaacaacc      540

tgcagctggc agacggaagg cggcacagga tcctcctgag gctgagcaat ttgcagcgag      600

gggccggctc cctagagctc tacctggact gcatccaggt ggattccgtt cacaatctcc      660

ccagggcctt tgctggcccc tcccagaaac ctgagaccat tgaattgagg actttccaga      720

ggaagccaca ggacttcttg gaagagctga agctggtggt gagaggctca ctgttccagg      780

tggccagcct gcaagactgc ttcctgcagc agagtgagcc actggctgcc acaggcacag      840

gggactttaa ccggcagttc ttgggtcaaa tgacacaatt aaaccaactc ctgggagagg      900

tgaaggacct tctgagacag caggttaagg aaacatcatt tttgcgaaac accatagctg      960

aatgccaggc ttgcggtcct ctcaagtttc agtctccgac cccaagcacg gtggtgcccc     1020

cggctccccc tgcaccgcca acacgcccac ctcgtcggtg tgactccaac ccatgtttcc     1080

gaggtgtcca atgtaccgac agtagagatg gcttccagtg tgggccctgc cccgagggct     1140

acacaggaaa cgggatcacc tgtattgatg ttgatgagtg caaataccat ccctgctacc     1200

cgggcgtgca ctgcataaat ttgtctcctg gcttcagatg tgacgcctgc ccagtgggct     1260

tcacagggcc catggtgcag ggtgttggga tcagttttgc caagtcaaac aagcaggtct     1320

gcactgacat tgatgagtgt cgaaatggag cgtgcgttcc caactcgatc tgcgttaata     1380

ctttgggatc ttaccgctgt gggccttgta agccggggta tactggtgat cagataaggg     1440

gatgcaaagc ggaaagaaac tgcagaaacc cagagctgaa cccttgcagt gtgaatgccc     1500

agtgcattga agagaggcag ggggatgtga catgtgtgtg tggagtcggt tgggctggag     1560

atggctatat ctgtggaaag gatgtggaca tcgacagtta ccccgacgaa gaactgccat     1620

gctctgccag gaactgtaaa aaggacaact gcaaatatgt gccaaattct ggccaagaag     1680

atgcagacag agatggcatt ggcgacgctt gtgacgagga tgctgacgga gatgggatcc     1740

tgaatgagca ggataactgt gtcctgattc ataatgtgga ccaaaggaac agcgataaag     1800

atatctttgg ggatgcctgt gataactgcc tgagtgtctt aaataacgac cagaaagaca     1860

ccgatgggga tggaagagga gatgcctgtg atgatgacat ggatggagat ggaataaaaa     1920

acattctgga caactgccca aaatttccca atcgtgacca acgggacaag gatggtgatg     1980

gtgtggggga tgcctgtgac agttgtcctg atgtcagcaa ccctaaccag tctgatgtgg     2040

ataatgatct ggttggggac tcctgtgaca ccaatcagga cagtgatgga gatgggcacc     2100

aggacagcac agacaactgc cccaccgtca ttaacagtgc ccagctggac accgataagg     2160

atggaattgg tgacgagtgt gatgatgatg atgacaatga tggtatccca gacctggtgc     2220

cccctggacc agacaactgc cggctggtcc ccaacccagc ccaggaggat agcaacagcg     2280

acggagtggg agacatctgt gagtctgact ttgaccagga ccaggtcatc gatcggatcg     2340

acgtctgccc agagaacgca gaggtcaccc tgaccgactt cagggcttac cagaccgtgg     2400

tcctggatcc tgaaggggat gcccagatcg atcccaactg ggtggtcctg aaccagggca     2460

tggagattgt acagaccatg aacagtgatc ctggcctggc agtggggtac acagctttta     2520

atggagttga cttcgaaggg accttccatg tgaataccca gacagatgat gactatgcag     2580

gctttatctt tggctaccaa gatagctcca gcttctacgt ggtcatgtgg aagcagacgg     2640

agcagacata ttggcaagcc accccattcc gagcagttgc agaacctggc attcagctca     2700

aggctgtgaa gtctaagaca ggtccagggg agcatctccg gaactccctg tggcacacgg     2760

gggacaccag tgaccaggtc aggctgctgt ggaaggactc caggaatgtg ggctggaagg     2820

acaaggtgtc ctaccgctgg ttcctacagc acaggcccca ggtgggctac atcagggtac     2880

gattttatga aggctctgag ttggtggctg actctggcgt caccatagac accacaatgc     2940

gtggaggccg acttggcgtt ttctgcttct ctcaagaaaa catcatctgg tccaacctca     3000

agtatcgctg caatgacacc atccctgagg acttccaaga gtttcaaacc cagaatttcg     3060

accgcttcga taattaaacc aaggaagcaa tctgtaactg cttttcggaa cactaaaacc     3120

atatatattt taacttcaat tttctttagc ttttaccaac ccaaatatat caaaacgttt     3180

tatgtgaatg tggcaataaa ggagaagaga tcatttttaa aaaaaaaaaa aaa            3233


<210> 11
<211> 382
<212> PRT
<213> Homo sapiens

<400> 11
Met Ala Leu Gln Gly Ile Ser Val Val Glu Leu Ser Gly Leu Ala Pro 
1               5                   10                  15      


Gly Pro Phe Cys Ala Met Val Leu Ala Asp Phe Gly Ala Arg Val Val 
            20                  25                  30          


Arg Val Asp Arg Pro Gly Ser Arg Tyr Asp Val Ser Arg Leu Gly Arg 
        35                  40                  45              


Gly Lys Arg Ser Leu Val Leu Asp Leu Lys Gln Pro Arg Gly Ala Ala 
    50                  55                  60                  


Val Leu Arg Arg Leu Cys Lys Arg Ser Asp Val Leu Leu Glu Pro Phe 
65                  70                  75                  80  


Arg Arg Gly Val Met Glu Lys Leu Gln Leu Gly Pro Glu Ile Leu Gln 
                85                  90                  95      


Arg Glu Asn Pro Arg Leu Ile Tyr Ala Arg Leu Ser Gly Phe Gly Gln 
            100                 105                 110         


Ser Gly Ser Phe Cys Arg Leu Ala Gly His Asp Ile Asn Tyr Leu Ala 
        115                 120                 125             


Leu Ser Gly Val Leu Ser Lys Ile Gly Arg Ser Gly Glu Asn Pro Tyr 
    130                 135                 140                 


Ala Pro Leu Asn Leu Leu Ala Asp Phe Ala Gly Gly Gly Leu Met Cys 
145                 150                 155                 160 


Ala Leu Gly Ile Ile Met Ala Leu Phe Asp Arg Thr Arg Thr Gly Lys 
                165                 170                 175     


Gly Gln Val Ile Asp Ala Asn Met Val Glu Gly Thr Ala Tyr Leu Ser 
            180                 185                 190         


Ser Phe Leu Trp Lys Thr Gln Lys Leu Ser Leu Trp Glu Ala Pro Arg 
        195                 200                 205             


Gly Gln Asn Met Leu Asp Gly Gly Ala Pro Phe Tyr Thr Thr Tyr Arg 
    210                 215                 220                 


Thr Ala Asp Gly Glu Phe Met Ala Val Gly Ala Ile Glu Pro Gln Phe 
225                 230                 235                 240 


Tyr Glu Leu Leu Ile Lys Gly Leu Gly Leu Lys Ser Asp Glu Leu Pro 
                245                 250                 255     


Asn Gln Met Ser Met Asp Asp Trp Pro Glu Met Lys Lys Lys Phe Ala 
            260                 265                 270         


Asp Val Phe Ala Glu Lys Thr Lys Ala Glu Trp Cys Gln Ile Phe Asp 
        275                 280                 285             


Gly Thr Asp Ala Cys Val Thr Pro Val Leu Thr Phe Glu Glu Val Val 
    290                 295                 300                 


His His Asp His Asn Lys Glu Arg Gly Ser Phe Ile Thr Ser Glu Glu 
305                 310                 315                 320 


Gln Asp Val Ser Pro Arg Pro Ala Pro Leu Leu Leu Asn Thr Pro Ala 
                325                 330                 335     


Ile Pro Ser Phe Lys Arg Asp Pro Phe Ile Gly Glu His Thr Glu Glu 
            340                 345                 350         


Ile Leu Glu Glu Phe Gly Phe Ser Arg Glu Glu Ile Tyr Gln Leu Asn 
        355                 360                 365             


Ser Asp Lys Ile Ile Glu Ser Asn Lys Val Lys Ala Ser Leu 
    370                 375                 380         


<210> 12
<211> 3352
<212> DNA
<213> Homo sapiens

<400> 12
ggggcgtggc gccggggatt gggagggctt cttgcaggct gctgggctgg ggctaagggc       60

tgctcagttt ccttcagcgg ggcactggga agcgccatgg cactgcaggg catctcggtc      120

gtggagctgt ccggcctggc cccgggcccg ttctgtgcta tggtcctggc tgacttcggg      180

gcgcgtgtgg tacgcgtgga ccggcccggc tcccgctacg acgtgagccg cttgggccgg      240

ggcaagcgct cgctagtgct ggacctgaag cagccgcggg gagccgccgt gctgcggcgt      300

ctgtgcaagc ggtcggatgt gctgctggag cccttccgcc gcggtgtcat ggagaaactc      360

cagctgggcc cagagattct gcagcgggaa aatccaaggc ttatttatgc caggctgagt      420

ggatttggcc agtcaggaag cttctgccgg ttagctggcc acgatatcaa ctatttggct      480

ttgtcaggtg ttctctcaaa aattggcaga agtggtgaga atccgtatgc cccgctgaat      540

ctcctggctg actttgctgg tggtggcctt atgtgtgcac tgggcattat aatggctctt      600

tttgaccgca cacgcactgg caagggtcag gtcattgatg caaatatggt ggaaggaaca      660

gcatatttaa gttcttttct gtggaaaact cagaaattga gtctgtggga agcacctcga      720

ggacagaaca tgttggatgg tggagcacct ttctatacga cttacaggac agcagatggg      780

gaattcatgg ctgttggagc aatagaaccc cagttctacg agctgctgat caaaggactt      840

ggactaaagt ctgatgaact tcccaatcag atgagcatgg atgattggcc agaaatgaag      900

aagaagtttg cagatgtatt tgcagagaag acgaaggcag agtggtgtca aatctttgac      960

ggcacagatg cctgtgtgac tccggttctg acttttgagg aggttgttca tcatgatcac     1020

aacaaggaac ggggctcgtt tatcaccagt gaggagcagg acgtgagccc ccgccctgca     1080

cctctgctgt taaacacccc agccatccct tctttcaaaa gggatccttt cataggagaa     1140

cacactgagg agatacttga agaatttgga ttcagccgcg aagagattta tcagcttaac     1200

tcagataaaa tcattgaaag taataaggta aaagctagtc tctaacttcc aggcccacgg     1260

ctcaagtgaa tttgaatact gcatttacag tgtagagtaa cacataacat tgtatgcatg     1320

gaaacatgga ggaacagtat tacagtgtcc taccactcta atcaagaaaa gaattacaga     1380

ctctgattct acagtgatga ttgaattcta aaaatggtta tcattagggc ttttgattta     1440

taaaactttg ggtacttata ctaaattatg gtagttattc tgccttccag tttgcttgat     1500

atatttgttg atattaagat tcttgactta tattttgaat gggttctagt gaaaaaggaa     1560

tgatatattc ttgaagacat cgatatacat ttatttacac tcttgattct acaatgtaga     1620

aaatgaggaa atgccacaaa ttgtatggtg ataaaagtca cgtgaaacag agtgattggt     1680

tgcatccagg ccttttgtct tggtgttcat gatctccctc taagcacatt ccaaacttta     1740

gcaacagtta tcacactttg taatttgcaa agaaaagttt cacctgtatt gaatcagaat     1800

gccttcaact gaaaaaaaca tatccaaaat aatgaggaaa tgtgttggct cactacgtag     1860

agtccagagg gacagtcagt tttagggttg cctgtatcca gtaactcggg gcctgtttcc     1920

ccgtgggtct ctgggctgtc agctttcctt tctccatgtg tttgatttct cctcaggctg     1980

gtagcaagtt ctggatctta tacccaacac acagcaacat ccagaaataa agatctcagg     2040

accccccagc aagtcgtttt gtgtctcctt ggactgagtt aagttacaag cctttcttat     2100

acctgtcttt gacaaagaag acgggattgt ctttacataa aaccagcctg ctcctggagc     2160

ttccctggac tcaacttcct aaaggcatgt gaggaagggg tagattccac aatctaatcc     2220

gggtgccatc agagtagagg gagtagagaa tggatgttgg gtaggccatc aataaggtcc     2280

attctgcgca gtatctcaac tgccgttcaa caatcgcaag aggaaggtgg agcaggtttc     2340

ttcatcttac agttgagaaa acagagactc agaagggctt cttagttcat gtttccctta     2400

gcgcctcagt gattttttca tggtggctta ggccaaaaga aatatctaac cattcaattt     2460

ataaataatt aggtccccaa cgaattaaat attatgtcct accaacttat tagctgcttg     2520

aaaaatataa tacacataaa taaaaaaata tatttttcat ttctatttca ttgttaatca     2580

caactactta ctaaggagat gtatgcacct attggacact gtgcaacttc tcacctggaa     2640

tgagattgga cactgctgcc ctcattttct gctccatgtt ggtgtccata tagtacttga     2700

ttttttatca gatggcctgg aaaacccagt ctcacaaaaa tatgaaatta tcagaaggat     2760

tatagtgcaa tcttatgttg aaagaatgaa ctacctcact agtagttcac gtgatgtctg     2820

acagatgttg agtttcattg tgtttgtgtg ttcaaatttt taaatattct gagatactct     2880

tgtgaggtca ctctaatgcc ctgggtgcct tggcacagtt ttagaaatac cagttgaaaa     2940

tatttgctca ggaatatgca actaggaagg ggcagaatca gaatttaagc tttcatattc     3000

tagccttcag tcttgttctt caaccatttt taggaacttt cccataaggt tatgttttcc     3060

agcccaggca tggaggatca cttgaggcca agagttcgag accagcctgg ggaacttggc     3120

tggacctccg tttctacgaa ataaaaataa aaaaattatc caggtatggt ggtgtgtgcc     3180

tgtagtccta tctactcaag ggtggggcag gaggatcact tgagcccagg aatttgaggc     3240

cacagtgaat taggattgca ccactgcact ctagcccagg caacagaaca agaacctgtc     3300

tctaaataaa taaataaaaa taataataat aaaaaagatg ttttccctac aa             3352


<210> 13
<211> 238
<212> PRT
<213> Homo sapiens

<400> 13
Met Leu Cys Cys Met Arg Arg Thr Lys Gln Val Glu Lys Asn Asp Asp 
1               5                   10                  15      


Asp Gln Lys Ile Glu Gln Asp Gly Ile Lys Pro Glu Asp Lys Ala His 
            20                  25                  30          


Lys Ala Ala Thr Lys Ile Gln Ala Ser Phe Arg Gly His Ile Thr Arg 
        35                  40                  45              


Lys Lys Leu Lys Gly Glu Lys Lys Asp Asp Val Gln Ala Ala Glu Ala 
    50                  55                  60                  


Glu Ala Asn Lys Lys Asp Glu Ala Pro Val Ala Asp Gly Val Glu Lys 
65                  70                  75                  80  


Lys Gly Glu Gly Thr Thr Thr Ala Glu Ala Ala Pro Ala Thr Gly Ser 
                85                  90                  95      


Lys Pro Asp Glu Pro Gly Lys Ala Gly Glu Thr Pro Ser Glu Glu Lys 
            100                 105                 110         


Lys Gly Glu Gly Asp Ala Ala Thr Glu Gln Ala Ala Pro Gln Ala Pro 
        115                 120                 125             


Ala Ser Ser Glu Glu Lys Ala Gly Ser Ala Glu Thr Glu Ser Ala Thr 
    130                 135                 140                 


Lys Ala Ser Thr Asp Asn Ser Pro Ser Ser Lys Ala Glu Asp Ala Pro 
145                 150                 155                 160 


Ala Lys Glu Glu Pro Lys Gln Ala Asp Val Pro Ala Ala Val Thr Ala 
                165                 170                 175     


Ala Ala Ala Thr Thr Pro Ala Ala Glu Asp Ala Ala Ala Lys Ala Thr 
            180                 185                 190         


Ala Gln Pro Pro Thr Glu Thr Gly Glu Ser Ser Gln Ala Glu Glu Asn 
        195                 200                 205             


Ile Glu Ala Val Asp Glu Thr Lys Pro Lys Glu Ser Ala Arg Gln Asp 
    210                 215                 220                 


Glu Gly Lys Glu Glu Glu Pro Glu Ala Asp Gln Glu His Ala 
225                 230                 235             


<210> 14
<211> 3710
<212> DNA
<213> Homo sapiens

<400> 14
tctctgggtt gttttcaaca tctcaagtgt gaattttccc tgtcaaaatc ttcacaagga       60

aaatgagtca cagcatcacc tgggtgacga ggtcataaca cctcagccct tgcttaaaaa      120

attttatttc tacttttcta ttgtaaagag atctcaaaac aggaagataa aattggactg      180

acagctctac agcctagtct tttagacagt gaactaggcc agcattggca gacactggcg      240

atgacaaagt cctgctctga attatgccac cccgcactcc actttttacc ttgcctggga      300

ggcttgagga aaaatcttca gagagcagtt cgacctagtc cttattcact tggcttcttg      360

actttctgga tttcaagggt aattttacct cacatgtaac ctatacaagt attttaggtt      420

aaaaccctga ctctgccact tactagctgt atgactttga gcaaattact taattactta      480

actaatgtcc ttctacttag tcttttcatc tgtaagataa tagtacccat tgcatagttt      540

tgttcttaga attgaattag ttaatataca aactatatgc aataaatatg tttggggtgt      600

gtataatcat ataaaagtgc ttagaagagt gcttgacata tagttttaga atttgctatt      660

attatgttct ccaagcatat gagggtattt tatgtcatta cttttaaagg tcgctttttt      720

atatgtgtta gtgggaggca tttattattt ttttaagtgt gcatatccct gaaacatccc      780

tctgtggagc tataaaagaa aactataaaa tatttaccat ataattcact caatccccag      840

tctccagaaa gtaacaattt gtacttcatt tgtattgtct tcttccaggc attttacaaa      900

tactattttc tttcatcctc aaaaaaactc tgcacaatag gtaataggat tctaatatgg      960

gtgataagaa aactgaaatt tagagaaatt aagtaattta tcccaggtca tacatttaag     1020

cagtgaatga gccaggattc aaactcagat cttttgaccc caaaaccatg ccaggtagca     1080

agtaatcaat gaatgtcaat gacagatcat cgagagagaa tccagtgcca aaaatgaaga     1140

gggtgtcaac aaaataagaa caaggacaat ggcagcatga gcaacaagaa caaacttaga     1200

tccaaaatta acagttaaag atttttctag agtcctgcat atttttcctt aaactgtcca     1260

gcagcttggg gacagaaatc taattaaaat ggaagtctat gcatgctcaa accacatgcc     1320

ttgtacctga tgcaatccgc ttccacccca gtcctgaaaa aaggcattca gttatttttt     1380

tctacatgtg gaagaataca acaacatacc ttctagaatc agggagaaat gtacttgctc     1440

tttttatttt tttttaattt ctcaaatact gttctataag gataatcact cacctggtga     1500

ttaatgtaga atgttaaggt gtgtacaaat tactgctgat aggtaacact gtccttgcaa     1560

aatcatccca tgtgcccccc tcaaataaat aagtatactt caaaaagcag tgtgcttgct     1620

atacaagtgc agttttaaga aaaatcactc agctctctct tgcaaacatg ttctttcccc     1680

taatgcctcc tacacagaga ttctggagcc acccccttca gaatatctga aatatagacc     1740

aattttgctc gttaaaacta cttcaagtag tcctagagct gatattagga ttgctactta     1800

ttcagtcata cttttcgagt gttcattgtt gaattcttag attgaatttt ctattagttt     1860

ccttaaaata taagaggttg gagggctaag tttaagaccc attctactaa ttgtgaggct     1920

ttccacaatc tgtgtttcct tattttttta aaggggatgg cacacttgct tagccttctt     1980

cattatcatt ctcagaggaa tcattttaag ttgaaagtac ttcataacct ataatgcata     2040

aatttaaacc actgtcattt ccccccacca cagcccttgg caaatggggt cttaaattcc     2100

ttctcccacc aactagactt ttagcatgca ttctgacacg tattgtgtat ccttactaga     2160

tatgaggtat ataatatttg ggctttacta actatccagt gggggtgcat tggatatact     2220

tggcttggca atttcaaatt ataatgatct tcagtaccag atgctcttaa gctagtcccc     2280

tacaaatgtc tggcagcttc atttgtaact tttatcaggc ttgagtatta ccacacacaa     2340

gcacatagag tagctctcag aacctgcaga ggcaattgtt ttactagatg tgtgagggat     2400

atagttggat caatgggata gatactgtat atgaaatagt ggctaaatga gtttgtgtgt     2460

gtgtgtgtgt gtgtgtgtgt gtgtggttgg gggatgtcag gtgaaggtca catattttgg     2520

gaatgaatag atttctagtt tcagtgaatt tctatcacta agctcctaca ctaggtgaag     2580

ttttgggggg tgggtaagtt agagaagact gagaaggaat cagttggtgt gtgtcaggtg     2640

atagtagagt gggactgtgg tttaactttg acaatgtaaa cagatcttcc cccttcccaa     2700

gataagaaag aacagagttg agtactatgg cacattttac atggtttcct gcttatctct     2760

ttctttgaga atagatatag ctcagtagta ctgtcgagtt aagaaatagc ttttccaccc     2820

tctgagtgat gatacctaca atcatcagga tgaatacagt ctcatgacca aatctcctct     2880

ggtatttgtc ttatcaacat gccttaactt aatgtcacga tgctctagaa attactctga     2940

gagaataatg gtgatggcaa taattatgat gagaataatg gtagcagcca cccctttctg     3000

agtatgtaca aagtgtcagg gactgtgctg ggtgctttat gtgcattaac tcatttgatt     3060

ctcatatcag cccaatggga tagttttttt attccctcat cctgcagatg aggagcctaa     3120

agctgacttg cccaaggtca ggatctacca agtaactggc agagctggaa ttcaaactta     3180

cacatgtcta actctgcagc ccatgctctt aagcaccagg gaatattgac ttttacagga     3240

ggaggactaa gcaagggctt tgtcattcag aagctggatg acgctgggct ccttcctggt     3300

tcctcatctg tgttgattat aaaacaggca cagtgatgtg ttcctcacat gatcatgatg     3360

aggattgaat tgaaatacta aatatatata ctgtgcactt ataaatgtaa gaagagagag     3420

gaaaatgact gctggagagt ggcgtgatga aggctccagc attagtgacc tggagcgaga     3480

acacccagcc agtgagctga gtgttcacac acagagagtt tacacactct ctgagcacca     3540

acacagtatg gcatgtggtc atgcaacaac taaaaataac attttttttt agtatcaact     3600

atgtgccagc actattttag ccactgaagc ttagaagatt gtaaaaaaac agataaagtt     3660

ctgttctcag attgtttata gcccaagcga agttcagtta gtaataaaat                3710


<210> 15
<211> 330
<212> PRT
<213> Homo sapiens

<400> 15
Met Leu Pro Asp Trp Lys Ser Ser Leu Ile Leu Met Ala Tyr Ile Ile 
1               5                   10                  15      


Ile Phe Leu Thr Gly Leu Pro Ala Asn Leu Leu Ala Leu Arg Ala Phe 
            20                  25                  30          


Val Gly Arg Ile Arg Gln Pro Gln Pro Ala Pro Val His Ile Leu Leu 
        35                  40                  45              


Leu Ser Leu Thr Leu Ala Asp Leu Leu Leu Leu Leu Leu Leu Pro Phe 
    50                  55                  60                  


Lys Ile Ile Glu Ala Ala Ser Asn Phe Arg Trp Tyr Leu Pro Lys Val 
65                  70                  75                  80  


Val Cys Ala Leu Thr Ser Phe Gly Phe Tyr Ser Ser Ile Tyr Cys Ser 
                85                  90                  95      


Thr Trp Leu Leu Ala Gly Ile Ser Ile Glu Arg Tyr Leu Gly Val Ala 
            100                 105                 110         


Phe Pro Val Gln Tyr Lys Leu Ser Arg Arg Pro Leu Tyr Gly Val Ile 
        115                 120                 125             


Ala Ala Leu Val Ala Trp Val Met Ser Phe Gly His Cys Thr Ile Val 
    130                 135                 140                 


Ile Ile Val Gln Tyr Leu Asn Thr Thr Glu Gln Val Arg Ser Gly Asn 
145                 150                 155                 160 


Glu Ile Thr Cys Tyr Glu Asn Phe Thr Asp Asn Gln Leu Asp Val Val 
                165                 170                 175     


Leu Pro Val Arg Leu Glu Leu Cys Leu Val Leu Phe Phe Ile Pro Met 
            180                 185                 190         


Ala Val Thr Ile Phe Cys Tyr Trp Arg Phe Val Trp Ile Met Leu Ser 
        195                 200                 205             


Gln Pro Leu Val Gly Ala Gln Arg Arg Arg Arg Ala Val Gly Leu Ala 
    210                 215                 220                 


Val Val Thr Leu Leu Asn Phe Leu Val Cys Phe Gly Pro Tyr Asn Val 
225                 230                 235                 240 


Ser His Leu Val Gly Tyr His Gln Arg Lys Ser Pro Trp Trp Arg Ser 
                245                 250                 255     


Ile Ala Val Val Phe Ser Ser Leu Asn Ala Ser Leu Asp Pro Leu Leu 
            260                 265                 270         


Phe Tyr Phe Ser Ser Ser Val Val Arg Arg Ala Phe Gly Arg Gly Leu 
        275                 280                 285             


Gln Val Leu Arg Asn Gln Gly Ser Ser Leu Leu Gly Arg Arg Gly Lys 
    290                 295                 300                 


Asp Thr Ala Glu Gly Thr Asn Glu Asp Arg Gly Val Gly Gln Gly Glu 
305                 310                 315                 320 


Gly Met Pro Ser Ser Asp Phe Thr Thr Glu 
                325                 330 


<210> 16
<211> 2069
<212> DNA
<213> Homo sapiens

<400> 16
atgctgccgg actggaagag ctccttgatc ctcatggctt acatcatcat cttcctcact       60

ggcctccctg ccaacctcct ggccctgcgg gcctttgtgg ggcggatccg ccagccccag      120

cctgcacctg tgcacatcct cctgctgagc ctgacgctgg ccgacctcct cctgctgctg      180

ctgctgccct tcaagatcat cgaggctgcg tcgaacttcc gctggtacct gcccaaggtc      240

gtctgcgccc tcacgagttt tggcttctac agcagcatct actgcagcac gtggctcctg      300

gcgggcatca gcatcgagcg ctacctggga gtggctttcc ccgtgcagta caagctctcc      360

cgccggcctc tgtatggagt gattgcagct ctggtggcct gggttatgtc ctttggtcac      420

tgcaccatcg tgatcatcgt tcaatacttg aacacgactg agcaggtcag aagtggcaat      480

gaaattacct gctacgagaa cttcaccgat aaccagttgg acgtggtgct gcccgtgcgg      540

ctggagctgt gcctggtgct cttcttcatc cccatggcag tcaccatctt ctgctactgg      600

cgttttgtgt ggatcatgct ctcccagccc cttgtggggg cccagaggcg gcgccgagcc      660

gtggggctgg ctgtggtgac gctgctcaat ttcctggtgt gcttcggacc ttacaacgtg      720

tcccacctgg tggggtatca ccagagaaaa agcccctggt ggcggtcaat agccgtggtg      780

ttcagttcac tcaacgccag tctggacccc ctgctcttct atttctcttc ttcagtggtg      840

cgcagggcat ttgggagagg gctgcaggtg ctgcggaatc agggctcctc cctgttggga      900

cgcagaggca aagacacagc agaggggaca aatgaggaca ggggtgtggg tcaaggagaa      960

gggatgccaa gttcggactt cactacagag tagcagtttc cctggacctt cagaggtcgc     1020

ctgggttaca caggagctgg gaagcctggg agaggcggag caggaaggct cccatccaga     1080

ttcagaaatc cttagaccca gcccaggact gcgactttga aaaaaatgcc tttcaccagc     1140

ttggtatccc ttcctgactg aattgtccta ctcaaaggag cataagtcag agatgcacga     1200

agaagtagtt aggtatagaa gcacctgccg ggtgtggtgg ctcatgccta taatcccaga     1260

actttgggag gctgaggcag gtggatcact tgaggtcggg agattgagaa catcctggtc     1320

aacatgggaa aaccccgtct ctactaaaaa tacaaaaaaa ttagctgggc atggtggcac     1380

atgcctataa tcccagctac tctggaggct gaggcaggag aatccttgaa cccgggagtt     1440

ggaggttgca gtgagctgag atcacgccac tgcactccag cctagcgaca gagcaagact     1500

ccatttaaaa aaaaaaaaaa aaaaaaaaag aagcaccttc aggctggaga agcagcgtag     1560

ctaacacaag tccagtcctt gtgatgtggc tggtagttgg ggatggccag gctgaagcag     1620

agagtcctag agaaatctcg atacaagctt caaagcaaca cctagacact gctctagcgg     1680

ttgatcctgg agataaacca acaagagaga gatggaagag aaatactaaa tgaggtcaaa     1740

gaagactcag aaaggttctg agcctggaga tgagcaggga ggcctcaggg cttagacctt     1800

taatgatagg ggtttccctg cattggtttg acctgttgcc tttttgatgt gctctgtttg     1860

ttttcatgtg ttgtcttgtc tcccctgcta aactgggagc tgccaggggt ctgggtctta     1920

tctccttcct ccatggtacc ccacacaggc caggatgtgg tttggtaccc agcaatcaga     1980

gattggcact ccctcataca ggggaaagca acctggtcta gcaaattgaa aataaagatg     2040

ataaaactct gaaaaaaaaa aaaaaaaaa                                       2069


<210> 17
<211> 428
<212> PRT
<213> Homo sapiens

<400> 17
Met Leu Arg Thr Leu Leu Arg Arg Arg Leu Phe Ser Tyr Pro Thr Lys 
1               5                   10                  15      


Tyr Tyr Phe Met Val Leu Val Leu Ser Leu Ile Thr Phe Ser Val Leu 
            20                  25                  30          


Arg Ile His Gln Lys Pro Glu Phe Val Ser Val Arg His Leu Glu Leu 
        35                  40                  45              


Ala Gly Glu Asn Pro Ser Ser Asp Ile Asn Cys Thr Lys Val Leu Gln 
    50                  55                  60                  


Gly Asp Val Asn Glu Ile Gln Lys Val Lys Leu Glu Ile Leu Thr Val 
65                  70                  75                  80  


Lys Phe Lys Lys Arg Pro Arg Trp Thr Pro Asp Asp Tyr Ile Asn Met 
                85                  90                  95      


Thr Ser Asp Cys Ser Ser Phe Ile Lys Arg Arg Lys Tyr Ile Val Glu 
            100                 105                 110         


Pro Leu Ser Lys Glu Glu Ala Glu Phe Pro Ile Ala Tyr Ser Ile Val 
        115                 120                 125             


Val His His Lys Ile Glu Met Leu Asp Arg Leu Leu Arg Ala Ile Tyr 
    130                 135                 140                 


Met Pro Gln Asn Phe Tyr Cys Ile His Val Asp Thr Lys Ser Glu Asp 
145                 150                 155                 160 


Ser Tyr Leu Ala Ala Val Met Gly Ile Ala Ser Cys Phe Ser Asn Val 
                165                 170                 175     


Phe Val Ala Ser Arg Leu Glu Ser Val Val Tyr Ala Ser Trp Ser Arg 
            180                 185                 190         


Val Gln Ala Asp Leu Asn Cys Met Lys Asp Leu Tyr Ala Met Ser Ala 
        195                 200                 205             


Asn Trp Lys Tyr Leu Ile Asn Leu Cys Gly Met Asp Phe Pro Ile Lys 
    210                 215                 220                 


Thr Asn Leu Glu Ile Val Arg Lys Leu Lys Leu Leu Met Gly Glu Asn 
225                 230                 235                 240 


Asn Leu Glu Thr Glu Arg Met Pro Ser His Lys Glu Glu Arg Trp Lys 
                245                 250                 255     


Lys Arg Tyr Glu Val Val Asn Gly Lys Leu Thr Asn Thr Gly Thr Val 
            260                 265                 270         


Lys Met Leu Pro Pro Leu Glu Thr Pro Leu Phe Ser Gly Ser Ala Tyr 
        275                 280                 285             


Phe Val Val Ser Arg Glu Tyr Val Gly Tyr Val Leu Gln Asn Glu Lys 
    290                 295                 300                 


Ile Gln Lys Leu Met Glu Trp Ala Gln Asp Thr Tyr Ser Pro Asp Glu 
305                 310                 315                 320 


Tyr Leu Trp Ala Thr Ile Gln Arg Ile Pro Glu Val Pro Gly Ser Leu 
                325                 330                 335     


Pro Ala Ser His Lys Tyr Asp Leu Ser Asp Met Gln Ala Val Ala Arg 
            340                 345                 350         


Phe Val Lys Trp Gln Tyr Phe Glu Gly Asp Val Ser Lys Gly Ala Pro 
        355                 360                 365             


Tyr Pro Pro Cys Asp Gly Val His Val Arg Ser Val Cys Ile Phe Gly 
    370                 375                 380                 


Ala Gly Asp Leu Asn Trp Met Leu Arg Lys His His Leu Phe Ala Asn 
385                 390                 395                 400 


Lys Phe Asp Val Asp Val Asp Leu Phe Ala Ile Gln Cys Leu Asp Glu 
                405                 410                 415     


His Leu Arg His Lys Ala Leu Glu Thr Leu Lys His 
            420                 425             


<210> 18
<211> 5984
<212> DNA
<213> Homo sapiens

<400> 18
acagaccata ggtgaactgt taaggaggga gaagccgcag tgtcaccttc cacagtcctg       60

ctcccattaa gacctatgaa gtggaaaatg cagattattc tttgaggttt cctgggacca      120

gaaaaggtca gagactctta atgggtaatg cagacaactg gaatgcaatc atcaggtatt      180

catttctgtt ttaaggtttt atgtctgaga aacctgaaac ctgaagaagt aaagcaatca      240

tgatttttta aaaacttaat aatatggttt tggatttaaa aagaaagact gactcagagc      300

tggggaaaac actcacttgt gatacggatc aatgtgaaaa cagcttaact ctgttccatg      360

gcaattcgca cagtgtgact cagagacacc tctcttcacc agctctggct caggggatgt      420

gaagccagaa gcagaggtca cagtgacttc atctgagaag gacttaactg accattgctg      480

gttttgaagc cggaggaagg cccacagtca atgaatgaga gaggcttcga gaagctagaa      540

atggcaagga aatagatttt cctctaaagc tcccagaaag aaacacggtt ctgctgacac      600

ctcgatttta ggccagtgag acctgcttca gacttctgac ctacagaacg atttctttaa      660

agactcgtgc agcacatcat tatcgctgga tgcccggaca tgtaatacac ctgacagcat      720

gtgaagtgct cagaatgggg caggatgtca cctggaatca gcactaagtg attcagactt      780

tccttacttt taaatgtgct gctcttcatt tcaagatgcc gttgcagctc tgataaatgc      840

aaactgacaa ccttcaaggc cacgacggag ggaaaatcat tggtgcttgg agcatagaag      900

actgcccttc acaaaggaaa tccctgatta ttgtttgaaa tgctgaggac gttgctgcga      960

aggagacttt tttcttatcc caccaaatac tactttatgg ttcttgtttt atccctaatc     1020

accttctccg ttttaaggat tcatcaaaag cctgaatttg taagtgtcag acacttggag     1080

cttgctgggg agaatcctag tagtgatatt aattgcacca aagttttaca gggtgatgta     1140

aatgaaatcc aaaaggtaaa gcttgagatc ctaacagtga aatttaaaaa gcgccctcgg     1200

tggacacctg acgactatat aaacatgacc agtgactgtt cttctttcat caagagacgc     1260

aaatatattg tagaacccct tagtaaagaa gaggcggagt ttccaatagc atattctata     1320

gtggttcatc acaagattga aatgcttgac aggctgctga gggccatcta tatgcctcag     1380

aatttctatt gcattcatgt ggacacaaaa tccgaggatt cctatttagc tgcagtgatg     1440

ggcatcgctt cctgttttag taatgtcttt gtggccagcc gattggagag tgtggtttat     1500

gcatcgtgga gccgggttca ggctgacctc aactgcatga aggatctcta tgcaatgagt     1560

gcaaactgga agtacttgat aaatctttgt ggtatggatt ttcccattaa aaccaaccta     1620

gaaattgtca ggaagctcaa gttgttaatg ggagaaaaca acctggaaac ggagaggatg     1680

ccatcccata aagaagaaag gtggaagaag cggtatgagg tcgttaatgg aaagctgaca     1740

aacacaggga ctgtcaaaat gcttcctcca ctcgaaacac ctctcttttc tggcagtgcc     1800

tacttcgtgg tcagtaggga gtatgtgggg tatgtactac agaatgaaaa aatccaaaag     1860

ttgatggagt gggcacaaga cacatacagc cctgatgagt atctctgggc caccatccaa     1920

aggattcctg aagtcccggg ctcactccct gccagccata agtatgatct gtctgacatg     1980

caagcagttg ccaggtttgt caagtggcag tactttgagg gtgatgtttc caagggtgct     2040

ccctacccgc cctgcgatgg agtccatgtg cgctcagtgt gcattttcgg agctggtgac     2100

ttgaactgga tgctgcgcaa acaccacttg tttgccaata agtttgacgt ggatgttgac     2160

ctctttgcca tccagtgttt ggatgagcat ttgagacaca aagctttgga gacattaaaa     2220

cactgaccat tacgggcaat tttatgaaca agaagaagga tacacaaaac gtacccttat     2280

ctgtttcccc ttccttgtca gcatcgggaa gatggtatga agtcctcttt ggggcaggga     2340

ctctagtaga tcttcttgtc agagaagctg catggtttct gcagagcaca gttagctaga     2400

aaggtgatag cattaaatgt tcatctagag ttaatagtgg gaggagtaaa ggtagccttg     2460

aggccagagc aggtagcaag gcattgtgga aagaggggac cagggtggct ggggaagagg     2520

ccgatgcata aagtcagcct gttcaaagtg ctcagggact tagcaaaatg agaagatgtg     2580

acctgtgcca aaactatttt gagaatttta aatgtgacca tttttctggt atgaataaac     2640

ttacagcaac aaataatcaa agatacaatt aatctgatat tatatttgtt gaaatagaaa     2700

tttgattgta ctataaatga tttttgtaaa taatttatat tctgctctaa tactgtactg     2760

tgtagtgtgt ctccgtatgt catctcaggg agcttaaaat gggcttgatt taacattgtt     2820

tttgtgttat ttttgcttga aacaacgcac acattttcaa caaccaaaaa atgacaattt     2880

ctagtttagt taatttctac aaatcatctt atgttattag caaggttaag acatcttttt     2940

taaaaaaatt atagcttcta ccaagagaaa cactcaattt ttctagagat ttgcctctat     3000

cttcctttcc tcagtcttcc cagactgcta tcaagctgtg taaaaattta ctttcactgg     3060

accctaaatt attgtctctg ctatctgact gccagtaatt agtgcagaaa actaagacag     3120

gatgatacag gtttgagggg ctggggagtg ggagggggga gaaaaggaat gtatttaaac     3180

aatttccgat gcccatgatg agtttaaaaa ccagcattga caccatcccc aaaattaagg     3240

ctgtcgctta ttgaatccac ttgtgtccaa cctcccagga ttgttttatc ctaatgtcac     3300

ctgtatattc atttgaaagg acttggccct gttcttgggt cttcccgtta cctgccccct     3360

gggtggtaag tttcctcctt tctcaacctt ccacgaggag gaaagaagtg tgcagtcatt     3420

ccacatggcc tgttggaagg cctggggagg gaactttggg tttgggacag attttttttt     3480

ttgtttttgg tatcattcac agcatacgat ttttactctc tccatcttca ccataagaca     3540

gataatttgg ggttgctata atgctgtcac acatctcaaa gtacattcaa atcttaaaaa     3600

gaaattctcg tacttttgcc atgttgatac tgttcagcaa acaagctacc aggaactgtg     3660

aggctttgtc atttagcatt agactttaaa caagaattaa aatcatgtgc tgtattttta     3720

aaatctagcc aaattaaata gtacatgaga aattcagagt attagacagt tttaaggcat     3780

tcaactgaga aaactttatt tgtcaaagtc agaaaacatt ttcatcttat tgagagatat     3840

gtttttaaac ttttatcatc atttgtaaat gtggaagttg gtggattgct gtgtttttgc     3900

atgattagca tgggagtctg ttggagcaag aggaacatgc ttgttttgaa aactcgagat     3960

gatgagggtg gtacatgcag tgtgttctct ctttattggc ttctaaacca gttttgtcct     4020

ttaatgcatg tcaaatattt ctcccatgct tctcttagca gaaaagtttt tacctataag     4080

acagggcacc ttttaactct aaaactagtg atactcagtg acatagactt tgtcttataa     4140

acattttttc attttttatt ttgaaaaatt gcaaatctac agcaaaagta aaacagtaga     4200

gtgaacacca tgtaaccctc acctggtgtt aacattgtac cctatttgct ttaagttgta     4260

tgtatttctg aacttggcaa aattggaaat taaaattttt aaaaattaca aatatacaaa     4320

gttatttatc ttagcacatt tattatgtgt gactgcatct gatttatatt taaattggca     4380

ggttttgagg gatttttttc ttcatcataa atgtaaacat aggattttag agtctatttc     4440

cccaagcgcc acattataac tgtaaactta ccatcttcta tgtagctgtg atatctcatc     4500

tttctaaaat ggaacttgtt aaaaagtgtt caaacactat ccctaatgcc tgcggcagaa     4560

tttatatacg atccattcat tggggctcaa agtatctttt agacttttaa ggacaattta     4620

cagcaaatga aatttatgat gctgtgacaa gaaatttaaa gaatcaaaac gatggtttga     4680

aaaggaaacc tatgatacat gcaggagaag caaaacccaa gtgattggtg agaaatatag     4740

aaattattta aattacttta tagtaattat taaacactaa tttttgtact gtcattgaag     4800

gtgttttata gagaaatctg agaaatcaca ttcacaaatt agaagtcaaa catggccagg     4860

cacagtggct cacacctgta atcttcagga tttcaagacc agcctagcca acatgacgaa     4920

accccatctc tactgaaaat agaaaaaaaa aattagccag gcttgcacct gtaatcccag     4980

ttacctggga ggctgaggca ggagaatctc ttgagcccag gaggcggagg ttgcagtgag     5040

ctgagatgcc accaccacac cagcctgggt gacagagtga aactcgtatc tccaaacaaa     5100

caaacaaaaa gtccttaaac atatgtgaac aaaaattttg tgatggaagg attctagtta     5160

atgagtattg catcaagatt tacatctttc ttactaagga aaagagttaa taaaaattgt     5220

tctttatttt acaggcagtt actgaggctc ttcccagatc tcagtaaaca gccactcagc     5280

cttgaaaatg gagtgttgtt gtttctaaac atatatttat gtcatttatt aagtacagtt     5340

cacttaaata acataagtag attttctctt gtagtgattt gggtaggaag aggccatgtt     5400

tcagttcgtt ttctctgtag ggtcgattga attggacctt ttcagttgtt cagaaaaata     5460

aaaataattt ctcatattaa atacagacgc tcctcaactt atgatgtggg taggtcccag     5520

taaacccatt ataatttgaa aatatcacat tgaaaatgca tttaatatct cttacctgaa     5580

atcataactt agccaagcct accttaaatg ttctcagaac atttagcctg cagttgggca     5640

aaaccattta acacaaagcc tattttataa tgaagtgttg aatagctcat gttatttact     5700

gaatactgtt gtgaaagtga aaaacaatga ttgtatgggt actcaaagta taatttctac     5760

tgaatgcata tcacttgtgc actgttgtaa agctgaaaaa ccgttaagcc tctacgattt     5820

ttaagtaagt tggggaccat cagtttaaaa taaatgcaat actatttcat gataaacatg     5880

gtcactgtaa gttttactct tttgaatgag ggtgcgacag aatgcagtta gaatcagttc     5940

atatcaccat taaaatcatc cattcagaaa ccaaaaaaaa aaaa                      5984


<210> 19
<211> 667
<212> PRT
<213> Homo sapiens

<400> 19
Met Lys Glu Lys Ser Lys Asn Ala Ala Lys Thr Arg Arg Glu Lys Glu 
1               5                   10                  15      


Asn Gly Glu Phe Tyr Glu Leu Ala Lys Leu Leu Pro Leu Pro Ser Ala 
            20                  25                  30          


Ile Thr Ser Gln Leu Asp Lys Ala Ser Ile Ile Arg Leu Thr Thr Ser 
        35                  40                  45              


Tyr Leu Lys Met Arg Ala Val Phe Pro Glu Gly Leu Gly Asp Ala Trp 
    50                  55                  60                  


Gly Gln Pro Ser Arg Ala Gly Pro Leu Asp Gly Val Ala Lys Glu Leu 
65                  70                  75                  80  


Gly Ser His Leu Leu Gln Thr Leu Asp Gly Phe Val Phe Val Val Ala 
                85                  90                  95      


Ser Asp Gly Lys Ile Met Tyr Ile Ser Glu Thr Ala Ser Val His Leu 
            100                 105                 110         


Gly Leu Ser Gln Val Glu Leu Thr Gly Asn Ser Ile Tyr Glu Tyr Ile 
        115                 120                 125             


His Pro Ser Asp His Asp Glu Met Thr Ala Val Leu Thr Ala His Gln 
    130                 135                 140                 


Pro Leu His His His Leu Leu Gln Glu Tyr Glu Ile Glu Arg Ser Phe 
145                 150                 155                 160 


Phe Leu Arg Met Lys Cys Val Leu Ala Lys Arg Asn Ala Gly Leu Thr 
                165                 170                 175     


Cys Ser Gly Tyr Lys Val Ile His Cys Ser Gly Tyr Leu Lys Ile Arg 
            180                 185                 190         


Gln Tyr Met Leu Asp Met Ser Leu Tyr Asp Ser Cys Tyr Gln Ile Val 
        195                 200                 205             


Gly Leu Val Ala Val Gly Gln Ser Leu Pro Pro Ser Ala Ile Thr Glu 
    210                 215                 220                 


Ile Lys Leu Tyr Ser Asn Met Phe Met Phe Arg Ala Ser Leu Asp Leu 
225                 230                 235                 240 


Lys Leu Ile Phe Leu Asp Ser Arg Val Thr Glu Val Thr Gly Tyr Glu 
                245                 250                 255     


Pro Gln Asp Leu Ile Glu Lys Thr Leu Tyr His His Val His Gly Cys 
            260                 265                 270         


Asp Val Phe His Leu Arg Tyr Ala His His Leu Leu Leu Val Lys Gly 
        275                 280                 285             


Gln Val Thr Thr Lys Tyr Tyr Arg Leu Leu Ser Lys Arg Gly Gly Trp 
    290                 295                 300                 


Val Trp Val Gln Ser Tyr Ala Thr Val Val His Asn Ser Arg Ser Ser 
305                 310                 315                 320 


Arg Pro His Cys Ile Val Ser Val Asn Tyr Val Leu Thr Glu Ile Glu 
                325                 330                 335     


Tyr Lys Glu Leu Gln Leu Ser Leu Glu Gln Val Ser Thr Ala Lys Ser 
            340                 345                 350         


Gln Asp Ser Trp Arg Thr Ala Leu Ser Thr Ser Gln Glu Thr Arg Lys 
        355                 360                 365             


Leu Val Lys Pro Lys Asn Thr Lys Met Lys Thr Lys Leu Arg Thr Asn 
    370                 375                 380                 


Pro Tyr Pro Pro Gln Gln Tyr Ser Ser Phe Gln Met Asp Lys Leu Glu 
385                 390                 395                 400 


Cys Gly Gln Leu Gly Asn Trp Arg Ala Ser Pro Pro Ala Ser Ala Ala 
                405                 410                 415     


Ala Pro Pro Glu Leu Gln Pro His Ser Glu Ser Ser Asp Leu Leu Tyr 
            420                 425                 430         


Thr Pro Ser Tyr Ser Leu Pro Phe Ser Tyr His Tyr Gly His Phe Pro 
        435                 440                 445             


Leu Asp Ser His Val Phe Ser Ser Lys Lys Pro Met Leu Pro Ala Lys 
    450                 455                 460                 


Phe Gly Gln Pro Gln Gly Ser Pro Cys Glu Val Ala Arg Phe Phe Leu 
465                 470                 475                 480 


Ser Thr Leu Pro Ala Ser Gly Glu Cys Gln Trp His Tyr Ala Asn Pro 
                485                 490                 495     


Leu Val Pro Ser Ser Ser Ser Pro Ala Lys Asn Pro Pro Glu Pro Pro 
            500                 505                 510         


Ala Asn Thr Ala Arg His Ser Leu Val Pro Ser Tyr Glu Ala Pro Ala 
        515                 520                 525             


Ala Ala Val Arg Arg Phe Gly Glu Asp Thr Ala Pro Pro Ser Phe Pro 
    530                 535                 540                 


Ser Cys Gly His Tyr Arg Glu Glu Pro Ala Leu Gly Pro Ala Lys Ala 
545                 550                 555                 560 


Ala Arg Gln Ala Ala Arg Asp Gly Ala Arg Leu Ala Leu Ala Arg Ala 
                565                 570                 575     


Ala Pro Glu Cys Cys Ala Pro Pro Thr Pro Glu Ala Pro Gly Ala Pro 
            580                 585                 590         


Ala Gln Leu Pro Phe Val Leu Leu Asn Tyr His Arg Val Leu Ala Arg 
        595                 600                 605             


Arg Gly Pro Leu Gly Gly Ala Ala Pro Ala Ala Ser Gly Leu Ala Cys 
    610                 615                 620                 


Ala Pro Gly Gly Pro Glu Ala Ala Thr Gly Ala Leu Arg Leu Arg His 
625                 630                 635                 640 


Pro Ser Pro Ala Ala Thr Ser Pro Pro Gly Ala Pro Leu Pro His Tyr 
                645                 650                 655     


Leu Gly Ala Ser Val Ile Ile Thr Asn Gly Arg 
            660                 665         


<210> 20
<211> 4177
<212> DNA
<213> Homo sapiens

<400> 20
ggggctccgc gggcctggag cacggccggg tctaatatgc ccggagccga ggcgcgatga       60

aggagaagtc caagaatgcg gccaagacca ggagggagaa ggaaaatggc gagttttacg      120

agcttgccaa gctgctcccg ctgccgtcgg ccatcacttc gcagctggac aaagcgtcca      180

tcatccgcct caccacgagc tacctgaaga tgcgcgccgt cttccccgaa ggtttaggag      240

acgcgtgggg acagccgagc cgcgccgggc ccctggacgg cgtcgccaag gagctgggat      300

cgcacttgct gcagactttg gatggatttg tttttgtggt agcatctgat ggcaaaatca      360

tgtatatatc cgagaccgct tctgtccatt taggcttatc ccaggtggag ctcacgggca      420

acagtattta tgaatacatc catccttctg accacgatga gatgaccgct gtcctcacgg      480

cccaccagcc gctgcaccac cacctgctcc aagagtatga gatagagagg tcgttctttc      540

ttcgaatgaa atgtgtcttg gcgaaaagga acgcgggcct gacctgcagc ggatacaagg      600

tcatccactg cagtggctac ttgaagatca ggcagtatat gctggacatg tccctgtacg      660

actcctgcta ccagattgtg gggctggtgg ccgtgggcca gtcgctgcca cccagtgcca      720

tcaccgagat caagctgtac agtaacatgt tcatgttcag ggccagcctt gacctgaagc      780

tgatattcct ggattccagg gtgaccgagg tgacggggta cgagccgcag gacctgatcg      840

agaagaccct ataccatcac gtgcacggct gcgacgtgtt ccacctccgc tacgcacacc      900

acctcctgtt ggtgaagggc caggtcacca ccaagtacta ccggctgctg tccaagcggg      960

gcggctgggt gtgggtgcag agctacgcca ccgtggtgca caacagccgc tcgtcccggc     1020

cccactgcat cgtgagtgtc aattatgtac tcacggagat tgaatacaag gaacttcagc     1080

tgtccctgga gcaggtgtcc actgccaagt cccaggactc ctggaggacc gccttgtcta     1140

cctcacaaga aactaggaaa ttagtgaaac ccaaaaatac caagatgaag acaaagctga     1200

gaacaaaccc ttacccccca cagcaataca gctcgttcca aatggacaaa ctggaatgcg     1260

gccagctcgg aaactggaga gccagtcccc ctgcaagcgc tgctgctcct ccagaactgc     1320

agccccactc agaaagcagt gaccttctgt acacgccatc ctacagcctg cccttctcct     1380

accattacgg acacttccct ctggactctc acgtcttcag cagcaaaaag ccaatgttgc     1440

cggccaagtt cgggcagccc caaggatccc cttgtgaggt ggcacgcttt ttcctgagca     1500

cactgccagc cagcggtgaa tgccagtggc attatgccaa ccccctagtg cctagcagct     1560

cgtctccagc taaaaatcct ccagagccac cggcgaacac tgctaggcac agcctggtgc     1620

caagctacga agcgcccgcc gccgccgtgc gcaggttcgg cgaggacacc gcgcccccga     1680

gcttcccgag ctgcggccac taccgcgagg agcccgcgct gggcccggcc aaagccgccc     1740

gccaggccgc ccgggacggg gcgcggctgg cgctggcccg cgcggcaccc gagtgctgcg     1800

cgcccccgac ccccgaggcc ccgggcgcgc cggcgcagct gcccttcgtg ctgctcaact     1860

accaccgcgt gctggcccgg cgcggaccgc tggggggcgc cgcacccgcc gcctccggcc     1920

tggcctgcgc tcccggcggc cccgaggcgg cgaccggcgc gctgcggctc cggcacccga     1980

gccccgccgc cacctccccg cccggcgcgc ccctgccgca ctacctgggc gcctcggtca     2040

tcatcaccaa cgggaggtga cccgctggcc gcccgcgcca ggagcctgga cccggcctcc     2100

cggggctgcg gcgccaccga gcccggcaaa tgcgcacgac ctacattaat ttatgcagag     2160

acagctgttt gaattggacc ccgccgccga cttgcggatt tccaccgcgg aggccccgcg     2220

cgccggtgcc gagggccgag gagcgcccgg gtccgggcag gtgaccgccc gcctctgtcc     2280

tgcgagggcc ggtgcgaccc agttgctggg ggcttggttt cctcaccttg aaatcgggct     2340

tcacgcgtct tgccttgtcc ccaacgttcc acaacagtcc cgctggggga ttgaagcggt     2400

ttcactccgc aaatatcctc cactttcagg agggaaaacc caccctacca cagtccgctc     2460

ttccaagtgg acggcagacc tgggagggga cgcctgtgtc acgagccctt ttagatgctt     2520

aggtgaaggc agaagtgatg attgtaagtc ccatgaatac acaactccac tgtctttaaa     2580

agtcattcaa gagtctcatt atttttgttt ttatttaacc ctttcttcaa tacaaaaagc     2640

caacaaacca agactaaggg ggtgaccatg caattccatt ttgtgtctgt gaacataggt     2700

gtgcttccca aatacattaa caagctctta cttcccccta acccctatga actcttgata     2760

acaccaagag tagcaccttc agaatatatt gaataggcat taaatgcaaa aatatatatg     2820

tagccagaca gtttatgaga atgaccctgt caagcttcat tattacgtgg caaaatccct     2880

ctggcccaca cagatctgta attcactagg ctcgtgtttg ctacaaatag tgctaataaa     2940

gttaaattgc acgtgcaata cggaacactg tcaatggact gcaccttgtg aaggaaaaac     3000

atgcttaagg gggtgtaatg aaaatgatgt agacatttta agcattttct acacagcgag     3060

aaaacttcgt aagaacatgt tacgtgtgca acaggtaaac agaaatcctt tcataaagca     3120

ccagcagtgt ttaaaaaatg agcttccatt aatttttact ttttatgggt tttgcttaaa     3180

gatctcaaca tggaaaaatc ctgtcatggc tctgaactgc acaatgcatt gaaccgccgt     3240

ccttcaattt tcttcacact atcaacactg cagcattttg ctgctttatc aaaatggttt     3300

attttaggaa actttttcca cctttctgaa tggaaagagg ttttcacaaa tgttttaaac     3360

tcatcgttct aaaatcaagt gcacctacac caactgctct caaaatgtga actgactttt     3420

tttttttttt ttttgccaac cctgtgtcac ttagtgagga cctgacacaa tccctacagg     3480

gtgtctgtca gtgggcctca tggtaagagt cacaatttgc aaatttagga ccgtgggtca     3540

tgcagcgaag gggctggatg gtaggaaggg atgtgcccgc ctctccacgc actcagctat     3600

acctcattca cagctccttg tgagtgtgtg cacaggaaat aagccgaggg tattattttt     3660

ttatgttcat gagtcttgta attaaaccgt gattcttgaa aggtgtaggt ttgattacta     3720

ggagatacca ccgacatttt tcaataaagt actgcaaaat gcttttgtgt ctaccttgtt     3780

attaactttt ggggctgtat ttagtaaaaa taaatcaagg ctatcggagc agttcaataa     3840

caaaggttac tgttgagaaa aaagacccta tcatagattt acaagtgaca acgtggacag     3900

gcgtaacaga gtgtgtatgt acttgaaaat gtgtactagt gaaaacgtcc ttgtctaaac     3960

aaacttcgtt ttcataacct agaacatgaa ggaagattct tacacgagct ggcttcagga     4020

cggccagggc tgagtgtgaa gtcagcagag ctgttactgt ggcaacctaa tattgtgacc     4080

tccatcttga agagtctgca catttaagct ggggatagcg tttcttgact tctgtgaggc     4140

tccggcaggg gaagaggaag cattttaata catatgc                              4177


<210> 21
<211> 294
<212> PRT
<213> Homo sapiens

<400> 21
Met Lys Asp Arg Leu Gln Glu Leu Lys Gln Arg Thr Lys Glu Ile Glu 
1               5                   10                  15      


Leu Ser Arg Asp Ser His Val Ser Thr Thr Glu Thr Glu Glu Gln Gly 
            20                  25                  30          


Val Phe Leu Gln Gln Ala Val Ile Tyr Glu Arg Glu Pro Val Ala Glu 
        35                  40                  45              


Arg His Leu His Glu Ile Gln Lys Leu Gln Glu Ser Ile Asn Asn Leu 
    50                  55                  60                  


Ala Asp Asn Val Gln Lys Phe Gly Gln Gln Gln Lys Ser Leu Val Ala 
65                  70                  75                  80  


Ser Met Arg Arg Phe Ser Leu Leu Lys Arg Glu Ser Thr Ile Thr Lys 
                85                  90                  95      


Glu Ile Lys Ile Gln Ala Glu Tyr Ile Asn Arg Ser Leu Asn Asp Leu 
            100                 105                 110         


Val Lys Glu Val Lys Lys Ser Glu Val Glu Asn Gly Pro Ser Ser Val 
        115                 120                 125             


Val Thr Arg Ile Leu Lys Ser Gln His Ala Ala Met Phe Arg His Phe 
    130                 135                 140                 


Gln Gln Ile Met Phe Ile Tyr Asn Asp Thr Ile Ala Ala Lys Gln Glu 
145                 150                 155                 160 


Lys Cys Lys Thr Phe Ile Leu Arg Gln Leu Glu Val Ala Gly Lys Glu 
                165                 170                 175     


Met Ser Glu Glu Asp Val Asn Asp Met Leu His Gln Gly Lys Trp Glu 
            180                 185                 190         


Val Phe Asn Glu Ser Leu Leu Thr Glu Ile Asn Ile Thr Lys Ala Gln 
        195                 200                 205             


Leu Ser Glu Ile Glu Gln Arg His Lys Glu Leu Val Asn Leu Glu Asn 
    210                 215                 220                 


Gln Ile Lys Asp Leu Arg Asp Leu Phe Ile Gln Ile Ser Leu Leu Val 
225                 230                 235                 240 


Glu Glu Gln Gly Glu Ser Ile Asn Asn Ile Glu Met Thr Val Asn Ser 
                245                 250                 255     


Thr Lys Glu Tyr Val Asn Asn Thr Lys Glu Lys Phe Gly Leu Ala Val 
            260                 265                 270         


Lys Tyr Lys Lys Arg Asn Pro Cys Arg Val Leu Cys Cys Trp Cys Cys 
        275                 280                 285             


Pro Cys Cys Ser Ser Lys 
    290                 


<210> 22
<211> 1198
<212> DNA
<213> Homo sapiens

<400> 22
gtgtgaagta agcaatctat tttcacttgc tattaacagc aaacgtacaa ctttatctct       60

tatttgactt cattatttgg ctttcaaatt aacaacatga aaactataca gaaattagtc      120

tgtgccctat aagacagaga tttagataat ttgttcaaaa catgagatga tattcagata      180

ttctctcaaa ggcaggactc caacaccgca ggtggaaaac caacaaaagg aagaaaacag      240

aaaggaggaa agggaagatg aaagaccgac ttcaagaact aaagcagaga acaaaggaaa      300

ttgaactctc tagagacagt catgtatcaa ctacagaaac agaggaacaa ggggtgtttc      360

tacagcaagc tgttatttat gaaagagagc ctgtagctga gagacaccta catgaaatcc      420

aaaaactaca ggaaagtatt aacaatttgg cagataatgt tcaaaaattt gggcagcaac      480

agaaaagtct ggtggcttca atgagaaggt ttagtctact taagagagag tctaccatta      540

caaaggagat aaaaattcag gcagaataca tcaacagaag tttgaatgat ttagttaaag      600

aagttaaaaa gtcagaggtt gaaaatggtc catcttcagt ggtcacaagg atacttaaat      660

ctcagcatgc tgcaatgttc cgccattttc agcaaatcat gtttatatac aatgacacaa      720

tagcagcaaa gcaagagaag tgcaagacat ttattttacg tcagcttgaa gttgctggaa      780

aagagatgtc tgaagaagat gtaaatgata tgcttcatca aggaaaatgg gaagttttta      840

atgaaagctt acttacagaa atcaatatca ctaaagcaca actttcagag attgaacaga      900

gacacaagga acttgttaat ttggagaacc aaataaagga tttaagggat cttttcattc      960

agatatctct tttagtagag gaacaaggag agagcatcaa caatattgaa atgacagtga     1020

atagtacaaa agagtatgtt aacaatacta aagagaaatt tggactagct gtaaaataca     1080

aaaaaagaaa tccttgcaga gtactgtgtt gttggtgctg tccatgctgt agctcaaaat     1140

aaagaagcta ttttaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa       1198


<210> 23
<211> 1044
<212> PRT
<213> Homo sapiens

<400> 23
Met Lys Pro Gly Cys Ala Ala Gly Ser Pro Gly Asn Glu Trp Ile Phe 
1               5                   10                  15      


Phe Ser Thr Asp Glu Ile Thr Thr Arg Tyr Arg Asn Thr Met Ser Asn 
            20                  25                  30          


Gly Gly Leu Gln Arg Ser Val Ile Leu Ser Ala Leu Ile Leu Leu Arg 
        35                  40                  45              


Ala Val Thr Gly Phe Ser Gly Asp Gly Arg Ala Ile Trp Ser Lys Asn 
    50                  55                  60                  


Pro Asn Phe Thr Pro Val Asn Glu Ser Gln Leu Phe Leu Tyr Asp Thr 
65                  70                  75                  80  


Phe Pro Lys Asn Phe Phe Trp Gly Ile Gly Thr Gly Ala Leu Gln Val 
                85                  90                  95      


Glu Gly Ser Trp Lys Lys Asp Gly Lys Gly Pro Ser Ile Trp Asp His 
            100                 105                 110         


Phe Ile His Thr His Leu Lys Asn Val Ser Ser Thr Asn Gly Ser Ser 
        115                 120                 125             


Asp Ser Tyr Ile Phe Leu Glu Lys Asp Leu Ser Ala Leu Asp Phe Ile 
    130                 135                 140                 


Gly Val Ser Phe Tyr Gln Phe Ser Ile Ser Trp Pro Arg Leu Phe Pro 
145                 150                 155                 160 


Asp Gly Ile Val Thr Val Ala Asn Ala Lys Gly Leu Gln Tyr Tyr Ser 
                165                 170                 175     


Thr Leu Leu Asp Ala Leu Val Leu Arg Asn Ile Glu Pro Ile Val Thr 
            180                 185                 190         


Leu Tyr His Trp Asp Leu Pro Leu Ala Leu Gln Glu Lys Tyr Gly Gly 
        195                 200                 205             


Trp Lys Asn Asp Thr Ile Ile Asp Ile Phe Asn Asp Tyr Ala Thr Tyr 
    210                 215                 220                 


Cys Phe Gln Met Phe Gly Asp Arg Val Lys Tyr Trp Ile Thr Ile His 
225                 230                 235                 240 


Asn Pro Tyr Leu Val Ala Trp His Gly Tyr Gly Thr Gly Met His Ala 
                245                 250                 255     


Pro Gly Glu Lys Gly Asn Leu Ala Ala Val Tyr Thr Val Gly His Asn 
            260                 265                 270         


Leu Ile Lys Ala His Ser Lys Val Trp His Asn Tyr Asn Thr His Phe 
        275                 280                 285             


Arg Pro His Gln Lys Gly Trp Leu Ser Ile Thr Leu Gly Ser His Trp 
    290                 295                 300                 


Ile Glu Pro Asn Arg Ser Glu Asn Thr Met Asp Ile Phe Lys Cys Gln 
305                 310                 315                 320 


Gln Ser Met Val Ser Val Leu Gly Trp Phe Ala Asn Pro Ile His Gly 
                325                 330                 335     


Asp Gly Asp Tyr Pro Glu Gly Met Arg Lys Lys Leu Phe Ser Val Leu 
            340                 345                 350         


Pro Ile Phe Ser Glu Ala Glu Lys His Glu Met Arg Gly Thr Ala Asp 
        355                 360                 365             


Phe Phe Ala Phe Ser Phe Gly Pro Asn Asn Phe Lys Pro Leu Asn Thr 
    370                 375                 380                 


Met Ala Lys Met Gly Gln Asn Val Ser Leu Asn Leu Arg Glu Ala Leu 
385                 390                 395                 400 


Asn Trp Ile Lys Leu Glu Tyr Asn Asn Pro Arg Ile Leu Ile Ala Glu 
                405                 410                 415     


Asn Gly Trp Phe Thr Asp Ser Arg Val Lys Thr Glu Asp Thr Thr Ala 
            420                 425                 430         


Ile Tyr Met Met Lys Asn Phe Leu Ser Gln Val Leu Gln Ala Ile Arg 
        435                 440                 445             


Leu Asp Glu Ile Arg Val Phe Gly Tyr Thr Ala Trp Ser Leu Leu Asp 
    450                 455                 460                 


Gly Phe Glu Trp Gln Asp Ala Tyr Thr Ile Arg Arg Gly Leu Phe Tyr 
465                 470                 475                 480 


Val Asp Phe Asn Ser Lys Gln Lys Glu Arg Lys Pro Lys Ser Ser Ala 
                485                 490                 495     


His Tyr Tyr Lys Gln Ile Ile Arg Glu Asn Gly Phe Ser Leu Lys Glu 
            500                 505                 510         


Ser Thr Pro Asp Val Gln Gly Gln Phe Pro Cys Asp Phe Ser Trp Gly 
        515                 520                 525             


Val Thr Glu Ser Val Leu Lys Pro Glu Ser Val Ala Ser Ser Pro Gln 
    530                 535                 540                 


Phe Ser Asp Pro His Leu Tyr Val Trp Asn Ala Thr Gly Asn Arg Leu 
545                 550                 555                 560 


Leu His Arg Val Glu Gly Val Arg Leu Lys Thr Arg Pro Ala Gln Cys 
                565                 570                 575     


Thr Asp Phe Val Asn Ile Lys Lys Gln Leu Glu Met Leu Ala Arg Met 
            580                 585                 590         


Lys Val Thr His Tyr Arg Phe Ala Leu Asp Trp Ala Ser Val Leu Pro 
        595                 600                 605             


Thr Gly Asn Leu Ser Ala Val Asn Arg Gln Ala Leu Arg Tyr Tyr Arg 
    610                 615                 620                 


Cys Val Val Ser Glu Gly Leu Lys Leu Gly Ile Ser Ala Met Val Thr 
625                 630                 635                 640 


Leu Tyr Tyr Pro Thr His Ala His Leu Gly Leu Pro Glu Pro Leu Leu 
                645                 650                 655     


His Ala Asp Gly Trp Leu Asn Pro Ser Thr Ala Glu Ala Phe Gln Ala 
            660                 665                 670         


Tyr Ala Gly Leu Cys Phe Gln Glu Leu Gly Asp Leu Val Lys Leu Trp 
        675                 680                 685             


Ile Thr Ile Asn Glu Pro Asn Arg Leu Ser Asp Ile Tyr Asn Arg Ser 
    690                 695                 700                 


Gly Asn Asp Thr Tyr Gly Ala Ala His Asn Leu Leu Val Ala His Ala 
705                 710                 715                 720 


Leu Ala Trp Arg Leu Tyr Asp Arg Gln Phe Arg Pro Ser Gln Arg Gly 
                725                 730                 735     


Ala Val Ser Leu Ser Leu His Ala Asp Trp Ala Glu Pro Ala Asn Pro 
            740                 745                 750         


Tyr Ala Asp Ser His Trp Arg Ala Ala Glu Arg Phe Leu Gln Phe Glu 
        755                 760                 765             


Ile Ala Trp Phe Ala Glu Pro Leu Phe Lys Thr Gly Asp Tyr Pro Ala 
    770                 775                 780                 


Ala Met Arg Glu Tyr Ile Ala Ser Lys His Arg Arg Gly Leu Ser Ser 
785                 790                 795                 800 


Ser Ala Leu Pro Arg Leu Thr Glu Ala Glu Arg Arg Leu Leu Lys Gly 
                805                 810                 815     


Thr Val Asp Phe Cys Ala Leu Asn His Phe Thr Thr Arg Phe Val Met 
            820                 825                 830         


His Glu Gln Leu Ala Gly Ser Arg Tyr Asp Ser Asp Arg Asp Ile Gln 
        835                 840                 845             


Phe Leu Gln Asp Ile Thr Arg Leu Ser Ser Pro Thr Arg Leu Ala Val 
    850                 855                 860                 


Ile Pro Trp Gly Val Arg Lys Leu Leu Arg Trp Val Arg Arg Asn Tyr 
865                 870                 875                 880 


Gly Asp Met Asp Ile Tyr Ile Thr Ala Ser Gly Ile Asp Asp Gln Ala 
                885                 890                 895     


Leu Glu Asp Asp Arg Leu Arg Lys Tyr Tyr Leu Gly Lys Tyr Leu Gln 
            900                 905                 910         


Glu Val Leu Lys Ala Tyr Leu Ile Asp Lys Val Arg Ile Lys Gly Tyr 
        915                 920                 925             


Tyr Ala Phe Lys Leu Ala Glu Glu Lys Ser Lys Pro Arg Phe Gly Phe 
    930                 935                 940                 


Phe Thr Ser Asp Phe Lys Ala Lys Ser Ser Ile Gln Phe Tyr Asn Lys 
945                 950                 955                 960 


Val Ile Ser Ser Arg Gly Phe Pro Phe Glu Asn Ser Ser Ser Arg Cys 
                965                 970                 975     


Ser Gln Thr Gln Glu Asn Thr Glu Cys Thr Val Cys Leu Phe Leu Val 
            980                 985                 990         


Gln Lys Lys Pro Leu Ile Phe Leu  Gly Cys Cys Phe Phe  Ser Thr Leu 
        995                 1000                 1005             


Val Leu  Leu Leu Ser Ile Ala  Ile Phe Gln Arg Gln  Lys Arg Arg 
    1010                 1015                 1020             


Lys Phe  Trp Lys Ala Lys Asn  Leu Gln His Ile Pro  Leu Lys Lys 
    1025                 1030                 1035             


Gly Lys  Arg Val Val Ser 
    1040                 


<210> 24
<211> 6079
<212> DNA
<213> Homo sapiens

<400> 24
atcctcagtc tcccagttca agctaatcat tgacagagct ttacaatcac aagcttttac       60

tgaagctttg ataagacagt ccagcagttg gtggcaaatg aagccaggct gtgcggcagg      120

atctccaggg aatgaatgga ttttcttcag cactgatgaa ataaccacac gctataggaa      180

tacaatgtcc aacgggggat tgcaaagatc tgtcatcctg tcagcactta ttctgctacg      240

agctgttact ggattctctg gagatggaag agctatatgg tctaaaaatc ctaattttac      300

tccggtaaat gaaagtcagc tgtttctcta tgacactttc cctaaaaact ttttctgggg      360

tattgggact ggagcattgc aagtggaagg gagttggaag aaggatggaa aaggaccttc      420

tatatgggat catttcatcc acacacacct taaaaatgtc agcagcacga atggttccag      480

tgacagttat atttttctgg aaaaagactt atcagccctg gattttatag gagtttcttt      540

ttatcaattt tcaatttcct ggccaaggct tttccccgat ggaatagtaa cagttgccaa      600

cgcaaaaggt ctgcagtact acagtactct tctggacgct ctagtgctta gaaacattga      660

acctatagtt actttatacc actgggattt gcctttggca ctacaagaaa aatatggggg      720

gtggaaaaat gataccataa tagatatctt caatgactat gccacatact gtttccagat      780

gtttggggac cgtgtcaaat attggattac aattcacaac ccatatctag tggcttggca      840

tgggtatggg acaggtatgc atgcccctgg agagaaggga aatttagcag ctgtctacac      900

tgtgggacac aacttgatca aggctcactc gaaagtttgg cataactaca acacacattt      960

ccgcccacat cagaagggtt ggttatcgat cacgttggga tctcattgga tcgagccaaa     1020

ccggtcggaa aacacgatgg atatattcaa atgtcaacaa tccatggttt ctgtgcttgg     1080

atggtttgcc aaccctatcc atggggatgg cgactatcca gaggggatga gaaagaagtt     1140

gttctccgtt ctacccattt tctctgaagc agagaagcat gagatgagag gcacagctga     1200

tttctttgcc ttttcttttg gacccaacaa cttcaagccc ctaaacacca tggctaaaat     1260

gggacaaaat gtttcactta atttaagaga agcgctgaac tggattaaac tggaatacaa     1320

caaccctcga atcttgattg ctgagaatgg ctggttcaca gacagtcgtg tgaaaacaga     1380

agacaccacg gccatctaca tgatgaagaa tttcctcagc caggtgcttc aagcaataag     1440

gttagatgaa atacgagtgt ttggttatac tgcctggtct ctcctggatg gctttgaatg     1500

gcaggatgct tacaccatcc gccgaggatt attttatgtg gattttaaca gtaaacagaa     1560

agagcggaaa cctaagtctt cagcacacta ctacaaacag atcatacgag aaaatggttt     1620

ttctttaaaa gagtccacgc cagatgtgca gggccagttt ccctgtgact tctcctgggg     1680

tgtcactgaa tctgttctta agcccgagtc tgtggcttcg tccccacagt tcagcgatcc     1740

tcatctgtac gtgtggaacg ccactggcaa cagactgttg caccgagtgg aaggggtgag     1800

gctgaaaaca cgacccgctc aatgcacaga ttttgtaaac atcaaaaaac aacttgagat     1860

gttggcaaga atgaaagtca cccactaccg gtttgctctg gattgggcct cggtccttcc     1920

cactggcaac ctgtccgcgg tgaaccgaca ggccctgagg tactacaggt gcgtggtcag     1980

tgaggggctg aagcttggca tctccgcgat ggtcaccctg tattatccga cccacgccca     2040

cctaggcctc cccgagcctc tgttgcatgc cgacgggtgg ctgaacccat cgacggccga     2100

ggccttccag gcctacgctg ggctgtgctt ccaggagctg ggggacctgg tgaagctctg     2160

gatcaccatc aacgagccta accggctaag tgacatctac aaccgctctg gcaacgacac     2220

ctacggggcg gcgcacaacc tgctggtggc ccacgccctg gcctggcgcc tctacgaccg     2280

gcagttcagg ccctcacagc gcggggccgt gtcgctgtcg ctgcacgcgg actgggcgga     2340

acccgccaac ccctatgctg actcgcactg gagggcggcc gagcgcttcc tgcagttcga     2400

gatcgcctgg ttcgccgagc cgctcttcaa gaccggggac taccccgcgg ccatgaggga     2460

atacattgcc tccaagcacc gacgggggct ttccagctcg gccctgccgc gcctcaccga     2520

ggccgaaagg aggctgctca agggcacggt cgacttctgc gcgctcaacc acttcaccac     2580

taggttcgtg atgcacgagc agctggccgg cagccgctac gactcggaca gggacatcca     2640

gtttctgcag gacatcaccc gcctgagctc ccccacgcgc ctggctgtga ttccctgggg     2700

ggtgcgcaag ctgctgcggt gggtccggag gaactacggc gacatggaca tttacatcac     2760

cgccagtggc atcgacgacc aggctctgga ggatgaccgg ctccggaagt actacctagg     2820

gaagtacctt caggaggtgc tgaaagcata cctgattgat aaagtcagaa tcaaaggcta     2880

ttatgcattc aaactggctg aagagaaatc taaacccaga tttggattct tcacatctga     2940

ttttaaagct aaatcctcaa tacaatttta caacaaagtg atcagcagca ggggcttccc     3000

ttttgagaac agtagttcta gatgcagtca gacccaagaa aatacagagt gcactgtctg     3060

cttattcctt gtgcagaaga aaccactgat attcctgggt tgttgcttct tctccaccct     3120

ggttctactc ttatcaattg ccatttttca aaggcagaag agaagaaagt tttggaaagc     3180

aaaaaactta caacacatac cattaaagaa aggcaagaga gttgttagct aaactgatct     3240

gtctgcatga tagacagttt aaaaattcat cccagttcca tatgctggta acttacagga     3300

gatatacctg tattatagaa agacaatctg agatacagct gtaaccaagg tgatgacaat     3360

tgtctctgct gtgtggttca aagaacattc ccttaggtgt tgacatcagt gaactcagtt     3420

cttggatgta aacataaagg cttcatcctg acagtaagct atgaggatta catgctacat     3480

tgcttcttaa agtttcatca actgtattcc atcattctgc tttagctttc atctctacca     3540

atagctactt gtggtacaat aaattatttt taagaagtaa aactctgggg ctggacgctg     3600

tggctcacac ctgtaatctc agcactttgg gaggccgagg cggggagatc acctgaggtg     3660

aggagttcga gaccagcctg gccaacatgg tgaaaccatg tctctactaa aaatacaaaa     3720

aattagccag gcgtggtgac agtggcacct gtaatcccag ctacttggga ggctgaggca     3780

gaagtttgaa cccaggaaac aggttacagt aggccaaaat tgcgccactg cactccagcc     3840

taggcgacaa cagcaagact gtgtccaaaa aaaaaaaaaa aagcaaaagc aaaactttgt     3900

tttgttagac tctacagcag agatttaaca cccttcttta aactgggtag tcagtgatag     3960

ataatatata ttctgtcact tctaataagg tgccttctcc tttaggtcag ggtggttcta     4020

aaatggaaag aaaacacaat agggtaagta gtgcttgtct aagccagtta caacacagac     4080

tcttaaagag gatcaagccc ttcatttttc taacaacaaa aaatcaccta tagaatatct     4140

aatttgtgat cttttactag atctgatttt ttaaaataat gtaatttccg gccaggcacg     4200

gtggcaccgc ctgtaatccc agcactttgg gaggccaagg caggtggatc acctgaggtt     4260

aggagttcga gactagcctg gccaacatgg caaaacccca tctctactaa aaatacaaaa     4320

gttagccggg catggtggtg ggcacctgta atcccagcta ctcaggaggc cgaggcagga     4380

gaatcgcttg aacccgagag gcagaggttg caatgagcca agatcgtgcc attgcactcc     4440

agcctggggg acagggcaag actgtctctc aaaataaaaa aaaataataa aaataaaaat     4500

aaaagtaatt tccaaaacct catctcatgg aaagatcaca ggatgaagga aagctagact     4560

caactctgtg aatagaagtt gctatactgt aagtaaagca acaattcaga atactgaatg     4620

agtttaaatt gttttatata gcaccctttt gggctagggt taattactag atctgacttg     4680

gataatttga cactttggga aatgaactct gttcttgaga cttgttcagt gtattttaaa     4740

catctgagga agaaaactta aatatgcacc tatttatacc tattctttct ttaggtcaac     4800

atttaacacc cactgcatac attaatttgt ccttgtctgc tcactccagc aatttagacc     4860

ttaacagtca caagagacgt tcttctgtta caaagcctta gtaaattaag gcagttttga     4920

ttatattcta ggtccaccta tgtctgaagc taaattcagt atctaactgc taatgaacaa     4980

gtttccaaaa tactgtaaaa atacaattag tcaatttgag taaatgcaaa tatgatgaga     5040

aatcaatttg ctatttggcc tggcaaatgg gaacagtaaa attctgcttt actcttctct     5100

agtctccttg ccccagctgc acccactacc ccaaagttgg cagttttgag gtatgatttt     5160

caaggaattt ttttagtatt aacatctccc tctgagaact atgtacctaa ggtcacgcat     5220

acaactagtc aattctgttt ttattactct aactatgtag aaacagtaag tcacttaaaa     5280

caatcacttg gctgggtttt ttcccctttg tgccacattg attcaccctg acccaagaac     5340

tccagggaaa attctttaat gtcaactggg caactcatta acctctcttt aacatcaagg     5400

gcttgggaaa aaaaaaaaaa aggttagcca caggaataac aaaaacctgg aatttatctt     5460

tcaggttttg ctttctcttt ctcactttgt ttaaagtatc tcgtactcac agttcacaaa     5520

ttaaccttca ctgtctcttt cacattaaga gcttatgctt aaagcatgcc ccccttttct     5580

aacttgctgg tttaccataa actcccctaa gtaataaaat tcctaaccca gtactgagag     5640

tcctccttct ctgccacttg ggcattattt tactagtttt taagccatca tcgcacaaga     5700

atccaaaaac ccttaaattt tttaaccact ggcaaatatg tacagcaaat taggttaagc     5760

atttaatctg gctcatgctc tatcatacta aatattcagg tttatcataa actccttaaa     5820

aaccatcaaa ggtcaaccag aaactgataa ctcttgaaag gagcaaacag gtaagatctt     5880

tggagtttaa gcttttctga gatgtgttgt gaaaaatcta acgtgtttat cgtatattca     5940

atgtaacaac ctggagaatc acaactatat ttaaagagcc tctggaaaat gaggccagta     6000

cagtgtgact acatgtttaa ttttcaatgt aatttattcc aaataaactg gttcatgctg     6060

accacttgta ttcaactaa                                                  6079


<210> 25
<211> 326
<212> PRT
<213> Homo sapiens

<400> 25
Met Thr Gly Leu Cys Gly Tyr Ser Ala Pro Asp Met Arg Gly Leu Arg 
1               5                   10                  15      


Leu Ile Met Ile Pro Val Glu Leu Leu Leu Cys Tyr Leu Leu Leu His 
            20                  25                  30          


Pro Val Asp Ala Thr Ser Tyr Gly Lys Gln Thr Asn Val Leu Met His 
        35                  40                  45              


Phe Pro Leu Ser Leu Glu Ser Gln Thr Pro Ser Ser Asp Pro Leu Ser 
    50                  55                  60                  


Cys Gln Phe Leu His Pro Lys Ser Leu Pro Gly Phe Ser His Met Ala 
65                  70                  75                  80  


Pro Leu Pro Lys Phe Leu Val Ser Leu Ala Leu Arg Asn Ala Leu Glu 
                85                  90                  95      


Glu Ala Gly Cys Gln Ala Asp Val Trp Ala Leu Gln Leu Gln Leu Tyr 
            100                 105                 110         


Arg Gln Gly Gly Val Asn Ala Thr Gln Val Leu Ile Gln His Leu Arg 
        115                 120                 125             


Gly Leu Gln Lys Gly Arg Ser Thr Glu Arg Asn Val Ser Val Glu Ala 
    130                 135                 140                 


Leu Ala Ser Ala Leu Gln Leu Leu Ala Arg Glu Gln Gln Ser Thr Gly 
145                 150                 155                 160 


Arg Val Gly Arg Ser Leu Pro Thr Glu Asp Cys Glu Asn Glu Lys Glu 
                165                 170                 175     


Gln Ala Val His Asn Val Val Gln Leu Leu Pro Gly Val Gly Thr Phe 
            180                 185                 190         


Tyr Asn Leu Gly Thr Ala Leu Tyr Tyr Ala Thr Gln Asn Cys Leu Gly 
        195                 200                 205             


Lys Ala Arg Glu Arg Gly Arg Asp Gly Ala Ile Asp Leu Gly Tyr Asp 
    210                 215                 220                 


Leu Leu Met Thr Met Ala Gly Met Ser Gly Gly Pro Met Gly Leu Ala 
225                 230                 235                 240 


Ile Ser Ala Ala Leu Lys Pro Ala Leu Arg Ser Gly Val Gln Gln Leu 
                245                 250                 255     


Ile Gln Tyr Tyr Gln Asp Gln Lys Asp Ala Asn Ile Ser Gln Pro Glu 
            260                 265                 270         


Thr Thr Lys Glu Gly Leu Arg Ala Ile Ser Asp Val Ser Asp Leu Glu 
        275                 280                 285             


Glu Thr Thr Thr Leu Ala Ser Phe Ile Ser Glu Val Val Ser Ser Ala 
    290                 295                 300                 


Pro Tyr Trp Gly Trp Ala Ile Ile Lys Ser Tyr Asp Leu Asp Pro Gly 
305                 310                 315                 320 


Ala Gly Ser Leu Glu Ile 
                325     


<210> 26
<211> 1722
<212> DNA
<213> Homo sapiens

<400> 26
aggcagaaca ggatcaggaa gcgatcaaac ctaccaaggc agtctcactt ctcaatgact       60

ggactgtgtg ggtactctgc tccagacatg cgtggcctca gactcatcat gataccagtt      120

gagctgctac tttgctacct cctgctgcac cctgtggatg ccacttcata tggaaagcag      180

acaaatgtct tgatgcactt tcccttgtcc ttggaatccc agacaccctc ctcagacccc      240

ttgtcctgcc aatttctgca cccaaagtca ctgcctggtt tcagccacat ggcccctcta      300

cccaagttct tggtaagcct ggctctaagg aatgccctgg aggaagctgg ttgtcaggct      360

gatgtttggg ctctacagct acagctctac cgccagggtg gtgtgaatgc tacacaggtc      420

ctcatccagc atcttcgagg gctccagaaa ggcagaagca cagagaggaa cgtgtcagtg      480

gaagccctgg cctctgctct gcagctgtta gccagggagc agcaaagcac aggaagggtc      540

gggcgctccc tcccgacaga ggactgtgag aatgagaagg agcaagctgt gcacaatgta      600

gtccagctgc tgccaggagt gggaaccttc tacaacctgg gcacagcttt gtattatgct      660

actcaaaact gcctgggcaa ggccagggaa cgaggccgag atggggccat agatctggga      720

tatgaccttc tgatgaccat ggctgggatg tcaggggggc ctatgggtct agcgatcagt      780

gctgcactta aacctgcatt aaggtctggg gttcagcagt tgatccagta ttaccaagat      840

cagaaagacg caaacatctc tcagccggag accaccaagg agggtttgag ggccatctca      900

gatgtgagtg acttggaaga aacaactact ctggcttctt tcatatcaga agtagtaagt      960

tcagctccct actgggggtg ggccataatc aagagctatg acttagatcc tggggctggg     1020

agtcttgaga tataaaagaa tgtggtaacc acagaattaa taactgtact accctgacaa     1080

gctatataca tgtcttcaaa attttaatct gatttatcca ggaggaaggc tgtacagtaa     1140

aacgtaagaa cgtaaatgtt tgggtgttga agtcacaggg tttggtttcg aatctaggct     1200

ccacttgtta gagcctcggt gatcactgaa tagtaacttc tttcttgaac taagatcagt     1260

tttgaagttt ctaaaggaga tagaatgatt ttaacctcaa tgagttgccc tgtaaattta     1320

aaatgataca atgaatctaa aatgcttatc acagtacttt caataaatag ctattagcca     1380

ggtgcggtgg ctcacgcctg taatcccagc actgtgagag gctgaggcgg gatgatcacc     1440

tgaggtcagg agttcaagat cagcctgggc aacatggcga aaccccgtct ctacaataaa     1500

tacaaaaaat tatcctggcg gagttatgca cgcttgtagt cccaactacc tgggaggctg     1560

aggcgggaga atcacctgag cctgggaggt cgaggctgca gcgagccgag atcgcgccgc     1620

tgcattccag cctgggtgac agagcgagac catgtctcaa aaaaaataaa aataaaaaaa     1680

aattgttttc acaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa                        1722


<210> 27
<211> 3653
<212> DNA
<213> Homo sapiens

<400> 27
gcgccagcgc cggcgggacc cgagctgcta atgaggcagc catgactggc cacttcatgt       60

gctcctggag aagggcttgc accagccgtt ttcaggaaag tcaagcagct gttgactcct      120

gagtctgggt gaatttgtgt gaagagcata aggcgctgtt tcttaaccaa aacgcttcct      180

cttgcagtgc agatgggatg tgcttctcca caggaggccc cacggcttcc ccacccctca      240

gaggagcgcc gtgcgtgcgt ctgtgtggag gattggcagc tcctgcagtc ggcccttggt      300

cctatttggc gacgcctctg ccttcccctt aattatacag tcatgagccg ccctggaatc      360

acggcagctc cggatggatc ctggatgcca gaatgcagcc tcagcacggg gctgcaggat      420

aggagtgagc gaggggctgc agagccggcg gccgcggtgg gcaccatgga gggggctgcc      480

ctgggcagca cgggcatgag tctcaaggcc caggtttgag taacaggtgt tgagagctta      540

cttacttttc ctgagacaca gtttcctcat ctcgagagca cggaaaatca ttctaacttc      600

agaggattgt tgtgaaagtt aaatgagatt aaagaggtaa agcccatgac gtgcttagct      660

cgtgcttggc tcttggtcaa tgccagttag cgctgcattt tctcccctct ccctccctcc      720

ttctctcttt cttttcttct attctccatt cctgttttct cccccacccc actccccaaa      780

gctctgcgtt gagaaccaga tgctgtctgg tgggttaggg ccagaggagg aaaagctgcc      840

tgccgtgggc tgcacccata ccctcttcat tccaatgaca tgaggggagg ggaaaggaca      900

gaggtagact gtcctcccct acctcctcct aatacaaatg gaattcctgg aactggaaaa      960

caaagaatac ccccataaaa ataagacagt acttctggtg cggtgtaata aaggggaaag     1020

taaccctcaa tgtcaggaaa ctccgcacct cccagctcat atttgtgtgg aggaaaagtt     1080

aaatattaat ttggactcaa ctgaatgtgg acacaaacaa tggtcaccaa gtcccggaac     1140

aggttgtgtg agcctcttca ggggttcatc cagcgctgtt ttggagaaat ctctatttca     1200

atttattcct atacgttagt tactgaaaaa caacagacaa tcgcaaaagc aagttgcccg     1260

ttttgtgttc cttgagccca atcatgaagt gccgtcgtga ctgggcctca tgacaaacaa     1320

cttgtaataa gtaacaacag agctcaggtc ccagaccgca ctgaagctct gtgagacctc     1380

tcctcatctg tgcatgaacg agtgtctgac tctggagccc agcctgctgc ttcccagtct     1440

ggtggtgaat cctccgtagt ctgatggagg tttgctcttg ttgcccaggc tggagtgcaa     1500

tggcacaatc tcggctcact gcagcccctg cctcccaggc tcaagcaatt cttatgcctc     1560

agcctcctga gtagatggaa ctacagggca tggactggaa ctcccaatac ccctgacatg     1620

ggctgagtca acgtggtcat gaacatgtga caggaggcag cagaagttgc agaaaagagt     1680

gaggcacgtt tgaaaaaggc tgaaaaatgt ttctgtccag gcaagggtgt gtgctgaatg     1740

actcaaggat tttttggaga gaattggagt gtctcaccag aggagaccac gtctgaaggg     1800

ctttgcatcc ctccttggac atgtctaata cctagcactc agaaagcatc cagtaaatat     1860

tcgtggaaag aaaggagtgg agaaggggag aaaggggaaa gggagtaggc gagagagaag     1920

aaagactctg cttcttgccc agggcctggc atggggcgga ggcaaagcag tggggtcctc     1980

agctatgtcc cactgtgagt gcacagcgag tcctgacctt cagagggtgc agcccgaggg     2040

gccctggcct gtctgaaggg tgcgccagcc gagtggcctg ctctgaccac caggctcacc     2100

catgactacc tgggtggcta cagccagttc ctgacaatga gtacagcact cagttatcgg     2160

ggcccttcca cccacacgct gtccacttcc tggggtactg ctgtgggcat gcgagtgctt     2220

gctccccggg gcactgctgt gggcatgcga gtgcttgctc cccggggcac tgctgtgggc     2280

atgtgagtgc ttgctcccca gctccactag tgacactggt ggccccttgc tggggccttc     2340

cccgcctgct ccgctccatt accgctgccg ggctcctcac gtctctcctt gctgcttcct     2400

gcactggggt gaggagagtg gggctggtcc ccttgagacc ggagaagctc caggctttta     2460

aggaaaactg ccagggacga agagaagata tcacttcccc acgtggttgg cttccagatt     2520

cagaaggaat gtctgtcctt gtggattccg taccagatga ccccagatgc tgcctcagta     2580

ctaggtccct gtggctctgg agcctttgct gggtctgggc agtgtctctt cctctccagt     2640

tcatccttgg gtctcttcac ccttgccagg ggcaggcttc ctggtgagag gtcgacctcc     2700

tgcatgaagg ctctcaagag gccagttcaa agccaagctc cgggtctgtg cctgtggggc     2760

tgctcctcga tcaggagatg gtcactcccc tcctggtctg tatctgtggg attctcctcc     2820

atcaggagat ggtctctccc ctcctggtct atacccgtgg gattctcctc catcaggaga     2880

tggtcactcc ccatcctggt ctatacccgt gggattctcc tccattagat ggtcactccc     2940

ctcctggtct attcccgtgg ggctgctcct ccatcaggag gtggtcactc cccctcctgg     3000

tctatacccg tggggctgct cctccatcag gagatagtca ctccccctcc tggtctatac     3060

ccgtgggatt ctcctccatc tggagatggt cactcccctc ctggtctata cccatgggat     3120

tctcctccat ctggagatgg tcactcccct cctggtctat acccatggga ttctcctcca     3180

tctggagata gtcactcccc tcctggtcta tacccgtggg gttctcctca atcaggaggt     3240

ggtcactccc ctcctggtct atacccgtgg gattctcctc catcaggaga tggtcactct     3300

ccctcctggt ctatacccgt ggggctgctc ctccatcagg agatggtcac tcccctcctg     3360

gtctatacct gtgggattct cctccctcag aagatggtca ctccccctcc tggtctatac     3420

ccatgggatt ctcctccctc agaagatggt cactccccct cctggtctat acccgtgggg     3480

ctgctcctcc atcaggagat ggtcactctc cctctcggtt gctcagtcca aaaacaacct     3540

ctctggaaaa ctgcgtggaa ttttttttta aagaattgaa actagaacta gcatttgatc     3600

cagccatctg cctactggga atacacccaa agaaaaataa atcattatat cag            3653


<210> 28
<211> 1214
<212> PRT
<213> Homo sapiens

<400> 28
Met Val Val Pro Glu Lys Glu Gln Ser Trp Ile Pro Lys Ile Phe Lys 
1               5                   10                  15      


Lys Lys Thr Cys Thr Thr Phe Ile Val Asp Ser Thr Asp Pro Gly Gly 
            20                  25                  30          


Thr Leu Cys Gln Cys Gly Arg Pro Arg Thr Ala His Pro Ala Val Ala 
        35                  40                  45              


Met Glu Asp Ala Phe Gly Ala Ala Val Val Thr Val Trp Asp Ser Asp 
    50                  55                  60                  


Ala His Thr Thr Glu Lys Pro Thr Asp Ala Tyr Gly Glu Leu Asp Phe 
65                  70                  75                  80  


Thr Gly Ala Gly Arg Lys His Ser Asn Phe Leu Arg Leu Ser Asp Arg 
                85                  90                  95      


Thr Asp Pro Ala Ala Val Tyr Ser Leu Val Thr Arg Thr Trp Gly Phe 
            100                 105                 110         


Arg Ala Pro Asn Leu Val Val Ser Val Leu Gly Gly Ser Gly Gly Pro 
        115                 120                 125             


Val Leu Gln Thr Trp Leu Gln Asp Leu Leu Arg Arg Gly Leu Val Arg 
    130                 135                 140                 


Ala Ala Gln Ser Thr Gly Ala Trp Ile Val Thr Gly Gly Leu His Thr 
145                 150                 155                 160 


Gly Ile Gly Arg His Val Gly Val Ala Val Arg Asp His Gln Met Ala 
                165                 170                 175     


Ser Thr Gly Gly Thr Lys Val Val Ala Met Gly Val Ala Pro Trp Gly 
            180                 185                 190         


Val Val Arg Asn Arg Asp Thr Leu Ile Asn Pro Lys Gly Ser Phe Pro 
        195                 200                 205             


Ala Arg Tyr Arg Trp Arg Gly Asp Pro Glu Asp Gly Val Gln Phe Pro 
    210                 215                 220                 


Leu Asp Tyr Asn Tyr Ser Ala Phe Phe Leu Val Asp Asp Gly Thr His 
225                 230                 235                 240 


Gly Cys Leu Gly Gly Glu Asn Arg Phe Arg Leu Arg Leu Glu Ser Tyr 
                245                 250                 255     


Ile Ser Gln Gln Lys Thr Gly Val Gly Gly Thr Gly Ile Asp Ile Pro 
            260                 265                 270         


Val Leu Leu Leu Leu Ile Asp Gly Asp Glu Lys Met Leu Thr Arg Ile 
        275                 280                 285             


Glu Asn Ala Thr Gln Ala Gln Leu Pro Cys Leu Leu Val Ala Gly Ser 
    290                 295                 300                 


Gly Gly Ala Ala Asp Cys Leu Ala Glu Thr Leu Glu Asp Thr Leu Ala 
305                 310                 315                 320 


Pro Gly Ser Gly Gly Ala Arg Gln Gly Glu Ala Arg Asp Arg Ile Arg 
                325                 330                 335     


Arg Phe Phe Pro Lys Gly Asp Leu Glu Val Leu Gln Ala Gln Val Glu 
            340                 345                 350         


Arg Ile Met Thr Arg Lys Glu Leu Leu Thr Val Tyr Ser Ser Glu Asp 
        355                 360                 365             


Gly Ser Glu Glu Phe Glu Thr Ile Val Leu Lys Ala Leu Val Lys Ala 
    370                 375                 380                 


Cys Gly Ser Ser Glu Ala Ser Ala Tyr Leu Asp Glu Leu Arg Leu Ala 
385                 390                 395                 400 


Val Ala Trp Asn Arg Val Asp Ile Ala Gln Ser Glu Leu Phe Arg Gly 
                405                 410                 415     


Asp Ile Gln Trp Arg Ser Phe His Leu Glu Ala Ser Leu Met Asp Ala 
            420                 425                 430         


Leu Leu Asn Asp Arg Pro Glu Phe Val Arg Leu Leu Ile Ser His Gly 
        435                 440                 445             


Leu Ser Leu Gly His Phe Leu Thr Pro Met Arg Leu Ala Gln Leu Tyr 
    450                 455                 460                 


Ser Ala Ala Pro Ser Asn Ser Leu Ile Arg Asn Leu Leu Asp Gln Ala 
465                 470                 475                 480 


Ser His Ser Ala Gly Thr Lys Ala Pro Ala Leu Lys Gly Gly Ala Ala 
                485                 490                 495     


Glu Leu Arg Pro Pro Asp Val Gly His Val Leu Arg Met Leu Leu Gly 
            500                 505                 510         


Lys Met Cys Ala Pro Arg Tyr Pro Ser Gly Gly Ala Trp Asp Pro His 
        515                 520                 525             


Pro Gly Gln Gly Phe Gly Glu Ser Met Tyr Leu Leu Ser Asp Lys Ala 
    530                 535                 540                 


Thr Ser Pro Leu Ser Leu Asp Ala Gly Leu Gly Gln Ala Pro Trp Ser 
545                 550                 555                 560 


Asp Leu Leu Leu Trp Ala Leu Leu Leu Asn Arg Ala Gln Met Ala Met 
                565                 570                 575     


Tyr Phe Trp Glu Met Gly Ser Asn Ala Val Ser Ser Ala Leu Gly Ala 
            580                 585                 590         


Cys Leu Leu Leu Arg Val Met Ala Arg Leu Glu Pro Asp Ala Glu Glu 
        595                 600                 605             


Ala Ala Arg Arg Lys Asp Leu Ala Phe Lys Phe Glu Gly Met Gly Val 
    610                 615                 620                 


Asp Leu Phe Gly Glu Cys Tyr Arg Ser Ser Glu Val Arg Ala Ala Arg 
625                 630                 635                 640 


Leu Leu Leu Arg Arg Cys Pro Leu Trp Gly Asp Ala Thr Cys Leu Gln 
                645                 650                 655     


Leu Ala Met Gln Ala Asp Ala Arg Ala Phe Phe Ala Gln Asp Gly Val 
            660                 665                 670         


Gln Ser Leu Leu Thr Gln Lys Trp Trp Gly Asp Met Ala Ser Thr Thr 
        675                 680                 685             


Pro Ile Trp Ala Leu Val Leu Ala Phe Phe Cys Pro Pro Leu Ile Tyr 
    690                 695                 700                 


Thr Arg Leu Ile Thr Phe Arg Lys Ser Glu Glu Glu Pro Thr Arg Glu 
705                 710                 715                 720 


Glu Leu Glu Phe Asp Met Asp Ser Val Ile Asn Gly Glu Gly Pro Val 
                725                 730                 735     


Gly Thr Ala Asp Pro Ala Glu Lys Thr Pro Leu Gly Val Pro Arg Gln 
            740                 745                 750         


Ser Gly Arg Pro Gly Cys Cys Gly Gly Arg Cys Gly Gly Arg Arg Cys 
        755                 760                 765             


Leu Arg Arg Trp Phe His Phe Trp Gly Ala Pro Val Thr Ile Phe Met 
    770                 775                 780                 


Gly Asn Val Val Ser Tyr Leu Leu Phe Leu Leu Leu Phe Ser Arg Val 
785                 790                 795                 800 


Leu Leu Val Asp Phe Gln Pro Ala Pro Pro Gly Ser Leu Glu Leu Leu 
                805                 810                 815     


Leu Tyr Phe Trp Ala Phe Thr Leu Leu Cys Glu Glu Leu Arg Gln Gly 
            820                 825                 830         


Leu Ser Gly Gly Gly Gly Ser Leu Ala Ser Gly Gly Pro Gly Pro Gly 
        835                 840                 845             


His Ala Ser Leu Ser Gln Arg Leu Arg Leu Tyr Leu Ala Asp Ser Trp 
    850                 855                 860                 


Asn Gln Cys Asp Leu Val Ala Leu Thr Cys Phe Leu Leu Gly Val Gly 
865                 870                 875                 880 


Cys Arg Leu Thr Pro Gly Leu Tyr His Leu Gly Arg Thr Val Leu Cys 
                885                 890                 895     


Ile Asp Phe Met Val Phe Thr Val Arg Leu Leu His Ile Phe Thr Val 
            900                 905                 910         


Asn Lys Gln Leu Gly Pro Lys Ile Val Ile Val Ser Lys Met Met Lys 
        915                 920                 925             


Asp Val Phe Phe Phe Leu Phe Phe Leu Gly Val Trp Leu Val Ala Tyr 
    930                 935                 940                 


Gly Val Ala Thr Glu Gly Leu Leu Arg Pro Arg Asp Ser Asp Phe Pro 
945                 950                 955                 960 


Ser Ile Leu Arg Arg Val Phe Tyr Arg Pro Tyr Leu Gln Ile Phe Gly 
                965                 970                 975     


Gln Ile Pro Gln Glu Asp Met Asp Val Ala Leu Met Glu His Ser Asn 
            980                 985                 990         


Cys Ser Ser Glu Pro Gly Phe Trp  Ala His Pro Pro Gly  Ala Gln Ala 
        995                 1000                 1005             


Gly Thr  Cys Val Ser Gln Tyr  Ala Asn Trp Leu Val  Val Leu Leu 
    1010                 1015                 1020             


Leu Val  Ile Phe Leu Leu Val  Ala Asn Ile Leu Leu  Val Asn Leu 
    1025                 1030                 1035             


Leu Ile  Ala Met Phe Ser Tyr  Thr Phe Gly Lys Val  Gln Gly Asn 
    1040                 1045                 1050             


Ser Asp  Leu Tyr Trp Lys Ala  Gln Arg Tyr Arg Leu  Ile Arg Glu 
    1055                 1060                 1065             


Phe His  Ser Arg Pro Ala Leu  Ala Pro Pro Phe Ile  Val Ile Ser 
    1070                 1075                 1080             


His Leu  Arg Leu Leu Leu Arg  Gln Leu Cys Arg Arg  Pro Arg Ser 
    1085                 1090                 1095             


Pro Gln  Pro Ser Ser Pro Ala  Leu Glu His Phe Arg  Val Tyr Leu 
    1100                 1105                 1110             


Ser Lys  Glu Ala Glu Arg Lys  Leu Leu Thr Trp Glu  Ser Val His 
    1115                 1120                 1125             


Lys Glu  Asn Phe Leu Leu Ala  Arg Ala Arg Asp Lys  Arg Glu Ser 
    1130                 1135                 1140             


Asp Ser  Glu Arg Leu Lys Arg  Thr Ser Gln Lys Val  Asp Leu Ala 
    1145                 1150                 1155             


Leu Lys  Gln Leu Gly His Ile  Arg Glu Tyr Glu Gln  Arg Leu Lys 
    1160                 1165                 1170             


Val Leu  Glu Arg Glu Val Gln  Gln Cys Ser Arg Val  Leu Gly Trp 
    1175                 1180                 1185             


Val Ala  Glu Ala Leu Ser Arg  Ser Ala Leu Leu Pro  Pro Gly Gly 
    1190                 1195                 1200             


Pro Pro  Pro Pro Asp Leu Pro  Gly Ser Lys Asp 
    1205                 1210                 


<210> 29
<211> 4103
<212> DNA
<213> Homo sapiens

<400> 29
aggctggaaa gtggaggatc cggtttgctc tgggcgggtc tggaagcaga gccggcggag       60

ggagcgccgg ggccctgggc tgcaggaggt tgcggcggcc gcggcagcat ggtggtgccg      120

gagaaggagc agagctggat ccccaagatc ttcaagaaga agacctgcac gacgttcata      180

gttgactcca cagatccggg agggaccttg tgccagtgtg ggcgcccccg gaccgcccac      240

cccgcagtgg ccatggagga tgccttcggg gcagccgtgg tgaccgtgtg ggacagcgat      300

gcacacacca cggagaagcc caccgatgcc tacggagagc tggacttcac gggggccggc      360

cgcaagcaca gcaatttcct ccggctctct gaccgaacgg atccagctgc agtttatagt      420

ctggtcacac gcacatgggg cttccgtgcc ccgaacctgg tggtgtcagt gctgggggga      480

tcggggggcc ccgtcctcca gacctggctg caggacctgc tgcgtcgtgg gctggtgcgg      540

gctgcccaga gcacaggagc ctggattgtc actgggggtc tgcacacggg catcggccgg      600

catgttggtg tggctgtacg ggaccatcag atggccagca ctgggggcac caaggtggtg      660

gccatgggtg tggccccctg gggtgtggtc cggaatagag acaccctcat caaccccaag      720

ggctcgttcc ctgcgaggta ccggtggcgc ggtgacccgg aggacggggt ccagtttccc      780

ctggactaca actactcggc cttcttcctg gtggacgacg gcacacacgg ctgcctgggg      840

ggcgagaacc gcttccgctt gcgcctggag tcctacatct cacagcagaa gacgggcgtg      900

ggagggactg gaattgacat ccctgtcctg ctcctcctga ttgatggtga tgagaagatg      960

ttgacgcgaa tagagaacgc cacccaggct cagctcccat gtctcctcgt ggctggctca     1020

gggggagctg cggactgcct ggcggagacc ctggaagaca ctctggcccc agggagtggg     1080

ggagccaggc aaggcgaagc ccgagatcga atcaggcgtt tctttcccaa aggggacctt     1140

gaggtcctgc aggcccaggt ggagaggatt atgacccgga aggagctcct gacagtctat     1200

tcttctgagg atgggtctga ggaattcgag accatagttt tgaaggccct tgtgaaggcc     1260

tgtgggagct cggaggcctc agcctacctg gatgagctgc gtttggctgt ggcttggaac     1320

cgcgtggaca ttgcccagag tgaactcttt cggggggaca tccaatggcg gtccttccat     1380

ctcgaagctt ccctcatgga cgccctgctg aatgaccggc ctgagttcgt gcgcttgctc     1440

atttcccacg gcctcagcct gggccacttc ctgaccccga tgcgcctggc ccaactctac     1500

agcgcggcgc cctccaactc gctcatccgc aaccttttgg accaggcgtc ccacagcgca     1560

ggcaccaaag ccccagccct aaaaggggga gctgcggagc tccggccccc tgacgtgggg     1620

catgtgctga ggatgctgct ggggaagatg tgcgcgccga ggtacccctc cgggggcgcc     1680

tgggaccctc acccaggcca gggcttcggg gagagcatgt atctgctctc ggacaaggcc     1740

acctcgccgc tctcgctgga tgctggcctc gggcaggccc cctggagcga cctgcttctt     1800

tgggcactgt tgctgaacag ggcacagatg gccatgtact tctgggagat gggttccaat     1860

gcagtttcct cagctcttgg ggcctgtttg ctgctccggg tgatggcacg cctggagcct     1920

gacgctgagg aggcagcacg gaggaaagac ctggcgttca agtttgaggg gatgggcgtt     1980

gacctctttg gcgagtgcta tcgcagcagt gaggtgaggg ctgcccgcct cctcctccgt     2040

cgctgcccgc tctgggggga tgccacttgc ctccagctgg ccatgcaagc tgacgcccgt     2100

gccttctttg cccaggatgg ggtacagtct ctgctgacac agaagtggtg gggagatatg     2160

gccagcacta cacccatctg ggccctggtt ctcgccttct tttgccctcc actcatctac     2220

acccgcctca tcaccttcag gaaatcagaa gaggagccca cacgggagga gctagagttt     2280

gacatggata gtgtcattaa tggggaaggg cctgtcggga cggcggaccc agccgagaag     2340

acgccgctgg gggtcccgcg ccagtcgggc cgtccgggtt gctgcggggg ccgctgcggg     2400

gggcgccggt gcctacgccg ctggttccac ttctggggcg cgccggtgac catcttcatg     2460

ggcaacgtgg tcagctacct gctgttcctg ctgcttttct cgcgggtgct gctcgtggat     2520

ttccagccgg cgccgcccgg ctccctggag ctgctgctct atttctgggc tttcacgctg     2580

ctgtgcgagg aactgcgcca gggcctgagc ggaggcgggg gcagcctcgc cagcgggggc     2640

cccgggcctg gccatgcctc actgagccag cgcctgcgcc tctacctcgc cgacagctgg     2700

aaccagtgcg acctagtggc tctcacctgc ttcctcctgg gcgtgggctg ccggctgacc     2760

ccgggtttgt accacctggg ccgcactgtc ctctgcatcg acttcatggt tttcacggtg     2820

cggctgcttc acatcttcac ggtcaacaaa cagctggggc ccaagatcgt catcgtgagc     2880

aagatgatga aggacgtgtt cttcttcctc ttcttcctcg gcgtgtggct ggtagcctat     2940

ggcgtggcca cggaggggct cctgaggcca cgggacagtg acttcccaag tatcctgcgc     3000

cgcgtcttct accgtcccta cctgcagatc ttcgggcaga ttccccagga ggacatggac     3060

gtggccctca tggagcacag caactgctcg tcggagcccg gcttctgggc acaccctcct     3120

ggggcccagg cgggcacctg cgtctcccag tatgccaact ggctggtggt gctgctcctc     3180

gtcatcttcc tgctcgtggc caacatcctg ctggtcaact tgctcattgc catgttcagt     3240

tacacattcg gcaaagtaca gggcaacagc gatctctact ggaaggcgca gcgttaccgc     3300

ctcatccggg aattccactc tcggcccgcg ctggccccgc cctttatcgt catctcccac     3360

ttgcgcctcc tgctcaggca attgtgcagg cgaccccgga gcccccagcc gtcctccccg     3420

gccctcgagc atttccgggt ttacctttct aaggaagccg agcggaagct gctaacgtgg     3480

gaatcggtgc ataaggagaa ctttctgctg gcacgcgcta gggacaagcg ggagagcgac     3540

tccgagcgtc tgaagcgcac gtcccagaag gtggacttgg cactgaaaca gctgggacac     3600

atccgcgagt acgaacagcg cctgaaagtg ctggagcggg aggtccagca gtgtagccgc     3660

gtcctggggt gggtggccga ggccctgagc cgctctgcct tgctgccccc aggtgggccg     3720

ccaccccctg acctgcctgg gtccaaagac tgagccctgc tggcggactt caaggagaag     3780

cccccacagg ggattttgct cctagagtaa ggctcatctg ggcctcggcc cccgcacctg     3840

gtggccttgt ccttgaggtg agccccatgt ccatctgggc cactgtcagg accacctttg     3900

ggagtgtcat ccttacaaac cacagcatgc ccggctcctc ccagaaccag tcccagcctg     3960

ggaggatcaa ggcctggatc ccgggccgtt atccatctgg aggctgcagg gtccttgggg     4020

taacagggac cacagacccc tcaccactca cagattcctc acactgggga aataaagcca     4080

tttcagagga atcgtgaaaa aaa                                             4103


<210> 30
<211> 3923
<212> DNA
<213> Homo sapiens

<400> 30
acagaagaaa tagcaagtgc cgagaagctg gcatcagaaa aacagagggg agatttgtgt       60

ggctgcagcc gagggagacc aggaagatct gcatggtggg aaggacctga tgatacagag      120

gaattacaac acatatactt agtgtttcaa tgaacaccaa gataaataag tgaagagcta      180

gtccgctgtg agtctcctca gtgacacagg gctggatcac catcgacggc actttctgag      240

tactcagtgc agcaaagaaa gactacagac atctcaatgg caggggtgag aaataagaaa      300

ggctgctgac tttaccatct gaggccacac atctgctgaa atggagataa ttaacatcac      360

tagaaacagc aagatgacaa tataatgtct aagtagtgac atgtttttgc acatttccag      420

cccctttaaa tatccacaca cacaggaagc acaaaaggaa gcacagagat ccctgggaga      480

aatgcccggc cgccatcttg ggtcatcgat gagcctcgcc ctgtgcctgg tcccgcttgt      540

gagggaagga cattagaaaa tgaattgatg tgttccttaa aggatgggca ggaaaacaga      600

tcctgttgtg gatatttatt tgaacgggat tacagatttg aaatgaagtc acaaagtgag      660

cattaccaat gagaggaaaa cagacgagaa aatcttgatg gcttcacaag acatgcaaca      720

aacaaaatgg aatactgtga tgacatgagg cagccaagct ggggaggaga taaccacggg      780

gcagagggtc aggattctgg ccctgctgcc taaactgtgc gttcataacc aaatcatttc      840

atatttctaa ccctcaaaac aaagctgttg taatatctga tctctacggt tccttctggg      900

cccaacattc tccatatatc cagccacact catttttaat atttagttcc cagatctgta      960

ctgtgacctt tctacactgt agaataacat tactcatttt gttcaaagac ccttcgtgtt     1020

gctgcctaat atgtagctga ctgtttttcc taaggagtgt tctggcccag gggatctgtg     1080

aacaggctgg gaagcatctc aagatctttc cagggttata cttactagca cacagcatga     1140

tcattacgga gtgaattatc taatcaacat catcctcagt gtctttgccc atactgaaat     1200

tcatttccca cttttgtgcc cattctcaag acctcaaaat gtcattccat taatatcaca     1260

ggattaactt ttttttttaa cctggaagaa ttcaatgtta catgcagcta tgggaattta     1320

attacatatt ttgttttcca gtgcaaagat gactaagtcc tttatccctc ccctttgttt     1380

gatttttttt ccagtataaa gttaaaatgc ttagccttgt actgaggctg tatacagcac     1440

agcctctccc catccctcca gccttatctg tcatcaccat caacccctcc cataccacct     1500

aaacaaaatc taacttgtaa ttccttgaac atgtcaggac atacattatt ccttctgcct     1560

gagaagctct tccttgtctc ttaaatctag aatgatgtaa agttttgaat aagttgacta     1620

tcttacttca tgcaaagaag ggacacatat gagattcatc atcacatgag acagcaaata     1680

ctaaaagtgt aatttgatta taagagttta gataaatata tgaaatgcaa gagccacaga     1740

gggaatgttt atggggcacg tttgtaagcc tgggatgtga agcaaaggca gggaacctca     1800

tagtatctta tataatatac ttcatttctc tatctctatc acaatatcca acaagctttt     1860

cacagaattc atgcagtgca aatccccaaa ggtaaccttt atccatttca tggtgagtgc     1920

gctttagaat tttggcaaat catactggtc acttatctca actttgagat gtgtttgtcc     1980

ttgtagttaa ttgaaagaaa tagggcactc ttgtgagcca ctttagggtt cactcctggc     2040

aataaagaat ttacaaagag ctactcagga ccagttgtta agagctctgt gtgtgtgtgt     2100

gtgtgtgtgt gagtgtacat gccaaagtgt gcctctctct cttgacccat tatttcagac     2160

ttaaaacaag catgttttca aatggcacta tgagctgcca atgatgtatc accaccatat     2220

ctcattattc tccagtaaat gtgataataa tgtcatctgt taacataaaa aaagtttgac     2280

ttcacaaaag cagctggaaa tggacaacca caatatgcat aaatctaact cctaccatca     2340

gctacacact gcttgacata tattgttaga agcacctcgc atttgtgggt tctcttaagc     2400

aaaatacttg cattaggtct cagctggggc tgtgcatcag gcggtttgag aaatattcaa     2460

ttctcagcag aagccagaat ttgaattccc tcatctttta ggaatcattt accaggtttg     2520

gagaggattc agacagctca ggtgctttca ctaatgtctc tgaacttctg tccctctttg     2580

tgttcatgga tagtccaata aataatgtta tctttgaact gatgctcata ggagagaata     2640

taagaactct gagtgatatc aacattaggg attcaaagaa atattagatt taagctcaca     2700

ctggtcaaaa ggaaccaaga tacaaagaac tctgagctgt catcgtcccc atctctgtga     2760

gccacaacca acagcaggac ccaacgcatg tctgagatcc ttaaatcaag gaaaccagtg     2820

tcatgagttg aattctccta ttatggatgc tagcttctgg ccatctctgg ctctcctctt     2880

gacacatatt agcttctagc ctttgcttcc acgactttta tcttttctcc aacacatcgc     2940

ttaccaatcc tctctctgct ctgttgcttt ggacttcccc acaagaattt caacgactct     3000

caagtctttt cttccatccc caccactaac ctgaatgcct agacccttat ttttattaat     3060

ttccaataga tgctgcctat gggctatatt gctttagatg aacattagat atttaaagct     3120

caagaggttc aaaatccaac tcattatctt ctctttcttt cacctccctg ctcctctccc     3180

tatattactg attgcactga acagcatggt ccccaatgta gccatgcaaa tgagaaaccc     3240

agtggctcct tgtggtacat gcatgcaaga ctgctgaagc cagaaggatg actgattacg     3300

cctcatgggt ggaggggacc actcctgggc cttcgtgatt gtcaggagca agacctgaga     3360

tgctccctgc cttcagtgtc ctctgcatct cccctttcta atgaagatcc atagaatttg     3420

ctacatttga gaattccaat taggaactca catgttttat ctgccctatc aattttttaa     3480

acttgctgaa aattaagttt tttcaaaatc tgtccttgta aattactttt tcttacagtg     3540

tcttggcata ctatatcaac tttgattctt tgttacaact tttcttactc ttttatcacc     3600

aaagtggctt ttattctctt tattattatt attttctttt actactatat tacgttgtta     3660

ttattttgtt ctctatagta tcaatttatt tgatttagtt tcaatttatt tttattgctg     3720

acttttaaaa taagtgattc ggggggtggg agaacagggg agggagagca ttaggacaaa     3780

tacctaatgc atgtgggact taaaacctag atgatgggtt gataggtgca gcaaaccact     3840

atggcacacg tatacctgtg taacaaacct acacattctg cacatgtatc ccagaacgta     3900

aagtaaaatt taaaaaaaag tga                                             3923


<210> 31
<211> 662
<212> PRT
<213> Homo sapiens

<400> 31
Met Gly Leu Tyr Arg Ile Arg Val Ser Thr Gly Ala Ser Leu Tyr Ala 
1               5                   10                  15      


Gly Ser Asn Asn Gln Val Gln Leu Trp Leu Val Gly Gln His Gly Glu 
            20                  25                  30          


Ala Ala Leu Gly Lys Arg Leu Trp Pro Ala Arg Gly Lys Glu Thr Glu 
        35                  40                  45              


Leu Lys Val Glu Val Pro Glu Tyr Leu Gly Pro Leu Leu Phe Val Lys 
    50                  55                  60                  


Leu Arg Lys Arg His Leu Leu Lys Asp Asp Ala Trp Phe Cys Asn Trp 
65                  70                  75                  80  


Ile Ser Val Gln Gly Pro Gly Ala Gly Asp Glu Val Arg Phe Pro Cys 
                85                  90                  95      


Tyr Arg Trp Val Glu Gly Asn Gly Val Leu Ser Leu Pro Glu Gly Thr 
            100                 105                 110         


Gly Arg Thr Val Gly Glu Asp Pro Gln Gly Leu Phe Gln Lys His Arg 
        115                 120                 125             


Glu Glu Glu Leu Glu Glu Arg Arg Lys Leu Tyr Arg Trp Gly Asn Trp 
    130                 135                 140                 


Lys Asp Gly Leu Ile Leu Asn Met Ala Gly Ala Lys Leu Tyr Asp Leu 
145                 150                 155                 160 


Pro Val Asp Glu Arg Phe Leu Glu Asp Lys Arg Val Asp Phe Glu Val 
                165                 170                 175     


Ser Leu Ala Lys Gly Leu Ala Asp Leu Ala Ile Lys Asp Ser Leu Asn 
            180                 185                 190         


Val Leu Thr Cys Trp Lys Asp Leu Asp Asp Phe Asn Arg Ile Phe Trp 
        195                 200                 205             


Cys Gly Gln Ser Lys Leu Ala Glu Arg Val Arg Asp Ser Trp Lys Glu 
    210                 215                 220                 


Asp Ala Leu Phe Gly Tyr Gln Phe Leu Asn Gly Ala Asn Pro Val Val 
225                 230                 235                 240 


Leu Arg Arg Ser Ala His Leu Pro Ala Arg Leu Val Phe Pro Pro Gly 
                245                 250                 255     


Met Glu Glu Leu Gln Ala Gln Leu Glu Lys Glu Leu Glu Gly Gly Thr 
            260                 265                 270         


Leu Phe Glu Ala Asp Phe Ser Leu Leu Asp Gly Ile Lys Ala Asn Val 
        275                 280                 285             


Ile Leu Cys Ser Gln Gln His Leu Ala Ala Pro Leu Val Met Leu Lys 
    290                 295                 300                 


Leu Gln Pro Asp Gly Lys Leu Leu Pro Met Val Ile Gln Leu Gln Leu 
305                 310                 315                 320 


Pro Arg Thr Gly Ser Pro Pro Pro Pro Leu Phe Leu Pro Thr Asp Pro 
                325                 330                 335     


Pro Met Ala Trp Leu Leu Ala Lys Cys Trp Val Arg Ser Ser Asp Phe 
            340                 345                 350         


Gln Leu His Glu Leu Gln Ser His Leu Leu Arg Gly His Leu Met Ala 
        355                 360                 365             


Glu Val Ile Val Val Ala Thr Met Arg Cys Leu Pro Ser Ile His Pro 
    370                 375                 380                 


Ile Phe Lys Leu Ile Ile Pro His Leu Arg Tyr Thr Leu Glu Ile Asn 
385                 390                 395                 400 


Val Arg Ala Arg Thr Gly Leu Val Ser Asp Met Gly Ile Phe Asp Gln 
                405                 410                 415     


Ile Met Ser Thr Gly Gly Gly Gly His Val Gln Leu Leu Lys Gln Ala 
            420                 425                 430         


Gly Ala Phe Leu Thr Tyr Ser Ser Phe Cys Pro Pro Asp Asp Leu Ala 
        435                 440                 445             


Asp Arg Gly Leu Leu Gly Val Lys Ser Ser Phe Tyr Ala Gln Asp Ala 
    450                 455                 460                 


Leu Arg Leu Trp Glu Ile Ile Tyr Arg Tyr Val Glu Gly Ile Val Ser 
465                 470                 475                 480 


Leu His Tyr Lys Thr Asp Val Ala Val Lys Asp Asp Pro Glu Leu Gln 
                485                 490                 495     


Thr Trp Cys Arg Glu Ile Thr Glu Ile Gly Leu Gln Gly Ala Gln Asp 
            500                 505                 510         


Arg Gly Phe Pro Val Ser Leu Gln Ala Arg Asp Gln Val Cys His Phe 
        515                 520                 525             


Val Thr Met Cys Ile Phe Thr Cys Thr Gly Gln His Ala Ser Val His 
    530                 535                 540                 


Leu Gly Gln Leu Asp Trp Tyr Ser Trp Val Pro Asn Ala Pro Cys Thr 
545                 550                 555                 560 


Met Arg Leu Pro Pro Pro Thr Thr Lys Asp Ala Thr Leu Glu Thr Val 
                565                 570                 575     


Met Ala Thr Leu Pro Asn Phe His Gln Ala Ser Leu Gln Met Ser Ile 
            580                 585                 590         


Thr Trp Gln Leu Gly Arg Arg Gln Pro Val Met Val Ala Val Gly Gln 
        595                 600                 605             


His Glu Glu Glu Tyr Phe Ser Gly Pro Glu Pro Lys Ala Val Leu Lys 
    610                 615                 620                 


Lys Phe Arg Glu Glu Leu Ala Ala Leu Asp Lys Glu Ile Glu Ile Arg 
625                 630                 635                 640 


Asn Ala Lys Leu Asp Met Pro Tyr Glu Tyr Leu Arg Pro Ser Val Val 
                645                 650                 655     


Glu Asn Ser Val Ala Ile 
            660         


<210> 32
<211> 2707
<212> DNA
<213> Homo sapiens

<400> 32
catctttgag caagatgggt ctctaccgca tccgcgtgtc cactggggcc tcgctctatg       60

ccggttccaa caaccaggtg cagctgtggc tggtcggcca gcacggggag gcggcgctcg      120

ggaagcgact gtggcccgca cggggcaagg agacagaact caaggtggaa gtaccggagt      180

atctggggcc gctgctgttt gtgaaactgc gcaaacggca cctccttaag gacgacgcct      240

ggttctgcaa ctggatctct gtgcagggcc ccggagccgg ggacgaggtc aggttccctt      300

gttaccgctg ggtggagggc aacggcgtcc tgagcctgcc tgaaggcacc ggccgcactg      360

tgggcgagga ccctcagggc ctgttccaga aacaccggga agaagagctg gaagagagaa      420

ggaagttgta ccggtgggga aactggaagg acgggttaat tctgaatatg gctggggcca      480

aactatatga cctccctgtg gatgagcgat ttctggaaga caagagagtt gactttgagg      540

tttcgctggc caaggggctg gccgacctcg ctatcaaaga ctctctaaat gttctgactt      600

gctggaagga tctagatgac ttcaaccgga ttttctggtg tggtcagagc aagctggctg      660

agcgcgtgcg ggactcctgg aaggaagatg ccttatttgg gtaccagttt cttaatggcg      720

ccaaccccgt ggtgctgagg cgctctgctc accttcctgc tcgcctagtg ttccctccag      780

gcatggagga actgcaggcc cagctggaga aggagctgga gggaggcaca ctgttcgaag      840

ctgacttctc cctgctggat gggatcaagg ccaacgtcat tctctgtagc cagcagcacc      900

tggctgcccc tctagtcatg ctgaaattgc agcctgatgg gaaactcttg cccatggtca      960

tccagctcca gctgccccgc acaggatccc caccacctcc ccttttcttg cctacggatc     1020

ccccaatggc ctggcttctg gccaaatgct gggtgcgcag ctctgacttc cagctccatg     1080

agctgcagtc tcatcttctg aggggacact tgatggctga ggtcattgtt gtggccacca     1140

tgaggtgcct gccgtcgata catcctatct tcaagcttat aattccccac ctgcgataca     1200

ccctggaaat taacgtccgg gccaggactg ggctggtctc tgacatggga attttcgacc     1260

agataatgag cactggtggg ggaggccacg tgcagctgct caagcaagct ggagccttcc     1320

taacctacag ctccttctgt ccccctgatg acttggccga ccgggggctc ctgggagtga     1380

agtcttcctt ctatgcccaa gatgcgctgc ggctctggga aatcatctat cggtatgtgg     1440

aaggaatcgt gagtctccac tataagacag acgtggctgt gaaagacgac ccagagctgc     1500

agacctggtg tcgagagatc actgaaatcg ggctgcaagg ggcccaggac cgagggtttc     1560

ctgtctcttt acaggctcgg gaccaggttt gccactttgt caccatgtgt atcttcacct     1620

gcaccggcca acacgcctct gtgcacctgg gccagctgga ctggtactct tgggtgccta     1680

atgcaccctg cacgatgcgg ctgcccccgc caaccaccaa ggatgcaacg ctggagacag     1740

tgatggcgac actgcccaac ttccaccagg cttctctcca gatgtccatc acttggcagc     1800

tgggcagacg ccagcccgtt atggtggctg tgggccagca tgaggaggag tatttttcgg     1860

gccctgagcc taaggctgtg ctgaagaagt tcagggagga gctggctgcc ctggataagg     1920

aaattgagat ccggaatgca aagctggaca tgccctacga gtacctgcgg cccagcgtgg     1980

tggaaaacag tgtggccatc taagcgtcgc caccctttgg ttatttcagc ccccatcacc     2040

caagccacaa gctgacccct tcgtggttat agccctgccc tcccaagtcc caccctcttc     2100

ccatgtccca ccctccctag aggggcacct tttcatggtc tctgcaccca gtgaacacat     2160

tttactctag aggcatcacc tgggacctta ctcctctttc cttccttcct cctttcctat     2220

cttccttcct ctctctcttc ctctttcttc attcagatct atatggcaaa tagccacaat     2280

tatataaatc atttcaagac tagaataggg ggatataata catattactc cacacctttt     2340

atgaatcaaa tatgattttt ttgttgttgt taagacagag tctcactttg acacccaggc     2400

tggagtgcag tggtgccatc accacggctc actgcagcct cagcgtcctg ggctcaaatg     2460

atcctcccac ctcagcctcc tgagtagctg ggactacagg ctcatgccat catgcccagc     2520

taatattttt ttattttcgt ggagacgggg cctcactatg ttgcctaggc tggaaatagg     2580

attttgaacc caaattgagt ttaacaataa taaaaagttg ttttacgcta aagatggaaa     2640

agaactagga ctgaactatt ttaaataaaa tattggcaaa agaaaaaaaa aaaaaaaaaa     2700

aaaaaaa                                                               2707


<210> 33
<211> 772
<212> PRT
<213> Homo sapiens

<400> 33
Met Asn Cys Tyr Leu Leu Leu Arg Phe Met Leu Gly Ile Pro Leu Leu 
1               5                   10                  15      


Trp Pro Cys Leu Gly Ala Thr Glu Asn Ser Gln Thr Lys Lys Val Lys 
            20                  25                  30          


Gln Pro Val Arg Ser His Leu Arg Val Lys Arg Gly Trp Val Trp Asn 
        35                  40                  45              


Gln Phe Phe Val Pro Glu Glu Met Asn Thr Thr Ser His His Ile Gly 
    50                  55                  60                  


Gln Leu Arg Ser Asp Leu Asp Asn Gly Asn Asn Ser Phe Gln Tyr Lys 
65                  70                  75                  80  


Leu Leu Gly Ala Gly Ala Gly Ser Thr Phe Ile Ile Asp Glu Arg Thr 
                85                  90                  95      


Gly Asp Ile Tyr Ala Ile Gln Lys Leu Asp Arg Glu Glu Arg Ser Leu 
            100                 105                 110         


Tyr Ile Leu Arg Ala Gln Val Ile Asp Ile Ala Thr Gly Arg Ala Val 
        115                 120                 125             


Glu Pro Glu Ser Glu Phe Val Ile Lys Val Ser Asp Ile Asn Asp Asn 
    130                 135                 140                 


Glu Pro Lys Phe Leu Asp Glu Pro Tyr Glu Ala Ile Val Pro Glu Met 
145                 150                 155                 160 


Ser Pro Glu Gly Thr Leu Val Ile Gln Val Thr Ala Ser Asp Ala Asp 
                165                 170                 175     


Asp Pro Ser Ser Gly Asn Asn Ala Arg Leu Leu Tyr Ser Leu Leu Gln 
            180                 185                 190         


Gly Gln Pro Tyr Phe Ser Val Glu Pro Thr Thr Gly Val Ile Arg Ile 
        195                 200                 205             


Ser Ser Lys Met Asp Arg Glu Leu Gln Asp Glu Tyr Trp Val Ile Ile 
    210                 215                 220                 


Gln Ala Lys Asp Met Ile Gly Gln Pro Gly Ala Leu Ser Gly Thr Thr 
225                 230                 235                 240 


Ser Val Leu Ile Lys Leu Ser Asp Val Asn Asp Asn Lys Pro Ile Phe 
                245                 250                 255     


Lys Glu Ser Leu Tyr Arg Leu Thr Val Ser Glu Ser Ala Pro Thr Gly 
            260                 265                 270         


Thr Ser Ile Gly Thr Ile Met Ala Tyr Asp Asn Asp Ile Gly Glu Asn 
        275                 280                 285             


Ala Glu Met Asp Tyr Ser Ile Glu Glu Asp Asp Ser Gln Thr Phe Asp 
    290                 295                 300                 


Ile Ile Thr Asn His Glu Thr Gln Glu Gly Ile Val Ile Leu Lys Lys 
305                 310                 315                 320 


Lys Val Asp Phe Glu His Gln Asn His Tyr Gly Ile Arg Ala Lys Val 
                325                 330                 335     


Lys Asn His His Val Pro Glu Gln Leu Met Lys Tyr His Thr Glu Ala 
            340                 345                 350         


Ser Thr Thr Phe Ile Lys Ile Gln Val Glu Asp Val Asp Glu Pro Pro 
        355                 360                 365             


Leu Phe Leu Leu Pro Tyr Tyr Val Phe Glu Val Phe Glu Glu Thr Pro 
    370                 375                 380                 


Gln Gly Ser Phe Val Gly Val Val Ser Ala Thr Asp Pro Asp Asn Arg 
385                 390                 395                 400 


Lys Ser Pro Ile Arg Tyr Ser Ile Thr Arg Ser Lys Val Phe Asn Ile 
                405                 410                 415     


Asn Asp Asn Gly Thr Ile Thr Thr Ser Asn Ser Leu Asp Arg Glu Ile 
            420                 425                 430         


Ser Ala Trp Tyr Asn Leu Ser Ile Thr Ala Thr Glu Lys Tyr Asn Ile 
        435                 440                 445             


Glu Gln Ile Ser Ser Ile Pro Leu Tyr Val Gln Val Leu Asn Ile Asn 
    450                 455                 460                 


Asp His Ala Pro Glu Phe Ser Gln Tyr Tyr Glu Thr Tyr Val Cys Glu 
465                 470                 475                 480 


Asn Ala Gly Ser Gly Gln Val Ile Gln Thr Ile Ser Ala Val Asp Arg 
                485                 490                 495     


Asp Glu Ser Ile Glu Glu His His Phe Tyr Phe Asn Leu Ser Val Glu 
            500                 505                 510         


Asp Thr Asn Asn Ser Ser Phe Thr Ile Ile Asp Asn Gln Asp Asn Thr 
        515                 520                 525             


Ala Val Ile Leu Thr Asn Arg Thr Gly Phe Asn Leu Gln Glu Glu Pro 
    530                 535                 540                 


Val Phe Tyr Ile Ser Ile Leu Ile Ala Asp Asn Gly Ile Pro Ser Leu 
545                 550                 555                 560 


Thr Ser Thr Asn Thr Leu Thr Ile His Val Cys Asp Cys Gly Asp Ser 
                565                 570                 575     


Gly Ser Thr Gln Thr Cys Gln Tyr Gln Glu Leu Val Leu Ser Met Gly 
            580                 585                 590         


Phe Lys Thr Glu Val Ile Ile Ala Ile Leu Ile Cys Ile Met Ile Ile 
        595                 600                 605             


Phe Gly Phe Ile Phe Leu Thr Leu Gly Leu Lys Gln Arg Arg Lys Gln 
    610                 615                 620                 


Ile Leu Phe Pro Glu Lys Ser Glu Asp Phe Arg Glu Asn Ile Phe Gln 
625                 630                 635                 640 


Tyr Asp Asp Glu Gly Gly Gly Glu Glu Asp Thr Glu Ala Phe Asp Ile 
                645                 650                 655     


Ala Glu Leu Arg Ser Ser Thr Ile Met Arg Glu Arg Lys Thr Arg Lys 
            660                 665                 670         


Thr Thr Ser Ala Glu Ile Arg Ser Leu Tyr Arg Gln Ser Leu Gln Val 
        675                 680                 685             


Gly Pro Asp Ser Ala Ile Phe Arg Lys Phe Ile Leu Glu Lys Leu Glu 
    690                 695                 700                 


Glu Ala Asn Thr Asp Pro Cys Ala Pro Pro Phe Asp Ser Leu Gln Thr 
705                 710                 715                 720 


Tyr Ala Phe Glu Gly Thr Gly Ser Leu Ala Gly Ser Leu Ser Ser Leu 
                725                 730                 735     


Glu Ser Ala Val Ser Asp Gln Asp Glu Ser Tyr Asp Tyr Leu Asn Glu 
            740                 745                 750         


Leu Gly Pro Arg Phe Lys Arg Leu Ala Cys Met Phe Gly Ser Ala Val 
        755                 760                 765             


Gln Ser Asn Asn 
    770         


<210> 34
<211> 6241
<212> DNA
<213> Homo sapiens

<400> 34
atactgacag tgttgtggta ctaaaagcac aagcgtctgt aactctgggc aatggggcac       60

atcgagagtt tgctgagaag actgtgaagc aaaaagaaga aagtttttcc tactcttcct      120

tatgtgtcca acacgaagtt tgctgttcag ttttcacaga acttctagaa gttgaagtta      180

caaaggtata tagaaggtac acagaatcag aaaagattat aaaagaaagc aagatttttg      240

ttagtgacgt cctgtttcct ctgaagagta atagttggaa tcaaaagagt caacgcaatg      300

aactgttatt tactgctgcg ttttatgttg ggaattcctc tcctatggcc ttgtcttgga      360

gcaacagaaa actctcaaac aaagaaagtc aagcagccag tgcgatctca tttgagagtg      420

aagcgtggct gggtgtggaa ccaatttttt gtaccagagg aaatgaatac gactagtcat      480

cacatcggcc agctaagatc tgatttagac aatggaaaca attctttcca gtacaagctt      540

ttgggagctg gagctggaag tacttttatc attgatgaaa gaacaggtga catatatgcc      600

atacagaagc ttgatagaga ggagcgatcc ctctacatct taagagccca ggtaatagac      660

atcgctactg gaagggctgt ggaacctgag tctgagtttg tcatcaaagt ttcggatatc      720

aatgacaatg aaccaaaatt cctagatgaa ccttatgagg ccattgtacc agagatgtct      780

ccagaaggaa cattagttat ccaggtgaca gcaagtgatg ctgacgatcc ctcaagtggt      840

aataatgctc gtctcctcta cagcttactt caaggccagc catatttttc tgttgaacca      900

acaacaggag tcataagaat atcttctaaa atggatagag aactgcaaga tgagtattgg      960

gtaatcattc aagccaagga catgattggt cagccaggag cgttgtctgg aacaacaagt     1020

gtattaatta aactttcaga tgttaatgac aataagccta tatttaaaga aagtttatac     1080

cgcttgactg tctctgaatc tgcacccact gggacttcta taggaacaat catggcatat     1140

gataatgaca taggagagaa tgcagaaatg gattacagca ttgaagagga tgattcgcaa     1200

acatttgaca ttattactaa tcatgaaact caagaaggaa tagttatatt aaaaaagaaa     1260

gtggattttg agcaccagaa ccactacggt attagagcaa aagttaaaaa ccatcatgtt     1320

cctgagcagc tcatgaagta ccacactgag gcttccacca ctttcattaa gatccaggtg     1380

gaagatgttg atgagcctcc tcttttcctc cttccatatt atgtatttga agtttttgaa     1440

gaaaccccac agggatcatt tgtaggcgtg gtgtctgcca cagacccaga caataggaaa     1500

tctcctatca ggtattctat tactaggagc aaagtgttca atatcaatga taatggtaca     1560

atcactacaa gtaactcact ggatcgtgaa atcagtgctt ggtacaacct aagtattaca     1620

gccacagaaa aatacaatat agaacagatc tcttcgatcc cactgtatgt gcaagttctt     1680

aacatcaatg atcatgctcc tgagttctct caatactatg agacttatgt ttgtgaaaat     1740

gcaggctctg gtcaggtaat tcagactatc agtgcagtgg atagagatga atccatagaa     1800

gagcaccatt tttactttaa tctatctgta gaagacacta acaattcaag ttttacaatc     1860

atagataatc aagataacac agctgtcatt ttgactaata gaactggttt taaccttcaa     1920

gaagaacctg tcttctacat ctccatctta attgccgaca atggaatccc gtcacttaca     1980

agtacaaaca cccttaccat ccatgtctgt gactgtggtg acagtgggag cacacagacc     2040

tgccagtacc aggagcttgt gctttccatg ggattcaaga cagaagtcat cattgctatt     2100

ctcatttgca ttatgatcat atttgggttt atttttttga ctttgggttt aaaacaacgg     2160

agaaaacaga ttctatttcc tgagaaaagt gaagatttca gagagaatat attccaatat     2220

gatgatgaag ggggtggaga agaagataca gaggcctttg atatagcaga gctgaggagt     2280

agtaccataa tgcgggaacg caagactcgg aaaaccacaa gcgctgagat caggagccta     2340

tacaggcagt ctttgcaagt tggccccgac agtgccatat tcaggaaatt cattctggaa     2400

aagctcgaag aagctaatac tgatccgtgt gcccctcctt ttgattccct ccagacctac     2460

gcttttgagg gaacagggtc attagctgga tccctgagct ccttagaatc agcagtctct     2520

gatcaggatg aaagctatga ttaccttaat gagttgggac ctcgctttaa aagattagca     2580

tgcatgtttg gttctgcagt gcagtcaaat aattagggct ttttaccatc aaaattttta     2640

aaagtgctaa tgtgtattcg aacccaatgg tagtcttaaa gagttttgtg ccctggctct     2700

atggcgggga aagccctagt ctatggagtt ttctgatttc cctggagtaa atactccatg     2760

gttattttaa gctacctaca tgctgtcatt gaacagagat gtggggagaa atgtaaacaa     2820

tcagctcaca ggcatcaata caaccagatt tgaagtaaaa taatttagga agatattaaa     2880

agtagatgag aggacacaag atgtagtcga tccttatgcg attatatcat tatttactta     2940

ggaaagagta aaaataccaa acgagaaaat ttaaaggagc aaaaatttgc aagtcaaata     3000

gaaatgtaca aatcgagata acatttacat ttctatcata ttgacatgaa aattgaaaat     3060

gtatagtcag agaaattttc atgaattatt ccatgaagta ttgtttcctt tatttaaaaa     3120

aaaaaaaaaa aaaaaagaat gctaggtaat cttcgtagaa aactagaaag tatgataaac     3180

aacagttgga ggaatccatg gaaaatagac gagaaaatgt aaataaggct ttctggggat     3240

cacagaactt ttgtatgaat aaaagcctta taaaaccagc tctggcatat gactaaaata     3300

ttcctctact atttttcaat gtcatctaat gcaaacgctc aaccttttta aatggttaat     3360

gtgagaaagg cactgaatta agatatctta gtgttatttt atttactcaa ttttcatctt     3420

tcacactgta agaataaaat gtttttgtgg ttaagttcct gatactatat agagataaac     3480

tttaaaactt taacacctag gataatgtgg gtgattacat aaatgtttaa aaacatttac     3540

cttatatgga aagcagattt ctgactaaga tgccatgatt cattctagtt tgatatttta     3600

aaactttgcc aagagcactc tttaaaactg atttcaaatt tgaacagata cttggtgtat     3660

acaaattaat cagagttata tagtataaat ttgtattatt tttgatatta caactttgta     3720

ttaaaaagga aaatatattt aggtgtttgt catagatttt ttttcatatg caactcaaaa     3780

cacattctta tgtcaaaata caatagcaaa atacaagtca atatttactc ataattaaat     3840

gcaaacttta tgaaactggt ggaaagtgtg gaaaaattta agtaaatttt tacctctact     3900

aaaaattatt tagacaactt aaaggaatac tggattcaaa cttcagttac tattcactgt     3960

aaatattatg atcaactgaa ctgacttacc attcatggga taaaacatga tacaattctc     4020

agtatttgct tttctgttaa gagcttggaa tatgactgat gcttcagtgt cattttttta     4080

ttattgaata taaaattagg tgcaatagat acatttattg tagccttaag aaggaaatca     4140

atgctaagct gttgggcata aaactttaca gtaacattag ataacaagat aataaaacac     4200

tttaatttta atcgaccttt taagaatgat ctttattatt ctatccaaat caaggtagac     4260

ttcaaaattt atggtttgaa caggaagaaa gtagtgaata caaaattctt aaaattggtt     4320

catatgatca tttttttatt aatagcatgt gagactaagc tgaaccaaac tggccatata     4380

tgttaaatca aataatttga gtaattttga aatattgatg aagtagttaa atggttataa     4440

tatattttat tggtactttg aaatttaaac atctatatca cataataaag aaagtttttc     4500

atcaatctga aacaggcacc attaaattgg tgacacaaat attatcattt cacaaaagct     4560

tgagaaaacc agatttgaag tgaaataatt taggaagata ttaaaagtgg atgagaggac     4620

ataagatgta gtcaatcctt aacgcaatga taccattatt aggaaagagg aaaaatacca     4680

aacaagagaa aatttaaagg agcaaaaatt tgcaagtcaa atagaaatgc acaaatcgag     4740

agaacattta catttctatc acattgacat gaaaattgaa aatgtatagt cagagaaatt     4800

ttcatgaatt attccatgaa gtgttgtttc ctttatttaa aaagaatgct aggtaatctt     4860

agtagaaaac taaaaagtat gataaacaac agatggaaga attcatggaa aatagacgag     4920

aaaaagtaaa taaggctttc tggagatgac ggaaattttg tatgaataaa agccttataa     4980

acaatgaata catttggata aacaactcat taaaatgcac attaatggaa tacctgtaca     5040

aatagtttta atacttgtgt ccagtggcac taaagagata tattaaaata gattctggtt     5100

gagttgatta taagattgtc aatcatagga tacacaggga aagcacagac acgattgctc     5160

atctctttgg tagtctaaaa tatgttcctt ttaaccacat caaaagatac tatctgattc     5220

taatacagaa ggtgcaactt cctaggaatt atactttgta ttatattcaa taattatttt     5280

atgttttgca tcacatgggt gttgcaagaa cacagctctt aaactaaaaa ggcattacat     5340

taagaattta tttttgtaaa ttttaataaa ctctaaatta atgcaaaata tttatgaaaa     5400

tagcacagct tcacattaat acccacagta cttaaatatc tcccttagtt gactcacagc     5460

tttgtatgta agcttcaaat ttttaatggt aaaaataaga aaattaggac tagcgaactg     5520

ctagttgttc cctcagtgca tgtgcttgag cctaacagat ctttgtttga attagttact     5580

ttcaattaag cgaacatata atatttgtta aactgcttaa tctttccaga tctcactttg     5640

taaaatgacg tccaatcaac ctatttcaca tggttgttat gaagaattaa taataagata     5700

tgtaaaacca gcagcaccaa tagtgcctga caaaatataa ctgctcaata aataacagtg     5760

aattattata acaacagcta atggtattct attggaacac atggtctgtt tcttttccaa     5820

ttctgagtga tctcaacagc ctcacggcac attgaaaata aaagtcaact tcctcacctt     5880

ccccataggc catggacttt cccatctcta cccacttgtg cagtttctcc tctttcctct     5940

ctcctcctca gttactaaag caatcttcct tcaaacactt ctattttcca ttacatcact     6000

tcattcaggt tggtgatcag ctgcaacttc ctcagaaaga ccactgctgc ttccagtgac     6060

cctggctttg tcttgctttg tattagatta ctcagctccc tggtattatt gttgtcttta     6120

tcgcttatta gaatgtaacc cttaatgggc aagaaattgt cagtcttgtt catttatcat     6180

cgtataaaaa atgtttctag cacacagaaa gtgaccaata aatatttctg gaattaatgt     6240

a                                                                     6241


<210> 35
<211> 320
<212> PRT
<213> Homo sapiens

<400> 35
Met Ser Ser Cys Asn Phe Thr His Ala Thr Phe Val Leu Ile Gly Ile 
1               5                   10                  15      


Pro Gly Leu Glu Lys Ala His Phe Trp Val Gly Phe Pro Leu Leu Ser 
            20                  25                  30          


Met Tyr Val Val Ala Met Phe Gly Asn Cys Ile Val Val Phe Ile Val 
        35                  40                  45              


Arg Thr Glu Arg Ser Leu His Ala Pro Met Tyr Leu Phe Leu Cys Met 
    50                  55                  60                  


Leu Ala Ala Ile Asp Leu Ala Leu Ser Thr Ser Thr Met Pro Lys Ile 
65                  70                  75                  80  


Leu Ala Leu Phe Trp Phe Asp Ser Arg Glu Ile Ser Phe Glu Ala Cys 
                85                  90                  95      


Leu Thr Gln Met Phe Phe Ile His Ala Leu Ser Ala Ile Glu Ser Thr 
            100                 105                 110         


Ile Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile Cys His Pro 
        115                 120                 125             


Leu Arg His Ala Ala Val Leu Asn Asn Thr Val Thr Ala Gln Ile Gly 
    130                 135                 140                 


Ile Val Ala Val Val Arg Gly Ser Leu Phe Phe Phe Pro Leu Pro Leu 
145                 150                 155                 160 


Leu Ile Lys Arg Leu Ala Phe Cys His Ser Asn Val Leu Ser His Ser 
                165                 170                 175     


Tyr Cys Val His Gln Asp Val Met Lys Leu Ala Tyr Ala Asp Thr Leu 
            180                 185                 190         


Pro Asn Val Val Tyr Gly Leu Thr Ala Ile Leu Leu Val Met Gly Val 
        195                 200                 205             


Asp Val Met Phe Ile Ser Leu Ser Tyr Phe Leu Ile Ile Arg Thr Val 
    210                 215                 220                 


Leu Gln Leu Pro Ser Lys Ser Glu Arg Ala Lys Ala Phe Gly Thr Cys 
225                 230                 235                 240 


Val Ser His Ile Gly Val Val Leu Ala Phe Tyr Val Pro Leu Ile Gly 
                245                 250                 255     


Leu Ser Val Val His Arg Phe Gly Asn Ser Leu His Pro Ile Val Arg 
            260                 265                 270         


Val Val Met Gly Asp Ile Tyr Leu Leu Leu Pro Pro Val Ile Asn Pro 
        275                 280                 285             


Ile Ile Tyr Gly Ala Lys Thr Lys Gln Ile Arg Thr Arg Val Leu Ala 
    290                 295                 300                 


Met Phe Lys Ile Ser Cys Asp Lys Asp Leu Gln Ala Val Gly Gly Lys 
305                 310                 315                 320 


<210> 36
<211> 2799
<212> DNA
<213> Homo sapiens

<400> 36
ctcacacacc ctgaagacac agtgagttag caccaccacc aggaattggc cttttagctc       60

tgtgcctgtc tccagtcagg ctggaataag tctcctcata tttgcaagct cggccctccc      120

ctggaatcta aagcctcctc agccttctga gtcagcctga aaggaacagg ccgaactgct      180

gtatgggctc tactgccagt gtgacctcac cctctccagt cacccctcct cagttccagc      240

tatgagttcc tgcaacttca cacatgccac ctttgtgctt attggtatcc caggattaga      300

gaaagcccat ttctgggttg gcttccccct cctttccatg tatgtagtgg caatgtttgg      360

aaactgcatc gtggtcttca tcgtaaggac ggaacgcagc ctgcacgctc cgatgtacct      420

ctttctctgc atgcttgcag ccattgacct ggccttatcc acatccacca tgcctaagat      480

ccttgccctt ttctggtttg attcccgaga gattagcttt gaggcctgtc ttacccagat      540

gttctttatt catgccctct cagccattga atccaccatc ctgctggcca tggcctttga      600

ccgttatgtg gccatctgcc acccactgcg ccatgctgca gtgctcaaca atacagtaac      660

agcccagatt ggcatcgtgg ctgtggtccg cggatccctc ttttttttcc cactgcctct      720

gctgatcaag cggctggcct tctgccactc caatgtcctc tcgcactcct attgtgtcca      780

ccaggatgta atgaagttgg cctatgcaga cactttgccc aatgtggtat atggtcttac      840

tgccattctg ctggtcatgg gcgtggacgt aatgttcatc tccttgtcct attttctgat      900

aatacgaacg gttctgcaac tgccttccaa gtcagagcgg gccaaggcct ttggaacctg      960

tgtgtcacac attggtgtgg tactcgcctt ctatgtgcca cttattggcc tctcagttgt     1020

acaccgcttt ggaaacagcc ttcatcccat tgtgcgtgtt gtcatgggtg acatctacct     1080

gctgctgcct cctgtcatca atcccatcat ctatggtgcc aaaaccaaac agatcagaac     1140

acgggtgctg gctatgttca agatcagctg tgacaaggac ttgcaggctg tgggaggcaa     1200

gtgaccctta acactacact tctccttatc tttattggct tgataaacat aattatttct     1260

aacactagct tatttccagt tgcccataag cacatcagta cttttctctg gctggaatag     1320

taaactaaag tatggtacat ctacctaaag gactattatg tggaataata catactaatg     1380

aagtattaca tgatttaaag actacaataa aaccaaacat gcttataaca ttaagaaaaa     1440

caataaagat acatgattga aaccaagttg aaaaatagca tatgccttgg aggaaatgtg     1500

ctcaaattac taatgattta gtgttgtccc tactttctct ctcttttttc tttctttttt     1560

ttttattatg gttagctgtc acatacaact tttttttttt tgagatgggg tctcgctctg     1620

tcaccaggct ggagtgcagt ggcgcgatct cggctcactg caacctccac atcccatgtt     1680

gaagtaattc ttctgcctca gcctcccgag tagctgggac tagaggaacg tgccaccatg     1740

actggctaat tttctgtatt ttttagtaga gacagagttt caccatgttg gccaggatgg     1800

tctcgatctc ctgaccttgt gatccacccg cctcagcctc ccaaagtgtt gggattacag     1860

gtgtgaacca ctgtgcccgg cctgtgtaca actttttaaa tagggaatat gatagcttcg     1920

catggtggtg tgcacctata gcccccactg cctggaaagc tgaggtggga gaatcgcttg     1980

agtccaggag tttgaggtta cagtgatcca cgatcgtacc actacactcc agcctgggca     2040

acggagcaag accctgtctc aaagcataaa atggaataac atatcaaatg aaacagggaa     2100

aatgaagctg acaatttatg gaagccaggg cttgtcacag tctctactgt tattatgcat     2160

tacctgggaa tttatataag cccttaataa taatgccaat gaacatctca tgtgtgctca     2220

caatgttctg gcactattat aagtgcttca caggttttat gtgttcttcg taactttatg     2280

gagtaggtac catttgtgtc tctttattat aagtgagaga aatgaagttt atattatcaa     2340

ggggactaaa gtcacacggc ttgtgggcac tgtgccaaga tttaaaatta aatttgatgg     2400

ttgaatacag ttacttaatg accatgttat attgcttcct gtgtaacatc tgccatttat     2460

ttcctcagct gtacaaatcc tctgttttct ctctgttaca cactaacatc aatggctttg     2520

tacttgtgat gagagataac cttgccctag ttgtgggcaa cacatgcaga ataatcctgt     2580

tttacagctg cctttcgtga tcttattgct tgcttttttc cagattcagg gagaatgttg     2640

ttgtctattt gtctcttaca tctccttgat catgtcttca ttttttaatg tgctctgtac     2700

ctgtcaaaaa ttttgaatgt acaccacatg ctattgtctg aacctgagta taagataaaa     2760

taaaatttta ttttaaattt taaaaaaaaa aaaaaaaaa                            2799


<210> 37
<211> 2224
<212> PRT
<213> Homo sapiens

<400> 37
Met Phe Pro Gly Cys Pro Arg Leu Trp Val Leu Val Val Leu Gly Thr 
1               5                   10                  15      


Ser Trp Val Gly Trp Gly Ser Gln Gly Thr Glu Ala Ala Gln Leu Arg 
            20                  25                  30          


Gln Phe Tyr Val Ala Ala Gln Gly Ile Ser Trp Ser Tyr Arg Pro Glu 
        35                  40                  45              


Pro Thr Asn Ser Ser Leu Asn Leu Ser Val Thr Ser Phe Lys Lys Ile 
    50                  55                  60                  


Val Tyr Arg Glu Tyr Glu Pro Tyr Phe Lys Lys Glu Lys Pro Gln Ser 
65                  70                  75                  80  


Thr Ile Ser Gly Leu Leu Gly Pro Thr Leu Tyr Ala Glu Val Gly Asp 
                85                  90                  95      


Ile Ile Lys Val His Phe Lys Asn Lys Ala Asp Lys Pro Leu Ser Ile 
            100                 105                 110         


His Pro Gln Gly Ile Arg Tyr Ser Lys Leu Ser Glu Gly Ala Ser Tyr 
        115                 120                 125             


Leu Asp His Thr Phe Pro Ala Glu Lys Met Asp Asp Ala Val Ala Pro 
    130                 135                 140                 


Gly Arg Glu Tyr Thr Tyr Glu Trp Ser Ile Ser Glu Asp Ser Gly Pro 
145                 150                 155                 160 


Thr His Asp Asp Pro Pro Cys Leu Thr His Ile Tyr Tyr Ser His Glu 
                165                 170                 175     


Asn Leu Ile Glu Asp Phe Asn Ser Gly Leu Ile Gly Pro Leu Leu Ile 
            180                 185                 190         


Cys Lys Lys Gly Thr Leu Thr Glu Gly Gly Thr Gln Lys Thr Phe Asp 
        195                 200                 205             


Lys Gln Ile Val Leu Leu Phe Ala Val Phe Asp Glu Ser Lys Ser Trp 
    210                 215                 220                 


Ser Gln Ser Ser Ser Leu Met Tyr Thr Val Asn Gly Tyr Val Asn Gly 
225                 230                 235                 240 


Thr Met Pro Asp Ile Thr Val Cys Ala His Asp His Ile Ser Trp His 
                245                 250                 255     


Leu Leu Gly Met Ser Ser Gly Pro Glu Leu Phe Ser Ile His Phe Asn 
            260                 265                 270         


Gly Gln Val Leu Glu Gln Asn His His Lys Val Ser Ala Ile Thr Leu 
        275                 280                 285             


Val Ser Ala Thr Ser Thr Thr Ala Asn Met Thr Val Gly Pro Glu Gly 
    290                 295                 300                 


Lys Trp Ile Ile Ser Ser Leu Thr Pro Lys His Leu Gln Ala Gly Met 
305                 310                 315                 320 


Gln Ala Tyr Ile Asp Ile Lys Asn Cys Pro Lys Lys Thr Arg Asn Leu 
                325                 330                 335     


Lys Lys Ile Thr Arg Glu Gln Arg Arg His Met Lys Arg Trp Glu Tyr 
            340                 345                 350         


Phe Ile Ala Ala Glu Glu Val Ile Trp Asp Tyr Ala Pro Val Ile Pro 
        355                 360                 365             


Ala Asn Met Asp Lys Lys Tyr Arg Ser Gln His Leu Asp Asn Phe Ser 
    370                 375                 380                 


Asn Gln Ile Gly Lys His Tyr Lys Lys Val Met Tyr Thr Gln Tyr Glu 
385                 390                 395                 400 


Asp Glu Ser Phe Thr Lys His Thr Val Asn Pro Asn Met Lys Glu Asp 
                405                 410                 415     


Gly Ile Leu Gly Pro Ile Ile Arg Ala Gln Val Arg Asp Thr Leu Lys 
            420                 425                 430         


Ile Val Phe Lys Asn Met Ala Ser Arg Pro Tyr Ser Ile Tyr Pro His 
        435                 440                 445             


Gly Val Thr Phe Ser Pro Tyr Glu Asp Glu Val Asn Ser Ser Phe Thr 
    450                 455                 460                 


Ser Gly Arg Asn Asn Thr Met Ile Arg Ala Val Gln Pro Gly Glu Thr 
465                 470                 475                 480 


Tyr Thr Tyr Lys Trp Asn Ile Leu Glu Phe Asp Glu Pro Thr Glu Asn 
                485                 490                 495     


Asp Ala Gln Cys Leu Thr Arg Pro Tyr Tyr Ser Asp Val Asp Ile Met 
            500                 505                 510         


Arg Asp Ile Ala Ser Gly Leu Ile Gly Leu Leu Leu Ile Cys Lys Ser 
        515                 520                 525             


Arg Ser Leu Asp Arg Arg Gly Ile Gln Arg Ala Ala Asp Ile Glu Gln 
    530                 535                 540                 


Gln Ala Val Phe Ala Val Phe Asp Glu Asn Lys Ser Trp Tyr Leu Glu 
545                 550                 555                 560 


Asp Asn Ile Asn Lys Phe Cys Glu Asn Pro Asp Glu Val Lys Arg Asp 
                565                 570                 575     


Asp Pro Lys Phe Tyr Glu Ser Asn Ile Met Ser Thr Ile Asn Gly Tyr 
            580                 585                 590         


Val Pro Glu Ser Ile Thr Thr Leu Gly Phe Cys Phe Asp Asp Thr Val 
        595                 600                 605             


Gln Trp His Phe Cys Ser Val Gly Thr Gln Asn Glu Ile Leu Thr Ile 
    610                 615                 620                 


His Phe Thr Gly His Ser Phe Ile Tyr Gly Lys Arg His Glu Asp Thr 
625                 630                 635                 640 


Leu Thr Leu Phe Pro Met Arg Gly Glu Ser Val Thr Val Thr Met Asp 
                645                 650                 655     


Asn Val Gly Thr Trp Met Leu Thr Ser Met Asn Ser Ser Pro Arg Ser 
            660                 665                 670         


Lys Lys Leu Arg Leu Lys Phe Arg Asp Val Lys Cys Ile Pro Asp Asp 
        675                 680                 685             


Asp Glu Asp Ser Tyr Glu Ile Phe Glu Pro Pro Glu Ser Thr Val Met 
    690                 695                 700                 


Ala Thr Arg Lys Met His Asp Arg Leu Glu Pro Glu Asp Glu Glu Ser 
705                 710                 715                 720 


Asp Ala Asp Tyr Asp Tyr Gln Asn Arg Leu Ala Ala Ala Leu Gly Ile 
                725                 730                 735     


Arg Ser Phe Arg Asn Ser Ser Leu Asn Gln Glu Glu Glu Glu Phe Asn 
            740                 745                 750         


Leu Thr Ala Leu Ala Leu Glu Asn Gly Thr Glu Phe Val Ser Ser Asn 
        755                 760                 765             


Thr Asp Ile Ile Val Gly Ser Asn Tyr Ser Ser Pro Ser Asn Ile Ser 
    770                 775                 780                 


Lys Phe Thr Val Asn Asn Leu Ala Glu Pro Gln Lys Ala Pro Ser His 
785                 790                 795                 800 


Gln Gln Ala Thr Thr Ala Gly Ser Pro Leu Arg His Leu Ile Gly Lys 
                805                 810                 815     


Asn Ser Val Leu Asn Ser Ser Thr Ala Glu His Ser Ser Pro Tyr Ser 
            820                 825                 830         


Glu Asp Pro Ile Glu Asp Pro Leu Gln Pro Asp Val Thr Gly Ile Arg 
        835                 840                 845             


Leu Leu Ser Leu Gly Ala Gly Glu Phe Lys Ser Gln Glu His Ala Lys 
    850                 855                 860                 


His Lys Gly Pro Lys Val Glu Arg Asp Gln Ala Ala Lys His Arg Phe 
865                 870                 875                 880 


Ser Trp Met Lys Leu Leu Ala His Lys Val Gly Arg His Leu Ser Gln 
                885                 890                 895     


Asp Thr Gly Ser Pro Ser Gly Met Arg Pro Trp Glu Asp Leu Pro Ser 
            900                 905                 910         


Gln Asp Thr Gly Ser Pro Ser Arg Met Arg Pro Trp Lys Asp Pro Pro 
        915                 920                 925             


Ser Asp Leu Leu Leu Leu Lys Gln Ser Asn Ser Ser Lys Ile Leu Val 
    930                 935                 940                 


Gly Arg Trp His Leu Ala Ser Glu Lys Gly Ser Tyr Glu Ile Ile Gln 
945                 950                 955                 960 


Asp Thr Asp Glu Asp Thr Ala Val Asn Asn Trp Leu Ile Ser Pro Gln 
                965                 970                 975     


Asn Ala Ser Arg Ala Trp Gly Glu Ser Thr Pro Leu Ala Asn Lys Pro 
            980                 985                 990         


Gly Lys Gln Ser Gly His Pro Lys  Phe Pro Arg Val Arg  His Lys Ser 
        995                 1000                 1005             


Leu Gln  Val Arg Gln Asp Gly  Gly Lys Ser Arg Leu  Lys Lys Ser 
    1010                 1015                 1020             


Gln Phe  Leu Ile Lys Thr Arg  Lys Lys Lys Lys Glu  Lys His Thr 
    1025                 1030                 1035             


His His  Ala Pro Leu Ser Pro  Arg Thr Phe His Pro  Leu Arg Ser 
    1040                 1045                 1050             


Glu Ala  Tyr Asn Thr Phe Ser  Glu Arg Arg Leu Lys  His Ser Leu 
    1055                 1060                 1065             


Val Leu  His Lys Ser Asn Glu  Thr Ser Leu Pro Thr  Asp Leu Asn 
    1070                 1075                 1080             


Gln Thr  Leu Pro Ser Met Asp  Phe Gly Trp Ile Ala  Ser Leu Pro 
    1085                 1090                 1095             


Asp His  Asn Gln Asn Ser Ser  Asn Asp Thr Gly Gln  Ala Ser Cys 
    1100                 1105                 1110             


Pro Pro  Gly Leu Tyr Gln Thr  Val Pro Pro Glu Glu  His Tyr Gln 
    1115                 1120                 1125             


Thr Phe  Pro Ile Gln Asp Pro  Asp Gln Met His Ser  Thr Ser Asp 
    1130                 1135                 1140             


Pro Ser  His Arg Ser Ser Ser  Pro Glu Leu Ser Glu  Met Leu Glu 
    1145                 1150                 1155             


Tyr Asp  Arg Ser His Lys Ser  Phe Pro Thr Asp Ile  Ser Gln Met 
    1160                 1165                 1170             


Ser Pro  Ser Ser Glu His Glu  Val Trp Gln Thr Val  Ile Ser Pro 
    1175                 1180                 1185             


Asp Leu  Ser Gln Val Thr Leu  Ser Pro Glu Leu Ser  Gln Thr Asn 
    1190                 1195                 1200             


Leu Ser  Pro Asp Leu Ser His  Thr Thr Leu Ser Pro  Glu Leu Ile 
    1205                 1210                 1215             


Gln Arg  Asn Leu Ser Pro Ala  Leu Gly Gln Met Pro  Ile Ser Pro 
    1220                 1225                 1230             


Asp Leu  Ser His Thr Thr Leu  Ser Pro Asp Leu Ser  His Thr Thr 
    1235                 1240                 1245             


Leu Ser  Leu Asp Leu Ser Gln  Thr Asn Leu Ser Pro  Glu Leu Ser 
    1250                 1255                 1260             


Gln Thr  Asn Leu Ser Pro Ala  Leu Gly Gln Met Pro  Leu Ser Pro 
    1265                 1270                 1275             


Asp Leu  Ser His Thr Thr Leu  Ser Leu Asp Phe Ser  Gln Thr Asn 
    1280                 1285                 1290             


Leu Ser  Pro Glu Leu Ser His  Met Thr Leu Ser Pro  Glu Leu Ser 
    1295                 1300                 1305             


Gln Thr  Asn Leu Ser Pro Ala  Leu Gly Gln Met Pro  Ile Ser Pro 
    1310                 1315                 1320             


Asp Leu  Ser His Thr Thr Leu  Ser Leu Asp Phe Ser  Gln Thr Asn 
    1325                 1330                 1335             


Leu Ser  Pro Glu Leu Ser Gln  Thr Asn Leu Ser Pro  Ala Leu Gly 
    1340                 1345                 1350             


Gln Met  Pro Leu Ser Pro Asp  Pro Ser His Thr Thr  Leu Ser Leu 
    1355                 1360                 1365             


Asp Leu  Ser Gln Thr Asn Leu  Ser Pro Glu Leu Ser  Gln Thr Asn 
    1370                 1375                 1380             


Leu Ser  Pro Asp Leu Ser Glu  Met Pro Leu Phe Ala  Asp Leu Ser 
    1385                 1390                 1395             


Gln Ile  Pro Leu Thr Pro Asp  Leu Asp Gln Met Thr  Leu Ser Pro 
    1400                 1405                 1410             


Asp Leu  Gly Glu Thr Asp Leu  Ser Pro Asn Phe Gly  Gln Met Ser 
    1415                 1420                 1425             


Leu Ser  Pro Asp Leu Ser Gln  Val Thr Leu Ser Pro  Asp Ile Ser 
    1430                 1435                 1440             


Asp Thr  Thr Leu Leu Pro Asp  Leu Ser Gln Ile Ser  Pro Pro Pro 
    1445                 1450                 1455             


Asp Leu  Asp Gln Ile Phe Tyr  Pro Ser Glu Ser Ser  Gln Ser Leu 
    1460                 1465                 1470             


Leu Leu  Gln Glu Phe Asn Glu  Ser Phe Pro Tyr Pro  Asp Leu Gly 
    1475                 1480                 1485             


Gln Met  Pro Ser Pro Ser Ser  Pro Thr Leu Asn Asp  Thr Phe Leu 
    1490                 1495                 1500             


Ser Lys  Glu Phe Asn Pro Leu  Val Ile Val Gly Leu  Ser Lys Asp 
    1505                 1510                 1515             


Gly Thr  Asp Tyr Ile Glu Ile  Ile Pro Lys Glu Glu  Val Gln Ser 
    1520                 1525                 1530             


Ser Glu  Asp Asp Tyr Ala Glu  Ile Asp Tyr Val Pro  Tyr Asp Asp 
    1535                 1540                 1545             


Pro Tyr  Lys Thr Asp Val Arg  Thr Asn Ile Asn Ser  Ser Arg Asp 
    1550                 1555                 1560             


Pro Asp  Asn Ile Ala Ala Trp  Tyr Leu Arg Ser Asn  Asn Gly Asn 
    1565                 1570                 1575             


Arg Arg  Asn Tyr Tyr Ile Ala  Ala Glu Glu Ile Ser  Trp Asp Tyr 
    1580                 1585                 1590             


Ser Glu  Phe Val Gln Arg Glu  Thr Asp Ile Glu Asp  Ser Asp Asp 
    1595                 1600                 1605             


Ile Pro  Glu Asp Thr Thr Tyr  Lys Lys Val Val Phe  Arg Lys Tyr 
    1610                 1615                 1620             


Leu Asp  Ser Thr Phe Thr Lys  Arg Asp Pro Arg Gly  Glu Tyr Glu 
    1625                 1630                 1635             


Glu His  Leu Gly Ile Leu Gly  Pro Ile Ile Arg Ala  Glu Val Asp 
    1640                 1645                 1650             


Asp Val  Ile Gln Val Arg Phe  Lys Asn Leu Ala Ser  Arg Pro Tyr 
    1655                 1660                 1665             


Ser Leu  His Ala His Gly Leu  Ser Tyr Glu Lys Ser  Ser Glu Gly 
    1670                 1675                 1680             


Lys Thr  Tyr Glu Asp Asp Ser  Pro Glu Trp Phe Lys  Glu Asp Asn 
    1685                 1690                 1695             


Ala Val  Gln Pro Asn Ser Ser  Tyr Thr Tyr Val Trp  His Ala Thr 
    1700                 1705                 1710             


Glu Arg  Ser Gly Pro Glu Ser  Pro Gly Ser Ala Cys  Arg Ala Trp 
    1715                 1720                 1725             


Ala Tyr  Tyr Ser Ala Val Asn  Pro Glu Lys Asp Ile  His Ser Gly 
    1730                 1735                 1740             


Leu Ile  Gly Pro Leu Leu Ile  Cys Gln Lys Gly Ile  Leu His Lys 
    1745                 1750                 1755             


Asp Ser  Asn Met Pro Met Asp  Met Arg Glu Phe Val  Leu Leu Phe 
    1760                 1765                 1770             


Met Thr  Phe Asp Glu Lys Lys  Ser Trp Tyr Tyr Glu  Lys Lys Ser 
    1775                 1780                 1785             


Arg Ser  Ser Trp Arg Leu Thr  Ser Ser Glu Met Lys  Lys Ser His 
    1790                 1795                 1800             


Glu Phe  His Ala Ile Asn Gly  Met Ile Tyr Ser Leu  Pro Gly Leu 
    1805                 1810                 1815             


Lys Met  Tyr Glu Gln Glu Trp  Val Arg Leu His Leu  Leu Asn Ile 
    1820                 1825                 1830             


Gly Gly  Ser Gln Asp Ile His  Val Val His Phe His  Gly Gln Thr 
    1835                 1840                 1845             


Leu Leu  Glu Asn Gly Asn Lys  Gln His Gln Leu Gly  Val Trp Pro 
    1850                 1855                 1860             


Leu Leu  Pro Gly Ser Phe Lys  Thr Leu Glu Met Lys  Ala Ser Lys 
    1865                 1870                 1875             


Pro Gly  Trp Trp Leu Leu Asn  Thr Glu Val Gly Glu  Asn Gln Arg 
    1880                 1885                 1890             


Ala Gly  Met Gln Thr Pro Phe  Leu Ile Met Asp Arg  Asp Cys Arg 
    1895                 1900                 1905             


Met Pro  Met Gly Leu Ser Thr  Gly Ile Ile Ser Asp  Ser Gln Ile 
    1910                 1915                 1920             


Lys Ala  Ser Glu Phe Leu Gly  Tyr Trp Glu Pro Arg  Leu Ala Arg 
    1925                 1930                 1935             


Leu Asn  Asn Gly Gly Ser Tyr  Asn Ala Trp Ser Val  Glu Lys Leu 
    1940                 1945                 1950             


Ala Ala  Glu Phe Ala Ser Lys  Pro Trp Ile Gln Val  Asp Met Gln 
    1955                 1960                 1965             


Lys Glu  Val Ile Ile Thr Gly  Ile Gln Thr Gln Gly  Ala Lys His 
    1970                 1975                 1980             


Tyr Leu  Lys Ser Cys Tyr Thr  Thr Glu Phe Tyr Val  Ala Tyr Ser 
    1985                 1990                 1995             


Ser Asn  Gln Ile Asn Trp Gln  Ile Phe Lys Gly Asn  Ser Thr Arg 
    2000                 2005                 2010             


Asn Val  Met Tyr Phe Asn Gly  Asn Ser Asp Ala Ser  Thr Ile Lys 
    2015                 2020                 2025             


Glu Asn  Gln Phe Asp Pro Pro  Ile Val Ala Arg Tyr  Ile Arg Ile 
    2030                 2035                 2040             


Ser Pro  Thr Arg Ala Tyr Asn  Arg Pro Thr Leu Arg  Leu Glu Leu 
    2045                 2050                 2055             


Gln Gly  Cys Glu Val Asn Gly  Cys Ser Thr Pro Leu  Gly Met Glu 
    2060                 2065                 2070             


Asn Gly  Lys Ile Glu Asn Lys  Gln Ile Thr Ala Ser  Ser Phe Lys 
    2075                 2080                 2085             


Lys Ser  Trp Trp Gly Asp Tyr  Trp Glu Pro Phe Arg  Ala Arg Leu 
    2090                 2095                 2100             


Asn Ala  Gln Gly Arg Val Asn  Ala Trp Gln Ala Lys  Ala Asn Asn 
    2105                 2110                 2115             


Asn Lys  Gln Trp Leu Glu Ile  Asp Leu Leu Lys Ile  Lys Lys Ile 
    2120                 2125                 2130             


Thr Ala  Ile Ile Thr Gln Gly  Cys Lys Ser Leu Ser  Ser Glu Met 
    2135                 2140                 2145             


Tyr Val  Lys Ser Tyr Thr Ile  His Tyr Ser Glu Gln  Gly Val Glu 
    2150                 2155                 2160             


Trp Lys  Pro Tyr Arg Leu Lys  Ser Ser Met Val Asp  Lys Ile Phe 
    2165                 2170                 2175             


Glu Gly  Asn Thr Asn Thr Lys  Gly His Val Lys Asn  Phe Phe Asn 
    2180                 2185                 2190             


Pro Pro  Ile Ile Ser Arg Phe  Ile Arg Val Ile Pro  Lys Thr Trp 
    2195                 2200                 2205             


Asn Gln  Ser Ile Ala Leu Arg  Leu Glu Leu Phe Gly  Cys Asp Ile 
    2210                 2215                 2220             


Tyr 
    


<210> 38
<211> 9179
<212> DNA
<213> Homo sapiens

<400> 38
gcaagaactg caggggagga ggacgctgcc acccacagcc tctagagctc attgcagctg       60

ggacagcccg gagtgtggtt agcagctcgg caagcgctgc ccaggtcctg gggtggtggc      120

agccagcggg agcaggaaag gaagcatgtt cccaggctgc ccacgcctct gggtcctggt      180

ggtcttgggc accagctggg taggctgggg gagccaaggg acagaagcgg cacagctaag      240

gcagttctac gtggctgctc agggcatcag ttggagctac cgacctgagc ccacaaactc      300

aagtttgaat ctttctgtaa cttcctttaa gaaaattgtc tacagagagt atgaaccata      360

ttttaagaaa gaaaaaccac aatctaccat ttcaggactt cttgggccta ctttatatgc      420

tgaagtcgga gacatcataa aagttcactt taaaaataag gcagataagc ccttgagcat      480

ccatcctcaa ggaattaggt acagtaaatt atcagaaggt gcttcttacc ttgaccacac      540

attccctgcg gagaagatgg acgacgctgt ggctccaggc cgagaataca cctatgaatg      600

gagtatcagt gaggacagtg gacccaccca tgatgaccct ccatgcctca cacacatcta      660

ttactcccat gaaaatctga tcgaggattt caactcgggg ctgattgggc ccctgcttat      720

ctgtaaaaaa gggaccctaa ctgagggtgg gacacagaag acgtttgaca agcaaatcgt      780

gctactattt gctgtgtttg atgaaagcaa gagctggagc cagtcatcat ccctaatgta      840

cacagtcaat ggatatgtga atgggacaat gccagatata acagtttgtg cccatgacca      900

catcagctgg catctgctgg gaatgagctc ggggccagaa ttattctcca ttcatttcaa      960

cggccaggtc ctggagcaga accatcataa ggtctcagcc atcacccttg tcagtgctac     1020

atccactacc gcaaatatga ctgtgggccc agagggaaag tggatcatat cttctctcac     1080

cccaaaacat ttgcaagctg ggatgcaggc ttacattgac attaaaaact gcccaaagaa     1140

aaccaggaat cttaagaaaa taactcgtga gcagaggcgg cacatgaaga ggtgggaata     1200

cttcattgct gcagaggaag tcatttggga ctatgcacct gtaataccag cgaatatgga     1260

caaaaaatac aggtctcagc atttggataa tttctcaaac caaattggaa aacattataa     1320

gaaagttatg tacacacagt acgaagatga gtccttcacc aaacatacag tgaatcccaa     1380

tatgaaagaa gatgggattt tgggtcctat tatcagagcc caggtcagag acacactcaa     1440

aatcgtgttc aaaaatatgg ccagccgccc ctatagcatt taccctcatg gagtgacctt     1500

ctcgccttat gaagatgaag tcaactcttc tttcacctca ggcaggaaca acaccatgat     1560

cagagcagtt caaccagggg aaacctatac ttataagtgg aacatcttag agtttgatga     1620

acccacagaa aatgatgccc agtgcttaac aagaccatac tacagtgacg tggacatcat     1680

gagagacatc gcctctgggc taataggact acttctaatc tgtaagagca gatccctgga     1740

caggcgagga atacagaggg cagcagacat cgaacagcag gctgtgtttg ctgtgtttga     1800

tgagaacaaa agctggtacc ttgaggacaa catcaacaag ttttgtgaaa atcctgatga     1860

ggtgaaacgt gatgacccca agttttatga atcaaacatc atgagcacta tcaatggcta     1920

tgtgcctgag agcataacta ctcttggatt ctgctttgat gacactgtcc agtggcactt     1980

ctgtagtgtg gggacccaga atgaaatttt gaccatccac ttcactgggc actcattcat     2040

ctatggaaag aggcatgagg acaccttgac cctcttcccc atgcgtggag aatctgtgac     2100

ggtcacaatg gataatgttg gaacttggat gttaacttcc atgaattcta gtccaagaag     2160

caaaaagctg aggctgaaat tcagggatgt taaatgtatc ccagatgatg atgaagactc     2220

atatgagatt tttgaacctc cagaatctac agtcatggct acacggaaaa tgcatgatcg     2280

tttagaacct gaagatgaag agagtgatgc tgactatgat taccagaaca gactggctgc     2340

agcattagga atcaggtcat tccgaaactc atcattgaat caggaagaag aagagttcaa     2400

tcttactgcc ctagctctgg agaatggcac tgaattcgtt tcttcaaaca cagatataat     2460

tgttggttca aattattctt ccccaagtaa tattagtaag ttcactgtca ataaccttgc     2520

agaacctcag aaagcccctt ctcaccaaca agccaccaca gctggttccc cactgagaca     2580

cctcattggc aagaactcag ttctcaattc ttccacagca gagcattcca gcccatattc     2640

tgaagaccct atagaggatc ctctacagcc agatgtcaca gggatacgtc tactttcact     2700

tggtgctgga gaattcaaaa gtcaagaaca tgctaagcat aagggaccca aggtagaaag     2760

agatcaagca gcaaagcaca ggttctcctg gatgaaatta ctagcacata aagttgggag     2820

acacctaagc caagacactg gttctccttc cggaatgagg ccctgggagg accttcctag     2880

ccaagacact ggttctcctt ccagaatgag gccctggaag gaccctccta gtgatctgtt     2940

actcttaaaa caaagtaact catctaagat tttggttggg agatggcatt tggcttctga     3000

gaaaggtagc tatgaaataa tccaagatac tgatgaagac acagctgtta acaattggct     3060

gatcagcccc cagaatgcct cacgtgcttg gggagaaagc acccctcttg ccaacaagcc     3120

tggaaagcag agtggccacc caaagtttcc tagagttaga cataaatctc tacaagtaag     3180

acaggatgga ggaaagagta gactgaagaa aagccagttt ctcattaaga cacgaaaaaa     3240

gaaaaaagag aagcacacac accatgctcc tttatctccg aggacctttc accctctaag     3300

aagtgaagcc tacaacacat tttcagaaag aagacttaag cattcgttgg tgcttcataa     3360

atccaatgaa acatctcttc ccacagacct caatcagaca ttgccctcta tggattttgg     3420

ctggatagcc tcacttcctg accataatca gaattcctca aatgacactg gtcaggcaag     3480

ctgtcctcca ggtctttatc agacagtgcc cccagaggaa cactatcaaa cattccccat     3540

tcaagaccct gatcaaatgc actctacttc agaccccagt cacagatcct cttctccaga     3600

gctcagtgaa atgcttgagt atgaccgaag tcacaagtcc ttccccacag atataagtca     3660

aatgtcccct tcctcagaac atgaagtctg gcagacagtc atctctccag acctcagcca     3720

ggtgaccctc tctccagaac tcagccagac aaacctctct ccagacctca gccacacgac     3780

tctctctcca gaactcattc agagaaacct ttccccagcc ctcggtcaga tgcccatttc     3840

tccagacctc agccatacaa ccctttctcc agacctcagc catacaaccc tttctttaga     3900

cctcagccag acaaacctct ctccagaact cagtcagaca aacctttctc cagccctcgg     3960

tcagatgccc ctttctccag acctcagcca tacaaccctt tctctagact tcagccagac     4020

aaacctctct ccagaactca gccatatgac tctctctcca gaactcagtc agacaaacct     4080

ttccccagcc ctcggtcaga tgcccatttc tccagacctc agccatacaa ccctttctct     4140

agacttcagc cagacaaacc tctctccaga actcagtcaa acaaaccttt ccccagccct     4200

cggtcagatg cccctttctc cagaccccag ccatacaacc ctttctctag acctcagcca     4260

gacaaacctc tctccagaac tcagtcagac aaacctttcc ccagacctca gtgagatgcc     4320

cctctttgca gatctcagtc aaattcccct taccccagac ctcgaccaga tgacactttc     4380

tccagacctt ggtgagacag atctttcccc aaactttggt cagatgtccc tttccccaga     4440

cctcagccag gtgactctct ctccagacat cagtgacacc acccttctcc cggatctcag     4500

ccagatatca cctcctccag accttgatca gatattctac ccttctgaat ctagtcagtc     4560

attgcttctt caagaattta atgagtcttt tccttatcca gaccttggtc agatgccatc     4620

tccttcatct cctactctca atgatacttt tctatcaaag gaatttaatc cactggttat     4680

agtgggcctc agtaaagatg gtacagatta cattgagatc attccaaagg aagaggtcca     4740

gagcagtgaa gatgactatg ctgaaattga ttatgtgccc tatgatgacc cctacaaaac     4800

tgatgttagg acaaacatca actcctccag agatcctgac aacattgcag catggtacct     4860

ccgcagcaac aatggaaaca gaagaaatta ttacattgct gctgaagaaa tatcctggga     4920

ttattcagaa tttgtacaaa gggaaacaga tattgaagac tctgatgata ttccagaaga     4980

taccacatat aagaaagtag tttttcgaaa gtacctcgac agcactttta ccaaacgtga     5040

tcctcgaggg gagtatgaag agcatctcgg aattcttggt cctattatca gagctgaagt     5100

ggatgatgtt atccaagttc gttttaaaaa tttagcatcc agaccgtatt ctctacatgc     5160

ccatggactt tcctatgaaa aatcatcaga gggaaagact tatgaagatg actctcctga     5220

atggtttaag gaagataatg ctgttcagcc aaatagcagt tatacctacg tatggcatgc     5280

cactgagcga tcagggccag aaagtcctgg ctctgcctgt cgggcttggg cctactactc     5340

agctgtgaac ccagaaaaag atattcactc aggcttgata ggtcccctcc taatctgcca     5400

aaaaggaata ctacataagg acagcaacat gcctatggac atgagagaat ttgtcttact     5460

atttatgacc tttgatgaaa agaagagctg gtactatgaa aagaagtccc gaagttcttg     5520

gagactcaca tcctcagaaa tgaaaaaatc ccatgagttt cacgccatta atgggatgat     5580

ctacagcttg cctggcctga aaatgtatga gcaagagtgg gtgaggttac acctgctgaa     5640

cataggcggc tcccaagaca ttcacgtggt tcactttcac ggccagacct tgctggaaaa     5700

tggcaataaa cagcaccagt taggggtctg gccccttctg cctggttcat ttaaaactct     5760

tgaaatgaag gcatcaaaac ctggctggtg gctcctaaac acagaggttg gagaaaacca     5820

gagagcaggg atgcaaacgc catttcttat catggacaga gactgtagga tgccaatggg     5880

actaagcact ggtatcatat ctgattcaca gatcaaggct tcagagtttc tgggttactg     5940

ggagcccaga ttagcaagat taaacaatgg tggatcttat aatgcttgga gtgtagaaaa     6000

acttgcagca gaatttgcct ctaaaccttg gatccaggtg gacatgcaaa aggaagtcat     6060

aatcacaggg atccagaccc aaggtgccaa acactacctg aagtcctgct ataccacaga     6120

gttctatgta gcttacagtt ccaaccagat caactggcag atcttcaaag ggaacagcac     6180

aaggaatgtg atgtatttta atggcaattc agatgcctct acaataaaag agaatcagtt     6240

tgacccacct attgtggcta gatatattag gatctctcca actcgagcct ataacagacc     6300

tacccttcga ttggaactgc aaggttgtga ggtaaatgga tgttccacac ccctgggtat     6360

ggaaaatgga aagatagaaa acaagcaaat cacagcttct tcgtttaaga aatcttggtg     6420

gggagattac tgggaaccct tccgtgcccg tctgaatgcc cagggacgtg tgaatgcctg     6480

gcaagccaag gcaaacaaca ataagcagtg gctagaaatt gatctactca agatcaagaa     6540

gataacggca attataacac agggctgcaa gtctctgtcc tctgaaatgt atgtaaagag     6600

ctataccatc cactacagtg agcagggagt ggaatggaaa ccatacaggc tgaaatcctc     6660

catggtggac aagatttttg aaggaaatac taataccaaa ggacatgtga agaacttttt     6720

caacccccca atcatttcca ggtttatccg tgtcattcct aaaacatgga atcaaagtat     6780

tgcacttcgc ctggaactct ttggctgtga tatttactag aattgaacat tcaaaaaccc     6840

ctggaagaga ctctttaaga cctcaaacca tttagaatgg gcaatgtatt ttacgctgtg     6900

ttaaatgtta acagttttcc actatttctc tttcttttct attagtgaat aaaattttat     6960

acaagaagct tttataatgt aactccttgc taccagtaag taagataatg gctattactt     7020

ctgcattaat ttgaatacag gtaggaaaat atcaagaacc aacaagaaaa gggcttatct     7080

ttcttaatga ttgaaaatgc tatgaagtaa tatttatgta gttaaaatgc ttcattataa     7140

ctcttttaaa tcctttacac actagtaaaa cagatattac tttaaataat aattgataga     7200

cctggataac tttcacaaac acatgatttt ttaatggttt ttcttgagtg aagagaaaaa     7260

caatattatc aaatgaaata agtacttaaa atatcctgtc tttcccatat aacaatgatt     7320

tttctgactt tccatgagta aaaaaacagc caagcatctt tccagtagcc ccattgaaat     7380

tgtgaatccg tcctggtctc cctaaggact gcacacattg atattcaagg ttggtggtca     7440

ttagatatgg aacagaactg aaataaccat ggtagaactg aatgtgtaat gttggcttta     7500

ttctagctgg tactacatgg cacacagttt caaaacataa tttcacctac tggaaagctc     7560

agacctgtaa aacagagcat gggaactgct ggtctaaatg cagttgttcc tgctcaaaga     7620

gacctctggc caaactggca agcagttaaa gttttctttc agggccttcc tctctatggc     7680

ctcaacttcc tcctctctct tcttccagca acttcccctt tcatcattcc tttccctggg     7740

gacttggcat tcagtgatcc tgtagatatt gcacaactgg ggaaccttta gacatcctta     7800

aaatcacatg agatagacag tcatttgggg tgtctgaaat aaaccacccc aaaacttagt     7860

gttaaaagag caaccaaaaa aaatttatgt gagattatgg atttgttact tagcttgatt     7920

taatcatcct gtaacgtgta catatatcaa aatgttatgt ataccataaa tatataaaat     7980

tttatcaacg aaattcataa caatctctca gaccacagag aaatcaaatt agaactgagg     8040

actaagaaac tcactcgaaa ccacacaact acatggaaac tgaacaacct gctcctgaat     8100

gactactggg taaataatga aattaaggca gaaataaata agttccttaa aaccaatgag     8160

aacaaagaga caacatacca gaatctctag gagacagggc tttgcttttg ctgcattcta     8220

ttcgttgtga acacaaatta caggccagtc tcgattcagt gtagaaggga actgcataag     8280

gaccacatac caggaggcat aattcactgg gagcatcttt agaaactacc agagttacct     8340

gttgcccata ccagtggggt aagccctatg aatgtatatg agagtttcaa acatccacaa     8400

aacattggct ttctaatatt cgtattccca ctattccttt cttttcatga ttcatgtcat     8460

tgtcccatca acatttctaa gatttccatt ccgttaagag caaaagagaa tgttggaagg     8520

tgggggaaaa catttctttg ttttctacag ggccagcttc ttggatgtgt gtgatctgtt     8580

cagttgcaaa gggtcacatg ctcagaagga ccgcatgcta aatttaatgc tttgcagtta     8640

ccctcttgaa atcctttatt ttttaagaag gaattcgaca tttccatttt tcaatgagcc     8700

ccacaaatta cgcagctagt cctgggcttc tctactctga aattgggcag gatctctctt     8760

gatctagaat ttactaaggc ataatagggg caagaaaatc ttatgaaata atggggggta     8820

gggaagagat gggaatggag catgagatcc agcttcgtta ttctctactt gagaaaaata     8880

aggccccaaa gattaaacaa cttgcccaag gatattgctt gttagtgtca gaactgaaac     8940

cagaaaccaa atgatcatat ccctagactt ttagtctgct ttctcttcca taaaatgaaa     9000

cttataatgt ttctaatcca ttgctcagac aggtagacat gaatattaat tgataatgac     9060

tattaattga tctggaaaat acttgtttgg ggatcaataa tatgtttggg ctattatcta     9120

atgctgtgta gaaatattaa aacccctgtt attttgaaat aaaaaagata cccactttt      9179


<210> 39
<211> 694
<212> PRT
<213> Homo sapiens

<400> 39
Met Glu Trp Gly Tyr Leu Leu Glu Val Thr Ser Leu Leu Ala Ala Leu 
1               5                   10                  15      


Ala Leu Leu Gln Arg Ser Ser Gly Ala Ala Ala Ala Ser Ala Lys Glu 
            20                  25                  30          


Leu Ala Cys Gln Glu Ile Thr Val Pro Leu Cys Lys Gly Ile Gly Tyr 
        35                  40                  45              


Asn Tyr Thr Tyr Met Pro Asn Gln Phe Asn His Asp Thr Gln Asp Glu 
    50                  55                  60                  


Ala Gly Leu Glu Val His Gln Phe Trp Pro Leu Val Glu Ile Gln Cys 
65                  70                  75                  80  


Ser Pro Asp Leu Lys Phe Phe Leu Cys Ser Met Tyr Thr Pro Ile Cys 
                85                  90                  95      


Leu Glu Asp Tyr Lys Lys Pro Leu Pro Pro Cys Arg Ser Val Cys Glu 
            100                 105                 110         


Arg Ala Lys Ala Gly Cys Ala Pro Leu Met Arg Gln Tyr Gly Phe Ala 
        115                 120                 125             


Trp Pro Asp Arg Met Arg Cys Asp Arg Leu Pro Glu Gln Gly Asn Pro 
    130                 135                 140                 


Asp Thr Leu Cys Met Asp Tyr Asn Arg Thr Asp Leu Thr Thr Ala Ala 
145                 150                 155                 160 


Pro Ser Pro Pro Arg Arg Leu Pro Pro Pro Pro Pro Gly Glu Gln Pro 
                165                 170                 175     


Pro Ser Gly Ser Gly His Gly Arg Pro Pro Gly Ala Arg Pro Pro His 
            180                 185                 190         


Arg Gly Gly Gly Arg Gly Gly Gly Gly Gly Asp Ala Ala Ala Pro Pro 
        195                 200                 205             


Ala Arg Gly Gly Gly Gly Gly Gly Lys Ala Arg Pro Pro Gly Gly Gly 
    210                 215                 220                 


Ala Ala Pro Cys Glu Pro Gly Cys Gln Cys Arg Ala Pro Met Val Ser 
225                 230                 235                 240 


Val Ser Ser Glu Arg His Pro Leu Tyr Asn Arg Val Lys Thr Gly Gln 
                245                 250                 255     


Ile Ala Asn Cys Ala Leu Pro Cys His Asn Pro Phe Phe Ser Gln Asp 
            260                 265                 270         


Glu Arg Ala Phe Thr Val Phe Trp Ile Gly Leu Trp Ser Val Leu Cys 
        275                 280                 285             


Phe Val Ser Thr Phe Ala Thr Val Ser Thr Phe Leu Ile Asp Met Glu 
    290                 295                 300                 


Arg Phe Lys Tyr Pro Glu Arg Pro Ile Ile Phe Leu Ser Ala Cys Tyr 
305                 310                 315                 320 


Leu Phe Val Ser Val Gly Tyr Leu Val Arg Leu Val Ala Gly His Glu 
                325                 330                 335     


Lys Val Ala Cys Ser Gly Gly Ala Pro Gly Ala Gly Gly Ala Gly Gly 
            340                 345                 350         


Ala Gly Gly Ala Ala Ala Gly Ala Gly Ala Ala Gly Ala Gly Ala Gly 
        355                 360                 365             


Gly Pro Gly Gly Arg Gly Glu Tyr Glu Glu Leu Gly Ala Val Glu Gln 
    370                 375                 380                 


His Val Arg Tyr Glu Thr Thr Gly Pro Ala Leu Cys Thr Val Val Phe 
385                 390                 395                 400 


Leu Leu Val Tyr Phe Phe Gly Met Ala Ser Ser Ile Trp Trp Val Ile 
                405                 410                 415     


Leu Ser Leu Thr Trp Phe Leu Ala Ala Gly Met Lys Trp Gly Asn Glu 
            420                 425                 430         


Ala Ile Ala Gly Tyr Ser Gln Tyr Phe His Leu Ala Ala Trp Leu Val 
        435                 440                 445             


Pro Ser Val Lys Ser Ile Ala Val Leu Ala Leu Ser Ser Val Asp Gly 
    450                 455                 460                 


Asp Pro Val Ala Gly Ile Cys Tyr Val Gly Asn Gln Ser Leu Asp Asn 
465                 470                 475                 480 


Leu Arg Gly Phe Val Leu Ala Pro Leu Val Ile Tyr Leu Phe Ile Gly 
                485                 490                 495     


Thr Met Phe Leu Leu Ala Gly Phe Val Ser Leu Phe Arg Ile Arg Ser 
            500                 505                 510         


Val Ile Lys Gln Gln Asp Gly Pro Thr Lys Thr His Lys Leu Glu Lys 
        515                 520                 525             


Leu Met Ile Arg Leu Gly Leu Phe Thr Val Leu Tyr Thr Val Pro Ala 
    530                 535                 540                 


Ala Val Val Val Ala Cys Leu Phe Tyr Glu Gln His Asn Arg Pro Arg 
545                 550                 555                 560 


Trp Glu Ala Thr His Asn Cys Pro Cys Leu Arg Asp Leu Gln Pro Asp 
                565                 570                 575     


Gln Ala Arg Arg Pro Asp Tyr Ala Val Phe Met Leu Lys Tyr Phe Met 
            580                 585                 590         


Cys Leu Val Val Gly Ile Thr Ser Gly Val Trp Val Trp Ser Gly Lys 
        595                 600                 605             


Thr Leu Glu Ser Trp Arg Ser Leu Cys Thr Arg Cys Cys Trp Ala Ser 
    610                 615                 620                 


Lys Gly Ala Ala Val Gly Gly Gly Ala Gly Ala Thr Ala Ala Gly Gly 
625                 630                 635                 640 


Gly Gly Gly Pro Gly Gly Gly Gly Gly Gly Gly Pro Gly Gly Gly Gly 
                645                 650                 655     


Gly Pro Gly Gly Gly Gly Gly Ser Leu Tyr Ser Asp Val Ser Thr Gly 
            660                 665                 670         


Leu Thr Trp Arg Ser Gly Thr Ala Ser Ser Val Ser Tyr Pro Lys Gln 
        675                 680                 685             


Met Pro Leu Ser Gln Val 
    690                 


<210> 40
<211> 3195
<212> DNA
<213> Homo sapiens

<400> 40
acagcatgga gtggggttac ctgttggaag tgacctcgct gctggccgcc ttggcgctgc       60

tgcagcgctc tagcggcgct gcggccgcct cggccaagga gctggcatgc caagagatca      120

ccgtgccgct gtgtaagggc atcggctaca actacaccta catgcccaat cagttcaacc      180

acgacacgca agacgaggcg ggcctggagg tgcaccagtt ctggccgctg gtggagatcc      240

agtgctcgcc cgatctcaag ttcttcctgt gcagcatgta cacgcccatc tgcctagagg      300

actacaagaa gccgctgccg ccctgccgct cggtgtgcga gcgcgccaag gccggctgcg      360

cgccgctcat gcgccagtac ggcttcgcct ggcccgaccg catgcgctgc gaccggctgc      420

ccgagcaagg caaccctgac acgctgtgca tggactacaa ccgcaccgac ctaaccaccg      480

ccgcgcccag cccgccgcgc cgcctgccgc cgccgccgcc cggcgagcag ccgccttcgg      540

gcagcggcca cggccgcccg ccgggggcca ggcccccgca ccgcggaggc ggcaggggcg      600

gtggcggcgg ggacgcggcg gcgcccccag ctcgcggcgg cggcggtggc gggaaggcgc      660

ggccccctgg cggcggcgcg gctccctgcg agcccgggtg ccagtgccgc gcgcctatgg      720

tgagcgtgtc cagcgagcgc cacccgctct acaaccgcgt caagacaggc cagatcgcta      780

actgcgcgct gccctgccac aacccctttt tcagccagga cgagcgcgcc ttcaccgtct      840

tctggatcgg cctgtggtcg gtgctctgct tcgtgtccac cttcgccacc gtctccacct      900

tccttatcga catggagcgc ttcaagtacc cggagcggcc cattatcttc ctctcggcct      960

gctacctctt cgtgtcggtg ggctacctag tgcgcctggt ggcgggccac gagaaggtgg     1020

cgtgcagcgg tggcgcgccg ggcgcggggg gcgctggggg cgcgggcggc gcggcggcgg     1080

gcgcgggcgc ggcgggcgcg ggcgcgggcg gcccgggcgg gcgcggcgag tacgaggagc     1140

tgggcgcggt ggagcagcac gtgcgctacg agaccaccgg ccccgcgctg tgcaccgtgg     1200

tcttcttgct ggtctacttc ttcggcatgg ccagctccat ctggtgggtg atcttgtcgc     1260

tcacatggtt cctggcggcc ggtatgaagt ggggcaacga agccatcgcc ggctactcgc     1320

agtacttcca cctggccgcg tggcttgtgc ccagcgtcaa gtccatcgcg gtgctggcgc     1380

tcagctcggt ggacggcgac ccggtggcgg gcatctgcta cgtgggcaac cagagcctgg     1440

acaacctgcg cggcttcgtg ctggcgccgc tggtcatcta cctcttcatc ggcaccatgt     1500

tcctgctggc cggcttcgtg tccctgttcc gcatccgctc ggtcatcaag caacaggacg     1560

gccccaccaa gacgcacaag ctggagaagc tgatgatccg cctgggcctg ttcaccgtgc     1620

tctacaccgt gcccgccgcg gtggtggtcg cctgcctctt ctacgagcag cacaaccgcc     1680

cgcgctggga ggccacgcac aactgcccgt gcctgcggga cctgcagccc gaccaggcac     1740

gcaggcccga ctacgccgtc ttcatgctca agtacttcat gtgcctagtg gtgggcatca     1800

cctcgggcgt gtgggtctgg tccggcaaga cgctggagtc ctggcgctcc ctgtgcaccc     1860

gctgctgctg ggccagcaag ggcgccgcgg tgggcggggg cgcgggcgcc acggccgcgg     1920

ggggtggcgg cgggccgggg ggcggcggcg gcgggggacc cggcggcggc ggggggccgg     1980

gcggcggcgg gggctccctc tacagcgacg tcagcactgg cctgacgtgg cggtcgggca     2040

cggcgagctc cgtgtcttat ccaaagcaga tgccattgtc ccaggtctga gcggagggga     2100

gggggcgccc aggaggggtg gggagggggg cgaggagacc caagtgcagc gaagggacac     2160

ttgatgggct gaggttccca ccccttcaca gtgttgattg ctattagcat gataatgaac     2220

tcttaatggt atccattagc tgggacttaa atgactcact tagaacaaag tacctggcat     2280

tgaagcctcc cagacccagc cccttttcct ccattgatgt gcggggagct cctcccgcca     2340

cgcgttaatt tctgttggct gaggagggtg gactctgcgg cgtttccaga acccgagatt     2400

tggagccctc cctggctgca cttggctggg tttgcagtca gatacacaga tttcacctgg     2460

gagaacctct ttttctccct cgactcttcc tacgtaaact cccacccctg acttaccctg     2520

gaggaggggt gaccgccacc tgatgggatt gcacggtttg ggtattctta atgaccaggc     2580

aaatgcctta agtaaacaaa caagaaatgt cttaattata caccccacgt aaatacgggt     2640

ttcttacatt agaggatgta tttatataat tatttgttaa attgtaaaaa aaaaaagtgt     2700

aaaatatgta tatatccaaa gatatagtgt gtacattttt ttgtaaaaag tttagaggct     2760

tacccctgta agaacagata taagtattct attttgtcaa taaaatgact tttgataaat     2820

gatttaacca ttgccctctc ccccgcctct tctgagctgt cacctttaaa gtgcttgcta     2880

aggacgcatg gggaaaatgg acattttctg gcttgtcatt ctgtacactg accttaggca     2940

tggagaaaat tacttgttaa actctagttc ttaagttgtt agccaagtaa atatcattgt     3000

tgaactgaaa tcaaaattga gtttttgcac cttccccaaa gacggtgttt ttcatgggag     3060

ctcttttctg atccatggat aacaactctc actttagtgg atgtaaatgg aacttctgca     3120

aggcagtaat tccccttagg ccttgttatt tatcctgcat ggtatcacta aaggtttcaa     3180

aaccctgaaa aaaaa                                                      3195


<210> 41
<211> 220
<212> PRT
<213> Homo sapiens

<400> 41
Met Ser Met Gly Leu Glu Ile Thr Gly Thr Ala Leu Ala Val Leu Gly 
1               5                   10                  15      


Trp Leu Gly Thr Ile Val Cys Cys Ala Leu Pro Met Trp Arg Val Ser 
            20                  25                  30          


Ala Phe Ile Gly Ser Asn Ile Ile Thr Ser Gln Asn Ile Trp Glu Gly 
        35                  40                  45              


Leu Trp Met Asn Cys Val Val Gln Ser Thr Gly Gln Met Gln Cys Lys 
    50                  55                  60                  


Val Tyr Asp Ser Leu Leu Ala Leu Pro Gln Asp Leu Gln Ala Ala Arg 
65                  70                  75                  80  


Ala Leu Ile Val Val Ala Ile Leu Leu Ala Ala Phe Gly Leu Leu Val 
                85                  90                  95      


Ala Leu Val Gly Ala Gln Cys Thr Asn Cys Val Gln Asp Asp Thr Ala 
            100                 105                 110         


Lys Ala Lys Ile Thr Ile Val Ala Gly Val Leu Phe Leu Leu Ala Ala 
        115                 120                 125             


Leu Leu Thr Leu Val Pro Val Ser Trp Ser Ala Asn Thr Ile Ile Arg 
    130                 135                 140                 


Asp Phe Tyr Asn Pro Val Val Pro Glu Ala Gln Lys Arg Glu Met Gly 
145                 150                 155                 160 


Ala Gly Leu Tyr Val Gly Trp Ala Ala Ala Ala Leu Gln Leu Leu Gly 
                165                 170                 175     


Gly Ala Leu Leu Cys Cys Ser Cys Pro Pro Arg Glu Lys Lys Tyr Thr 
            180                 185                 190         


Ala Thr Lys Val Val Tyr Ser Ala Pro Arg Ser Thr Gly Pro Gly Ala 
        195                 200                 205             


Ser Leu Gly Thr Gly Tyr Asp Arg Lys Asp Tyr Val 
    210                 215                 220 


<210> 42
<211> 1318
<212> DNA
<213> Homo sapiens

<400> 42
agcccagtcg ccgccgcccg cccacaaagc cacaggcagg tgcaggcgca gccgcggcga       60

gagcgtatgg agccgagccg ttagcgcgcg ccgtcggtga gtcagtccgt ccgtccgtcc      120

gtccgtcggg gcgccgcagc tcccgccagg cccagcggcc ccggcccctc gtctccccgc      180

acccggagcc acccggtgga gcgggccttg ccgcggcagc catgtccatg ggcctggaga      240

tcacgggcac cgcgctggcc gtgctgggct ggctgggcac catcgtgtgc tgcgcgttgc      300

ccatgtggcg cgtgtcggcc ttcatcggca gcaacatcat cacgtcgcag aacatctggg      360

agggcctgtg gatgaactgc gtggtgcaga gcaccggcca gatgcagtgc aaggtgtacg      420

actcgctgct ggcactgcca caggaccttc aggcggcccg cgccctcatc gtggtggcca      480

tcctgctggc cgccttcggg ctgctagtgg cgctggtggg cgcccagtgc accaactgcg      540

tgcaggacga cacggccaag gccaagatca ccatcgtggc aggcgtgctg ttccttctcg      600

ccgccctgct caccctcgtg ccggtgtcct ggtcggccaa caccattatc cgggacttct      660

acaaccccgt ggtgcccgag gcgcagaagc gcgagatggg cgcgggcctg tacgtgggct      720

gggcggccgc ggcgctgcag ctgctggggg gcgcgctgct ctgctgctcg tgtcccccac      780

gcgagaagaa gtacacggcc accaaggtcg tctactccgc gccgcgctcc accggcccgg      840

gagccagcct gggcacaggc tacgaccgca aggactacgt ctaagggaca gacgcaggga      900

gaccccacca ccaccaccac caccaacacc accaccacca ccgcgagctg gagcgcgcac      960

caggccatcc agcgtgcagc cttgcctcgg aggccagccc acccccagaa gccaggaagc     1020

ccccgcgctg gactggggca gcttccccag cagccacggc tttgcgggcc gggcagtcga     1080

cttcggggcc cagggaccaa cctgcatgga ctgtgaaacc tcacccttct ggagcacggg     1140

gcctgggtga ccgccaatac ttgaccaccc cgtcgagccc catcgggccg ctgcccccat     1200

gctcgcgctg ggcagggacc ggcagccctg gaaggggcac ttgatatttt tcaataaaag     1260

cctttcgttt tgcaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa       1318


<210> 43
<211> 264
<212> PRT
<213> Homo sapiens

<400> 43
Met Ile Met Ser Ser Tyr Leu Met Asp Ser Asn Tyr Ile Asp Pro Lys 
1               5                   10                  15      


Phe Pro Pro Cys Glu Glu Tyr Ser Gln Asn Ser Tyr Ile Pro Glu His 
            20                  25                  30          


Ser Pro Glu Tyr Tyr Gly Arg Thr Arg Glu Ser Gly Phe Gln His His 
        35                  40                  45              


His Gln Glu Leu Tyr Pro Pro Pro Pro Pro Arg Pro Ser Tyr Pro Glu 
    50                  55                  60                  


Arg Gln Tyr Ser Cys Thr Ser Leu Gln Gly Pro Gly Asn Ser Arg Gly 
65                  70                  75                  80  


His Gly Pro Ala Gln Ala Gly His His His Pro Glu Lys Ser Gln Ser 
                85                  90                  95      


Leu Cys Glu Pro Ala Pro Leu Ser Gly Ala Ser Ala Ser Pro Ser Pro 
            100                 105                 110         


Ala Pro Pro Ala Cys Ser Gln Pro Ala Pro Asp His Pro Ser Ser Ala 
        115                 120                 125             


Ala Ser Lys Gln Pro Ile Val Tyr Pro Trp Met Lys Lys Ile His Val 
    130                 135                 140                 


Ser Thr Val Asn Pro Asn Tyr Asn Gly Gly Glu Pro Lys Arg Ser Arg 
145                 150                 155                 160 


Thr Ala Tyr Thr Arg Gln Gln Val Leu Glu Leu Glu Lys Glu Phe His 
                165                 170                 175     


Tyr Asn Arg Tyr Leu Thr Arg Arg Arg Arg Ile Glu Ile Ala His Ser 
            180                 185                 190         


Leu Cys Leu Ser Glu Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg 
        195                 200                 205             


Met Lys Trp Lys Lys Asp His Arg Leu Pro Asn Thr Lys Val Arg Ser 
    210                 215                 220                 


Ala Pro Pro Ala Gly Ala Ala Pro Ser Thr Leu Ser Ala Ala Thr Pro 
225                 230                 235                 240 


Gly Thr Ser Glu Asp His Ser Gln Ser Ala Thr Pro Pro Glu Gln Gln 
                245                 250                 255     


Arg Ala Glu Asp Ile Thr Arg Leu 
            260                 


<210> 44
<211> 2328
<212> DNA
<213> Homo sapiens

<400> 44
aactttttat tgtggtttgt ccgttccgag cgctccgcag aacagtcctc cctgtaagag       60

cctaaccatt gccagggaaa cctgccctgg gcgctccctt cattagcagt atttttttta      120

aattaatctg attaataatt atttttcccc catttaattt tttttcctcc caggtggagt      180

tgccgaagct gggggcagct ggggagggtg gggatgggag gggagagaca gaagttgagg      240

gcatctctct cttccttccc gaccctctgg cccccaaggg gcaggaggaa tgcaggagca      300

ggagttgagc ttgggagctg cagatgcctc cgcccctcct ctctcccagg ctcttcctcc      360

tgcccccttc ttgcaactct ccttaatttt gtttggcttt tggatgatta taattatttt      420

tatttttgaa tttatataaa gtatatgtgt gtgtgtgtgg agctgagaca ggctcggcag      480

cggcacagaa tgagggaaga cgagaaagag agtgggagag agagaggcag agagggagag      540

agggagagtg acagcagcgc tcgcgggggc tcaaccccca gacctccaga aatgacgtca      600

gaatcatttg catcccgctg cctctacctg cctggtccag ctgggaccct gcctcgccgg      660

ccgcatggcc agagggttgg aaattaatga tcatgagctc gtatttgatg gactctaact      720

acatcgatcc gaaatttcct ccatgcgaag aatattcgca aaatagctac atccctgaac      780

acagtccgga atattacggc cggaccaggg aatcgggatt ccagcatcac caccaggagc      840

tgtacccacc accgcctccg cgccctagct accctgagcg ccagtatagc tgcaccagtc      900

tccaggggcc cggcaattcg cgaggccacg ggccggccca ggcgggccac caccaccccg      960

agaaatcaca gtcgctctgc gagccggcgc ctctctcagg cgcctccgcc tccccgtccc     1020

cagccccgcc agcctgcagc cagccagccc ccgaccatcc ctccagcgcc gccagcaagc     1080

aacccatagt ctacccatgg atgaaaaaaa ttcacgttag cacggtgaac cccaattata     1140

acggagggga acccaagcgc tcgaggacag cctatacccg gcagcaagtc ctggaattag     1200

agaaagagtt tcattacaac cgctacctga cccgaaggag aaggatcgag atcgcccact     1260

cgctgtgcct ctctgagagg cagatcaaaa tctggttcca aaaccgtcgc atgaaatgga     1320

agaaggacca ccgactcccc aacaccaaag tcaggtcagc acccccggcc ggcgctgcgc     1380

ccagcaccct ttcggcagct accccgggta cttctgaaga ccactcccag agcgccacgc     1440

cgccggagca gcaacgggca gaggacatta ccaggttata aaacataact cacacccctg     1500

cccccacccc atgcccccac cctcccctca cacacaaatt gactcttatt tatagaattt     1560

aatatatata tatatatata tatatatagg ttcttttctc tcttcctctc accttgtccc     1620

ttgtcagttc caaacagaca aaacagataa acaaacaagc cccctgccct cctctccctc     1680

ccactgttaa ggaccctttt aagcatgtga tgttgtctta gcatggtacc tgctgggtgt     1740

ttttttttaa aaggccattt tggggggtta tttatttttt aagaaaaaaa gctgcaaaaa     1800

ttatatattg caaggtgtga tggtctggct tgggtgaatt tcaggggaaa tgaggaaaag     1860

aaaaaaggaa agaaatttta aagccaattc tcatccttct cctcctcctc cttccccccc     1920

tctttcctta ggccttttgc attgaaaatg caccagggga ggttagtgag ggggaagtca     1980

ttttaaggag aacaaagcta tgaagttctt ttgtattatt gttggggggg ggtgtgggag     2040

gagagggggc gaagacagca gacaaagcta aatgcatctg gagagcctct cagagctgtt     2100

cagtttgagg agccaaaaga aaatcaaaat gaactttcag ttcagagagg cagtctatag     2160

gtagaatctc tccccacccc tatcgtggtt attgtgtttt tggactgaat ttacttgatt     2220

attgtaaaac ttgcaataaa gaattttagt gtcgatgtga aatgccccgt gatcaataat     2280

aaaccagtgg atgtgaatta gttttaaaaa aaaaaaaaaa aaaaaaaa                  2328


<210> 45
<211> 264
<212> PRT
<213> Homo sapiens

<400> 45
Met Ile Met Ser Ser Tyr Leu Met Asp Ser Asn Tyr Ile Asp Pro Lys 
1               5                   10                  15      


Phe Pro Pro Cys Glu Glu Tyr Ser Gln Asn Ser Tyr Ile Pro Glu His 
            20                  25                  30          


Ser Pro Glu Tyr Tyr Gly Arg Thr Arg Glu Ser Gly Phe Gln His His 
        35                  40                  45              


His Gln Glu Leu Tyr Pro Pro Pro Pro Pro Arg Pro Ser Tyr Pro Glu 
    50                  55                  60                  


Arg Gln Tyr Ser Cys Thr Ser Leu Gln Gly Pro Gly Asn Ser Arg Gly 
65                  70                  75                  80  


His Gly Pro Ala Gln Ala Gly His His His Pro Glu Lys Ser Gln Ser 
                85                  90                  95      


Leu Cys Glu Pro Ala Pro Leu Ser Gly Ala Ser Ala Ser Pro Ser Pro 
            100                 105                 110         


Ala Pro Pro Ala Cys Ser Gln Pro Ala Pro Asp His Pro Ser Ser Ala 
        115                 120                 125             


Ala Ser Lys Gln Pro Ile Val Tyr Pro Trp Met Lys Lys Ile His Val 
    130                 135                 140                 


Ser Thr Val Asn Pro Asn Tyr Asn Gly Gly Glu Pro Lys Arg Ser Arg 
145                 150                 155                 160 


Thr Ala Tyr Thr Arg Gln Gln Val Leu Glu Leu Glu Lys Glu Phe His 
                165                 170                 175     


Tyr Asn Arg Tyr Leu Thr Arg Arg Arg Arg Ile Glu Ile Ala His Ser 
            180                 185                 190         


Leu Cys Leu Ser Glu Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg 
        195                 200                 205             


Met Lys Trp Lys Lys Asp His Arg Leu Pro Asn Thr Lys Val Arg Ser 
    210                 215                 220                 


Ala Pro Pro Ala Gly Ala Ala Pro Ser Thr Leu Ser Ala Ala Thr Pro 
225                 230                 235                 240 


Gly Thr Ser Glu Asp His Ser Gln Ser Ala Thr Pro Pro Glu Gln Gln 
                245                 250                 255     


Arg Ala Glu Asp Ile Thr Arg Leu 
            260                 


<210> 46
<211> 2459
<212> DNA
<213> Homo sapiens

<400> 46
acacacgtgt tacatggata cagctcctag ccagaagcaa gcaggctcta cccacacagg       60

cctccctctt agctagcggg ggctcaaccc ccagacctcc agaaatgacg tcagaatcat      120

ttgcatcccg ctgcctctac ctgcctggtc cagctgggac cctgcctcgc cggccgcatg      180

gccagagggt tgggtgagtg tgtatgggga agaggggctg gactctggta tccttggatg      240

gggggcactc caggctctcc agcctcctcg gctcagcctg ggcccctccc catccaacat      300

ccactccagt cctcattcaa cttcctcttc ctgcgaaaga ggggcgctgc cccgtgacct      360

acacagactg agacacgatc gccatgaatg gagacctctg gaaaagctca ggagccgagg      420

cccacggggc ccagcagagg cctgagggga gaccctgggc gggggctgaa tcactgcctc      480

ccgacagtcc cccaatgccc gggctttgga ggggagccgg gagcttccca tctccttttg      540

caggggaggg ttgtcagtct ggcgggatgt gcactggggg cactccaacc tctgctagct      600

aaccccacat caccacccac ccccgcctcc cagcaccacc accaccacac acacaaaaaa      660

attggataca ttttgaataa agcgattcgg ttccttatcc ggggactggg ttgctccgtg      720

tgattggccg gaggagtcac atggtgaaag taactttaca gggtcgctag ctagtaggag      780

ggctttatgg agcagaaaaa cgacaaagcg agaaaaatta ttttccactc cagaaattaa      840

tgatcatgag ctcgtatttg atggactcta actacatcga tccgaaattt cctccatgcg      900

aagaatattc gcaaaatagc tacatccctg aacacagtcc ggaatattac ggccggacca      960

gggaatcggg attccagcat caccaccagg agctgtaccc accaccgcct ccgcgcccta     1020

gctaccctga gcgccagtat agctgcacca gtctccaggg gcccggcaat tcgcgaggcc     1080

acgggccggc ccaggcgggc caccaccacc ccgagaaatc acagtcgctc tgcgagccgg     1140

cgcctctctc aggcgcctcc gcctccccgt ccccagcccc gccagcctgc agccagccag     1200

cccccgacca tccctccagc gccgccagca agcaacccat agtctaccca tggatgaaaa     1260

aaattcacgt tagcacggtg aaccccaatt ataacggagg ggaacccaag cgctcgagga     1320

cagcctatac ccggcagcaa gtcctggaat tagagaaaga gtttcattac aaccgctacc     1380

tgacccgaag gagaaggatc gagatcgccc actcgctgtg cctctctgag aggcagatca     1440

aaatctggtt ccaaaaccgt cgcatgaaat ggaagaagga ccaccgactc cccaacacca     1500

aagtcaggtc agcacccccg gccggcgctg cgcccagcac cctttcggca gctaccccgg     1560

gtacttctga agaccactcc cagagcgcca cgccgccgga gcagcaacgg gcagaggaca     1620

ttaccaggtt ataaaacata actcacaccc ctgcccccac cccatgcccc caccctcccc     1680

tcacacacaa attgactctt atttatagaa tttaatatat atatatatat atatatatat     1740

aggttctttt ctctcttcct ctcaccttgt cccttgtcag ttccaaacag acaaaacaga     1800

taaacaaaca agccccctgc cctcctctcc ctcccactgt taaggaccct tttaagcatg     1860

tgatgttgtc ttagcatggt acctgctggg tgtttttttt taaaaggcca ttttgggggg     1920

ttatttattt tttaagaaaa aaagctgcaa aaattatata ttgcaaggtg tgatggtctg     1980

gcttgggtga atttcagggg aaatgaggaa aagaaaaaag gaaagaaatt ttaaagccaa     2040

ttctcatcct tctcctcctc ctccttcccc ccctctttcc ttaggccttt tgcattgaaa     2100

atgcaccagg ggaggttagt gagggggaag tcattttaag gagaacaaag ctatgaagtt     2160

cttttgtatt attgttgggg gggggtgtgg gaggagaggg ggcgaagaca gcagacaaag     2220

ctaaatgcat ctggagagcc tctcagagct gttcagtttg aggagccaaa agaaaatcaa     2280

aatgaacttt cagttcagag aggcagtcta taggtagaat ctctccccac ccctatcgtg     2340

gttattgtgt ttttggactg aatttacttg attattgtaa aacttgcaat aaagaatttt     2400

agtgtcgatg tgaaatgccc cgtgatcaat aataaaccag tggatgtgaa ttagtttta      2459


<210> 47
<211> 2120
<212> PRT
<213> Homo sapiens

<400> 47
Met Arg Ser Phe Lys Arg Val Asn Phe Gly Thr Leu Leu Ser Ser Gln 
1               5                   10                  15      


Lys Glu Ala Glu Glu Leu Leu Pro Ala Leu Lys Glu Phe Leu Ser Asn 
            20                  25                  30          


Pro Pro Ala Gly Phe Pro Ser Ser Arg Ser Asp Ala Glu Arg Arg Gln 
        35                  40                  45              


Ala Cys Asp Ala Ile Leu Arg Ala Cys Asn Gln Gln Leu Thr Ala Lys 
    50                  55                  60                  


Leu Ala Cys Pro Arg His Leu Gly Ser Leu Leu Glu Leu Ala Glu Leu 
65                  70                  75                  80  


Ala Cys Asp Gly Tyr Leu Val Ser Thr Pro Gln Arg Pro Pro Leu Tyr 
                85                  90                  95      


Leu Glu Arg Ile Leu Phe Val Leu Leu Arg Asn Ala Ala Ala Gln Gly 
            100                 105                 110         


Ser Pro Glu Ala Thr Leu Arg Leu Ala Gln Pro Leu His Ala Cys Leu 
        115                 120                 125             


Val Gln Cys Ser Arg Glu Ala Ala Pro Gln Asp Tyr Glu Ala Val Ala 
    130                 135                 140                 


Arg Gly Ser Phe Ser Leu Leu Trp Lys Gly Ala Glu Ala Leu Leu Glu 
145                 150                 155                 160 


Arg Arg Ala Ala Phe Ala Ala Arg Leu Lys Ala Leu Ser Phe Leu Val 
                165                 170                 175     


Leu Leu Glu Asp Glu Ser Thr Pro Cys Glu Val Pro His Phe Ala Ser 
            180                 185                 190         


Pro Thr Ala Cys Arg Ala Val Ala Ala His Gln Leu Phe Asp Ala Ser 
        195                 200                 205             


Gly His Gly Leu Asn Glu Ala Asp Ala Asp Phe Leu Asp Asp Leu Leu 
    210                 215                 220                 


Ser Arg His Val Ile Arg Ala Leu Val Gly Glu Arg Gly Ser Ser Ser 
225                 230                 235                 240 


Gly Leu Leu Ser Pro Gln Arg Ala Leu Cys Leu Leu Glu Leu Thr Leu 
                245                 250                 255     


Glu His Cys Arg Arg Phe Cys Trp Ser Arg His His Asp Lys Ala Ile 
            260                 265                 270         


Ser Ala Val Glu Lys Ala His Ser Tyr Leu Arg Asn Thr Asn Leu Ala 
        275                 280                 285             


Pro Ser Leu Gln Leu Cys Gln Leu Gly Val Lys Leu Leu Gln Val Gly 
    290                 295                 300                 


Glu Glu Gly Pro Gln Ala Val Ala Lys Leu Leu Ile Lys Ala Ser Ala 
305                 310                 315                 320 


Val Leu Ser Lys Ser Met Glu Ala Pro Ser Pro Pro Leu Arg Ala Leu 
                325                 330                 335     


Tyr Glu Ser Cys Gln Phe Phe Leu Ser Gly Leu Glu Arg Gly Thr Lys 
            340                 345                 350         


Arg Arg Tyr Arg Leu Asp Ala Ile Leu Ser Leu Phe Ala Phe Leu Gly 
        355                 360                 365             


Gly Tyr Cys Ser Leu Leu Gln Gln Leu Arg Asp Asp Gly Val Tyr Gly 
    370                 375                 380                 


Gly Ser Ser Lys Gln Gln Gln Ser Phe Leu Gln Met Tyr Phe Gln Gly 
385                 390                 395                 400 


Leu His Leu Tyr Thr Val Val Val Tyr Asp Phe Ala Gln Gly Cys Gln 
                405                 410                 415     


Ile Val Asp Leu Ala Asp Leu Thr Gln Leu Val Asp Ser Cys Lys Ser 
            420                 425                 430         


Thr Val Val Trp Met Leu Glu Ala Leu Glu Gly Leu Ser Gly Gln Glu 
        435                 440                 445             


Leu Thr Asp His Met Gly Met Thr Ala Ser Tyr Thr Ser Asn Leu Ala 
    450                 455                 460                 


Tyr Ser Phe Tyr Ser His Lys Leu Tyr Ala Glu Ala Cys Ala Ile Ser 
465                 470                 475                 480 


Glu Pro Leu Cys Gln His Leu Gly Leu Val Lys Pro Gly Thr Tyr Pro 
                485                 490                 495     


Glu Val Pro Pro Glu Lys Leu His Arg Cys Phe Arg Leu Gln Val Glu 
            500                 505                 510         


Ser Leu Lys Lys Leu Gly Lys Gln Ala Gln Gly Cys Lys Met Val Ile 
        515                 520                 525             


Leu Trp Leu Ala Ala Leu Gln Pro Cys Ser Pro Glu His Met Ala Glu 
    530                 535                 540                 


Pro Val Thr Phe Trp Val Arg Val Lys Met Asp Ala Ala Arg Ala Gly 
545                 550                 555                 560 


Asp Lys Glu Leu Gln Leu Lys Thr Leu Arg Asp Ser Leu Ser Gly Trp 
                565                 570                 575     


Asp Pro Glu Thr Leu Ala Leu Leu Leu Arg Glu Glu Leu Gln Ala Tyr 
            580                 585                 590         


Lys Ala Val Arg Ala Asp Thr Gly Gln Glu Arg Phe Asn Ile Ile Cys 
        595                 600                 605             


Asp Leu Leu Glu Leu Ser Pro Glu Glu Thr Pro Ala Gly Ala Trp Ala 
    610                 615                 620                 


Arg Ala Thr His Leu Val Glu Leu Ala Gln Val Leu Cys Tyr His Asp 
625                 630                 635                 640 


Phe Thr Gln Gln Thr Asn Cys Ser Ala Leu Asp Ala Ile Arg Glu Ala 
                645                 650                 655     


Leu Gln Leu Leu Asp Ser Val Arg Pro Glu Ala Gln Ala Arg Asp Gln 
            660                 665                 670         


Leu Leu Asp Asp Lys Ala Gln Ala Leu Leu Trp Leu Tyr Ile Cys Thr 
        675                 680                 685             


Leu Glu Ala Lys Met Gln Glu Gly Ile Glu Arg Asp Arg Arg Ala Gln 
    690                 695                 700                 


Ala Pro Gly Asn Leu Glu Glu Phe Glu Val Asn Asp Leu Asn Tyr Glu 
705                 710                 715                 720 


Asp Lys Leu Gln Glu Asp Arg Phe Leu Tyr Ser Asn Ile Ala Phe Asn 
                725                 730                 735     


Leu Ala Ala Asp Ala Ala Gln Ser Lys Cys Leu Asp Gln Ala Leu Ala 
            740                 745                 750         


Leu Trp Lys Glu Leu Leu Thr Lys Gly Gln Ala Pro Ala Val Arg Cys 
        755                 760                 765             


Leu Gln Gln Thr Ala Ala Ser Leu Gln Ile Leu Ala Ala Leu Tyr Gln 
    770                 775                 780                 


Leu Val Ala Lys Pro Met Gln Ala Leu Glu Val Leu Leu Leu Leu Arg 
785                 790                 795                 800 


Ile Val Ser Glu Arg Leu Lys Asp His Ser Lys Ala Ala Gly Ser Ser 
                805                 810                 815     


Cys His Ile Thr Gln Leu Leu Leu Thr Leu Gly Cys Pro Ser Tyr Ala 
            820                 825                 830         


Gln Leu His Leu Glu Glu Ala Ala Ser Ser Leu Lys His Leu Asp Gln 
        835                 840                 845             


Thr Thr Asp Thr Tyr Leu Leu Leu Ser Leu Thr Cys Asp Leu Leu Arg 
    850                 855                 860                 


Ser Gln Leu Tyr Trp Thr His Gln Lys Val Thr Lys Gly Val Ser Leu 
865                 870                 875                 880 


Leu Leu Ser Val Leu Arg Asp Pro Ala Leu Gln Lys Ser Ser Lys Ala 
                885                 890                 895     


Trp Tyr Leu Leu Arg Val Gln Val Leu Gln Leu Val Ala Ala Tyr Leu 
            900                 905                 910         


Ser Leu Pro Ser Asn Asn Leu Ser His Ser Leu Trp Glu Gln Leu Cys 
        915                 920                 925             


Ala Gln Gly Trp Gln Thr Pro Glu Ile Ala Leu Ile Asp Ser His Lys 
    930                 935                 940                 


Leu Leu Arg Ser Ile Ile Leu Leu Leu Met Gly Ser Asp Ile Leu Ser 
945                 950                 955                 960 


Thr Gln Lys Ala Ala Val Glu Thr Ser Phe Leu Asp Tyr Gly Glu Asn 
                965                 970                 975     


Leu Val Gln Lys Trp Gln Val Leu Ser Glu Val Leu Ser Cys Ser Glu 
            980                 985                 990         


Lys Leu Val Cys His Leu Gly Arg  Leu Gly Ser Val Ser  Glu Ala Lys 
        995                 1000                 1005             


Ala Phe  Cys Leu Glu Ala Leu  Lys Leu Thr Thr Lys  Leu Gln Ile 
    1010                 1015                 1020             


Pro Arg  Gln Cys Ala Leu Phe  Leu Val Leu Lys Gly  Glu Leu Glu 
    1025                 1030                 1035             


Leu Ala  Arg Asn Asp Ile Asp  Leu Cys Gln Ser Asp  Leu Gln Gln 
    1040                 1045                 1050             


Val Leu  Phe Leu Leu Glu Ser  Cys Thr Glu Phe Gly  Gly Val Thr 
    1055                 1060                 1065             


Gln His  Leu Asp Ser Val Lys  Lys Val His Leu Gln  Lys Gly Lys 
    1070                 1075                 1080             


Gln Gln  Ala Gln Val Pro Cys  Pro Pro Gln Leu Pro  Glu Glu Glu 
    1085                 1090                 1095             


Leu Phe  Leu Arg Gly Pro Ala  Leu Glu Leu Val Ala  Thr Val Ala 
    1100                 1105                 1110             


Lys Glu  Pro Gly Pro Ile Ala  Pro Ser Thr Asn Ser  Ser Pro Val 
    1115                 1120                 1125             


Leu Lys  Thr Lys Pro Gln Pro  Ile Pro Asn Phe Leu  Ser His Ser 
    1130                 1135                 1140             


Pro Thr  Cys Asp Cys Ser Leu  Cys Ala Ser Pro Val  Leu Thr Ala 
    1145                 1150                 1155             


Val Cys  Leu Arg Trp Val Leu  Val Thr Ala Gly Val  Arg Leu Ala 
    1160                 1165                 1170             


Met Gly  His Gln Ala Gln Gly  Leu Asp Leu Leu Gln  Val Val Leu 
    1175                 1180                 1185             


Lys Gly  Cys Pro Glu Ala Ala  Glu Arg Leu Thr Gln  Ala Leu Gln 
    1190                 1195                 1200             


Ala Ser  Leu Asn His Lys Thr  Pro Pro Ser Leu Val  Pro Ser Leu 
    1205                 1210                 1215             


Leu Asp  Glu Ile Leu Ala Gln  Ala Tyr Thr Leu Leu  Ala Leu Glu 
    1220                 1225                 1230             


Gly Leu  Asn Gln Pro Ser Asn  Glu Ser Leu Gln Lys  Val Leu Gln 
    1235                 1240                 1245             


Ser Gly  Leu Lys Phe Val Ala  Ala Arg Ile Pro His  Leu Glu Pro 
    1250                 1255                 1260             


Trp Arg  Ala Ser Leu Leu Leu  Ile Trp Ala Leu Thr  Lys Leu Gly 
    1265                 1270                 1275             


Gly Leu  Ser Cys Cys Thr Thr  Gln Leu Phe Ala Ser  Ser Trp Gly 
    1280                 1285                 1290             


Trp Gln  Pro Pro Leu Ile Lys  Ser Val Pro Gly Ser  Glu Pro Ser 
    1295                 1300                 1305             


Lys Thr  Gln Gly Gln Lys Arg  Ser Gly Arg Gly Arg  Gln Lys Leu 
    1310                 1315                 1320             


Ala Ser  Ala Pro Leu Arg Leu  Asn Asn Thr Ser Gln  Lys Gly Leu 
    1325                 1330                 1335             


Glu Gly  Arg Gly Leu Pro Cys  Thr Pro Lys Pro Pro  Asp Arg Ile 
    1340                 1345                 1350             


Arg Gln  Ala Gly Pro His Val  Pro Phe Thr Val Phe  Glu Glu Val 
    1355                 1360                 1365             


Cys Pro  Thr Glu Ser Lys Pro  Glu Val Pro Gln Ala  Pro Arg Val 
    1370                 1375                 1380             


Gln Gln  Arg Val Gln Thr Arg  Leu Lys Val Asn Phe  Ser Asp Asp 
    1385                 1390                 1395             


Ser Asp  Leu Glu Asp Pro Val  Ser Ala Glu Ala Trp  Leu Ala Glu 
    1400                 1405                 1410             


Glu Pro  Lys Arg Arg Gly Thr  Ala Ser Arg Gly Arg  Gly Arg Ala 
    1415                 1420                 1425             


Arg Lys  Gly Leu Ser Leu Lys  Thr Asp Ala Val Val  Ala Pro Gly 
    1430                 1435                 1440             


Ser Ala  Pro Gly Asn Pro Gly  Leu Asn Gly Arg Ser  Arg Arg Ala 
    1445                 1450                 1455             


Lys Lys  Val Ala Ser Arg His  Cys Glu Glu Arg Arg  Pro Gln Arg 
    1460                 1465                 1470             


Ala Ser  Asp Gln Ala Arg Pro  Gly Pro Glu Ile Met  Arg Thr Ile 
    1475                 1480                 1485             


Pro Glu  Glu Glu Leu Thr Asp  Asn Trp Arg Lys Met  Ser Phe Glu 
    1490                 1495                 1500             


Ile Leu  Arg Gly Ser Asp Gly  Glu Asp Ser Ala Ser  Gly Gly Lys 
    1505                 1510                 1515             


Thr Pro  Ala Pro Gly Pro Glu  Ala Ala Ser Gly Glu  Trp Glu Leu 
    1520                 1525                 1530             


Leu Arg  Leu Asp Ser Ser Lys  Lys Lys Leu Pro Ser  Pro Cys Pro 
    1535                 1540                 1545             


Asp Lys  Glu Ser Asp Lys Asp  Leu Gly Pro Arg Leu  Arg Leu Pro 
    1550                 1555                 1560             


Ser Ala  Pro Val Ala Thr Gly  Leu Ser Thr Leu Asp  Ser Ile Cys 
    1565                 1570                 1575             


Asp Ser  Leu Ser Val Ala Phe  Arg Gly Ile Ser His  Cys Pro Pro 
    1580                 1585                 1590             


Ser Gly  Leu Tyr Ala His Leu  Cys Arg Phe Leu Ala  Leu Cys Leu 
    1595                 1600                 1605             


Gly His  Arg Asp Pro Tyr Ala  Thr Ala Phe Leu Val  Thr Glu Ser 
    1610                 1615                 1620             


Val Ser  Ile Thr Cys Arg His  Gln Leu Leu Thr His  Leu His Arg 
    1625                 1630                 1635             


Gln Leu  Ser Lys Ala Gln Lys  His Arg Gly Ser Leu  Glu Ile Ala 
    1640                 1645                 1650             


Asp Gln  Leu Gln Gly Leu Ser  Leu Gln Glu Met Pro  Gly Asp Val 
    1655                 1660                 1665             


Pro Leu  Ala Arg Ile Gln Arg  Leu Phe Ser Phe Arg  Ala Leu Glu 
    1670                 1675                 1680             


Ser Gly  His Phe Pro Gln Pro  Glu Lys Glu Ser Phe  Gln Glu Arg 
    1685                 1690                 1695             


Leu Ala  Leu Ile Pro Ser Gly  Val Thr Val Cys Val  Leu Ala Leu 
    1700                 1705                 1710             


Ala Thr  Leu Gln Pro Gly Thr  Val Gly Asn Thr Leu  Leu Leu Thr 
    1715                 1720                 1725             


Arg Leu  Glu Lys Asp Ser Pro  Pro Val Ser Val Gln  Ile Pro Thr 
    1730                 1735                 1740             


Gly Gln  Asn Lys Leu His Leu  Arg Ser Val Leu Asn  Glu Phe Asp 
    1745                 1750                 1755             


Ala Ile  Gln Lys Ala Gln Lys  Glu Asn Ser Ser Cys  Thr Asp Lys 
    1760                 1765                 1770             


Arg Glu  Trp Trp Thr Gly Arg  Leu Ala Leu Asp His  Arg Met Glu 
    1775                 1780                 1785             


Val Leu  Ile Ala Ser Leu Glu  Lys Ser Val Leu Gly  Cys Trp Lys 
    1790                 1795                 1800             


Gly Leu  Leu Leu Pro Ser Ser  Glu Glu Pro Gly Pro  Ala Gln Glu 
    1805                 1810                 1815             


Ala Ser  Arg Leu Gln Glu Leu  Leu Gln Asp Cys Gly  Trp Lys Tyr 
    1820                 1825                 1830             


Pro Asp  Arg Thr Leu Leu Lys  Ile Met Leu Ser Gly  Ala Gly Ala 
    1835                 1840                 1845             


Leu Thr  Pro Gln Asp Ile Gln  Ala Leu Ala Tyr Gly  Leu Cys Pro 
    1850                 1855                 1860             


Thr Gln  Pro Glu Arg Ala Gln  Glu Leu Leu Asn Glu  Ala Val Gly 
    1865                 1870                 1875             


Arg Leu  Gln Gly Leu Thr Val  Pro Ser Asn Ser His  Leu Val Leu 
    1880                 1885                 1890             


Val Leu  Asp Lys Asp Leu Gln  Lys Leu Pro Trp Glu  Ser Met Pro 
    1895                 1900                 1905             


Ser Leu  Gln Ala Leu Pro Val  Thr Arg Leu Pro Ser  Phe Arg Phe 
    1910                 1915                 1920             


Leu Leu  Ser Tyr Ser Ile Ile  Lys Glu Tyr Gly Ala  Ser Pro Val 
    1925                 1930                 1935             


Leu Ser  Gln Gly Val Asp Pro  Arg Ser Thr Phe Tyr  Val Leu Asn 
    1940                 1945                 1950             


Pro His  Asn Asn Leu Ser Ser  Thr Glu Glu Gln Phe  Arg Ala Asn 
    1955                 1960                 1965             


Phe Ser  Ser Glu Ala Gly Trp  Arg Gly Val Val Gly  Glu Val Pro 
    1970                 1975                 1980             


Arg Pro  Glu Gln Val Gln Glu  Ala Leu Thr Lys His  Asp Leu Tyr 
    1985                 1990                 1995             


Ile Tyr  Ala Gly His Gly Ala  Gly Ala Arg Phe Leu  Asp Gly Gln 
    2000                 2005                 2010             


Ala Val  Leu Arg Leu Ser Cys  Arg Ala Val Ala Leu  Leu Phe Gly 
    2015                 2020                 2025             


Cys Ser  Ser Ala Ala Leu Ala  Val Arg Gly Asn Leu  Glu Gly Ala 
    2030                 2035                 2040             


Gly Ile  Val Leu Lys Tyr Ile  Met Ala Gly Cys Pro  Leu Phe Leu 
    2045                 2050                 2055             


Gly Asn  Leu Trp Asp Val Thr  Asp Arg Asp Ile Asp  Arg Tyr Thr 
    2060                 2065                 2070             


Glu Ala  Leu Leu Gln Gly Trp  Leu Gly Ala Gly Pro  Gly Ala Pro 
    2075                 2080                 2085             


Leu Leu  Tyr Tyr Val Asn Gln  Ala Arg Gln Ala Pro  Arg Leu Lys 
    2090                 2095                 2100             


Tyr Leu  Ile Gly Ala Ala Pro  Ile Ala Tyr Gly Leu  Pro Val Ser 
    2105                 2110                 2115             


Leu Arg  
    2120 


<210> 48
<211> 6641
<212> DNA
<213> Homo sapiens

<400> 48
ggttacattt tggatcctcg cggagtactg gtcaggcggt taagtcctgt acctaggaaa       60

gagggcgagc tctggggcgc tctccggtgt catgaggagc ttcaaaagag tcaactttgg      120

gactctgcta agcagccaga aggaggctga agagttgctg cccgccttga aggagttcct      180

gtccaaccct ccagctggtt ttcccagcag ccgatctgat gctgagagga gacaagcttg      240

tgatgccatc ctgagggctt gcaaccagca gctgactgct aagctagctt gccctaggca      300

tctggggagc ctgctggagc tggcagagct ggcctgtgat ggctacttag tgtctacccc      360

acagcgtcct cccctctacc tggaacgaat tctctttgtc ttactgcgga atgctgctgc      420

acaaggaagc ccagaggcca cactccgcct tgctcagccc ctccatgcct gcttggtgca      480

gtgctctcgc gaggctgctc cccaggacta tgaggccgtg gctcggggca gcttttctct      540

gctttggaag ggggcagaag ccctgttgga acggcgagct gcatttgcag ctcggctgaa      600

ggccttgagc ttcctagtac tcttggagga tgaaagtacc ccttgtgagg ttcctcactt      660

tgcttctcca acagcctgtc gagcggtagc tgcccatcag ctatttgatg ccagtggcca      720

tggtctaaat gaagcagatg ctgatttcct agatgacctg ctctccaggc acgtgatcag      780

agccttggtg ggtgagagag ggagctcttc tgggcttctt tctccccaga gggccctctg      840

cctcttggag ctcaccttgg aacactgccg tcgcttttgc tggagccgcc accatgacaa      900

agccatcagc gcagtggaga aggctcacag ttacctaagg aacaccaatc tagcccctag      960

ccttcagcta tgtcagctgg gggttaagct gctgcaggtt ggggaggaag gacctcaggc     1020

agtggccaag cttctgatca aggcatcagc tgtcctgagc aagagtatgg aggcaccatc     1080

acccccactt cgggcattgt atgagagctg ccagttcttc ctttcaggcc tggaacgagg     1140

caccaagagg cgctatagac ttgatgccat tctgagcctc tttgcttttc ttggagggta     1200

ctgctctctt ctgcagcagc tgcgggatga tggtgtgtat gggggctcct ccaagcaaca     1260

gcagtctttt cttcagatgt actttcaggg acttcacctc tacactgtgg tggtttatga     1320

ctttgcccaa ggctgtcaga tagttgattt ggctgacctg acccaactag tggacagttg     1380

taaatctacc gttgtctgga tgctggaggc cttagagggc ctgtcgggcc aagagctgac     1440

ggaccacatg gggatgaccg cttcttacac cagtaatttg gcctacagct tctatagtca     1500

caagctctat gccgaggcct gtgccatctc tgagccgctc tgtcagcacc tgggtttggt     1560

gaagccaggc acttatcccg aggtgcctcc tgagaagttg cacaggtgct tccggctaca     1620

agtagagagt ttgaagaaac tgggtaaaca ggcccagggc tgcaagatgg tgattttgtg     1680

gctggcagcc ctgcaaccct gtagccctga acacatggct gagccagtca ctttctgggt     1740

tcgggtcaag atggatgcgg ccagggctgg agacaaggag ctacagctaa agactctgcg     1800

agacagcctc agtggctggg acccggagac cctggccctc ctgctgaggg aggagctgca     1860

ggcctacaag gcggtgcggg ccgacactgg acaggaacgc ttcaacatca tctgtgacct     1920

cctggagctg agccccgagg agacaccagc cggggcctgg gcacgagcca cccacctggt     1980

agaactggct caggtgctct gctaccacga ctttacgcag cagaccaact gctctgctct     2040

ggatgctatc cgggaagccc tgcagcttct ggactctgtg aggcctgagg cccaggccag     2100

agatcagctt ctggacgata aagcacaggc cttgctgtgg ctttacatct gtactctgga     2160

agccaaaatg caggaaggta tcgagcggga tcggagagcc caggcccctg gtaacttgga     2220

ggaatttgaa gtcaatgacc tgaactatga agataaactc caggaagatc gtttcctata     2280

cagtaacatt gccttcaacc tggctgcaga tgctgctcag tccaaatgcc tggaccaagc     2340

cctggccctg tggaaggagc tgcttacaaa ggggcaggcc ccagctgtac ggtgtctcca     2400

gcagacagca gcctcactgc agatcctagc agccctctac cagctggtgg caaagcccat     2460

gcaggctctg gaggtcctcc tgctgctacg gattgtctct gagagactga aggaccactc     2520

gaaggcagct ggctcctcct gccacatcac ccagctcctc ctgaccctcg gctgtcccag     2580

ctatgcccag ttacacctgg aagaggcagc atcgagcctg aagcatctcg atcagactac     2640

tgacacatac ctgctccttt ccctgacctg tgatctgctt cgaagtcaac tctactggac     2700

tcaccagaag gtgaccaagg gtgtctctct gctgctgtct gtgcttcggg atcctgccct     2760

ccagaagtcc tccaaggctt ggtacttgct gcgtgtccag gtcctgcagc tggtggcagc     2820

ttaccttagc ctcccgtcaa acaacctctc acactccctg tgggagcagc tctgtgccca     2880

aggctggcag acacctgaga tagctctcat agactcccat aagctcctcc gaagcatcat     2940

cctcctgctg atgggcagtg acattctctc aactcagaaa gcagctgtgg agacatcgtt     3000

tttggactat ggtgaaaatc tggtacaaaa atggcaggtt ctttcagagg tgctgagctg     3060

ctcagagaag ctggtctgcc acctgggccg cctgggtagt gtgagtgaag ccaaggcctt     3120

ttgcttggag gccctaaaac ttacaacaaa gctgcagata ccacgccagt gtgccctgtt     3180

cctggtgctg aagggcgagc tggagctggc ccgcaatgac attgatctct gtcagtcgga     3240

cctgcagcag gttctgttct tgcttgagtc ttgcacagag tttggtgggg tgactcagca     3300

cctggactct gtgaagaagg tccacctgca gaaggggaag cagcaggccc aggtcccctg     3360

tcctccacag ctcccagagg aggagctctt cctaagaggc cctgctctag agctggtggc     3420

cactgtggcc aaggagcctg gccccatagc accttctaca aactcctccc cagtcttgaa     3480

aaccaagccc cagcccatac ccaacttcct gtcccattca cccacctgtg actgctcgct     3540

ctgcgccagc cctgtcctca cagcagtctg tctgcgctgg gtattggtca cggcaggggt     3600

gaggctggcc atgggccacc aagcccaggg tctggatctg ctgcaggtcg tgctgaaggg     3660

ctgtcctgaa gccgctgagc gcctcaccca agctctccaa gcttccctga atcataaaac     3720

acccccctcc ttggttccaa gcctcttgga tgagatcttg gctcaagcat acacactgtt     3780

ggcactggag ggcctgaacc agccatcaaa cgagagcctg cagaaggttc tacagtcagg     3840

gctgaagttt gtagcagcac ggatacccca cctagagccc tggcgagcca gcctgctctt     3900

gatttgggcc ctcacaaaac taggtggcct cagctgctgt actacccaac tttttgcaag     3960

ctcctggggc tggcagccac cattaataaa aagtgtccct ggctcagagc cctctaagac     4020

tcagggccaa aaacgttctg gacgagggcg ccaaaagtta gcctctgctc ccctgcgcct     4080

caataatacc tctcagaaag gtctggaagg tagaggactg ccctgcacac ctaaaccccc     4140

agaccggatc aggcaagctg gccctcatgt ccccttcacg gtgtttgagg aagtctgccc     4200

tacagagagc aagcctgaag taccccaggc ccccagggta caacagagag tccagacgcg     4260

cctcaaggtg aacttcagtg atgacagtga cttggaagac cctgtctcag ctgaggcctg     4320

gctggcagag gagcctaaga gacggggcac tgcttcccgg ggccgggggc gagcaaggaa     4380

gggcctgagc ctaaagacgg atgccgtggt tgccccaggt agtgcccctg ggaaccctgg     4440

cctgaatggc aggagccgga gggccaagaa ggtggcatca agacattgtg aggagcggcg     4500

tccccagagg gccagtgacc aggccaggcc tggccctgag atcatgagga ccatccctga     4560

ggaagaactg actgacaact ggagaaaaat gagctttgag atcctcaggg gctctgacgg     4620

ggaagactca gcctcaggtg ggaagactcc agctccgggc cctgaggcag cttctggaga     4680

atgggagctg ctgaggctgg attccagcaa gaagaagctg cccagcccat gcccagacaa     4740

ggagagtgac aaggaccttg gtcctcggct ccggctcccc tcagcccccg tagccactgg     4800

tctttctacc ctggactcca tctgtgactc cctgagtgtt gctttccggg gcattagtca     4860

ctgtcctcct agtgggctct atgcccacct ctgccgcttc ctggccttgt gcctgggcca     4920

ccgggatcct tatgccactg ctttccttgt caccgagtct gtctccatca cctgtcgcca     4980

ccagctgctc acccacctcc acagacagct cagcaaggcc cagaagcacc gaggatcact     5040

tgaaatagca gaccagctgc aggggctgag ccttcaggag atgcctggag atgtccccct     5100

ggcccgcatc cagcgcctct tttccttcag ggctttggaa tctggccact tcccccagcc     5160

tgaaaaggag agtttccagg agcgcctggc tctgatcccc agtggggtga ctgtgtgtgt     5220

gttggccctg gccaccctcc agcccggaac cgtgggcaac accctcctgc tgacccggct     5280

ggaaaaggac agtcccccag tcagtgtgca gattcccact ggccagaaca agcttcatct     5340

gcgttcagtc ctgaatgagt ttgatgccat ccagaaggca cagaaagaga acagcagctg     5400

tactgacaag cgagaatggt ggacagggcg gctggcactg gaccacagga tggaggttct     5460

catcgcttcc ctagagaagt ctgtgctggg ctgctggaag gggctgctgc tgccgtccag     5520

tgaggagccc ggccctgccc aggaggcctc ccgcctacag gagctgctac aggactgtgg     5580

ctggaaatat cctgaccgca ctctgctgaa aatcatgctc agtggtgccg gtgccctcac     5640

ccctcaggac attcaggccc tggcctacgg gctgtgccca acccagccag agcgagccca     5700

ggagctcctg aatgaggcag taggacgtct acagggcctg acagtaccaa gcaatagcca     5760

ccttgtcttg gtcctagaca aggacttgca gaagctgccg tgggaaagca tgcccagcct     5820

ccaagcactg cctgtcaccc ggctgccctc cttccgcttc ctactcagct actccatcat     5880

caaagagtat ggggcctcgc cagtgctgag tcaaggggtg gatccacgaa gtaccttcta     5940

tgtcctgaac cctcacaata acctgtcaag cacagaggag caatttcgag ccaatttcag     6000

cagtgaagct ggctggagag gagtggttgg ggaggtgcca agacctgaac aggtgcagga     6060

agccctgaca aagcatgatt tgtatatcta tgcagggcat ggggctggtg cccgcttcct     6120

tgatgggcag gctgtcctgc ggctgagctg tcgggcagtg gccctgctgt ttggctgtag     6180

cagtgcggcc ctggctgtgc gtggaaacct ggagggggct ggcatcgtgc tcaagtacat     6240

catggctggt tgccccttgt ttctgggtaa tctctgggat gtgactgacc gcgacattga     6300

ccgctacacg gaagctctgc tgcaaggctg gcttggagca ggcccagggg ccccccttct     6360

ctactatgta aaccaggccc gccaagctcc ccgactcaag tatcttattg gggctgcacc     6420

tatagcctat ggcttgcctg tctctctgcg gtaaccccat ggagctgtct tattgatgct     6480

agaagcctca taactgttct acctccaagg ttagatttaa tccttaggat aactctttta     6540

aagtgatttt ccccagtgtt ttatatgaaa catttccttt tgatttaacc tcagtataat     6600

aaagatacat catttaaacc ctgaaaaaaa aaaaaaaaaa a                         6641


<210> 49
<211> 707
<212> PRT
<213> Homo sapiens

<400> 49
Met Ser Leu Trp Gln Pro Leu Val Leu Val Leu Leu Val Leu Gly Cys 
1               5                   10                  15      


Cys Phe Ala Ala Pro Arg Gln Arg Gln Ser Thr Leu Val Leu Phe Pro 
            20                  25                  30          


Gly Asp Leu Arg Thr Asn Leu Thr Asp Arg Gln Leu Ala Glu Glu Tyr 
        35                  40                  45              


Leu Tyr Arg Tyr Gly Tyr Thr Arg Val Ala Glu Met Arg Gly Glu Ser 
    50                  55                  60                  


Lys Ser Leu Gly Pro Ala Leu Leu Leu Leu Gln Lys Gln Leu Ser Leu 
65                  70                  75                  80  


Pro Glu Thr Gly Glu Leu Asp Ser Ala Thr Leu Lys Ala Met Arg Thr 
                85                  90                  95      


Pro Arg Cys Gly Val Pro Asp Leu Gly Arg Phe Gln Thr Phe Glu Gly 
            100                 105                 110         


Asp Leu Lys Trp His His His Asn Ile Thr Tyr Trp Ile Gln Asn Tyr 
        115                 120                 125             


Ser Glu Asp Leu Pro Arg Ala Val Ile Asp Asp Ala Phe Ala Arg Ala 
    130                 135                 140                 


Phe Ala Leu Trp Ser Ala Val Thr Pro Leu Thr Phe Thr Arg Val Tyr 
145                 150                 155                 160 


Ser Arg Asp Ala Asp Ile Val Ile Gln Phe Gly Val Ala Glu His Gly 
                165                 170                 175     


Asp Gly Tyr Pro Phe Asp Gly Lys Asp Gly Leu Leu Ala His Ala Phe 
            180                 185                 190         


Pro Pro Gly Pro Gly Ile Gln Gly Asp Ala His Phe Asp Asp Asp Glu 
        195                 200                 205             


Leu Trp Ser Leu Gly Lys Gly Val Val Val Pro Thr Arg Phe Gly Asn 
    210                 215                 220                 


Ala Asp Gly Ala Ala Cys His Phe Pro Phe Ile Phe Glu Gly Arg Ser 
225                 230                 235                 240 


Tyr Ser Ala Cys Thr Thr Asp Gly Arg Ser Asp Gly Leu Pro Trp Cys 
                245                 250                 255     


Ser Thr Thr Ala Asn Tyr Asp Thr Asp Asp Arg Phe Gly Phe Cys Pro 
            260                 265                 270         


Ser Glu Arg Leu Tyr Thr Gln Asp Gly Asn Ala Asp Gly Lys Pro Cys 
        275                 280                 285             


Gln Phe Pro Phe Ile Phe Gln Gly Gln Ser Tyr Ser Ala Cys Thr Thr 
    290                 295                 300                 


Asp Gly Arg Ser Asp Gly Tyr Arg Trp Cys Ala Thr Thr Ala Asn Tyr 
305                 310                 315                 320 


Asp Arg Asp Lys Leu Phe Gly Phe Cys Pro Thr Arg Ala Asp Ser Thr 
                325                 330                 335     


Val Met Gly Gly Asn Ser Ala Gly Glu Leu Cys Val Phe Pro Phe Thr 
            340                 345                 350         


Phe Leu Gly Lys Glu Tyr Ser Thr Cys Thr Ser Glu Gly Arg Gly Asp 
        355                 360                 365             


Gly Arg Leu Trp Cys Ala Thr Thr Ser Asn Phe Asp Ser Asp Lys Lys 
    370                 375                 380                 


Trp Gly Phe Cys Pro Asp Gln Gly Tyr Ser Leu Phe Leu Val Ala Ala 
385                 390                 395                 400 


His Glu Phe Gly His Ala Leu Gly Leu Asp His Ser Ser Val Pro Glu 
                405                 410                 415     


Ala Leu Met Tyr Pro Met Tyr Arg Phe Thr Glu Gly Pro Pro Leu His 
            420                 425                 430         


Lys Asp Asp Val Asn Gly Ile Arg His Leu Tyr Gly Pro Arg Pro Glu 
        435                 440                 445             


Pro Glu Pro Arg Pro Pro Thr Thr Thr Thr Pro Gln Pro Thr Ala Pro 
    450                 455                 460                 


Pro Thr Val Cys Pro Thr Gly Pro Pro Thr Val His Pro Ser Glu Arg 
465                 470                 475                 480 


Pro Thr Ala Gly Pro Thr Gly Pro Pro Ser Ala Gly Pro Thr Gly Pro 
                485                 490                 495     


Pro Thr Ala Gly Pro Ser Thr Ala Thr Thr Val Pro Leu Ser Pro Val 
            500                 505                 510         


Asp Asp Ala Cys Asn Val Asn Ile Phe Asp Ala Ile Ala Glu Ile Gly 
        515                 520                 525             


Asn Gln Leu Tyr Leu Phe Lys Asp Gly Lys Tyr Trp Arg Phe Ser Glu 
    530                 535                 540                 


Gly Arg Gly Ser Arg Pro Gln Gly Pro Phe Leu Ile Ala Asp Lys Trp 
545                 550                 555                 560 


Pro Ala Leu Pro Arg Lys Leu Asp Ser Val Phe Glu Glu Arg Leu Ser 
                565                 570                 575     


Lys Lys Leu Phe Phe Phe Ser Gly Arg Gln Val Trp Val Tyr Thr Gly 
            580                 585                 590         


Ala Ser Val Leu Gly Pro Arg Arg Leu Asp Lys Leu Gly Leu Gly Ala 
        595                 600                 605             


Asp Val Ala Gln Val Thr Gly Ala Leu Arg Ser Gly Arg Gly Lys Met 
    610                 615                 620                 


Leu Leu Phe Ser Gly Arg Arg Leu Trp Arg Phe Asp Val Lys Ala Gln 
625                 630                 635                 640 


Met Val Asp Pro Arg Ser Ala Ser Glu Val Asp Arg Met Phe Pro Gly 
                645                 650                 655     


Val Pro Leu Asp Thr His Asp Val Phe Gln Tyr Arg Glu Lys Ala Tyr 
            660                 665                 670         


Phe Cys Gln Asp Arg Phe Tyr Trp Arg Val Ser Ser Arg Ser Glu Leu 
        675                 680                 685             


Asn Gln Val Asp Gln Val Gly Tyr Val Thr Tyr Asp Ile Leu Gln Cys 
    690                 695                 700                 


Pro Glu Asp 
705         


<210> 50
<211> 2387
<212> DNA
<213> Homo sapiens

<400> 50
agacacctct gccctcacca tgagcctctg gcagcccctg gtcctggtgc tcctggtgct       60

gggctgctgc tttgctgccc ccagacagcg ccagtccacc cttgtgctct tccctggaga      120

cctgagaacc aatctcaccg acaggcagct ggcagaggaa tacctgtacc gctatggtta      180

cactcgggtg gcagagatgc gtggagagtc gaaatctctg gggcctgcgc tgctgcttct      240

ccagaagcaa ctgtccctgc ccgagaccgg tgagctggat agcgccacgc tgaaggccat      300

gcgaacccca cggtgcgggg tcccagacct gggcagattc caaacctttg agggcgacct      360

caagtggcac caccacaaca tcacctattg gatccaaaac tactcggaag acttgccgcg      420

ggcggtgatt gacgacgcct ttgcccgcgc cttcgcactg tggagcgcgg tgacgccgct      480

caccttcact cgcgtgtaca gccgggacgc agacatcgtc atccagtttg gtgtcgcgga      540

gcacggagac gggtatccct tcgacgggaa ggacgggctc ctggcacacg cctttcctcc      600

tggccccggc attcagggag acgcccattt cgacgatgac gagttgtggt ccctgggcaa      660

gggcgtcgtg gttccaactc ggtttggaaa cgcagatggc gcggcctgcc acttcccctt      720

catcttcgag ggccgctcct actctgcctg caccaccgac ggtcgctccg acggcttgcc      780

ctggtgcagt accacggcca actacgacac cgacgaccgg tttggcttct gccccagcga      840

gagactctac acccaggacg gcaatgctga tgggaaaccc tgccagtttc cattcatctt      900

ccaaggccaa tcctactccg cctgcaccac ggacggtcgc tccgacggct accgctggtg      960

cgccaccacc gccaactacg accgggacaa gctcttcggc ttctgcccga cccgagctga     1020

ctcgacggtg atggggggca actcggcggg ggagctgtgc gtcttcccct tcactttcct     1080

gggtaaggag tactcgacct gtaccagcga gggccgcgga gatgggcgcc tctggtgcgc     1140

taccacctcg aactttgaca gcgacaagaa gtggggcttc tgcccggacc aaggatacag     1200

tttgttcctc gtggcggcgc atgagttcgg ccacgcgctg ggcttagatc attcctcagt     1260

gccggaggcg ctcatgtacc ctatgtaccg cttcactgag gggcccccct tgcataagga     1320

cgacgtgaat ggcatccggc acctctatgg tcctcgccct gaacctgagc cacggcctcc     1380

aaccaccacc acaccgcagc ccacggctcc cccgacggtc tgccccaccg gaccccccac     1440

tgtccacccc tcagagcgcc ccacagctgg ccccacaggt cccccctcag ctggccccac     1500

aggtcccccc actgctggcc cttctacggc cactactgtg cctttgagtc cggtggacga     1560

tgcctgcaac gtgaacatct tcgacgccat cgcggagatt gggaaccagc tgtatttgtt     1620

caaggatggg aagtactggc gattctctga gggcaggggg agccggccgc agggcccctt     1680

ccttatcgcc gacaagtggc ccgcgctgcc ccgcaagctg gactcggtct ttgaggagcg     1740

gctctccaag aagcttttct tcttctctgg gcgccaggtg tgggtgtaca caggcgcgtc     1800

ggtgctgggc ccgaggcgtc tggacaagct gggcctggga gccgacgtgg cccaggtgac     1860

cggggccctc cggagtggca gggggaagat gctgctgttc agcgggcggc gcctctggag     1920

gttcgacgtg aaggcgcaga tggtggatcc ccggagcgcc agcgaggtgg accggatgtt     1980

ccccggggtg cctttggaca cgcacgacgt cttccagtac cgagagaaag cctatttctg     2040

ccaggaccgc ttctactggc gcgtgagttc ccggagtgag ttgaaccagg tggaccaagt     2100

gggctacgtg acctatgaca tcctgcagtg ccctgaggac tagggctccc gtcctgcttt     2160

ggcagtgcca tgtaaatccc cactgggacc aaccctgggg aaggagccag tttgccggat     2220

acaaactggt attctgttct ggaggaaagg gaggagtgga ggtgggctgg gccctctctt     2280

ctcacctttg ttttttgttg gagtgtttct aataaacttg gattctctaa cctttaaaaa     2340

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa                   2387


<210> 51
<211> 5058
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (283)..(283)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (2674)..(2674)
<223> Any amino acid

<400> 51
Met Gly His Ala Gly Cys Gln Phe Lys Ala Leu Leu Trp Lys Asn Trp 
1               5                   10                  15      


Leu Cys Arg Leu Arg Asn Pro Val Leu Phe Leu Ala Glu Phe Phe Trp 
            20                  25                  30          


Pro Cys Ile Leu Phe Val Ile Leu Thr Val Leu Arg Phe Gln Glu Pro 
        35                  40                  45              


Pro Arg Tyr Arg Asp Ile Cys Tyr Leu Gln Pro Arg Asp Leu Pro Ser 
    50                  55                  60                  


Cys Gly Val Ile Pro Phe Val Gln Ser Leu Leu Cys Asn Thr Gly Ser 
65                  70                  75                  80  


Arg Cys Arg Asn Phe Ser Tyr Glu Gly Ser Met Glu His His Phe Arg 
                85                  90                  95      


Leu Ser Arg Phe Gln Thr Ala Ala Asp Pro Lys Lys Val Asn Asn Leu 
            100                 105                 110         


Ala Phe Leu Lys Glu Ile Gln Asp Leu Ala Glu Glu Ile His Gly Met 
        115                 120                 125             


Met Asp Lys Ala Lys Asn Leu Lys Arg Leu Trp Val Glu Arg Ser Asn 
    130                 135                 140                 


Thr Pro Asp Ser Ser Tyr Gly Ser Ser Phe Phe Thr Met Asp Leu Asn 
145                 150                 155                 160 


Lys Thr Glu Glu Val Ile Leu Lys Leu Glu Ser Leu His Gln Gln Pro 
                165                 170                 175     


His Ile Trp Asp Phe Leu Leu Leu Leu Pro Arg Leu His Thr Ser His 
            180                 185                 190         


Asp His Val Glu Asp Gly Met Asp Val Ala Val Asn Leu Leu Gln Thr 
        195                 200                 205             


Ile Leu Asn Ser Leu Ile Ser Leu Glu Asp Leu Asp Trp Leu Pro Leu 
    210                 215                 220                 


Asn Gln Thr Phe Ser Gln Val Ser Glu Leu Val Leu Asn Val Thr Ile 
225                 230                 235                 240 


Ser Thr Leu Thr Phe Leu Gln Gln His Gly Val Ala Val Thr Glu Pro 
                245                 250                 255     


Val Tyr His Leu Ser Met Gln Asn Ile Val Trp Asp Pro Gln Lys Val 
            260                 265                 270         


Gln Tyr Asp Leu Lys Ser Gln Phe Gly Phe Xaa Asp Leu His Thr Glu 
        275                 280                 285             


Gln Ile Leu Asn Ser Ser Ala Glu Leu Lys Glu Ile Pro Thr Asp Thr 
    290                 295                 300                 


Ser Leu Glu Lys Met Val Cys Ser Val Leu Ser Ser Thr Ser Glu Asp 
305                 310                 315                 320 


Glu Ala Glu Lys Trp Gly His Val Gly Gly Cys His Pro Lys Trp Ser 
                325                 330                 335     


Glu Ala Lys Asn Tyr Leu Val His Ala Val Ser Trp Leu Arg Val Tyr 
            340                 345                 350         


Gln Gln Val Phe Val Gln Trp Gln Gln Gly Ser Leu Leu Gln Lys Thr 
        355                 360                 365             


Leu Thr Gly Met Gly His Ser Leu Glu Ala Leu Arg Asn Gln Phe Glu 
    370                 375                 380                 


Glu Glu Ser Lys Pro Trp Lys Val Val Glu Ala Leu His Thr Ala Leu 
385                 390                 395                 400 


Leu Leu Leu Asn Asp Ser Leu Ser Ala Asp Gly Pro Lys Asp Asn His 
                405                 410                 415     


Thr Phe Pro Lys Ile Leu Gln His Leu Trp Lys Leu Gln Ser Leu Leu 
            420                 425                 430         


Gln Asn Leu Pro Gln Trp Pro Ala Leu Lys Arg Phe Leu Gln Leu Asp 
        435                 440                 445             


Gly Ala Leu Arg Asn Ala Ile Ala Gln Asn Leu His Phe Val Gln Glu 
    450                 455                 460                 


Val Leu Ile Cys Leu Glu Thr Ser Ala Asn Asp Phe Lys Trp Phe Glu 
465                 470                 475                 480 


Leu Asn Gln Leu Lys Leu Glu Lys Asp Val Phe Phe Trp Glu Leu Lys 
                485                 490                 495     


Gln Met Leu Ala Lys Asn Ala Val Cys Pro Asn Gly Arg Phe Ser Glu 
            500                 505                 510         


Lys Glu Val Phe Leu Pro Pro Gly Asn Ser Ser Ile Trp Gly Gly Leu 
        515                 520                 525             


Gln Gly Leu Leu Cys Tyr Cys Asn Ser Ser Glu Thr Ser Val Leu Asn 
    530                 535                 540                 


Lys Leu Leu Gly Ser Val Glu Asp Ala Asp Arg Ile Leu Gln Glu Val 
545                 550                 555                 560 


Ile Thr Trp His Lys Asn Met Ser Val Leu Ile Pro Glu Glu Tyr Leu 
                565                 570                 575     


Asp Trp Gln Glu Leu Glu Met Gln Leu Ser Glu Ala Ser Leu Ser Cys 
            580                 585                 590         


Thr Arg Leu Phe Leu Leu Leu Gly Ala Asp Pro Ser Pro Glu Asn Asp 
        595                 600                 605             


Val Phe Ser Ser Asp Cys Lys His Gln Leu Val Ser Thr Val Ile Phe 
    610                 615                 620                 


His Thr Leu Glu Lys Thr Gln Phe Phe Leu Glu Gln Ala Tyr Tyr Trp 
625                 630                 635                 640 


Lys Ala Phe Lys Lys Phe Ile Arg Lys Thr Cys Glu Val Ala Gln Tyr 
                645                 650                 655     


Val Asn Met Gln Glu Ser Phe Gln Asn Arg Leu Leu Ala Phe Pro Glu 
            660                 665                 670         


Glu Ser Pro Cys Phe Glu Glu Asn Met Asp Trp Lys Met Ile Ser Asp 
        675                 680                 685             


Asn Tyr Phe Gln Phe Leu Asn Asn Leu Leu Lys Ser Pro Thr Ala Ser 
    690                 695                 700                 


Ile Ser Arg Ala Leu Asn Phe Thr Lys His Leu Leu Met Met Glu Lys 
705                 710                 715                 720 


Lys Leu His Thr Leu Glu Asp Glu Gln Met Asn Phe Leu Leu Ser Phe 
                725                 730                 735     


Val Glu Phe Phe Glu Lys Leu Leu Leu Pro Asn Leu Phe Asp Ser Ser 
            740                 745                 750         


Ile Val Pro Ser Phe His Ser Leu Pro Ser Leu Thr Glu Asp Ile Leu 
        755                 760                 765             


Asn Ile Ser Ser Leu Trp Thr Asn His Leu Lys Ser Leu Lys Arg Asp 
    770                 775                 780                 


Pro Ser Ala Thr Asp Ala Gln Lys Leu Leu Glu Phe Gly Asn Glu Val 
785                 790                 795                 800 


Ile Trp Lys Met Gln Thr Leu Gly Ser His Trp Ile Arg Lys Glu Pro 
                805                 810                 815     


Lys Asn Leu Leu Arg Phe Ile Glu Leu Ile Leu Phe Glu Ile Asn Pro 
            820                 825                 830         


Lys Leu Leu Glu Leu Trp Ala Tyr Gly Ile Ser Lys Gly Lys Arg Ala 
        835                 840                 845             


Lys Leu Glu Asn Phe Phe Thr Leu Leu Asn Phe Ser Val Pro Glu Asn 
    850                 855                 860                 


Glu Ile Leu Ser Thr Ser Phe Asn Phe Ser Gln Leu Phe His Ser Asp 
865                 870                 875                 880 


Trp Pro Lys Ser Pro Ala Met Asn Ile Asp Phe Val Arg Leu Ser Glu 
                885                 890                 895     


Ala Ile Ile Thr Ser Leu His Glu Phe Gly Phe Leu Glu Gln Glu Gln 
            900                 905                 910         


Ile Ser Glu Ala Leu Asn Thr Val Tyr Ala Ile Arg Asn Ala Ser Asp 
        915                 920                 925             


Leu Phe Ser Ala Leu Ser Glu Pro Gln Lys Gln Glu Val Asp Lys Ile 
    930                 935                 940                 


Leu Thr His Ile His Leu Asn Val Phe Gln Asp Lys Asp Ser Ala Leu 
945                 950                 955                 960 


Leu Leu Gln Ile Tyr Ser Ser Phe Tyr Arg Tyr Ile Tyr Glu Leu Leu 
                965                 970                 975     


Asn Ile Gln Ser Arg Gly Ser Ser Leu Thr Phe Leu Thr Gln Ile Ser 
            980                 985                 990         


Lys His Ile Leu Asp Ile Ile Lys  Gln Phe Asn Phe Gln  Asn Ile Ser 
        995                 1000                 1005             


Lys Ala  Phe Ala Phe Leu Phe  Lys Thr Ala Glu Val  Leu Gly Gly 
    1010                 1015                 1020             


Ile Ser  Asn Val Ser Tyr Cys  Gln Gln Leu Leu Ser  Ile Phe Asn 
    1025                 1030                 1035             


Phe Leu  Glu Leu Gln Ala Gln  Ser Phe Met Ser Thr  Glu Gly Gln 
    1040                 1045                 1050             


Glu Leu  Glu Val Ile His Thr  Thr Leu Thr Gly Leu  Lys Gln Leu 
    1055                 1060                 1065             


Leu Ile  Ile Asp Glu Asp Phe  Arg Ile Ser Leu Phe  Gln Tyr Met 
    1070                 1075                 1080             


Ser Gln  Phe Phe Asn Ser Ser  Val Glu Asp Leu Leu  Asp Asn Lys 
    1085                 1090                 1095             


Cys Leu  Ile Ser Asp Asn Lys  His Ile Ser Ser Val  Asn Tyr Ser 
    1100                 1105                 1110             


Thr Ser  Glu Glu Ser Ser Phe  Val Phe Pro Leu Ala  Gln Ile Phe 
    1115                 1120                 1125             


Ser Asn  Leu Ser Ala Asn Val  Ser Val Phe Asn Lys  Phe Met Ser 
    1130                 1135                 1140             


Ile His  Cys Thr Val Ser Trp  Leu Gln Met Trp Thr  Glu Ile Trp 
    1145                 1150                 1155             


Glu Thr  Ile Ser Gln Leu Phe  Lys Phe Asp Met Asn  Val Phe Thr 
    1160                 1165                 1170             


Ser Leu  His His Gly Phe Thr  Gln Leu Leu Asp Glu  Leu Glu Asp 
    1175                 1180                 1185             


Asp Val  Lys Val Ser Lys Ser  Cys Gln Gly Ile Leu  Pro Thr His 
    1190                 1195                 1200             


Asn Val  Ala Arg Leu Ile Leu  Asn Leu Phe Lys Asn  Val Thr Gln 
    1205                 1210                 1215             


Ala Asn  Asp Phe His Asn Trp  Glu Asp Phe Leu Asp  Leu Arg Asp 
    1220                 1225                 1230             


Phe Leu  Val Ala Leu Gly Asn  Ala Leu Val Ser Val  Lys Lys Leu 
    1235                 1240                 1245             


Asn Leu  Glu Gln Val Glu Lys  Ser Leu Phe Thr Met  Glu Ala Ala 
    1250                 1255                 1260             


Leu His  Gln Leu Lys Thr Phe  Pro Phe Asn Glu Ser  Thr Ser Arg 
    1265                 1270                 1275             


Glu Phe  Leu Asn Ser Leu Leu  Glu Val Phe Ile Glu  Phe Ser Ser 
    1280                 1285                 1290             


Thr Ser  Glu Tyr Ile Val Arg  Asn Leu Asp Ser Ile  Asn Asp Phe 
    1295                 1300                 1305             


Leu Ser  Asn Asn Leu Thr Asn  Tyr Gly Glu Lys Phe  Glu Asn Ile 
    1310                 1315                 1320             


Ile Thr  Glu Leu Arg Glu Ala  Ile Val Phe Leu Arg  Asn Val Ser 
    1325                 1330                 1335             


His Asp  Arg Asp Leu Phe Ser  Cys Ala Asp Ile Phe  Gln Asn Val 
    1340                 1345                 1350             


Thr Glu  Cys Ile Leu Glu Asp  Gly Phe Leu Tyr Val  Asn Thr Ser 
    1355                 1360                 1365             


Gln Arg  Met Leu Arg Ile Leu  Asp Thr Leu Asn Ser  Thr Phe Ser 
    1370                 1375                 1380             


Ser Glu  Asn Thr Ile Ser Ser  Leu Lys Gly Cys Ile  Val Trp Leu 
    1385                 1390                 1395             


Asp Val  Ile Asn His Leu Tyr  Leu Leu Ser Asn Ser  Ser Phe Ser 
    1400                 1405                 1410             


Gln Gly  Arg Leu Gln Asn Ile  Leu Gly Asn Phe Arg  Asp Ile Glu 
    1415                 1420                 1425             


Asn Lys  Met Asn Ser Ile Leu  Lys Ile Val Thr Trp  Val Leu Asn 
    1430                 1435                 1440             


Ile Lys  Lys Pro Leu Cys Ser  Ser Asn Gly Ser His  Ile Asn Cys 
    1445                 1450                 1455             


Val Asn  Ile Tyr Leu Lys Asp  Val Thr Asp Phe Leu  Asn Ile Val 
    1460                 1465                 1470             


Leu Thr  Thr Val Phe Glu Lys  Glu Lys Lys Pro Lys  Phe Glu Ile 
    1475                 1480                 1485             


Leu Leu  Ala Leu Leu Asn Asp  Ser Thr Lys Gln Val  Arg Met Ser 
    1490                 1495                 1500             


Ile Asn  Asn Leu Thr Thr Asp  Phe Asp Phe Ala Ser  Gln Ser Asn 
    1505                 1510                 1515             


Trp Arg  Tyr Phe Thr Glu Leu  Ile Leu Arg Pro Ile  Glu Met Ser 
    1520                 1525                 1530             


Asp Glu  Ile Pro Asn Gln Phe  Gln Asn Ile Trp Leu  His Leu Ile 
    1535                 1540                 1545             


Thr Leu  Gly Lys Glu Phe Gln  Lys Leu Val Lys Gly  Ile Tyr Phe 
    1550                 1555                 1560             


Asn Ile  Leu Glu Asn Asn Ser  Ser Ser Lys Thr Glu  Asn Leu Leu 
    1565                 1570                 1575             


Asn Ile  Phe Ala Thr Ser Pro  Lys Glu Lys Asp Val  Asn Ser Val 
    1580                 1585                 1590             


Gly Asn  Ser Ile Tyr His Leu  Ala Ser Tyr Leu Ala  Phe Ser Leu 
    1595                 1600                 1605             


Ser His  Asp Leu Gln Asn Ser  Pro Lys Ile Ile Ile  Ser Pro Glu 
    1610                 1615                 1620             


Ile Met  Lys Ala Thr Gly Leu  Gly Ile Gln Leu Ile  Arg Asp Val 
    1625                 1630                 1635             


Phe Asn  Ser Leu Met Pro Val  Val His His Thr Ser  Pro Gln Asn 
    1640                 1645                 1650             


Ala Gly  Tyr Met Gln Ala Leu  Lys Lys Val Thr Ser  Val Met Arg 
    1655                 1660                 1665             


Thr Leu  Lys Lys Ala Asp Ile  Asp Leu Leu Val Asp  Gln Leu Glu 
    1670                 1675                 1680             


Gln Val  Ser Val Asn Leu Met  Asp Phe Phe Lys Asn  Ile Ser Ser 
    1685                 1690                 1695             


Val Gly  Thr Gly Asn Leu Val  Val Asn Leu Leu Val  Gly Leu Met 
    1700                 1705                 1710             


Glu Lys  Phe Ala Asp Ser Ser  His Ser Trp Asn Val  Asn His Leu 
    1715                 1720                 1725             


Leu Gln  Leu Ser Arg Leu Phe  Pro Lys Asp Val Val  Asp Ala Val 
    1730                 1735                 1740             


Ile Asp  Val Tyr Tyr Val Leu  Pro His Ala Val Arg  Leu Leu Gln 
    1745                 1750                 1755             


Gly Val  Pro Gly Lys Asn Ile  Thr Glu Gly Leu Lys  Asp Val Tyr 
    1760                 1765                 1770             


Ser Phe  Thr Leu Leu His Gly  Ile Thr Ile Ser Asn  Ile Thr Lys 
    1775                 1780                 1785             


Glu Asp  Phe Ala Ile Val Ile  Lys Ile Leu Leu Asp  Thr Ile Glu 
    1790                 1795                 1800             


Leu Val  Ser Asp Lys Pro Asp  Ile Ile Ser Glu Ala  Leu Ala Cys 
    1805                 1810                 1815             


Phe Pro  Val Val Trp Cys Trp  Asn His Thr Asn Ser  Gly Phe Arg 
    1820                 1825                 1830             


Gln Asn  Ser Lys Ile Asp Pro  Cys Asn Val His Gly  Leu Met Ser 
    1835                 1840                 1845             


Ser Ser  Phe Tyr Gly Lys Val  Ala Ser Ile Leu Asp  His Phe His 
    1850                 1855                 1860             


Leu Ser  Pro Gln Gly Glu Asp  Ser Pro Cys Ser Asn  Glu Ser Ser 
    1865                 1870                 1875             


Arg Met  Glu Ile Thr Arg Lys  Val Val Cys Ile Ile  His Glu Leu 
    1880                 1885                 1890             


Val Asp  Trp Asn Ser Ile Leu  Leu Glu Leu Ser Glu  Val Phe His 
    1895                 1900                 1905             


Val Asn  Ile Ser Leu Val Lys  Thr Val Gln Lys Phe  Trp His Lys 
    1910                 1915                 1920             


Ile Leu  Pro Phe Val Pro Pro  Ser Ile Asn Gln Thr  Arg Asp Ser 
    1925                 1930                 1935             


Ile Ser  Glu Leu Cys Pro Ser  Gly Ser Ile Lys Gln  Val Ala Leu 
    1940                 1945                 1950             


Gln Ile  Ile Glu Lys Leu Lys  Asn Val Asn Phe Thr  Lys Val Thr 
    1955                 1960                 1965             


Ser Gly  Glu Asn Ile Leu Asp  Lys Leu Ser Ser Leu  Asn Lys Ile 
    1970                 1975                 1980             


Leu Asn  Ile Asn Glu Asp Thr  Glu Thr Ser Val Gln  Asn Ile Ile 
    1985                 1990                 1995             


Ser Ser  Asn Leu Glu Arg Thr  Val Gln Leu Ile Ser  Glu Asp Trp 
    2000                 2005                 2010             


Ser Leu  Glu Lys Ser Thr His  Asn Leu Leu Ser Leu  Phe Met Met 
    2015                 2020                 2025             


Leu Gln  Asn Ala Asn Val Thr  Gly Ser Ser Leu Glu  Ala Leu Ser 
    2030                 2035                 2040             


Ser Phe  Ile Glu Lys Ser Glu  Thr Pro Tyr Asn Phe  Glu Glu Leu 
    2045                 2050                 2055             


Trp Pro  Lys Phe Gln Gln Ile  Met Lys Asp Leu Thr  Gln Asp Phe 
    2060                 2065                 2070             


Arg Ile  Arg His Leu Leu Ser  Glu Met Asn Lys Gly  Ile Lys Ser 
    2075                 2080                 2085             


Ile Asn  Ser Met Ala Leu Gln  Lys Ile Thr Leu Gln  Phe Ala His 
    2090                 2095                 2100             


Phe Leu  Glu Ile Leu Asp Ser  Pro Ser Leu Lys Thr  Leu Glu Ile 
    2105                 2110                 2115             


Ile Glu  Asp Phe Leu Leu Val  Thr Lys Asn Trp Leu  Gln Glu Tyr 
    2120                 2125                 2130             


Ala Asn  Glu Asp Tyr Ser Arg  Met Ile Glu Thr Leu  Phe Ile Pro 
    2135                 2140                 2145             


Val Thr  Asn Glu Ser Ser Thr  Glu Asp Ile Ala Leu  Leu Ala Lys 
    2150                 2155                 2160             


Ala Ile  Ala Thr Phe Trp Gly  Ser Leu Lys Asn Ile  Ser Arg Ala 
    2165                 2170                 2175             


Gly Asn  Phe Asp Val Ala Phe  Leu Thr His Leu Leu  Asn Gln Glu 
    2180                 2185                 2190             


Gln Leu  Thr Asn Phe Ser Val  Val Gln Leu Leu Phe  Glu Asn Ile 
    2195                 2200                 2205             


Leu Ile  Asn Leu Ile Asn Asn  Leu Ala Gly Asn Ser  Gln Glu Ala 
    2210                 2215                 2220             


Ala Trp  Asn Leu Asn Asp Thr  Asp Leu Gln Ile Met  Asn Phe Ile 
    2225                 2230                 2235             


Asn Leu  Ile Leu Asn His Met  Gln Ser Glu Thr Ser  Arg Lys Thr 
    2240                 2245                 2250             


Val Leu  Ser Leu Arg Ser Ile  Val Asp Phe Thr Glu  Gln Phe Leu 
    2255                 2260                 2265             


Lys Thr  Phe Phe Ser Leu Phe  Leu Lys Glu Asp Ser  Glu Asn Lys 
    2270                 2275                 2280             


Ile Ser  Leu Leu Leu Lys Tyr  Phe His Lys Asp Val  Ile Ala Glu 
    2285                 2290                 2295             


Met Ser  Phe Val Pro Lys Asp  Lys Ile Leu Glu Ile  Leu Lys Leu 
    2300                 2305                 2310             


Asp Gln  Phe Leu Thr Leu Met  Ile Gln Asp Arg Leu  Met Asn Ile 
    2315                 2320                 2325             


Phe Ser  Ser Leu Lys Glu Thr  Ile Tyr His Leu Met  Lys Ser Ser 
    2330                 2335                 2340             


Phe Ile  Leu Asp Asn Gly Glu  Phe Tyr Phe Asp Thr  His Gln Gly 
    2345                 2350                 2355             


Leu Lys  Phe Met Gln Asp Leu  Phe Asn Ala Leu Leu  Arg Glu Thr 
    2360                 2365                 2370             


Ser Met  Lys Asn Lys Thr Glu  Asn Asn Ile Asp Phe  Phe Thr Val 
    2375                 2380                 2385             


Val Ser  Gln Leu Phe Phe His  Val Asn Lys Ser Glu  Asp Leu Phe 
    2390                 2395                 2400             


Lys Leu  Asn Gln Asp Leu Gly  Ser Ala Leu His Leu  Val Arg Glu 
    2405                 2410                 2415             


Cys Ser  Thr Glu Met Ala Arg  Leu Leu Asp Thr Ile  Leu His Ser 
    2420                 2425                 2430             


Pro Asn  Lys Asp Phe Tyr Ala  Leu Tyr Pro Thr Leu  Gln Glu Val 
    2435                 2440                 2445             


Ile Leu  Ala Asn Leu Thr Asp  Leu Leu Phe Phe Ile  Asn Asn Ser 
    2450                 2455                 2460             


Phe Pro  Leu Arg Asn Arg Ala  Thr Leu Glu Ile Thr  Lys Arg Leu 
    2465                 2470                 2475             


Val Gly  Ala Ile Ser Arg Ala  Ser Glu Glu Ser His  Val Leu Lys 
    2480                 2485                 2490             


Pro Leu  Leu Glu Met Ser Gly  Thr Leu Val Met Leu  Leu Asn Asp 
    2495                 2500                 2505             


Ser Ala  Asp Leu Arg Asp Leu  Ala Thr Ser Met Asp  Ser Ile Val 
    2510                 2515                 2520             


Lys Leu  Leu Lys Leu Val Lys  Lys Val Ser Gly Lys  Met Ser Thr 
    2525                 2530                 2535             


Val Phe  Lys Thr His Phe Ile  Ser Asn Thr Lys Asp  Ser Val Lys 
    2540                 2545                 2550             


Phe Phe  Asp Thr Leu Tyr Ser  Ile Met Gln Gln Ser  Val Gln Asn 
    2555                 2560                 2565             


Leu Val  Lys Glu Ile Ala Thr  Leu Lys Lys Ile Asp  His Phe Thr 
    2570                 2575                 2580             


Phe Glu  Lys Ile Asn Asp Leu  Leu Val Pro Phe Leu  Asp Leu Ala 
    2585                 2590                 2595             


Phe Glu  Met Ile Gly Val Glu  Pro Tyr Ile Ser Ser  Asn Ser Asp 
    2600                 2605                 2610             


Ile Phe  Ser Met Ser Pro Ser  Ile Leu Ser Tyr Met  Asn Gln Ser 
    2615                 2620                 2625             


Lys Asp  Phe Ser Asp Ile Leu  Glu Glu Ile Ala Glu  Phe Leu Thr 
    2630                 2635                 2640             


Ser Val  Lys Met Asn Leu Glu  Asp Met Arg Ser Leu  Ala Val Ala 
    2645                 2650                 2655             


Phe Asn  Asn Glu Thr Gln Thr  Phe Ser Met Asp Ser  Val Asn Leu 
    2660                 2665                 2670             


Xaa Glu  Glu Ile Leu Gly Cys  Leu Val Pro Ile Asn  Asn Ile Thr 
    2675                 2680                 2685             


Asn Gln  Met Asp Phe Leu Tyr  Pro Asn Pro Ile Ser  Thr His Ser 
    2690                 2695                 2700             


Gly Pro  Gln Asp Ile Lys Trp  Glu Ile Ile His Glu  Val Ile Leu 
    2705                 2710                 2715             


Phe Leu  Asp Lys Ile Leu Ser  Gln Asn Ser Thr Glu  Ile Gly Ser 
    2720                 2725                 2730             


Phe Leu  Lys Met Val Ile Cys  Leu Thr Leu Glu Ala  Leu Trp Lys 
    2735                 2740                 2745             


Asn Leu  Lys Lys Asp Asn Trp  Asn Val Ser Asn Val  Leu Met Thr 
    2750                 2755                 2760             


Phe Thr  Gln His Pro Asn Asn  Leu Leu Lys Thr Ile  Glu Thr Val 
    2765                 2770                 2775             


Leu Glu  Ala Ser Ser Gly Ile  Lys Ser Asp Tyr Glu  Gly Asp Leu 
    2780                 2785                 2790             


Asn Lys  Ser Leu Tyr Phe Asp  Thr Pro Leu Ser Gln  Asn Ile Thr 
    2795                 2800                 2805             


His His  Gln Leu Glu Lys Ala  Ile His Asn Val Leu  Ser Arg Ile 
    2810                 2815                 2820             


Ala Leu  Trp Arg Lys Gly Leu  Arg Phe Asn Asn Ser  Glu Trp Ile 
    2825                 2830                 2835             


Thr Ser  Thr Arg Thr Leu Phe  Gln Pro Leu Phe Glu  Ile Phe Ile 
    2840                 2845                 2850             


Lys Ala  Thr Thr Gly Lys Asn  Val Thr Ser Glu Lys  Glu Glu Arg 
    2855                 2860                 2865             


Thr Glu  Lys Glu Met Ile Asp  Phe Pro Tyr Ser Phe  Lys Pro Phe 
    2870                 2875                 2880             


Phe Cys  Leu Glu Lys Tyr Leu  Gly Gly Leu Phe Val  Leu Thr Lys 
    2885                 2890                 2895             


Tyr Trp  Gln Gln Ile Pro Leu  Thr Asp Gln Ser Val  Val Glu Ile 
    2900                 2905                 2910             


Cys Glu  Val Phe Gln Gln Thr  Val Lys Pro Ser Glu  Ala Met Glu 
    2915                 2920                 2925             


Met Leu  Gln Lys Val Lys Met  Met Val Val Arg Val  Leu Thr Ile 
    2930                 2935                 2940             


Val Ala  Glu Asn Pro Ser Trp  Thr Lys Asp Ile Leu  Cys Ala Thr 
    2945                 2950                 2955             


Leu Ser  Cys Lys Gln Asn Gly  Ile Arg His Leu Ile  Leu Ser Ala 
    2960                 2965                 2970             


Ile Gln  Gly Val Thr Leu Ala  Gln Asp His Phe Gln  Glu Ile Glu 
    2975                 2980                 2985             


Lys Ile  Trp Ser Ser Pro Asn  Gln Leu Asn Cys Glu  Ser Leu Ser 
    2990                 2995                 3000             


Lys Asn  Leu Ser Ser Thr Leu  Glu Ser Phe Lys Ser  Ser Leu Glu 
    3005                 3010                 3015             


Asn Ala  Thr Gly Gln Asp Cys  Thr Ser Gln Pro Arg  Leu Glu Thr 
    3020                 3025                 3030             


Val Gln  Gln His Leu Tyr Met  Leu Ala Lys Ser Leu  Glu Glu Thr 
    3035                 3040                 3045             


Trp Ser  Ser Gly Asn Pro Ile  Met Thr Phe Leu Ser  Asn Phe Thr 
    3050                 3055                 3060             


Val Thr  Glu Asp Val Lys Ile  Lys Asp Leu Met Lys  Asn Ile Thr 
    3065                 3070                 3075             


Lys Leu  Thr Glu Glu Leu Arg  Ser Ser Ile Gln Ile  Ser Asn Glu 
    3080                 3085                 3090             


Thr Ile  His Ser Ile Leu Glu  Ala Asn Ile Ser His  Ser Lys Val 
    3095                 3100                 3105             


Leu Phe  Ser Ala Leu Thr Val  Ala Leu Ser Gly Lys  Cys Asp Gln 
    3110                 3115                 3120             


Glu Ile  Leu His Leu Leu Leu  Thr Phe Pro Lys Gly  Glu Lys Ser 
    3125                 3130                 3135             


Trp Ile  Ala Ala Glu Glu Leu  Cys Ser Leu Pro Gly  Ser Lys Val 
    3140                 3145                 3150             


Tyr Ser  Leu Ile Val Leu Leu  Ser Arg Asn Leu Asp  Val Arg Ala 
    3155                 3160                 3165             


Phe Ile  Tyr Lys Thr Leu Met  Pro Ser Glu Ala Asn  Gly Leu Leu 
    3170                 3175                 3180             


Asn Ser  Leu Leu Asp Ile Val  Ser Ser Leu Ser Ala  Leu Leu Ala 
    3185                 3190                 3195             


Lys Ala  Gln His Val Phe Glu  Tyr Leu Pro Glu Phe  Leu His Thr 
    3200                 3205                 3210             


Phe Lys  Ile Thr Ala Leu Leu  Glu Thr Leu Asp Phe  Gln Gln Val 
    3215                 3220                 3225             


Ser Gln  Asn Val Gln Ala Arg  Ser Ser Ala Phe Gly  Ser Phe Gln 
    3230                 3235                 3240             


Phe Val  Met Lys Met Val Cys  Lys Asp Gln Ala Ser  Phe Leu Ser 
    3245                 3250                 3255             


Asp Ser  Asn Met Phe Ile Asn  Leu Pro Arg Val Lys  Glu Leu Leu 
    3260                 3265                 3270             


Glu Asp  Asp Lys Glu Lys Phe  Asn Ile Pro Glu Asp  Ser Thr Pro 
    3275                 3280                 3285             


Phe Cys  Leu Lys Leu Tyr Gln  Glu Ile Leu Gln Leu  Pro Asn Gly 
    3290                 3295                 3300             


Ala Leu  Val Trp Thr Phe Leu  Lys Pro Ile Leu His  Gly Lys Ile 
    3305                 3310                 3315             


Leu Tyr  Thr Pro Asn Thr Pro  Glu Ile Asn Lys Val  Ile Gln Lys 
    3320                 3325                 3330             


Ala Asn  Tyr Thr Phe Tyr Ile  Val Asp Lys Leu Lys  Thr Leu Ser 
    3335                 3340                 3345             


Glu Thr  Leu Leu Glu Met Ser  Ser Leu Phe Gln Arg  Ser Gly Ser 
    3350                 3355                 3360             


Gly Gln  Met Phe Asn Gln Leu  Gln Glu Ala Leu Arg  Asn Lys Phe 
    3365                 3370                 3375             


Val Arg  Asn Phe Val Glu Asn  Gln Leu His Ile Asp  Val Asp Lys 
    3380                 3385                 3390             


Leu Thr  Glu Lys Leu Gln Thr  Tyr Gly Gly Leu Leu  Asp Glu Met 
    3395                 3400                 3405             


Phe Asn  His Ala Gly Ala Gly  Arg Phe Arg Phe Leu  Gly Ser Ile 
    3410                 3415                 3420             


Leu Val  Asn Leu Ser Ser Cys  Val Ala Leu Asn Arg  Phe Gln Ala 
    3425                 3430                 3435             


Leu Gln  Ser Val Asp Ile Leu  Glu Thr Lys Ala His  Glu Leu Leu 
    3440                 3445                 3450             


Gln Gln  Asn Ser Phe Leu Ala  Ser Ile Ile Phe Ser  Asn Ser Leu 
    3455                 3460                 3465             


Phe Asp  Lys Asn Phe Arg Ser  Glu Ser Val Lys Leu  Pro Pro His 
    3470                 3475                 3480             


Val Ser  Tyr Thr Ile Arg Thr  Asn Val Leu Tyr Ser  Val Arg Thr 
    3485                 3490                 3495             


Asp Val  Val Lys Asn Pro Ser  Trp Lys Phe His Pro  Gln Asn Leu 
    3500                 3505                 3510             


Pro Ala  Asp Gly Phe Lys Tyr  Asn Tyr Val Phe Ala  Pro Leu Gln 
    3515                 3520                 3525             


Asp Met  Ile Glu Arg Ala Ile  Ile Leu Val Gln Thr  Gly Gln Glu 
    3530                 3535                 3540             


Ala Leu  Glu Pro Ala Ala Gln  Thr Gln Ala Ala Pro  Tyr Pro Cys 
    3545                 3550                 3555             


His Thr  Ser Asp Leu Phe Leu  Asn Asn Val Gly Phe  Phe Phe Pro 
    3560                 3565                 3570             


Leu Ile  Met Met Leu Thr Trp  Met Val Ser Val Ala  Ser Met Val 
    3575                 3580                 3585             


Arg Lys  Leu Val Tyr Glu Gln  Glu Ile Gln Ile Glu  Glu Tyr Met 
    3590                 3595                 3600             


Arg Met  Met Gly Val His Pro  Val Ile His Phe Leu  Ala Trp Phe 
    3605                 3610                 3615             


Leu Glu  Asn Met Ala Val Leu  Thr Ile Ser Ser Ala  Thr Leu Ala 
    3620                 3625                 3630             


Ile Val  Leu Lys Thr Ser Gly  Ile Phe Ala His Ser  Asn Thr Phe 
    3635                 3640                 3645             


Ile Val  Phe Leu Phe Leu Leu  Asp Phe Gly Met Ser  Val Val Met 
    3650                 3655                 3660             


Leu Ser  Tyr Leu Leu Ser Ala  Phe Phe Ser Gln Ala  Asn Thr Ala 
    3665                 3670                 3675             


Ala Leu  Cys Thr Ser Leu Val  Tyr Met Ile Ser Phe  Leu Pro Tyr 
    3680                 3685                 3690             


Ile Val  Leu Leu Val Leu His  Asn Gln Leu Ser Phe  Val Asn Gln 
    3695                 3700                 3705             


Thr Phe  Leu Cys Leu Leu Ser  Thr Thr Ala Phe Gly  Gln Gly Val 
    3710                 3715                 3720             


Phe Phe  Ile Thr Phe Leu Glu  Gly Gln Glu Thr Gly  Ile Gln Trp 
    3725                 3730                 3735             


Asn Asn  Met Tyr Gln Ala Leu  Glu Gln Gly Gly Met  Thr Phe Gly 
    3740                 3745                 3750             


Trp Val  Cys Trp Met Ile Leu  Phe Asp Ser Ser Leu  Tyr Phe Leu 
    3755                 3760                 3765             


Cys Gly  Trp Tyr Leu Ser Asn  Leu Ile Pro Gly Thr  Phe Gly Leu 
    3770                 3775                 3780             


Arg Lys  Pro Trp Tyr Phe Pro  Phe Thr Ala Ser Tyr  Trp Lys Ser 
    3785                 3790                 3795             


Val Gly  Phe Leu Val Glu Lys  Arg Gln Tyr Phe Leu  Ser Ser Ser 
    3800                 3805                 3810             


Leu Phe  Phe Phe Asn Glu Asn  Phe Asp Asn Lys Gly  Ser Ser Leu 
    3815                 3820                 3825             


Gln Asn  Arg Glu Gly Glu Leu  Glu Gly Ser Ala Pro  Gly Val Thr 
    3830                 3835                 3840             


Leu Val  Ser Val Thr Lys Glu  Tyr Glu Gly His Lys  Ala Val Val 
    3845                 3850                 3855             


Gln Asp  Leu Ser Leu Thr Phe  Tyr Arg Asp Gln Ile  Thr Ala Leu 
    3860                 3865                 3870             


Leu Gly  Thr Asn Gly Ala Gly  Lys Thr Thr Ile Ile  Ser Met Leu 
    3875                 3880                 3885             


Thr Gly  Leu His Pro Pro Thr  Ser Gly Thr Ile Ile  Ile Asn Gly 
    3890                 3895                 3900             


Lys Asn  Leu Gln Thr Asp Leu  Ser Arg Val Arg Met  Glu Leu Gly 
    3905                 3910                 3915             


Val Cys  Pro Gln Gln Asp Ile  Leu Leu Asp Asn Leu  Thr Val Arg 
    3920                 3925                 3930             


Glu His  Leu Leu Leu Phe Ala  Ser Ile Lys Ala Pro  Gln Trp Thr 
    3935                 3940                 3945             


Lys Lys  Glu Leu His Gln Gln  Val Asn Gln Thr Leu  Gln Asp Val 
    3950                 3955                 3960             


Asp Leu  Thr Gln His Gln His  Lys Gln Thr Arg Ala  Leu Ser Gly 
    3965                 3970                 3975             


Gly Leu  Lys Arg Lys Leu Ser  Leu Gly Ile Ala Phe  Met Gly Met 
    3980                 3985                 3990             


Ser Arg  Thr Val Val Leu Asp  Glu Pro Thr Ser Gly  Val Asp Pro 
    3995                 4000                 4005             


Cys Ser  Arg His Ser Leu Trp  Asp Ile Leu Leu Lys  Tyr Arg Glu 
    4010                 4015                 4020             


Gly Arg  Thr Ile Ile Phe Thr  Thr His His Leu Asp  Glu Ala Glu 
    4025                 4030                 4035             


Ala Leu  Ser Asp Arg Val Ala  Val Leu Gln His Gly  Arg Leu Arg 
    4040                 4045                 4050             


Cys Cys  Gly Pro Pro Phe Cys  Leu Lys Glu Ala Tyr  Gly Gln Gly 
    4055                 4060                 4065             


Leu Arg  Leu Thr Leu Thr Arg  Gln Pro Ser Val Leu  Glu Ala His 
    4070                 4075                 4080             


Asp Leu  Lys Asp Met Ala Cys  Val Thr Ser Leu Ile  Lys Ile Tyr 
    4085                 4090                 4095             


Ile Pro  Gln Ala Phe Leu Lys  Asp Ser Ser Gly Ser  Glu Leu Thr 
    4100                 4105                 4110             


Tyr Thr  Ile Pro Lys Asp Thr  Asp Lys Ala Cys Leu  Lys Gly Leu 
    4115                 4120                 4125             


Phe Gln  Ala Leu Asp Glu Asn  Leu His Gln Leu His  Leu Thr Gly 
    4130                 4135                 4140             


Tyr Gly  Ile Ser Asp Thr Thr  Leu Glu Glu Val Phe  Leu Met Leu 
    4145                 4150                 4155             


Leu Gln  Asp Ser Asn Lys Lys  Ser His Ile Ala Leu  Gly Thr Glu 
    4160                 4165                 4170             


Ser Glu  Leu Gln Asn His Arg  Pro Thr Gly His Leu  Ser Gly Tyr 
    4175                 4180                 4185             


Cys Gly  Ser Leu Ala Arg Pro  Ala Thr Val Gln Gly  Val Gln Leu 
    4190                 4195                 4200             


Leu Arg  Ala Gln Val Ala Ala  Ile Leu Ala Arg Arg  Leu Arg Arg 
    4205                 4210                 4215             


Thr Leu  Arg Ala Gly Lys Ser  Thr Leu Ala Asp Leu  Leu Leu Pro 
    4220                 4225                 4230             


Val Leu  Phe Val Ala Leu Ala  Met Gly Leu Phe Met  Val Arg Pro 
    4235                 4240                 4245             


Leu Ala  Thr Glu Tyr Pro Pro  Leu Arg Leu Thr Pro  Gly His Tyr 
    4250                 4255                 4260             


Gln Arg  Ala Glu Thr Tyr Phe  Phe Ser Ser Gly Gly  Asp Asn Leu 
    4265                 4270                 4275             


Asp Leu  Thr Arg Val Leu Leu  Arg Lys Phe Arg Asp  Gln Asp Leu 
    4280                 4285                 4290             


Pro Cys  Ala Asp Leu Asn Pro  Arg Gln Lys Asn Ser  Ser Cys Trp 
    4295                 4300                 4305             


Arg Thr  Asp Pro Phe Ser His  Pro Glu Phe Gln Asp  Ser Cys Gly 
    4310                 4315                 4320             


Cys Leu  Lys Cys Pro Asn Arg  Ser Ala Ser Ala Pro  Tyr Leu Thr 
    4325                 4330                 4335             


Asn His  Leu Gly His Thr Leu  Leu Asn Leu Ser Gly  Phe Asn Met 
    4340                 4345                 4350             


Glu Glu  Tyr Leu Leu Ala Pro  Ser Glu Lys Pro Arg  Leu Gly Gly 
    4355                 4360                 4365             


Trp Ser  Phe Gly Leu Lys Ile  Pro Ser Glu Ala Gly  Gly Ala Asn 
    4370                 4375                 4380             


Gly Asn  Ile Ser Lys Pro Pro  Thr Leu Ala Lys Val  Trp Tyr Asn 
    4385                 4390                 4395             


Gln Lys  Gly Phe His Ser Leu  Pro Ser Tyr Leu Asn  His Leu Asn 
    4400                 4405                 4410             


Asn Leu  Ile Leu Trp Gln His  Leu Pro Pro Thr Val  Asp Trp Arg 
    4415                 4420                 4425             


Gln Tyr  Gly Ile Thr Leu Tyr  Ser His Pro Tyr Gly  Gly Ala Leu 
    4430                 4435                 4440             


Leu Asn  Glu Asp Lys Ile Leu  Glu Ser Ile Arg Gln  Cys Gly Val 
    4445                 4450                 4455             


Ala Leu  Cys Ile Val Leu Gly  Phe Ser Ile Leu Ser  Ala Ser Ile 
    4460                 4465                 4470             


Gly Ser  Ser Val Val Arg Asp  Arg Val Ile Gly Ala  Lys Arg Leu 
    4475                 4480                 4485             


Gln His  Ile Ser Gly Leu Gly  Tyr Arg Met Tyr Trp  Phe Thr Asn 
    4490                 4495                 4500             


Phe Leu  Tyr Asp Met Leu Phe  Tyr Leu Val Ser Val  Cys Leu Cys 
    4505                 4510                 4515             


Val Ala  Val Ile Val Ala Phe  Gln Leu Thr Ala Phe  Thr Phe Arg 
    4520                 4525                 4530             


Lys Asn  Leu Ala Ala Thr Ala  Leu Leu Leu Ser Leu  Phe Gly Tyr 
    4535                 4540                 4545             


Ala Thr  Leu Pro Trp Met Tyr  Leu Met Ser Arg Ile  Phe Ser Ser 
    4550                 4555                 4560             


Ser Asp  Val Ala Phe Ile Ser  Tyr Val Ser Leu Asn  Phe Ile Phe 
    4565                 4570                 4575             


Gly Leu  Cys Thr Met Pro Ile  Thr Ile Met Pro Arg  Leu Leu Ala 
    4580                 4585                 4590             


Ile Ile  Ser Lys Ala Lys Asn  Leu Gln Asn Ile Tyr  Asp Val Leu 
    4595                 4600                 4605             


Lys Trp  Val Phe Thr Ile Phe  Pro Gln Phe Cys Leu  Gly Gln Gly 
    4610                 4615                 4620             


Leu Val  Glu Leu Cys Tyr Asn  Gln Ile Lys Tyr Asp  Leu Thr His 
    4625                 4630                 4635             


Asn Phe  Gly Ile Asp Ser Tyr  Val Ser Pro Phe Glu  Met Asn Phe 
    4640                 4645                 4650             


Leu Gly  Trp Ile Phe Val Gln  Leu Ala Ser Gln Gly  Thr Val Leu 
    4655                 4660                 4665             


Leu Leu  Leu Arg Val Leu Leu  His Trp Asp Leu Leu  Arg Trp Pro 
    4670                 4675                 4680             


Arg Gly  His Ser Thr Leu Gln  Gly Thr Val Lys Ser  Ser Lys Asp 
    4685                 4690                 4695             


Thr Asp  Val Glu Lys Glu Glu  Lys Arg Val Phe Glu  Gly Arg Thr 
    4700                 4705                 4710             


Asn Gly  Asp Ile Leu Val Leu  Tyr Asn Leu Ser Lys  His Tyr Arg 
    4715                 4720                 4725             


Arg Phe  Phe Gln Asn Ile Ile  Ala Val Gln Asp Ile  Ser Leu Gly 
    4730                 4735                 4740             


Ile Pro  Lys Gly Glu Cys Phe  Gly Leu Leu Gly Val  Asn Gly Ala 
    4745                 4750                 4755             


Gly Lys  Ser Thr Thr Phe Lys  Met Leu Asn Gly Glu  Val Ser Leu 
    4760                 4765                 4770             


Thr Ser  Gly His Ala Ile Ile  Arg Thr Pro Met Gly  Asp Ala Val 
    4775                 4780                 4785             


Asp Leu  Ser Ser Ala Gly Thr  Ala Gly Val Leu Ile  Gly Tyr Cys 
    4790                 4795                 4800             


Pro Gln  Gln Asp Ala Leu Asp  Glu Leu Leu Thr Gly  Trp Glu His 
    4805                 4810                 4815             


Leu Tyr  Tyr Tyr Cys Ser Leu  Arg Gly Ile Pro Arg  Gln Cys Ile 
    4820                 4825                 4830             


Pro Glu  Val Ala Gly Asp Leu  Ile Arg Arg Leu His  Leu Glu Ala 
    4835                 4840                 4845             


His Ala  Asp Lys Pro Val Ala  Thr Tyr Ser Gly Gly  Thr Lys Arg 
    4850                 4855                 4860             


Lys Leu  Ser Thr Ala Leu Ala  Leu Val Gly Lys Pro  Asp Ile Leu 
    4865                 4870                 4875             


Leu Leu  Asp Glu Pro Ser Ser  Gly Met Asp Pro Cys  Ser Lys Arg 
    4880                 4885                 4890             


Tyr Leu  Trp Gln Thr Ile Met  Lys Glu Val Arg Glu  Gly Cys Ala 
    4895                 4900                 4905             


Ala Val  Leu Thr Ser His Ser  Met Glu Glu Cys Glu  Ala Leu Cys 
    4910                 4915                 4920             


Thr Arg  Leu Ala Ile Met Val  Asn Gly Ser Phe Lys  Cys Leu Gly 
    4925                 4930                 4935             


Ser Pro  Gln His Ile Lys Asn  Arg Phe Gly Asp Gly  Tyr Thr Val 
    4940                 4945                 4950             


Lys Val  Trp Leu Cys Lys Glu  Ala Asn Gln His Cys  Thr Val Ser 
    4955                 4960                 4965             


Asp His  Leu Lys Leu Tyr Phe  Pro Gly Ile Gln Phe  Lys Gly Gln 
    4970                 4975                 4980             


His Leu  Asn Leu Leu Glu Tyr  His Val Pro Lys Arg  Trp Gly Cys 
    4985                 4990                 4995             


Leu Ala  Asp Leu Phe Lys Val  Ile Glu Asn Asn Lys  Thr Phe Leu 
    5000                 5005                 5010             


Asn Ile  Lys His Tyr Ser Ile  Asn Gln Thr Thr Leu  Glu Gln Val 
    5015                 5020                 5025             


Phe Ile  Asn Phe Ala Ser Glu  Gln Gln Gln Thr Leu  Gln Ser Thr 
    5030                 5035                 5040             


Leu Asp  Pro Ser Thr Asp Ser  His His Thr His His  Leu Pro Ile 
    5045                 5050                 5055             


<210> 52
<211> 17209
<212> DNA
<213> Homo sapiens

<400> 52
ggactgagag cagggagcag caggcatggg gcatgccggg tgccagttca aagccctgct       60

gtggaagaat tggctctgca gactcaggaa cccggtcctt ttccttgctg aattcttctg      120

gccttgtatc ctgtttgtaa ttctgacagt tcttcgtttt caagaacctc ccagatacag      180

agacatttgt tatttgcagc cccgagatct acccagctgt ggtgttatcc cctttgttca      240

aagccttctt tgtaacactg gatcaaggtg taggaacttc agctatgaag ggtcaatgga      300

gcatcatttt cgtttgtcta ggttccaaac tgcagctgac cccaagaaag tcaacaacct      360

ggccttttta aaagagatac aagacctggc agaggaaatt catggaatga tggacaaggc      420

aaaaaactta aaaagacttt gggtagaacg atccaacact ccagattctt cttatggttc      480

cagttttttt acaatggatc tcaataagac cgaggaggta atattgaaac tggaaagcct      540

ccatcagcag cctcatatct gggattttct acttttactg ccgagactac acacaagcca      600

tgatcatgtg gaagatggca tggatgttgc agtgaacctt ctccagacca ttttgaattc      660

cttaatatcc ctagaagatt tagattggct tccactcaac caaacttttt cccaggtttc      720

tgaacttgta ctgaatgtga ccatttcgac actgacattt ctgcagcaac atggagtagc      780

agtcaccgag ccagtttacc acctgtccat gcagaatata gtgtgggatc cacagaaagt      840

ccagtatgat ctcaaatccc agtttggctt tgrtgatctt cacacggaac agatcctgaa      900

ctcttcagct gaactgaagg agattcccac agacacttcc ttggagaaga tggtgtgttc      960

agtcttgtct agcacatcag aggatgaagc tgagaaatgg ggccacgttg gaggctgcca     1020

ccctaagtgg tcagaagcca aaaactatct tgtccatgca gtcagctggc tgcgagtcta     1080

ccaacaggtg tttgttcagt ggcaacaggg tagcctgctt cagaagacac tcacaggcat     1140

gggccatagt ctggaggctc tcaggaatca gtttgaagaa gagagcaagc cctggaaggt     1200

ggtggaagct ctgcacactg cactgctcct gctgaatgac agcttgtcag cagatggccc     1260

aaaagataat catacatttc caaagatatt acagcatctg tggaaattgc aaagcttgct     1320

gcaaaacctg ccccagtggc cggcactgaa gagatttctt cagcttgatg gagctctcag     1380

aaatgcgata gctcagaatt tacattttgt ccaagaagtc ctcatttgcc tggagacatc     1440

agctaatgat tttaaatggt ttgaacttaa ccaattgaaa ctggaaaagg atgtgttctt     1500

ttgggagctg aaacagatgt tggcgaagaa tgctgtctgc ccgaatggtc gtttctctga     1560

gaaggaggtc tttttgccgc ctggaaactc cagcatatgg ggtggtctcc agggactgtt     1620

gtgctattgt aactcctctg agacgagtgt tttaaacaag ctacttggtt cagtagagga     1680

tgctgatcgt attttgcaag aggtcattac ttggcacaaa aatatgtcag ttttaatacc     1740

tgaagaatat ttggactggc aggaacttga gatgcagctg tcagaagcaa gcctttcctg     1800

tactcggctc ttcctgctgc tgggagctga tccctctcct gagaatgatg tcttttctag     1860

tgactgtaag caccagcttg tctccacagt gatatttcat acacttgaaa aaacacaatt     1920

tttcctggaa caagcatatt attggaaagc cttcaaaaag tttatcagga agacttgcga     1980

agtggcccaa tatgtaaata tgcaagagag tttccagaac agactattgg cttttcctga     2040

ggaatctcct tgttttgaag aaaacatgga ttggaaaatg atcagtgata attattttca     2100

atttttgaat aacttactca agtctccaac agcttccata tccagggctt taaatttcac     2160

aaagcacctt ctaatgatgg aaaagaagtt gcacaccctt gaggatgaac aaatgaactt     2220

tcttttatca tttgtggaat tttttgagaa attattgttg cctaatcttt ttgactcctc     2280

cattgttccc agtttccaca gcctcccatc tctcacagag gatattctga atataagttc     2340

tctgtggaca aatcatttaa aaagtttaaa gagagaccca tctgccactg atgctcagaa     2400

actcttggaa tttggcaacg aagtgatttg gaaaatgcag actctcggaa gtcactggat     2460

aaggaaggaa ccaaaaaatc ttttgagatt catagaatta atactttttg aaattaatcc     2520

caaattacta gaattatggg cctatggcat ttcaaaagga aaaagagcta aattggaaaa     2580

cttctttaca cttttaaatt tttctgttcc agaaaatgag attctgagta caagttttaa     2640

cttttcccag ttgttccatt cagattggcc taaatcacca gctatgaaca tagattttgt     2700

acgtttaagt gaggctataa taactagtct ccatgaattt ggatttttgg agcaggaaca     2760

gatctcagaa gctctgaaca cagtctacgc tatcaggaat gcatctgatc ttttctcagc     2820

cctttctgaa ccacaaaaac aagaagttga taaaattttg actcacatac acctaaatgt     2880

cttccaggac aaggattcag ctttacttct gcaaatttat tcttcatttt accgatatat     2940

ttatgaatta ttgaatattc agagtagagg ctcttcgttg actttcctta cacaaatctc     3000

aaaacacatt ttggatatca taaaacaatt taatttccaa aacatcagta aagcatttgc     3060

atttttattt aagacagcag aggttcttgg gggaatttct aatgtatctt actgtcagca     3120

attgctttca atttttaact ttttggagct tcaggcccaa tccttcatgt ctacagaggg     3180

ccaagaactg gaagtgatcc acactacttt gacaggcctc aaacagctgc tcataattga     3240

tgaagatttt cgtatttctt tatttcaata tatgagccaa ttcttcaaca gttcagtaga     3300

agacctattg gataataaat gcttgatttc ggacaataaa cacatttctt ccgtaaatta     3360

ttcaacaagt gaggagtctt catttgtttt tccattggca caaatttttt caaacctctc     3420

agcaaatgtc agtgtgttca acaagtttat gtccattcac tgtaccgttt catggcttca     3480

aatgtggact gaaatctggg aaaccatatc tcaattattt aagtttgaca tgaatgtttt     3540

cacatctctt catcatggtt tcactcagct tttggatgaa ttggaagatg atgtgaaagt     3600

ctctaaaagc tgccagggta tacttcccac ccataatgtt gctagactca tattaaattt     3660

gtttaaaaat gtaactcaag ccaatgactt ccataattgg gaggacttcc tggatctcag     3720

ggattttttg gtagctttag gtaatgcatt agtttcagta aaaaaactta acttggagca     3780

agtggagaaa tcccttttca ccatggaagc tgccctgcat cagttgaaga catttccatt     3840

caacgaaagt acaagcagag agtttttaaa ttctctgctt gaagttttca ttgagtttag     3900

cagtacctca gaatatatag tcagaaatct agattcaata aatgactttc tttcaaataa     3960

tctcacaaat tatggagaaa aatttgaaaa tatcatcact gagctaagag aagcaatagt     4020

atttcttaga aatgtatcac atgatcgaga tttgttttcc tgtgctgata ttttccaaaa     4080

tgttactgag tgtattttag aagatggctt tttatatgta aatacctcac agaggatgtt     4140

acgtattcta gacacgttaa attccacatt ttcctctgag aacacaatta gcagtctgaa     4200

aggatgcatt gtatggttag atgtcataaa ccatttgtat ttgttgtcta actccagttt     4260

ttcacaaggt cgtcttcaaa atattttggg gaatttcaga gatatagaaa acaaaatgaa     4320

ctctatatta aaaattgtaa cttgggtgtt aaatataaaa aaacctcttt gttcatcaaa     4380

tggctcacat ataaattgtg tcaatattta cttgaaagat gtaactgact ttctaaatat     4440

tgtacttact acagtctttg aaaaagagaa gaaacctaaa tttgagattt tattagctct     4500

tttaaatgat tccacaaagc aagtaaggat gagtatcaac aacttaacaa cagactttga     4560

ttttgcatct cagtccaatt ggagatattt tactgaatta attctaagac caatagaaat     4620

gtcagatgaa attcctaatc agtttcaaaa tatttggctt catttaataa cactggggaa     4680

ggaatttcag aagcttgtaa aaggtattta ttttaacatc ctggaaaata attcctcttc     4740

taaaactgaa aacttgttaa acatatttgc caccagtcca aaagaaaagg atgtaaacag     4800

tgtaggcaat tccatttatc acttagctag ttaccttgcc ttcagcttat ctcatgacct     4860

ccaaaattca ccaaaaataa taatttcacc tgaaataatg aaagctacag gtcttggtat     4920

tcaactgata agggatgtgt tcaactcctt aatgcctgta gttcatcaca ctagtccaca     4980

aaatgcaggt tatatgcaag ctttgaagaa ggtaacttct gtcatgcgta cccttaagaa     5040

agcagacata gaccttttag tggatcagct tgaacaagtt agtgtaaacc taatggattt     5100

ctttaagaat atcagtagtg tgggaactgg caatttagtg gtcaatttgc ttgttggctt     5160

gatggaaaaa tttgcagaca gctcacattc ttggaatgtt aatcatctgc tgcagctctc     5220

acgcctgttt cctaaagatg ttgtggatgc tgtgatagat gtgtactatg tgcttcctca     5280

tgctgtaagg ctcctgcagg gagtacctgg taaaaacatc actgaaggcc tcaaggatgt     5340

ctacagcttc acactccttc atggcataac catttcaaat atcaccaagg aagacttcgc     5400

aattgtgata aaaattcttt tggatacaat tgaattagta tcagataagc cagatattat     5460

ttcagaggct ttagcttgtt ttcctgtggt ttggtgctgg aatcacacaa attctggatt     5520

tcggcagaat tcaaagatag acccctgcaa tgtccatggg ctcatgtctt cttcctttta     5580

tggcaaagtg gccagtatac ttgatcattt ccacctgtct ccccaaggtg aagattcacc     5640

atgttcaaat gaaagctccc gaatggaaat aactaggaaa gtggtctgca taattcatga     5700

attagtggac tggaattcta ttcttctgga gctctctgaa gtcttccatg ttaacatttc     5760

tcttgtgaaa actgtgcaga aattttggca taagatatta ccgtttgtcc caccttcaat     5820

aaatcaaact agggatagca tctctgaact ctgtcctagt ggttccataa agcaagttgc     5880

tttgcaaatc atagaaaaac ttaaaaatgt caactttaca aaagttacat caggtgaaaa     5940

tattcttgac aaactaagta gtttaaacaa gatccttaac attaatgaag acacagagac     6000

atctgttcaa aatattattt cctcaaattt ggaaaggaca gtacaattga tttctgaaga     6060

ctggagccta gaaaaaagta cgcataatct actctcttta ttcatgatgc tccagaatgc     6120

aaatgtcaca ggtagcagtt tagaagcatt atcaagtttt attgaaaaaa gtgaaacacc     6180

ttacaacttt gaagaactat ggcccaagtt tcaacaaatc atgaaagacc taacccaaga     6240

ttttagaatc agacacctgc tttctgaaat gaacaaagga atcaaaagta taaattcaat     6300

ggctcttcaa aagataactt tgcagtttgc ccatttcctg gaaatcctgg attcaccgtc     6360

attgaagaca ttagaaatta ttgaagattt tctattggtc acaaaaaact ggcttcagga     6420

atatgcaaat gaggattact ccagaatgat agaaacatta ttcattcctg tgaccaatga     6480

gagttcaact gaagatatag ctttgttagc caaagctatt gctacttttt ggggctcttt     6540

aaaaaatata tctagagcag gcaattttga tgttgccttt cttacccatc tgctaaatca     6600

agaacagctg actaatttct cagttgttca gctgcttttt gaaaacatcc taattaattt     6660

gatcaataac ttagctggga attctcagga agcagcttgg aacttaaatg atactgacct     6720

tcaaataatg aatttcatta accttatctt gaaccatatg cagtcagaaa ctagtaggaa     6780

aacagttctc tctctgagaa gcatagtaga tttcacagaa cagtttttga aaacattctt     6840

ctcccttttt ctaaaggaag attctgagaa caaaatatct cttctgctga aatatttcca     6900

caaagatgtt attgcagaga tgagttttgt cccaaaagat aaaattctag aaattctgaa     6960

actggatcaa tttcttaccc tgatgataca agacagattg atgaacattt tttcaagttt     7020

aaaggagact atatatcacc taatgaaaag ttcatttata ttagacaatg gagaatttta     7080

ttttgatact catcaaggac tgaagttcat gcaagattta tttaatgccc ttctcaggga     7140

aacttcaatg aaaaataaga ctgaaaataa tatagacttt ttcacagtgg tgagtcagtt     7200

gtttttccat gtgaataagt ctgaggacct cttcaaactc aatcaagatc ttgggtcagc     7260

tcttcacctt gtaagagaat gttcaacaga gatggcaaga cttctggata caattttaca     7320

ctctcctaat aaggacttct atgctttgta tcctaccctc caagaagtta tacttgctaa     7380

tctaacggat ttgcttttct ttataaataa ttcattccct ctaagaaaca gagcaacatt     7440

agaaattact aagagattag ttggtgctat ttcaagagca agtgaagaaa gtcacgtcct     7500

gaaacccctc ttagaaatgt ctgggactct ggtcatgctg ttgaatgaca gtgctgacct     7560

gagagatctt gccacatcaa tggactccat tgtgaaactt cttaagctgg tcaagaaagt     7620

ttcggggaag atgtccacag tttttaaaac tcattttatc tccaatacca aggacagtgt     7680

gaaattcttt gacactctgt attccatcat gcaacaaagt gttcaaaatc ttgtgaaaga     7740

aatagctact ttaaaaaaaa tagatcattt cacatttgaa aagataaatg atttgttggt     7800

gccatttctt gacttggcct ttgaaatgat tggggtagaa ccttatatat catcaaactc     7860

tgatattttc agtatgtcac ctagcatact ctcatatatg aaccaatcta aggacttttc     7920

tgatattttg gaagaaattg ctgaattttt aacatctgtg aaaatgaact tggaagatat     7980

gaggagtctt gcggtagcat ttaacaatga gactcaaaca ttttctatgg attctgtcaa     8040

cttaygggaa gaaattctgg gttgcttagt tcctataaat aacatcacca accaaatgga     8100

cttcttatac cctaatccaa tttccactca tagtggccct caagatataa aatgggaaat     8160

aattcatgaa gtgatccttt ttttggataa aatattatca caaaacagca cagaaatagg     8220

atctttcttg aaaatggtga tctgtctcac cttagaagct ctttggaaaa acttaaagaa     8280

agataattgg aatgtttcta atgtgttgat gacgtttact cagcatccaa ataacctttt     8340

gaaaaccata gaaacagttt tagaggcctc cagtggaatt aaaagtgact atgaaggtga     8400

tttgaataaa agtttatatt ttgacacacc tttgagtcag aatataactc atcatcaact     8460

tgaaaaagca atccataatg ttttaagtag aatagctctc tggaggaaag gacttcgttt     8520

taacaactct gaatggataa cttccacaag aactttgttt cagccacttt ttgagatttt     8580

cattaaagca accaccggaa agaatgtcac atcagaaaaa gaagagagaa ccgagaaaga     8640

gatgattgac tttccttata gtttcaaacc atttttctgt ttggagaaat acctgggagg     8700

attatttgta ttgactaaat actggcaaca aatcccacta acagatcaaa gtgttgttga     8760

gatttgtgaa gttttccagc agactgtgaa gccctcagaa gccatggaga tgctgcagaa     8820

agtgaagatg atggtcgtac gtgtgctcac catcgttgca gaaaaccctt cctggaccaa     8880

ggacattttg tgtgctactc tgagttgcaa gcaaaatggg ataaggcatc tcattttatc     8940

tgctatacaa ggggtcactt tggcgcagga ccacttccag gaaattgaaa agatatggtc     9000

ctcgccgaat cagctaaatt gtgaaagtct tagcaagaat ctttctagca ccttggagag     9060

cttcaagagc agcttggaaa atgccactgg ccaggactgc acaagccagc cgaggctgga     9120

gacggtgcag cagcacttgt acatgttggc caaaagcctc gaggaaactt ggtcatcagg     9180

gaatcccatc atgacttttc tcagcaattt cacagtaact gaggatgtaa aaataaaaga     9240

tttgatgaag aatatcacca agttgactga ggagcttcgc tcttccatcc aaatctcgaa     9300

tgagactatc catagcattc tagaagcaaa tatttcccac tccaaggttc tcttcagtgc     9360

cctcaccgta gctctgtctg gaaagtgtga tcaggaaatc cttcatctcc tgctgacatt     9420

tcccaaaggg gaaaaatctt ggatcgcagc ggaggaactc tgtagcctgc cagggtcaaa     9480

agtgtattct ctgattgtgt tgctgagtcg aaacttggat gtgcgagctt tcatttacaa     9540

gactctgatg ccttctgaag caaatggctt gctcaactcc ttgctggata tagtttccag     9600

cctcagcgcc ttgcttgcca aagcccagca cgtctttgag tatcttcctg agtttcttca     9660

cacatttaaa atcactgcct tgctagaaac cctggacttt caacaggttt cacaaaatgt     9720

ccaggccaga agttcagctt ttggttcttt ccagtttgtg atgaagatgg tttgcaagga     9780

ccaagcatca ttccttagcg attctaatat gtttattaat ttgcccagag ttaaggaact     9840

cttggaagat gacaaagaaa aattcaacat tcctgaagat tcaacaccgt tttgcttgaa     9900

gctttatcag gaaattctac aattgccaaa tggtgctttg gtgtggacct tcctaaaacc     9960

catattgcat ggaaaaatac tatacacacc aaacactcca gaaattaaca aggtcattca    10020

aaaggctaat tacacctttt atattgtgga caaactaaaa actttatcag aaacactgct    10080

ggaaatgtcc agccttttcc agagaagtgg aagtggccag atgttcaacc agctgcagga    10140

ggccctgaga aacaaatttg taagaaactt tgtagaaaac cagttgcaca ttgatgtaga    10200

caaacttact gaaaaactcc agacatacgg agggctgctg gatgagatgt ttaaccatgc    10260

aggcgctgga cgcttccgtt tcttgggcag catcttggtc aatctctctt cctgcgtggc    10320

actgaaccgt ttccaggctc tgcagtctgt cgacatcctg gagactaaag cacatgaact    10380

cttgcagcag aacagcttct tggccagtat cattttcagc aattccttat tcgacaagaa    10440

cttcagatca gagtctgtca aactgccacc ccatgtctca tacacaatcc ggaccaatgt    10500

gttatacagc gtgcgaacag atgtggtaaa aaacccttct tggaagttcc accctcagaa    10560

tctaccagct gatgggttca aatataacta cgtctttgcc ccactgcaag acatgatcga    10620

aagagccatc attttggtgc agactgggca ggaagccctg gaaccagcag cacagactca    10680

ggcggcccct tacccctgcc ataccagcga cctattcctg aacaacgttg gtttcttttt    10740

tccactgata atgatgctga cgtggatggt gtctgtggcc agcatggtca gaaagttggt    10800

gtatgagcag gagatacaga tagaagagta tatgcggatg atgggagtgc atccagtgat    10860

ccatttcctg gcctggttcc tggagaacat ggctgtgttg accataagca gtgctactct    10920

ggccatcgtt ctgaaaacaa gtggcatctt tgcacacagc aataccttta ttgttttcct    10980

ctttctcttg gattttggga tgtcagtcgt catgctgagc tacctcttga gtgcattttt    11040

cagccaagct aatacagcgg ccctttgtac cagcctggtg tacatgatca gctttctgcc    11100

ctacatagtt ctattggttc tacataacca attaagtttt gttaatcaga catttctgtg    11160

ccttctttcg acaaccgcct ttggacaagg ggtatttttt attacattcc tggaaggaca    11220

agagacaggg attcaatgga ataatatgta ccaggctctg gaacaagggg gcatgacatt    11280

tggctgggtt tgctggatga ttctttttga ttcaagcctt tattttttgt gtggatggta    11340

cttgagcaac ttgattcctg gaacatttgg tttacggaaa ccatggtatt tcccctttac    11400

tgcctcatat tggaagagtg tgggtttctt ggtggagaaa aggcaatact ttctaagttc    11460

tagtctgttc ttcttcaatg agaactttga caataaaggg tcatcactgc aaaacaggga    11520

aggagagctt gaaggaagtg ccccgggagt caccctggtg tctgtgacca aggaatatga    11580

gggccacaag gctgtggtcc aagacctcag cctgaccttc tacagagacc aaatcaccgc    11640

cctgctgggg acaaacggtg ccgggaaaac cactatcata tccatgttga cggggctcca    11700

ccctcccact tctggaacca tcatcatcaa tggcaagaac ctacagacag acctgtcgag    11760

ggtcagaatg gagcttggtg tgtgtccgca gcaggacatc ctgttggaca acctcaccgt    11820

ccgggaacat ttgctgctct ttgcttccat aaaggcgcct cagtggacca agaaggagct    11880

gcatcagcaa gtcaatcaaa ctcttcagga tgtggactta actcagcatc agcacaaaca    11940

gacccgagct ctgtctggag gcctgaagag gaagctctcc cttggcattg ctttcatggg    12000

catgtcgagg accgtggttc tggatgagcc caccagtggg gtggaccctt gctcccggca    12060

tagcctgtgg gacattctgc tcaagtaccg agaaggtcgt acgatcatct tcacaaccca    12120

ccacctggat gaagccgaag cgctgagtga ccgcgtggcc gtcctccagc atgggaggct    12180

caggtgctgc ggtcctccct tctgcctgaa ggaggcatat ggccaggggc tccgcctgac    12240

actcacgagg cagccttctg ttctggaggc ccatgatctg aaagacatgg cttgtgttac    12300

atccctgata aagatctata ttccacaagc atttctcaaa gacagcagtg gaagtgagct    12360

gacctacacc attccaaagg acacagacaa ggcctgcttg aaagggctct tccaggccct    12420

ggatgagaac ctgcatcagc tgcacctgac gggctatggg atctcagaca ccaccttaga    12480

agaggtgttt ttgatgcttt tgcaagattc caacaagaaa tctcacattg ccctggggac    12540

tgagtcagag ctgcagaacc acaggcctac aggacatctg tctggctact gtggctccct    12600

agcacggccc gcaactgtgc agggcgtcca gctgctccgc gcacaagtgg ccgcgatcct    12660

ggcccggagg ctccgccgca cgctgcgcgc cgggaagagc accctcgccg acctgctgct    12720

gccagtcctc ttcgtggcct tggccatggg cttgttcatg gtgagacccc tggccaccga    12780

gtaccctccc ctcagactca cacctggaca ttaccagcgg gccgagacct actttttcag    12840

cagtgggggc gacaacttgg acctcacccg tgtgcttctg cggaagttta gagatcaaga    12900

tttgccctgt gcagatttaa acccacgcca gaagaattct tcatgctggc gcacagatcc    12960

cttttctcac ccagaattcc aggattcatg tggctgcctg aagtgtccaa atagaagtgc    13020

tagtgctccc tacctgacca accacctggg ccacacactg ttgaatctct caggcttcaa    13080

tatggaggag tacttgctgg caccatctga aaaaccaagg cttggaggtt ggtcttttgg    13140

attaaaaatc cccagtgaag ctggaggtgc aaatggaaac atatcaaaac ccccaactct    13200

ggcaaaggtg tggtataatc agaagggttt tcattcccta ccttcctact taaatcatct    13260

aaacaacctt attttgtggc agcacctacc ccctactgtg gactggagac aatacggaat    13320

aacactctac agccacccat atggaggggc cttgctgaac gaggacaaga tcctggagag    13380

catccgtcag tgtggagtgg ccctctgcat cgtgctggga ttctccatcc tgtctgcatc    13440

catcggcagc tctgtggtga gggacagggt gattggagcc aaaaggttgc agcacataag    13500

tggccttggc tacaggatgt actggttcac aaacttccta tatgacatgc tcttttactt    13560

ggtttccgtc tgcctgtgtg ttgccgttat tgtcgccttc cagttaacag cttttacttt    13620

ccgcaagaac ttggcagcca cggccctcct gctgtcactt ttcggatatg caactcttcc    13680

atggatgtac ctgatgtcca gaatcttttc cagttcggac gtggctttca tttcctatgt    13740

ctcactaaac ttcatctttg gcctttgtac catgcccata accattatgc cccggttgct    13800

agccatcatc tccaaagcta agaatttaca gaatatctat gatgtcctca agtgggtctt    13860

tactattttt cctcaattct gtcttggtca aggactggta gaactctgct ataatcagat    13920

caaatatgac ctgacccaca acttcggcat tgattcctat gtgagtccct ttgagatgaa    13980

ctttctgggc tggatcttcg tgcaactggc ctcgcagggc acagtacttc tcctcttgag    14040

ggttctgcta cactgggacc ttctgcgatg gccaaggggt cattctactc tccaaggcac    14100

agtcaaatct tctaaggata cagatgttga aaaagaggaa aagagagtgt ttgaaggaag    14160

gaccaatgga gacattcttg tgttatacaa ccttagtaaa cattatcgac gctttttcca    14220

gaatattatt gctgtgcaag atattagttt gggcatacca aaaggagagt gctttggact    14280

tctaggggtg aatggagctg ggaagagcac gactttcaaa atgctgaatg gtgaagtttc    14340

tctaacttca ggacatgcta tcatcaggac tcccatggga gacgccgtgg acctgtcttc    14400

tgctggcacg gcaggcgtgc tcattggcta ctgtccccag caggatgccc tggacgagct    14460

tctgactggt tgggaacatc tctattatta ctgtagctta cgcgggattc caaggcagtg    14520

catccctgag gttgctggag acctcatcag gcgcttacac ctcgaagccc acgcggacaa    14580

acctgtggcc acctacagtg ggggaaccaa gcggaaactc tctacagccc tggccctggt    14640

ggggaaacct gacattcttt tattggatga gcccagctct gggatggatc cctgctctaa    14700

gcggtacctg tggcaaacaa taatgaagga ggttcgggaa ggctgtgctg cggtgctgac    14760

ctcccacagc atggaggagt gtgaggctct ttgcacaaga ctggccataa tggttaacgg    14820

cagcttcaaa tgtcttggtt ctcctcagca catcaaaaat aggtttggtg atggttatac    14880

agtcaaagtt tggctctgta aggaagcaaa tcaacattgc actgtttctg accacttgaa    14940

gctttatttt ccaggaattc agttcaaggg acagcacctg aatttattag aatatcatgt    15000

gccaaaaaga tggggatgcc tagctgactt gttcaaagtt atagagaaca ataaaacctt    15060

cttgaatatt aagcattatt ccattaacca aaccactttg gagcaggtat ttattaattt    15120

tgcttctgag cagcagcaaa ctctacaatc tactcttgat ccatccactg acagtcacca    15180

cacacatcac ttgcccatct gagcactaaa gaagtttcca taaggaataa aaccttgtct    15240

tccattacaa ttaacagtca aggataaaac aagcacgcgc acaatcaagg agctggaaca    15300

cactctccag gccgtcaaat tattctcttg ttcattttct attttgaatc tccttgttag    15360

ttaataacca ccaaatggaa aggtcattct ttctgcagac ttttggggag ctcctccaaa    15420

acatttgttc tctttaccat gccagatgga caccagcttc tttgtgacaa aggcatgaat    15480

gatttgacag tgtccaaact gagacattct ggagctggaa agcctgtcac actagagtgt    15540

gtgtgacatg tccactctaa acatgtcact tttctgttaa gaaaactgag ccccctcccc    15600

acaggttaaa aaactttagt aacttgtttg tatagaaaat agtaacaagg actattttct    15660

attgttgtca tctatttact agatacatgt ttttaatgat tttaatgtaa gcttttatta    15720

atactgatga cattatatgg tatgatatga aaaaatcacc aattttttac atataaaaga    15780

taccttttta aaaaaatagg ttttaagagc tcttttagta tacactttag caaaattaat    15840

taaattgaac tagttactct gtatcaatta cagtagttct accagaatct cccaggttat    15900

aatttatgag ggtagagaaa taaaatgtag atgcattttc tttttcttca tttggatgaa    15960

taattactgt tttttgttat tctaagtcag tgtttttcaa agcgtagtgg tccccatatt    16020

agctgcattg ccatcttctg ggagcttgca agaaatgtac attctcagga tccactccag    16080

acctattgaa tctcaaattc tggggcttaa acaagcacat tccaagttaa gaaccaatga    16140

cctaagggaa tgtctggtta cctcctagtt atacaagcaa aatctgcata gtatgtagtc    16200

ttttttattt atttattttt tttttttgag gcggagtctc gctctgtcac ccaggctgga    16260

gtgcagtggc gcgatgtcgg ctcactgcaa gctccgcctc ctgggttcac gccattctcc    16320

tgcctcagcc tccccagcag ctgggactac aggcacacat cgccacaccc ggctaatttt    16380

tagtattttt agtagagacg gggtttcacc gtgttagcca ggatggtctc tatctcctga    16440

ccttgtgatc cgcccccctc cacctcccaa agtgctggga ttacaggcgt gagccaccgt    16500

gtccggccgt agtttatttt aaaatatatt tttaaaagct ttgtaaaaat tatgtcattc    16560

tcagaattgt tgtcttcaaa gcattgtcag atgtagagtg ctcagatgtg gctcttaaag    16620

actatataca tctgaatttt tcatcctata gttagtaaga tgcataaaat caatccacta    16680

ctgaaatagt ttccagtcag acatttctga gttcagacat ttctcaacat tcttttaaca    16740

acatttttct gaatcctcaa tagaaaatca cattaatctt attttaaaat ttggcctttt    16800

tcaacactaa cgttgagtac cggtagcttt gtgatcaaag gcatatactt ccttatgaga    16860

tttctttact aaagcaagat ttcattaaat ctctatttcc taaatatcat tctatacaaa    16920

agatattttt taaacggtaa ggattaagac aatcactgat agctttgttg tgagcaattt    16980

tgattcccat gtatcacatg aattacactt ccttaaataa attacagttt atggctgtat    17040

gatttattct ctaattctaa catagtctag ttgtcaaaag gaaatatgta atctttttat    17100

gattgttgaa tcaataaata ccaatttgtg aaacatgaat gtgtttaaac tgcagtgaat    17160

aaatgagatg tgctttaatt taacccaaaa aaaaaaaaaa aaaaaaaaa                17209


<210> 53
<211> 931
<212> PRT
<213> Homo sapiens

<400> 53
Met Lys Ile Gln Lys Lys Leu Thr Gly Cys Ser Arg Leu Met Leu Leu 
1               5                   10                  15      


Cys Leu Ser Leu Glu Leu Leu Leu Glu Ala Gly Ala Gly Asn Ile His 
            20                  25                  30          


Tyr Ser Val Pro Glu Glu Thr Asp Lys Gly Ser Phe Val Gly Asn Ile 
        35                  40                  45              


Ala Lys Asp Leu Gly Leu Gln Pro Gln Glu Leu Ala Asp Gly Gly Val 
    50                  55                  60                  


Arg Ile Val Ser Arg Gly Arg Met Pro Leu Phe Ala Leu Asn Pro Arg 
65                  70                  75                  80  


Ser Gly Ser Leu Ile Thr Ala Arg Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Ala Gln Ser Met Pro Cys Leu Val Ser Phe Asn Ile Leu Val Glu Asp 
            100                 105                 110         


Lys Met Lys Leu Phe Pro Val Glu Val Glu Ile Ile Asp Ile Asn Asp 
        115                 120                 125             


Asn Thr Pro Gln Phe Gln Leu Glu Glu Leu Glu Phe Lys Met Asn Glu 
    130                 135                 140                 


Ile Thr Thr Pro Gly Thr Arg Val Ser Leu Pro Phe Gly Gln Asp Leu 
145                 150                 155                 160 


Asp Val Gly Met Asn Ser Leu Gln Ser Tyr Gln Leu Ser Ser Asn Pro 
                165                 170                 175     


His Phe Ser Leu Asp Val Gln Gln Gly Ala Asp Gly Pro Gln His Pro 
            180                 185                 190         


Glu Met Val Leu Gln Ser Pro Leu Asp Arg Glu Glu Glu Ala Val His 
        195                 200                 205             


His Leu Ile Leu Thr Ala Ser Asp Gly Gly Glu Pro Val Arg Ser Gly 
    210                 215                 220                 


Thr Leu Arg Ile Tyr Ile Gln Val Val Asp Ala Asn Asp Asn Pro Pro 
225                 230                 235                 240 


Ala Phe Thr Gln Ala Gln Tyr His Ile Asn Val Pro Glu Asn Val Pro 
                245                 250                 255     


Leu Gly Thr Gln Leu Leu Met Val Asn Ala Thr Asp Pro Asp Glu Gly 
            260                 265                 270         


Ala Asn Gly Glu Val Thr Tyr Ser Phe His Asn Val Asp His Arg Val 
        275                 280                 285             


Ala Gln Ile Phe Arg Leu Asp Ser Tyr Thr Gly Glu Ile Ser Asn Lys 
    290                 295                 300                 


Glu Pro Leu Asp Phe Glu Glu Tyr Lys Met Tyr Ser Met Glu Val Gln 
305                 310                 315                 320 


Ala Gln Asp Gly Ala Gly Leu Met Ala Lys Val Lys Val Leu Ile Lys 
                325                 330                 335     


Val Leu Asp Val Asn Asp Asn Ala Pro Glu Val Thr Ile Thr Ser Val 
            340                 345                 350         


Thr Thr Ala Val Pro Glu Asn Phe Pro Pro Gly Thr Ile Ile Ala Leu 
        355                 360                 365             


Ile Ser Val His Asp Gln Asp Ser Gly Asp Asn Gly Tyr Thr Thr Cys 
    370                 375                 380                 


Phe Ile Pro Gly Asn Leu Pro Phe Lys Leu Glu Lys Leu Val Asp Asn 
385                 390                 395                 400 


Tyr Tyr Arg Leu Val Thr Glu Arg Thr Leu Asp Arg Glu Leu Ile Ser 
                405                 410                 415     


Gly Tyr Asn Ile Thr Ile Thr Ala Ile Asp Gln Gly Thr Pro Ala Leu 
            420                 425                 430         


Ser Thr Glu Thr His Ile Ser Leu Leu Val Thr Asp Ile Asn Asp Asn 
        435                 440                 445             


Ser Pro Val Phe His Gln Asp Ser Tyr Ser Ala Tyr Ile Pro Glu Asn 
    450                 455                 460                 


Asn Pro Arg Gly Ala Ser Ile Phe Ser Val Arg Ala His Asp Leu Asp 
465                 470                 475                 480 


Ser Asn Glu Asn Ala Gln Ile Thr Tyr Ser Leu Ile Glu Asp Thr Ile 
                485                 490                 495     


Gln Gly Ala Pro Leu Ser Ala Tyr Leu Ser Ile Asn Ser Asp Thr Gly 
            500                 505                 510         


Val Leu Tyr Ala Leu Arg Ser Phe Asp Tyr Glu Gln Phe Arg Asp Met 
        515                 520                 525             


Gln Leu Lys Val Met Ala Arg Asp Ser Gly Asp Pro Pro Leu Ser Ser 
    530                 535                 540                 


Asn Val Ser Leu Ser Leu Phe Leu Leu Asp Gln Asn Asp Asn Ala Pro 
545                 550                 555                 560 


Glu Ile Leu Tyr Pro Ala Leu Pro Thr Asp Gly Ser Thr Gly Val Glu 
                565                 570                 575     


Leu Ala Pro Leu Ser Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val 
            580                 585                 590         


Ala Val Asp Arg Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Arg Leu 
        595                 600                 605             


Leu Lys Ala Ser Glu Pro Gly Leu Phe Ser Val Gly Leu His Thr Gly 
    610                 615                 620                 


Glu Val Arg Thr Ala Arg Ala Leu Leu Asp Arg Asp Ala Leu Lys Gln 
625                 630                 635                 640 


Ser Leu Val Val Ala Val Gln Asp His Gly Gln Pro Pro Leu Ser Ala 
                645                 650                 655     


Thr Val Thr Leu Thr Val Ala Val Ala Asp Arg Ile Ser Asp Ile Leu 
            660                 665                 670         


Ala Asp Leu Gly Ser Leu Glu Pro Ser Ala Lys Pro Asn Asp Ser Asp 
        675                 680                 685             


Leu Thr Leu Tyr Leu Val Val Ala Ala Ala Ala Val Ser Cys Val Phe 
    690                 695                 700                 


Leu Ala Phe Val Ile Val Leu Leu Ala His Arg Leu Arg Arg Trp His 
705                 710                 715                 720 


Lys Ser Arg Leu Leu Gln Ala Ser Gly Gly Gly Leu Ala Ser Met Pro 
                725                 730                 735     


Gly Ser His Phe Val Gly Val Asp Gly Val Arg Ala Phe Leu Gln Thr 
            740                 745                 750         


Tyr Ser His Glu Val Ser Leu Thr Ala Asp Ser Arg Lys Ser His Leu 
        755                 760                 765             


Ile Phe Pro Gln Pro Asn Tyr Ala Asp Thr Leu Ile Ser Gln Glu Ser 
    770                 775                 780                 


Cys Glu Lys Lys Gly Phe Leu Ser Ala Pro Gln Ser Leu Leu Glu Asp 
785                 790                 795                 800 


Lys Lys Glu Pro Phe Ser Gln Gln Ala Pro Pro Asn Thr Asp Trp Arg 
                805                 810                 815     


Phe Ser Gln Ala Gln Arg Pro Gly Thr Ser Gly Ser Gln Asn Gly Asp 
            820                 825                 830         


Asp Thr Gly Thr Trp Pro Asn Asn Gln Phe Asp Thr Glu Met Leu Gln 
        835                 840                 845             


Ala Met Ile Leu Ala Ser Ala Ser Glu Ala Ala Asp Gly Ser Ser Thr 
    850                 855                 860                 


Leu Gly Gly Gly Ala Gly Thr Met Gly Leu Ser Ala Arg Tyr Gly Pro 
865                 870                 875                 880 


Gln Phe Thr Leu Gln His Val Pro Asp Tyr Arg Gln Asn Val Tyr Ile 
                885                 890                 895     


Pro Gly Ser Asn Ala Thr Leu Thr Asn Ala Ala Gly Lys Arg Asp Gly 
            900                 905                 910         


Lys Ala Pro Ala Gly Gly Asn Gly Asn Lys Lys Lys Ser Gly Lys Lys 
        915                 920                 925             


Glu Lys Lys 
    930     


<210> 54
<211> 4602
<212> DNA
<213> Homo sapiens

<400> 54
atgaagattc agaaaaagct gactggctgc agcaggctga tgcttctgtg tctttctctg       60

gagctgctgt tggaagctgg ggctgggaat attcactact cagtgccgga agagacagac      120

aaaggttcct tcgtaggcaa catcgccaag gacctagggc tgcaacccca ggagctggca      180

gatggcggag tccgcatcgt ctccagaggt aggatgccgc ttttcgctct gaatcctaga      240

agtggcagct tgatcaccgc gcgcaggata gaccgggagg agctctgcgc tcagagcatg      300

ccgtgtctcg tgagttttaa tatccttgtt gaggataaaa tgaagctttt tcctgttgaa      360

gtagaaataa ttgatattaa tgacaacact ccccaattcc agttagagga actggagttt      420

aaaatgaatg aaataacgac tccaggtacc agagtctcat tgccttttgg gcaagacctt      480

gatgtgggta tgaactcact ccagagctac caactcagct ctaaccctca tttctccctg      540

gatgtgcaac agggagccga tgggcctcaa catccagaga tggtgctgca gagtccctta      600

gacagagaag aagaagctgt ccaccacctc atcctcacag cttctgatgg gggtgaacca      660

gtccgttcag ggaccctcag aatttacatt caggtggtgg atgcaaatga caatcctcca      720

gcatttactc aggcacaata ccatataaat gtccccgaaa acgtgccgct gggtactcag      780

ctgctcatgg taaatgccac tgaccctgat gagggagcca atggggaagt aacgtactcc      840

tttcacaatg tagaccacag agtggcccaa atatttcgtt tagattctta cacaggagaa      900

atatcaaata aagaaccact agatttcgaa gaatacaaaa tgtattcaat ggaagttcaa      960

gcccaggatg gtgcggggct catggctaaa gttaaggtac tgatcaaagt tttggatgta     1020

aatgataatg ccccagaagt gaccatcacc tctgtcacca ctgcagttcc agaaaacttt     1080

cctcctggga ccataattgc tcttatcagt gtgcatgacc aggactcagg agacaatggc     1140

tacaccacat gtttcattcc tggaaattta ccctttaaat tggaaaagtt agttgataat     1200

tattaccgtt tagtgactga aagaacactg gacagagaac ttatctctgg gtacaacatc     1260

acaataacag caatagacca aggaactcca gctctatcta ctgaaactca catttcacta     1320

ctagtgacag atatcaatga caactcccca gtcttccatc aggactccta ctctgcctac     1380

attcccgaaa acaaccccag aggagcctcc atcttctctg tgagggccca cgacttggac     1440

agcaatgaga atgcacaaat cacttactcc ctaatagagg acactatcca gggggcaccc     1500

ctatctgcct acctctccat caactccgac actggggtcc tgtatgcgct gcgatccttc     1560

gactatgagc agttccggga catgcaactg aaagtgatgg cgcgggacag tggggatccg     1620

cccctcagca gcaacgtgtc tctcagccta ttcctgctgg accagaacga caacgcgccc     1680

gagatcctgt accccgccct ccccacagat ggttctaccg gcgtggagct ggcgcccctc     1740

tccgcagagc ccggctacct ggtgaccaag gtggtggcgg tggacagaga ctcgggccag     1800

aacgcctggc tgtcctaccg cctgctcaag gccagcgagc cgggactctt ctcggtgggt     1860

ctgcacacgg gcgaggtgcg cacggcgcga gccctgctgg acagagacgc gctcaagcag     1920

agtctcgtgg tggccgtcca ggaccacggc cagcccccgc tctccgccac tgtcacgctc     1980

accgtggccg tggccgacag gatctccgac atcctggccg acctgggcag cctcgagccc     2040

tccgccaaac ccaacgattc ggacctcact ctgtacctgg tggtggcggc ggccgcggtc     2100

tcctgcgtct tcctggcctt cgtcatcgtg ctgctggcgc acaggctgcg gcgctggcac     2160

aagtcacgtc tgctacaggc ttcgggaggc ggcttagcga gcatgcccgg ttcgcacttt     2220

gtgggcgtgg acggggttcg ggctttcctg cagacctatt cccacgaggt ctccctcact     2280

gcggactcgc ggaagagcca cctgattttc ccccagccca actatgcgga cacactcatc     2340

agccaggaga gctgtgagaa aaagggtttt ctatcagcac cccagtcttt acttgaagac     2400

aaaaaggaac cattttctca gcaagccccg cccaacacgg actggcgttt ctctcaggcc     2460

cagagacccg gcaccagcgg ctcccaaaat ggcgatgaca ccggcacctg gcccaacaac     2520

cagtttgaca cagagatgct gcaagccatg atcttggcgt ccgccagtga agctgctgat     2580

gggagctcca ccctgggagg gggtgccggc accatgggat tgagcgcccg ctacggaccc     2640

cagttcaccc tgcagcacgt gcccgactac cgccagaatg tctacatccc aggcagcaat     2700

gccacactga ccaacgcagc tggcaagcgg gatggcaagg ccccagcagg tggcaatggc     2760

aacaagaaga agtcgggcaa gaaggagaag aagtaacatg gaggccaggc caagagccac     2820

agggcggcct ctccccaacc agcccagctt ctccttacct gcacccaggc ctcagagttt     2880

cagggctaac ccccagaata ctggtagggg ccaaggccat gctccccttg ggaaacagaa     2940

acaagtgccc agtcagcacc taccccttcc cccccagggg gttgaatatg caaaagcagt     3000

tccgctggga acccccatcc aatcaactgc tgtacccatg ggggtagtgg ggttactgta     3060

gacaccaaga accatttgcc acaccccgtt tagttacagc tgaactcctc catcttccaa     3120

atcaatcagg cccatccatc ccatgcctcc ctcctcccca ccccactcca acagttcctc     3180

tttcccgagt aaggtggttg gggtgttgaa gtaccaagta acctacaagc ctcctagttc     3240

tgaaaagttg gaagggcatc atgacctctt ggcctctcct ttgattctca atcttccccc     3300

aaagcatggt ttggtgccag ccccttcacc tccttccaga gcccaagatc aatgctcaag     3360

ttttggagga catgatcacc atccccatgg tactgatgct tgctggattt agggagggca     3420

ttttgctacc aagcctcttc ccaacgccct ggggaccagt cttctgtttt gtttttcatt     3480

gtttgacgtt tccactgcat gccttgactt cccccacctc ctcctcaaac aagagactcc     3540

actgcatgtt ccaagacagt atggggtggt aagataagga agggaagtgt gtggatgtgg     3600

atggtggggg catggacaaa gcttgacaca tcaagttatc aaggccttgg aggaggctct     3660

gtatgtcctc aggggactga caacatcctc cagattccag ccataaacca ataactaggc     3720

tggacccttc ccactacata atagggctca gcccaggcag ccagctttgg gctgagctaa     3780

caggaccaat ggattaaact ggcatttcag tccaaggaag ctcgaagcag gtttaggacc     3840

aggtcccctt gagaggtcag aggggcctct gtgggtgctg ggtactccag aggtgccact     3900

ggtggaaggg tcagcggagc cccagcagga agggtgggcc agccaggcca ttcttagtcc     3960

ctgggttggg gaggcaggga gctagggcag ggaccaaatg aacagaaagt ctcagcccag     4020

gatggggctt cttcaacagg gcccctgccc tcctgaagcc tcagtccttc accttgccag     4080

gtgccgtttc tcttccgtga aggccactgc ccaggtcccc agtgcgcccc ctagtggcca     4140

tagcctggtt aaagttcccc agtgcctcct tgtgcataga ccttcttctc ccaccccctt     4200

ctgcccctgg gtccccggcc atccagcggg gctgccagag aaccccagac ctgcccttac     4260

agtagtgtag cgccccctcc ctctttcggc tggtgtagaa tagccagtag tgtagtgcgg     4320

tgtgctttta cgtgatggcg ggtgggcagc gggcggcggg ctccgcgcag ccgtctgtcc     4380

ttgatctgcc cgcggcggcc cgtgttgtgt tttgtgctgt gtccacgcgc taaggcgacc     4440

ccctcccccg tactgacttc tcctataagc gcttctcttc gcatagtcac gtagctccca     4500

ccccaccctc ttcctgtgtc tcacgcaagt tttatactct aatatttata tggctttttt     4560

tcttcgacaa aaaaataata aaacgtttct tctgaaaagc tg                        4602


<210> 55
<211> 3114
<212> DNA
<213> Homo sapiens

<400> 55
aatcccagct cgcagccctt gctccgcgtg tactcacggg aggactcgca gacgttactg       60

ccctcttgcg tgccccggcc acccccgggc ggcttgtagc cggtgcgcgg ggtggctggg      120

gctacgtgca gagctgtcgc ggagccggaa cagcagcggt gaagcccctc ggctcggccg      180

agaccgccgt gcccactgct cgcctcggtt gccgccgctt tagccgcagc cgctgctgcc      240

gccgccgggg gagaggcagc ctattgtctt tctccgcggc gaaggtgagg agctgtctcg      300

gctcggcccg cgggggagcc ccgggagccg cacggagatg gaggaggaca tctggacagt      360

gagcaggagg cgcttcggcc catgccgaac atcccagggg acctggagag ccgggaggcc      420

atggtggcat ttttcaactc cgctggagcc aatgcccagg aggaacaaag ggtgtgctgc      480

cagcccctgg ctcacccagt ggcctcgtcc cagaaaaagc cagaggtagc ggccccagcc      540

ccagagagtg ggggtgagtc tgtgtttggg gagacccacc gggccctgca gggggccatg      600

gagaagctgc agcgacttta tggaaggaga aggtggacct gaaggagcgg gtagagaaac      660

tagagcttca attcatccac ctctcaggac agacagacac catagggaga aagtacatca      720

gccagggggc agtgtcagag acgcagcact gggagaggag gacatcgtca ggctggccca      780

ggaccaggag gagatgaagg tgaacctgca ggagctgcgg ggcaggtgtt gcagcttgtg      840

ggagaccaca aggaggggca tggcaaattc tgaccattgc ccagaaccct gctgatgagc      900

ccactctagg agccccaata gcccaggagc ttgggtgtgc tgacgagcag ggtgatcacc      960

actggattgc tgacagatag aggacgtggg accgtgacta tcacccctaa tctgcagtgg     1020

atttggctct cggcactccc aggctgggag ctggatacct gccctggcag catgactcag     1080

actgcatgac agtcacagac tcgcctctgc tcctgtggtc cagtggccgg acaccccctg     1140

ggatggctca aaggagtcag gacttggaag tggggacatc agggtagctg aaggaaatcc     1200

acacacccag agcatctcgg agttcagact ctcagacctg aagtaggcgc ccccgggact     1260

gggctaggag ttggacggaa tggaggatgg aggacagcga gaagaaagga agagaaatgc     1320

aaagtgtggg cagccgccaa gagtgaaaat agagggaagt gtcatgcaag tgctggacag     1380

aaggcggcag gtgggacgag ccccacagcc ccctcctcaa aaacgaccac ctccaggact     1440

cagtgatccc tggggggcag gctctgccag ccctcggcca cacgtggctc cggcacccat     1500

ggtcccagtg ccttggatgg agacggccag ttctggcggc cagatgtggt gctctggaat     1560

ccagtcccat ttccttcctg gccacgcctg tccagcggcc tcttcagccg cattcagccc     1620

ctacttacct ggggaccccg gctggggcac gagagcacca ggggggtagg gcccaaaggg     1680

atcaggggaa gcctctggcc tggagggtat ggggcacgct tccccaaggg cggacccggc     1740

aggaggaagc ccaggagctg ggtcctgccg cccaggagct gggccctgcc acccaggccg     1800

ggctagggac atggcagggc ctgggcatcc tgacgctgga cttgggcgac ctgggaggca     1860

cagggagggg agagatgggc gaccccgccc cagcgcagtg ccggccacac cccaaggcag     1920

ttgccagagc ttaagccccg cccccagcag cgagaacatc ccagctccac accccccccc     1980

cccccgcagc cagtgctcct tgtcaagctc cccccgtcac tccaggtggg agccaccccg     2040

gtgagggggt gtgccacttg cccccagggc actcctctgg gcatcccggg tgggggattt     2100

tggggccgtg gggggcagtc tttggtacct gtgttcgtca gggatgctct gacaaccagg     2160

tgtcgtccac gggcgggggc atgggcatgg tgacagtggt cctgttgatg tcaccgatga     2220

tgctgagcgc ctccttcagc gcgtggtgca tgtgcagcat ctcgtcgtgc tgctgtgcct     2280

gctctgccaa ctcctccatc agtgtgttct ggttcccaca tgagtacata ttggccagca     2340

gctccgagat gatgaactcc ggggtctgag agtgggcaaa cagggaagaa ggttgggacc     2400

tggtgcctgt gccgccctgg ctgccttgct gggcccttct gggactgtgc gctggacttg     2460

gagccccttg gagtatggct tttcacacgg gcttctatac cgcttcgact ggaagatcca     2520

cctccccact gccttttctc actcagatgg ggacaccgag gtccagagga aaagacacct     2580

gtcaaatgtc acagatctgg gaggggactt aagacttatc atgccaagag gacacctgtc     2640

tactcagttt ttttttggtg gggcgggggg cggtgatagg gtctcgctct gtcaccaggc     2700

tggagtacag tgatgactgc tcactgcagc ctccacctcc tgggctcaaa gtgatcctcc     2760

aacgtcagcc tctcgaggag ctaggactac aggcacatgc caccaccaag cccagctatt     2820

tttaaaattt ttgtgtggag acaaggtctc actatgtggc ccaggctggt ctcgaactcc     2880

tgggctcaag tgatcctcct gcctcggcct ccaggagtgg gagttggagt tgatgcctgg     2940

atacaggagc tctgtgggtg ggagtgagac aaaacacagg gtcctgagct ctggggacca     3000

agcaatgtcc tctggtgaaa aaaatcctgg acttgctggc agaagatttg cctcttactc     3060

gccatgtgct ctgaatacat ttacctgccc tctgggaaaa aaaaaaaaaa aaaa           3114


<210> 56
<211> 3357
<212> DNA
<213> Homo sapiens

<400> 56
aatcccagct cgcagccctt gctccgcgtg tactcacggg aggactcgca gacgttactg       60

ccctcttgcg tgccccggcc acccccgggc ggcttgtagc cggtgcgcgg ggtggctggg      120

gctacgtgca gagctgtcgc ggagccggaa cagcagcggt gaagcccctc ggctcggccg      180

agaccgccgt gcccactgct cgcctcggtt gccgccgctt tagccgcagc cgctgctgcc      240

gccgccgggg gagaggcagc ctattgtctt tctccgcggc gaaggtgagg agctgtctcg      300

gctcggcccg cgggggagcc ccgggagccg cacggtggca tttttcaact ccgctggagc      360

caatgcccag gaggaacaaa gggtgtgctg ccagcccctg gctcacccag tggcctcgtc      420

ccagaaaaag ccagaggtag cggccccagc cccagagagt gggggtgagt ctgtgtttgg      480

ggagacccac cgggccctgc agggggccat ggagaagctg cagcgacttt atggaaggag      540

aaggtggacc tgaaggagcg ggtagagaaa ctagagcttc aattcatcca cctctcagga      600

cagacagaca ccatagggag aaagtacatc agccaggggg cagtgtcaga gacgcagcac      660

tgggagagga ggacatcgtc aggctggccc aggaccagga ggagatgaag gtgaacctgc      720

aggagctgcg gggcaggtgt tgcagcttgt gggagaccac aaggaggggc atggcaaatt      780

ctgaccattg cccagaaccc tgctgatgag cccactctag gagccccaat agcccaggag      840

cttgggtgtg ctgacgagca gggtgatcac cactggattg ctgacagata gaggacgtgg      900

gaccgtgact atcaccccta atctgcagtg gatttggctc tcggcactcc caggctggga      960

gctggatacc tgccctggca gcatgactca gactgcatga cagagaacgt ggccagtgga     1020

gacggcacac tggaaatcag agtgaatgtt cttgaaagag ggtcacgggt caacaaggcc     1080

cagccaaagg atgcagtaga accattttcc ttagaaatct ttgggagtga agtaggcttc     1140

agccactccc atccctgccc tcgcggctac cactacccca ttagtttaga cagggtcggg     1200

cggggagggg tgtggagaag aaatgagctt gcctgtggcc cccaggctcc ctctgtccta     1260

gctcaggtct gggtgccatt ctttacactc gtgtgctcgc tcacgcacac atcacacacc     1320

ttgctggtca cacagtcaca gactcgcctc tgctcctgtg gtccagtggc cggacacccc     1380

ctgggatggc tcaaaggagt caggacttgg aagtggggac atcagggtag ctgaaggaaa     1440

tccacacacc cagagcatct cggagttcag actctcagac ctgaagtagg cgcccccggg     1500

actgggctag gagttggacg gaatggagga tggaggacag cgagaagaaa ggaagagaaa     1560

tgcaaagtgt gggcagccgc caagagtgaa aatagaggga agtgtcatgc aagtgctgga     1620

cagaaggcgg caggtgggac gagccccaca gccccctcct caaaaacgac cacctccagg     1680

actcagtgat ccctgggggg caggctctgc cagccctcgg ccacacgtgg ctccggcacc     1740

catggtccca gtgccttgga tggagacggc cagttctggc ggccagatgt ggtgctctgg     1800

aatccagtcc catttccttc ctggccacgc ctgtccagcg gcctcttcag ccgcattcag     1860

cccctactta cctggggacc ccggctgggg cacgagagca ccaggggggt agggcccaaa     1920

gggatcaggg gaagcctctg gcctggaggg tatggggcac gcttccccaa gggcggaccc     1980

ggcaggagga agcccaggag ctgggtcctg ccgcccagga gctgggccct gccacccagg     2040

ccgggctagg gacatggcag ggcctgggca tcctgacgct ggacttgggc gacctgggag     2100

gcacagggag gggagagatg ggcgaccccg ccccagcgca gtgccggcca caccccaagg     2160

cagttgccag agcttaagcc ccgcccccag cagcgagaac atcccagctc cacacccccc     2220

ccccccccgc agccagtgct ccttgtcaag ctccccccgt cactccaggt gggagccacc     2280

ccggtgaggg ggtgtgccac ttgcccccag ggcactcctc tgggcatccc gggtggggga     2340

ttttggggcc gtggggggca gtctttggta cctgtgttcg tcagggatgc tctgacaacc     2400

aggtgtcgtc cacgggcggg ggcatgggca tggtgacagt ggtcctgttg atgtcaccga     2460

tgatgctgag cgcctccttc agcgcgtggt gcatgtgcag catctcgtcg tgctgctgtg     2520

cctgctctgc caactcctcc atcagtgtgt tctggttccc acatgagtac atattggcca     2580

gcagctccga gatgatgaac tccggggtct gagagtgggc aaacagggaa gaaggttggg     2640

acctggtgcc tgtgccgccc tggctgcctt gctgggccct tctgggactg tgcgctggac     2700

ttggagcccc ttggagtatg gcttttcaca cgggcttcta taccgcttcg actggaagat     2760

ccacctcccc actgcctttt ctcactcaga tggggacacc gaggtccaga ggaaaagaca     2820

cctgtcaaat gtcacagatc tgggagggga cttaagactt atcatgccaa gaggacacct     2880

gtctactcag tttttttttg gtggggcggg gggcggtgat agggtctcgc tctgtcacca     2940

ggctggagta cagtgatgac tgctcactgc agcctccacc tcctgggctc aaagtgatcc     3000

tccaacgtca gcctctcgag gagctaggac tacaggcaca tgccaccacc aagcccagct     3060

atttttaaaa tttttgtgtg gagacaaggt ctcactatgt ggcccaggct ggtctcgaac     3120

tcctgggctc aagtgatcct cctgcctcgg cctccaggag tgggagttgg agttgatgcc     3180

tggatacagg agctctgtgg gtgggagtga gacaaaacac agggtcctga gctctgggga     3240

ccaagcaatg tcctctggtg aaaaaaatcc tggacttgct ggcagaagat ttgcctctta     3300

ctcgccatgt gctctgaata catttacctg ccctctggga aaaaaaaaaa aaaaaaa        3357


<210> 57
<211> 2975
<212> DNA
<213> Homo sapiens

<400> 57
aatcccagct cgcagccctt gctccgcgtg tactcacggg aggactcgca gacgttactg       60

ccctcttgcg tgccccggcc acccccgggc ggcttgtagc cggtgcgcgg ggtggctggg      120

gctacgtgca gagctgtcgc ggagccggaa cagcagcggt gaagcccctc ggctcggccg      180

agaccgccgt gcccactgct cgcctcggtt gccgccgctt tagccgcagc cgctgctgcc      240

gccgccgggg gagaggcagc ctattgtctt tctccgcggc gaaggtggca tttttcaact      300

ccgctggagc caatgcccag gaggaacaaa gggtgtgctg ccagcccctg gctcacccag      360

tggcctcgtc ccagaaaaag ccagaggtag cggccccagc cccagagagt gggggtgagt      420

ctgtgtttgg ggagacccac cgggccctgc agggggccat ggagaagctg cagcgacttt      480

atggaaggag aaggtggacc tgaaggagcg ggtagagaaa ctagagcttc aattcatcca      540

cctctcagga cagacagaca ccatagggag aaagtacatc agccaggggg cagtgtcaga      600

gacgcagcac tgggagagga ggacatcgtc aggctggccc aggaccagga ggagatgaag      660

gtgaacctgc aggagctgcg gggcaggtgt tgcagcttgt gggagaccac aaggaggggc      720

atggcaaatt ctgaccattg cccagaaccc tgctgatgag cccactctag gagccccaat      780

agcccaggag cttgggtgtg ctgacgagca gggtgatcac cactggattg ctgacagata      840

gaggacgtgg gaccgtgact atcaccccta atctgcagtg gatttggctc tcggcactcc      900

caggctggga gctggatacc tgccctggca gcatgactca gactgcatga cagtcacaga      960

ctcgcctctg ctcctgtggt ccagtggccg gacaccccct gggatggctc aaaggagtca     1020

ggacttggaa gtggggacat cagggtagct gaaggaaatc cacacaccca gagcatctcg     1080

gagttcagac tctcagacct gaagtaggcg cccccgggac tgggctagga gttggacgga     1140

atggaggatg gaggacagcg agaagaaagg aagagaaatg caaagtgtgg gcagccgcca     1200

agagtgaaaa tagagggaag tgtcatgcaa gtgctggaca gaaggcggca ggtgggacga     1260

gccccacagc cccctcctca aaaacgacca cctccaggac tcagtgatcc ctggggggca     1320

ggctctgcca gccctcggcc acacgtggct ccggcaccca tggtcccagt gccttggatg     1380

gagacggcca gttctggcgg ccagatgtgg tgctctggaa tccagtccca tttccttcct     1440

ggccacgcct gtccagcggc ctcttcagcc gcattcagcc cctacttacc tggggacccc     1500

ggctggggca cgagagcacc aggggggtag ggcccaaagg gatcagggga agcctctggc     1560

ctggagggta tggggcacgc ttccccaagg gcggacccgg caggaggaag cccaggagct     1620

gggtcctgcc gcccaggagc tgggccctgc cacccaggcc gggctaggga catggcaggg     1680

cctgggcatc ctgacgctgg acttgggcga cctgggaggc acagggaggg gagagatggg     1740

cgaccccgcc ccagcgcagt gccggccaca ccccaaggca gttgccagag cttaagcccc     1800

gcccccagca gcgagaacat cccagctcca cacccccccc ccccccgcag ccagtgctcc     1860

ttgtcaagct ccccccgtca ctccaggtgg gagccacccc ggtgaggggg tgtgccactt     1920

gcccccaggg cactcctctg ggcatcccgg gtgggggatt ttggggccgt ggggggcagt     1980

ctttggtacc tgtgttcgtc agggatgctc tgacaaccag gtgtcgtcca cgggcggggg     2040

catgggcatg gtgacagtgg tcctgttgat gtcaccgatg atgctgagcg cctccttcag     2100

cgcgtggtgc atgtgcagca tctcgtcgtg ctgctgtgcc tgctctgcca actcctccat     2160

cagtgtgttc tggttcccac atgagtacat attggccagc agctccgaga tgatgaactc     2220

cggggtctga gagtgggcaa acagggaaga aggttgggac ctggtgcctg tgccgccctg     2280

gctgccttgc tgggcccttc tgggactgtg cgctggactt ggagcccctt ggagtatggc     2340

ttttcacacg ggcttctata ccgcttcgac tggaagatcc acctccccac tgccttttct     2400

cactcagatg gggacaccga ggtccagagg aaaagacacc tgtcaaatgt cacagatctg     2460

ggaggggact taagacttat catgccaaga ggacacctgt ctactcagtt tttttttggt     2520

ggggcggggg gcggtgatag ggtctcgctc tgtcaccagg ctggagtaca gtgatgactg     2580

ctcactgcag cctccacctc ctgggctcaa agtgatcctc caacgtcagc ctctcgagga     2640

gctaggacta caggcacatg ccaccaccaa gcccagctat ttttaaaatt tttgtgtgga     2700

gacaaggtct cactatgtgg cccaggctgg tctcgaactc ctgggctcaa gtgatcctcc     2760

tgcctcggcc tccaggagtg ggagttggag ttgatgcctg gatacaggag ctctgtgggt     2820

gggagtgaga caaaacacag ggtcctgagc tctggggacc aagcaatgtc ctctggtgaa     2880

aaaaatcctg gacttgctgg cagaagattt gcctcttact cgccatgtgc tctgaataca     2940

tttacctgcc ctctgggaaa aaaaaaaaaa aaaaa                                2975


